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Address Oncology Graduate School Amsterdam OOA VU medisch centrum Kamer PK 7Z 182 De Boelelaan 1117 1081 HV Amsterdam phone : 020-4443113 e-mail : [email protected] website : www.ooa-graduateschool.org

Contents Preface

1 Board and organization 09

2 General report 13

3 Educational activities 19

4 PhD research program 25

5 Awards 45 Annex 1 Faculty and staff 49 Annex 2 International visitors 61 Annex 3 PhD theses completed 65 Annex 4 Scientific publications 73

Oncology Graduate School Amsterdam OOA

preface

Preface - 7

Preface An important mission of the Oncology Graduate School Amsterdam (Onderzoekschool Oncologie Amsterdam – OOA) is to organize the education in basic and clinical cancer research of the graduate students in the Amsterdam region, and to ensure proper supervision and mentoring of graduate students. The OOA graduate students are scientist-in-training who receive additional theoretical and practical education on various subjects related to cancer. OOA is a joint venture of the medical faculties the VU University Medical Center (VUmc) and the Academic Medical Center (AMC), of the VU University Amsterdam (Vrije Universiteit - VU) and the University of Amsterdam (Universiteit van Amsterdam- UvA), respectively, and the Netherlands Cancer Institute (Nederlands Kanker Instituut - NKI). These organizations strive for excellence in research and education in oncology, the realization of which is promoted by their participation in OOA. The OOA research program ranges from basic molecular biology to clinical bedside research. It includes, for instance, fundamental studies on cellular signal transduction and the control of gene expression, but also clinical trials of new (combination) approaches and the development of new tools to evaluate the quality of life in cancer patients. OOA organizes a range of educational

activities, including specialized training courses, seminars and meet-the-expert sessions. Besides this, major effort is put into the organization of an annual graduate student retreat. This retreat teaches skills in reporting, presenting and collaboration activities. This report presents the activities and scientific output of OOA in 2012. It includes detailed listings of our educational activities, such as training programs, and an overview of the scientific output, including listings of PhD theses completed and scientific papers published throughout 2012. Executive Directors, Prof. dr. A.W. Griffioen (VUMC) Prof. dr. T.K. Sixma (NKI) Dr. M. Spaargaren (UvA)

8 - Preface


board and organization

Board and organization - 11

1. Board and organization Board Prof.dr. A. Berns, chairman Prof.dr. S. Rodenhuis Prof.dr. C.J.L.M. Meijer Prof.dr. P. Postmus Prof.dr. C.E.E. Konings Prof.dr. D.J. Richel Executive directors Prof. dr. A.W. Griffioen, chairman Prof. dr. T.K. Sixma Dr. M. Spaargaren

Participating institutes VU University Amsterdam (VU)/ VU University Medical Center (VUmc) Administrative center Contact / secretariat: dr. E.M. Ruhé-Hoogervorst De Boelelaan 1117 1081 HV Amsterdam phone : 020-4443113 fax : 020-4442964 email : [email protected] University of Amsterdam (UvA)/ Academic Medical Center (AMC) Meibergdreef 15 1105 AZ Amsterdam phone : 020-5668502 fax : 020-5669165 Netherlands Cancer Institute (NKI) Contact / secretariat: Ms. P. Lagerweij Plesmanlaan 121 1066 CX Amsterdam phone : 020-512 6973 fax : 020-512 1944 email : [email protected] Faculty and staff The complete list of founding institutes’ faculty and staff involved in educational activities and research projects conducted by OOA is provided in Annex 1.

12 – Board and organization


general report

General report - 15

2. General report

Educational activities The OOA is a successful and large graduate school, with 440 PhD students, 124 faculty and 409 OOA staff members involved. Among the Dutch graduate research schools, OOA is one of the 10 schools within the field of ‘Medicine’. It is the only school specifically focusing on training in cancer research. Monitoring of the quality of research in the different institutes is performed by local committees at the participating institutes, e.g. a research institute or board. The quality of the OOA is shown by its regular accreditation by the Royal Netherlands Academy of Sciences regularly, currently for the period 2009-2014. The core activity of OOA is training PhD students in conducting cancer research. For this purpose, OOA has developed a high-quality curriculum. In 2012, OOA organized various graduate training courses and an Annual Graduate Student Retreat. All courses were evaluated by means of standardized evaluation procedures. In this way, OOA carefully monitors the quality of its courses. Based on the outcome of these evaluations, the training programs are being improved continuously. A detailed description of all training courses offered in 2012 is provided in chapter 3 of this Annual Report. Research program Research projects at OOA’s institutes can be clustered under two main themes. The theme 'Experimental biology' covers 'Oncogenesis' and 'Tumor cell biology' as the main lines of research. The second main theme is 'Experimental clinical research' and covers 'Diagnosis of cancer' and 'Prevention and therapy of cancer'. Chapter 4 provides listings of all individual PhD projects conducted within these main themes. More detailed descriptions of these research programs and their output are provided in the annual reports of the founding institutes. Theme 1: Experimental biology The transformation of a normal cell into a malignant tumor cell requires multiple (epi)genetic alterations affecting genes that control cellular pathways. Studying the genes and proteins involved in these pathways results in better understanding of tumor development, progression

and therapy resistance. Candidate markers are tested for their ability to predict/detect cancer at an early stage. Disease profiling is being improved using innovative research tools. Tools applied in research projects include high-throughput methods for (epi)genetic, transcriptomic and proteomic analyses. Examples are large tumor cohort screens with CGH or expression arrays, gain-of-function genetic screens with retroviral cDNA expression libraries, and loss-of-function genetic screens with RNA interference libraries. Quantitative mass spectrometry is being used to search for proteins to distinguish the diseased and disease-free states. Mechanistic studies using e.g. structural biology complement the functional studies. Advanced mouse models or sophisticated xenotransplant models have been developed for the genetic dissection of cancer. At cellular level, processes like cell-cell communication, adhesion, migration, survival, proliferation and differentiation are all being studied. Furthermore, the mechanisms of therapy resistance and metastasis are being investigated. Viral oncogenesis projects focus on the role of human papilloma viruses and Epstein-Barr virus in the development of human cancer, by using both in vitro models and clinically well-defined patient tumor samples. Viral and host markers are being tested for their capability to assess the risk associated with the development of cancer. Theme 2: Experimental clinical research Improvements in clinical care in oncology are based on improved detection, development of innovative therapies and personalized treatment strategies. The emerging and rapidly growing fields of molecular imaging and genomics are providing new opportunities to study the biology of a malignancy in individual patients and thus allowing for the development of highly valuable indicators for diagnosis and prediction of disease outcome. The development of the 70-gene breast cancer predictor at the NKI has led to the first FDA-approved diagnostic screen for breast cancer. Modern state-of-the-art techniques like MRI, SPECT, PET and PET/CT are enabling imaging methods with high precision and unique molecular and biological information at the tissue level. (Molecular) reporter probes are being developed and evaluated. Highly developed mouse models are being used to follow drug sensitivity in several types of cancer and for developing clinical strategies for imaging. Targeted cancer therapy is yet another research focus. Personalized therapy should ensure optimal treatment benefits. Projects include (pre)clinical evaluations of the use of

16 – General report

neoadjuvant treatment or the application of new molecular therapies and anti-angiogenic agents against novel targets in tumor and its environment. The pharmacological optimization of conventional cytotoxic drugs is an important line of research, as is the passage of drugs through the blood-brain barrier. Development of immunotherapies based on adoptive transfer and vaccination strategies are at the forefront of research. These, as well as novel targeted (anti-angiogenic) therapies and gene therapy strategies are being developed and tested in clinical trials. Another important clinical research theme is quality of life for childhood and adult patients with cancer. PhD projects and students Overall, 440 PhD projects were actively elaborated throughout 2012. The names of the PhD students at the three OOA institutes and the projects in which they participated are listed in chapter 4. Of all PhD projects, 19% was funded by the participating institutes themselves (primary funding; ‘eerste geldstroom'); 15% was financed by public funds (secondary funding; 'tweede geldstroom'), 42% by research contracts from external organisations including cancer charity and industrial funds (tertiary funding; ‘derde geldstroom’) and 24% was financed by other funds (quaternary funding; 'vierde geldstroom'). A total of 72 PhD students completed and defended their PhD thesis in 2012. Annex 3 provides the complete list of PhD students who obtained their degree in 2012 with details of their theses and graduation. International visitors Training of PhD students can be stimulated and enhanced by having scientific interactions between students and foreign experts operating in the field of the students’ research projects. OOA is part of a large international network of cancer researchers and, therefore, international guests from other research institutes visit OOA’s institutes frequently to interact with OOA students and staff. Throughout 2012, we welcomed 55 international experts in various settings (Annex 2). Awards Several PhD students and staff of the OOA institutes won prestigious awards and honors – scientific or otherwise – in 2012. Chapter 5 provides a listing of these awards and honours. OOA has an excellent (inter)national status, as demonstrated by the large number of research projects granted in open national and international calls, including several of the prestigious new grants. The faculty is strongly represented in the

‘vernieuwingsimpuls’, the Veni-Vidi-Vici development grants for junior researchers and participates widely in CTMM projects and TI Pharma projects as well as in numerous EU integrated projects and networks of excellence. Funding is also strongly supported by the Dutch science foundation NWO and the cancer society, KWF. Research highlights Research highlights included work of M.A. Cuesta et al. Surgical resection is regarded as the only curative option for resectable oesophageal cancer, but pulmonary complications occurring in more than half of patients after open oesophagectomy are a great concern. They assessed whether minimally invasive oesophagectomy reduces morbidity compared with open oesophagectomy. Their findings provided evidence for the short-term benefits of minimally invasive oesophagectomy for patients with resectable oesophageal cancer (Lancet 379(9829):1887-92). Ubiquitin-dependent signaling during the DNA damage response (DDR) to double-strand breaks (DSBs) is initiated by two E3 ligases, RNF8 and RNF168, targeting histone H2A and H2AX. RNF8 is the first ligase recruited to the damage site, and RNF168 follows RNF8-dependent ubiquitination. This suggests that RNF8 initiates H2A/H2AX ubiquitination with K63-linked ubiquitin chains and RNF168 extends them. Here, we show that RNF8 is inactive toward nucleosomal H2A, whereas RNF168 catalyzes the monoubiquitination of the histones specifically on K13-15. Structure-based mutagenesis of RNF8 and RNF168 RING domains shows that a charged residue determines whether nucleosomal proteins are recognized. We find that K63 ubiquitin chains are conjugated to RNF168-dependent H2A/H2AX monoubiquitination at K13-15 and not on K118-119. Using a mutant of RNF168 unable to target histones but still catalyzing ubiquitin chains at DSBs, F. Mattiroli showed that ubiquitin chains per se are insufficient for signaling, but RNF168 target ubiquitination is required for DDR (F. Mattiroli et al. Cell 150(6):1182-95). Neuroblastoma is a childhood tumour of the peripheral sympathetic nervous system. The pathogenesis has for a long time been quite enigmatic, as only very few gene defects were identified in this often lethal tumour. Frequently detected gene alterations are limited to MYCN amplification (20%) and ALK activations (7%). A whole-genome sequence analysis of 87 neuroblastoma of all stages performed by J.J. Molenaar et al. revealed two novel molecular defects, chromothripsis and neuritogenesis gene alterations, which frequently occur in high-risk tumours (Nature 483(7391):589-93). LIN28B regulates developmental processes by modulating microRNAs (miRNAs) of the let-7 family. A role for LIN28B in cancer has been proposed but has not been established in vivo. J.J. Molenaar et al report that LIN28B showed genomic

General report - 17

aberrations and extensive overexpression in high-risk neuroblastoma compared to several other tumor entities and normal tissues. High LIN28B expression was an independent risk factor for adverse outcome in neuroblastoma. LIN28B signaled through repression of the let-7 miRNAs and consequently resulted in elevated MYCN protein expression in neuroblastoma cells. LIN28B-let-7-MYCN signaling blocked differentiation of normal neuroblasts and neuroblastoma cells. These findings were fully recapitulated in a mouse model in which LIN28B expression in the sympathetic adrenergic lineage induced development of neuroblastomas marked by low let-7 miRNA levels and high MYCN protein expression. Interference with this pathway might offer therapeutic perspectives (Nature genetics 44(11):1199-206). Data generated by A. Prahallad et all suggest that BRAF(V600E) mutant colon cancers (approximately 8-10% of all colon cancers), for which there are currently no targeted treatment options available, might benefit from combination therapy consisting of BRAF and EGFR inhibitors (Nature 483(7387):100-103). Screening for colorectal cancer is widely recommended, but the preferred strategy remains unidentified. E.M. Stoop et al. compared participation and diagnostic yield between screening with colonoscopy and with non-cathartic CT colonography. They showed that participation in colorectal cancer screening with CT colonography was significantly better than with colonoscopy, but colonoscopy identified significantly more advanced neoplasia per 100 participants than did CT colonography. The diagnostic yield for advanced neoplasia per 100 invitees was similar for both strategies, indicating that both techniques can be used for population-based screening for colorectal cancer. Other factors such as cost-effectiveness and perceived burden should be taken into account when deciding which technique is preferable (Lancet Oncology 13(1):55-64. Stereotactic ablative radiotherapy (SABR) is increasingly used in the treatment of medically inoperable early stage non-small-cell lung cancer (NSCLC). Because patterns of late disease recurrence after SABR are not well characterised, S. Senthi et al. aimed to assess these outcomes in a cohort of patients with NSCLC. Late recurrences after SABR are infrequent and two distinct patterns account for most cases. The predominant pattern is out-of-field, isolated distant recurrence presenting early, despite initial PET staging. A third of patients develop isolated locoregional recurrence; for these patients standardised follow-up is important to ensure that appropriate salvage treatments are considered (Lancet Oncology 13: 802-809). Current strategies combining anti-angiogenic drugs with chemotherapy provide clinical benefit in cancer patients. It is assumed that anti-angiogenic drugs, such as bevacizumab, transiently normalize abnormal tumor vasculature and contribute to improved delivery of subsequent chemotherapy. To investigate this concept, a study was performed by

A.A. van der Veldt et al. in non-small cell lung cancer (NSCLC) patients using positron emission tomography (PET) and radiolabeled docetaxel ([(11)C]docetaxel). In NSCLC, bevacizumab reduced both perfusion and net influx rate of [(11)C]docetaxel within 5 hr. These effects persisted after 4 days. The clinical relevance of these findings is notable, as there was no evidence for a substantial improvement in drug delivery to tumors. These findings highlight the importance of drug scheduling and advocate further studies to optimize scheduling of anti-angiogenic drugs (Cancer Cell 21: 82-91). A total of 2023 papers have been published by researchers from the three institutes. Of these, 144 papers concerned collaborations between researchers from VUmc, NKI and AMC. Annex 4 provides the complete list of scientific publications in 2012. Facilities The main goal of all research activities of the 3 OOA institutes is to better understand the development of cancer and to improve the perspectives of cancer patients. For this purpose, many state-of-the-art technologies are present and new initiatives have been developed. Information about innovative technologies is communicated at many occasions, including courses and the OOA retreat, and these technologies are open to PhD students within OOA. As a result, the OOA PhD students often have early access to novel techniques and can apply these in research. State-of-the-art facilities are: * Deep sequencing facility (NKI, AMC) * Microarray facilities with high resolution oligonucleotide array and CGH arrays for mouse and human studies (VUmc, NKI, UvA) * Oncoproteomics laboratory for protein and glycan profiling using mass spectrometry (VUmc, AMC) * (Molecular) Imaging facilities (cyclotrons, GMP facilities, animal and clinical PET/CT-cameras and MRI-machines) enabling imaging of anatomical details with high precision (VUmc) * Tissue microarray facility (VUmc, AMC) * Robotics and screening facility, including high content imaging (NKI) * Microscopy facility, including extensive confocal and electron microscopy (NKI, AMC) * (Flow) cytometry facilities - Coulter, BD, Acumen (NKI, AMC, VUmc) * Extensive animal facilities (NKI, AMC) * Imaging facilities, microPET, MRI, SPECT (VUMC, NKI, AMC) * Radiotherapy facilities (NKI, VUMC) * Tissue and Serum biobanks (NKI, VUmc) * Genomics: MPS GS-FLEX sequencer (AMC) * Lentiviral library for RNA-silencing for human and mouse (AMC) * Mass spectrometry facility (NKI, VUmc, AMC) * Protein expression and biophysical characterization facility (NKI)

18 – General report

In addition, new initiatives are: * Imaging Center (including training center) (VUmc) * Central Clinical Trial Support (office) (VUmc, AMC) * Phase I/II unit for clinical trials (VUmc, AMC) * Biobanking (VUmc, AMC) * Human monoclonal antibody phage display facility (VUmc) * Mouse Clinic (NKI)


educational activities

Educational activities - 21

3. Educational activities In line with its mission, i.e. providing graduate students education in oncology research, OOA organizes several advanced courses in the field of oncology annually. The educational program is drawn up by the Board of Directors based upon evaluations of previous courses, contemporary developments in cancer research, and educational needs expressed by PhD students as well as initiatives from the OOA faculty. OOA offers courses focused on a wide variety of topics. In 2012, 7 courses and 2 Meet-the-Expert sessions were organized. In addition, the Annual Graduate Student Retreat was organized again in 2012. Courses are usually restricted to about 15-20 graduate students to ensure optimal interaction between students and faculty. Courses are advertised on the OOA website and announced by e-mail to the PhD students. Courses included lectures given by (inter)national experts, demonstrations and practical training. Besides the specialized oncological courses mentioned below, the graduate students followed several general courses such as on biostatistics and epidemiology, on laboratory animal technology and on writing and (poster)presentations techniques in scientific English. These courses were organized by the AMC, VUmc and NKI. How to write High Impact papers and what to do when it is rejected Organization: dr. M. van der Linden Date: 26 and 13 March Location: VUmc Scientific writing is undergoing dramatic changes. Many papers are rejected without being sent for peer review and yet other papers appear on PubMed within weeks of submission. This workshop will introduce strategies for writing journal articles so that the process may not be effortless and joyous, but at least less painful and more assured of success. Topics include creative means of using electronic resources, cultivating collaborations, building writing into your life style, writing and rewriting the manuscript, getting your manuscript past the editor and sent out for peer review, postsubmission responsibilities, and using publicity to increase early citations. A total number of 46 PhD students participated in the course (2 classes). The overall evaluation rate was 4.1 (scale 1-5).

The Microscopic, Macroscopic and Pathologic Anatomy of the Mouse Organization: Prof.dr. W. H. Lamers Dr. E. Wierenga Date: 2 - 5 April Location: AMC Most biomedical PhD students perform animal experiments at some stage of their research career, but most students have never received practical instructions with respect to the anatomy, histology and pathological anatomy of experimental animals. For this reason, experimental animals are usually not subjected to a thorough and systematic inspection to assess whether, besides the local (expected) effects in the organ(s) under study, other organs are affected as well. This annual course aims at providing insight(s) into the anatomy and histology of the mouse, presently the most frequently used animal species in cancer research. In addition, the course focused on the recognition of pathological changes in the mouse. During the course each student dissected either a male or a female mouse, to become acquainted with the topographic anatomy of this species. The microscopy part of the course focused on studying the architecture of normal and pathologically altered mouse tissues. During the practical part, recognition of cell and tissue types, and changes in architecture of tissues as a result of pathological processes, were studied microscopically. In addition to standard staining techniques, functional staining techniques were demonstrated. This year the practical part of the microscopical anatomy has been done with computerized sections and computer assisted magnifications. A total number of 7 PhD students and 4 Master Oncology students participated in the course. The overall evaluation rate was 7.3 (scale 1-10). Cancer Genome Analysis Organization: dr. R. Beijersberger dr. D. Peeper Date: 16 - 23 April Location: NKI With novel and highly sophisticated research tools we are now able to explore the complexity of the genomes of cancer cells at unprecedented depth and detail. Genomic and proteomic analyses have begun to reveal several factors involved in the initiation and progression of tumors. Using large-scale functional genomic approaches several new genes driving cancer have been identified, some of which are amenable to targeted therapeutic intervention. The massive amount of data generated by these large-scale

22 – Educational activities

approaches also calls for robust methods for data integration, computational biology and database mining. In this course, they addressed the developments and challenges in large-scale functional genomics, data integration and analysis. Together, these approaches should ultimately accelerate clinical progress. A total number of 25 PhD students participated in the course. The overall evaluation rate was 8.5 (scale 1-10). Combination of anti-angiogenics with radio- and chemotherapy to improve outcome of tumor and metastases response Meet-the-Expert with dr. A Haimovitz-Friedman Organization: dr. P. Sminia dr. M. Scharpfenecker Date: 4 -8 June Location: VUmc Dr. Haimovitz-Friedman and her team are investigating high single dose radiation effects on endothelial cells. They showed that ionizing radiation induces apoptotic cell death in endothelial cells, which is not dependent on p53, but on activation of the enzyme Acid Sphingomyelinase (ASMase). Furthermore, they showed that angiogenic factors such as bFGF protect endothelial cells from radiation-induced apoptosis and rescue mice from radiation-induced pneumonitis and radiation-induced GI syndrome. Her group also demonstrated that VEGF prevents radiation-induced apoptosis in the endothelium and that this was accomplished by repressing ASMase activation. Accordingly, delivery of anti-angiogenic agents immediately prior to radiation therapy induced ASMase activation in vivo, thereby synergistically increasing the endothelial apoptotic component of the tumor response and tumor cure. This strongly indicates that anti-angiogenic therapy acts as a radiosensitizer; however, this is not achieved by normalizing the tumor vasculature, but by increasing endothelial cell apoptosis. Dr. Haimovitz-Friedman research efforts are also dedicated to the introduction of radiosensitizers tested in preclinical animal models into clinical trials for cancer patients. A total number of 6 PhD students participated in the course. The overall evaluation rate was 8.3 (scale 1-10). Radiation Oncology Organization: dr. V. Lafleur Date: 4 -8 June Location: VUmc In the course ‘Radiation Oncology - Biological, Physical and Clinical Aspects’ the rationale for the use of radiotherapy in cancer patients will be elucidated. Topics of the course include: effects of irradiation on DNA, the cellular basis of radiotherapy, radiation

injury to tumours and normal tissues, the physical principles of radiotherapy and the use of radiotherapy in the treatment of common malignant diseases. Practical work in treatment planning of a virtual patient is part of the course. New and exciting developments in radiotherapy will be addressed as well. A total number of 20 PhD students and 11 Master Oncology students participated in the course. The overall evaluation rate was 3.7 (scale 1-5). Preclinical Assays in Cancer Therapy Organization: dr. V. Dangles-Marie, dr. J. Jonkers,

dr. E. Marangoni, dr. S. Rottenberg Date: 19 – 26 September Location: NKI Personalized cancer therapy requires detailed insight into the mechanisms underlying the response of individual tumors to (combinations of) targeted therapeutics and chemotherapy drugs. Understanding mechanisms of acquired therapy resistance is equally important since most patients with disseminated cancer eventually die due of tumors that are refractory to all available treatments. This 6-day course provided an overview of preclinical approaches aimed at understanding basic mechanisms of therapy response and resistance in order to improve personalized cancer therapy. The emphasis of this course will be on the use of genetically engineered mouse models and patient-derived xenograft (PDX) models for in vivo preclinical research, but also in vitro preclinical assays employing established tumor cell lines and functional genomics approaches were discussed. The course included a 3-day literature course, followed by a 3-day symposium with presentations from national and international experts. A total number of 20 PhD students participated in the course. The overall evaluation rate was 8.6 (scale 1-10). Targeting Tumor Vessels by Therapeutic Vaccination Meet-the-Expert with dr. A.K. Olsson Organization: prof. dr. A.W. Griffioen Date: 27 September Location: VUmc Vaccination is an attractive approach for many types of diseases. Broad vaccination programs have served to virtually eradicate disabling and life-threatening conditions such as polio, diphtheria and smallpox. The possibility to use vaccination as a treatment strategy also for cancer, allergy and inflammation, has for some time been the focus of intense research. There are however several reasons why development of vaccines for non-infectious disease is more difficult. First, the antigen to be targeted is a self-antigen, often expressed also under physiological conditions. Therefore, there is a need to break the self-tolerance of the immune system towards the antigen, in

Educational activities - 23

contrast to vaccination against a foreign virus or bacterial antigen. Second, tumor cells have developed mechanisms to evade recognition by the immune system, further complicating vaccination against tumor cell antigens. Third, when vaccinating against self-antigens it is important to use disease-specific targets. A small number of molecules have been identified as specifically expressed by tumor blood vessels, either by the endothelial cells themselves or by the adjacent stroma. These molecules are interesting targets for therapeutic vaccination against cancer, since they are absent in normal tissue and not expressed by the actual tumor cells, which often escapes the immune system. The participants of this meet-the-expert session had time to discuss the seminar, present own research, and discuss and/or brainstorm on these individual projects with dr. Olsson. A total number of 3 PhD students participated in the course. The overall evaluation rate was 9.0 (scale 1-10). Basic Microscopy Course “In the Footsteps of Antoni van Leeuwenhoek” Organization: Dr. J.A.M. Beliën

Dr. L. Brocks Dr. L. Oomen

Prof.dr. P. Peters Dr. E.A.J. Reits Dr. N van de Wel

Time: 8 - 11 October Location: VUmc/AMC/NKI This 5-day basic course covered a wide range of aspects of microscopy, starting with a short history of microscopy and basic principles of various forms of microscopy. Lectures, hands-on sessions covered the basics of image analysis and image processing, image measurement, electron microscopy, confocal microscopy and imaging (live cell imaging), fluorescence microscopy (time-lapse imaging and deconvultion) and correlative light and electron microscopy. During the course samples were prepared and examined. The participants could bring their own purified proteins solutions after consulting with the organization first. A total number of 20 students participated in the course. The overall evaluation rate was 4.1 (scale 1-5). Annual Graduate Student Retreat Organization: Prof.dr. T.K. Sixma P. Lagerweij Drs. C. Kapper Time: 17 – 19 October Location: Ermelo A highlight of the educational program is the Annual Graduate Student Retreat. This three-day retreat focuses entirely on research conducted by the

graduate students themselves. At the retreat, students not only present their work as a poster in the first year of their participation and as an oral presentation in subsequent years, they are also in charge of chairing sessions and discussions. In recent years, student participated in peer review of the presentation given by others in order to award the prize for the best poster and best presentation. In this manner, the retreat trains important skills in presentation and interaction but it also provides an overview of research conducted within OOA at a early stage of the student’s career, contributing significantly to the interaction between different groups: clinical and fundamental students. The location Hotel Opduin on the island of Texel reached its maximum capacity. This year the retreat was organized in Ermelo. A total of 124 students participated in this retreat. The overall evaluation rate was 4.1 (scale 1-5). Basic Medical Statistics Organization: Dr. M. Hauptman Date: 26 – 30 ovember Location: NKI This 5-day course was proceeded by a half-day introduction to the statistical software program SPSS, which was used during the course. The 2011 course had been adapted from the first course taught in 2010. Separate modules for clinical and experimental researchers are no longer offered, mainly because many participants of the 2010 course considered themselves as clinical and experimental researchers and because statistical methods in experimental research beyond the basic concepts are very specific to the field of application, with each of interest to only a select subgroup of participants. We also devoted more time to hands-on computer analyses of the participants, by providing datasets and exercises, and giving personal advice during those sessions. Despite the wide range of quantitative skills and data analysis experience and despite the heterogeneity of represented research fields, the course was well-received. A total of 22 PhD students participated in the course. The overall rating was 8.0 (scale 1-10).

