atypical antipsychotics: comparable efficacy in bipolar disorder

Inpharma 1260 - 21 Oct 2000 Atypical antipsychotics: comparable efficacy in bipolar disorder Clozapine, risperidone and olanzapine appear to demonstrate equivalent efficacy and tolerability in the treatment of patients with bipolar disorder, say researchers from the US. Using data from the US Massachusetts General Hospital Bipolar Clinic database, the researchers retrospectively analysed data from 50 consecutive treatment trials involving a total of 42 patients with bipolar disorder type I, who had received ≥ 1 dose of clozapine, risperidone or olanzapine in addition to standard mood stabilisers. Similar efficacy During the treatment trials, 34 (68%) of the Clinical Global Impressions (CGI) ratings improved by ≥ 1 point. CGI scores demonstrated similar and significant improvements from baseline to last visit in all treatment groups. Extrapyramidal symptoms were reported by 12/42 patients (28.6%) at any follow-up visit. Parkinsonism was observed in 4 of 25 risperidone recipients, 1 of 20 olanzapine recipients and 1 of 5 clozapine recipients. Corresponding numbers of patients who experienced akathisia were 2, 3 and 1, respectively. Smaller bodyweight gain with risperidone During treatment, mean overall bodyweight gain was greater with olanzapine and clozapine, compared with risperidone, administration. A bodyweight gain of ≥ 4.5kg was seen in 12/19 olanzapine recipients (63%), compared with 8/24 risperidone recipients (33%). The researchers note that ‘since patients with bipolar disorder require mood stabilizers that often produce weight gain, the addition of novel antipsychotics with this side effect can exacerbate this problem’. Guille C, et al. A naturalistic comparison of clozapine, risperidone, and olanzapine in the treatment of bipolar disorder. Journal of Clinical Psychiatry 61: 638-642, Sep 2000 800848163 1 Inpharma 21 Oct 2000 No. 1260 1173-8324/10/1260-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved

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Inpharma 1260 - 21 Oct 2000

Atypical antipsychotics:comparable efficacy in bipolar

disorderClozapine, risperidone and olanzapine appear to

demonstrate equivalent efficacy and tolerability in thetreatment of patients with bipolar disorder, sayresearchers from the US.

Using data from the US Massachusetts GeneralHospital Bipolar Clinic database, the researchersretrospectively analysed data from 50 consecutivetreatment trials involving a total of 42 patients withbipolar disorder type I, who had received ≥ 1 dose ofclozapine, risperidone or olanzapine in addition tostandard mood stabilisers.

Similar efficacyDuring the treatment trials, 34 (68%) of the Clinical

Global Impressions (CGI) ratings improved by ≥ 1 point.CGI scores demonstrated similar and significantimprovements from baseline to last visit in all treatmentgroups.

Extrapyramidal symptoms were reported by 12/42patients (28.6%) at any follow-up visit. Parkinsonismwas observed in 4 of 25 risperidone recipients, 1 of 20olanzapine recipients and 1 of 5 clozapine recipients.Corresponding numbers of patients who experiencedakathisia were 2, 3 and 1, respectively.

Smaller bodyweight gain with risperidoneDuring treatment, mean overall bodyweight gain was

greater with olanzapine and clozapine, compared withrisperidone, administration. A bodyweight gain of ≥4.5kg was seen in 12/19 olanzapine recipients (63%),compared with 8/24 risperidone recipients (33%). Theresearchers note that ‘since patients with bipolardisorder require mood stabilizers that often produceweight gain, the addition of novel antipsychotics with thisside effect can exacerbate this problem’.Guille C, et al. A naturalistic comparison of clozapine, risperidone, and olanzapinein the treatment of bipolar disorder. Journal of Clinical Psychiatry 61: 638-642,Sep 2000 800848163

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