1999 alkaloids

alkaloidsU 0600

39 - 187The Synthesis of (-)-cis- and (-)-trans-Crobarbatic Acid. — Thesynthesis of the title acids (VII), hydrolysis products of a group of pyrrolizidinealkaloids, is achieved in five steps starting from commercially available 3-methyl-2-furoic acid, involving the highly diastereoselective Birch reductivealkylation of the chiral furoic acid amide (I) as key step. — (DONOHOE,TIMOTHY J.; STEVENSON, CLARE A.; HELLIWELL, MADELEINE;IRSHAD, RANAH; LADDUWAHETTY, TAMARA; Tetrahedron: Asymmetry10 (1999) 7, 1315-1322; Dep. Chem., Victoria Univ., Manchester M13 9PL, UK;EN)

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