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What is Bone Marrow?

The spongy tissue in the cavities of the bones is known as the bone marrow.

It acts as the blood cell factory releasing blood cells when it is required.It consists of Red Blood Cells, White Blood Cells and Platelets

How does bone marrow helps us?

Red blood cells in the marrow carries oxygen to the cells

Platelets help prevent bleeding and aid in clotting of blood.

Granulocytes and macrophages fight infections from bacteria, fungi, and other parasites. They also remove dead cells and remodel tissue and bones.

B-lymphocytes produce antibodies while T-lymphocytes can directly kill or isolate invading cells.

Red Blood Corpuscles live for around 170 days and need to be replenished continuously. An average human requires approximately one hundred billion new hematopoietic cells each day produced by the Hematopoietic Stem Cells (HSCs)

Need for Bone Marrow TransplantVarious illnesses and treatments can destroy the bone marrow leaving the

person unable to make the new blood cells needed to fight infection and recover. Damaged or diseased stem cells can make too few blood cells, too few immune cells, or too many abnormal cells. Any of these problems can cause the body to not have enough normal red blood cells, white blood cells, or platelets.

There are a number of diseases affecting the bone marrow like:

1) Leukaemia – a cancer of the blood that starts in the bone marrow2) Reticulum cell sarcoma of bone - a cancerous tumor of the bone marrow,

occurring more often in males than in females3) Aplastic anaemia - Here a person stops making blood.4) Defective immune system - Some children are born with a defective immune

system and are unable to fight disease. Bone Marrow transplant becomes the only way to cure the disease.

Types of Bone Marrow Transplant

Here stem cells are removed from the patient before high-

dose chemotherapy or radiation treatment. After chemotherapy your stems cells are put back in your

body to make (regenerate) normal blood cells

Stem cells are removed from a newborn baby's umbilical cord right after birth. The stem cells

are frozen and stored until they are needed for a

transplant. These cells are very immature so there is less

of a need for matching.

AllogeneicTransplants

Umbilical cord blood

transplant

Autologous Transplants

Stem cells are removed from another person, called a donor.

Donor's genes must at least partly match your genes, which

are decided through special blood tests. Brother, sister, parents, children are most likely to be a good match.

Stem Cells are entered into the blood stream through a tube called Central Venous catheter, just like getting a blood transfusion.

. The stem cells travel through the blood into the bone marrow.

How can the Donor Cells be collected?

Bone marrow harvest

Bone marrow is removed from the back of both hip

bones as the patient is asleep and pain free during

that time

Donor given 5 days of shots. Stem cells are

moved from bone marrow to blood. Blood is them removed from donor through IV Line

in a vein.

Leukapheresis

The part of white blood cells that contains stem cells is then

separated in a machine and removed to be later given to the recipient. The red blood cells are

returned to the donor.

Infection

Low platelets and low red blood cells

Pain

Fluid overload

Organ damage

Graft failure

Graft-versus-host disease

Respiratory distress

High Beam Global, India’s largest medical assistance

company

Brings to youBone Marrow Transplant at an affordable

cost in India

To know more about us kindly visit our website:

WWW.hbgmedicalassistance.com