atenolol and nifedipine provide relief in ambulant myocardial ischaemia

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10 Atenolol and nifedipine provide relief in ambulant myocardial ischaemia The number and average duration of episodes of ambulatory ischaemia, were significantly reduced by both atenolol and nifedipine monotherapy compared with baseline, in patients with coronary artery disease and evidence of minimally symptomatic ambulatory myocardial ischaemia. Nifedipine also significantly reduced the total duration of ischaemic episodes. ' ••• Either IItenolol or nifedipine ltUIy be effecti,e therllPY compared with plllCebo, but neither is necessarily superior and ischaemia may actually increase with either therapy . .. Combination therapy may prove useful' when monotherapy is ineffective. Following a 2-week placebo run-in period, patients randomly received atenolol 50-100 mg/day (n = 8) or nifedipine 10-20mg (10) tid for 2 weeks each in a crossover fashion, with a 2- week placebo period between treatments. Combination therapy was administered for 2 weeks to those with persistent asymptomatic ischaemia. Eight patients had complete relief from ambulant ischaemia with monotherapy. and 4 nifedipine and 3 atenolol recipients experienced an increase in ischaemia with drug therapy. Of the 9 evaluable patients who received combination therapy. 2 had no ischaemic episodes. 5 had a reduction of 50% in the number of ischaemic episodes. I had a reduction of < 50% and I had no change. Hill JA. Gonzalez JI. Kolb R. Pepine CJ. Effects of atcnolol alone. nifedipine alone and their combination on ambulant myocardial ischaemia. American Journal of Cardiology 67: 671-675. 1 Apr 1991 "50 - 10 Apr 1991 INPHARMA- ISSN 0156-1703/91/0410-0010/0S01.00/0 C Atlill.tel'lUltiolUll Ltd

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Page 1: Atenolol and nifedipine provide relief in ambulant myocardial ischaemia

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Atenolol and nifedipine provide relief in ambulant myocardial ischaemia

The number and average duration of episodes of ambulatory ischaemia, were significantly reduced by both atenolol and nifedipine monotherapy compared with baseline, in patients with coronary artery disease and evidence of minimally symptomatic ambulatory myocardial ischaemia. Nifedipine also significantly reduced the total duration of ischaemic episodes. ' ••• Either IItenolol or nifedipine ltUIy be effecti,e therllPY compared with plllCebo, but neither is necessarily superior and ischaemia may actually increase with either therapy . .. Combination therapy may prove useful' when monotherapy is ineffective.

Following a 2-week placebo run-in period, patients randomly received atenolol 50-100 mg/day (n = 8) or nifedipine 10-20mg (10) tid for 2 weeks each in a crossover fashion, with a 2-week placebo period between treatments. Combination therapy was administered for 2 weeks to those with persistent asymptomatic ischaemia. Eight patients had complete relief from ambulant ischaemia with monotherapy. and 4 nifedipine and 3 atenolol recipients experienced an increase in ischaemia with drug therapy. Of the 9 evaluable patients who received combination therapy. 2 had no ischaemic episodes. 5 had a reduction of 50% in the number of ischaemic episodes. I had a reduction of < 50% and I had no change. Hill JA. Gonzalez JI. Kolb R. Pepine CJ. Effects of atcnolol alone. nifedipine alone and their combination on ambulant myocardial ischaemia. American Journal of Cardiology 67: 671-675. 1 Apr 1991 "50

- 10 Apr 1991 INPHARMA- ISSN 0156-1703/91/0410-0010/0S01.00/0 C Atlill.tel'lUltiolUll Ltd