Axial Spondyloarthritis (axSpA)

Global prevalence (%) of AS7

Patients may experience additionaldisease-related manifestations9,10

Prevalence

Estimated prevalence of axSpA in adults aged

is 0.70%*818 to 44 years

References: 1. van der Heijde D, et al. Ann Rheum Dis. 2017. pii: annrheumdis-2016-210770 2. Rudwaleit M, et al. Arthritis Rheum. 2005;52:1000–83. Sieper J, van der Heijde D. Arth Rheum. 2013;65:543–514. Poddubnyy D, et al. Ann Rheum Dis. 2011;70:1369–74 5. Sieper J, Rudwaleit M. Ann Rheum Dis. 2005;64:659–63 6. Sykes MP, et al. Rheumatology 2015;54:2283–47. Stolwijk C, et al. Arthritis Care Res. 2016;68:1320–31

8. Strand V, et al. Arthritis Care Res. 2013;65:1299–306 9. de Winter JJ, et al. Arthritis Res Ther. 2016;18:196 10. Davey-Ranasinghe N, Deodhar A. Curr Opin Rheumatol. 2013;25:509–16 11. Rudwaleit M, et al. Arthritis Rheum. 2006;54:569–78 12. Dougados M, et al. Clin Exp Rheumatol. 2017;35:209–13 13. Leverment S, et al. Rheumatol Int. 2017;37:257–71

*Based on a study conducted in the United States.

Onset and diagnosisAffects young people: mean age of symptom onset

8.5 years to diagnosis6

= in mid-20s.5 Average delay of

axSpA is a chronic inflammatory disease, predominantly involving the spine and sacroiliac joints.1–4

Uveitis (eye inflammation)

Osteoporosis andvertebral fractures (bone weakening and breakage or collapse of bones in the spine)

Northern Arctic indigenous communities 0.35

Sub-Saharan Africa 0.02

Europe 0.25North America 0.20East Asia 0.16

South America 0.14North Africa/Middle East 0.11

South-East Asia 0.07South Asia 0.06

HQ/0417/CI/00039; Date of preparation: May 2017

spine

sacroiliac joint

Disease spectrum2–4

Non-radiographic axSpAno definite sacroiliitis on X-ray; may have magnetic resonance imaging evidence of inflammation of sacroiliac joint

Ankylosing spondylitis (AS)definite sacroiliitis on X-ray

axSpA

~10–12% develop definite radiographic

sacroiliitis over 2 years

(without structural damage) (with structural damage)

Symptoms2,11–13

DISTURBED SLEEPbecause of back pain usually during the second half of the night

REDUCED MOBILITY

STIFFNESS

FATIGUE

INFLAMMATORY BACK PAIN(leading symptom)that improves with exercise, but not with rest(in contrast to mechanical back pain)

Enthesitis (inflammation of the points of insertion of tendons and ligaments into bone; especially enthesitis of the heel)

Psoriasis (skin disease)

Inflammatory bowel disease(chronic inflammation of digestive tract)

Peripheral arthritis(usually involving large joints)