Cognitive Neuroscience Society, 2015

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<ul><li><p>RESEARCH POSTER PRESENTATION DESIGN 2012 </p><p>www.PosterPresentations.com </p><p>(THIS SIDEBAR DOES NOT PRINT) DESIGN GUIDE </p><p> This PowerPoint 2007 template produces a 100cmx140cm presentation poster. You can use it to create your research poster and save valuable time placing titles, subtitles, text, and graphics. We provide a series of online tutorials that will guide you through the poster design process and answer your poster production questions. To view our template tutorials, go online to PosterPresentations.com and click on HELP DESK. When you are ready to print your poster, go online to PosterPresentations.com Need assistance? Call us at 1.510.649.3001 </p><p>QUICK START </p><p>Zoom in and out As you work on your poster zoom in and out to the level </p><p>that is more comfortable to you. Go to VIEW &gt; ZOOM. </p><p>Title, Authors, and Affiliations Start designing your poster by adding the title, the names of the authors, and the affiliated institutions. You can type or paste text into the provided boxes. The template will automatically adjust the size of your text to fit the title box. You can manually override this feature and change the size of your text. TIP: The font size of your title should be bigger than your name(s) </p><p>and institution name(s). </p><p>Adding Logos / Seals Most often, logos are added on each side of the title. You can insert a logo by dragging and dropping it from your desktop, copy and paste or by going to INSERT &gt; PICTURES. Logos taken from web sites are likely to be low quality when printed. Zoom it at 100% to see what the logo will look like on the final poster and make any necessary adjustments. TIP: See if your schools logo is available on our free poster templates page. </p><p>Photographs / Graphics You can add images by dragging and dropping from your desktop, copy and paste, or by going to INSERT &gt; PICTURES. Resize images proportionally by holding down the SHIFT key and dragging one of the corner handles. For a professional-looking poster, do not distort your images by enlarging them disproportionally. </p><p>Image Quality Check Zoom in and look at your images at 100% magnification. If they look good they will print well. ORIGINAL DISTORTED </p><p>Corner handles </p><p>Good</p><p> prin</p><p>/ng qu</p><p>ality</p><p>Bad prin/n</p><p>g qu</p><p>ality</p><p>QUICK START (cont.) </p><p>How to change the template color theme You can easily change the color theme of your poster by going to the DESIGN menu, click on COLORS, and choose the color theme of your choice. You can also create your own color theme. You can also manually change the color of your background by going to VIEW &gt; SLIDE MASTER. After you finish working on the master be sure to go to VIEW &gt; NORMAL to continue working on your poster. </p><p>How to add Text The template comes with a number of pre-</p><p>formatted placeholders for headers and text blocks. You can add more blocks by copying and pasting the existing ones or by adding a text box from the HOME menu. </p><p> Text size </p><p>Adjust the size of your text based on how much content you have to present. The default template text offers a good starting point. Follow the conference requirements. </p><p> How to add Tables </p><p>To add a table from scratch go to the INSERT menu and click on TABLE. A drop-down box will help you select rows and columns. You can also copy and a paste a table from Word or another PowerPoint document. A pasted table may need to be re-formatted by RIGHT-CLICK &gt; FORMAT SHAPE, TEXT BOX, Margins. </p><p>Graphs / Charts You can simply copy and paste charts and graphs from Excel or Word. Some reformatting may be required depending on how the original document has been created. </p><p>How to change the column configuration RIGHT-CLICK on the poster background and select LAYOUT to see the column options available for this template. The poster columns can also be customized on the Master. VIEW &gt; MASTER. </p><p> How to remove the info bars </p><p>If you are working in PowerPoint for Windows and have finished your poster, save as PDF and the bars will not be included. You can also delete them by going to VIEW &gt; MASTER. On the Mac adjust the Page-Setup to match the Page-Setup in PowerPoint before you create a PDF. You can also delete them from the Slide Master. </p><p>Save your work Save your template as a PowerPoint document. For printing, save as PowerPoint of Print-quality PDF. </p><p>Print your poster When you are ready to have your poster printed go online to PosterPresentations.com and click on the Order Your Poster button. Choose the poster type the best suits your needs and submit your order. If you submit a PowerPoint document you will be receiving a PDF proof for your approval prior to printing. If your order is placed and paid for before noon, Pacific, Monday through Friday, your order will ship out that same day. Next day, Second day, Third day, and Free Ground services are offered. Go to PosterPresentations.com for more information. </p><p>Student discounts are available on our Facebook page. Go to PosterPresentations.com and click on the FB icon. </p><p> 2013 PosterPresenta/ons.com 2117 Fourth Street , Unit C Berkeley CA 94710 posterpresenter@gmail.com </p><p>Subjects: </p><p> n=10 patients with moderate, chronic agrammatic aphasia pooled from Thompson et al., 2010 (n=5) and an ongoing study at the Center for the Neurobiology of Language Recovery (CNLR) (n=5). </p><p> All patients were trained to produce and comprehend non-canonical sentences (object relative in 2010, passive in CNLR) using Treatment of Underlying Forms (Thompson, 2008). </p><p>Data Analysis:</p><p> % ROI Lesioned: After T1 pre-processing in SPM8, MRIcron was used to manually draw lesions and calculate percent tissue lesioned in each ROI (Fig. 3).</p><p> Perfusion: Virtual brain transplant technique (Fig. 4) (Solodkin et al., 2010) performed on T1 scans prior to normalization and segmentation in VBM. Custom software used to model CBF using fMRI arterial spin labeling (ASL) images before coregistering to transplanted image. Regional CBF was normalized to mean CBF across the right hemisphere. </p><p> Cognitive effects of stroke may include agrammatic aphasia, a syntactic processing impairment. Non-canonical word order (2, 3) is more difficult to process than canonical word order (1):</p><p>(1) The girl kissed the boy. </p><p> ACTIVE</p><p>(2) Pete saw the boy who the girl kissed. OBJECT RELATIVE</p><p>(3) The boy was kissed by the girl. PASSIVE</p><p> Patients can improve with treatment, even in the chronic stage of aphasia (Thompson et al., 2010), but the underlying neurobiology of recovery is unclear.</p><p> Neurobiological effects of stroke include necrosis (lesion) and hypoperfusion, especially in ipsilesional and perilesional tissue (Fig. 1). </p><p> Lesion volume has limited clinical utility for predicting recovery (Caplan et al., 2007). Lesion-deficit relations vary greatly between individuals (Price &amp; Friston, 2002), and recovery during acute stroke can be predicted without lesion volume (El Hachioui et al., 2012). There are likely other important factors (Caplan et al., 2007).</p><p> More-normal hemodynamics is correlated with impairment severity and recovery (Fridriksson et al., 2010; Hillis et al., 2000, 2001; Payabvash et al., 2010; Silvestrini et al., 1998). However, most research in this area has been done on acute stroke, when changes in cerebral physiology occur that may confound these correlations.</p><p>Background</p><p>?</p><p>The Present Study</p><p>Methods</p><p>Conclusions &amp; Discussion</p><p>Contact: fitzmorris@u.northwestern.edu </p><p>Fig. 4: Brain transplant technique</p><p>A: ASL fMRI: Ipsilesional hypoperfusion (Thompson et al., 2010). B: 3D image reconstruc/on of rCBF in an adult with chronic aphasia (leS) and a healthy adult (right). </p><p>Fig. 3: ROIs</p><p>Results Left hemisphere was hypoperfused relative to the right hemisphere.</p><p> Significant factors of Improvement:</p><p> % Compensatory ROI lesioned (r = -.7, p &lt; .05)</p><p> Perilesional perfusion (B = -3, p &lt; .001)</p><p> Study (B = -.2, p &lt; .01)</p><p> Pre-treatment comprehension (B = -.9, p &lt; .001)</p><p> Total lesion volume was not a predictor of improvement, thus providing further support for lesion-deficit variability (Caplan et al., 2007; Hillis et al., 2000).</p><p> Greater recovery of sentence comprehension predicted by higher pre-treatment comprehension and lower perfusion in perilesional tissue.