antibody-drug conjugates (adcs): purposefully designed to ... · antibody-drug conjugates (adcs):...
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Antibody-Drug Conjugates (ADCs):Purposefully Designed to Link Technology with Biology
Pfizer Oncology is investing in research to develop a broad ADC platform from a diverse toolkit of antibodies, linkers and cytotoxins. Each
component is precisely selected based on our deep understanding of biological characteristics of the target tumor.
Click Here to Learn How ADCs Work
How ADCs WorkADCs are designed to precisely deliver cytotoxins to cancer cells with potential to
treat both solid tumors and hematologic cancers.
Click on each picture to see how.
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How ADCs WorkADCs are designed to precisely deliver cytotoxins to cancer cells with potential to
treat both solid tumors and hematologic cancers.
Click on each picture to see how.
Antibody
Cytotoxin Linker
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ADCs use a chemical linker to connect cytotoxins – such as
chemotherapy – with an antibody.
How ADCs WorkADCs are designed to precisely deliver cytotoxins to cancer cells with potential to
treat both solid tumors and hematologic cancers.
Click on each picture to see how.
Antigen
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This enables the ADC to target and bind to cell-surface proteins called
antigens found preferentially on cancer cells…
Antibody
Cytotoxin Linker
ADCs use a chemical linker to connect cytotoxins – such as
chemotherapy – with an antibody.
How ADCs WorkADCs are designed to precisely deliver cytotoxins to cancer cells with potential to
treat both solid tumors and hematologic cancers.
Click on each picture to see how.
Restart
…and time the release of its cell-killing drugs only after it has been internalized inside the cancer cell.
Antibody
Cytotoxin Linker
Antigen
This enables the ADC to target and bind to cell-surface proteins called
antigens found preferentially on cancer cells…
ADCs use a chemical linker to connect cytotoxins – such as
chemotherapy – with an antibody.
As a result, ADCs have the potential to selectively kill cancer cells and minimize side-effects for
patients.
How ADCs WorkADCs are designed to precisely deliver cytotoxins to cancer cells with potential to
treat both solid tumors and hematologic cancers.
Click on each picture to see how.
Restart
Antibody
Cytotoxin Linker
Antigen
…and time the release of its cell-killing drugs only after it has been internalized inside the cancer cell.
This enables the ADC to target and bind to cell-surface proteins called
antigens found preferentially on cancer cells…
ADCs use a chemical linker to connect cytotoxins – such as
chemotherapy – with an antibody.