1998 organo-phosphorus compounds, acyclic C derivatives

organo-phosphorus compounds, acyclic C derivativesS 0082

27 - 220Studies on Organophosphorus Compounds. Part 101. A FacileSynthetic Route to Trifluoromethylated Aminophosphonic Acids andPhosphonopeptides. — Key step in the synthesis of trifluoromethylatedaminophosphonic acid (V) is the Arbuzov rearrangement of imidoyl chlorides(I) with triethylphosphite. Different N-protecting groups are investigated.Coupling reaction of phosphonic acid (V) with a second amino acid moiety givesthe protected phosphonopeptides (VII) in relatively low yields. — (YUAN,C.; ZHANG, Y.; LUO, W.; YAO, Z.; Heteroat. Chem. 9 (1998) 2, 139-146;Shanghai Inst. Org. Chem., Acad. Sin., Shanghai 200032, Peop. Rep. China;EN)

1