Blood

Blood is:55% Plasma45% CellsWhat is plasma?

Plasma is theliquid portionof blood

Plasma is:

91.5% water. Transport medium.

7% proteins, e.g., clotting factors, antibodies

1.5% other solutes, e.g., hormones,vitamins, amino

acids, glucose, fatty acids, nitrogen wastes,

electrolytes (Ca++, Na+, K+, H+)

What kinds ofcells do we findin the blood?

Red Blood Cells (RBCs) = Erythrocytes

• >99% of total blood cells are RBCs

• ~5 million/ml

• Hb• Fe

• Transport O2 and CO2

• No nucleus when mature

Platelets = Thrombocytes

• Involved in blood clotting

• 150,000 – 400,000/ml

White Blood Cells (WBCs) = Leukocytes

Defense system

5,000 – 10,000/ml

There are 5 different types of WBCs

Neutrophils = PMNs = Polymorphonucleocytesor Poly’s

• Most abundant ofthe WBCs

• Phagocytic

• Kill bacteria

Basophils

• Release histamine.

• Their numbers increasein allergic reactions

Eosinophils

• Fight parasitic infections

• Some allergic reactions,esp. asthma, are theresult of the malfunction-ing of eosinophils.

Lymphocytes

• Produce antibodies

• Fight viruses

What % of blood is plasma?

A.) 65

B.) 45

C.) 55

D.) 90

Monocytes

• Size-wise, is largestof the WBCs• Phagocytic

• Large kidney-shapednucleus

The blood cell that releases histamine in an allergic reaction is

A.) neutrophil

B.) basophil

C.) esinophil

D.) lymphycyte

Important Hematology Lab Terms

1. CBC = Complete Blood Count

Normal (nl) values:RBCs: 4.2-5.9 million/mlWBCs: 5,000-10,000/mlPlatelets: 100,000 – 400,000/ml

CBC c diff (differential)

Nl values:PMNs: 60-70%Lymphos: 20-25%Monos: 3-8%Eos: 2-4%Basos: 0.5-1%

Hematocrit (or ‘crit, if you want to sound cool)

The percent of whole blood made up of redblood cells.

Nl value: 40-50%

Let’s run a virtualhematocrithttp://scienceu.fsu.edu/content/virtuallab/hematology/docs/hematocrit.html

Hemoglobin – Hb

Do you remember what hemoglobin is?

A nl hemoglobin value is 12-16g/dl

WBC that fight viruses are

A.) Esinophils

B.) Lymphocytes

C.) Basophils

The most abundant kind of Leukocytes are

A.) Netrophils

B.) Basophils

C.) Monophils

D.) Esinophils

How many kinds of leukocytes are there

A.) 4

B.) 5

C.) 2

D.) 3

The largest WBC is

A.) Neutophils

B.) Basophils

C.) Monocytes

D.) Esinophils