24 – Educational activities


PhD research program

PhD research program - 27

4. PhD research program This chapter describes the 440 PhD projects conducted within the two main themes of the OOA research programs, with the names of the PhD students involved and their supervisor(s). * PhD students who obtained their PhD degree in 2012 # PhD students who stopped their PhD research in 2012 Funding 1 Financed by participating OOA institute (“eerste geldstroom”) 2 Financed by public funds (“tweede geldstroom”) 3-4 Financed by private funds (“derde / vierde geldstroom”)

Theme 1: Experimental Biology

Name Title of Project Supervisor Start Fund Biochemistry (NKI)

Blomen V. Functional Profiling of a Human knockout collection Brummelkamp 2010 1

Groothuizen F. Structural studies of DNA mismatch repair Sixma 2009 2

Hausmann J. Structural studies of autotaxin Perrakis 2008 4

Jae L. Identification of genes that play a role in human disease Brummelkamp 2011 1

Kim R. Regulation of the Usp7/HAUSP switch Sixma 2012 3

Mattiroli F. Structural and functional analysis of novel E3 ubiquitin ligase consisting of polycomb proteins BMl1 and Ring 1B

Sixma 2006 2

Nieuwenhuis J. Tissue control and the regulation of Hippo pathway activity in mammals

Brummelkamp 2012 4

Sahtoe D. Ubiquitin structure and function Sixma 2009 2

Smit J.J. Ubiquitin conjugation Sixma 2007 4

Staring J. Tissue size control and the regulation of Hippo pathway activity in mammals

Brummelkamp 2010 4

Uckelmann M. The balance of ubiquitin conjugation and deconjugation Sixma 2011 4

Biological Stress Response (NKI)

Harmsen T. Oligonucleotide-directed gene modification in human induced pluriipotent stem cells

Te Riele 2011 4

Harn van T. Role of the G2 restriction point in tumor development and behaviour

Te Riele 2007 3

Hogenbirk M. A Cancer Genome Atlas of the activation induced cytidine deaminase novel insights into the pathogenesis and prognosis of B cell lymphoma

Jacobs 2008 3

Houlleberghs H. Characterisation of unclassified allelic variants of DNA mismatch repair genes to improve genetic counceling

Te Riele 2010 4

Rooswinkel R. Improvement of chemoradiotherapy in head and neck cancer by small molecule inhibitors of Bcl-2

Verheij 2008 3

Seeman I. The role of endoglin in induction and repair of cardiovascular damage after radiation alone or in combination with trast

Stewart 2008 3

Wit N. A cancer Genome Atlas of the activation induced cytidine deaminase

Jacobs 2008 3

28 – PhD research program

Wielders E. Subtle gene modification to study the role of the mismatch repair complex Msh2/Msh5 in mutation avoid

Te Riele 2004 3

Cell Biology I (NKI)

Boekhout M. Spindle Checkpoint independent control of the APC/C Wolthuis 2010 4

Clijsters L. Targeting protein destriction during cell division Bernards 2007 3

Elbatsh A. Dissecting the prophase pathway of cohersin removal Medema 2012

Ellenbroek S. Tiam1/Rac signaling and wnt/beta-catenin-induced tumorigenicity

Collard 2004 3

Elouarrat D. Regulation of sirt1 and downstream targets by phosphoinositides

Moolenaar 2005 4

Feringa F. Spontaneous recovery after DNA damage Medema 2011 4

Frijns E.* Controlling hemidesomosome dynamics by phosphorylation of residues on the integrin beta4

Sonnenberg 2007 2

Galovic M.* Casein kinase 2-dependent regulation of N-wasp function in endocytosis

Innocenti 2009 1

Houben A.* Autotaxin, a secreted lyso PLD: role in tumor progression Moolenaar 2006 3

Kedziora K. Calcium and phosphoinositides in the control of podosome formation and tumor cell invasion

Jalink 2010 3

Ketema M.* Analysis of the function of a novel nuclear envelope protein, nesprin 3 in anchoring the nucleus to the intermediate filament system

Sonnenberg 2005 2

Leyton Puig D. Super-resolution Microscopy (Nanoscopy): From sharp images towards imaging of molecular interaction

Jalink 2011 4

Margadant C. Generation of a mouse model for EBS-MD Sonnenberg 2006 4

Mertens S.# Initiation and progression of lymphomas and skin carcinogenesis in Tiam1 mutant mice

Collard 2001 3

Nahidi Azar L. Super-resolution Microscopy("Nanoscopy"): From sharp images towards imaging of molecular interaction

Jalink 2011 4

Sachs N. Function of integrin-CD151 complexes in tumor cell invasion and metastasis

Sonnenberg 2004 3

Veen, van M. Autotaxin and GDE2: functional and structural analyses Moolenaar 2011 2

Visser D. TRPM7 a novel regulator of cytoskeletal tension implications for cancer progression, invasion and metastasis

Jalink 2007 3

Voets E. Divergent control of Cyclin B1-Cdki in cancer cells: a key role in therapy

Wolthuis 2008 3

Cell Biology II (NKI)

Afanasyev P. Analysis of 3D structure of molecular machines with cryo-electron tomography using novel nanochambers

Peters 2011 4

Albers H.* Chemical biology of phosphate ester hydrolysis Ovaa 2007 2

Bakker J. Towards understanding and manipulation of MHC class II antigen presentation

Neefjes 2010 4

Deventer, van S. Kinome and phosphatome knock-down Neefjes 2008 2

Ekkebus R. Pan DUB inhibitors to study the ubiquitinated proteome Ovaa 2009 2

Hoppes R. Characterization of peptide-MHC interactions Ovaa 2007 2

Jong de A. Post-Translational transpeptidation and immunity Ovaa 2009 2


Jongsma M. Manipulating the MHC class II system to control immune responses in auto immunity

Neefjes 2007 2

Kant van der R. Manipulating the MHC class II system to control immune responses in auto immunity

Neefjes 2007 2

Leestemaker Y. Proteasome activation Ovaa 2011 1

Leeuw de R.* Nuclear receptors in targeted cancer therapy Michalides 2007 4

Luimstra J. Mass cytometry staining agents for combinattorial MHV- exchange Tcell coding

Ovaa 2012 1

Pang B. Manipulation of phagosomal pathways Neefjes 2006 2

Paul P.* Finding new players in MHC class II Ag presentation Neefjes 2006 2

Schunselaar L. Drug responses with primary cultures of tumor cells from mesothelioma patients

Neefjes/Baas 2012 1

Shahul Hameed S. Engineering Ubiquitin Related Proteins to Reveal their Function

Ovaa 2009 4

Wijdeven R. Towards underfunding and manipulation of MKC clan II antigen presentation

Neefjes 2009 1

Witting K. UPStream Ovaa 2012 4

Wu L. Towards underfunding and manipulation of MHC clan II antigen presentation

Neefjes 2010 4

Gene regulation (NKI)

Bemmel van J.* Multi-gene chromatin domains Van Steensel 2007 2

Bos A.# Genetic screens to identify cancer related functions of human microRNAS

Agami 2008 3

Brinkman E. Nuclear lamins and chromosome organization Van Steensel 2012 4

Chen T. Principles of chromatin organization Van Steensel 2012 4

Drost J.* Identification and characterization of human tumor suppressor genes in the p53 pathway

Agami 2005 3

Kouwenhove van M.*

Role of miRNA genes in etiology of germ cell tumors and derived malignant tumors

Agami 2007 3

Lopes R. Identification of Mirnas regulatory mechanismus in cancer Agami 2011 4

Melo C. mcRNA’s and cancer Agami 2009 4

Rooijers K. Analysis of ribosome profiling data Agami 2011

Terweij M. Chromatin dynamics and epigenetic changes Van Leeuwen 2009 4

Vlaming H. Role of histone mthyltransferase Dot1 in gene expression and leukemic transformation

Van Leeuwen 2010 2

Wilting R. The role of class I HOACs in normal physiology tumorigenesis and transcriptional regulation

Dannenberg 2009 3

Immunology (NKI)

Ariotti S. Introvital imaging of epidermal imunne phenomene in virus infections and DNA tattooing

Haanen 2007 1

Buuren van M. The use of MHC-tetramer technology to characterize HCV specific T-cell responces

Schumacher 2010 4

Ciampricotti M. The inflammatory tumor microenvironment and its impact on signal cancer development and therapy

De Visser 2009 2

Deken M. Combining ragerted therapy and immunotherapy Blank 2012 2


Dijkgraaf F. Intravital imaging and computational ignallin of skin immunity

Schumacher 2012 4

Doornebal C. The role of cancer cell-interinsic and microenv. Factors contr. to metastasis formation and its modulatation by opioid

De Visser 2009 1

Hooijkaas A. Generation of melanoma-specific immune responses Blank 2012 4

Kelderman S. Development of adoptive T-cell therapies Schumacher 2009 1

Kersten K. Cancer cell-intrinsice and-extrinsic regulation of breast cancer metastais formation, implications for adjuvant therapy

De Visser 2011

Kooij van de B. A novel type of ubiguintination regulates apoptosis signalling by BH3 only protein Bid

J.Borst 2008 2

Linnemann C. Preclicinal development of TLR gene therapy for prostate carcinoma

Schumacher 2008 2

Mezzadra R. Development of TCR1Ano vector 1 items for TCR gene therapy

Schumacher 2010 2

Oosterhuis K.* Treatment of HPB positive penicle and cervical cancer by introduction of NPV7 special TCI

Haanen 2006 2

Veraar E. TNF ligands in cancer: CD70 J.Borst 2006 4

Molecular Oncology (NKI)

Durmus S. The impact of ABC transporters on carcinogen resistance Schinkel 2009 1

Gogola E. Resistance to PARP inhibition by DNA damage response alterations

Rottenberg/Jonkers 2012 3

Iskit S. Dissecting the essential contribution of FRA-1 to human tumor cell metastasis

Peeper 2009 4

Iusuf D. OATP1A/1B(SLCO1A/1B) drug uptake transporters in anticancer drug pharmacokinetics and toxicity risks; possible strategy

Schinkel 2008 3

Kaplon J. The relationship between cell metabolism, sencescence and cancer

Peeper 2007 2

Peuscher M. Novel factors involved in chromosome END protection by telomeres

J.Jacobs 2007 3

Tang S.C. Impact of apical ABC transporters and cytochrome P450 3A and novel tyrosine kinase inhibitor anticancer drugs

Schinkel 2009 4

Torre van der J. Novel factors involved in chromosome end protection by telomeres

J.Jacohs 2006 3

Xu G. Selective targeting of DNA damage response to eradicate. HR-deficient tumors

P. Borst 2009 3

Zander S. Mechanisms of chemotherapy resistance of spontaneous mammary tumors in genetically-engineerd mouse models

P. Borst 2007 2

Molecular Carcinogenesis (NKI)

Brunen D. Finding genetic dependencies in cancer: the missing link in personalized medicine

Bernards 2012 3

Dyk van E. Modularity and Complex Interaction in Cancer Wessels 2009 2

Groenendijk F. ERC functional genomics Bernards 2010 4

Heynen G. Determinants of the breast cancer stem cell phenotypes Bernards 2008 2

Kuiken H.J.* HCS/HT using RNAi technology Beijersbergen 2005 4

Jong de J. Modularity and Complex Interaction in Cancer Wessels


Lint de K. Dissecting genetic dependencies in cancer Bernards 2010 4

Nijwening J.* Development & application of shRNA in cell based screening technologies

Beijersbergen 2004 4

Prahallad A. Coltheres Bernards 2010 2

Ronde de J. CTMM - Breastcare Wessels 2008 4

Staiger C. Subnetwork module construction for imporved diagnostic classification and subtyping

Wessels 2009 1

Sun C. Targeting protein destruction during cell division Bernards 2010 4

Wang L. Cancer Genomics Center Bernards 2012 4

Molecular Genetics (NKI)

Alendar A. Identificaiton of the PIM regulatory network by micro array analysis and high through put retroviral tagging

Berns 2002 3

Galen van P. Genetic screening approaches to the characterization of human blood and leukemia development

Van Lohuizen 2008 4

Gisler S. Role of Polycomb repressors in reprogramming and breast cancer

Van Lohuizen 2011 4

Ikink G. Identification and Characterization of Novel Breast Cancer Genes Collaborating with ErbB2

Hilkens 2010 1

Isogai T. Understanding the role of filopodia in cell migration Innocenti 2009 1

Koppens M. Role of Polycomb repressors in prostate cancer and breast cancer models

Van Lohuizen 2009 2

Montfort van E.H.M

Development of a mouse model to study the genetic basis of malignant mesothelioma

Berns 2000 3

Velden van der Y. The role of lkB1 in tissue morphogenesis and cancer zebrafish

Haramis 2005 2

Vissers J.* Regulation of histone H2A monoubiquitination by Ring 1b/Bmi1 and USP3 in DNA damage respons

van Lohuizen 2006 4

Clinical Epidemiology and Biostatistics (VUmc)

Wubulikasimu A. Evaluation of classification strategies for colorectral cancer

Meijer 2009 1 and 2

Clinical Genetics (VUmc)

Adank M. Breast cancer predisposition Meijers 2007 2

Bakker J.L. Molecular and phenotypic consequences of the CHEK2*1100delC mutation and targeted therapy for breast cancer that lacks CHEK2

Waisfisz 2009 1

Corbin M. Human Genes essential for the defense against oxygen toxicity

Joenje /Dorsman 2008 3

Dommering C.J. Retinoblastoom en erfelijkheid Meijers 2006 1

Greuter M. ASCCA (Adenoma and Serrated pathway to Colorectal CAncer)

V. Coupe 2012

Haitjema A. Proteins interacting with FANCI and PALB2 Joenje / Dorsman 2008 3

Massink M. Molecuar classification of familial breast cancer Joenje / Waisfisz 2008 2

Mol B.M. Molecular carcinogenesis of retinoblastoma Dorsman / Cloos 2008 3

Stoepker C. The Fanconi anemial/BRCA pathway in oral squamous cell carcinomas

Joenje / de Winter 2008 1

Kooi E.I. Genomics to improve diagnostics and care of retinoblastoma patients

te Riele 2011 3

Gastroenterology (VUmc)


Radersma M.# Is c-Abl a potential target for therapy in Enteropathy Associated T-cell Lymphomas?

Mulder 2010 3

Hematology (VUmc)

Leeuw de D.C. Uncovering the molecular pathways (microRNAs) that regulate tumor-initiating potential of Leukemic stem cells

Smit 2009 3

Kerkhoff N. Role of immune responses focussing on DC in the pathogenesis of low and high risk Myelodyplastic syndromes: implications for immunotherapy

Ossenkoppele, van de Loosdrecht

2012 1

Ruben J.M.# Leukemia associated antigen loading of dendritic cells for vaccination of acute myeloid leukemia patients

Van de Loosdrecht 2009 3

Wojtuszkiewicz A. The role of impared FPGS splicing in methotrexate response in childhood acute lymphoblastic leukaemia

Jansen 2010 3

Medical Oncology (VUmc)

Heusschen R.# Targeting galectin-1 for the diagnosis and treatment of cancer

Griffioen 2009 3

Hodzic J. Identification of genes involved in resistance of prostate cancer cells to irradiation

Van Beusechem 2009 3

Lindenberg J.J.# Adenovirus-based and CD40-targeted in vivo tumor vaccination

De Gruijl 2006 2

Roemer M.G.M. Characterizing genetic alterations in diffuse lage B-cell lymphomas occuring in immune provileged sites

de Jong 2012 3

Schneiders F.L. iNKT and Vγ9Vδ-T cell based immunotherapies for solid tumors

Van der Vliet 2009 1

Siebring van Olst E.

Identification of genes involved in resistance of lung cancer cells to cisplatin

Van Beusechem 2009 3

Warmoes M. Proteomics of breast cancer Boven 2007 4

Medical Microbiology and Infection Control (VUmc)

Ates L.S. Live mycobacterium bovis BCG bacteria as a platform for the induction of enhanced tumor-antigen-specific immunity

Bitter 2011 1

Molecular Cellbiology and Immunology (VUmc)

Braster R. Identification of tumor-derived proteins that modulate macrophage effector functions

Beelen 2011 1

da Silva Aresta Belo van Wijk A.I.

Galectins in tumor progression and tumor immunology Van Kooyk 2009 4

Grewal S. Coelctomy enhances tumor cell adhesion in the liver and subsequent outgrowth of metastases

van Egmond 2011 2

Gül N.* Prevention of tumour recurrence by blocking surgery-induced adherence of colon carcinoma cells to exposed extracellular matrix components

Beelen 2007 1

Neurology (VUmc)

Groot de M. Correlation between SV2A expression in tumour tissue and efficacy of levetiracetam in glioma patients with epilepsy

Reijneveld 2008 4

Rijn van S. Modulation of miRNAs in glioma stem-like cells Würdinger 2009 3

Sewing L. Developing mouse models of diffuse intrinsic pontine glioma (DIPG) for pre-clinical research

Kaspers 2012 3

Oral and Maxillofacial Surgery and Pathology (Vumc)

Weijers M.* Oral squamous cell carcinoma; some epidemiological and clinicopathological aspects

van der Waal 2004

Otolaryngology/ Head and Neck Surgery (Vumc)

Graveland A.P. Molecular diagnostis of head and neck squamous cell carcinoma (HNSCC)

Brakenhoff 2005 3


Kemp de S.R. Determinants of chemotherapy sensitivity Braakhuis / Brakenhoff

2007 1

Plas van der M. Identification of oncogenic microRNAs and classical cancer genes involved in head and neck SSC by a functional genomics approach

Brakenhoff / Braakhuis

2008 3

Pathology (VUmc)

Bierkens M. Genetic profiling of CIN 3 lesions diagnosed in the subsequent screening round following screening by HPV testing and cytology

Snijders / Steenbergen

2007 1

Bosch L.J.W. Methylation for Early Colorectal Cancer Detection Meijer 2005 4

Broek E. van den Structural chromosomal rearrangements in colorectal cancer

Meijer 2011 1

Groen F.L.M. de Identification of novel oncogenes/oncomirs located at 13q involved in the progression of colorectal adenoma to carcinoma

Meijer 2010 1

Hiemstra A.C. Development of an improved molecular test for population-wide colorectal cancer screening

Meijer 2011 3

Hoebe E.K.# Role of soluble BARF1 oncoprotein in Epstein-Barr virus driven carcinogenesis and its functional inhibition by antibodies

Middeldorp 2007 3

Lavaei M.# Proteomics of exisomes secreted by cancer cell lines Jimenez 2010 3

Louwers J.A.* The role of digital colposcopy, the human papillomavirus and biomarkers

Meijer 2005

Miok V. Comprehensive molecular characterisation of a longitudinal in vitro model of high-risk HPV-mediated transformation

Snijders 2012 3

Reinen E.# Genetic profiling for risk assessment of preneoplastic endobronchial lesions

Snijders / Smit 2007 3

Rijkaart D. Stratifying high-risk HPV positive women for risk of CIN 3 and cervical carcinoma by HPV transcript analysis

Snijders / Meijer 2006 3

Scheinin A.I. Data mining DNA copy number changes in cancer Meijer 2011 3

Scherpenisse M. Immunity against Human Papilloma Virus Meijer 2008 3

Thuijl H.F. van Chromosomal aberrations associated with progression characteristics of low-grade glioma patients

Heimans 2010 3

Turksma A. Towards adjuvant immunotherapy for squamous cell carcinoma

Hooijberg / Meijer / Leemans

2007 3

Wildeman M.# Early detection of primary and recurrent nasopharyngeal carcinoma (NPC) using (anti-) EBV based tumor markers and option

Middeldorp 2008 3

Wit de M. Molecular imaging of colorectal cancer Meijer / Fijneman 2006 4

Paediatrics (VUmc)

Wouters R Clonal evolution of acute myeloid leukemia stem cells Cloos 2012 3

Biomedical Engineering and Physics (UvA)

Bremmer R. Reflectance Spectroscopy on Ageing Blood Stains Van Leeuwen 2007 2

Bruin de D.M. Reflectance Spectroscopy on Ageing Blood Stains Van Leeuwen 2007 1

Kodach V.* IR swept source for high resolution functional imaging in medicine

Van Leeuwen 2007 3

Cell Biology & Histology (AMC/UvA)

Gentek R. Signaling partners of Notch in oncogenesis Kapsenberg / Amsen 2008 1

Center for Experimental Molecular Medicine (AMC/UvA)

Balzarolo M. Regulation of TRAIL in immune cells Wolkers/ Medema 2008 1


Colak S. Cancer stem cells in colon carcinoma; their flexibility, role in tumor growth and therapy resistance

Medema 2008 2

Damhofer H. Pranceatic cancer stem cells Medema / Bijlsma 2010 1

Fessler E. Microenvrionmental regulation of CSC Medema 2011 1

Guadagnoli M. TNF ligands in cancer Medema 2007 3

Lascano V. Cancer stem cells in colon carcinoma; their flexibility, role in tumor growth and therapy resistance

Medema 2008 3

Potze L. Applicability and mechanism of Betlinic Acid induced tumor killing

Medema 2009 3

Prasetyanti P.R. Survival and differentiation of Colon Cancer Stem Cells Medema 2010 3

Shi K. Role of Blood coagulation in pancreatic cancer Richel / Spek 2010 1

Sousa E Melo de F. Epithelial mesenchymal interaction in colorectal cancer Medema 2008 2

Van der Heijden M.

Stem cell biology and cancer Medema 2012 1

Van Oorschot B. Prostate cancer radiation side-effects Medema 2011 3

Zimberlin C.D. Mouse models for colorectal cancer Medema / Bots 2010 1

Clinical chemistry (AMC/UvA)

Besancon O.G. Preclinical screening of drug combinations for neuroblastoma

Caron/ Tytgat/ Kuilenburg

2008 3

Cuperus R. Modulation of fenretinide induced cell death in neuroblastoma

Caron / Kuilenburg 2004

Experimental Biology (AMC/UvA)

Attekum van M.H.A.

The role of TNFr-family member APRIL on the proliferation and survival of CD5+ B-cells in chronic lymphoceutic leukemia

Van Oers/Kater 2011 1

Heer de K. Kinetcs and homing of CLL cells Van Oers/ Eldering 2010

Jak M.* Microenvironment and anti-CD20 based therapies in CLL Van Oers/ van Lier 2007 4

Raa te D. Improving Outcome of P53 Dysfunctional Chronic Lymphocytic Leukemia by Early Detection and Circumvention of the P53 Pathway

Van Oers/Eldering/ Kater

2010

Schot J.J. The role of TNFr-family member APRIL on the proliferation and survival of CD5+ B-cells in chronic lymphoceutic leukemia

Van Oers/Eldering/ Kater

2009 3

Tromp J.* The Noxa/Mcl-1 axis as therapeutic target in CLL Van Oers/ Eldering 2007

Gastroenterology (AMC/UvA)

Davelaar A.L. Proteases as biomarkers and analytical tools in inflammatory diseases of the gastro-intestinal tract associated cancers

Fockens/ Krishnadat 2008 1 and 3

Luijtgaarden van de W.

Evaluation of Dendritic cell immunotherapy in combination with Curcumin for treating esophageal cancer

Krishnadat 2009

Pacha A.F. Evaluation of Dendritic cell immunotherapy in combination with Curcumin for treating esophageal cancer

Krishnadat 2008 3

Timmer M. Evaluating molecular strategies for treatment of Barrett's esophagus

Krishnadat 2011 3

Westra W.M Investigating molecular targets for treatment of Barrett’s esophagus

Krishnadat 2008 2

Human Genetics (AMC/UvA)

Ammerlaan A.C.J. Genetic profiling of gliomas and their recurrences for improvement of diagnosis and prognosis

Hulsebos / Versteeg 2002 3


Both J. Role of oncogenes in chromosome region 17p11.2-p12 Baas/ Hulsebos 2007 3

Bunt J.* Role of OTX2 in medulloblastoma Versteeg 2005 1

Groningen van T. The role of Notch signalling in Neuroblastoma Versteeg 2008 2

Lamers F.* Drug targets in the apoptotic route in Neuroblastoma Versteeg/ Caron 2007 4

Nowakowska N. Drugging oncogenic pathways in neuroblastoma Versteeg 2009

Pathology (AMC/UvA)

Andel van H. Wnt-signalling in the pathogenesis of Multiple Myeloma Pals/ Spaargaren 2011 3

Hoogeboom R. Identification of antigen receptor ligands of B-cell lymphocytic leukemia immunoglobulin-homology groups

Van Noesel/ Bende 2007 3

Keimpema van M. The role of the forkhead transcription factor FOXP1 in B-cell non-Hodgkin lymphoma

Pals/ Spaargaren 2008 3

Mackovicová K. Targeting of Activation-induced Cytidine Deaminase (AID) dependent DNA Double-stranded Breaks and Long-range DNA interactions

Van Noesel / Guikema

2010 1

Matlung S.E. BASIS genetische analyse van mammacarcinomen; (Breast Cancer Somatic Genetics Study)

Van de Vijver 2011 2

Rooij de M. The role of N-cadherin in Multiple Myeloma Pals/ Spaargaren 2009 1

Savci C.D Identification and validation of predictive markers for drug response in metastatic breast cancer.

Van de Vijver 2009 4

Slot L. Chronic antigenic stimulation and development of low-grade B cell non-Hodgkin (NHL) lymphomas

Van Noesel / Bende 2010 3

Theme 2: Experimental Clinical Research

Name Title of Project Supervisor Fund Molecular Pathology (NKI)

Beelen K. Clinical and molecula evaluation of anti-estrogen resistance in breast cancer

Linn 2009 4

Broek, van der S. Genetic determinants of survival and second breast cancer development in premenopausal breast cancer patients

Van 't Veer 2009 3

Bronsveld H. CARING Schmidt 2012 2

Dackus G. Applied breast cancer diagnostics T3-502 Linn 2012 3

Droog M. Molecular mechanism of endocrine resistance Zwart 2011 1

Drost R.* Therapy responses of BRCA-mutated tumors and role of PALB2 in mammary tumorigenesis

Jonkers 2006 3

Flach K. A genomics-based tool to predict tamoxifen response Zwart 2012 4

Frederix F. Cost effectiveness of breast cancer therapies Schellens 2009 4

Geel van, R. Clinical Pharmacology of out-coude drufs Schellens 2011 4

Hasselt van C. Population PK-PD-modelling in oncology Schellens 2009 4

Jacobs B. Development and clinical testing of novel formulations for oral fluoropyrimides

Schellens 2011 1

Jaspers J. The role of tumor-initiating cells in cancer metastasis and drug resistance

Jonkers / Rottenberg 2008 2

Jibodh A.# Clinical pharmacology anticancer drugs Schellens 2012 1


Jong, de M. Prediction of local control after radiotherapy in head and neck cancer

Begg 2007 3

Kas S. Identification of genes nvolved in breast cancer development and therapy resistance

Jonkers 2011 2

Koornstra R. Predicting hormonal treatment sensitivity in breast cancer

Linn 2007 4

Leijen S. Development of contribution therapy with anti cancer drugs

Schellens 2008 4

Meulendijks D. Phase Iand II studies in oncology with focus on gastro-intestinal malignancies

Schellens/Cats 2011 4

Milojkovic B. Clinical Pharmacology of anti-cancer drugs Schellens 2011 4

Noll, van der N. Clinical Pharmacology of novel tyrosine kinase inhibition Schellens 2010 4

Parsi, P. Cancer risk and insulin analogues (CARING) Schmidt 2012 4

Salomon I. Microban Linn 2005 2

Schouten P. Prediction of chemotherapy response based on genomic aberrations

Linn 2010 2

Severson, T. Molecular characterization of ER positive, triple negative and BRCA1 mutated breast cancer

Linn 2012 2

Stuurman R. Orale pharmacology van taxanen Schellens 2009 4

Verhagen C. Fanconi anemia pathway defects in HNSCC Begg 2008 1

Vollebergh M. Predicting therapy responses in breast and lung cancer Linn 2007 3

Medical Oncology (NKI)

Alphen van M. Virtual Surgery in Oral Cancer Van der Heijden 2012 1

Backer, de R. # Clinical fharmcological with wee 1 inhibitor MK1775 Schellens 2010 4

Boshuizen R. Selectikine/EMD malegrant pleural effusion Van der Heuvel 2009 4

Djajadiningrat R. Penile squamous carcinoma Horenblas 2011 1

Dohmen A. Short term cultures of NSCLC and HNSCC for manipulating and predicting treatment responses

De Zuur 2011 4

Dubbelman A.* ADME and main balance of anticancer drugs Schellens/Beijnen 2008 4

Jongh, de E. # Effectivity anti-cancer therapy Schellens 2007 4

Keizer R. Population pharmacokinetics and pharmacodynamics of investigational anti-cancer agents

Schellens/Beijnen 2006 4

Kist J. Towards personalised treatment based on evaluation of ET in recurrent differentiated Hyroid cancer

Vogel 2011 3

Kuijpers A. Pathway activation in colorectal carcinoma and colorectal metastasis

Verwaal 2012 1

Mertens L. Bladder Cancer Horenblas 2011 1

Mirck B. Surgery for metastatic colorectal cancer Verwaal 2011 4

Moes J. Oral Taxanes: pharmaceutical and clinical development group pilot programme transletinal onderzoek

Schellens/Beijnen 2007 2

Nijenhuis C. Bioanalysis, metabolism and clinical pharmacology of anticancer drugs (vemurafenib)

Beijnen/Schellens 2012 4

Pengel K. CTMM breast care Gilhuijs 2009 4

Samuels, S. Safety ethicary and immunogenicity of HPV16E1 caccination in HPV related squamous cell cancer

Kenter 2012 1


Schaake E. Individualised therapy in thoracic malignancies Burgers 2009 4

Stiekema J. Genetic Profiling in Oesophageal Cancer Van Sandick 2010 4

Stoker S. Nasopharyngeal carcinoom Tan 2011 3

Swellengrebel M. Optimizing peri-operative treatment of rectal cancer Cats/Marijnen 2008 4

Uyterlinde W. Supportive care in the treatment of NSCLC v.d. Heuvel 2008 1

Wessels R. Optical vuvar biopsy by optical coherence tomography (DCT)

van Beurden 2010 1

Wildeman M. Early detection of primary and recurrent nasopharyngeal carcinoma using (anti-) EBV based tumor markers and option

Tan 2008 3

Pharmacy and Pharmacology (NKI)

Aalbergsberg E. Molecular imaging of radiolabeled cisplatin Vogel 2012 1

Fan L. The impact of ABC transporter in the Blood-Brain Barrier on the brain penetration of drugs and their efficacy against in

Beijnen 2009 4

Radhakishun N. The effects and treatment of obesity in children and adolescents

Van Vliet 2011 1

Psychosocial Research and Epidemiology (NKI)

Boekel N. Cardiovascular morbility and mortality in breast cancer survivors

van Leeuwen 2008 3

Eggermond van A. Long term risk of second hand cancer and cardiovascular disease followeing treatment of Hodgins lymphoma

Floor van Leeuwen 2009 3

Eijzinga W. Identification of psychosocial problems and perceived need for support in cancer genetics

Bleiker 2008 3

Feenstra H. An online testing approach to assess cognitive problems associated with cancer and cancer treatment

Schagen 2011 3

Groot H. Longterm risk of cardiovascular disease + 2nd malignancies after platinumbased CT for malignant testicular germcell canc

Schaapsveld 2012 3

Hummel, L. A randomized study of an internet-based cognitive behavioral therapy program for sexuality and intimacy problems in women

Aaronson 2012 3

Kemperman M. CONNECT Cognition and the Neural Network: Effect of Chemotherapy

Van Leeuwen 2010 1

Krul I. Late effects of treatment in female survivors of Hodgkin's lymphoma with an emphasis on premature menopause

Floor van Leeuwen 2012 3

Kuijpers W. ACARE2 MOVE. IT supported patient empowerment Van Harten 2010 3

Menning S. Structural biochemical and functional indices of CF inducted cognitive deficits in concepts

Schagen 2010 3

Meulepas J. Cancer risk due to radiation exposure from paediatric computed tomography

Hauptmann 2011 2

Miquel Cases A. CTMM-breast Van Harten 2011 4

Nimwegen, van R. Long term cardiovascular risks after treatment for Hodgkin Lymphoma

Van leeuwen 2010 3

Rayan A. Eurocan Van Harten 2011 4

Rosmalen van A. # The role of early life-style factors in the etiology of breast cancer

Rookus 2001 4

Schrijver L. Gene-hormone use interactions in BRCA 1/2 mutation carriers: modification of breast and ovarian cancer risk within CIMBA

Rookus 2010 4


Spaan M. OMEGA, long term risk of cancer after ovarian stimulation for in-vitro fertilization

Van Leeuwen 2010 3

Verloop J. Long-term effects f exposure to DES in utero on the risk of hormone-related cancers

Van Leeuwen 2001 3

Waart van H. Effectivities of physical exercise Aaronson 2009 3

Wevers M. Behavioral and psychosocial effects of rapid genetic counseling and testing in newly diagnosed breast cancer patients

Aaronson 2008 4

Radiotherapy (NKI)

Boer, de J. image guided corretion strategies to optimize RT precision

Sonke 2006 3

Bohoslavsky R. Probabilistic based treatment planning with biological objectives for high dose high-presision RT of prostate cancer

van Herk 2008 3

Chen W. Neoadjuvant drug treatment for breast cancer-response prediction and response monitoring: breast care

Sonke 2009 4

Dees-Ribbers H. High precesion image guided RT for bladder cancer Van Herk 2008 3

Haan de R. Radiotherapy and PARPI ui NSCLC/MNSCC/LABC-clinical studies

Verheij/Schellens 2011 4

Hamming-Vrieze O.

Dose redistribution in the presence of anatonmical changes in head and neck cancer

Rasch 2011 1

Heukelom J. ARTFORCE-Adaptive and Innovative Radiation Treatment For Improving

Verheij 2012 2

Kranen, van S. High precision radiotherapy in the presence of anatonical deformations

Van Herk 2005 3

Kruis M. Motion compensation in YD PET Boellaard 2009 4

Leij van der F. Image guided pre operative accelerated partial breast radiaton efining radiotherapy sensitivity

Elkhuizen 2010 3

Mencarelli A. High precission RT in presence of anatomic changes Sonke 2008 1

Nijkamp J.* Optimizing radiotherapy treatment of rectal cancer patients

Verheij 2009 1

Peulen H. Optimization of sterotactic image guided RT for lung cancer through detailed toxizing assessment

Sonke 2011 3

Trip A. Adjuvant treatment maagcarcinoom i.h.h. critics Verheij 2011

Zhang H. IGRT-Breast care package Sonke 2009 1

Gastroenterology (VUmc)

Pas van der M. To study possibilities of fluorescence as tool to optimise staging and preoperative localisation of colon carcinoma

Meijerink 2007 2

Water van de J.M.W.

Predicting T-cell lymphoma development in refractory coeliac disease patients by profiling of apoptosis pathways

Cillessen 2007 1

Hematology (VUmc)

Alhan C. Role of flow cytometry in the diagnosis and prognostication of myelodysplastic syndromes

v.d. Loosdrecht 2008 4

van Alphen C. Phosphoproteomics for personalized treatment of acute myeloid leukemia with kinase inhibitors

Ossenkoppele, Janssen

2012 3

Ancker, van den W.

Optimizing strategies in dendritic cell vaccination in myeloid leukaemia

v.d. Loosdrecht / Ossenkoppele

2006 1


Issa D.E. Treatment and survival of indolent and aggressive NHL patients; population based studies in the Netherlands

Huijgens 2009 4

Luijn, van M.* Regulation of MHC class-II in acute myeloid leukemia and its impact on immunoserveillance

v.d Loosdrecht / Ossenkoppele

2006 3

Niewerth D. Application of bortezomib in pediatric acute lymphoblastic leukemia

Kaspers 2009 3

Terwijn M. Detection of residual leukemic stem cells during minimal residual disease in AML

Schuurhuis / Ossenkoppele

2006 3

Verhagen H. The identification of biomarkers/drugtargets specific for leukemic stem cells of Acute Myeloid Leukemia

Smit 2011 3

Wondergem M.J. Can transformation of indolent lymphoma be detected at an early stage by PET scanning?

