clostridium botulinum type b toxoid - animal...
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L1460-0314• ©2014,NeogenCorporation.NeogenandBotVaxareregisteredtrademarksofNeogenCorporation,Lansing,MI.Allothertrademarksarepropertiesoftheirrespectiveowners.
BotVax® BClostridium botulinum Type B Toxoid
Neogen Corporation, 944 Nandino Blvd., Lexington, KY 40511 USA • 800/525-2022 • Fax: 877/228-7229 • www.neogen.com • e-mail: [email protected]
Indications BotVax B is a USDA approved monovalent vaccine (toxoid) for the prevention of equine botulism Type B due to Clostridium botulinum in healthy horses.
This product does not confer protection against other C. botulinum toxin types.
IngredientsPurified botulinum type B toxoid, aluminum phosphate absorbed
Thimerosal (as preservative) 0.01%
Formaldehyde (as inactivating solution) ≤1.85 g/L
Presentation200180 10 mL vial (5 doses per vial) 12 vials/ case
200181 2 mL vial (1 dose per vial) 12 vials/ pack
Directions for Use• Shake well before use.
• Inject 2 mL intramuscularly, using aseptic technique, at monthly intervals for a total of 3 doses.
• Booster annually with a single 2 mL intramuscular dose.
Research has demonstrated that pregnant mares immunized during the third trimester of gestation, with the third dose (booster) given 2-4 weeks before parturition, respond with antibody. This antibody is concentrated in colostrum and results in significant passively acquired antibody in normal suckling foals.
CautionDo not vaccinate food-producing animals within 21 days of slaughter.
Local reactions at the injection site, such as heat and minor swelling, may occur.
Anaphylactic reactions may occur.
WarningsFor veterinary use only.
Not for human use.
Keep out of reach of children.
For animal use only.
StorageStore unopened vials at 2° - 7°C (35° - 45°F).
DO NOT FREEZE.
Use the entire contents of the container when first opened. Do not store opened vials.
Our goal is to provide horse owners, veterinarians, horse lovers, industry officials, and the public with all the information
available on this deadly disease so the best choices can be made for the animals we care for.
Be sure to check out our botulism blog. www.equinebotulism.com
Notes:1. Horses are also susceptible to Clostridium botulinum types A, C, and potentially D.2. BotVax B does not confer protection against other Clostridium botulinum toxin types.3. U.S. Veterinary License no. 3024. http://www.aaep.org/botulism.htm
800/525-2022 • 859/254-1221944 Nandino Blvd. • Lexington, KY [email protected]
Prevention is the best defense• Botulinumtoxinsareamongthemostdeadlytoxinsintheworld• Horsesareextremelysensitivecomparedtootherspecies• Timeisacriticalfactorduetotherapidandsevereprogressionofthis
neuroparalyticdisease• Vaccination is far less expensive than treatment, which can exceed
$10,000withnoguaranteeforsurvival
Clostridium botulinum type B• Accountsformorethan85%ofequinebotulismcases1
• Strikesbothadulthorsesandfoalsrapidlyandismostoftenfatal• Severalstudiesplacethemortalityratearound70%
• Producessporesinsoilsworldwidethatremainviableformanyyears• CloselyrelatedtoClostridium tetani,butismuchmoredeadly
Risk factors• Anybaledhay(round,square,bigorsmall),haylageorsilageproducts• Horsesandfoalsthatreside,inortravelto,endemicareas• Horsesthattravelforshows,races,andotherequineevents• Horsesthatmaysustainawound,includinginjectionsiteabscesses,
umbilicalinfections,puncturewounds,andcastrationsites
BotVax® B provides simple and safe protection against type B2 equine botulism• TheonlyUSDA-approved3vaccineforequinebotulism• Soldexclusivelytolicensedveterinarianssince1987• Safetoadministertohealthyadulthorses,pregnantmares,andfoals
twoweeksofageandolder• Three-doseinitialserieswithsingleannualboosterthereafter• ProtectsagainstallmodesofTypeBequinebotulism
• Foragepoisoning• Shakerfoalsyndrome(Toxicoinfectiousbotulism)• Woundbotulism
• BotulismisincludedinTheAmericanAssociationofEquinePractitionersVaccinationGuidelines4