Center for the Neurobiology of Addiction Treatment Overview Wake Forest University Health Sciences Established: 1991 Wake Forest School of Medicine 2015 Monitoring the Future Study Prevalence of Past Year Drug Use 12 th Graders Treatment Medications Alcohol60.2Campral, Revia Marijuana35.1None Narcotics6.1Methadone, Suboxone Cigarettes (past 30 days) 13.6NRT, Chantix, Welbutrin Amphetamines8.1None MDMA (Ecstasy)3.6None Cocaine2.6None Ritalin1.8None Cost to US Economy of Addiction: $712 billion Special Relevance to WFBMC Approximately 200 patients per day in WFBMC with substance-related complications 30% of hospital admissions are alcohol/drug related 45% of ED admissions are alcohol/drug related DSM-V: The essential feature of a substance use disorder is a cluster of cognitive, behavioral, and physiological symptoms indicating that the individual continues using the substance despite significant substance- related problems. Suboxone outsells Aderall and Viagra SPECIFIC AIMS 1.To provide a novel mechanism of interaction among NIDA investigators at WFU to examine neurobiological mechanism of cocaine pharmacotherapies. 2.To provide a formal structure of collaborative interactions between our Center and our clinical partners at NIDA-funded clinical centers. 3.To provide a focus for the training of students and postdoctoral fellows in contemporary methods for investigating the neurobiological basis of drug abuse. 4.To serve as an informational source to both the lay and scientific community on issues related to the neurobiology of drug abuse. CNAT Structure Project 1: Behavioral Evaluation of Novel Pharmacotherapies Animal models, cognition, telemetry, medication development Michael Nader, Paul Czoty, Jeff Martin, Mark Ferris, Holden Ko, Daniel Yohannes Project 2: Brain Functional Evaluation of Novel Pharmacotherapies PET imaging, microdialysis, voltammetry, multi-unit neural recording Linda Porrino, Sara Jones, Sam Deadwyler, Robert Hampson Project 3: Molecular/Biochemical Evaluation of Novel Pharmacotherapies Receptor pharmacology, neural signaling, gene therapy Allyn Howlett, Steve Childers, Rong Chen Tissue Core Clinical Centers: Baylor Coll Med U Pennsylvania Pilot Grant Core The Specific Aims are: 1. To solicit and review pilot project proposals. 2. To provide mentorship to ensure further training and career development of investigators receiving pilot funds, particularly new and early stage investigators. 3. To provide support for highly innovative preliminary studies from established investigators. 4. To encourage submission of R01 or other grant applications based on results from pilot studies. Rong Chen, Mark Ferris, Holden Ko, Daniel Yohannes Pilot Core: Sara Jones, PI CNAT Outreach 1.Brain Awareness Week 2.Kernersville Cares For Kids 3.WSSU Summer Science Scholars Program 4.Treatment and Prevention Practitioners: Provide training to NC Parent Network 5.Youth Education 6.Interactions with journalists Center for the Neurobiology of Addiction Treatment CNAT Psychiatr y Primate Center Neurobiol/ Anat Phys/Phar m PHS WFI Radiology Sticht Center CTSI Anesthes- iology Pilot Funding Roundtable Discussion Leader: Lynne Wagenknecht, DrPH Wake Forest Baptist Medical Center 11 Pilot Funding Opportunities - Centers PILOT FUNDING OPPORTUNITIES PILOT DESCRIPTIONAMOUNTTARGETED DATE FOR SUBMISSION CCC - Push Pilots (one per CCC Program)$40,000/each9/9/15; now under review CCMR - Animal research pilots$5,000 each (3)November 30, 2015 CIIRRC - Pilot Awards$6,000 eachAugust (2 planned 2016) CPHG - Planned pilot awards annuallyTBDMarch (1 planned 2016) HVRC - Pilot Funding$3,000-$4,000 eachrolling submissions throughout year MACHE - Health Disparities/Health Equity$25,000 (1)FY16 (date TBD) MACHE - Travel Awards$1,500 each (5 awards)3 months prior to travel date Wake Forest Baptist Medical Center 12 Pilot Funding Opportunities - Institutes PILOT FUNDING OPPORTUNITIES PILOT DESCRIPTIONAMOUNTTARGETED DATE FOR SUBMISSION CTSI - Clinical Informatics Pilot$40,000 (1)11/11/15 (based on invite from LOI) CTSI - Community Engagement Pilot$40,000 (1)11/11/15 (based on invite from LOI) CTSI - Ignition Fundup to $5,000 monthly Oct 2015-June 2016 CTSI - Implementation Science Pilot$40,000 (1)11/11/15 (based on invite from LOI) CTSI - Open Pilot$40,000 (4)11/11/15 (based on invite from LOI) CTSI - Open Pilots$40,000 (4)Spring 2016 CTSI - Targeted Pilots$40,000 (4)Spring 2016 WFI - Commercialization Pathway Awards. To fund early product ideas Approximately between $5,000 and $40,000 Rolling submission of RFAs WFI - Technology Development Program. To finance milestone-based development of innovative technologies to point of licensing Up to $15 million over the next 3-5 years Submission details to be announced shortly see Your.WakeForestInnovations.com Wake Forest Baptist Medical Center Discussion Discussion Leader: Lynne Wagenknecht, DrPH