Biomedical Engineering (BME)           1

BIOMEDICAL ENGINEERING (BME)BME 100Introduction to the ProfessionIntroduces the student to the scope of the biomedical engineeringprofession and its role in society, and develops a sense ofprofessionalism in the student. Provides an overview of biomedicalengineering through lectures, presentations by outside speakers,hands-on exercises, and scientific literature analyses. Developsprofessional communication and teamwork skills.Lecture: 1 Lab: 2 Credits: 2Satisfies: Communications (C)

BME 200Biomedical Engineering Application of MATLABThis course will provide students an opportunity to learn how touse the MATLAB programming environment to solve biomedicalengineering problems. Students will learn basic MATLAB functionsfor importing, analyzing, visualizing, and exporting data, as well ascomputational techniques for modeling and solving quantitativeengineering problems. Examples will be taken from the three areasof specialization offered in the biomedical engineering department-- cell and tissue engineering, neural engineering, and medicalimaging.Prerequisite(s): MATH 252* and CS 115, An asterisk (*) designates acourse which may be taken concurrently.Lecture: 1 Lab: 3 Credits: 2

BME 301Bio-Fluid MechanicsBasic properties of fluids in motion. Lagrangian and Eulerianviewpoints, material derivative, streamlines. Continuity, energy,angular and linear momentum equations in integral and differentialforms. Applications in biofluids and biomedical devices; rheology ofbiological fluids.Corequisite(s): BME 320Prerequisite(s): MATH 251 and MMAE 200 and BIOL 115Lecture: 3 Lab: 0 Credits: 3

BME 309Biomedical ImagingAn introduction to biomedical imaging concepts and modalities.Topics covered include general principles of image science (imagequality, sampling, etc.), X-ray-based imaging [conventional x-rayimaging, mammography, computed tomography (CT), and digitalsubtraction angiography (DSA)], and nuclear medicine [gammacamera, single photon emission computed tomography (SPECT),and positron emission tomography (PET)].Prerequisite(s): BME 330* and PHYS 221, An asterisk (*) designatesa course which may be taken concurrently.Lecture: 3 Lab: 0 Credits: 3

BME 310BiomaterialsApplications of biomaterials in different tissue and organ systems.Relationship between physical and chemical structure of materialsand biological system response. Choosing, fabricating, andmodifying materials for specific biomedical applications.Prerequisite(s): CHEM 125 and PHYS 123Lecture: 3 Lab: 0 Credits: 3Satisfies: Communications (C)

BME 315Instrumentation and Measurement LaboratoryLaboratory exercises stress instrumentation usage and dataanalysis used to determine physiological functions and variablesand the relations to the physiological variability.Prerequisite(s): ECE 211* and CS 104, An asterisk (*) designates acourse which may be taken concurrently.Lecture: 1 Lab: 3 Credits: 2Satisfies: Communications (C)

BME 320Fluids LaboratoryLaboratory experiments in thermodynamics, biological fluidflow, and heat transfer. Emphasis is placed on current methods,instrumentation, and equipment used in biomedical engineering; oralpresentation of results; and on the writing of comprehensive reports.Open only to Biomedical Engineering majors.Corequisite(s): BME 301Prerequisite(s): BIOL 117 and BME 315Lecture: 0 Lab: 3 Credits: 1Satisfies: Communications (C)

BME 325Bioelectronics LaboratoryPractical hands on design, construction and testing of electric andelectronic circuitry for biomedical applications. Basic conceptswill be presented with emphasis on their relevance to the design ofsystems that can be used for clinical and basic scientific research.Prerequisite(s): ECE 213 and BME 315Lecture: 0 Lab: 3 Credits: 1

BME 330Analysis of Biosignals and SystemsThis course is a junior level introduction to the theoretical andpractical aspects of signal processing and dynamic systemsbehavior as they relate to physiological, biological, and biomedicalsystems. The topics covered will include sampling theory,continuous and discrete Fourier transforms and series, Laplacetransforms, Linear systems theory, signal filtering, models ofbiological and physiological systems, and analysis of dynamic andfeedback systems.Prerequisite(s): ECE 211 and MATH 252Lecture: 3 Lab: 0 Credits: 3

