Cell-Mediated CytotoxicityCytotoxic T-Lymphocytes

Natural Killer Cells

Antibody-Dependent, Cell-mediated Cytotoxicity

Delayed-type Hypersensitivity

Folder Title: CellKill

KillTitl

Updated: November, 25, 2004

Cell-Mediated Immunity (CMI):Passive transfer from donor to recipient of cells alone, transfers the immune response function

Response to:

Neoplastic (cancer) Cells

Infected or Altered Cells

Intra-cellular Pathogens

Fungi

Allo-grafts and other transplants

CMIRoles

Cell-Mediated Immunity (CMI):Types of Cytotoxic Cells

Antigen-Specific T-Cells (Have TCR): Tc : Cytotoxic T-Cells TDTH : Delayed-Type Hypersensitivity Cells ("Type IV Hypersensitivity")

Non-Antigen-Specific Cells: Macrophages NK Cells Granulocytes: Neutrophils, Eosinophils, Basophils and Tissue Mast Cells

CMICells

CTL Antigen Recognition

CD4 & CD8 Sensitize & Effect

CTL Sensitizaton Phase

CTL & MHC

Effector Phase by CTL

CTL & ICAM-1

CTL binding to Target Cell

Cytotoxic T-Cell Binding to Target Cell(figure 16-6, Kuby, 3rd Edition)

TC = Target Cell for Cytolytic T-Cell

Smaller Cell = CTL

CTLandTC

CTL Perforin Pore

T-Cell Killing by Induction of Apoptosis(figure 16-8, Kuby, 3rd Edition)

ICE = Interleukin 1Converting Enzyme

Signals Activationof Apoptosis

CTL&Apop

T-Cell and NK Cell Development

Comparison of T- and NK Cells

Natural Killer Cell Targets and Restriction to Altered-Self(Figure 16-11, Kuby, 3rd Edition)

No Killing

(Recognized Self;

MHC Class I)

Target Cell Killed

(Did not recognize self;

low MHC Class I

NKTarget

ADCC Targets

CD28 – B7 Co-stimulators

B7 Melanoma Vaccine