BOOK AVAILABLE WITH LATEST DATA ON PLURONIC POLYOLS' LOW ORDER OF TOXICITY
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BOOK AVAILABLE WITH LATEST DATA ON
PLURONIC POLYOLS' LOW ORDER OF TOXICITY BASF Wyandotte Corporation has been accumulating data on the toxicological properties of the Pluronic series of polyols since 1952. The most recent findings are now available in an updated edition of BASF Wyandotte's book, "Pluronic Polyols Toxicity and Irritation Data."
Among the topics discussed are toxicological, dermatological, chemical, physical and surface active properties; 90-day subacute, target organ and reproductive studies; skin irritation and eye sensitivity tests are also covered.
Target organ studies show grades tested produced no adverse reactions from ingestion of the test materials. Pluronic polyols, in concentrations up to 10% and higher, were safely tolerated in food mixtures. And in a three-generation reproduction study, Pluronic L101 and Pluronic F108 were administered in the diets of rats . . . neither material appeared to affect growth or ability to produce normal offspring.
The compiled data demonstrate the Pluronic polyols' freedom from hazardous toxicological or irritating properties. In fact, the Pluronic polyols have such a low order of toxicity that many have been approved by the FDA* for both direct and indirect food applications. Their use is, therefore, suggested for further consideration in such areas as cosmetics, pharmaceuticals and drugs.
The new book also contains a bibliography of 186 articles written on many Pluronic uses in the pharmaceutical industry, covering such varied applications as fatty emulsions, tablet coatings, defoaming and many more. Further listed are 70 patents that have already been granted for the use of Pluronic polyols in such products as stool softeners, ear drops, mouthwashes, gels, hair products and antibiotics.
Generically classified as poly(oxypropylene)-poly(oxyethylene) gly-cols, this exclusive series of nonionic surfactants is commercially available in 32 grades. These grades find application as solubilizers, emulsifiers, defoaming, dedusting, wetting and cleansing agents as well as in other surfactant applications.
For your copy of this helpful book, address Department CO.
Though tradenames are not used by FDA, approved uses of Pluronic polyols as food additives are covered under the following FDA regulations: 120.1001; 121.1235; 121.2507; 121.2519; 121.2520; 121.2526; 121.2534; 121.2541; 121.2543; 121.2547; 121.2550; 121.2557; 121.2571. Details of this list are available upon request.
TO PACE GROWING URETHANE MARKETS . . .
BASF WYANDOTTE PLANS NEW POLYOL PLANT Construction has begun on a new polyether polyols production unit at BASF Wyandotte's Geismar, Louisiana complex with completion scheduled for mid-1972. This computer-controlled plant will utilize a number of patented process features and will have an initial capacity of more than 100 million pounds per year, with provisions to double the capacity when required. The initial product line will include polyols used extensively in the formulation of flexible urethane foams, which are widely used in furniture, bedding and automotive applications.
BASF Wyandotte Corporation Wyandotte, Michigan 48192
FEB. 22, 1971 C&EN
Chemicals OutlookPLURONIC POLYOLS' LOW ORDER OF TOXICITY