2        Biomedical Engineering (BME)

BME 331Modeling and Control of Biological SystemsThe course expands upon the systems and signal processingconcepts introduced in BME 330 to develop the tools to modelphysiological processes and the feedback control of theseprocesses.Prerequisite(s): (BME 330 or ECE 308) and BME 422Lecture: 3 Lab: 0 Credits: 3

BME 335Thermodynamics of Living SystemsPrinciples of thermodynamics and conservation of mass appliedto living systems and biomedical devices. The first and secondlaws of thermodynamics, pHs and chemical equilibrium, metabolicstoichiometry and energetics.Prerequisite(s): CHE 202 and BME 301* and MATH 251, An asterisk(*) designates a course which may be taken concurrently.Lecture: 3 Lab: 0 Credits: 3

BME 405Physiology LaboratoryA laboratory course which demonstrates basic concepts ofbioengineering design through experimental procedures involvinghumans and experimental animals. Statistical principles ofexperimental design. Study of possible errors. Experimentsinclude nerve action, electrocardiography, mechanics of muscle,membranes, and noninvasive diagnostics in humans. Open only toBiomedical Engineering majors.Corequisite(s): BME 453Prerequisite(s): BME 315Lecture: 1 Lab: 3 Credits: 2Satisfies: Communications (C)

BME 417Technologies for Treatment of DiabetesStudy of physiological control systems and engineering of externalcontrol of biological systems by focusing on an endocrine systemdisorder -- diabetes. The effects of type 1 diabetes on glucosehomeostasis and various treatment technologies for regulationof glucose concentration. Development of mathematical modelsdescribing the dynamics of glucose and insulin concentrationvariations, blood glucose concentration measurement and inferencetechniques, insulin pumps, and artificial pancreas systems.Lecture: 3 Lab: 0 Credits: 3

BME 418Reaction Kinetics for BMEThis course focuses on analysis of rate data and single andmultiple reaction schemes. Biomedical topics include biologicalsystems, enzymatic pathways, enzyme and receptor-ligand kinetics,pharmacokinetics, heterogeneous reactions, microbial cell growthand product formation, and the design and analysis of biologicalreactors.Corequisite(s): BME 482Prerequisite(s): BIOL 403 and MATH 252 and BME 335Lecture: 3 Lab: 0 Credits: 3

BME 419Introduction to Design Concepts in Biomedical EngineeringIntroduction to Design Concepts in Biomedical Engineering. Thiscourse aims to educate students on project definition, and on thedesign, development and technology transfer of potential biomedicalproducts in the context of the student's major capstone project.Students will learn best practices for designing a marketablemedical device, including the design process from the clinicalproblem definition through prototype and clinical testing to marketreadiness.Prerequisite(s): BME 315 and (BME 320 or BME 325) and BME 422Lecture: 2 Lab: 0 Credits: 2Satisfies: Communications (C)

BME 420Design Concepts in Biomedical EngineeringAn introduction to the strategies and fundamental bioengineeringdesign criteria behind the development of biomedical engineeringsystems and implantable devices that use either synthetic materialsor hybrid (biological-synthetic)systems. Analysis and design ofreplacements for the heart, kidneys, and lungs. Specification andrealization of structures for artificial organ systems. Students will berequired to complete a team-oriented design project in their chosentrack.Prerequisite(s): BME 419Lecture: 3 Lab: 0 Credits: 3Satisfies: Communications (C)

BME 422Mathematical Methods for Biomedical EngineersThis course integrates mathematical and computational tools thataddress directly the needs of biomedical engineers. The topicscovered include the mathematics of diffusion, pharmacokineticmodels, biological fluid mechanics, and biosignal representationsand analysis. The use of MATLAB will be emphasized fornumerically solving problems of practical relevance.Prerequisite(s): MATH 252 and CS 104 and BME 330*, An asterisk (*)designates a course which may be taken concurrently.Lecture: 3 Lab: 0 Credits: 3

BME 423Cell Biomechanics: Principles and Biological ProcessesThis course will provide students an opportunity to learn aboutmechanical forces that develop in the human body and how theycan influence cell functions in a range of biological processesfrom embryogenesis, wound healing, and regenerative medicineto pathological conditions such as cancer invasion. Examples ofresearch methods for investigating cell biomechanics in variousbiological systems will be discussed.Prerequisite(s): BME 301Lecture: 3 Lab: 0 Credits: 3