Huijgens / Hoekstra 2006 1

Zeijlemaker W. The role of minimal residual disease, and leukemic stem cells herein, in clinical decision making

Ossenkoppele 2011 3

Medical Oncology (VUmc)

Avan A. Genetic and molecular mechanisms underlying Pancreatic Ductal Adenocarcinoma aggressive behaviour and chemoresistance

Peters, Giovannetti 2011 3

Azijli K. TNF ligands in cancer: TRIAL for cancer therapy Peters 2008 3

Giovannetti E. Correlation of cytidine deaminase and DNA repair genes polymorphisms with response and survival in advanced NSCLC patients

Peters 2007 4

Gotink K.J. Sensitivity and resistance of tumor cells to the antiangiogenic tyrosine kinase inhibitor sunitinib

Verheul 2008 3

Huijts L. Phase I-II study of everolimus and low-dose oral cyclophosphamide in patients with metastatic RCC

Verheul 2011 3

Koster B.D. Immunomodulation of the sentinel lymph node de Gruijl 2012 3

Kuipers L. Cancer therapy with the proteasome inhibitor Bortezomib and the death ligand TRAIL for non-small cell lung cancer

Peters 2008 3

Lam S.W. A multicenter, randomized phase II trial of paclitaxel plus bevacizumab versus paclitaxel, bevacizumab plus capecitabine

Boven 2010 4

Neefjes E.C.W. Early recognition and optimal treatment of delirium in patients with advanced cancer

Verheul 2011 3

Neerincx M. Individualized treatment of patients with advanced colorectal cancer based on miRNA expression profiling

Verheul 2011 3

Offringa T. Chemotherapy and maximal tumor debulking of multi-organ coloractal cancer metastases

H. Verheul, T. Buffart

2012 5

Schulkens I. Exploring the role of endothelial galectins in tumor angiogenesis

Griffioen 2009 3

Versteeg K.S. Optimalization of systemic treatment strategies in elderly patients with advanced solid malignancies

Verheul 2012 3

Walraven M. Platelet proteomics for cancer biomarker discovery Verheul/Jimenez 2008 3

Wentink M. Development of a therapeutic vaccine approach to anti- angiogenesis in oncology

Verheul H 2012 4

Neurology (VUmc)

Froklage F. Assessment of blood-brain barrier function in pharmacoresistant patients with tumor-related epilepsy

Reijneveld 2008 2

Sizoo E. Health-related quality of life in high-grade glioma Taphoorn 2008 3


patients and their partners in the end-of-life phase

Nieuwenhuizen van D.

Quality of life and neurocognitive functioning in meningioma patients

Reijneveld 2008 1

Neurosurgery (VUmc)

Caretti V.* Brainstem tumors: development of anti-tumor drugs for convection enhanced delivery

Kaspers / Vandertop 2008 3

Hiddingh L. Development of preclinical pediatric brain tumor imaging models

Würdinger 2010 3

Nuclear Medicine and PET Research (Vumc)

Cheebsumon P.* Effects of image reconstruction, heterogeneity and F18-FDG kinetics on oncological response evaluation with PET

Boellaard / Smit 2008 3

Hoyng L.L. Quantitative imaging in cancer: connecting cellular processes with therapy: Data and Image Analysis (WP4)

Boellaard 2011 3

Makris N. PET methodology: quantification of long-lived PET tracers in oncology and immunology

Boellaard 2010 4

Langen, A.J. de* Evaluating therapeutic impact of induction therapy for locally advanced NSCLC with molecular imaging

Hoekstra 2005 1

Rizvi S.N. Qualifying imaging biomarkers for response evaluation in cancer

Hoekstra 2010 4

Veldt, A.A.M. van der*

PET imaging of [11C]docetaxel kinetics: part I, the role of bioavailability of [11C}docetaxel in predicting response

Hendrikse 2007 3

Nutricion and dietics (Vumc)

Buskermolen S. Prevalence and biomarkers of pre-cachexia and cachexia in advanced cancer patients scheduled for chemotherapy treatment

Verheul 2011 3

Oral and Maxillofacial Surgery and Pathology (Vumc)

Dekker H. Peri-implantitis, implan loss and radio-osteomyelitis in head and necktumor patients

Bloemena 2010 3

Orthopaedics (VUmc)

Posthuma de Boer J.

Treatment of osteosarcoma lung metastasis through targeted therapy

Kaspers / van Beusechem

2008 4

Otolaryngology / Head and Neck Surgery (VUmc)

de Boer D.V. Targeted therapy of precancerous fields in head and neck mucosa

Brakenhoff RH, Leemans CR

2012 3

Bruijn M. de Objective speech assessment in head and neck cancer: acoustic-phonetic and feature analyses by a neural network

Verdonck-de Leeuw 2008 3

Cnossen I.C. Prevention of speech, swallowing, and shoulder impairment after treatment for head and neck cancer


Cohen R. The selective targeting of angiogenesis and of tumour stroma

Van Dongen / de Bree / Leemans

2008 2

Flach G.B. The sentinel node procedure in head and neck cancer: clinical value and potential technical improvements

De Bree / Van Dongen

2007 3

Gogh van C.D.L. Voice therapy for patients with voice problems after treatment for early glottic cancer

Mahieu 2002 2

Lo Galbo A.M. Hypothyroidism after treatment for laryngeal cancer Leemans 2005 1

Heuveling D.H. Improvement of the sentinel node procedure in head and neck cancer by PET-CT lymfoscintigraphy

De Bree / Van Dongen

2008 4

Oskam I.M. Health related quality of life in head and neck cancer patients

Leemans 2004 1


Putten van der L. FDG-PET for avoidance of futile direct laryngoscopies under general anasthesia with taking of biopsies in patients

Leemans 2005 3

Rietbergen M. Clinical significance of human papillomavirus infection in oropharyngeal squamous cell carcinoma

Brakenhoff 2009 3

Schouten C.S. Response evaluation after chemoradiation for advanced oropharyngeal cancer using PET-CT and MRI

de Bree R 2012 2

Senft A. Screening for distant metastases and second primary tumors with FDG-PET (the school study)

Leemans 2002 2

Slobbe P. The development of radiolabeled tyrosine kinase inhibitors for PET imaging

Van Dongen 2011 3

Vosjan M.J.W.D.* Development of dual-specific nanobodies for cancer diagnosis and treatment

Van Dongen 2008 2

Pathology (VUmc)

Cordes M. Molecular biomarkers for the stratification of metastatic colorectal cancer patients

Meijer, Ylstra 2012 3

Dijkstra M.# Stratifying high-risk HPV positive women for risk of CIN 3 and cervical carcinoma by HPV transcript analysis

Snijders 2008 1

Goos J.A.C.M. Personalized therapy in recurrent colorectal cancer Hoekstra / Meijer 2009 3

Haan J.C. Prediction of response to drug therapy in advanced colorectal cancer based on DNA copy number profiles of primary tumors

Meijer / Ylstra 2007 3

Kocken M.# A retrospective longitudinal clinical cohort study to investigate HPV testing post-treatment and risk of recurrence of disease

Meijer 2008 3

Krijgsman O. Clinical and biological relevance of focal aberrations in colorectal cancer

Meijer 2008 3

Lubbers J. Genomic biomarkers to predict development of RA (VERA, ERA) and therapy responsiveness (ESRA)

Verweij 2011 3

Mollers M. HPV infections and immune status in a cohort of girls who are eligible for the national HPV immunisation

Meijer 2009 3

Ramayanti O. Epstein barr virus activation and cytolytic antivirual therapy in nasopharyngeal patients

Middeldorp 2011 3

Schütze D.M. Comprehensive analysis of the long-term oncogenic capacity and in vitro transforming property of the 15 high-risk human papillomavirus types (hrHPVs)

Snijders 2009 3

Snellenberg S. Development and clinical validation of a methylation marker set for the triage of hrHPV positive women

Snijders 2009 3

Strooper L. de Stratifying high-risk HPV positive women for risk of CIN 3 and cervical carcinoma by methylation analysis

Heideman 2010 3

Uijterwaal M. Simplified monitoring post-treatment CIN 2/3 women by molecular testing for hrHPV and methylationmarkers (SiMoNaTh)

Meijer 2010 3

Verhoef V. HPV self-sampling offered to screening non-attendees Meijer 2010 3

Verweij F.J. Involvement of EBV gene products in exosome-mediated tumor immune escape

Middeldorp 2009 3

Voorham Q.J.M. Increasing sensitivity for detection of high risk flat adenomas in population screening for colorectal cancer

Meijer 2006 3

Pediatrics (VUmc)

Bachas C. Characterization of relapsed acute myeloid leukaemia Cloos/ Schuurhuis 2007 1


Blufpand H.N. Carboplatin study: assessment and optimization of carboplatin exposure in pediatric oncology using different markers

Bökenkamp 2010 4

Braam K.I. Silicone gel sheet to improve cosmetic outcome of scar after removal of implantable central venous access device

Van Dulmen-den Broeder/Kaspers

2007 4

Franke N. Drug resistance in childhood leukemia Cloos / Kaspers 2006 4

Gordijn M.S. Dexamethasone and function of the HPA axis in children after treatment for Acute Lymphoblastic Leukemia

Kaspers 2011 3

Jansen M.H.A. Towards comprehensive therapy for diffuse intrinsic pontine gliomas in children

Kaspers 2009 4

Kors W.A. Retinoblastoma Cloos 2005 1

Krebber A.M.H. A stepped care programme in patients with high distress after treatment for head and neck cancer


Litsenburg, van R.*

ALL-10 treatment in acute lymphoblastic leukemia in children: a study into adjustment and quality of life

Kaspers 2006 1

Mir S.E. Therapeutic potential of histone deacetuylase inhibitors in the treatment of Medulloblastoma

Kaspers / Cloos 2007 2

Overbeek A. Reproductive function, ovarian reserve, and risk of premature menopause in female childhood cancer survivor

Voskuijl 2008 3

Veldhuijzen van Zanten S.E.M.

Drug distribution and local drug delivery in diffuse intrinsic pontine glioma

Kaspers, Vandertop 2012 3

Vuurden van D.G. Targeted therapy in pediatric brain tumors Kaspers 2005 1

Pulmonology (VUmc)

Lind J.* Management of advanced Non-Small Cell Lung Cancer: moving towards a more individualised approach

Smit 2007 3

Mellema W.W. New treatmentmodalities for lung cancer patients with a K-RAS mutation

Smit 2011 3

Phernambucq E. Multimodality treatment in NSCLC Smit 2008 3

Radiation oncology (VUmc)

Dahele M.R.* The implementation of advanced technologies in high-precision radiotherapy

Senan 2009 1

Narayan R.S. Targeting resistance to radio-chemotherapy by inhibition of the PI3Kinase-Akt signaling pathway

Slotman 2011 3

Tol J. Optimization and automation of radiotherapy treatment planning

Verbakel 2009 2

Radiology (VUmc)

Graaf de P.* Clinical and experimental high resolution ocular MR Imaging: towards improved detection of retinoblastoma tumor extent

Castelijns 2006 3

de Jong M.C. Multicenter implementation of MR imaging studies in children with retinoblastoma

Castelijns 2012 3

Rodjan F. Optimization of MR imaging studies in retinoblastoma patients

Castelijns 2010 3

Scheffer H.J. Evidence based interventional oncology: from last resort to potent alternative or additional treatment?

van Kuijk/ Meijerink 2012 1

Reumatology (VUmc)

Verbrugge C.S.E Proteasome inhibitor targeting of the immuno)proteasome: effects on immune effector cells

Dijkmans / Jansen 2008 1

Surgery (VUmc)


Ankersmit M. Photoimmunodetection of colorectal cancer Meijerink 2011 3

Nielsen K. Imaging and local treatment of colorectal liver metastasis Meijer, Comans 2011 3

De Cuba E. Peritoneal metastases from colorectal carcinoma; Diagnostic markers to identify patients thatbenefit from radical surgical resection

Bonjer 2010 1

Experimental Immunology (AMC/UvA)

Munneke J.M. T cell kinetics during immune reconstition after hematopoietic stem vcell transplantation

Van Oers/Hazenberg 2011 1

Gastro-enterology & Hepatology (AMC/UvA)

Barendse R. Treatment of large rectal adenomas Fockens/ Dekker 2009 2

Berg M.van den New endoscopic developments in GI oncology Fockens/van Hooft 2011

Denters M. Screening for CRC with repeated FOBT in the Netherlands Fockens / Dekker 2008 2

Van Doorn S. Diverse aspects of colorectal cancer screening Dekker 2011 2 and 4

Hazewinkel Y. Serrated polyposis syndrome: endoscopic treatment and surveillance of patients and screening of first-degree relatives

Dekker 2010 3

Jong K. de* Cystic neoplasms of the pancreas Fockens/Bruno 2008

Kuiper T. Advanced colonoscopic imaging Fockens/ Dekker 2009 4

Stegeman I. Risk-profiling in CRC-screening Dekker 2009 2

Verlaan T. Transmural endoscopy Fockens/Bemelman 2010

Wanders L. Advanced colonoscopic imaging Dekker 2011 2 and 4

Wijkerslooth T. de Population screening for colorectal cancer by colonoscopy or CT-colonography in the Netherlands

Fockens / Bossuyt/Dekker

2008 2

Human Genetics (AMC/UvA)

Santo E.E. FOX03 in neuroblastoma Koster/ Versteeg 2007 1

Medical Oncology (AMC/UvA)

Kleinjan A. Cancer and (anti)coagulation Buller / Kamphuisen / Richel

2010 1

Obstetrics and Gynaecology (AMC/UvA)

Rutten M.J. Laparoscopy instead of prediction of primary debulkin of ovarium carcinoma

Kenter / Buist 2010 1 and 3

Pediatric Oncology (AMC/UvA)

Dijk van I.W.E.M. Late effects of radiotherapy in childhood cancer survivors Caron / Koning / Kremer

2010 3

Eijkelenburg van N.

Ealry phase medication studies for childhood cancer Caron / Verschuur 2007 3

Knijnenburg S. Website aimed at childhood cancer survivors Jaspers / Kremer 2007 3

Knops R.R.G. Quality care in paediatric oncology Hulscher/Kremer 2009 3

Mulder R. Late effects of childhood cancer survivors Caron / Kremer 2008 3

Sieswerda E. new drug development, clinical trials and late effects Caron/ Kremer 2007 3

Psychosocial department (UvA/AMC)

Aukema E.J. Late consequences and needs of young survivors of a brain tumor and their parents

Grootenhuis Last/Schouten/

2006 1

Schepers S.A. Living with chldhood cancer Grootenhuis/Verhaak 2011 3

Sint Nicolaas S. Living with chldhood cancer Grootenhuis/Prins/ Verhaak

2011 3

Ruiter de M. Pediatric research on improving speed, memory and attention

Grootenhuis / Caron / Oosterlaan/ Schouten

2008 3


Radiotherapy (UvA/AMC)

Balidemaj E. Improved regional hyperthermia delivery using hyperthermia treatment planning based on MRI data

Rasch/Crezee 2010 3

Chai X.F.* High precision image-guided radiotherapy for bladder cancer

van Herk/ Hulshof/ Bel

2007 3

Dinkla A. Brachytherapy treatment planning: optimisation and evaluation

Rasch / Bel 2010 1 and 4

Greef de M.* Optimisation of regional hyperthermia delivery using a newly developed 3-D hyperthermia system

Crezee / Kok 2010 3

Hamming O. Dose redistribution in the presence of anatomical changes in head and neck cancer

Verheij/Rasch 2011

van Oorschot B. Investigation of a gene set classifier for late radiation toxicity in prostate cancer patients

Medema / Franken 2010 3

Oei, A Towards biological treatment planning in radiotherapy combined with hyperthermia to improve clinical outcome

Franken / Kok 2012 3

Rooijen van D.* Image-guided radiotherapy using CBCT and advanced treatment planning

Koning/ Bel 2006 4

Schooneveldt G. Optimization of bladder hyperthermia treatment for NMIBC by using loco-regional heating, improved 3-D thermometry

Crezee/Hulshof 2012 3

Van Leeuwen C Towards biological treatment planning in radiotherapy combined with hyperthermia to improve clinical outcome

Kok/Franken/Stalpers 2012 3

Urology (AMC/UvA)

Barwari K.* Renal cell carcinoma De la Rosette/ Laguna

2009

Beemster P. Cryosurgery of small renal tumors De la Rosette/ Laguna/ Wijkstra

2005 1

Smeenge M. Imaging in Urology De la Rosette/ Laguna

2009


awards

Awards - 47

5. Awards This chapter lists awards and honors won by staff and students involved in OOA throughout 2012. The lists are in alphabetical order of the recipients’ last name. Faculty and staff members of the OOA fulfilled numerous functions in national and international organizations, on scientific boards of scientific journals, as members of study sections, and as organizers or co-organizers of scientific meetings, workshops and congresses. H. Albers won the Dutch ‘Farmacochemieprijs’ 2011-2012 A. Avan received the VUmc CCA Scholarship for PhD education. R. Bernards received the ‘Koningin Wilhelmina Onderzoeksprijs’ of 2 milion euro to elaborate research on ‘Finding genetic dependencies in cancer: the missing link in personalized medicine’. A. Berns was awarded the honor of ‘Ridder in de orde van de Nederlandse Leeuw’ J. Bretschneider was nominated as one of the six most innovative educators of the world on the Apple Education Conference 2012 J. Dekker was appointed as honorary professor on de Jining Medical University, Jining, China C. Fedrigo received the travel Award from the European Association of Neuro Oncology S. Gibbs and G. Limandjaja won the poster prize (300 euro) at the European Tissue Repair Society Meeting in Athens, Greece. E. Giovannetti won the Berlucchi Award for Young Italian Researchers and the young Researcher Travel grant 2012. She also received an invitation to the Early Career Investigators platform kick-off meeting “EORTC ECI platform” S. Huang received the ‘Antoni van Leeuwenhoekprijs 2012’ of 6,500 euro . He is rewarded with this price thanks to his work on the mechanisms underlying anticancer therapy resistance. W. Kamphorst was awarded the honor of ‘Officier in de Orde van Oranje-Nassau’. C. Leemans was pronounced as Helmuth Goepfert Distinguished Visiting Professor at the M.D.

Anderson Cancer Center, Department of Head and Neck Surgery, Houston, TX, USA M. Maftouh received the VU Fellowship. C. Mulder was awarded as honorary and distinguished fellow of the Royal College of Physicians R. Scheper was awarded the honor of ‘Ridder in de Orde van Oranje-Nassau’ I. van der Waal was awarded as Honorary Member of the Scandinavian Society of Oral Pathology and Oral Medicine A. van Furth received the honor of associate professor extraordinary: paediatrics and child health S. Veldhuijzen van Zanten won the Best presentation price at the Nederlandse Vereniging voor Kindergeneeskunde (NVK) Congres S. Veringa won the Nijbakker Morra prijs

48 - Awards


faculty and staff

annex

Faculty and staff - 51

Annex 1. Faculty and staff of OOA FACULTY Prof. dr. N.K. Aaronson, Department of Psychosocial Research and Epidemiology, NKI (Theme 2). (1) health-related quality of life (HRQL) assessment in clinical research and clinical practice; (2) symptom perception and management; and (3) psychosocial issues in cancer clinical genetics. Dr. R. Agami, Department of Gene Regulation, NKI (Theme 1). MicroRNAs in cancer. Dr. J.A. Aten, Department of Cell Biology and Histology, AMC (Theme 1). Interactions of DNA double strand breaks and repair proteins in the formation of chromosome translocations and cell killing by ionizing radiation and other therapeutic agents. Dr. R. Beijersbergen, Department of Molecular Carcinogenesis, NKI (Theme 1). The RNAi strategy in target discovery Prof. dr. R. Bernards, Department of Molecular Carcinogenesis, NKI (Theme 1). Functional genomics Prof. dr. A.J.M. Berns, Department of Molecular Genetics, NKI (Theme 1). Mouse models for cancer Prof. dr. J.H. Beijnen, Division of Pharmacology, NKI (Theme 2). Clinical pharmacology of anticancer drugs Dr. C.U. Blank, Department of Immunology, NKI (Theme 1 and 2). Combating tumor immune escape Prof. dr. E. Bloemena, Department of Pathology, VUmc (Theme 1 and 2). Molecular profiling of head & neck tumors Prof. dr. J.G. Borst, Department of Immunology, NKI (Theme 1). Lymphocyte activation and survival Prof. dr. P. Borst, Department of Molecular Oncology, NKI (Theme 1). DNA base J / Multidrug resistance of cancer cells / Drug resistance Prof. dr. E. Boven, Department of Medical Oncology, VUmc (Theme 2). Kinase inhibitors in renal cancer

Prof. dr. R.H. Brakenhoff, Department of Otolaryngology-Head & Neck Surgery, VUmc (Theme 1 and 2). Molecular mechanisms in precursor lesions and early stages of head & neck cancer for early detection Prof. dr. R. de Bree, Department of Otolaryngology-Head & Neck Surgery, VUmc (Theme 1 and 2). Molecular mechanisms in precursor lesions and early stages of head & neck cancer for early detection Prof. dr. H. N. Caron, Paediatric Oncology, AMC (Theme 1 and 2). Paediatric Oncology: new drug development, clinical trials and late effects Prof. dr. J.A. Castelijns, Department of Radiology, VUmc (Theme 2). Imaging in head and neck cancer Dr. J. Crezee, Department of Radiation Oncology, AMC (Theme 2). New hyperthermia techniques and development and application of hyperthermia treatment planning. Prof. dr. G.A.M.S. van Dongen, Department of Otolaryngology-Head & Neck Surgery, VUmc (Theme 1 and 2). Molecular imaging of cancer for diagnosis in therapy selection with a focus on PET Dr. E.F. Eldering, Department of Experimental Immunology, AMC (Theme 1). Apoptosis regulation in immuno-hematology. Dr. D. Geerts, Department of Human Genetics, AMC (Theme 1). Developmental genes in neuroblastoma pathogenesis Prof. dr. D.J. Gouma, Department of Surgery, AMC (Theme 2). Development and optimalization of treatment modalities for pancreatic cancer patients Prof. dr. A.W. Griffioen, Department of Medical Oncology, VUmc (Theme 2). Tumor angiogenesis and drug therapy Dr. M. A. Grootenhuis, Department of Pediatrics, AMC (Theme 2). Psychosocial consequences of childhood cancer

52 – Faculty and staff

Prof. dr. T.M. van Gulik, Department of Experimental Surgery, AMC (Theme 2). Experimental surgery on colon cancer liver metastases Prof. dr. A. Hagenbeek, Department of Hematology, AMC (Theme 1 and 2). 1. Phase I, II and III clinical trials in the non-Hodgkin lymphomas (NHL) and 2.Suicide gene therapy Dr. J. Haanen, Department of Medical Oncology, NKI (Theme 1 and 2). Immunotherapy Dr. S.M. van Ham, Department of Immunology, AMC (Theme 1 and 2). 1. Antigen presentation in leukemias. 2. Dendritic cell immunotherapy in cancer. Prof. dr. J.J. Heimans, Department of Neurology, VUmc (Theme 1). miRNAs regulating angiogenesis in gliomas Prof. Dr. M. van Herk, Department of Radiotherapy, NKI (Theme 2). Radiotherapy: Image acquisition and processing Prof. dr. O.S. Hoekstra, Department of Nuclear Medicine, VUmc (Theme 2). Molecular imaging using PET for therapy selection and response monitoring Prof. dr. P.C. Huijgens, Department of Haematology, VUmc (Theme 1 and 2). Targetted therapies in myeloid leukemia Dr. T.J.M. Hulsebos, Department of Neurogenetics, AMC (Theme 1). Molecular genetics of nervous system tumors and osteosarcomas Dr. K. Jalink, Department of Cell Biology, NKI (Theme 1). Biophysics of cell signaling Dr. J. Jonkers, Department of Molecular Biology, NKI (Theme 1). Mouse models of breast cancer Prof. dr. G.J. Kaspers, Department of Paediatrics, VUmc (Theme 2). Innovative therapies in childhood myeloid leukemia Prof. dr. G.G. Kenter, Department of Obstetrics and Gynaecology, AMC/VUmc/NKI (Theme 2). Immunosurveillance and Immunotherapy in HPV related tumours and late complications after treatment for carcinoma of the cervix. Prof. dr. Y. van Kooyk, Department of Molecular Biology and Immunology, VUmc (Theme 1 and 2). Glycosilation and tumor immunology Dr. K.K. Krishnadath, Department of Gastroenterology and Hepatology, AMC (Theme 1). Understanding the inflammation-dysplasia-carcinoma sequence within the gastrointestinal tract

Dr. A.B.P. van Kuilenburg, Department of Clinical Chemistry, AMC (Theme 1 and 2). Inborn errors of purine and pyrimidine metabolism and paediatric oncological diseases Prof. dr. A.A. Lammertsma, Department of Nuclear Medicine, VUmc (Theme 2). Standardization and quantification of PET image analysis Prof. dr. Ch.R. Leemans, Department of Otolaryngology-Head & Neck Surgery, VUmc (Theme 2). Molecular mechanisms in precursor lesions and early stages of head & neck cancer for early detection Prof. dr. A.G.J.M. van Leeuwen, LaserCenter, AMC (Theme 2). Biomedical photonics for functional and molecular imaging Prof. dr. F.E. van Leeuwen, Psychosocial Research and Epidemiology, NKI (Theme 2). Epidemiology Dr. F. van Leeuwen, Department of Cellular Biochemistry, NKI (Theme 1). Epigenetic regulation of gene expression Dr. S. Linn, Department of Molecular Pathology, NKI (Theme 2). Molecular dissection of breast and lung cancer by differential drug sensitivity Prof. dr. M. van Lohuizen, Department of Molecular Genetics, NKI (Theme 1). Role of polycomb-group genes in transcriptional repression and stem cell fate Dr. R.M. Luiten, Department of Dermatology, AMC (Theme 2). Immunology of melanoma and autoimmune or inflammatory skin diseases Prof. dr. J.P. Medema, Laboratory of Experimental Oncology and Radiobiology, AMC (Theme 1). Cell death induction and resistance in tumor cells and cancer stem cells Prof. dr. C.J.L.M. Meijer, Department of Pathology, VUmc (Theme 1 and 2). HPV based early detection of cervical cancer precursors Prof. dr. G.A. Meijer, Department of Pathology, VUmc (Theme 1 and 2). Molecular classification for early detection and personalized therapy in gastrointestinal (colon, gastric) cancer Prof. dr. H. Meijers-Heijboer, Department of Clinical Genetics, VUmc (Theme 1). Genetic cancer predisposition with a focus on breast cancer Dr. J.J. Molenaar, Department of Oncogenomics, AMC (Theme 1) . Targeted drug development in neuroblastoma


Prof. dr. W.H. Moolenaar, Department of Cell Biology, NKI (Theme 1). Lipid growth factor signaling Prof. dr. J.M. Middeldorp, Department of Pathology, VUmc (Theme 1 and 2). EBV associated carcinogenesis and early detection Prof. dr. C.J.J Mulder, Department of Gastro-enterology and hepatology (Theme 2). Celiac disease associated lymphomagenesis Prof. dr. J.J.C. Neefjes, Department of Cell Biology, NKI (Theme 1). Antigen presentation by MHC class I and MHC class II molecules Prof. dr. C.J.M. van Noesel, Department of Pathology, AMC (Theme 1). B cell biology and the pathogenesis of B-NHL / The serrated neoplasia pathway to colorectal cancer Prof. dr. M.H.J. van Oers, Department of Hematology, AMC (Theme 1 and 2). Pathogenesis and Immunotherapy of B cell malignancies Prof. dr. C.J.F. van Noorden, Department of Pathology, AMC (Theme 1). Proteases and protease inhibitors in cancer Prof. dr. G.J. Ossenkoppele, Department of Haematology, VUmc (Theme 1 and 2). Targetted therapies in myeloid leukemia Dr. H. Ovaa, Department of Cell Biology, NKI (Theme 1). Chemistry and biology of proteolysis and antigen presentation Prof. dr. S.T. Pals, Department of Pathology, AMC (Theme 1 and 2). Molecular pathogenesis of B cell malignancies and the role of heparan sulfates proteoglycans in tumorigenesis Dr. A. Perrakis, Department of Biochemistry, NKI (Theme 1). Structural biology and structural biology methods Dr. D. Peeper, Department of Molecular Oncology. NKI (Theme 1). Resolving cancer cell networks and identifying cancer drug targets Prof.dr. G.J. Peters, Department of Clinical Oncology, VUmc (Theme 2). Pharmacokinetics and response prediction in oncology Prof. dr. P.J. Peters, Department of Cell Biology, NKI (Theme 1). Nanobiology Prof. dr. P. Postmus, Department of Pulmonology, VUmc (Theme 2). Targetted drug therapy in lung cancer Prof. dr. D.J. Richel, Department of Medical Oncology, AMC (Theme 1 and 2). New chemotherapeutic avenues for neoadjuvant and adjuvant treatment of cancer patients

Prof. dr. H.P.J. te Riele, Department of Biological Stress Response, NKI (Theme 1). DNA mismatch repair / The Fanconi anemia pathway / cell cycle checkpoints Prof. dr. S. Rodenhuis, Department of Molecular Pathology, NKI (Theme 2). Breast cancer therapy and prediction of response Prof. dr. J.J.M.C.H. de la Rosette, Department of Urology, AMC (Theme 2). Improving diagnosis and treatment of Urological cancers Prof. dr. J.H.M. Schellens, Department of Molecular Pathology, NKI (Theme 2). Clinical pharmacology of anticancer drugs Dr. A. Schinkel, Department of Molecular Oncology, NKI (Theme 1). Genes and proteins involved in anti cancer drug resistance and pharmacokinetics Prof. dr. T. Schumacher, Department of Immunology, NKI (Theme 1). Dissection of virus- and tumor-specific T cell immunity Dr. G.J. Schuurhuis, Department of Hematology, VUmc (Theme 2). Disease profiling CML and AMC Prof. dr. S. Senan, Department of Radiation Oncology, VUmc (Theme 2). Technological innovations in applied radiotherapy Prof. dr. T.K. Sixma, Department of Biochemistry, NKI (Theme 1). Structural biology of proteins involved in ubiquitin conjugation in chromatin regulation, DNA mismatch repair and nicotinic receptor signaling. Prof. dr. B.J. Slotman, Department of Radiation Oncology, VUmc (Theme 1 and 2). Technological innovations in applied radiotherapy Prof. dr. E.F. Smit, Department of Pulmonology, VUmc (Theme 2). Targetted drug therapy in lung cancer Dr. A. Sonnenberg, Department of Cell Biology, NKI (Theme 1). Receptors for matrix adhesion Dr. M. Spaargaren, Department of Pathology, AMC (Theme 1). Explore the molecular and functional aspects of: (1) chemokine- and B cell antigen receptor-signaling; (2) HGF/MET- and WNT-signaling; and (3) heparan sulfate proteoglycans (i.e., CD44v3 and Syndecan-1) and their modifying enzymes. Dr. C.A. Spek, Department of Experimental and Molecular Medicine, AMC (Theme 1 and 2). Blood coagulation in pathophysiology


