1998 aminocarboxylic acids

aminocarboxylic acids (hydrazinocarboxylic acids) and esters (benzene compounds)Q 0440

35 - 134Application of Enantiopure Templated Azomethine Ylids to β-Hydroxy-α-amino Acid Synthesis. — Treatment of the morpholinone(I) with aldehydes leads to azomethine ylids which undergo efficient and highlydiastereocontrolled cycloaddition with a second molecule of aldehyde to affordproducts of type (IV). The products can easily be transformed into pure threoβ-hydroxy-α-amino acids. — (ALKER, D.; HAMBLETT, G.; HARWOOD, L.M.; ROBERTSON, S. M.; WATKIN, D. J.; WILLIAMS, C. E.; Tetrahedron54 (1998) 22, 6089-6098; Dep. Chem., Univ. Reading, Whiteknights, Reading,Berkshire RG6 2AD, UK; EN)

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