Biomedical Engineering (BME)           3

BME 424Quantitative Aspects of Cell and Tissue EngineeringThis course is designed to cover fundamentals of cell andtissue engineering from a quantitative perspective. Topicsaddressed include elements of tissue development, cell growthand differentiation, cell adhesion, migration, molecular and cellulartransport in tissues and polymeric hydrogels for tissue engineeringand drug delivery applications.Prerequisite(s): BME 418 and BME 482 and BME 422Lecture: 3 Lab: 0 Credits: 3

BME 425Microfluidics for Biomedical EngineeringThis course will present fundamentals and applications ofmicrofluidic technologies for applications in the broad biomedicalengineering. It will provide a broad view of the field of microfluidicsand a knowledge of relevant fabrication methods and analysistechniques. Microfluidic fabrication techniques, interfacingwith biological materials, and techniques for analyte detectionin microchannels will be emphasized. The course will includeindividual projects and critical paper reviews in which each studentis expected to demonstrate a grasp of basic concepts in microfluidicdesign and fabrication for specific applications.Lecture: 3 Lab: 0 Credits: 3

BME 431Modern Optics and LasersThis is an undergraduate course covering the basics of optics andmodern aspects of the field such as lasers and nonlinear optics.Connections to other fields such as acoustics, microwaves, electron-beam optics, quantum mechanics will be pointed out. The theorywill be supplemented with demonstration experiments of opticalphenomena. Practical problems will be discussed such as thedesign of an optical imaging system or precision interferometry.Prerequisite(s): PHYS 221Lecture: 3 Lab: 0 Credits: 3

BME 433Biomedical Engineering Applications of StatisticsApplication of modern computing methods to the statistical analysisof biomedical data. Sampling, estimation, analysis of variance,and the principles of experimental design and clinical trials areemphasized.Prerequisite(s): MATH 251Lecture: 3 Lab: 0 Credits: 3

BME 437Introduction to Molecular ImagingThis course provides an overview of molecular imaging, asubcategory of medical imaging that focuses on noninvasivelyimaging molecular pathways in living organisms. Topics includeimaging systems, contrast agents, reporter genes and proteins,tracer kinetic modeling. Preclinical and clinical applications will alsobe discussed with an emphasis on cancer and the central nervoussystem.Prerequisite(s): BME 422Lecture: 3 Lab: 0 Credits: 3

BME 438NeuroimagingThis course describes the use of different imaging modalities tostudy brain function and connectivity. The first part of the coursedeals with brain function. It includes an introduction to energymetabolism in the brain, cerebral blood flow, and brain activation.It continues with an introduction to magnetic resonance imaging(MRI), perfusion-based fMRI, BOLD fMRI, fMRI paradigm design andstatistical analysis, introduction to positron emission tomography(PET) and studying brain function with PET, introduction tomagneto encephalography and studying brain function with (MEG).The second part of the course deals with brain connectivity. Itincludes an introduction to diffusion tensor MRI, explanation tothe relationship between the diffusion properties of tissue and itsstructural characteristics, white matter fiber tractography.Prerequisite(s): PHYS 221Lecture: 3 Lab: 0 Credits: 3

BME 439Advanced Medical ImagingThis course introduces advanced clinical imaging modalities,research imaging techniques, and concepts from image scienceand image perception. The first part of the course introduces theperception of image data by human observers and the visualizationof brain structure and function. It includes an introduction tomagnetic resonance imaging (MRI) and a survey of neurologicalimaging via functional MRI (fMRI). The second part of the coursecovers image science, clinical imaging applications, and novelresearch imaging techniques. It includes an introduction to radiationdetection and image quality evaluation, a survey of clinical cases,and an overview of new imaging methods.Prerequisite(s): BME 309Lecture: 3 Lab: 0 Credits: 3

BME 443Biomedical Instrumentation and ElectronicsPrinciples of circuit analysis are applied to typical transducer andsignal recording situations found in biomedical engineering.Prerequisite(s): BME 315 and ECE 211Lecture: 3 Lab: 0 Credits: 3

