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Working Across SCOR, BIRCWH and CTSA

Programs: Interdisciplinary Synergy

Kathleen Brady, MD, PhDAssociate Dean for Clinical and Translational

ResearchMedical University of South Carolina

MUSC Specialized Center for Translational Research (SCOR)

Funded 2002-?????

Research focus: gender differences in substance use / stress response Translational research teams

Second aim: to encourage growth of gender-based research campus-wide

Specific Aim

To build a multi-disciplinary, translational program of research focused on gender-related issues in stress and substance use disorders at MUSC

Strategies

Link with other programs

Bring in seasoned investigators

Build critical mass

Building Basic-Clinical Research Bridges: The Whole is Greater

than the Sum of the Parts

Each project with unique focus, but interdependent, cross-talk, iterative process medications studies gonadal hormone findings pharmacologic stressors impulsivity studies adverse childhood experiences

Bridging Basic and Clinical Research Projects

Parallel testin the animal model

established and applied

Stress enhances impulsivity in human laboratory paradigm

Test of novel pharmacotherapy for

stress-enhanced impulsivity

Test of novel pharmacotherapy for

in human subjects

Imaging of brain changes produced by pharmacotherapy for

cognitive deficit

In vivo modulation of identified brain regions

in the animal model

Two basic science, two clinical projects : projects unique, but interdependent, cross-talk, iterative development

Specific Aim

To encourage the growth of gender-based research throughout the MUSC campus Pilot project program Interaction with Women Scholars

Initiative Interaction with centers throughout

MUSC campus

Pilot Project Program

Funded by COM Dean of College and University Provost

Received approximately 300 applications from every college and multiple departments, funded over 60 projects

Has resulted in collaborations/gender-based research : Aging Center Ob-Gyn Hollings Oncology Center Crime Victims Center Pediatrics Center for Advanced Imaging Research Alcohol Research Center Pain Clinic - Anesthesiology

Specific Aim

To attract and mentor young investigators and new investigators in the area of research, particularly patient-oriented research, in women’s health issues

Interaction with Training Programs

Post-Doctoral Fellowships in Alcohol and Drug Abuse: Translational Research

Drug Abuse Research Training

SPCTR: Roadmap Initiative focused on pre-doctoral research training

Master’s Training in Clinical Research

Neuroscience Graduate Program NIMH-funded course in Biology of Neurologic and

Neuropsychiatric Disease

Psychology Internship Program

Submitted K-12 application: BIRWCH

MUSC BIRCWH

•Awarded September, 2007

•Clinical and basic science scholars funded for 2-3 years each

•Focus on gender differences in• Aging/ Cognitive decline• Addictions/ Mental health• Neuroscience

Areas of Overlap SCOR/BIRCWH

Monthly seminar series – SCOR investigators, BIRCWH scholars and mentors Foster and model interdisciplinary “cross-talk”

Monthly journal club

BIRCWH Scholars work on SCOR projects

Collaboration across BIRCWH projects – basic/clinical interaction

Pilot project funds

CTSA : Institutional Home for Clinical and Translational Science

Healthcare organizations

CTSA MISSION

To facilitate clinical and translational research by providing research support services,

research training and improving access to research-related resources.

CTSA Mission

Tremendous overlap with SCOR/BIRCWH – opportunity to leverage CTSA resources for program enhancement

SOCRATES – K-awardee “club”

Annual Mentorship retreat

Pilot project program

Thematic Research Retreats

STAR consultations

Core support/Research navigation

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CTSAResearch Resources

Tech TransferRegulatory & Bioethics

SCOR BIRCWH

InterdisciplinaryTraining/

MentoringPilot Projects

WOMEN’S HEALTHJournal Club

Seminar Series

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Opportunities to Expand Funding

CONCLUSIONS

Advocacy/awareness critical

Find out about CTSA resources

Leverage existing strengths Partner with existing centers,

programs Recruit “seasoned” investigators to

explore gender differences

Work across mentorship/training programs