Dr. B. van Steensel, Department of Gene Regulation, NKI (Theme1). Chromation genomics Prof. dr. M.J.B. Taphoorn, Department of Neurology, VUmc (Theme 2). Quality of life in neurooncology Prof. dr. I.M. Verdonck- de Leeuw, Department of Otolaryngology/Head and Neck Surgery, VUmc (Theme 2). Innovative care programs in oncology Dr. M. Verheij, Department of Radiotherapy, NKI (Theme 2). Mechanisms, modulation and prediction of radiation-induced cell death Prof.dr. H.W.M Verheul, Department of Medical Oncology, VUmc (Theme 1 and 2). Angiogenesis and phosphokinase as drug targets in gastrointestinal and renal cancer Prof. dr. R. Versteeg, Department of Human Genetics, AMC (Theme 1 and 2). Regulatory networks in cancer Prof. dr. M. van de Vijver, AMC (Theme 2). Genetic alterations and gene expression profiles of solid tumors

Dr. H. Wijkstra, Department of Urology, AMC (Theme 2). Minimal invasive technology in diagnoses, therapy and follow-up of uro-oncology Dr. T. Wurdinger, Department of Neurosurgery (Theme 1). miRNAs regulating angiogenesis in gliomas


STAFF

Netherlands Cancer Institute Cell Biology Dr. J.G. Collard Dr. M.E. Innocenti Dr. C. Jalink Dr. R.J.A.M. Michalides Prof.dr. W.H. Moolenaar Prof.dr. J.J. Neefjes Prof.dr. P.J. Peters Dr. H. Ovaa Dr. E. Roos Dr. A. Sonnenberg Molecular Carcinogenesis Prof.dr. R. Bernards Dr. R. Beijersbergen Dr. R. Wolthuis Biochemistry Dr. T. Brummelkamp Dr. S. Mukherjee Dr. A. Perrakis Prof.dr. T.K. Sixma Gene Regulation Dr. R. Agami Dr. J-H. Dannenberg Dr. F. van Leeuwen Prof.dr. B. van Steensel Immunology Dr. C.H. Blank Prof.dr. J. Borst Dr. J.B.A.G. Haanen Dr. H. Jacobs Prof.dr. T.N.M. Schumacher Molecular Biology Prof.dr. P. Borst (honorary staff member) Dr. J. Jonkers Dr. S. Linn Dr. H. van Luenen Prof.dr. H. te Riele Prof.dr.A.Schinkel Dr. L. Wessels Molecular Genetics Prof.dr. A.J.M. Berns Dr. A.P. Haramis Dr. J. Hilkens Dr. J.J.L. Jacobs Prof.dr. M. van Lohuizen Dr. P.S. Peeper Experimental therapy Prof.dr. J.H.M. Schellens Dr. M. Schmidt Dr. F.A. Stewart Dr. M. Verheij Prof.dr J. Wesseling Dr. W. Zwart Radiotherapy B.M.P. Aleman Prof.dr. G.M.M.. Bartelink Dr. J.S.A. Belderbos Dr. M. Bloemers Dr. G. Borst Dr. R.W. de Boer Dr. L.G.H. Dewit J. van Diesen

Dr. P. Elkhuizen Dr. R.L.M. Haas O. Hamming-Vrieze Dr. W. Heemsbergen Prof.dr. M. van Herk Dr. E.P.M. Jansen J. Knegjens H. Krewinkel Dr. J. Lebesque Dr. B.J. Mijnheer Dr. L.M.F. Moonen A. Navran H. Peulen Dr. F. Pos Dr. C.R.N. Rasch B. Reichgelt Dr. P. Remeijer Dr. N.S. Russell J.G. Salverda Dr. C.Schneider Dr. J-J. Sonke Dr. J. Stroom Dr. B. van Triest Dr. C. van Vliet-Vroegindeweij Dr. T. Witteveen Dr. F.W. Wittkämper Medical Oncology Dr. J.W. Baars Dr. P. Baas Dr. A. Bergman Prof.dr. J.H. Beijnen Dr. C. Blank Dr. J.P. de Boer Dr. W. Boogerd Dr. H. Boot Dr. D. Brandsma Dr. E. Brouwers Dr. W. Buikhuizen Dr. J.A.. Burgers Dr. A. Cats Dr. J.B.A.G. Haanen Dr. M van den Heuvel Dr. A. Huitema Dr. J.M. Kerst M. van Leerdam Dr. S.C. Linn Dr. A. Lukas S. Marchetti Prof.dr. S. Rodenhuis Prof.dr. J.H.M. Schellens G. Sonke J. Stouthard Dr. N. Steeghs Dr. B.G. Taal M Tesselaar Dr. M. van der Weide. Surgical Oncology A. Aalbers Dr. K. Ariese Dr. M-J. Baas-Vracken Peters M. van der Berg Dr. M. Van Beurden Dr. A. Bex Dr. M.W.M. van den Brekel D.R. Buitelaar J. ten Cate Dr. F. van Coevorden Dr. M. Crijns


Dr. B. Drost K. Efthymiou Dr. J.J. Hage Dr. J. van der Hage Dr. C. Hahn D. Hompes Prof.dr. S. Horenblas S. Huissoon M. van Huizum L. Hulshoff Dr. H. Klomp Dr. R. Meijer Dr. W. Meinhardt I. Nieuweboer-Krobotova Dr. O.E. Nieweg Dr. H.S.A. Oldenburg K. Peeters M. Piek-Hartog Dr. H.G. van de Poel Dr. G. Relyveld B. van Rhijn Dr. T. Ruers Dr. E.J.Th. Rutgers Dr. J. van Sandick P.F.E. Schutte Dr. M. Scrámek Dr. W. Van der Veen I. Vergouwe Dr. V.J. Verwaal Dr. L.A.E. Woerdeman M. Wouters B. Zupan-Kajcovski Psychosocial Research and Epidemiology Prof.dr. N.K. Aaronson Dr. E. Bleiker Prof.dr. W.J. van Harten Dr. M.Hauptmann Prof.dr. F.E. van Leeuwen Dr. M.A. Rookus Dr. S. Schagen Dr. M. Schmidt Diagnostic Oncology Dr. P. Axwijk P. Baars Dr. O. Balague Ponz A.P.E. Besnard Dr. H. van Boven Dr. A. Broeks Dr. A. Bruining Dr. K. Gilhuijs

Dr. B. Heeres Dr. S. Heijmink Dr. C.A. Hoefnagel Dr. D. de Jong J. de Jong Dr. J. Kluijt P. de Koekkoek-Doll W. Koops Dr. L. Van der Kolk Dr. T. Korse Dr. R. Kröger C. Lange Dr. F.van Leeuwen C. Loo Dr S.H. Muller Dr. J. Muris Dr. P.M. Nederlof Dr. W.J. Nooijen Dr. R. van Pel Dr. P. Pevenage W. Prevoo Dr. E. Rosenberg Dr. M. Ruijs Dr. J. Sanders Dr. M. Sinaasappel Dr. F. Sivro Dr. M. Stokkel Dr. J. Teertstra Dr. O. van Tellingen Dr. R.A. Valdès Olmos Dr. E. Vegt Dr. M.L.F. van Velthuijsen Dr. S. Verhoef Dr. W. Vogel Dr. J. Wesseling Dr. I. Westerveld - de Zwart Dr. B. van der Wiel Dr. G. Winter-Warnars Dr. A. Yazdi


VU University Medical Center Anesthesiology Dr. R.S.G.M. Perez Prof.dr. W.W.A. Zuurmond Clinical Chemistry Prof.dr. M.A. Blankenstein Dr. C.B.M. Oudejans Clinical Genetics Dr. J.C. Dorsman Dr. J.J.P. Gille Dr. L.P. van Hest Prof.dr. H. Joenje Prof.dr. H.E. Meijers-Heijboer Dr. F.H. Menko Dr. Q. Waisfisz Dr. J.P. de Winter Gastroenterology Dr. A.A. van Bodegraven Dr. R.J.F. Felt-Bersma Prof.dr. C.J.J. Mulder Dr. C.M.J. van Nieuwkerk

Hematology Dr. J.M. Baalbergen Dr. M.E.D. Chamuleau Dr. J. Cloos Dr. A.M. Dräger Prof.dr. P.C. Huijgens Dr. D.E. Issa Dr. J.J.W.M. Janssen Dr. A.A. van de Loosdrecht Prof.dr. G.J. Ossenkoppele Dr. G.J. Schuurhuis Dr. N. Thielen Dr. O. Visser Dr. J.M. Zijlstra Dr. S. Zweegman Medical Oncology Dr. V.W. van Beusechem Prof.dr. E. Boven Dr. H.J. Broxterman Dr. J. Buter Dr. A.J.M. van den Eertwegh Prof.dr. W.R. Gerritsen Prof.dr. A.W. Griffioen Dr. T.D. de Gruijl Dr. C.W. van der Houven van Oordt Dr. C.R. Jimenez Dr. I.R.H.M. Konings Dr. M.E. van Linde Prof.dr. G.J. Peters Prof.dr. H. Verheul Dr. J.J. van der Vliet Dr. M.J.D.L. van der Vorst Medical Psychology Prof.dr. P.T. Cohen-Kettenis Dr. J. Huisman Dr. M. Klein Molecular Celbiology and Immunology Prof.dr. R.H.J. Beelen Prof.dr. G. Kraal Prof.dr. R.E. Mebius

Nefrology Dr. C.E. Douma Dr. K. Farhat Dr. S.A. Nurmohamed Dr. C.Y. le Poole Dr. J.W. Rüger Neurology Prof.dr. J.J. Heimans Dr. T.J. Postma Dr. J.C. Reijneveld Prof.dr. M.J.B. Taphoorn Neurosurgery Dr. J.C. Baayen Dr. R.E. Feller Dr. D.P. Noske Dr. S.M. Peerdeman Prof.dr. W.P. Vandertop Dr. P.C. de Will Hamer Dr. T. Würdinger Nuclear Medicine and PET Research Dr. R. Boellaard Prof.dr. E.F.I. Comans Dr. J.D.M. Herscheid Prof.dr. O.S. Hoekstra Prof.dr. A.A. Lammertsma Dr. C.F.M. Molthoff Dr. P.G. Raijmakers Dr. A. van Schie Dr. G.W.M. Visser Dr. A.D. Windhorst Obstetrics and Gynaecology Prof.dr. G. Kenter Opthalmonology Dr. A.C. Moll Oral and Maxillofacial Surgery and Pathology Prof.dr. E. Bloemena Dr. E.A.J.M. Schulten Dr. K.H. Karagozoglu Dr. D. Hertog Prof.dr. I. van der Waal Otolaryngology/Head and Neck Surgery Dr. B.M. Braakhuis Prof.dr. R.H. Brakenhoff Prof.dr. R. de Bree Prof.dr. G.A.M.S. van Dongen Dr. S.J. Erenstein-Kraay Prof.dr. J.M. Festen Prof.dr. C.R. Leemans Dr. R.N.P.M. Rinkel Prof.dr. I.M. Verdonck-de Leeuw Dr. S. van Weert Paediatrics Dr. J. Cloos Prof.dr. A.M. van Furth Prof.dr. G.J.L. Kaspers Dr. M.F. Mulder Dr. N.A. Oeij Dr. R.N. van der Plas Prof.dr. A.J.P. Veerman


Pathology Dr. J.A.M. Beliën Dr. M.C.G. Bleeker Prof.dr. E. Bloemena Dr. B.M.E. von Blomberg Dr. B. Carvalho Dr. S.A.G.M. Cillessen Prof.dr. P.J. van den Elsen Dr. F.J.A. Fijneman Dr. N.C. van Grieken Dr. A.H. van Hattum Dr. E. Hooijberg Dr. F. van Kemenade Prof.dr. C.J.L.M. Meijer Prof.dr. G.A. Meijer Prof.dr. J.M. Middeldorp Prof.dr. W.J. Mooi Dr. S.A. Morré Dr. L. Rozendaal Prof.dr. R.J. Scheper Prof.dr. P.J.F. Snijders Dr. R.D.M. Steenbergen Dr. F.B.J.M. Thunnissen Prof.dr. P. Wesseling Prof.dr. C.L. Verweij Dr. B. Ylstra Pulmonology Dr. I. Bahce Dr. A. Becker Dr. J.M.A. Daniels

Dr. S.M.S. Hashemi Prof.dr. P.E. Postmus Prof.dr. E.F. Smit Dr. T.G. Sutedja Radiation Oncology Dr. M.R. Dahele Dr. P. Doornaert Dr. C.J. Haasbeek Dr. M.V.M. Lafleur Dr. F.J. Lagerwaard Prof.dr. S. Senan Prof.dr. B.J. Slotman Dr. P. Sminia Radiology Prof.dr. J.A. Castelijns Surgery Prof.dr. J.J. Bonjer Prof.dr. M.A. Cuesta Dr. M. Van Egmond Prof.dr. S. Meijer Dr. M.P. van den Tol Dr. L. te Velde Urology Dr. A.A. Geldof Prof.dr. R.J.A. van Moorselaar Dr. A. Vis


University of Amsterdam Biomedical Engineering and Physics Dr.ir. G.J. Streekstra Cell Biology & Histology Dr. J.A. Aten Prof.dr. C.J.F. van Noorden Dermatology Dr. R.M. Luiten Experimental Internal Medicine Dr. C.A. Spek Gastroenterology & Hepatology Dr. E. Dekker Prof. dr. P. Fockens Dr. K.K. Krishnadath Genetic Metabolic Diseases Dr. A.B.P. van Kuilenburg Human Genetics Dr. H.A.M. Geerts Dr. M. Kool Dr. L.J. Valentijn Prof.dr. R. Versteeg Hematology Prof. dr. A. Hagenbeek Dr. A.P. Kater Dr. M.J. Kersten Prof. dr. M.H.J. van Oers Immunology Dr. E.F. Eldering LaserCenter Prof.dr. A.G.J.M. van Leeuwen Medical Bioinformatics Prof. dr. A.H.C. van Kampen Medical Oncology Prof.dr. D.J. Richel Neurogenetics Dr. T.J.M. Hulsebos Obstetrics and Gynaecology Prof. dr. G.G. Kenter Paediatric Oncology Prof.dr. H.N. Caron Dr. M.A. Grootenhuis Prof. dr. L.C.M. Kremer Dr. A.B.P. van Kuilenburg Pathology Prof. dr. C.J.M. van Noesel Prof.dr. S.T. Pals Dr. M. Spaargaren Prof. dr. M.J. van de Vijver

Radiotherapy Dr. J. Crezee Dr. N.A.P. Franken Prof.dr. C.C.E. Koning Prof.dr. J.P. Medema Dr. L.J.A. Stalpers Prof. dr. C.R.N. Rasch Urology Prof.dr. J.J.M.C.H. de la Rosette Prof.dr.ir. H. Wijkstra


international visitors

annex

International visitors - 63

Annex 2. International visitors Albers C., United Kingdom Alexis M., Greece Aplenc R., USA Baietti F., Belgium Busch D., Gemany Carrard V.C., Brasil Del Chiaro M, Sweden Church S., USA Dixit V., USA Durocher D., Canada Enders A., Australia Ganesan S., USA Gardner R., USA Gilbert N., UK Goldberg A., USA Groettrup M., Germany Haimovitz-Friedman A., USA van Heijst J., USA Hemann M., USA Higgins J., USA Kallioniemi O., Finland Kzhykowska, Germany de Lange T., USA Lingner J. Switzerland McDermott U., UK Mellman I., USA Muir T., USA Nurse P., UK Nusse R., USA Ohno H., Japan Pepperkok R., Germany Pedreira Collazo E., Urugauy Piccolo S., Italy Premsrirut P., USA Ram P., USA Ramaswamy S., USA Reid G., Australia Ries C., Germany Rodriguez J., Spain

del Sal G., Italy Martien van Santen H., Spain Scita G., Italy Schmitt C., Germany Segersvärd R., Sweden Sicinski P., USA So E., UK Spellman P., USA Sperling R., Israel Suter, Swiss Swanton C., UK Walter J., USA Wutz A., UK Yewdell J., USA Zender L., Germany Zuber J., Vienna, Austria

64 – International visitors


PhD theses completed

annex

PhD theses completed – 67

Annex 3. PhD Theses completed In 2012, 40 graduate students completed their graduate training and obtained a PhD degree. Their names, thesis titles, supervisors and institutes are listed below. The institute at which the research described in the theses was carried out is mentioned between brackets and may differ from the university where the PhD graduation took place. Name : Albers, H. (NKI) Title : Development of ATX and DUSP inhibitors: Inhibiting phosphate ester hydrolysis in

biology University : University Leiden (co)Promotors : Neefjes, J.J. Date : 4-4-2012 Name : Barwari, K. (AMC) Title : Renal tumor ablation: beyond limitations of biopsy and follow-up University : University of Amsterdam (co)Promotors : de la Rosette J.J.M.C.H., Laguna Pes M.P., Wijkstra H. Date : 18-12-2012 Name : van Bemmel, J. (NKI) Title : Chromatin Flavors: Chromatin Composition and Domain Organization in Drosophila

melanogaster University : University Rotterdam (co)Promotors : Van Steensel, B. Date : 9-5-2012 Name : Bunt J. (AMC) Title : The role of OTX2 in medulloblastoma University : University of Amsterdam (co)Promotors : Versteeg R., Kool M. Date : 27/11/2012 Name: : Caretti V. (VUmc) Title: : Pioneering Preclinical Research in Diffuse Intrinsic Pontine Glioma: Towards New

Treatment Strategies University: : Vrije Universiteit Amsterdam (co)Promotors: : Kaspers G.J.L., Vandertop W.P., Wurdinger T., Noske D.P. Date: : 7/3/2012 Name : Chai X. (AMC) Title : Building tools for image-guided adaptive radiotherapy of bladder cancer University : University of Amsterdam (co)Promotors : van Herk M.B., Koning C.C.E., Bel A. Date : 07/06/2012 Name: : Cheebsumon P. (VUmc) Title: : Quantification and Tumor Delineation in PET University: : Vrije Universiteit Amsterdam (co)Promotors: : Lammertsma A.A., Boellaard R., van Velden F.H.P. Date: : 2/15/2012

68 - PhD theses completed

Name: : Dahele M.R. (VUmc) Title: : The implementation of advanced technologies in high-precision radiotherapy. University: : Vrije Universiteit Amsterdam (co)Promotors: : Senan S., Slotman B.J. Date: : 11/21/2012 Name : Drost, J. (NKI) Title : Identifying novel components of human tumour suppressor networks University : University Rotterdam (co)Promotors : Agami, R. Date : 28-3-2012 Name : Drost, R. (NKI) Title : Stepping into the RING; Preclinical models in the fight against hereditary breast

cancer University : University of Amsterdam (co)Promotors : Berns A. Date : 14-9-2012 Name : Dubbelman, A-C. (NKI) Title : Bioanalysis and metabolite identification of anticancer drugs in mass balance

studies University : University Utrecht (co)Promotors : Schellens, J. Date : 23-5-2012 Name : Frijns, E. (NKI) Title : Controling hemidesmosome dynamics by phosphorylation of the integrin Beta 4

subunit University : University of Amsterdam (co)Promotors : Berns, A. Date : 10-5-2012 Name: : de Graaf P. (VUmc) Title: : Diagnostic Imaging in retinoblastoma University: : Vrije Universiteit Amsterdam (co)Promotors: : Castelijns J.A., van der Valk P., Moll A.C., Imhof S. Date: : 4/5/2012 Name : de Greef M. (AMC) Title : Loco-regional hyperthermia treatment planning. Optimisation under uncertainty University : University of Amsterdam (co)Promotors : Koning C.C.E., Crezee J. Date : 09/02/2012 Name: : Gül N. (VUmc) Title: : Surgery-induced liver metastasis: how it begins and how to end it University: : Vrije Universiteit Amsterdam (co)Promotors: : Beelen R.H.J., van Egmond M. Date: : 9/27/2012 Name : Houben, A. (NKI) Title : Autotaxin, biochemical and functional studies University : University Leiden (co)Promotors : Moolenaar, W. Date : 25-9-2011 Name : Jak M. (AMC) Title : Microenvironment and anti-CD20 based therapies in CLL University : University of Amsterdam (co)Promotors : van Oers M.H.J., van Lier R.A.W., Eldering E. Date : 24/04/2012


Name : de Jong K. (AMC) Title : Diagnostic approach to pancreatic cystic lesions University : University of Amsterdam (co)Promotors : Fockens P., Bruno M.J., Dijkgraaf M.G.W. Date : 06/09/2012 Name : Ketema, M. (NKI) Title : Nesprin-3 as a LINC between the nucleus and intermediate filaments University : University van Amsterdam (co)Promotors : Berns, A. Date : 02-10-2012 Name : Kodach V.M. (AMC) Title : Development of functional near-infrared optical coherence tomography University : University of Amsterdam (co)Promotors : van Leeuwen A.G.J.M., Kalkman J., Faber D.J. Date : 14/03/2012 Name : Van Kouwenhove, M. (NKI) Title : Don't shoot the messenger - Non-coding RNA's and RNA binding proteins in control

of gene expression University : University of Rotterdam (co)Promotors : Agami R. Date : 26-10-2012 Name : Kuiken, H. (NKI) Title : Hitting cancer where it hurts most University : University Utrecht (co)Promotors : Bernards R. Date : 13-9-2012 Name : Kurdo B. (AMC) Title : Renal tumor ablation: beyond limitations of biopsy and follow-up University : University of Amsterdam (co)Promotors : de la Rosette J.J.M.C.H., Laguna Pes M.P., Wijkstra H. Date : 18/12/2012 Name : Lamers S.G.M. (AMC) Title : New therapeutic targets in the intrinsic apoptotic pathway in neuroblastoma University : University of Amsterdam (co)Promotors : Versteeg R., Caron H.N., Molenaar J.J. Date : 15/06/2012 Name: : de Langen A.J. (VUmc) Title: : Response evaluation during targeted therapy: early incorporation of imaging

biomarkers. University: : Vrije Universiteit Amsterdam (co)Promotors: : Smit E.F., Hoekstra O.S., Lubberdink M. Date: : 4/27/2012 Name : De Leeuw, R. (NKI) Title : Molecular understanding of tamoxifen resistance in breast cancer University : University Leiden (co)Promotors : Neefjes, J. Date : 9-2-2012 Name: : Louwers J.A. (VUmc) Title: : The role of digitaal colposcopy, the human papillomavirus and biomarkers University: : Vrije Universiteit Amsterdam (co)Promotors: : Verheijen R.H.M., Meijer C.J.L.M., Snijders P.J.F. Date: : 4/12/2012


Name: : van Luijn M.M. (VUmc) Title: : Impaired antigen expression as immune escape mechanism in Acute Myeloid

Leukemia University: : Vrije Universiteit Amsterdam (co)Promotors: : Ossenkoppele G.J., van de Loosdrecht A.A. Date: : 2/15/2012 Name: : Lind J.S.W. (VUmc) Title: : Management of advanced non-small cell lung cancer: moving towards a more

personalized approach. University: : Vrije Universiteit Amsterdam (co)Promotors: : Smit E.F., Senan S. Date: : 3/26/2012 Name: : van Litsenburg R.R.L. (VUmc) Title: : Paediatric acute lymphoblastic leukemia. Quality of life and cost effectiveness of

treatment. University: : Vrije Universiteit Amsterdam (co)Promotors: : Gemke R.J.B.J., Kaspers G.J.L., Huisman J. Date: : 5/8/2012 Name : Nijkamp. J. (NKI) Title : (Un)-Certainties in Radiotherapy of Rectal Cancer University : University of Amsterdam (co)Promotors : Van Herk, M. Date : 11-4-2012 Name : Nijwening J. (NKI) Title : Screening for novel drug targets in cancer (co)Promotors : R.Bernards University : University Utrecht Date : 10-1-2012 Name : Oosterhuis, K. (NKI) Title : Preclinical development of DNA vaccine candidates for the treatment of HPV16

induces malignancies University : University Leiden (co)Promotors : Hannen, J. Date : 27-6-2012 Name : Paul, P. (NKI) Title : The Systems Biology of MHC Class II Antigen Presentation University : University Leiden (co)Promotors : Neefjes, J.J. Date : 6-9-2012 Name : van Rooijen D. (AMC) Title : Improving radiation dose delivery for moving targets using image guidance University : University of Amsterdam (co)Promotors : Koning C.C.E., Bel A., Hulshof M.C.C.M. Date : 23/05/2012 Name : Tromp J.M.(AMC) Title : The microenvironment and treatment resistance in chronic lymphocytic leukemia University : University of Amsterdam (co)Promotors : van Oers M.H.J., Eldering E.F. Date : 05/10/2012 Name: : van der Veldt A.A.M. (VUmc) Title: : Towards personalized treatment planning of chemotherapy:[11C] docetaxel

studies in lung cancer patients. Sunitinib for advanced renal cell cancer: pharmacodynamic aspects. University: : Vrije Universiteit Amsterdam (co)Promotors: : Lammertsma A.A., Smit E.F., Lubberdink M. Boven E., Haanen J.B.A.G., van den Eertwegh A.J.M. Date: : 7/4/2012


Name : Vissers J. (NKI) Title : Regulation of histone H2A ubiquitination in the maintenance of genome stability University : University of Amsterdam (co)Promotors : Lohuizen, M.van Date : 9-11-2012 Name: : Vosjan M.J.W.D. (VUmc) Title: : Nanobodies, a novel class of antibodies to improve imaging and blockage of

growth factors and their receptors in cancer. University: : Vrije Universiteit Amsterdam (co)Promotors: : van Dongen G.A.M.S., Visser G.W.M. Date: : 11/29/2012 Name: : Weijers M. (VUmc) Title: : Oral squamous cell carcinoma; some epidemiological and clinicopathological

aspects University: : Vrije Universiteit Amsterdam (co)Promotors: : van der Waal I. Date: : 10/29/2012


scientific publications

annex

Scientific publications - 75

Annex 4. Scientific publications 1. Aarntzen EHJG, Bol K, Schreibelt G, Jacobs JFM, Lesterhuis WJ, van Rossum MM, Adema GJ, Figdor CG, Punt CJA, de

Vries IJM. Skin-Test Infiltrating Lymphocytes Early Predict Clinical Outcome of Dendritic Cell-Based Vaccination in Metastatic Melanoma. Cancer Research 2012; 72(23): 6102-6110. (AMC)

2. Aarntzen EHJG, de Vries IJM, Göertz JH, Beldhuis-Valkis M, Brouwers HMLM, van de Rakt MWMM, van der Molen RG, Punt CJA, Adema GJ, Tacken PJ, Joosten I, Jacobs JFM. Humoral anti-KLH responses in cancer patients treated with dendritic cell-based immunotherapy are dictated by different vaccination parameters. Cancer Immunology Immunotherapy 2012; 61(11): 2003-2011. (AMC)

3. Aarntzen EHJG, Schreibelt G, Bol K, Lesterhuis WJ, Croockewit AJ, de Wilt JHW, van Rossum MM, Blokx WAM, Jacobs JFM, Duiveman-de Boer T, Schuurhuis DH, Mus R, Thielemans K, de Vries IJM, Figdor CG, Punt CJA, Adema GJ. Vaccination with mRNA-Electroporated Dendritic Cells Induces Robust Tumor Antigen-Specific CD4(+) and CD8(+) T Cells Responses in Stage III and IV Melanoma Patients. Clinical Cancer Research 2012; 18(19): 5460-5470. (AMC)

4. Aarntzen EHJG, Srinivas M, Punt CJA, Figdor CG, Oyen WJG, de Vries IJM. Insight into the dynamics, localization and magnitude of antigen-specific immune responses by [(18)F]FLT PET imaging. Oncoimmunology 2012; 1(5): 744-745. (AMC)

5. Abdallah AM, Rashid M, Adroub SA, Arnoux M, Ali S, van Soolingen D, Bitter W, Pain A. Complete Genome Sequence of Mycobacterium phlei Type Strain RIVM601174. Journal of Bacteriology 2012; 194: 3284-3285. (VUmc)

6. Ackerstaff AH, Rasch CRN, Balm AJM, de Boer JP, Wiggenraad R, Rietveld DHF, Gregor RT, Kröger R, Hauptmann M, Vincent A, Hilgers FJM. Five-year quality of life results of the randomized clinical phase III (RADPLAT) trial, comparing concomitant intra-arterial versus intravenous chemoradiotherapy in locally advanced head and neck cancer. Head And Neck-Journal For The Sciences And Specialties Of The Head And Neck 2012; 34(7): 974-980. (AMC/NKI)

7. Adams H, Raijmakers P, Smulders Y. Polymyalgia Rheumatica and Interspinous FDG Uptake on PET/CT. Clinical Nuclear Medicine 2012; 37: 502-505. (VUmc)

8. Adar Y, Stark M, Bram EE, Nowak-Sliwinska P, van den Bergh H, Szewczyk G, Sarna T, Skladanowski A, Griffioen AW, Assaraf YG. Imidazoacridinone-dependent lysosomal photodestruction: a pharmacological Trojan horse approach to eradicate multidrug-resistant cancers. Cell Death & Disease 2012; 3: . (VUmc)

9. Adema AD, Smid K, Losekoot N, Honeywell RJ, Verheul HM, Myhren F, Sandvold ML, Peters GJ. Metabolism and accumulation of the lipophilic deoxynucleoside analogs elacytarabine and CP-4126. Investigational New Drugs 2012; 30: 1908-1916. (VUmc)

10. Adham M, Kurniawan AN, Muhtadi AI, Roezin A, Hermani B, Gondhowiardjo S, Tan IB, Middeldorp JM. Nasopharyngeal carcinoma in Indonesia: epidemiology, incidence, signs, and symptoms at presentation. Chin J Cancer 2012; 31: 185-96 (NKI/VUmc)

11. Aguilar G, Choi B, Broekgaarden M, Yang O, Yang B, Ghasri P, Chen JK, Bezemer R, Nelson JS, van Drooge AM, Wolkerstorfer A, Kelly KM, Heger M. An Overview of Three Promising Mechanical, Optical, and Biochemical Engineering Approaches to Improve Selective Photothermolysis of Refractory Port Wine Stains. Annals Of Biomedical Engineering 2012; 40(2): 486-506. (AMC)

12. Ahmed Ali U, Nieuwenhuijs VB, van Eijck CH, Gooszen HG, van Dam RM, Busch OR, Dijkgraaf MGW, Mauritz FA, Jens S, Mast J, van Goor H, Boermeester MA. Clinical outcome in relation to timing of surgery in chronic pancreatitis: a nomogram to predict pain relief. Archives Of Surgery 2012; 147(10): 925-932. (AMC)

13. Akca BI, Nguyen VD, Kalkman J, Ismail N, Sengo G, Sun F, Driessen A, van Leeuwen TG, Pollnau M, Worhoff K, de Ridder RM. Toward Spectral-Domain Optical Coherence Tomography on a Chip. Ieee Journal Of Selected Topics In Quantum Electronics 2012; 18(3): 1223-1233. (AMC)

14. Al Hussainy R, Verbeek J, van der Born D, Molthoff C, Booij J, Herscheid JDM. Synthesis, biodistribution and PET studies in rats of F-18-Labeled bridgehead fluoromethyl analogues of WAY-100635. Nuclear Medicine and Biology 2012; 39: 1068-1076. (VUmc)

15. Albers HM, Ovaa H. Chemical evolution of autotaxin inhibitors. Chem Rev 2012; 112: 2593-260 (NKI) 16. Alberts VP, Minnee RC, Bemelman FJ, van Donselaar-van der Pant KAMI, Laguna Pes P, Idu MM. Ureteral

reconstruction after renal transplantation: clinical outcome and risk factors. Urologia Internationalis 2012; 88(3): 333-337. (AMC)

17. Alderliesten T, Sonke J, Betgen A, van Vliet-Vroegindeweij C, Remeijer P. 3D surface imaging for monitoring intrafraction motion in frameless stereotactic body radiotherapy of lung cancer. Radiotherapy And Oncology 2012; 105(2): 155-160. (AMC/NKI)

