calcium cycling in cardiac cells lin guo-hua. cardiac e-c coupling

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Calcium Cycling in Cardiac Cells Lin Guo-hua

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Page 1: Calcium Cycling in Cardiac Cells Lin Guo-hua. Cardiac E-C coupling

Calcium Cycling in Cardiac Cells

Lin Guo-hua

Page 2: Calcium Cycling in Cardiac Cells Lin Guo-hua. Cardiac E-C coupling

Cardiac E-C coupling

Page 3: Calcium Cycling in Cardiac Cells Lin Guo-hua. Cardiac E-C coupling

Slow or L-type Ca2+ Channels (DHPRs)

Page 4: Calcium Cycling in Cardiac Cells Lin Guo-hua. Cardiac E-C coupling

L-type Ca2+ Channels

Page 5: Calcium Cycling in Cardiac Cells Lin Guo-hua. Cardiac E-C coupling

Ca2+ Release Channel of the Sarcoplasmic Reticulum (Ryanodine Receptor)

Page 6: Calcium Cycling in Cardiac Cells Lin Guo-hua. Cardiac E-C coupling

cardiac ryanodin receptor

Page 7: Calcium Cycling in Cardiac Cells Lin Guo-hua. Cardiac E-C coupling

Physiological and pathophysiological regulation

Page 8: Calcium Cycling in Cardiac Cells Lin Guo-hua. Cardiac E-C coupling

Ca2+ Pump of the Sarcoplasmic Reticulum

(SERCA)

Page 9: Calcium Cycling in Cardiac Cells Lin Guo-hua. Cardiac E-C coupling

SERCA

Page 10: Calcium Cycling in Cardiac Cells Lin Guo-hua. Cardiac E-C coupling

SERCA-PLN complex

Page 11: Calcium Cycling in Cardiac Cells Lin Guo-hua. Cardiac E-C coupling

Phospholamban (PLN)

&Sarcolipin

(SLN)

Page 12: Calcium Cycling in Cardiac Cells Lin Guo-hua. Cardiac E-C coupling

The Ca2+ Pump of the PlasmaMembrane (PMCA)

Page 13: Calcium Cycling in Cardiac Cells Lin Guo-hua. Cardiac E-C coupling

Sodium/Calcium Exchanger (NCX)

Page 14: Calcium Cycling in Cardiac Cells Lin Guo-hua. Cardiac E-C coupling

Troponin C (TnC)

Page 15: Calcium Cycling in Cardiac Cells Lin Guo-hua. Cardiac E-C coupling

Calmodulin (CaM)

Page 16: Calcium Cycling in Cardiac Cells Lin Guo-hua. Cardiac E-C coupling

Calmodulin (CaM) &

Calmodulin Kinase II (CaMKII)

Page 17: Calcium Cycling in Cardiac Cells Lin Guo-hua. Cardiac E-C coupling

Calmodulin Kinase II (CaMKII)

Page 18: Calcium Cycling in Cardiac Cells Lin Guo-hua. Cardiac E-C coupling

Regulation of Ca Transporters by CaM and CaMKII

Page 19: Calcium Cycling in Cardiac Cells Lin Guo-hua. Cardiac E-C coupling

frequency-dependent acceleration of relaxation (FDAR)

Page 20: Calcium Cycling in Cardiac Cells Lin Guo-hua. Cardiac E-C coupling

Calsequestrin (CSQ)

Page 21: Calcium Cycling in Cardiac Cells Lin Guo-hua. Cardiac E-C coupling

Organization of EC coupling elements

Page 22: Calcium Cycling in Cardiac Cells Lin Guo-hua. Cardiac E-C coupling
Page 23: Calcium Cycling in Cardiac Cells Lin Guo-hua. Cardiac E-C coupling

