1997 nucleic acids

nucleic acidsU 0700

20 - 200The Synthesis and Binding Properties of Oligonucleotide AnaloguesContaining Diastereomerically Pure Conformationally RestrictedAcetal Linkages. — The synthesis of dimers such as (XI) bearing thetitle linkage is achieved directly from allyl nucleoside derivative (I). The twodiastereomers are separated and incorporated in a single position within anoligonucleotide sequence. The binding properties are evaluated by thermaldenaturation analysis (Tm). The Tm of the ON, containing dimer (XI), is lowercompared to the reference compound and no binding is observed for the ON,containing the dimer, obtained from (IX). — (WANG, J.; MATTEUCCI, M.D.; Bioorg. Med. Chem. Lett. 7 (1997) 2, 229-232; Gilead Sci., Inc., FosterCity, CA 94404, USA; EN)

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