18. Alexiusdottir KK, Moller PH, Snaebjornsson P, Jonasson L, Olafsdottir EJ, Bjornsson ES, Tryggvadottir L, Jonasson JG. Association of symptoms of colon cancer patients with tumor location and TNM tumor stage. Scandinavian Journal of Gastroenterology 2012; 47: 795-801. (VUmc)

19. Al-Janabi S, Huisman A, Vink A, Leguit RJ, Offerhaus GJA, ten Kate FJW, van Diest PJ. Whole slide images for primary diagnostics of gastrointestinal tract pathology: a feasibility study. Human Pathology 2012; 43(5): 702-707. (AMC)

20. Al-Janabi S, Huisman A, Vink A, Leguit RJ, Offerhaus GJA, ten Kate FJW, van Dijk MR, van Diest PJ. Whole slide images for primary diagnostics in dermatopathology: a feasibility study. Journal Of Clinical Pathology 2012; 65(2): 152-158. (AMC)

76 - Scientific publications

21. Althof V, van Haaren P, Westendorp R, Nuver T, Kramer D, Ikink M, Bel A, Minken A. A quality assurance tool for helical tomotherapy using a step-wedge phantom and the on-board MVCT detector. Journal Of Applied Clinical Medical Physics 2012; 13(1): 148-163. (AMC)

22. Alvarez Paez AM, Brouwer OR, Veenstra HJ, van der Hage JA, Wouters M, Nieweg OE, Valdés-Olmos RA. Decisive role of SPECT/CT in localization of unusual periscapular sentinel nodes in patients with posterior trunk melanoma: three illustrative cases and a review of the literature. Melanoma Res 2012; 22: 278- 283 (NKI)

23. Aman J, Thunnissen E, Paul MA, Amerongen GPV, Vonk-Noordegraaf A. Successful Treatment of Diffuse Pulmonary Lymphangiomatosis With Bevacizumab. Annals of Internal Medicine 2012; 156: 839-840. (VUmc)

24. Ameziane N, Sie DLS, Dentro S, Ariyurek Y, Kerkhoven L, Joenje H, Dorsman JC, Ylstra B, Gille JJP, Sistermans EA, de Winter JP. Diagnosis of fanconi anemia: mutation analysis by next-generation sequencing. Anemia 2012; 2012: 132856. (VUmc)

25. Amore A, Wals K, Koekoek E, Hoppes R, Toebes M, Schumacher TN, Rodenko B, Ovaa H. Development of a Hypersensitive Periodate-Cleavable Amino Acid that is Methionine- and Disulfide-Compatible and its Application in MHC Exchange Reagents for T Cell Characterisation. Chembiochem 2013: 14: 123-131 (NKI)

26. Anastasiadis A, Cordeiro E, Bus MT, Alivizatos G, de la Rosette JJMCH, de Reijke TM. Follow-up procedures for non-muscle-invasive bladder cancer: an update. Expert Review Of Anticancer Therapy 2012; 12(9): 1229-1241. (AMC)

27. Anastasiadis A, de Reijke TM. Best practice in the treatment of nonmuscle invasive bladder cancer. Therapeutic Advances In Urology 2012; 4(1): 13-32. (AMC)

28. Andersen RS, Kvistborg P, Frosig TM, Pedersen NW, Lyngaa R, Bakker AH, Shu CJ, Straten P, Schumacher TN, Hadrup SR. Parallel detection of antigen-specific T cell responses by combinatorial encoding of MHC multimers. Nat Prot 2012; 7: 891-902 (NKI)

29. Andersen RS, Thrue CA, Junker N, Lyngaa R, Donia M, Ellebaek E, Svane IM, Schumacher TN, Thor Straten P, Hadrup SR. Dissection of T-cell antigen specificity in human melanoma. Cancer Res 2012; 72: 1642-50 (NKI)

30. Anderson AL, Zheng Y, Song DC, LaRosa D, Van Rooijen N, Kierstein G, Kierstein S, Haczku A, Levinson AI. The B-cell superantigen Finegoldia magna protein L causes pulmonary inflammation by a mechanism dependent on MyD88 but not B cells or immunoglobulins. Inflammation Research 2012; 61: 161-169. (VUmc)

31. André P, Saubaméa B, Cochois- Guégan V, Marie-Claire C, Cattelotte J, Smirnova M, Schinkel AH, Scherrmann JM, Cisternino S. Transport of biogenic amine neurotransmitters at the mouse blood-retina and blood-brain barriers by uptake1 and uptake2. J Cereb Blood Flow Metab 2012; 32: 1989-2001 (NKI)

32. Annema JT. Mediastinal abscess formation after EUS-guided FNA in patients with sarcoidosis : Response. Gastrointestinal Endoscopy 2012; 76(5): 1079-. (AMC)

33. Antoniou AC, Kuchenbaecker KB, Soucy P, Beesley J, Chen X, McGuffog L, Lee A, Barrowdale D, Healey S, Sinilnikova OM, Caligo MA, Loman N, Harbst K, Lindblom A, Arver B, Rosenquist R, Karlsson P, Nathanson K, Domchek S, Rebbeck T, Jakubowska A, Lubinski J, Jaworska K, Durda K, Złowowcka-Perłowska E, Osorio A, Durán M, Andrés R, Benítez J, Hamann U, Hogervorst FB, van Os TA, Verhoef S , Meijers-Heijboer HEJ, Wijnen J, Gómez Garcia EB, Ligtenberg MJ, Kriege M, Collée JM, Ausems MG, Oosterwijk JC, Peock S, Frost D, Ellis SD, Platte R, Fineberg E, Evans DG, Lalloo F, Jacobs C, Eeles R, Adlard J, Davidson R, Cole T, Cook J, Paterson J, Douglas F, Brewer C, Hodgson S, Morrison PJ, Walker L, Rogers MT, Donaldson A, Dorkins H, Godwin AK, Bove B, Stoppa-Lyonnet D, Houdayer C, Buecher B, de Pauw A, Mazoyer S, Calender A, Léoné M, Bressac-de Paillerets B, Caron O, Sobol H, Frenay M, Prieur F, Ferrer SU, Mortemousque I, Buys S, Daly M, Miron A, Terry MU, Hopper JL, John EM, Southey M, Goldgar D, Singer CF, Fink-Retter A, Muy-Kheng T, Kaulich DU, Hansen TV, Nielsen FC, Barkardottir RB, Gaudet M, Kirchhoff T, Joseph V, Dutra-Clarke A, Offit K, Piedmonte M, Kirk J, Cohn D, Hurteau J, Byron J, Fiorica J, Toland AE, Montagna M, Oliani C, Imyanitov E, Isaacs C, Tihomirova L, Blanco I, Lazaro C, Teulé A, Del Valle J, Gayther SA, Odunsi K, Gross J, Karlan BY, Olah E, Teo SH, Ganz PA, Beattie MS, Dorfling CM, van Rensburg EU, Diez O, Kwong A, Schmutzler RK, Wappenschmidt B, Engel C, Meindl A, Ditsch N, Arnold N, Heidemann S, Niederacher D, Preisler-Adams S, Gadzicki D, Varon-Mateeva R, Deissler H, Gehrig A, Sutter C, Kast K, Fiebig B, Schäfer D, Caldes T, de la Hoya M, Nevanlinna H, Muranen TA, Lespérance B, Spurdle AB, Neuhausen SL, Ding YC, Wang X, Fredericksen Z, Pankratz VS, Lindor NM, Peterlongo P, Manoukian S, Peissel B, Zaffaroni D, Bonanni B, Bernard L, Dolcetti R, Papi L, Ottini L, Radice P, Greene MH, Loud JT, Andrulis IL, Ozcelik H, Mulligan AU, Glendon G, Thomassen M, Gerdes A, Jensen UB, Skytte A, Kruse TA, Chenevix-Trench G, Couch FJ, Simard J, Easton DF. Common variants at 12p11, 12q24, 9p21, 9q31.2 and in ZNF365 are associated with breast cancer risk for BRCA1 and/or BRCA2 mutation carriers. Breast Cancer Research 2012; 14(1): R33-. (AMC/NKI/VUmc)

34. Arbyn M, Ronco G, Anttila A, Meijer CJLM, Poljak M, Ogilvie G, Koliopoulos G, Naucler P, Sankaranarayanan R, Peto J. Evidence regarding human papillomavirus testing in secondary prevention of cervical cancer. Vaccine 2012; 30: F88-F99. (VUmc)

35. Ardizzoni A, Tiseo M, Boni L, Vincent AD, Passalacqua R, Buti S, Amoroso D, Camerini A, Labianca R, Genestreti G, Boni C, Ciuffreda L, Di Costanzo F, de Marinis F, Crino L, Santo A, Pazzola A, Barbieri F, Zilembo N, Colantonio I, Tibaldi C, Mattioli R, Cafferata MA, Camisa R, Smit EF. Pemetrexed Versus Pemetrexed and Carboplatin As Second-Line Chemotherapy in Advanced Non-Small-Cell Lung Cancer: Results of the GOIRC 02-2006 Randomized Phase II Study and Pooled Analysis With the NVALT7 Trial. J Clin Oncol 2012; 30: 4501-7 (NKI/VUmc)

36. Arends S, Grootscholten C, Derksen RHWM, Berger SP, de Sevaux RGL, Voskuyl AE, Bijl M, Berden JHM. Long-term follow-up of a randomised controlled trial of azathioprine/methylprednisolone versus cyclophosphamide in patients with proliferative lupus nephritis. Annals of the Rheumatic Diseases 2012; 71: 966-973. (VUmc)

37. Ariotti S, Beltman JB, Chodaczek G, Hoekstra ME, van Beek AE, Gomez- Eerland R, Ritsma L, van Rheenen J, Maree AF, Zal T, de Boer RJ, Haanen, JB, Schumacher TN. Tissue-resident memory CD8+ T cells continuously patrol skin epithelia to quickly recognize local antigen. Proc Natl Acad Sci USA 2012; 109: 19739-44 (NKI)

38. Ariotti S, Haanen JB, Schumacher TN. Behavior and function of tissueresident memory T cells. Adv Immunol 2012; 114: 203-16 (NKI)

39. Arnes JB, Stefansson IM, Straume O, Baak JPA, Lonning PE, Foulkes WD, Akslen LA. Vascular proliferation is a prognostic factor in breast cancer. Breast Cancer Research and Treatment 2012; 133: 501-510. (VUmc)

40. Aruhuri B, Tarivonda L, Tenet V, Sinha R, Snijders PJF, Clifford G, Pang J, McAdam M, Meijer CJLM, Frazer IH, Franceschi S. Prevalence of Cervical Human Papillomavirus (HPV) Infection in Vanuatu. Cancer Prevention Research 2012; 5: 746-753. (VUmc)

41. Asselin MC, O'Connor JPB, Boellaard R, Thacker NA, Jackson A. Quantifying heterogeneity in human tumours using MRI and PET. European Journal of Cancer 2012; 48: 447-455. (VUmc)


42. Atak ZK, De Keersmaecker K, Gianfelici V, Geerdens E, Vandepoel R, Pauwels D, Porcu M, Lahortiga I, Brys V, Dirks WG, Quentmeier H, Cloos J, Cuppens H, Uyttebroeck A, Vandenberghe P, Cools J, Aerts S. High Accuracy Mutation Detection in Leukemia on a Selected Panel of Cancer Genes. PloS one 2012; 7: . (VUmc)

43. Atema JJ, Amri R, Busch ORC, Rauws EAJ, Gouma DJ, Nieveen van Dijkum EJM. Surgical treatment of gastrinomas: a single-centre experience. HPB 2012; 14(12): 833-838. (AMC)

44. Avan A, Crea F, Paolicchi E, Funel N, Galvani E, Marquez VE, Honeywell RJ, Danesi R, Peters GJ, Giovannetti E. Molecular Mechanisms Involved in the Synergistic Interaction of the EZH2 Inhibitor 3-Deazaneplanocin A with Gemcitabine in Pancreatic Cancer Cells. Molecular Cancer Therapeutics 2012; 11: 1735-1746. (VUmc)

45. Azijli K, Yuvaraj S, Peppelenbosch MP, Wurdinger T, Dekker H, Joore J, van Dijk E, Quax WJ, Peters GJ, de Jong S, Kruyt FAE. Kinome profiling of non-canonical TRAIL signaling reveals RIP1-Src-STAT3-dependent invasion in resistant non-small cell lung cancer cells. Journal of Cell Science 2012; 125: 4651-4661. (VUmc)

46. Baan B, Dihal AA, Hoff E, Bos CL, Voorneveld PW, Koelink PJ, Wildenberg ME, Muncan V, Heijmans J, Verspaget HW, Richel DJ, Hardwick JCH, Hommes DW, Peppelenbosch MP, van den Brink GR. 5-Aminosalicylic acid inhibits cell cycle progression in a phospholipase D dependent manner in colorectal cancer. GUT 2012; 61(12): 1708-1715. (AMC/Vumc)

47. Baas P. Primum non nocere? Does this also apply to mesothelioma? Lung Cancer 2012; 77: 1 (NKI) 48. Bachas C, Schuurhuis GJ, Assaraf YG, Kwidama ZJ, Kelder A, Wouters F, Snel AN, Kaspers GJL, Cloos J. The role of

minor subpopulations within the leukemic blast compartment of AML patients at initial diagnosis in the development of relapse. Leukemia 2012; 26: 1313-1320. (VUmc)

49. Backes DM, Bleeker MCG, Meijer CJLM, Hudgens MG, Agot K, Bailey RC, Ndinya-Achola JO, Hayombe J, Hogewoning CJA, Moses S, Snijders PJF, Smith JS. Male circumcision is associated with a lower prevalence of human papillomavirus-associated penile lesions among Kenyan men. International Journal of Cancer 2012; 130: 1888-1897. (VUmc)

50. Baglio SR, Pegtel DM, Baldini N. Mesenchymal stem cell secreted vesicles provide novel opportunities in (stem) cell-free therapy. Frontiers in Physiology 2012; 3: 359. (VUmc)

51. Bakhshi-Raiez F, de Keizer NF, Cornet R, Dorrepaal M, Dongelmans D, Jaspers MWM. A usability evaluation of a SNOMED CT based compositional interface terminology for intensive care. International Journal Of Medical Informatics 2012; 81(5): 351-362. (AMC)

52. Bakker JL, de Winter JP. A Role for ATM in Hereditary Pancreatic Cancer. Cancer Discovery 2012; 2: 14-15. (VUmc) 53. Bakker OJ, van Santvoort HC, van Brunschot S, Geskus RB, Besselink MG, Bollen TL, van Eijck CH, Fockens P,

Hazebroek EJ, Nijmeijer RM, Poley J, van Ramshorst B, Vleggaar FP, Boermeester MA, Gooszen HG, Weusten BL, Timmer R. Endoscopic Transgastric vs Surgical Necrosectomy for Infected Necrotizing Pancreatitis A Randomized Trial. Jama-Journal Of The American Medical Association 2012; 307(10): 1053-1061. (AMC)

54. Bakker ST, Van de Vrugt HJ, Visser JA, Delzenne-Goette A, Van der Wal A, Berns MAD, Van de Ven M, Oostra AB, De Vries S, Kramer P, Arwert F, Van der Valk M, De Winter JP, and Te Riele H. Fancf-deficient mice are prone to develop ovarian tumors. J Pathol 2012; 226: 28-39 (NKI/Vumc)

55. Balink H, Verberne HJ, Bennink RJ, van Eck-Smit BLF. A Rationale for the Use of F18-FDG PET/CT in Fever and Inflammation of Unknown Origin. International Journal Of Molecular Imaging 2012; (2012): 165080-. (AMC)

56. Balzarini J, Gago F, Kulik W, van Kuilenburg ABP, Karlsson A, Peterson MA, Robins MJ. Introduction of a fluorine atom at C3 of 3-deazauridine shifts its antimetabolic activity from inhibition of CTP synthetase to inhibition of orotidylate decarboxylase, an early event in the de novo pyrimidine nucleotide biosynthesis pathway. Journal Of Biological Chemistry 2012; 287(36): 30444-30454. (AMC)

57. Balzarolo M, Karrich JJ, Engels S, Blom B, Medema JP, Wolkers MC. The transcriptional regulator NAB2 reveals a two-step induction of TRAIL in activated plasmacytoid DCs. European Journal Of Immunology 2012; 42(11): 3019-3027. (AMC)

58. Barendse RM, Doornebosch PG, Bemelman WA, Fockens P, Dekker E, de Graaf EJR. Transanal employment of single access ports is feasible for rectal surgery. Annals Of Surgery 2012; 256(6): 1030-1033. (AMC)

59. Barendse RM, van den Broek FJC, van Schooten J, Bemelman WA, Fockens P, de Graaf EJR, Dekker E. Endoscopic mucosal resection vs transanal endoscopic microsurgery for the treatment of large rectal adenomas. Colorectal Disease 2012; 14(4): e191-e196. (AMC)

60. Barendse RM, Verlaan T, Bemelman WA, Fockens P, Dekker E, Nonner J, de Graaf EJR. Transanal single port surgery: selecting a suitable access port in a porcine model. Surgical Innovation 2012; 19(3): 323-326. (AMC)

61. Barker N, Rookmaaker MB, Kujala P, Ng A, Leushacke M, Snippert H, van de Wetering M, Tan S, Van Es JH, Huch M, Poulsom R, Verhaar MC, Peters PJ, Clevers H. Lgr5(+ve) stem/progenitor cells contribute to nephron formation during kidney development. Cell Rep 2012; 2: 540-52 (NKI)

62. Baron F, Labopin M, Niederwieser D, Vigouroux S, Cornelissen JJ, Malm C, Vindelov LL, Blaise D, Janssen JJWM, Petersen E, Socie G, Nagler A, Rocha V, Mohty M. Impact of graft-versus-host disease after reduced-intensity conditioning allogeneic stem cell transplantation for acute myeloid leukemia: a report from the Acute Leukemia Working Party of the European group for blood and marrow transplantation. Leukemia 2012; 26: 2462-2468. (VUmc)

63. Baron F, Suciu S, Amadori S, Muus P, Zwierzina H, Denzlinger C, Delforge M, Thyss A, Selleslag D, Indrak K, Ossenkoppele G, de Witte T. Value of infliximab (Remicade (R)) in patients with low-risk myelodysplastic syndrome: final results of a randomized phase II trial (EORTC trial 06023) of the EORTC Leukemia Group. Haematologica-The Hematology Journal 2012; 97: 529-533. (VUmc)

64. Barral P, Sanchez-Nino MD, Van Rooijen N, Cerundolo V, Batista FD. The location of splenic NKT cells favours their rapid activation by blood-borne antigen. EMBO Journal 2012; 31: 2378-2390. (VUmc)

65. Bartelink H, Bourgier C, Elkhuizen P. Has partial breast irradiation by IORT or brachytherapy been prematurely introduced into the clinic? Radiother Oncol 2012; 104: 139-42 (NKI)

66. Bartels SAL, van der Zaag ES, Dekker E, Buskens CJ, Bemelman WA. The effect of colonoscopic tattooing on lymph node retrieval and sentinel lymph node mapping. Gastrointestinal Endoscopy 2012; 76(4): 793-800. (AMC)

67. Barwari K, de Bruin DM, Faber DJ, van Leeuwen TG, de la Rosette JJ, Laguna MP. Differentiation between normal renal tissue and renal tumours using functional optical coherence tomography: a phase I in vivo human study. BJU International 2012; 110(8 Part B): E415-E420. (AMC)

68. Barwari K, de la Rosette JJ, Laguna MP. The penetration of renal mass biopsy in daily practice: a survey among urologists. Journal Of Endourology 2012; 26(6): 737-747. (AMC)


69. Bastiaannet E, Hoekstra OS, de Jong JR, Brouwers AH, Suurmeijer AJH, Hoekstra HJ. Prognostic value of the standardized uptake value for F-18-fluorodeoxyglucose in patients with stage IIIB melanoma. European Journal of Nuclear Medicine and Molecular Imaging 2012; 39: 1592-1598. (VUmc)

70. Bastiaannet E, Uyl-de Groot CA, Brouwers AH, van der Jagt EJ, Hoekstra OS, Oyen W, Verzijlbergen F, van Ooijen B, Thompson JF, Hoekstra HJ. Cost-effectiveness of Adding FDG-PET or CT to the Diagnostic Work-up of Patients With Stage III Melanoma. Annals of Surgery 2012; 255: 771-776. (VUmc)

71. Beekman CA, Buckle T, van Leeuwen AC, et al. Questioning the value of (99m)Tc-HYNIC-annexin V based response monitoring after docetaxel treatment in a mouse model for hereditary breast cancer. Appl Radiat Isot 2011; 69: 656-662 (NKI)

72. Beekman R, Valkhof MG, Sanders MA, van Strien PMH, Haanstra JR, Broeders L, Geertsma-Kleinekoort WM, Veerman AJP, Valk PJM, Verhaak RG, Lowenberg B, Touw IP. Sequential gain of mutations in severe congenital neutropenia progressing to acute myeloid leukemia. Blood 2012; 119: 5071-5077. (VUmc)

73. Beelen K, Zwart W, Linn SC. Can predictive biomarkers in breast cancer guide adjuvant endocrine therapy? Nat Rev Clin Oncol 2012; 9: 529-541 (NKI)

74. Beerepoot MAJ, ter Riet G, Nys S, van der Wal WM, de Borgie CAJM, de Reijke TM, Prins JM, Koeijers J, Verbon A, Stobberingh E, Geerlings SE. Lactobacilli vs antibiotics to prevent urinary tract infections: a randomized, double-blind, noninferiority trial in postmenopausal women. Archives Of Internal Medicine 2012; 172(9): 704-712. (AMC)

75. Beetz I, Schilstra C, Burlage FR, Koken PW, Doornaert P, Bijl HP, Chouvalova O, Leemans CR, de Bock GH, Christianen MEMC, van der Laan BFAM, Vissink A, Steenbakkers RJHM, Langendijk JA. Development of NTCP models for head and neck cancer patients treated with three-dimensional conformal radiotherapy for xerostomia and sticky saliva: The role of dosimetric and clinical factors. Radiotherapy and Oncology 2012; 105: 86-93. (VUmc)

76. Beetz I, Schilstra C, van der Schaaf A, van den Heuvel ER, Doornaert P, van Luijk P, Vissink A, van der Laan BFAM, Leemans CR, Bijl HP, Christianen MEMC, Steenbakkers RJHM, Langendijk JA. NTCP models for patient-rated xerostomia and sticky saliva after treatment with intensity modulated radiotherapy for head and neck cancer: The role of dosimetric and clinical factors. Radiotherapy and Oncology 2012; 105: 101-106. (VUmc)

77. Beetz I, Schilstra C, van Luijk P, Christianen MEMC, Doornaert P, Bijl HP, Chouvalova O, van den Heuvel ER, Steenbakkers RJHM, Langendijk JA. External validation of three dimensional conformal radiotherapy based NTCP models for patient-rated xerostomia and sticky saliva among patients treated with intensity modulated radiotherapy. Radiotherapy and Oncology 2012; 105: 94-100. (VUmc)

78. Beimers L, Louwerens JWK, Tuijthof GJM, Jonges R, van Dijk CNN, Blankevoort L. CT measurement of range of motion of ankle and subtalar joints following two lateral column lengthening procedures. Foot And Ankle International 2012; 33(5): 386-393. (AMC)

79. Belt EJT, Brosens RPM, Delis-van Diemen PM, Bril H, Tijssen M, van Essen DF, Heymans MW, Belien JAM, Stockmann HBAC, Meijer S, Meijer GA. Cell Cycle Proteins Predict Recurrence in Stage II and III Colon Cancer. Annals of Surgical Oncology 2012; : 682-692. (VUmc)

80. Belt EJT, Stockmann HBAC, Abis GSA, de Boer JM, de Lange-de Klerk ESM, van Egmond M, Meijer GA, Oosterling SJ. Peri-Operative Bowel Perforation in Early Stage Colon Cancer is Associated with an Adverse Oncological Outcome. Journal of Gastrointestinal Surgery 2012; 16: 2260-2266. (VUmc)

81. Belt EJT, Velde EAT, Krijgsman O, Brosens RPM, Tijssen M, van Essen HF, Stockmann HBAC, Bril H, Carvalho B, Ylstra B, Bonjer HJ, Meijer GA. High Lymph Node Yield is Related to Microsatellite Instability in Colon Cancer. Annals of Surgical Oncology 2012; 19: 1222-1230. (VUmc)

82. Benard EL, van der Sar AM, Ellett F, Lieschke GJ, Spaink HP, Meijer AH. Infection of zebrafish embryos with intracellular bacterial pathogens. Journal of Visualized Experiments 2012; 15: 61. (VUmc)

83. Bennebroek Evertsz' F, Thijssens NAM, Stokkers PCF, Grootenhuis MA, Bockting CLH, Nieuwkerk PT, Sprangers MAG. Do Inflammatory Bowel Disease patients with anxiety and depressive symptoms receive the care they need? Journal Of Crohns & Colitis 2012; 6(1): 68-76. (AMC)

84. Bennett C, Vakil N, Bergman J, Harrison R, Odze R, Vieth M, Sanders S, Gay L, Pech O, Longcroft-Wheaton G, Romero Y, Inadomi J, Tack J, Corley DA, Manner H, Green S, Al Dulaimi D, Ali H, Allum B, Anderson M, Curtis H, Falk G, Fennerty MB, Fullarton G, Krishnadath K, Meltzer SJ, Armstrong D, Ganz R, Cengia G, Going JJ, Goldblum J, Gordon C, Grabsch H, Haigh C, Hongo M, Johnston D, Forbes-Young R, Kay E, Kaye P, Lerut T, Lovat LB, Lundell L, Mairs P, Shimoda T, Spechler S, Sontag S, Malfertheiner P, Murray I, Nanji M, Poller D, Ragunath K, Regula J, Cestari R, Shepherd N, Singh R, Stein HJ, Talley NJ, Galmiche J, Tham TCK, Watson P, Yerian L, Rugge M, Rice T W, Hart J, Gittens S, Hewin D, Hochberger J, Kahrilas P, Preston S, Sampliner R, Sharma P, Stuart R, Wang K, Waxman I, Abley C, Loft D, Penman I, Shaheen NJ, Chak A, Davies G, Dunn L, Falck-Ytter Y, Decaestecker J, Bhandari P, Ell C, Griffin SM, Attwood S, Barr H, Allen J, Ferguson MK, Moayyedi P, Jankowski JAZ. Consensus statements for management of Barrett's dysplasia and early-stage esophageal adenocarcinoma, based on a Delphi process. Gastroenterology 2012; 143(2): 336-346. (AMC)

85. Bennink RJ, Tulchinsky M, de Graaf W, Kadry Z, van Gulik TM. Liver function testing with nuclear medicine techniques is coming of age. Seminars In Nuclear Medicine 2012; 42(2): 124-137. (AMC)

86. Benson VS, Atkin WS, Green J, Nadel MR, Patnick J, Smith RA, Villain P. Toward standardizing and reporting colorectal cancer screening indicators on an international level: The International Colorectal Cancer Screening Network. International Journal Of Cancer 2012; 130(12): 2961-2973. (AMC)

87. Bergamo A, Gaiddon C, Schellens JH, Beijnen JH, Sava G. Approaching tumour therapy beyond platinum drugs: status of the art and perspectives of ruthenium drug candidates. J Inorg Biochem 2012; 106: 90-9 (NKI)

88. Bergman AM. Cabazitaxel: de grote stap voorwaarts bij chemotherapie voor castratieresistent prostaatcarcinoom (CRPC)? Tijdschrift voor Urologie 2012; 2: 45-52 (NKI)

89. Bergman JJGHM, Corley DA. Barrett's esophagus: who should receive ablation and how can we get the best results? Gastroenterology 2012; 143(3): 524-526. (AMC)

90. Bergman JJGHM, Vieth M, Fitzgerald RC. Let's not jump to conclusions regarding low-grade dysplasia in Barrett's esophagus. Gastroenterology 2012; 142(5): e18-9; author reply e19-20. (AMC)

91. Berkers CR, Leestemaker Y, et al. Probing the specificity and activity profiles of the proteasome inhibitors bortezomib and delanzomib. Mol Pharm 2012: 9: 1126-35 (NKI)

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119. Bissonnette JP, Balter PA, Dong L, Langen KM, Lovelock DM, Miften M, Moseley DJ, Pouliot J, Sonke JJ, Yoo S. Quality assurance for image-guided radiation therapy utilizing CT-based technologies: a report of the AAPM TG- 179. Med Phys 2012; 39: 1946-63 (NKI)

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124. Bleeker MCG, Meijer CJLM, Berkhof J. Follow-up after treatment for cervical intraepithelial neoplasia. British Medical Journal 2012; 345: . (VUmc)

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129. Bluekens AMJ, Holland R, Karssemeijer N, Broeders MJM, den Heeten GJ. Comparison of digital screening mammography and screen-film mammography in the early detection of clinically relevant cancers: a multicenter study. Radiology 2012; 265(3): 707-714. (AMC)

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139. Boettcher S, Ziegler P, Schmid MA, Takizawa H, Van Rooijen N, Kopf M, Heikenwalder M, Manz MG. Cutting Edge: LPS-Induced Emergency Myelopoiesis Depends on TLR4-Expressing Nonhematopoietic Cells. J Immunol 2012; 188: 5824-5828. (VUmc)

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144. Bongers EM, Dahele MR, Slotman BJ, Senan S, Bot JC. Proton Stereotactic Body Radiation Therapy for Clinically Challenging Cases of Centrally and Superiorly Located Stage I Non-Small-Cell Lung Cancer: in Regards to Register et Al. Int J Radiat Oncol Biol Phys 2011;89:1015-1022. International Journal of Radiation Oncology Biology Physics 2012; 82: 492. (VUmc)

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146. Bongers ML, Hogervorst JGF, Schouten LJ, Goldbohm RA, Schouten HC, van den Brandt PA. Dietary Acrylamide Intake and the Risk of Lymphatic Malignancies: The Netherlands Cohort Study on Diet and Cancer. PloS one 2012; 7: . (VUmc)

147. Bontkes HJ, Ruben JM, Alhan C, Westers TM, Ossenkoppele GJ, van de Loosdrecht AA. Azacitidine differentially affects CD4(pos) T-cell polarization in vitro and in vivo in high risk myelodysplastic syndromes. Leukemia Research 2012; 36: 921-930. (VUmc)

148. Boogerd W, Groeneveld F, Linn S, Baars JW, Brandsma D, van Tinteren H. Chemotherapy as primary treatment for brain metastases from breast cancer: analysis of 115 one year survivors. J Cancer Res Clin Oncol. 2012: 138: 1395-1403 (NKI)

149. Boone J, Bex A, Prevoo W. Percutaneous radiofrequency ablation of a small renal mass complicated by appendiceal perforation. Cardiovasc Intervent Radiol 2012; 35: 695-9 (NKI)


150. Boonstra K, van Erpecum KJ, van Nieuwkerk KMJ, Drenth JPH, Poen AC, Witteman BJM, Tuynman HARE, Beuers U, Ponsioen CY. Primary sclerosing cholangitis is associated with a distinct phenotype of inflammatory bowel disease. Inflammatory Bowel Diseases 2012; 18: 2270-2276. (VUmc)

151. Boparai KS, Reitsma JB, Dekker E. Hyperplastic polyposis syndrome and the risk of colorectal cancer response. GUT 2012; 61(3): 471-472. (AMC)

152. Borel F, Han R, Visser A, Petry H, van Deventer SJH, Jansen PLM, Konstantinova P. Adenosine triphosphate-binding cassette transporter genes up-regulation in untreated hepatocellular carcinoma is mediated by cellular microRNAs. Hepatology 2012; 55: 821-832. (VUmc)

