cheminform abstract: synthesis of substituted oxazolo[4,5-b]pyridine derivatives

1

2001 fused pyridine derivatives fused pyridine derivatives R 0450 48 - 124 Synthesis of Substituted Oxazolo[4,5-b]pyridine Derivatives. — 2-Substituted oxazolopyridines of type (V) and (XIII) are prepared by acid- mediated cyclization of the hydroxyaminopyridine (III) with carboxylic acids. Heck reaction with acrylic ester (VI) is used to introduce a carboxylic acid function and a basic moiety required for GPIIb/GPIIIa antagonism is obtained by guanylation. — (GRUMEL, VALERIE; MEROUR, JEAN-YVES; GUIL- LAUMET, GERALD; Heterocycles 55 (2001) 7, 1329-1345; Inst. Chim. Org. Anal., CNRS, Fac. Sci., Univ. Orleans, F-45067 Orleans, Fr.; EN) 1

Upload: valerie-grumel

Post on 06-Jun-2016

218 views

Category:

Documents

3 download

Report

Download

Embed Size (px):

TRANSCRIPT

Page 1: ChemInform Abstract: Synthesis of Substituted Oxazolo[4,5-b]pyridine Derivatives

2001 fused pyridine derivatives

fused pyridine derivativesR 0450

48 - 124Synthesis of Substituted Oxazolo[4,5-b]pyridine Derivatives. —2-Substituted oxazolopyridines of type (V) and (XIII) are prepared by acid-mediated cyclization of the hydroxyaminopyridine (III) with carboxylic acids.Heck reaction with acrylic ester (VI) is used to introduce a carboxylic acidfunction and a basic moiety required for GPIIb/GPIIIa antagonism is obtainedby guanylation. — (GRUMEL, VALERIE; MEROUR, JEAN-YVES; GUIL-LAUMET, GERALD; Heterocycles 55 (2001) 7, 1329-1345; Inst. Chim. Org.Anal., CNRS, Fac. Sci., Univ. Orleans, F-45067 Orleans, Fr.; EN)

1

PYRIDINE AND PYRIDINE DERIVATIVES - chemistry…chemistry.mdma.ch/.../000537223-Pyridine_and_Pyridine_Derivates.pdf · PYRIDINE AND PYRIDINE DERIVATIVES ... As is the case with most

2D lanthanide-based pyridine-substituted triazole benzoate

Mechanistic Investigations and Substrate Scope Evaluation ... · PDF filefrom commercially available 2-chloro-3-substituted pyridine ... This catalytic method was found ... . bConversion

ChemInform RxnFinder

Synthesis of Novel 6-Substituted and 5-Substituted Pyrrolo

Pyridine Ligands

Using SeO2 as a Selenium Source to Make RSe- · Using SeO2 as a Selenium Source to Make RSe-Substituted Aniline and Imidazo[1,2-a]pyridine Derivatives Yaokun Ren,a Baojun Xu,a Zijian

PYRIDINE 1. Exposure Data

Molecular Orbitals-Boron Oxygen Pyridine v3

Pyridines, Pyridine and Pyridine Rings: Disambiguating Chemical

Pyridine N-Oxides

Global Pyridine Market 2016-2020

Infrared Spectral Study of Metal-Pyridine, -Substituted Pyridine,

Soluble polyimides based on a novel pyridine-containing diamine mp … · (2011) 66:1191–1206 DOI 10.1007/s00289-010-0343-5. Keywords Pyridine-containing diamine Pyridine-containing

Pyridine - Guan Shin Yeh · Pyridine is moderately to severely irritating to skin, eyes and mucous membranes. Vapors may be irritating to the respiratory tract. Pyridine is readily

pertinent assignmentsFIG. 2.-Log ARMvs. log mole fraction pyridine. Amino acids are chromatographed in a series of pyridine, 2,6-dil\e pyridine, water mixtures. Themole fraction of

substituted pyridines. trinitrobenzene, 9 ... · Table S1 Experimental masses of the substituted pyridine component mass (0.046 mmol) 1 2NH2py 4 mg 2 3NH2py 4 mg 3 4NH2py 4 mg 4 6Br-3NH2py

BIOASSAY OF 2-(CHLOROMETHYL)PYRIDINE FOR POSSIBLE ... · pyridine hydrochloride was conducted using Fischer 344 rats and B6C3F1 mice. 2-(Chloromethyl)pyridine hydrochloride was administered

PYRIDINE AND PYRIDINE DERIVATIVES - chemistry.mdma · 2020. 8. 17. · pyridine are aromatic compounds having resonance energies of similar magnitude, and both are miscible with most

The rotational spectra of helium- pyridine and hydrogen molecule- pyridine clusters Chakree Tanjaroon and Wolfgang Jger

ةها م ا آ ةد ا ن ة ˘و ميلاد محارب.pdf · 4- Activated Nitriles In Heterocyclic Synthesis: A Novel Synthesis of Polyfunctionally Substituted Pyridine Derivatives

Synthesis of Pyridine-Dicarboxamide-Cyclohexanone

Synthesis of 2-substituted pyridines from pyridine N-oxides

The role of substituted pyridine Schiff bases as ancillary

PYRIDINE NUCLEOTIDE TRANSHYDROGENASE

UNEXPECTED CYCLIZATION OF DIPYRIDYL-GLYCOLURIL IN THE ... · calix[4]arene derivatives. In an attempted synthesis of peripherally pyridine substituted cucurbituril, an unexpected

Pyridine Boronic Acids

Fjmu...pyrrole, structure and function of imidazole. 3. Structure and properties of pyridine and pyrimidine: structure and properties of pyridine and pyrimidine (solubility of pyridine,

SIX MEMBERED AROMATIC HETEROCYCLES Pyridine is aromatic … · 50 N.. Pyridine Pyridine is aromatic as there are six delocalized electrons in the ring. Six-membered heterocycles are

Efficient Iridium Water Oxidation Catalysts based on ... · substituted pyridine-carboxylate (pic) ligands, based on the best-performing Ir WOC reported in literature. The tunability

(Methanolato)(pyridine)[N2,N2'-(pyridine-2,6 ... · A pyridine solution (10 mL) of N,N'-diacetyl-2,6-picoloylhydrazide (0.2 mmol,0.0559 g) was mixed with a methanol solu-tion (10

PYRIDINE AND PYRIDINE DERIVATIVES - Sciencemadness

NIH Public Access Christopher D. Gilmore, and Brian M ...authors.library.caltech.edu/39741/7/nihms468985.pdf · The 2-substituted pyridine motif ... consequence of the temperatures

ChemInform Sheet A4 · 2013. 9. 13. · The ChemInform Reaction Library (CIRX) helps to deal with the enormous number of published reactions as it does not cover all information available

Preparation of Polyfunctionally Substituted Pyridine-2(1H)-Thione Derivatives … · 2014-12-31 · forded the corresponding 5acetyl--3-amino-6-methylthieno[2,3-b]pyridine derivatives