Integrative Analysis of Calcium Cycling in Cardiac Muscle

Page 24: Calcium Cycling in Cardiac Cells Lin Guo-hua. Cardiac E-C coupling

[Ca2+]i Transient in Heart Cell

Page 25: Calcium Cycling in Cardiac Cells Lin Guo-hua. Cardiac E-C coupling

[Ca2+]I Transient

[Ca2+]i sparks

&

Page 26: Calcium Cycling in Cardiac Cells Lin Guo-hua. Cardiac E-C coupling
Page 27: Calcium Cycling in Cardiac Cells Lin Guo-hua. Cardiac E-C coupling

Ca2+ Requirements for Activation of Myofilaments

Page 28: Calcium Cycling in Cardiac Cells Lin Guo-hua. Cardiac E-C coupling

Autoregulation of SR Ca2+ Content

Page 29: Calcium Cycling in Cardiac Cells Lin Guo-hua. Cardiac E-C coupling

Changes of sarcolemmal fluxes and SR CaCa2+ release during potentiation of CICR by caffeine (500 mmol/L)

Modulation of the RyR

Page 30: Calcium Cycling in Cardiac Cells Lin Guo-hua. Cardiac E-C coupling

relationships between the various Ca2+ fluxes

Page 31: Calcium Cycling in Cardiac Cells Lin Guo-hua. Cardiac E-C coupling

Ca2+ Influx During the Cardiac AP

Page 32: Calcium Cycling in Cardiac Cells Lin Guo-hua. Cardiac E-C coupling

Ca2+ Removal From the Cytosol During

Cardiac Relaxation

Page 33: Calcium Cycling in Cardiac Cells Lin Guo-hua. Cardiac E-C coupling

Frequency-dependent changes in the fraction of Ca release that is taken back up by the SR

Page 34: Calcium Cycling in Cardiac Cells Lin Guo-hua. Cardiac E-C coupling

Measurement of SR Ca2+ content and forcefrequency relationship.

Page 35: Calcium Cycling in Cardiac Cells Lin Guo-hua. Cardiac E-C coupling

force frequency relation

Page 36: Calcium Cycling in Cardiac Cells Lin Guo-hua. Cardiac E-C coupling

Frequency-dependence of isometric twitch force (twitch) and rapid cooling contractures (RCC) in nonfailing and failing human myocardium

Page 37: Calcium Cycling in Cardiac Cells Lin Guo-hua. Cardiac E-C coupling

Relationship between NCX and SERCA protein levels and in non-failing and failing human myocardium

Page 38: Calcium Cycling in Cardiac Cells Lin Guo-hua. Cardiac E-C coupling

Caffeine contractures in isolated rabbit myocytes following adenoviral gene transfer of LacZ and NCX

Page 39: Calcium Cycling in Cardiac Cells Lin Guo-hua. Cardiac E-C coupling

Frequency-dependent changes in twitch force, aequorin light signals RCCs in huma atrial muscles (A) and ventricular muscles (B).

Page 40: Calcium Cycling in Cardiac Cells Lin Guo-hua. Cardiac E-C coupling

Steady-state twitches, postrest twitches, and RCCs in isolated human atrial myocardium.

Page 41: Calcium Cycling in Cardiac Cells Lin Guo-hua. Cardiac E-C coupling

Rapid Cooling Contracture

Page 42: Calcium Cycling in Cardiac Cells Lin Guo-hua. Cardiac E-C coupling

Paired RCCs and Ca2+ Reuptake Into the SR

Page 43: Calcium Cycling in Cardiac Cells Lin Guo-hua. Cardiac E-C coupling

Rest-dependent changes in the amplitudes of twitch force and RCCs) in human atrial myocardium (A) and ventricular muscles (B)

postrest potentiation & postrest decay

Page 44: Calcium Cycling in Cardiac Cells Lin Guo-hua. Cardiac E-C coupling

restitution

postextrasystolic potentiation

Page 45: Calcium Cycling in Cardiac Cells Lin Guo-hua. Cardiac E-C coupling

Ca2+ Restitution of the Ca transient

Page 46: Calcium Cycling in Cardiac Cells Lin Guo-hua. Cardiac E-C coupling