1999 nucleic acids

nucleic acidsU 0700

38 - 207Synthesis of DNA-(3’)-PNA Chimeras with Conformationally Re-stricted Linkers Based on 4-Hydroxyproline. — The synthesis of fourdiastereomeric linker molecules based on 4-hydroxyproline [cf. (XI), (XIV)]and their incorporation in DNA-(3’)-PNA chimeras are described. Enzymaticand thermal stability of the new hybrids are established. — (VERHEIJEN,JEROEN C.; VAN ROON, ANNE-MARIE M.; VAN DER LAAN, ALEXAN-DER C.; VAN DER MAREL, GIJSBERT A.; VAN BOOM, JACQUES H.;Nucleosides Nucleotides 18 (1999) 3, 493-508; Leiden Inst. Chem., Leiden Univ.,NL-2300 RA Leiden, Neth.; EN)

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