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CHMI 2227EBiochemistry I

Introduction

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What is Biochemistry?

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What is Biochemistry?

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What do biochemists do?

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Example 1Myostatin deficiency and muscular development

Normal mouse Mighty mouse

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Example 2Leptin deficiency and obesity

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Boy with an inherited deficiency in the gene encoding leptin

- Top: at age 3

- Bottom: same boy, at age 8, after years of treatment with leptin

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Example 3:Hutchinson-Gilford Progeria Syndrome

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Ultrastructure of life - the AIDS virus

LipidsNucleic acidsProteinsSugars

http://en.wikipedia.org/wiki/Image:800px-HIV_Viron.png

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Ultrastructure of life - A bacteria

LipidsNucleic acidsProteinsSugars

http://en.wikipedia.org/wiki/Image:Prokaryote_cell_diagram.svg

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Ultrastructure of life - A mammalian cell

1- Nucleolus Synthesis of ribosomes

2- Nucleus Contains DNA Site of DNA and RNA synthesis

3- Ribosome Contains RNA and proteins Site of protein sythesis

4 –secretory vesicle Transport

5- rough endoplasmic reticulum Cellular highway

6- Golgi appatarus Cellular highway Sugarland!

http://en.wikipedia.org/wiki/Image:Biological_cell.svg

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Ultrastructure of life - A mammalian cell

7- Cytoskeleton Scaffold

8- Smooth endoplasmic reticulum Cellular highway

9- Mitochondria Powerhouse

10 –Vacuole Storage

11- Cytoplasm Cellular Jello

12 – Lysosome Digestive organ of the cell

13 – Centriole Makes flagella/cilia Required during cell division

http://en.wikipedia.org/wiki/Image:Biological_cell.svg

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http://probes.invitrogen.com/servlets/photo?fileid=g001835&company=probes

Red: mitochondria

Blue: Nucleus

Green: cytoskeleton