153. Borensztajn K, Duitman J, Brüggemann LW, Spek CA. Protease-activated receptor-4 deficiency does not protect against bleomycin-induced pulmonary fibrosis in mice. European Respiratory Journal 2012; 40(4): 1056-1057. (AMC)

154. Borovski T, Beke P, van Tellingen O, Rodermond HM, Verhoeff JJ, Lascano V, Daalhuisen JB, Medema JP, and Sprick MR. Therapy-resistant tumor microvascular endothelial cells contribute to treatment failure in glioblastoma multiforme. Oncogene 2012 (NKI)

155. Borst P. Cancer drug pan-resistance: pumps, cancer stem cells, quiescence, epithelial to mesenchymal transition, blocked cell death pathways, persisters or what? Open Biology 2012; 2(5): 120066-. (AMC/NKI)

156. Borst P. Cancer drug pan-resistance: pumps, cancer stem cells, quiescence, epithelial to mesenchymal transition, blocked cell death pathways, persisters or what? Open Biol 2012; 2: 120066 (NKI)

157. Bosch LJW, Mongera S, Terhaar Sive Droste JS, Oort FA, van Turenhout ST, Penning MT, Louwagie J, Mulder CJJ, van Engeland M, Carvalho B, Meijer GA. Analytical sensitivity and stability of DNA methylation testing in stool samples for colorectal cancer detection. Cell Oncol 2012; 35: 309-315. (VUmc)

158. Bosch LJW, Oort FA, Neerincx M, Khalid-de Bakker CAJ, Droste JSTS, Melotte V, Jonkers DMAE, Masclee AAM, Mongera S, Grooteclaes M, Louwagie J, van Criekinge W, Coupe VMH, Mulder CJ, van Engeland M, Carvalho B, Meijer GA. DNA Methylation of Phosphatase and Actin Regulator 3 Detects Colorectal Cancer in Stool and Complements FIT. Cancer Prevention Research 2012; 5: 464-472. (VUmc)

159. Boshuizen R, Kuhn P, van den Heuvel M. Circulating tumor cells in non-small cell lung carcinoma. J Thorac Dis 2012; 4: 456-8 (NKI)

160. Boshuizen RC, Besnard APE, Boot H, van den Heuvel MM. Kortademigheid en hoestklachten na radiofrequency ablation of liver metastases- Dyspnea and coughing after radiofrequency ablation of liver metastases. Ned Tijdschr Oncol 2012; 9: 77-80 (NKI)

161. Boshuizen RC, Vincent AD, Kunst PW, Burgers JA, van den Heuvel MM. Talc Instillation Consensus Aids Differentiating Successful from Unsuccessful Pleurodesis: A Survey on the Interpretation of Pleural Approximation after Chest Tube Placement. Respiration. 2012 (NKI)

162. Boss DS, Glen H, Beijnen JH, Keesen M, Morrison R, Tait B, Copalu W, Mazur A, Wanders J, O'Brien JP, Schellens JH, Evans TR. A phase I study of E7080, a multitargeted tyrosine kinase inhibitor, in patients with advanced solid tumours. Br J Cancer 2012; 106: 1598- 604 (NKI)

163. Bosschaart N, Aalders MCG, van Leeuwen TG, Faber DJ. Spectral domain detection in low-coherence spectroscopy. Biomedical Optics Express 2012; 3(9): 2263-2272. (AMC)

164. Bosschaart N, Kok JH, Newsum AM, Ouweneel DM, Mentink R, van Leeuwen TG, Aalders Maurice CG. Limitations and opportunities of transcutaneous bilirubin measurements. Pediatrics 2012; 129(4): 689-694. (AMC)

165. Bossini-Castillo L, Martin JE, Broen J, Gorlova O, Simeon CP, Beretta L, Vonk MC, Callejas JL, Castellvi I, Carreira P, Garcia-Hernandez FJ, Castro MF, Coenen MJH, Riemekasten G, Witte T, Hunzelmann N, Kreuter A, Distler JHW, Koeleman BP, Voskuyl AE, Schuerwegh AJ, Palm O, Hesselstrand R, Nordin A, Airo P, Lunardi C, Scorza R, Shiels P, van Laar JM, Herrick A, Worthington J, Denton C, Tan FK, Arnett FC, Agarwal SK, Assassi S, Fonseca C, Mayes MD, Radstake TRDJ, Martin J. A GWAS follow-up study reveals the association of the IL12RB2 gene with systemic sclerosis in Caucasian populations. Human Molecular Genetics 2012; 21: 926-933. (VUmc)

166. Bostrom PJ, Alkhateeb S, Trottier G, Athanasopoulos PZ, Mirtti T, Kortekangas H, et al. Sex differences in bladder cancer outcomes among smokers with advanced bladder cancer. BJU Int 2012; 109: 70-6 (NKI)

167. Bot I, Blank CU, Brandsma D. Clinical and radiological response of leptomeningeal melanoma after whole brain radiotherapy and ipilimumab. J Neurol 2012; 259: 1976-8 (NKI)

168. Both J, Wu T, Bras J, Schaap GR, Baas F, Hulsebos TJM. Identification of novel candidate oncogenes in chromosome region 17p11.2-p12 in human osteosarcoma. Plos One 2012; 7(1): e30907-. (AMC)

169. Bottai D, Di Luca M, Majlessi L, Frigui W, Simeone R, Sayes F, Bitter W, Brennan MJ, Leclerc C, Batoni G, Campa M, Brosch R, Esin S. Disruption of the ESX-5 system of Mycobacterium tuberculosis causes loss of PPE protein secretion, reduction of cell wall integrity and strong attenuation. Molecular Microbiology 2012; 83: 1195-1209. (VUmc)

170. Boudestein K, Kamps WA, Veerman AJP, Pieters R. Different Outcome in Older Children With Acute Lymphoblastic Leukemia With Different Treatment Protocols in the Netherlands. Pediatric Blood & Cancer 2012; 58: 17-22. (VUmc)

171. Boulter L, Govaere O, Bird TG, Radulescu S, Ramachandran P, Pellicoro A, Ridgway RA, Seo SS, Spee B, Van Rooijen N, Sansom OJ, Iredale JP, Lowell S, Roskams T, Forbes SJ. Macrophage-derived Wnt opposes Notch signaling to specify hepatic progenitor cell fate in chronic liver disease. Nature Medicine 2012; 18: 572-579. (VUmc)

172. Bouwman P, Jonkers J. The effects of deregulated DNA damage signalling on cancer chemotherapy response and resistance. Nat Rev Cancer 2012; 12: 587-98 (NKI)

173. Braakhuis BJM, Brakenhoff RH, Leemans CR. Treatment choice for locally advanced head and neck cancers on the basis of risk factors: biological risk factors. Annals of Oncology 2012; 23: 173-177. (VUmc)

174. Braam KI, Overbeek A, Kaspers GJL, Ronckers CM, Schouten-van Meeteren AYN, van Dulmen-den Broeder E, Veening MA. Malignant melanoma as second malignant neoplasm in long-term childhood cancer survivors: a systematic review. Pediatric Blood & Cancer 2012; 58(5): 665-674. (AMC/VUmc)

175. Braamse AMJ, Gerrits MMJG, van Meijel B, Visser O, van Oppen P, Boenink AD, Cuijpers P, Huijgens PC, Beekman ATF, Dekker J. Predictors of health-related quality of life in patients treated with auto- and allo-SCT for hematological malignancies. Bone Marrow Transplantation 2012; 47: 757-769. (VUmc)

176. Bradshaw AC, Coughlan L, Miller AM, Alba R, Van Rooijen N, Nicklin SA, Baker AH. Biodistribution and inflammatory profiles of novel penton and hexon double-mutant serotype 5 adenoviruses. Journal of Controlled Release 2012; 164: 394-402. (VUmc)

177. Bratton DJ, Nunn AJ, Wojnarowska F, Kirtschig G, Sandell A, Williams HC. The value of the pragmatic-explanatory continuum indicator summary wheel in an ongoing study: the bullous pemphigoid steroids and tetracyclines study. Trials 2012; 13: . (VUmc)


178. Bremmer RH, de Bruin KG, van Gemert MJC, van Leeuwen TG, Aalders MCG. Forensic quest for age determination of bloodstains. Forensic Science International 2012; 216(1-3): 1-11. (AMC)

179. Brennan DJ, O’Connor DP, Laursen H, McGee SF, McCarthy S, Zagozdzon R, Rexhepaj E, Culhane AC, Martin FM, Duffy MJ, Landberg G, Ryden L, Hewitt SM, Kuhar MJ, Bernards R, Millikan RC, Crown JP, Jirstrom K, Gallagher WM. The cocaine- and amphetamineregulated transcript mediates ligandindependent activation of ERalpha, and is an independent prognostic factor in node-negative breast cancer. Oncogene 2012; 31: 3483-94 (NKI)

180. Brignole M, Menozzi C, Moya A, Andresen D, Blanc JJ, Krahn AD, Wieling W, Beiras X, Deharo JC, Russo V, Tomaino M, Sutton R. Pacemaker Therapy in Patients With Neurally Mediated Syncope and Documented Asystole Third International Study on Syncope of Uncertain Etiology (ISSUE-3) A Randomized Trial. Circulation 2012; 125(21): 2566-U254. (AMC)

181. Broers CJM, Gemke RJBJ, Weijerman ME, Kuik DJ, van Hoogstraten IMW, van Furth AM. Frequency of lower respiratory tract infections in relation to adaptive immunity in children with Down syndrome compared to their healthy siblings. Acta Paediatrica 2012; 101: 862-867. (VUmc)

182. Broers CJM, Gemke RJBJ, Weijerman ME, van der Sluijs KF, van Furth AM. Increased Pro-inflammatory Cytokine Production in Down syndrome Children Upon Stimulation with Live Influenza A Virus. Journal of Clinical Immunology 2012; 32: 323-329. (VUmc)

183. Brölmann FE, Groenewold MD, Spijker R, van der Hage JA, Ubbink DT, Vermeulen H. Does evidence permeate all surgical areas equally? Publication trends in wound care compared to breast cancer care: a longitudinal trend analysis. World J Surg 2012; 36: 2021-7 (NKI)

184. Bromberg JE, Doorduijn JK, Baars JW, van Imhoff GW, Enting R, van den Bent MJ. Acute painful lumbosacral paresthesia after intrathecal rituximab. J Neurol 2012; 259: 559-561 (NKI)

185. Bronkhorst IHG, Vu THK, Jordanova ES, Luyten GPM, van der Burg SH, Jager MJ. Different Subsets of Tumor-Infiltrating Lymphocytes Correlate with Macrophage Influx and Monosomy 3 in Uveal Melanoma. Investigative Ophthalmology & Visual Science 2012; 53: 5370-5378. (VUmc)

186. Brouns EREA, Bloemena E, Belien JAM, Broeckaert MAM, Aartman IHA, van der Waal I. DNA ploidy measurement in oral leukoplakia: Different results between flow and image cytometry. Oral Oncology 2012; 48: 636-640. (VUmc)

187. Brouwer CL, Steenbakkers RJ, van den Heuvel E, Duppen JC, Navran A, Bijl HP, Chouvalova O, Burlage FR, Meertens H, Langendijk JA, van ‘t Veld AA. 3D variation in delineation of head and neck organs at risk. Radiat Oncol 2012; 7: 32 (NKI)

188. Brouwer OR, Buckle T, Bunschoten A, Kuil J, Vahrmeijer AL, Wendler T, Valdés-Olmos RA, van der Poel HG, van Leeuwen FW. Image navigation as a means to expand the boundaries of fluorescence-guided surgery. Phys Med Biol 2012; 57: 3123-36 (NKI)

189. Brouwer OR, Buckle T, Vermeeren L, Klop WM, Balm AJ, van der Poel HG, van Rhijn BW, Horenblas S, Nieweg OE, van Leeuwen FW, Valdés Olmos RA. Comparing the hybrid fluorescentradioactive tracer indocyanine green-99mTc-nanocolloid with 99mTc-nanocolloid for sentinel node identification: a validation study using lymphoscintigraphy and SPECT/CT. J Nucl Med 2012; 53: 1034-40 (NKI)

190. Brouwer OR, Donker M, Woerdeman LA, Vrancken Peeters MJ. Local recurrence after skin-sparing mastectomy. Ned Tijdschr Geneeskd 2012; 156: A4692 (NKI)

191. Brouwer OR, Klop WM, Buckle T, Vermeeren L, van den Brekel MW, Balm AJ, Nieweg OE, Valdés Olmos RA, van Leeuwen FW. Feasibility of sentinel node biopsy in head and neck melanoma using a hybrid radioactive and fluorescent tracer. Ann Surg Oncol 2012; 19: 1988-94 (NKI)

192. Brouwer OR, van Leeuwen FWB, van der Poel HG, Horenblas S, Valdés Olmos RA, Meinhardt W. De schildwachtklierprocedure bij prostaatkanker. Tijdschr Urol 2012; 2: 84-91 (NKI)

193. Brouwer OR, Vermeeren L, van der Ploeg IM, Valdés Olmos RA, Loo CE, Pereira-Bouda LM, Smit F, Neijenhuis P, Vrouenraets BC, Sivro-Prndelj F, Jap-a-Joe SM, Borgstein PJ, Rutgers EJ, Oldenburg HS. Lymphoscintigraphy and SPECT/CT in multicentric and multifocal breast cancer: does each tumour have a separate drainage pattern? Results of a Dutch multicentre study (MULTISENT). Eur J Nucl Med Mol Imaging 2012; 39: 1137-43 (NKI)

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197. Bruijnen STG, van der Weijden MAC, Klein JP, Hoekstra OS, Boellaard R, van Denderen JC, Dijkmans BAC, Voskuyl AE, van der Horst-Bruinsma I, van der Laken CJ. Bone formation rather than inflammation reflects Ankylosing Spondylitis activity on PET-CT: a pilot study. Arthritis Research & Therapy 2012; 14: . (VUmc)

198. Bruinsma W, Raaijmakers JA, Medema RH. Switching Polo-like kinase-1 on and off in time and space. Trends Biochem Sci 2012; 37: 534-42 (NKI)

199. Buckle T, Brouwer OR, Valdes Olmos RA, van der Poel HG, van Leeuwen FWB. Relationship between intraprostatic tracer deposits and sentinel lymph node mapping in prostate cancer patients. J Nucl Med 2012; 53: 1026-33 (NKI)

200. Buckle T, van Berg NS, Kuil J, Bunschoten A, Oldenburg J, Borowsky AD, Wesseling J, Masada R, Oishi S, Fujii N, van Leeuwen FW. Noninvasive longitudinal imaging of tumor progression using an (111)indium labeled CXCR4 peptide antagonist. Am J Nucl Med Mol Imaging 2012; 2: 99-109 (NKI)

201. Bucuras V, Gopalakrishnam G, Wolf Jr. JS, Sun Y, Bianchi G, Erdogru T, de la Rosette J. The Clinical Research Office of the Endourological Society Percutaneous Nephrolithotomy Global Study: nephrolithotomy in 189 patients with solitary kidneys. Journal Of Endourology 2012; 26(4): 336-341. (AMC)

202. Buffart LM, Thong MSY, Schep G, Chinapaw MJM, Brug J, van de Poll-Franse L. Self-Reported Physical Activity: Its Correlates and Relationship with Health-Related Quality of Life in a Large Cohort of Colorectal Cancer Survivors. PloS one 2012; 7: . (VUmc)

203. Buffart LM, van Uffelen JG, Riphagen I, Brug J, van Mechelen W, Brown WJ, Chinapaw MJ. Physical and psychosocial benefits of yoga in cancer patients and survivors, a systematic review and meta-analysis of randomized controlled trials. BMC Cancer 2012; 12: 559. (VUmc)


204. Buffart TE, Carvalho B, van Grieken NCT, van Wieringen AN, Tijssen M, Kranenbarg EMK, Verheul HMW, Grabsch HI, Ylstra B, van de Velde CJH, Meijer GA. Losses of Chromosome 5q and 14q Are Associated with Favorable Clinical Outcome of Patients with Gastric Cancer. Oncologist 2012; 17: 653-662. (VUmc)

205. Buis DR, Bot JCJ, Barkhof F, Knol DL, Lagerwaard FJ, Slotman BJ, Vandertop WP, van den Berg R. The Predictive Value of 3D Time-of-Flight MR Angiography in Assessment of Brain Arteriovenous Malformation Obliteration after Radiosurgery. American Journal of Neuroradiology 2012; 33: 232-238. (VUmc)

206. Buis DR, van der Valk P, de Witt Hamer PC. Subcutaneous tumor seeding after biopsy in gliomatosis cerebri. Journal of Neuro-Oncology 2012; 106: 431-435. (VUmc)

207. Büller NVJA, Rosekrans SL, Westerlund J , van den Brink GR. Hedgehog signaling and maintenance of homeostasis in the intestinal epithelium. Physiology 2012; 27(3): 148-155. (AMC)

208. Bulten BF, van der Palen RLF, van Laarhoven HWM, Kapusta L, Mavinkurve-Groothuis AMC, de Geus-Oei L. Interobserver variability of heart-to-mediastinum ratio in I-123 MIBG sympathetic imaging. Current Cardiology Reports 2012; 14(4): 389-90 (author reply 391). (AMC)

209. Bultink IEM, Vis M, van der Horst-Bruinsma I, Lems WF. Inflammatory rheumatic disorders and bone. Current Rheumatology Reports 2012; 14: 224-230. (VUmc)

210. Bultink IEM. Osteoporosis and fractures in systemic lupus erythematosus. Arthritis Care & Research 2012; 64: 2-8. (VUmc)

211. Bunders MJ, van der Loos CM, Klarenbeek PL, van Hamme JL, Boer K, Wilde JCH, de Vries N, van Lier RAW, Kootstra N, Pals ST, Kuijpers TW. Memory CD4(+)CCR5(+) T cells are abundantly present in the gut of newborn infants to facilitate mother-to-child transmission of HIV-1. Blood 2012; 120(22): 4383-4390. (AMC)

212. Bundred NJ, Kenemans P, Yip CH, Beckmann MW, Foidart JM, Sismondi P, von Schoultz B, Vassilopoulou-Sellin R, El Galta R, Van Lieshout E, Mol-Arts M, Planellas J, Kubista E. Tibolone increases bone mineral density but also relapse in breast cancer survivors: LIBERATE trial bone substudy. Breast Cancer Research 2012; 14: . (VUmc)

213. Bunschoten A, Buckle T, Kuil J, Nieweg OE, van Leeuwen FWB. Targeted noncovalent self-assembled nanoparticles based on human serum albumin. Biomaterials 2012; 33: 867-75 (NKI)

214. Bunt J, Hasselt NE, Zwijnenburg DA, Hamdi M, Koster J, Versteeg R, Kool M.: OTX2 directly activates cell cycle genes and inhibits differentiation in medulloblastoma cells. International Journal Of Cancer 2012; 131(2): E21-E32. (AMC)

215. Burns KE, McAllister FE,, et al. Mycobacterium tuberculosis prokaryotic ubiquitin-like proteindeconjugating enzyme is an unusual aspartate amidase. J Biol Chem 2012: 287: 37522-37529 (NKI)

216. Bus MT, Cordeiro ER, Anastasiadis A, Klioueva NM, de la Rosette JJ, de Reijke TM. Urothelial carcinoma in both adnexa following perforation during transurethral resection of a non-muscle-invasive bladder tumor: a case report and literature review. Expert Review Of Anticancer Therapy 2012; 12(12): 1529-1536. (AMC)

217. Busard MPH, Mijatovic V, L³chinger AM, Bleeker MCG, van den Pieters-van den Bos, Schats R, Van Kuijk C, Hompes PGA, van Waesberghe JHTM. MR imaging of bladder endometriosis and its relationship with the anterior uterine wall: Experience in a tertiary referral centre. European Journal of Radiology 2012; 81: 2106-2111. (VUmc)

218. Busard MPH, Pieters-van den Bos I, Mijatovic V, Van Kuijk C, Bleeker MCG, van Waesberghe JHTM. Evaluation of MR diffusion-weighted imaging in differentiating endometriosis infiltrating the bowel from colorectal carcinoma. European Journal of Radiology 2012; 81: 1376-1380. (VUmc)

219. Busard MPH, van der Houwen LEE, Bleeker MCG, van den Bos ICP, Cuesta MA, Van Kuijk C, Mijatovic V, Hompes PGA, van Waesberghe JHTM. Deep infiltrating endometriosis of the bowel: MR imaging as a method to predict muscular invasion. Abdominal Imaging 2012; 37: 549-557. (VUmc)

220. Buskermolen S, Langius JAE, Kruizenga HM, Ligthart-Melis GC, Heymans MW, Verheul HMW. Weight Loss of 5% or More Predicts Loss of Fat-Free Mass During Palliative Chemotherapy in Patients With Advanced Cancer: A Pilot Study. Nutrition and Cancer-an International Journal 2012; 64: 826-832. (VUmc)

221. Caan MWA, Shahand S, Vos FM, van Kampen AHC, Olabarriaga SD. Evolution of grid-based services for Diffusion Tensor Image analysis. Future Generation Computer Systems 2012; 28(8): 1194-1204. (AMC)

222. Caillat C, Perrakis A. Cdt1 and geminin in DNA replication initiation. Subcellular biochemistry 2012; 62: 71-87 (NKI) 223. Canet MJ, Hardwick RN, Lake AD, Kopplin MJ, Scheffer GL, Klimecki WT, Gandolfi AJ, Cherrington NJ. Altered arsenic

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224. Canfell K, Chesson H, Kulasingam SL, Berkhof J, Diaz M, Kim JJ. Modeling preventative strategies against human papillomavirus-related disease in developed countries. Vaccine 2012; 30: F157-F167. (VUmc)

225. Capelle LG, den Hoed CM, de Vries AC, Biermann K, Casparie MK, Meijer GA, Kuipers EJ. Premalignant gastric lesions in patients with gastric mucosa-associated lymphoid tissue lymphoma and metachronous gastric adenocarcinoma: a case-control study. European Journal of Gastroenterology & Hepatology 2012; 24: 42-47. (VUmc)

226. Cardillo G, Rea F, Lucchi M, Paul MA, Margaritora S, Carleo F, Marulli G, Mussi A, Granone P, Graziano P. Primary Neuroendocrine Tumors of the Thymus: A Multicenter Experience of 35 Patients. Annals of Thoracic Surgery 2012; 94: 241-246. (VUmc)

227. Carvalho B, Sillars-Hardebol AH, Postma C, Mongera S, Droste JTS, Obulkasim A, van de Wiel M, van Criekinge W, Ylstra B, Fijneman RJA, Meijer GA. Colorectal adenoma to carcinoma progression is accompanied by changes in gene expression associated with ageing, chromosomal instability, and fatty acid metabolism. Cell Oncol 2012; 35: 53-63. (VUmc)

228. Carvalho J, van Grieken NC, Pereira PM, Sousa S, Tijssen M, Buffart TE, Diosdado B, Grabsch H, Santos MAS, Meijer GA, Seruca R, Carvalho B, Oliveira C. Lack of microRNA-101 causes E-cadherin functional deregulation through EZH2 up-regulation in intestinal gastric cancer. Journal of Pathology 2012; 228: 31-44. (VUmc)

229. Castellsague X, Diaz M, Vaccarella S, de Sanjose S, Munoz N, Herrero R, Franeschi S, Meijer CJLM, Bosch FX. Intrauterine Device Use, Cervical Infection With Human Papillomavirus, and Risk of Cervical Cancer: A Pooled Analysis of 26 Epidemiological Studies. Obstetrical & Gynecological Survey 2012; 67: 353-355. (VUmc)

230. Castien RF, van der Windt DAWM, Blankenstein AH, Heymans MW, Dekker J. Clinical variables associated with recovery in patients with chronic tension-type headache after treatment with manual therapy. Pain 2012; 153: 893-899. (VUmc)

231. Castillo D, Puig S, Iglesias M, Seoane A, de Bolós C, Munitiz V, Parrilla P, Comerma L, Poulsom R, Krishnadath KK, Grande L, Pera M. Activation of the BMP4 pathway and early expression of CDX2 characterize non-specialized columnar metaplasia in a human model of Barrett's esophagus. journal of gastrointestinal surgery 2012; 16(2): 227-37 (discussion 237). (AMC)


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233. Cazander G, Schreurs MWJ, Renwarin L, Dorresteijn C, Hamann D, Jukema GN. Maggot excretions affect the human complement system. Wound Repair and Regeneration 2012; 20: 879-886. (VUmc)

234. Celie JWAM, Katta KK, Adepu S, Melenhorst WBWH, Reijmers RM, Slot EM, Beelen RHJ, Spaargaren M, Ploeg RJ, Navis G, Homan van der Heide JJ, van Dijk MCRF, van Goor H, van den Born J. Tubular epithelial syndecan-1 maintains renal function in murine ischemia/reperfusion and human transplantation. Kidney International 2012; 81(7): 651-661. (AMC/VUmc)

235. Cenit MC, Simeon CP, Vonk MC, Callejas-Rubio JL, Espinosa G, Carreira P, Blanco FJ, Narvaez J, Tolosa C, Roman-Ivorra JA, Gomez-Garcia I, Garcia-Hernandez FJ, Gallego M, Garcia-Portales R, Egurbide MV, Fonollosa V, de la Pena PG, Lopez-Longo FJ, Gonzalez-Gay MA, Hesselstrand R, Riemekasten G, Witte T, Voskuyl AE, Schuerwegh AJ, Madhok R, Fonseca C, Denton C, Nordin A, Palm O, van Laar JM, Hunzelmann N, Distler JHW, Kreuter A, Herrick A, Worthington J, Koeleman BP, Radstake TRDJ, Martin J. Influence of the IL6 Gene in Susceptibility to Systemic Sclerosis. Journal of Rheumatology 2012; 39: 2294-2302. (VUmc)

236. Cernohorsky P, de Bruin DM, van Herk M, Bras J, Faber DJ, Strackee SD, van Leeuwen TG. In-situ imaging of articular cartilage of the first carpometacarpal joint using co-registered optical coherence tomography and computed tomography. Journal Of Biomedical Optics 2012; 17(6): 060501-. (AMC/NKI)

237. Chai X, van Herk M, Betgen A, Bel A. Automatic bladder segmentation on CBCT for multiple plan ART of bladder cancer using a patientspecific bladder model. Phys Med Biol 2012; 57: 3945-62 (NKI/AMC)

238. Chai X, van Herk M, Betgen A, Hulshof M, Bel A. Semiautomatic bladder segmentation on CBCT using a population-based model for multiple-plan ART of bladder cancer. Physics In Medicine And Biology 2012; 57(24): N525-N541. (AMC/NKI)

239. Chai X, van Herk M, Hulshof MC, Bel A. A voxel-based finite element model for the prediction of bladder deformation. Med Phys 2012; 39: 55-65 (NKI/AMC)

240. Chakraverty S, Flood K, Kessel D, McPherson S, Nicholson T, Ray Jr. CE, Robertson I, van Delden OM. CIRSE guidelines: quality improvement guidelines for endovascular treatment of traumatic hemorrhage. Cardiovascular And Interventional Radiology 2012; 35(3): 472-482. (AMC)

241. Cheebsumon P, Boellaard R, de Ruysscher D, van Elmpt W, van Baardwijk A, Yaqub M, Hoekstra OS, Comans EF, Lammertsma AA, van Velden FH. Assessment of tumour size in PET/CT lung cancer studies: PET- and CT-based methods compared to pathology. Eur J Nucl Med Mol Imaging 2012; 2: 56. (VUmc)

242. Chen F, Liu ZG, Wu WH, Rozo C, Bowdridge S, Millman A, Van Rooijen N, Urban JF, Wynn TA, Gause WC. An essential role for T(H)2-type responses in limiting acute tissue damage during experimental helminth infection. Nature Medicine 2012; 18: 260-266. (VUmc)

243. Chen JK, Ghasri P, Aguilar G, van Drooge AM, Wolkerstorfer A, Kelly KM, Heger M: An overview of clinical and experimental treatment modalities for port wine stains. Journal Of The American Academy Of Dermatology 2012; 67(2): 289-304. (AMC)

244. Chen W, Stroom J, Sonke JJ, Bartelink H, Schmitz AC, Gilhuijs KG. Impact of negative margin width on local recurrence in breast conserving therapy. Radiother Oncol 2012; 104: 148-54 (NKI)

245. Cheng S, Kirtschig G, Cooper S, Thornhill M, Leonardi-Bee J, Murphy R. Interventions for erosive lichen planus affecting mucosal sites. Cochrane Database Syst Rev 2012; 2: . (VUmc)

246. Cherry MG, Frisch A, Hillen MA, Martinelli V, Pype PF, Scholl I, Schwenessen N, Gudzune KA. Advice for junior researchers--lessons learned from the 2011 Y-EACH Junior Investigators' Workshop. Patient Education And Counseling 2012: 89(1): 214-215. (AMC)

247. Chi CC, Kirtschig G, Baldo M, Lewis F, Wang SH, Wojnarowska F. Systematic review and meta-analysis of randomized controlled trials on topical interventions for genital lichen sclerosus. Journal of the American Academy of Dermatology 2012; 67: 305-312. (VUmc)

248. Chikhovskaya JV, Jonker MJ, Meissner A, Breit TM, Repping S, van Pelt AMM. Human testis-derived embryonic stem cell-like cells are not pluripotent, but possess potential of mesenchymal progenitors. Human Reproduction 2012; 27(1): 210-221. (AMC)

249. Chinapaw MJM, Buffart LM, van Mechelen W, Schep G, Aaronson NK, van Harten WH, Stuiver MM, Kersten MJ, Nollet F, Kaspers GJK, van Dulmen-den Broeder E, Huisman J, Takken T, van Tulder M, Brug J. Alpe d’HuZes Cancer Rehabilitation (A-CaRe) research: Four randomized controlled exercise trials and economic evaluations in cancer patients and survivors. Int J Behav Med 2012; 19: 143-56 (AMC/NKI/VUmc)

250. Choi G, Meijer SL, Hazenberg MD. Disseminated bread yeast fungaemia in a baker's wife with acute myeloid leukaemia. British Journal Of Haematology 2012; 158(3): 298-. (AMC)

251. Choundry N, Petry F, Van Rooijen N, McDonald VK. A Protective Role for Interleukin 18 in Interferon gamma-Mediated Innate Immunity to Cryptosporidium parvum That Is Independent of Natural Killer Cells. J Infect Dis 2012; 206: 117-124. (VUmc)

252. Christerson L, Bom RJM, Bruisten SM, Yass R, Hardick J, Bratt G, Gaydos CA, Morre SA, Herrmann B. Chlamydia trachomatis Strains Show Specific Clustering for Men Who Have Sex with Men Compared to Heterosexual Populations in Sweden, the Netherlands, and the United States. Journal of Clinical Microbiology 2012; 50: 3548-3555. (VUmc)

253. Christianen MEMC, Schilstra C, Beetz I, Muijs CT, Chouvalova O, Burlage FR, Doornaert P, Koken PW, Leemans CR, Rinkel RNPM, de Bruijn MJ, de Bock GH, Roodenburg JLN, van der Laan BFAM, Slotman BJ, Verdonck-de Leeuw IM, Bijl HP, Langendijk JA. Predictive modelling for swallowing dysfunction after primary (chemo)radiation: Results of a prospective observational study. Radiotherapy and Oncology 2012; 105: 107-114. (VUmc)

254. Ciampricotti M, Hau CS, Doornebal CW, Jonkers J, de Visser KE. Chemotherapy response of spontaneous mammary tumors is independent of the adaptive immune system. Nat Med 2012; 18: 344-46 (NKI)

