Automated Sample Preparation ModulesBetter sample prep for better LC-MS data

Strategies for automating sample preparation

Offline sample preparation:

■■ Sample prep and LC-MS

in separate platforms

■■ Sample prep and LC-MS

conducted independently

■■ One or both operations

is automated

■■ Manual intervention

required

■■ Instrumentation:

MassTrak OASPS

Online sample preparation:

■■ Sample prep and LC-MS

in a single platform

■■ Sample prep directly

integrated with LC-MS

■■ Both operations are

fully automated

■■ Instrumentation:

ACQUITY UPLC OSM

AUTOMAT E AND INT EGRAT E YOUR LC-MS SAMPLE P REPARAT ION

Historically, preparing samples for LC-MS has required a great deal of time and effort as

well as extensive expertise to perform well. Deployment of many sample prep techniques

has been hampered by their highly complex, labor intensive, and costly workflows.

However, many of these issues can be addressed through automation and direct integration

with LC-MS analysis.

Waters has applied its decades of experience in developing sample preparation solutions

and methods for LC-MS with the MassTrak™ Offline Automated Sample Preparation

System (OASPS) and the ACQUITY UPLC® Online SPE Manager (OSM). These modules

utilize powerful solid phase extraction (SPE) chemistries and techniques to efficiently

and effectively prepare samples for LC-MS from a variety of sample matrices.

Ideal for virtually any laboratory using LC-MS ranging from the novice user looking to

efficiently deploy LC-MS with minimal expertise to the LC-MS expert looking to maximize

throughput, up time and utilization of their LC-MS systems, Waters’ automated sample

preparation products offer the most extensive range of choices in sample preparation.

ACQUITY UPLC Online SPE Manager.

MassTrak Offline Automated Sample Prep System.

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Enhance laboratory productivity■■ Minimal manual intervention

for sample prep

■■ Automates SPE procedure

using proven µElution plates

■■ Direct software linkage

with LC-MS

Comprehensive sample data tracking and LC-MS interface■■ Complete sample tracking

from sample tube to

SPE plate to LC-MS

■■ Automatic sample data

transfer to the LC-MS system

Robust and easy to use■■ Simple, SPE dedicated, small

footprint automation system

■■ Equipped with pre-written

pipetting script for SPE

■■ Compatible with

ACQUITY UPLC and

ACQUITY UPLC I-Class

Systems, and the

ACQUITY TQD, Xevo® TQD,

Xevo TQ MS, Xevo TQ-S

mass spectrometers

A COMP REHENSIV E, EASY-ACC ESS AUTOMATION PACKAGE

The MassTrak OASPS is a single vendor supported, hardware and software inclusive

sample preparation system for LC-MS. The system features all the power of an automated

liquid handling system with less complexity or operating expertise required compared

to typical standalone robotic systems.

This highly flexible system for SPE procedures includes all the automation capabilities

(liquid pipetting, tube to plate liquid transfer, plate manipulation, barcode scanning,

vacuum manifold, and plate shaking) required to perform SPE on samples from either

simple or complex matrices with a minimum of manual intervention.

Its unique software package includes a pre-written SPE pipetting script and file converter

software to facilitate quick and effective deployment of the system with a minimum of

expertise. In addition to automating sample processing to improve consistency, this

system makes sample data transfers seamless to minimize sample processing and data

transfer errors all too common with manual sample preparation.

MassTrak OASPS with ACQUITY UPLC and ACQUITY® TQD.

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Optimizes LC-MS workflow productivity■■ Full automation of all SPE

and LC-MS operations

■■ Unique direct integration

of sample prep with LC-MS

■■ Complete walk away system

■■ Overlapping Sample Prep

and LC-MS processes improve

sample throughput

Delivers superior data consistency■■ Utilizes a variety of market

tested SPE sorbents

■■ Eliminates sample carry over

and unpredictable matrix

effects with disposable

SPE cartridges

■■ Integrates with a new or

existing ACQUITY TQD

LC-MS System

Accelerates sample prep method development■■ Control of all SPE

experimental variables

■■ Tests multiple variables

simultaneously to quickly

develop SPE methods

■■ Operates with ACQUITY UPLC

Systems controlled with

intuitive MassLynx®

4.1 Software.

T HE ULT IMAT E IN LC-MS SAMPLE P REP P RODUCT IV IT Y

The ACQUITY UPLC Online SPE Manager (OSM) is a unique automated sample preparation

module designed either for routine operations and/or as an SPE method development tool.

The system is an easily integrated module for UPLC®-based systems that offers a more

efficient workflow for than slower and older, less consistent column based online SPE

systems. An excellent choice for almost any laboratory performing LC-MS analyses,

the ACQUITY UPLC OSM is the pinnacle of automation and integration of sample prep

with LC-MS.

The ACQUITY UPLC OSM’s unique design resolves many of the direct resource utilization

and method expertise issues that have prevented many laboratories from including

effective sample prep techniques in their LC-MS analysis workflows. Truly a walk away

system, it can transform LC-MS analysis into an around the clock operation to allow users

to get the most performance and productivity from their LC-MS systems.

Applicable to a wide variety of LC-MS applications, the ACQUITY UPLC OSM is excellent

at everything from providing laboratories with the capability to develop methods for low

level analytes to helping optimize current LC-MS methods to improve reproducibility,

sensitivity, and efficiency. Capable of generating very clean samples from even very

complex matrices, the ACQUITY UPLC OSM can also help keep LC-MS systems in operation

longer and improve system up time by delivering much cleaner samples for LC-MS

analysis than other sample preparation techniques.

The ACQUITY UPLC OSM is the key component in the pre-configured MassTrak Online SPE

Analyzer. This system combines the power of the ACQUITY UPLC System, ACQUITY TQD,

and intuitive MassLynx Software with the online sample preparation benefits delivered

with the ACQUITY UPLC OSM module in a single, seamless platform. With this system

configuration, many routine LC-MS applications can be addressed with a highly efficient,

integrated LC-MS system.

MassTrak Online SPE Analyzer includes ACQUITY UPLC, ACQUITY UPLC OSM, and ACQUITY TQD.

Waters Corporation 34 Maple Street Milford, MA 01757 U.S.A. T: 1 508 478 2000 F: 1 508 872 1990 www.waters.com

Waters, ACQUITY, ACQUITY UPLC, MassLynx, Xevo, UPLC and The Science of What’s Possible are registered trademarks of Waters Corporation. MassTrak is a trademark of Waters Corporation. All other trademarks are the property of their respective owners.

©2014 Waters Corporation. Printed in the U.S.A. July 2014 720005058EN TC-SIG

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