</p><p> Could perilesional tissue hinder, rather than support recovery in chronic stroke?</p><p> Future studies are needed to investigate links, if any, between pre-treatment perfusion and changes in neural activity associated with language recovery.</p><p> Hillis AE, Barker PB, Beauchamp NJ, Gordon B, &amp; Wityk RJ, (2000). MR perfusion imaging reveals regions of hypoperfusion associated with aphasia and neglect. Neurology, 55, 782-788.</p><p> Hillis AE, Barker PB, Beauchamp NJ, Winters BD, Mirski M, &amp; Wityk RJ, (2001). Restoring blood pressure reperfused Wernickes area and improved language. Neurology, 56, 670-672.</p><p> El Hachioui, H., Lingsma, H. F., van de Sandt-Koenderman, M. W. M. E., Dippel, D. W. J., Koudstaal, P. J., &amp; Visch-Brink, E. G. (2013). Long-term prognosis of aphasia after stroke. Journal of </p><p>Neurology, Neurosurgery, and Psychiatry, 84(3), 310315. http://doi.org/10.1136/jnnp-2012-302596</p><p> Fridriksson J, Kjartansson O, Morgan PS, Hjaltason H, Magnusdottir S, Bonilha L, &amp; Rorden C, (2010). Impaired speech repetition and left parietal lobe damage. Journal of Neuroscience, </p><p>30(33): 11057-11061.</p><p> Fridriksson J, Richardson JD, Fillmore P, &amp; Cai B, (2012). Left hemisphere plasticity and aphasia recovery. NeuroImage, 60, 854-863.</p><p> Pavbayash S, Kamalian S, Fung S, Wang Y, Passanese J, Kamalian S, Souza LCS, Kemmling A, Harris GJ, Halpern EF, Gonzalez RG, Furie KL, Lev MH (2010). Predicting language improvement in </p><p>acute stroke patients presenting with aphasia: A multivariate logistic model using location-weighted atlas-based analysis of admission CT perfusion scans. American Journal of Neuroradiology, 31, 1661-1668. </p><p> Price, C. J., &amp; Friston, K. J. (2002). Degeneracy and cognitive anatomy. Trends in Cognitive Sciences, 6(10), 416421.</p><p> Solodkin, A., Hasson, U., Siugzdaite, R., Schiel, M., Chen, E. E., Rolf, K., &amp; Small, S. L. (2010). Virtual Brain Transplantation (VBT): A method for accurate image registration and parcellation in </p><p>large cortical stroke. Archives Italiennes de Biologie, 148(3), 219241. http://doi.org/10.4449/aib.v148i3.1221</p><p> Thompson CK, den Ouden DB, Bonakdarpour B, Garibaldi K, Parrish TB (2010). Neural plasticity and treatment-induced recovery of sentence processing in agrammatism. Neuropsychologia </p><p>48: 3211-3227.</p><p> Thompson (2008). Treatment of syntactic and morphological deficits in agrammatic aphasia: Treatment of Underlying Forms. In R. Chapey (Ed.), Language intervention strategies in aphasia and </p><p>related neurogenic communication disorders. Baltimore: Williams &amp; Wilkins.</p><p>Aims: Examine longitudinal relations between pre-treatment perfusion and lesion volume in regions of the brain involved in sentence processing, and treatment-related improvement in non-canonical sentence comprehension.</p><p> Research Questions:</p><p>1. Can regional perfusion predict subsequent language recovery in chronic agrammatic aphasia?</p><p>2. Is the relation between perfusion or lesion volume and improvement in sentence processing specific to language regions?</p><p>Selected References</p><p>Fig. 1 A B </p><p>Statistics:</p><p> Spearman correlations between Improvement in comprehension of trained sentence type, and regional perfusion or lesion volume</p><p> Stepwise linear regression between improvement and factors: perilesional perfusion, study, total lesion volume, pre-treatment comprehension.</p><p>Research supported by the National Institutes of Health, P50DC012283 and R01-DC007213, and The Graduate School at </p><p>Northwestern University</p><p>1Aphasia and Neurolinguistics Research Laboratory, Department of Communication Sciences and Disorders, Northwestern University, Evanston, IL 2Center for Translational Imaging, Department of Radiology, Northwestern University, Chicago, IL</p><p>3Cognitive Neurology and Alzheimers Disease Center and Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, IL.</p><p>Perfusion and Recovery of Syntactic Comprehension </p><p>in Chronic Agrammatic Aphasia</p><p>Ellen Fitzmorris1, Yufen Chen2, Todd Parrish2, Cynthia K. Thompson1,3</p></li></ul>

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