255. Cibula D, Abu-Rustum NR, Dusek L, Slama J, Zikán M, Zaal A, Sevcik L, Kenter G, Querleu D, Jach R, Bats A, Dyduch G, Graf P, Klat J, Meijer CJLM, Mery E, Verheijen R, Zweemer RP. Bilateral ultrastaging of sentinel lymph node in cervical cancer: Lowering the false-negative rate and improving the detection of micrometastasis. Gynecologic Oncology 2012; 127(3): 462-466. (AMC/NKI/VUmc)


256. Cibula D, Abu-Rustum NR, Dusek L, Zikán M, Zaal A, Sevcik L, Kenter GG, Querleu D, Jach R, Bats AS, Dyduch G, Graf P, Klat J, Lacheta J, Meijer CJ, Mery E, Verheijen R, Zweemer RP. Prognostic significance of low volume sentinel lymph node disease in earlystage cervical cancer. Gynecol Oncol 2012; 124: 496-501 (NKI/VUmc)

257. Clarke K, Taremi M, Dahele M, Freeman M, Fung SR, Franks K, Bezjak A, Brade A, Cho J, Hope A, Sun A. Stereotactic body radiotherapy (SBRT) for non-small cell lung cancer (NSCLC): Is FDG-PET a predictor of outcome?. Radiotherapy and Oncology 2012; 104: 62-66. (VUmc)

258. Cnossen IC, de Bree R, Rinkel RNPM, Eerenstein SEJ, Rietveld DHF, Doornaert P, Buter J, Langendijk JA, Leemans CR, Verdonck-de Leeuw IM. Computerized monitoring of patient-reported speech and swallowing problems in head and neck cancer patients in clinical practice. Supportive Care in Cancer 2012; 20: 2925-2931. (VUmc)

259. Coenen EA, Driessen EMC, Zwaan CM, Stary J, Baruchel A, de Haas V, De Bont ESJM, Reinhardt D, Kaspers GJL, rentsen-Peters STCJ, Meyer C, Marschalek R, Pieters R, Stam RW, van den Heuvel-Eibrink M. CBL mutations do not frequently occur in paediatric acute myeloid leukaemia. British Journal of Haematology 2012; 159: 577-584. (VUmc)

260. Collin P, Rondonotti E, Lundin KEA, Spada C, Keuchel M, Kaukinen K, Franchis RDE, Jacobs MAJM, Villa F, Mulder CJJ. Video capsule endoscopy in celiac disease: Current clinical practice. Journal of Digestive Diseases 2012; 13: 94-99. (VUmc)

261. Cong SY, Pepers BA, Zhou TT, Kerkdijk H, Roos RA, van Ommen GJ, Dorsman JC. Huntingtin with an expanded polyglutamine repeat affects the Jab1-p27(Kip1) pathway. Neurobiology of Disease 2012; 46: 673-681. (VUmc)

262. Coombes JL, Han SJ, Van Rooijen N, Raulet DH, Robey EA. Infection-Induced Regulation of Natural Killer Cells by Macrophages and Collagen at the Lymph Node Subcapsular Sinus. Cell Reports 2012; 2: 124-135. (VUmc)

263. Coquet JM, Middendorp S*, van der Horst G*, Kind J, Veraar EAM, Xiao Y, Jacobs H, Borst J. The CD27 and CD70 costimulatory pathway inhibits effector function of T helper 17 cells and attenuates associated autoimmunity. Immunity 2013; 38: 53-65 (NKI)

264. Cordeiro ER, Cathelineau X, Thüroff S, Marberger M, Crouzet S, de La Rosette JJMCH. High-intensity focused ultrasound (HIFU) for definitive treatment of prostate cancer. BJU International 2012; 110(9): 1228-1242. (AMC)

265. Cormio L, Perrone A, Di Fino G, Ruocco N, de Siati M, de la Rosette J, Carrieri G. TachoSil(®) sealed tubeless percutaneous nephrolithotomy to reduce urine leakage and bleeding: outcome of a randomized controlled study. Journal Of Urology 2012; 188(1): 145-150. (AMC)

266. Cornel MC, Gille JJP, Loeber JG, Langen AMMV, nkert-Roelse J, Bolhuis PA. Improving test properties for neonatal cystic fibrosis screening in the Netherlands before the nationwide start by May 1st 2011. Journal of Inherited Metabolic Disease 2012; 35: 635-640. (VUmc)

267. Cornelissen JJ, Breems D, van Putten WL, Gratwohl AA, Passweg JR, Pabst T, Maertens J, Beverloo H, Kooy MvM, Wijermans PW, Biemond BJ, Vellenga E, Verdonck LF, Ossenkoppele GJ, Lowenberg B. Comparative Analysis of the Value of Allogeneic Hematopoietic Stem-Cell Transplantation in Acute Myeloid Leukemia With Monosomal Karyotype Versus Other Cytogenetic Risk Categories. J Clin Oncol 2012; 30: 2140-2146. (VUmc/AMC)

268. Cornelissen JJ, Gratwohl A, Schlenk RF, Sierra J, Bornhaeuser M, Juliusson G, Racil Z, Rowe JM, Russell N, Mohty M, Lowenberg B, Socie G, Niederwieser D, Ossenkoppele GJ. The European LeukemiaNet AML Working Party consensus statement on allogeneic HSCT for patients with AML in remission: an integrated-risk adapted approach. Nature Reviews Clinical Oncology 2012; 9: 579-590. (VUmc)

269. Cornero A, Acquaviva M, Fardin P, Versteeg R, Schramm A, Eva A, Bosco MC, Blengio F, Barzaghi S, Varesio L. Design of a multi-signature ensemble classifier predicting neuroblastoma patients' outcome. BMC Bioinformatics 2012; 13(Suppl. 4): S13-. (AMC)

270. Cornet I, Gheit T, Franceschi S, Vignat J, Burk RD, Sylla BS, Tommasino M, Clifford GM, Snijders PJF. Human Papillomavirus Type 16 Genetic Variants: Phylogeny and Classification Based on E6 and LCR. Journal of Virology 2012; 86: 6855-6861. (VUmc)

271. Cornet ME, Reinartz SM, Georgalas C, van Spronsen E, Fokkens WJ. The microdebrider, a step forward or an expensive gadget?. Rhinology 2012; 50(2): 191-198. (AMC)

272. Corver WE, Ruano D, Weijers K, den Hartog WCE, van Nieuwenhuizen MP, de Miranda N, van Eijk R, Middeldorp A, Jordanova ES, Oosting J, Kapiteijn E, Hovens G, Smit J, van Wezel T, Morreau H. Genome Haploidisation with Chromosome 7 Retention in Oncocytic Follicular Thyroid Carcinoma. PloS one 2012; 7: . (VUmc)

273. Couch FJ et al. Consortium of Investigators of Modifiers of BRCA1/2. Common variants at the 19p13.1 and ZNF365 loci are associated with ER subtypes of breast cancer and ovarian cancer risk in BRCA1 and BRCA2 mutation carriers. Cancer Epidemiol Biomarkers Prev. 2012 Apr; 21(4): 645-57 (NKI/AMC/VUmc)

274. Coughlan L, Bradshaw AC, Parker AL, Robinson H, White K, Custers J, Goudsmit J, Van Rooijen N, Barouch DH, Nicklin SA, Baker AH. Ad5:Ad48 Hexon Hypervariable Region Substitutions Lead to Toxicity and Increased Inflammatory Responses Following Intravenous Delivery. Molecular Therapy 2012; 20: 2268-2281. (VUmc)

275. Coughlan L, Vallath S, Gros A, Gimenez-Alejandre M, Van Rooijen N, Thomas GJ, Baker AH, Cascallo M, Alemany R, Hart IR. Combined Fiber Modifications Both to Target alpha(v)beta(6) and Detarget the Coxsackievirus-Adenovirus Receptor Improve Virus Toxicity Profiles In Vivo but Fail to Improve Antitumoral Efficacy Relative to Adenovirus Serotype 5. Human Gene Therapy 2012; 23: 960-979. (VUmc)

276. Coupe VM, Gonzalez-Barreiro L, Gutierrez-Berzal J, Melian-Boveda AL, Lopez-Rodriguez O, Alba-Dominguez J, Alba-Losada J. Transcriptional analysis of human papillomavirus type 16 in histological sections of cervical dysplasia by in situ hybridisation. Journal of Clinical Pathology 2012; 65: 164-170. (VUmc)

277. Coupe VMH, Bogaards JA, Meijer CJLM, Berkhof J. Impact of vaccine protection against multiple HPV types on the cost-effectiveness of cervical screening. Vaccine 2012; 30: 1813-1822. (VUmc)

278. Courrech Staal EF, Bloemendal K, Bloemer MC, Aleman BM, Cats A, van Sandick JW. Oesophageal cancer treatment in a tertiary referral hospital evaluated by indicators for quality of care. Eur J Surg Oncol 2012; 38: 150-6 (NKI)

279. Creutzig U, van den Heuvel-Eibrink M, Gibson B, Dworzak MN, Adachi S, de Bont E, Harbott J, Hasle H, Johnston D, Kinoshita A, Lehrnbecher T, Leverger G, Mejstrikova E, Meshinchi S, Pession A, Raimondi SC, Sung LL, Stary J, Zwaan CM, Kaspers GJL, Reinhardt D. Diagnosis and management of acute myeloid leukemia in children and adolescents: recommendations from an international expert panel. Blood 2012; 120: 3187-3205. (VUmc)

280. Criscitiello C, Azim HA, Jr., Schouten PC, Linn SC, Sotiriou C. Understanding the biology of triple-negative breast cancer. Ann Oncol 2012; 23 Suppl 6: vi13-18 (NKI)

281. Crolla RMPH, van der Laan L, Veen EJ, Hendriks Y, van Schendel C, Kluytmans J. Reduction of Surgical Site Infections after Implementation of a Bundle of Care. PloS one 2012; 7: . (VUmc)


282. Crombag MRBS, Huisman C, Kemper EM, Brüggemann RJM, Bijleveld YA. Posaconazole treatment in hematology patients: a pilot study of therapeutic drug monitoring. Therapeutic Drug Monitoring 2012; 34(3): 320-325. (AMC)

283. Cuesta MA, Biere SS, Henegouwen MI, van der Peet DL. Randomised trial, minimally invasive oesophagectomy versus oopen oesophagectomy for patients with resectable oesophageal cancer. J Thorac Dis 2012; 4: 462-464. (VUmc)

284. Cuesta MA, Biere SSAY, Henegouwen MIV, Hollmann MW, van der Peet DL. Minimally invasive versus open oesophagectomy for oesophageal cancer reply. Lancet 2012; 380: 885-886. (VUmc)

285. Cufer T, Cardoso F, Werutsky G, Bonnefoi H, Brain E, Cataliotti L, Dal Lago L, Delaloge S, Jassem J, van Tienhoven G, van't Veer L, Westenberg H, Marreaud S, Bogaerts J, Rutgers E, Cameron D. The EORTC Breast Cancer Group: major achievements of 50 years of research and future directions. EJC Supplements 2012; 10(1): 27-33. (AMC)

286. Czuczman MS, Fayad L, Delwail V, Cartron G, Jacobsen E, Kuliczkowski K, Link BK, Pinter-Brown L, Radford J, Hellmann A, Gallop-Evans E, Dirienzo CG, Goldstein N, Gupta I, Jewell RC, Lin TS, Lisby S, Schultz M, Russell CA, Hagenbeek A. Ofatumumab monotherapy in rituximab-refractory follicular lymphoma: results from a multicenter study. Blood 2012; 119(16): 3698-3704. (AMC)

287. da Silveira JC, Veeramachaneni DNR, Winger QA, Carnevale EM, Bouma GJ. Cell-Secreted Vesicles in Equine Ovarian Follicular Fluid Contain miRNAs and Proteins: A Possible New Form of Cell Communication Within the Ovarian Follicle. Biology of Reproduction 2012; 86: . (VUmc)

288. Daams M, Schuitema I, van Dijk BW, van Dulmen-den Broeder E, Veerman AJP, van den Bos C, de Sonneville LMJ. Long-term effects of cranial irradiation and intrathecal chemotherapy in treatment of childhood leukemia: a MEG study of power spectrum and correlated cognitive dysfunction. BMC Neurology 2012; 12: 84-. (AMC/VUmc)

289. Dackus GH, Loffeld SM, Loffeld RJ. Use of acid suppressive therapy more than 10 years after the endoscopic diagnosis of reflux esophagitis with specific emphasis to trademark and generic proton pump inhibitors. J Gastroenterol Hepatol 2012; 27: 368- 371 (NKI)

290. Daenen S, van der Holt B, Dekker AW, Willemze R, Rijneveld AW, Biemond BJ, Muus P, van de Loosdrecht AA, Schouten HC, van Marwijk Kooy M, Breems DA, Demuynck H, Maertens J, Wijermans PW, Wittebol S, de Klerk EW, Cornelissen JJ. Intensive chemotherapy to improve outcome in patients with acute lymphoblastic leukemia over the age of 40: a phase II study for efficacy and feasibility by HOVON. Leukemia 2012; 26(7): 1726-1729. (AMC/VUmc)

291. Dahele M, Verbakel W, Cuijpers J, Slotman B, Senan S. An analysis of patient positioning during stereotactic lung radiotherapy performed without rigid external immobilization. Radiotherapy and Oncology 2012; 104: 28-32. (VUmc)

292. Daleke MH, Ummels R, Bawono P, Heringa J, Vandenbroucke-Grauls CMJE, Luirink J, Bitter W. General secretion signal for the mycobacterial type VII secretion pathway. Proceedings of the National Academy of Sciences of the United States of America 2012; 109: 11342-11347. (VUmc)

293. Daleke MH, van der Woude AD, Parret AHA, Ummels R, Groot AM, Watson D, Piersma SR, Jimenez CR, Luirink J, Bitter W, Houben ENG. Specific Chaperones for the Type VII Protein Secretion Pathway. Journal of Biological Chemistry 2012; 287: 31939-31947. (VUmc)

294. Damhuis RA, Schroten C, Burgers JA. Population-based survival for malignant mesothelioma after introduction of novel chemotherapy. Eur Respir J 2012; 40: 185-9 (NKI)

295. Dashty M, Akbarkhanzadeh V, Zeebregts CJ, Spek CA, Sijbrands EJ, Peppelenbosch MP, Rezaee F. Characterization of coagulation factor synthesis in nine human primary cell types. Scientific Reports 2012; 2: 787-. (AMC/VUmc)

296. De Boer J, de Bois J, van Herk M, Sonke JJ. Influence of the number of elongated fiducial markers on the localization accuracy of the prostate. Phys Med Biol 2012; 57: 6211-26 (NKI)

297. de Boer MT, Klaase JM, Verhoef C, van Dam RM, van Gulik TM, Molenaar IQ, Bosscha K, Dejong CHC, van der Jagt EJ, Porte RJ. Fibrin sealant for prevention of resection surface-related complications after liver resection: a randomized controlled trial. Annals Of Surgery 2012; 256(2): 229-234. (AMC)

298. De Boer NKH, Jharap B, Seinen ML, van Bodegraven AA. Letter: thiopurines during pregnancy and intrauterine exposure to metabolites. Alimentary Pharmacology & Therapeutics 2012; 35: 964-965. (VUmc)

299. de Boer YS, Bouma G, Wattjes MP, Lips P, Mulder CJJ, van Nieuwkerk CMJ. A case of autoimmune hepatitis and bisphosphonate-related osteonecrosis of the jaw. Case Reports in Gastroenterology 2012; 6: 309-313. (VUmc)

300. De Bonilla-Damia A, Brouwer OR, Meinhardt W, Valdes-Olmos RA. Lymphatic Drainage in Prostate Carcinoma assessed by Lymphoscintigraphy and SPECT/CT: Its importance for the Sentinel Node Procedure. Rev Esp Med Nucl Imagen Mol 2012; 31: 66-70 (NKI)

301. de Bree R, Haigentz M, Silver CE, Paccagnella D, Hamoir M, Hartl DM, Machiels JP, Paleri V, Rinaldo A, Shaha AR, Takes RP, Leemans CR, Ferlito A. Distant metastases from head and neck squamous cell carcinoma. Part II. Diagnosis. Oral Oncology 2012; 48: 780-786. (VUmc)

302. de Bruijn MJ, ten Bosch L, Kuik DJ, Witte BI, Langendijk JA, Leemans CR, Verdonck-de Leeuw IM. Acoustic-phonetic and artificial neural network feature analysis to assess speech quality of stop consonants produced by patients treated for oral or oropharyngeal cancer. Speech Communication 2012; 54: 632-640. (VUmc)

303. de Bruin RC, Schneiders FL, Santegoets SJ, Verheul HM, de Gruijl TD, van der Vliet HJ. Bulldozing Beta-linked glycolipids for recognition by invariant NKT cells. Immunotherapy 2012; 4: 20. (VUmc)

304. de Bruin RCG, Schneiders FL, Santegoets SJAM, Verheul HMW, de Gruijl TD, van der Vliet HJ. Gram-positive bacteria: a major microbial 'turn-on' for invariant NKT cells. Immunotherapy 2012; 4: 19. (VUmc)

305. de Bruin RCG, Schneiders FL, Santegoets SJAM, Verheul HMW, De Gruijl TD, Van der Vliet HJ. An alpha-galactosylceramide nose job shapes up iNKT cells. Immunotherapy 2012; 4: 20-21. (VUmc)

306. De Bruin-Visser JC, Ackerstaff AH, Rehorst H, Hilgers FJM. Integration of a smoking cessation program in the treatment protocol for patients with head and neck and lung cancer. Eur Arch ORL 2012; 269: 659–65 (NKI)

307. de Crom SCM, Obihara CC, van Loon AM, rgilagos-Alvarez AA, Peeters MF, van Furth AM, Rossen JWA. Detection of enterovirus RNA in cerebrospinal fluid: Comparison of two molecular assays. Journal of Virological Methods 2012; 179: 104-107. (VUmc)

308. de Crom SCM, van Furth MAM, Peeters MF, Rossen JWA, Obihara CC. Characteristics of pediatric patients with enterovirus meningitis and no cerebral fluid pleocytosis. European Journal of Pediatrics 2012; 171: 795-800. (VUmc)

309. de Cuba EMV, Kwakman R, van Egmond M, Bosch LJW, Bonjer HJ, Meijer GA, te Velde EA. Understanding molecular mechanisms in peritoneal dissemination of colorectal cancer. Virchows Archiv 2012; 461: 231-243. (VUmc)

310. de Goede B, Klitsie PJ, Lange JF, Metselaar HJ, Kazemier G. Morbidity and mortality related to non-hepatic surgery in patients with liver cirrhosis; A systematic review. Best Pract Res Clin Gastroenterol 2012; 26: 47-59. (VUmc)

311. de Graaf P, Goricke S, Rodjan F, Galluzzi P, Maeder P, Castelijns JA, Brisse HJ. Guidelines for imaging retinoblastoma: imaging principles and MRI standardization. Pediatric Radiology 2012; 42: 2-14. (VUmc)


312. de Graaf P, Pouwels PJW, Rodjan F, Moll AC, Imhof SM, Knol DL, Sanchez E, van der Valk P, Castelijns JA. Single-Shot Turbo Spin-Echo Diffusion-Weighted Imaging for Retinoblastoma: Initial Experience. American Journal of Neuroradiology 2012; 33: 110-118. (VUmc)

313. de Graaf W, Heger M, Spruijt O, Maas A, de Bruin K, Hoekstra R, Bennink RJ, van Gulik TM. Quantitative Assessment of Liver Function after Ischemia-Reperfusion Injury and Partial Hepatectomy in Rats. Journal Of Surgical Research 2012; 172(1): 85-94. (AMC)

314. de Groot M, Iyer A, Zurolo E, Anink J, Heimans JJ, Boison D, Reijneveld JC, Aronica E. Overexpression of ADK in human astrocytic tumors and peritumoral tissue is related to tumor-associated epilepsy. Epilepsia 2012; 53: 58-66. (VUmc)

315. de Groot M, Reijneveld JC, Aronica E, Heimans JJ. Epilepsy in patients with a brain tumour: focal epilepsy requires focused treatment. Brain 2012; 135: 1002-1016. (VUmc)

316. de Groot MH, van der Jagt-Willems H, van Campen JPCM, Lems WF, Lamoth CJC. Testing postural control among various osteoporotic patient groups: A literature review. Geriatrics & Gerontology International 2012; 12: 573-585. (VUmc)

317. de Gruijl TD. Dendritic Cell Subsets In Human Skin and Their Role In T-Cell Activation. Experimental Dermatology 2012; 21: 802-804. (VUmc)

318. de Haan MC, Nio CY, Thomeer M, de Vries AH, Bossuyt PM, Kuipers EJ, Dekker E, Stoker J. Comparing the diagnostic yields of technologists and radiologists in an invitational colorectal cancer screening program performed with CT colonography. Radiology 2012; 264(3): 771-778. (AMC)

319. de Haan TR, Bijleveld YA, van der Lee JH, Groenendaal F, van den Broek MPH, Rademaker CMA, van Straaten HLM, van Weissenbruch MM, Vermeulen JR, Dijk PH, Dudink J, Rijken M, van Heijst A, Dijkman KP, Gavilanes D, van Kaam AH, Offringa M, Mathôt RAA. Pharmacokinetics and pharmacodynamics of medication in asphyxiated newborns during controlled hypothermia. The PharmaCool multicenter study. BMC Pediatrics 2012; 12(1): 45-. (AMC)

320. De Haas EC, Altena R, Boezen HM, Zwart N, Smit AJ, Bakker SJ, van Roon AM, Postma A, Wolffenbuttel BH, Hoekstra HJ, van Leeuwen FE, Sleijfer DT, Gietema JA. Early development of the metabolic syndrome after chemotherapy for testicular cancer. Ann Oncol 2012 (NKI)

321. de Jong A, Merkx R, Berlin I, Rodenko B, Wijdeven RH, El Atmioui D, Yalçin Z, Robson CN, Neefjes JJ, Ovaa H. Ubiquitin-based probes prepared by total synthesis to profile the activity of deubiquitinating enzymes. Chembiochem 2012; 13: 2251-8 (NKI)

322. De Jong A, Schuurman KG,, e al. Fluorescence-based proteasome activityprofiling. Methods Mol Biol 2012: 803: 183-204 (NKI)

323. de Jong JH, Rodermond HM, Zimberlin CD, Lascano V, de Sousa e Melo F, Richel DJ, Medema JP, Vermeulen L. Fusion of intestinal epithelial cells with bone marrow derived cells is dispensable for tissue homeostasis. Scientific Reports 2012; 2: 271-. (AMC)

324. de Jong K, Bruno MJ, Fockens P. Epidemiology, Diagnosis, and Management of Cystic Lesions of the Pancreas. Gastroenterology Research And Practice 2012; 1155-2012: 147465-.

325. de Jong K, Nio CY, Mearadji B, Phoa SS, Engelbrecht MR, Dijkgraaf MG, Bruno MJ, Fockens P. Disappointing interobserver agreement among radiologists for a classifying diagnosis of pancreatic cysts using magnetic resonance imaging. Pancreas 2012; 41(2): 278-282. (AMC)

326. de Jong K, Poley JW, van Hooft JE, Visser M, Bruno MJ, Fockens P. Reply to ustundag et Al. Endoscopy 2012; 44(1): 105-. (AMC)

327. de Jong K, van Hooft JE, Nio CY, Gouma DJ, Dijkgraaf MGW, Bruno MJ, Fockens P. Accuracy of preoperative workup in a prospective series of surgically resected cystic pancreatic lesions. Scandinavian Journal Of Gastroenterology 2012; 47(8-9): 1056-1063. (AMC)

328. de Jong MAA, Oldenborg S, Bing Oei S, Griesdoorn V, Kolff MW, Koning CCE, van Tienhoven G. Reirradiation and hyperthermia for radiation-associated sarcoma. Cancer 2012; 118(1): 180-187. (AMC)

329. De Jonge V, Sint Nicolaas J, Cahen DL, Moolenaar W, Ouwendijk RJ, Tang TJ, van Tilburg AJ, Kuipers EJ, van Leerdam ME; SCoPE Consortium. Quality evaluation of colonoscopy reporting and colonoscopy performance in daily clinical practice. Gastrointest Endosc 2012; 75: 98-106 (NKI)

330. De Jonge V, Sint Nicolaas J, van Baalen O, Brouwer JT, Stolk MF, Tang TJ, van Tilburg AJ, van Leerdam ME, Kuipers EJ; SCoPE consortium. The incidence of 30-day adverse events after colonoscopy among outpatients in the Netherlands. Am J Gastroenterol 2012; 107: 878-84 (NKI)

331. de Kant-Pariama E, Preckel B, Schlack WS, Nieveen van Dijkum EJM. Cuff perforation by dislocated electrodes of an clectromyogram tube. Anesthesia And Analgesia 2012; 115(6): 1473-. (AMC)

332. de Kinkelder R, van Leeuwen TG, Verbraak FD. Detection of early-stage age related macular degeneration with a compact rarebit test. British Journal Of Ophthalmology 2012; 96(10): 1354-1355. (AMC)

333. de Kivit S, Saeland E, Kraneveld AD, van de Kant HJG, Schouten B, van Esch BCAM, Knol J, Sprikkelman AB, van der Aa LB, Knippels LMJ, Garssen J, van Kooyk Y, Willemsen LEM. Galectin-9 induced by dietary synbiotics is involved in suppression of allergic symptoms in mice and humans. Allergy 2012; 67: 343-352. (VUmc)

334. de Korte N, Kuyvenhoven JP, van der Peet DL, Felt-Bersma RJ, Cuesta MA, Stockmann HBAC. Mild colonic diverticulitis can be treated without antibiotics. a case-control study. Colorectal Disease 2012; 14: 325-330. (VUmc)

335. de Kruif Martijn D, van Gorp ECM, Bel EH, Gerlag DM, Kunst PW. Streptococcal lung abscesses from a dental focus following tocilizumab: a case report. Clinical And Experimental Rheumatology 2012; 30(6): 951-953. (AMC)

336. de la Rosette J. The Time Is Now-the Ability Is Yours. European Urology 2012; 61(6): 1194-1195. (AMC) 337. de La Rosette JJMCH, Opondo D, Daels FPJ, Giusti G, Serrano A, Kandasami SV, Wolf Jr. JS, Grabe M, Gravas S.

Categorisation of complications and validation of the Clavien score for percutaneous nephrolithotomy. European Urology 2012; 62(2): 246-255. (AMC)

338. de La Rosette JJMCH, Opondo D. Reply from Authors re: Jens J. Rassweiler, Marie-Claire Rassweiler, Maurice-Stephan Michel. Classification of Complications: Is the Clavien-Dindo Classification the Gold Standard? Eur Urol. In press. http://dx.doi.org/10.1016/j.eururo.2012.04.028: The Boundary of Surgical Errors and Complications. European Urology 2012; 62(2): 259-260. (AMC)

339. De Langen AJ, Vincent A, Velasquez LM, van Tinteren H, Boellaard R, Shankar LK, Boers M, Smit EF, Stroobants S, Weber WA, Hoekstra OS. Repeatability of 18F-FDG uptake measurements in tumors: a metaanalysis. J Nucl Med 2012; 53: 701-708 (NKI/VUmc)


340. De Lau W, Kujala P, Schneeberger K, Middendorp S, Li VS, Barker N, Martens A, Hofhuis F, DeKoter RP, Peters PJ, Nieuwenhuis E, Clevers H. Peyer's patch M cells derived from Lgr5(+) stem cells require SpiB and are induced by RankL in cultured "miniguts". Mol Cell Biol 2012; 32: 3639-47 (NKI)

341. de Leeuw R, Flach K, Bentin Toaldo C, Alexi X, Canisius S, Neefjes J, Michalides R, Zwart W. PKA phosphorylation redirects ERα to promoters of a unique gene set to induce tamoxifen resistance. Oncogene 2012; 1-9 (NKI)

342. de Lijster MS, Bergevoet RM, van Dalen EC, Michiels EMC, Caron HN, Kremer LCM, Aronson DC. Minimally invasive surgery versus open surgery for the treatment of solid abdominal and thoracic neoplasms in children. Cochrane Database Of Systematic Reviews 2012; 2012(1): CD008403-. (AMC)

343. De Melker H, Kenter G, van Rossum T, Conyn-van Spaendonck M. Developments in HPV vaccination. Ned Tijdschr Geneeskd 2012; 156: A5410 (NKI)

344. de Miranda NFCC, Goudkade D, Jordanova ES, Tops CMJ, Hes FJ, Vasen HFA, van Wezel T, Morreau H. Infiltration of Lynch Colorectal Cancers by Activated Immune Cells Associates with Early Staging of the Primary Tumor and Absence of Lymph Node Metastases. Clin Cancer Res 2012; 18: 1237-1245. (VUmc)

345. De Ridder M, Smeele LE, Balm AJM. Klinische les: Het pleiomorf adenoom van de glandula parotis; regels voor resectie. Ned Tijdschr Geneeskd 2012; 156: 773-8 (NKI)

346. De Ronde JJ, Lips EH, Mulder L, Vincent AD, Wesseling J, Nieuwland M, Kerkhoven R, Vrancken Peeters MJ, Sonke GS, Rodenhuis S, Wessels LFA. SERPINA6, BEX1, AGTR1, SLC26A3, and LAPTM4B are markers of resistance to neoadjuvant chemotherapy in HER2- negative breast cancer. Breast Cancer Res Treat. 2013; 137: 213-23 (NKI)

347. de Rooij MFM, Kuil A, Geest CR, Eldering E, Chang BY, Buggy JJ, Pals ST, Spaargaren M. The clinically active BTK inhibitor PCI-32765 targets B-cell receptor- and chemokine-controlled adhesion and migration in chronic lymphocytic leukemia. Blood 2012; 119(11): 2590-2594. (AMC)

348. de Rooij SE, Royen H, Hamaker M, Blom H, Portielje J, Bartelsman JF. IJzergebreksanemie bij 80-plussers. Nederlands Tijdschrift Voor Geneeskunde 2012; 156(43): A5236-. (AMC)

349. de Rotte MCFJ, Bulatovic M, Heijstek MW, Jansen G, Heil SG, van Schaik RHN, Wulffraat NM, de Jonge R. ABCB1 and ABCC3 Gene Polymorphisms Are Associated with First-year Response to Methotrexate in Juvenile Idiopathic Arthritis. Journal of Rheumatology 2012; 39: 2032-2040. (VUmc)

350. de Ruiter MA, Schouten-van Meeteren AYN, van Mourik R, Janssen TWP, Greidanus JEM, Oosterlaan J, Grootenhuis MA. Neurofeedback to improve neurocognitive functioning of children treated for a brain tumor: design of a randomized controlled double-blind trial. BMC Cancer 2012; 12(1): 581-. (AMC)

351. de Ruiter MB, Reneman L, Boogerd W, Veltman DJ, Caan M, Douaud G, Lavini C, Linn SC, Boven E, van Dam FSAM, Schagen SB. Late effects of high-dose adjuvant chemotherapy on white and gray matter in breast cancer survivors: converging results from multimodal magnetic resonance imaging. Human Brain Mapping 2012; 33(12): 2971-2983. (AMC/NKI/VUmc)

352. De Smet AMGA, Bonten MJM, Kluytmans JAJW. For whom should we use selective decontamination of the digestive tract?. Current Opinion in Infectious Diseases 2012; 25: 211-217. (VUmc)

353. De Smet AMGA, Kluytmans JAJW, Bonten MJM. Resistance after selective decontamination reply. Lancet Infectious Diseases 2012; 12: 180-181. (VUmc)

354. de Sousa e Melo F, Medema JP. Axing Wnt signals. Cell Research 2012; 22(1): 9-11. (AMC) 355. De Visser KE*, Ciampricotti M, Michalak E, Wei-Min Tan D, Speksnijder EN, Hau CS, Clevers H, Barker N, Jonkers J*.

