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  • Bolile ficatului, colecistului i pancreasului.

    ,

    .

    Disorders of the liver, gallbladder and pancreas.

  • Tema: Bolile ficatului, cilor biliare i pancreasului.

    I. Micropreparate:

    89. Distrofia toxic acut a ficatului. (coloraie H-E). Indicaii:

    1. Focar extins de necroz (detritus) n centrul lobulului hepatic.

    2. Infiltrat inflamator n zona de necroz.

    3. Distrofia gras a hepatocitelor la periferia lobulului.

    209. Hepatit viral acut. (coloraie H-E). Indicaii:

    1 .Distrofia hidropic vacuolar a hepatocitelor zonelor periferice ale lobulului hepatic.

    2. Infiltraia limfo-plasmocitar a tractelor portale.

    37. Ciroza micronodular a ficatului. (coloraie picrofuxin (van Gieson)). Indicaii:

    1. Fascicule subiri de esut fibroconjunctiv n lobulii hepatici, care unesc venele

    centrale cu vasele portale.

    2. Pseudolobuli.

    157. Carcinom hepatocelular pe fond de ciroza hepatic. (coloraie H-E). Indicaii:

    1. Aglomerri de celule atipice polimorfe cu bazofilia nucleilor.

    2. esutul hepatic adiacent cu modificri cirotice.

    II. Macropreparate:

    72. Necroz masiv a ficatului (distrofie toxic).

    73. Ciroz hepatic micronodular.

    74. Metastaze de cancer n ficat.

    76. Calculi n vezicula biliar.

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  • Pathology of the liver, gallbladder and pancreas.

    I. Microspecimens:

    89. Acute massive necrosis of liver. (H.E. stain).

    Indications:

    1. The extensive area of necrosis (tissue debris) in the center of the liver lobule.

    2. The inflammatory infiltrate in the area of necrosis.

    3. Fatty degeneration of hepatocytes at the periphery of the lobule.

    209. Acute viral hepatitis. (H.E. stain).

    Indications:

    1. Vacuolar degeneration of hepatocytes at the periphery of the lobule.

    2. Lymphocytic and plasmacytic infiltration of portal tracts.

    37. Liver micronodular cirrhosis. (pycrofuxin by van Gieson method stain).

    Indications:

    1. Thin bundles of connective tissue in the liver lobules, which join together the central veins with portals

    vessels.

    2. "Pseudolobules".

    157. Hepatocellular carcinoma on the background of liver cirrhosis. (H.E. stain).

    Indications:

    1. Clusters of polymorphic atypical cells with basophilic nuclei.

    2. Adjacent liver tissue with cirrhotic changes.

    II. Macrospecimens:

    72. Acute massive necrosis of liver.

    73. Micronodular liver cirrhosis.

    74. Cancer metastasis into liver.

    76. Gallstones in the gallbladder.

  • Patternele leziunii hepatice

    Zonal Toxine/Hipoxie

    n punte Viral sever

    Interfa Imun

    Apoptotic - Viral

  • Necroz masiv

    a ficatului

    (distrofie toxic).

  • 89. Distrofia toxic acut a ficatului. (coloraie H-E).

    3

    1 2

  • Steatoza ficatului.

  • Hepatita acut vs. cronic.

  • Hepatit viral,distorfie hidropic i corpusculi

    Councilman ,

    infiltraia limfoid a tractelor portale

    (necroz periportal parcelar)

  • Hepatocite de sticl

    mat cu citoplasma

    omogenizat (acumulri masive de HBsAg)

    Ground glass

    hepatocytes with

    homogenous cytoplasm

    (massive accumulation of HBsAg)

    Fragmente rotunde

    eozinofile de hepatocite

    apoptozice corpusculi Councilman

    Rounded eosinophil

    fragments of apoptotic

    hepatocyte Councilman bodies

  • 209. Hepatit viral acut. (coloraie H-E).

    2

    1

  • Hepatit alcoolic,

    steatoz i corpusculi Mallory

  • Ciroz macro- (a, b) i micronodular (c, d).

    a

    b

    c

    d

  • Ciroz hepatic,

    aspecte microscopice.

  • 37. Ciroza micronodular a ficatului. (coloraie picrofuxin (van Gieson)).

    2

    1

  • Dilatarea varicoas a

    venelor esofagiene i a peretelui abdominal anterior

  • Splenomegalie.

    Icter.

  • Calculi i staz biliar

    n ficat.

  • Carcinom hepatic nodular.

  • 157. Carcinom hepatocelular pe fond de ciroza hepatic. (coloraie H-E).

    1

    2

  • Metastaze de

    carcinom n ficat.

  • Pancreatita acut.

    Pancreatita cronic.

  • Colesteroloza mucoasei vezicii biliare.

  • Calculi n vezicula biliar.