BME 130 – Genomes

Lecture 7

Genome Annotation I –Gene finding &

function predictions

Figure 5.1 Genomes 3 (© Garland Science 2007)

Figure 5.2 Genomes 3 (© Garland Science 2007)

Figure 5.3 Genomes 3 (© Garland Science 2007)

Figure 5.4 Genomes 3 (© Garland Science 2007)

Exon and Intron length distribution in the human genome

Figure 5.5 Genomes 3 (© Garland Science 2007)

Figure 5.6a Genomes 3 (© Garland Science 2007)

Figure 5.6b Genomes 3 (© Garland Science 2007)

Figure 5.7 Genomes 3 (© Garland Science 2007)

Figure 5.8 Genomes 3 (© Garland Science 2007)

Comparative genomics

synteny

Figure 5.9 Genomes 3 (© Garland Science 2007)

Is this short ORF a gene?

Figure 5.10 Genomes 3 (© Garland Science 2007)

mRNA5’ UTR 3’ UTR

coding sequence (CDS)

Genomic DNA

Figure 5.13 part 1 of 2 Genomes 3 (© Garland Science 2007)

5’ RACE

Figure 5.13 part 2 of 2 Genomes 3 (© Garland Science 2007)

5’ RACE

Figure 5.15 Genomes 3 (© Garland Science 2007)

How to learn a gene’s function

Figure 5.16 Genomes 3 (© Garland Science 2007)

Figure 5.17 Genomes 3 (© Garland Science 2007)

Figure 5.18 Genomes 3 (© Garland Science 2007)

Figure 5.19 Genomes 3 (© Garland Science 2007)

Table 5.1 Genomes 3 (© Garland Science 2007)

Figure 5.20 Genomes 3 (© Garland Science 2007)

Figure 5.21 Genomes 3 (© Garland Science 2007)

Figure 5.22 Genomes 3 (© Garland Science 2007)

Figure 5.23 Genomes 3 (© Garland Science 2007)

Figure 5.24 Genomes 3 (© Garland Science 2007)

Table 5.2 part 1 of 2 Genomes 3 (© Garland Science 2007)

Table 5.2 part 2 of 2 Genomes 3 (© Garland Science 2007)

Figure 5.25 Genomes 3 (© Garland Science 2007)

Technical Note 5.2 Figure T5.2 Genomes 3 (© Garland Science 2007)

Figure 5.26 Genomes 3 (© Garland Science 2007)

Table 5.3 Genomes 3 (© Garland Science 2007)

Figure 5.28 Genomes 3 (© Garland Science 2007)