antihypertensive therapy cost effective in older age groups

PharmacoEconomics & Outcomes News 26 - 8 Apr 1995 Antihypertensive therapy cost effective in older age groups It is generally cost effective to treat hypertension in men and women aged > 45 years who have a pretreatment diastolic BP of ≥ 90mm Hg, says Magnus Johannesson. However, it is not cost effective to treat younger patients with mild hypertension (diastolic BP ≤ 104mm Hg), he adds. Mr Johannesson, from the Stockholm School of Economics in Sweden, conducted a cost-effectiveness analysis of antihypertensive therapy in different patient groups in that country. He used a computer simulation model that was based on risk functions for coronary heart disease and stroke from the Framingham heart study. Results of the most recent meta-analysis of antihypertensive treatment were used to determine the risk reduction associated with therapy – the values were 16% and 38% for coronary heart disease and stroke, respectively. The annual cost of treating hypertension in Sweden was estimated at around SEK3000/patient. Interestingly, the cost/life-year gained of antihypertensive therapy decreased with increasing age and pretreatment diastolic BP for both men and women [see table]. The difference in cost effectiveness between the youngest group and the other 2 age groups was large, according to Mr Johannesson. He points out that in most analyses, interventions with cost-effectiveness ratios < SEK100 000/life-year gained are considered highly cost effective. Table. Cost/life-year gained of anti-hyper-tensive therapy in Sweden* Pretreat-ment dias-tolic Age (years) BP (mm Hg) < 45 45–69 ≥ 70 Men Women Men Women Men Women 90–94 947 2506 68 215 25 21 95–99 780 1894 34 133 14 7 100–104 636 1388 1 59 3 Cost saving ≥ 105 440 746 Cost Cost Cost Cost saving saving saving saving * SEK thou-sands; 1992 values Johannesson M. The cost effectiveness of hypertension treatment in Sweden. PharmacoEconomics 7: 242-250, Mar 1995 800345237 1 PharmacoEconomics & Outcomes News 8 Apr 1995 No. 26 1173-5503/10/0026-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved

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PharmacoEconomics & Outcomes News 26 - 8 Apr 1995

Antihypertensive therapy costeffective in older age groups

It is generally cost effective to treat hypertension inmen and women aged > 45 years who have apretreatment diastolic BP of ≥ 90mm Hg, says MagnusJohannesson. However, it is not cost effective to treatyounger patients with mild hypertension (diastolic BP ≤104mm Hg), he adds.

Mr Johannesson, from the Stockholm School ofEconomics in Sweden, conducted a cost-effectivenessanalysis of antihypertensive therapy in different patientgroups in that country. He used a computer simulationmodel that was based on risk functions for coronaryheart disease and stroke from the Framingham heartstudy. Results of the most recent meta-analysis ofantihypertensive treatment were used to determine therisk reduction associated with therapy – the values were16% and 38% for coronary heart disease and stroke,respectively. The annual cost of treating hypertension inSweden was estimated at around SEK3000/patient.

Interestingly, the cost/life-year gained ofantihypertensive therapy decreased with increasing ageand pretreatment diastolic BP for both men and women[see table]. The difference in cost effectiveness betweenthe youngest group and the other 2 age groups waslarge, according to Mr Johannesson. He points out thatin most analyses, interventions with cost-effectivenessratios < SEK100 000/life-year gained are consideredhighly cost effective.

Table. Cost/life-year gained of anti-hyper-tensivetherapy in Sweden*

Pretreat-ment dias-tolic Age (years)BP (mm Hg)

< 45 45–69 ≥ 70

Men Women Men Women Men Women90–94 947 2506 68 215 25 2195–99 780 1894 34 133 14 7100–104 636 1388 1 59 3 Cost

saving≥ 105 440 746 Cost Cost Cost Cost

saving saving saving saving

* SEK thou-sands; 1992 values

Johannesson M. The cost effectiveness of hypertension treatment in Sweden.PharmacoEconomics 7: 242-250, Mar 1995 800345237

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