BME 445Quantitative Neural FunctionComputational approach to basic neural modeling and function,including cable theory, ion channels, presynaptic potentials,stimulation thresholds, and nerve blocking techniques. Synapticfunction is examined at the fundamental level.Prerequisite(s): BME 453Lecture: 3 Lab: 0 Credits: 3

BME 450Animal PhysiologyRespiration; circulation; energy metabolism; temperature regulation;water and osmotic regulation; digestion and excretion; muscle andmovement; nerve excitation; information control and integration;chemical messengers. Emphasis on general principles withexamples drawn from various animal phyla. Same as BIOL 430.Prerequisite(s): BIOL 107 or BIOL 115Lecture: 3 Lab: 0 Credits: 3

4        Biomedical Engineering (BME)

BME 452Control Systems for Biomedical EngineersControl systems design and analysis in biomedical engineering.Time and frequency domain analysis, impulse vs. step response,open vs. closed loop response, stability, adaptive control, systemmodeling. Emphasis is on understanding physiological controlsystems and the engineering of external control of biologicalsystems.Prerequisite(s): BME 330Lecture: 3 Lab: 0 Credits: 3

BME 453Quantitative PhysiologyThis course provides a quantitative approach to fundamentalphysiological principles and systems. The course covers basic cellphysiology, membrane transport, action potentials and excitabletissue, and skeletomuscular, nervous, cardiovascular, respiratory,renal, and endocrine systems.Corequisite(s): BME 405Prerequisite(s): BIOL 115Lecture: 3 Lab: 0 Credits: 3

BME 455Cardiovascular Fluid MechanicsAnatomy of the cardiovascular system. Scaling principles. Lumpedparameter, one-dimensional linear and nonlinear wave propagation,and three-dimensional modeling techniques applied to simulateblood flow in the cardiovascular system. Steady and pulsatileflow in rigid and elastic tubes. Form and function of blood, bloodvessels, and the heart from an engineering perspective. Sensing,feedback, and control of the circulation. Possible project usingcustom software to run blood flow simulations. Same as MMAE 455.Prerequisite(s): BME 301 or MMAE 310 or MMAE 313Lecture: 3 Lab: 0 Credits: 3

BME 475Neuromechanics of Human MovementConcepts from mechanics and neurophysiology will be introducedand employed to analyze and model human movement, especially ofthe extremities. Topics will include forward and inverse kinematicsand dynamics, muscle modeling, and feedback control.Prerequisite(s): BME 330 or ECE 308 or MMAE 305Lecture: 3 Lab: 0 Credits: 3

BME 482Mass Transport for Biomedical EngineersThis course seeks to provide students with an introduction toadvanced concepts of mass transport with an emphasis onbiological systems. Students will be exposed to derivation of theconservation equations for heat, mass, and momentum. Followingderivation of these laws, focus will be placed on mass transportapplications, including diffusion, convection-diffusion, diffusion withreactions, and facilitated diffusion. Students will be able to applymass transport equations to solve problems in biological systems.Corequisite(s): BME 418Prerequisite(s): BME 301 and CHE 202Lecture: 3 Lab: 0 Credits: 3

BME 490Senior SeminarProfessional issues in bioengineering. Role of bioengineersin industry. Professional identity. Structure of bioengineeringindustries and product development process. Job market analysis.Current employment opportunities. Recruiting process andinterview. Analysis of employer. Marketing versus engineering.Management by objective. Role of higher degrees.Lecture: 1 Lab: 0 Credits: 1Satisfies: Communications (C)

BME 491Independent StudyFocused reading and study under the supervision of a BMEfaculty member. A final written report is required to receive credit.**Instructor permission required.**Credit: VariableSatisfies: Communications (C)

BME 492Undergraduate ResearchIndependent research (experimental or theoretical/computational)under the supervision of a BME faculty member. A final writtenreport is required to receive credit. **Instructor permissionrequired.**Credit: VariableSatisfies: Communications (C)

BME 493BME Undergraduate ProjectResearch or design projecting involving 2 or more students undersupervision of a BME faculty member. A final written report fromeach student is required to receive credit. **Instructor permissionrequired.**Lecture: 3 Lab: 0 Credits: 3

BME 497Special ProblemsDesign, development, analysis or research on special topics definedby a faculty member or the department. **Instructor permissionrequired.**Lecture: 0 Lab: 3 Credits: 3