1997 antibiotics

antibioticsU 1200

25 - 229Novel C-2 Substituted Carbapenem Derivatives. Part 1. Synthesisand Biological Activity of Non-Aromatic Heterocyclic Derivatives.— A series of new carbapenems, e.g. (III), (XI), and (XIV), is investigatedfor biological activity. It is shown that (S)- stereochemistry at the C-2 sidechain and the introduction of a double bond in the heterocycle affords betterstability of these compounds to human dehydropeptidase-1 (DHP-1) besidesof good activity. — (BURTON, G.; CLEAR, N. J. C.; EGLINGTON, A. J.;GUEST, A. W.; HUNT, E.; NAYLOR, A.; PEARSON, M. J.; TAKLE, A. K.;J. Antibiot. 49 (1996) 12, 1258-1265; SmithKline Beecham Pharm., Betchworth,Surrey RH3 7AJ, UK; EN)

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