Developmental stagespecific contribution of LGR5+ cells to basal and luminal epithelial lineages in the postnatal mammary gland. J Pathol 2012; 228: 300-9 (* joint corresponding authors) (NKI)

356. de Vos FYFL, van Laarhoven HMW. Taxus baccata allergy in a breast cancer patient. Netherlands Journal Of Medicine 2012; 70(5): 249-. (AMC)

357. de Vos FYFL, van Laarhoven HWM., Laven JSE, Themmen APN, Beex LVAM, Sweep CGJ, Seynaeve C, Jager A. Menopausal status and adjuvant hormonal therapy for breast cancer patients: a practical guideline. Critical Reviews In Oncology Hematology 2012; 84(2): 252-260. (AMC)

358. de Vos J, Gomez-Garcia E, Oosterwijk JC, Menko FH, Stoel RD, van Asperen CJ, Jansen AM, Stiggelbout AM, Tibben A. Opening the psychological black box in genetic counseling. The psychological impact of DNA testing is predicted by the counselees' perception, the medical impact by the pathogenic or uninformative BRCA1/2-result. Psycho-Oncology 2012; 21: 29-42. (VUmc)

359. de Vos J, Oosterwijk JC, Gomez-Garcia E, Menko FH, Collee MJ, van Asperen CJ, Jansen AM, Stiggelbout AM, Tibben A. Exploring the short-term impact of DNA-testing in breast cancer patients: The counselees' perception matters, but the actual BRCA1/2 result does not. Patient Education and Counseling 2012; 86: 239-251. (VUmc)

360. De Vos van Steenwijk PJ, Ramwadhdoebe TH, Löwik MJ, van der Minne CE, Berends-van der Meer DM, Fathers LM, Valentijn AR, Oostendorp J, Fleuren GJ, Hellebrekers BW, Welters MJ, van Poelgeest MI, Melief CJ, Kenter GG, van der Burg SH. A placebo-controlled randomized HPV16 synthetic long-peptide vaccination study in women with high-grade cervical squamous intraepithelial lesions. Cancer Immunol Immunother 2012; 61: 1485-92 (NKI)

361. de Vries EN, Prins HA, Bennink MC, Neijenhuis P, van Stijn I, van Helden SH, van Putten MA, Smorenburg SM, Gouma DJ, Boermeester MA. Nature and timing of incidents intercepted by the SURPASS checklist in surgical patients. BMJ Quality & Safety 2012; 21(6): 503-508. (AMC)

362. de Vries M, Oude Munnink BB, Deijs M, Canuti M, Koekkoek SM, Molenkamp R, Bakker M, Jurriaans S, van Schaik BDC, Luyf AC, Olabarriaga SD, van Kampen AHC, van der Hoek L. Performance of VIDISCA-454 in feces-suspensions and serum. Viruses-Basel 2012; 4(8): 1328-1334. (AMC)

363. De Vries NA, Buckle T, Zhao J, Beijnen JH, Schellens JH, van Tellingen O. Restricted brain penetration of the tyrosine kinase inhibitor erlotinib due to the drug transporters P-gp and BCRP. Invest New Drugs 2012; 30: 443-9 (NKI)

364. De Vries RR, Kauer P, van Tinteren H, van der Poel HG, Bex A, Meinhardt W, et al. Short-term outcome after cystectomy: comparison of two different perioperative protocols. Urol Int 2012; 88: 383-9 (NKI)

365. De Vries RR. The surgical management of invasive bladder cancer [urol NKI]. Amsterdam: Free University; 2012 (NKI) 366. de Vries Y, Lwiwski N, Levitus M, Kuyt B, Israels SJ, Arwert F, Zwaan M, Greenberg CR, Alter BP, Joenje H,

Meijers-Heijboer H. A Dutch Fanconi Anemia FANCC Founder Mutation in Canadian Manitoba Mennonites. Anemia 2012; 2012: 865170-. (AMC/VUmc)

367. De Vuyst H, Mugo NR, Chung MH, McKenzie KP, Nyongesa-Malava E, Tenet V, Njoroge JW, Sakr SR, Meijer CJLM, Snijders PJF, Rana FS, Franceschi S. Prevalence and determinants of human papillomavirus infection and cervical lesions in HIV-positive women in Kenya. Br J Cancer 2012; 107: 1624-1630. (VUmc)


368. De Vuyst H, Ndirangu G, Moodley M, Tenet V, Estambale B, Meijer CJLM, Snijders PJF, Clifford G, Franceschi S. Prevalence of human papillomavirus in women with invasive cervical carcinoma by HIV status in Kenya and South Africa. International Journal of Cancer 2012; 131: 949-955. (VUmc)

369. De Weger VA, Turksma AW, Voorham QJ, Euler Z, Bril H, van den Eertwegh AJ, Bloemena E,Pinedo HM, Vermorken JB, van Tinteren H, Meijer GA, Hooijberg E. Clinical effects of adjuvant active specific immunotherapy differ between patients with microsatellitestable and microsatellite-instable colon cancer. Clin Cancer Res 2012; 18: 882- 889 (NKI/VUmc)

370. de Wijkerslooth TR, de Haan MC, Stoop EM, Bossuyt PM, Thomeer M, Essink-Bot M, van Leerdam ME, Fockens P, Kuipers EJ, Stoker J, Dekker E. Burden of colonoscopy compared to non-cathartic CT-colonography in a colorectal cancer screening programme: randomised controlled trial. GUT 2012; 61(11): 1552-1559. (AMC/NKI)

371. de Wijkerslooth TR, de Haan MC, Stoop EM, Bossuyt PM, Thomeer M, van Leerdam ME, Essink-Bot M, Fockens P, Kuipers EJ, Stoker J, Dekker E. Reasons for participation and nonparticipation in colorectal cancer screening: a randomized trial of colonoscopy and CT colonography. American Journal Of Gastroenterology 2012; 107(12): 1777-1783. (AMC)

372. De Wijkerslooth TR, Stoop EM, Bossuyt PM, Mathus-Vliegen EM, Dees J, Tytgat KM, van Leerdam ME, Fockens P, Kuipers EJ, Dekker E. Adenoma detection with capassisted colonoscopy versus regular colonoscopy: a randomised controlled trial. Gut 2012; 61: 1426-34 (NKI/AMC)

373. de Wijkerslooth TR, Stoop EM, Bossuyt PM, Meijer GA, van Ballegooijen M, van Roon AHC, Stegeman I, Kraaijenhagen RA, Fockens P, van Leerdam ME, Dekker E, Kuipers EJ. Immunochemical fecal occult blood testing is equally sensitive for proximal and distal advanced neoplasia. American Journal Of Gastroenterology 2012; 107(10): 1570-1578. (AMC/NKI/VUmc)

374. de Wijkerslooth TR, Stoop EM, Bossuyt PM, van Leerdam ME, Fockens P, Kuipers EJ, Dekker E. Evaluating cap-assisted colonoscopy: the relevance of study design : Authors' response. GUT 2012; 61(10): 1517-1518. (AMC)

375. de Wilde RF, Besselink MGH, Borel Rinkes IHM, de Hingh IHJT, van Eijck CHJ, Dejong CHC, Porte RJ, Gouma DJ, Busch ORC, Molenaar IQ. Centralisatie pancreaschirurgie reduceert postoperatieve sterfte in Nederland*. Nederlands Tijdschrift Voor Geneeskunde 2012; 156(32): A4791-. (AMC)

376. de Wilde RF, Besselink MGH, van der Tweel I, de Hingh IHJT, van Eijck CHJ, Dejong CHC, Porte RJ, Gouma DJ, Busch ORC, Molenaar IQ. Impact of nationwide centralization of pancreaticoduodenectomy on hospital mortality. British Journal Of Surgery 2012; 99(3): 404-410. (AMC)

377. De Wilt LHAM, Jansen G, Assaraf YG, van Meerloo J, Cloos J, Schimmer AD, Chan ET, Kirk CJ, Peters GJ, Kruyt FAE. Proteasome-based mechanisms of intrinsic and acquired bortezomib resistance in non-small cell lung cancer. Biochemical Pharmacology 2012; 83: 207-217. (VUmc)

378. de Wit M, Jimenez CR, Carvalho B, Belien JAM, is-van Diemen PM, Mongera S, Piersma SR, Vikas M, Navani S, Ponten F, Meijer GA, Fijneman RJA. Cell surface proteomics identifies glucose transporter type 1 and prion protein as candidate biomarkers for colorectal adenoma-to-carcinoma progression. Gut 2012; 61: 855-864. (VUmc)

379. Deenen MJ, Cats A, Mandigers CM, Soesan M, Terpstra WE, Beijnen JH, Schellens JH. Het nut van testen op dihydropyrimidine dehydrogenase (DPD) deficientie in de behandeling met capecitabine, 5-fluorouracil en UFT. [Prevention of severe toxicity from capecitabine, 5-fluorouracil and tegafur by screening for DPD-deficiency] Ned Tijdschr Geneeskd 2012; 156: A4934 (NKI)

380. Deenen MJ, Klümpen H, Richel DJ, Sparidans RW, Weterman MJ, Beijnen JH, Schellens JHM, Wilmink JW. Phase I and pharmacokinetic study of capecitabine and the oral mTOR inhibitor everolimus in patients with advanced solid malignancies. Investigational New Drugs 2012; 30(4): 1557-1565. (AMC/NKI)

381. Defraene G, Van den Bergh L, Al-Mamgani A, Haustermans K, Heemsbergen W, Van den Heuvel F, Lebesque JV. The benefits of including clinical factors in rectal normal tissue complication probability modeling after radiotherapy for prostate cancer. Int J Radiat Oncol Biol Phys 2012; 82: 1233-42 (NKI)

382. Deganello A, Gitti G, Parrinello G, Larotonda G, Meccariello G, Leemans CR, Gallo O. Infrahyoid flap reconstruction of oral cavity and oropharyngeal defects in elderly patients with severe general comorbidities. Head and Neck-Journal for the Sciences and Specialties of the Head and Neck 2012; 34: 1299-1305. (VUmc)

383. Dekker CMG, Van Esch L, De Vries J, Ernst MF, Nieuwenhuijzen GAP, Roukema JA, van der Steeg AFW. An abnormal screening mammogram causes more anxiety than a palpable lump in benign breast disease. Breast Cancer Research and Treatment 2012; 134: 253-258. (VUmc)

384. Dekker CMG, Van Esch L, Schreurs WH, van Berlo CLH, Roukema JA, De Vries J, van der Steeg AFW. Health care utilization one year following the diagnosis benign breast disease or breast cancer. Breast 2012; 21: 746-750. (VUmc)

385. Dekker E. Gastrointestinal cancer: Should colonoscopy be a primary test in CRC screening? Nature Reviews Clinical Oncology 2012; 9(5): 252-254. (AMC)

386. Dekker J. Osteoarthritis Promoting exercise for OA in ambivalent older adults. Nature Reviews Rheumatology 2012; 8: 442-444. (VUmc)

387. Dekker TJ, Borg ST, Hooijer GK, Meijer SL, Wesseling J, Boers JE, Schuuring E, Bart J, van Gorp J, Mesker WE, Kroep JR, Smit VT, van de Vijver MJ. Determining sensitivity and specificity of HER2 testing in breast cancer using a tissue micro-array approach. Breast Cancer Res 2012; 14: R93 (NKI/AMC)

388. del Pilar Laguna M, Zondervan PJ, de La Rosette JJMCH. Focal therapy in the management of small renal masses. Current Opinion In Urology 2012; 22(5): 372-378. (AMC)

389. Del Pino M, Bleeker MCG, Quint WG, Snijders PJF, Meijer CJLM, Steenbergen RDM. Comprehensive analysis of human papillomavirus prevalence and the potential role of low-risk types in verrucous carcinoma. Modern Pathology 2012; 25: 1354-1363. (VUmc)

390. Den Brok MH, Nierkens S, Wagenaars JA, Ruers TJ, Schrier CC, Rijke EO, Adema GJ. Saponin-based adjuvants create a highly effective anti-tumor vaccine when combined with in situ tumor destruction. Vaccine 2012; 30: 737-44 (NKI)

391. den Burger JCG, Wilhelm AJ, Chahbouni A, Vos RM, Sinjewel A, Swart EL. Analysis of cyclosporin A, tacrolimus, sirolimus, and everolimus in dried blood spot samples using liquid chromatography tandem mass spectrometry. Analytical and Bioanalytical Chemistry 2012; 404: 1803-1811. (VUmc)

392. den Haan JM, Mebius RE, Kraal G. Stromal cells of the mouse spleen. Frontiers in Immunology 2012; 3: 201. (VUmc) 393. den Haan JMM, Kraal G. Innate Immune Functions of Macrophage Subpopulations in the Spleen. Journal of Innate

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394. den Hertog J, van Leengoed E, Kolk F, van den Broek L, Kramer E, Bakker EJ, Bakker-van Gijssel E, Bulk A, Kneepkens F, Benninga MA. The defecation pattern of healthy term infants up to the age of 3 months. Archives of Disease in Childhood-Fetal and Neonatal Edition 2012; 97: F465-F470. (VUmc)

395. den Uyl D, van Raalte DH, Nurmohamed MT, Lems WF, Bijlsma JWJ, Hoes JN, Dijkmans BAC, Diamant M. Metabolic effects of high-dose prednisolone treatment in early rheumatoid arthritis: Balance between diabetogenic effects and inflammation reduction. Arthritis and Rheumatism 2012; 64: 639-646. (VUmc)

396. Deng X, Li Q, Hoff J, Novak M, Yang H, Jin H, Erfani SF, Sharma C, Zhou P, Rabinovitz I, Sonnenberg A, Yi Y, Zhou P, Stipp CS, Kaetzel DM, Hemler ME, Yang XH. Integrin-associated CD151 drives ErbB2-evoked mammary tumor onset and metastasis. Neoplasia 2012; 14: 678-89 (NKI)

397. Denters Maaike J., Deutekom Marije, Bossuyt Patrick M., Stroobants An K., Fockens Paul, Dekker Evelien: Lower risk of advanced neoplasia among patients with a previous negative result from a fecal test for colorectal cancer. Gastroenterology 2012; 142(3): 497-504. (AMC)

398. Dentler K, Cornet R, ten Teije A, Tytgat K, Klinkenbujl J, de Keizer N. The reproducibility of CLIF, a method for clinical quality indicator formalisation. Studies In Health Technology And Informatics 2012; 180: 113-117. (AMC)

399. DeSouza N, Hoekstra OS, Nestle U, Stroobants S, Boellaard R, Schaefer-Prokop C, Shankar LK, Pylkkanen L, Hristova I, Bean JF. EORTC Imaging Group. European Journal of Cancer 2012; 10: 82-87. (VUmc)

400. Deurloo EE, Sriram JD, Teertstra HJ, Loo CE, Wesseling J, Rutgers EJT, Gilhuijs KGA. MRI of the breast in patients with DCIS to exclude the presence of invasive disease. European Radiology 2012; 22(7): 1504-1511. (AMC/NKI)

401. Devriese LA, Bosma AJ, Van de Heuvel MM, Heemsbergen W, Voest EE, Schellens JH. Circulating tumor cell detection in advanced non-small cell lung cancer patients by multimarker QPCR analysis. Lung Cancer 2012; 75: 242-7 (NKI)

402. Devriese LA, Witteveen PO, Marchetti S, Mergui-Roelvink M, Reyderman L, Wanders J, Jenner A, Edwards G, Beijnen JH, Voest EE, Schellens JH. Pharmacokinetics of eribulin mesylate in patients with solid tumors and hepatic impairment. Cancer Chemother Pharmacol 2012; 70: 823-32 (NKI)

403. Dhaliwal K, Scholefield E, Ferenbach D, Gibbons M, Duffin R, Dorward DA, Morris AC, Humphries D, MacKinnon A, Wilkinson TS, Wallace WAH, Van Rooijen N, Mack M, Rossi AG, Davidson DJ, Hirani N, Hughes J, Haslett C, Simpson AJ. Monocytes Control Second-Phase Neutrophil Emigration in Established Lipopolysaccharide-induced Murine Lung Injury. Am J Respir Crit Care Med 2012; 186: 514-524. (VUmc)

404. Dicker GJ, Koolstra JH, Castelijns JA, Van Schijndel RA, Tuinzing DB. Positional changes of the masseter and medial pterygoid muscles after surgical mandibular advancement procedures: an MRI study. International Journal of Oral and Maxillofacial Surgery 2012; 41: 922-929. (VUmc)

405. Dicker GJ, Tuijt M, Koolstra JH, Van Schijndel RA, Castelijns JA, Tuinzing DB. Static and dynamic loading of mandibular condyles and their positional changes after bilateral sagittal split advancement osteotomies. International Journal of Oral and Maxillofacial Surgery 2012; 41: 1131-1136. (VUmc)

406. Dijkema T, Terhaard CHJ, Roesink JM, Raaijmakers CPJ, van den Keijbus PAM, Brand HS, Veerman ECI. MUC5B levels in submandibular gland saliva of patients treated with radiotherapy for head-and-neck cancer: A pilot study. Radiation Oncology 2012; 7: . (VUmc)

407. Dijkmans AC, de Jong EP, Dijkmans BAC, Lopriore E, Vossen A, Walther FJ, Oepkes D. Parvovirus B19 in pregnancy: prenatal diagnosis and management of fetal complications. Current Opinion in Obstetrics & Gynecology 2012; 24: 95-101. (VUmc)

408. Dijksman LM, Roos D, Gerhards MF, Tijssen JGP, Gouma DJ, Dijkgraaf MGW. Cost-Effectiveness of Perioperative Selective Decontamination of the Digestive Tract versus Placebo in Elective Gastrointestinal Surgery. Digestive Surgery 2012; 29(5): 384-390. (AMC)

409. Dijkstra MG, Heideman DAM, van Kemenade FJ, Hogewoning KJA, Hesselink AT, Verkuijten MCGT, van Baal WM, Nieuwenhuyzen-de Boer GM, Snijders PJF, Meijer CJLM. Brush-based self-sampling in combination with GP5+/6+-PCR-based hrHPV testing: High concordance with physician-taken cervical scrapes for HPV genotyping and detection of high-grade CIN. Journal of Clinical Virology 2012; 54: 147-151. (VUmc)

410. Dikken JL, Coit DG, Klimstra DS, Rizk NP, van Grieken N, Ilson D, Tang LH. Prospective impact of tumor grade assessment in biopsies on tumor stage and prognostic grouping in gastroesophageal adenocarcinoma Relevance of the Seventh Edition American Joint Committee on Cancer Staging Manual Revision. Cancer 2012; 118: 349-357. (VUmc)

411. Dikken JL, Dassen AE, Lemmens VE, Putter H, Krijnen P, van der Geest L, Bosscha K, Verheij M, van de Velde CJ, Wouters MW. Effect of hospital volume on postoperative mortality and survival after oesophageal and gastric cancer surgery in the Netherlands between 1989 and 2009. Eur J Cancer 2012; 48: 1004-13 (NKI)

412. Dikken JL, Lemmens VE, Wouters MW, Wijnhoven BP, Siersema PD, Nieuwenhuijzen GA, van Sandick JW, Cats A, Verheij M, Coebergh JW, van de Velde CJ. Increased incidence and survival for oesophageal cancer but not for gastric cardia cancer in the Netherlands. Eur J Cancer 2012; 48: 1624-32 (NKI)

413. Dikken JL, Stiekema J, van de Velde CJ, Verheij M, Cats A, Wouters MW, van Sandick JW. Quality of care indicators for the surgical treatment of gastric cancer: a systematic review. Ann Surg Oncol. 2012 (NKI)

414. Dikken JL, van de Velde CJ, Coit DG, Shah MA, Verheij M, Cats A. Treatment of resectable gastric cancer. Therap Adv Gastroenterol 2012; 5: 49-69 (NKI)

415. Dikken JL, van de Velde CJ, Gönen M, Verheij M, Brennan MF, Coit DG. The New American Joint Committee on Cancer/International Union against cancer staging system for adenocarcinoma of the stomach: increased complexity without clear improvement in predictive accuracy. Ann Surg Oncol 2012; 19: 2443-51 (NKI)

416. Dikken JL, van Grieken NC, Krijnen P, Gönen M, Tang LH, Cats A, Verheij M, Brennan MF, van de Velde CJ, Coit DG. Preoperative chemotherapy does not influence the number of evaluable lymph nodes in resected gastric cancer. Eur J Surg Oncol 2012; 38: 319-25 (NKI/VUmc)

417. Dikken JL, Wouters MW, Lemmens VE, Putter H, van der Geest LG, Verheij M, Cats A, van Sandick JW, van de Velde CJ. Influence of hospital type on outcomes after oesophageal and gastric cancer surgery. Br J Surg 2012; 99: 954-63 (NKI)

418. Ding YC, McGuffog L, Healey S, Friedman E, Laitman Y, Paluch-Shimon S, Kaufman B, Liljegren A, Lindblom A, Olsson H, Kristoffersson U, Stenmark-Askmalm M, Melin B, Domchek SM, Nathanson KL, Rebbeck TR, Jakubowska A, Lubinski J, Jaworska K, Durda K, Gronwald J, Huzarski T, Cybulski C, Byrski T, Osorio A, Ramón y Cajal T, Stavropoulou AV, Benítez J, Hamann U, Rookus M, Aalfs CM, de Lange JL, Meijers-Heijboer HEJ, Oosterwijk JC, van Asperen CJ, Gómez García EB, Hoogerbrugge N, Jager A, van der Luijt RB, Easton DF, Peock S, Frost D, Ellis SD, Platte R, Fineberg E, Evans DG, Lalloo F, Izatt L, Eeles R, Adlard J, Davidson R, Eccles D, Cole T, Cook J, Brewer C, Tischkowitz M, Godwin AK, Pathak H, Stoppa-Lyonnet D, Sinilnikova OM, Mazoyer S, Barjhoux L, Léoné M, Gauthier-Villars M,


Caux-Moncoutier V, de Pauw A, Hardouin A, Berthet P, Dreyfus H, Fert Ferrer S, Collonge-Rame M, Sokolowska J, Buys S, Daly M, Miron A, Terry MB, Chung W, John EM, Southey M, Goldgar D, Singer CF, Muy-Kheng MT, Gschwantler-Kaulich D, Fink-Retter A, Hansen TVO, Ejlertsen B, Johannsson OT, Offit K, Sarrel K, Gaudet MM, Vijai J, Robson M, Piedmonte MR, Andrews L, Cohn D, DeMars LR, DiSilvestro P, Rodriguez G, Toland Ewart A, Montagna M, Agata S, Imyanitov E, Isaacs C, Janavicius R, Lazaro C, Blanco I, Ramus SJ, Sucheston L, Karlan BY, Gross J, Ganz PA, Beattie MS, Schmutzler RK, Wappenschmidt B, Meindl A, Arnold N, Niederacher D, Preisler-Adams S, Gadzicki D, Varon-Mateeva R, Deissler H, Gehrig A, Sutter C, Kast K, Nevanlinna H, Aittomäki K, Simard J, Spurdle AB, Beesley J, Chen X, Tomlinson GE, Weitzel J, Garber JE, Olopade OI, Rubinstein WS, Tung N, Blum JL, Narod SA, Brummel S, Gillen DL, Lindor N, Fredericksen Z, Pankratz VS, Couch FJ, Radice P, Peterlongo P, Greene MH, Loud JT, Mai PL, Andrulis IL, Glendon G, Ozcelik H, Gerdes A, Thomassen M, Jensen UB, Skytte A, Caligo M, Lee A, Chenevix-Trench G, Antoniou AC, Neuhausen SL. A nonsynonymous polymorphism in IRS1 modifies risk of developing breast and ovarian cancers in BRCA1 and ovarian cancer in BRCA2 mutation carriers. Cancer Epidemiology Biomarkers & Prevention 2012; 21(8): 1362-1370. (AMC/VUmc)

419. Dirven L, van den Broek M, Kroon HM, Grillet BAM, Han KH, Kerstens PJSM, Huizinga TWJ, Lems WF, Allaart CF. Large-joint damage in patients with early rheumatoid arthritis and its association with treatment strategy and damage of the small joints. Rheumatology 2012; 51: 2262-2268. (VUmc)

420. Dirven L, van den Broek M, van Groenendael JHLM, de Beus WM, Kerstens PJSM, Huizinga TWJ, Allaart CF, Lems WF. Prevalence of vertebral fractures in a disease activity steered cohort of patients with early active rheumatoid arthritis. BMC Musculoskeletal Disorders 2012; 13: . (VUmc)

421. Dirven L, Visser K, Klarenbeek NB, Ewals JAPM, Han KH, Peeters AJ, Kerstens PJSM, Huizinga TWJ, Dijkmans BAC, Allaart CF. Towards personalized treatment: predictors of short-term HAQ response in recent-onset active rheumatoid arthritis are different from predictors of rapid radiological progression. Scandinavian Journal of Rheumatology 2012; 41: 15-19. (VUmc)

422. Djajadiningrat R, Horenblas S. Competing-Risks Analysis in Patients with T1 Squamous Cell Carcinoma of The Penis. BJU Int. 2012 (NKI)

423. Dommering C, Marees T, Hout A, Imhof S, Meijers-Heijboer H, Ringens P, Leeuwen F, Moll A. RB1 mutations and second primary malignancies after hereditary retinoblastoma. Familial Cancer 2012; 11: 225-233 (NKI)

424. Dommering CJ, Garvelink MM, Moll AC, van Dijk J, Imhof SM, Meijers-Heijboer H, Henneman L. Reproductive behavior of individuals with increased risk of having a child with retinoblastoma. Clinical Genetics 2012; 81(3): 216-223. (AMC/ VUmc)

425. Dommering CJ, Marees T, van der Hout AH, Imhof SM, Meijers-Heijboer H, Ringens PJ, van Leeuwen FE, Moll AC. RB1 mutations and second primary malignancies after hereditary retinoblastoma. Familial Cancer 2012; 11(2): 225-233. (AMC/VUmc)

426. Dommering CJ, van der Hout AH, Meijers-Heijboer H, Marees T, Moll AC. IVF and retinoblastoma revisited. Fertility And Sterility 2012; 97(1): 79-81. (AMC/VUmc)

427. Donker JMW, van der Laan L, Hendriks YJAM, Kluytmans JAJW. Evaluation of Staphylococcus aureus Nasal Carriage Screening before Vascular Surgery. PloS one 2012; 7: . (VUmc)

428. Donker M, Hage JJ, Woerdeman LA, Rutgers EJT, Sonke GS, Vrancken Peeters MJTFD. Surgical complications of skin sparing mastectomy and immediate prosthetic reconstruction after neoadjuvant chemotherapy for invasive breast cancer. Eur J Surg Oncol 2012; 38: 25-30 (NKI)

429. Donker M, Straver ME, Rutgers EJ, Valdés Olmos RA, Loo CE, Sonke GS, Wesseling J, Vrancken Peeters MJ. Radioguided occult lesion localisation (ROLL) in breast-conserving surgery after neoadjuvant chemotherapy. Eur J Surg Oncol 2012; 38: 1218-24 (NKI)

430. Donker M, Straver ME, Rutgers EJ, Vrancken Peeters MJ. Radioguided occult lesion localisation (ROLL) in breast-conserving surgery after neoadjuvant chemotherapy. Eur J Surg Oncol 2012 (NKI)

431. Doornaert P, Dahele M, Senan S, Slotman B. Non-coplanar volumetric modulated arc therapy for irradiation of paranasal sinus tumors: In response to Al-Mamgani et al., Highly-conformal intensity-modulated radiotherapy reduced toxicity without jeopardizing outcome in patients with paranasal sinus cancer treated by surgery and radiotherapy or (chemo)radiation.. Oral Oncology 2012; 48: 905-911. (VUmc)

432. Doornebal CW, Klarenbeek S, Braumuller TM, Klijn CN, Ciampricotti M, Hau CS, Hollmann MW, Jonkers J*, de Visser KE*. A preclinical mouse model of invasive lobular breast cancer metastasis. Cancer Res. 2012 (* joint corresponding authors) (NKI)

433. Douma KF, Koning CC, de Haes HC, Zandbelt LC, Stalpers LJA, Smets EM. Do radiation oncologists tailor information to patients needs? And, if so, does it affect patients? Acta Oncologica 2012; 51(4): 512-520. (AMC)

434. Douma KFL, Koning CCE, Zandbelt LC, de Haes HCJM, Smets EMA. Do patients' information needs decrease over the course of radiotherapy? Supportive Care In Cancer 2012; 20(9): 2167-2176. (AMC)

435. Douma RA, Oduber CEU, Gerdes VEA, van Delden OM, van Eck-Smit BLF, Meijers JCM, van Beers EJ, Bouma Berto J, van der Horst CMAM, Bresser P. Chronic pulmonary embolism in Klippel-Trenaunay syndrome. Journal Of The American Academy Of Dermatology 2012; 66(1): 71-77. (AMC)

436. Drabek T, Janata A, Jackson EK, End B, Stezoski J, Vagni VA, Janesko-Feldman K, Wilson CD, Van Rooijen N, Tisherman SA, Kochanek PM. Microglial depletion using intrahippocampal injection of liposome-encapsulated clodronate in prolonged hypothermic cardiac arrest in rats. Resuscitation 2012; 83: 517-526. (VUmc)

437. Draht MXG, Riedl RR, Niessen H, Carvalho B, Meijer GA, Herman JG, van Engeland M, Melotte V, Smits KM. Promoter CpG island methylation markers in colorectal cancer: the road ahead. Epigenomics 2012; 4: 179-194. (VUmc)

438. Dressel AJ, van der Mijn JC, Aalders IJ, Rinkel RNPM, Van der Vliet HJ. Irinotecan-induced dysarthria. Case Reports in Oncology 2012; 5: 47-51. (VUmc)

439. Driessen NN, Boshoff HIM, Maaskant JJ, Gilissen SAC, Vink S, van der Sar AM, Vandenbroucke-Grauls CMJE, Bewley CA, Appelmelk BJ, Geurtsen J. Cyanovirin-N Inhibits Mannose-Dependent Mycobacterium-C-Type Lectin Interactions but Does Not Protect against Murine Tuberculosis. J Immunol 2012; 189: 3585-3592. (VUmc)

440. Dros J, Maarsingh OR, Beem L, van der Horst HE, ter Riet G, Schellevis FG, van Weert HCPM. Functional prognosis of dizziness in older adults in primary care: a prospective cohort study. Journal Of The American Geriatrics Society 2012; 60(12): 2263-2269. (AMC)

441. Dubbelman AC, Jansen RS, Rosing H, Darwish M, Hellriegel E, Robertson P Jr, Schellens JH, Beijnen JH. Metabolite profiling of bendamustine in urine of cancer patients after administration of [14C]bendamustine. Drug Metab Dispos 2012; 40: 1297-307 (NKI)


442. Dubbelman AC, Rosing H, Jansen RS, Mergui-Roelvink M, Huitema AD, Koetz B, Lymboura M, Reyderman L, Lopez-Anaya A, Schellens JH, Beijnen JH. Mass balance study of [¹4C]eribulin in patients with advanced solid tumors. Drug Metab Dispos 2012; 40: 313-21 (NKI)

443. Dubbelman AC, Rosing H, Thijssen B, Gebretensae A, Lucas L, Chen H, Shumaker R, Schellens JH, Beijnen JH. Development and validation of LC-MS/ MS assays for the quantification of E7080 and metabolites in various human biological matrices. J Chromatogr B Analyt Technol Biomed Life Sci 2012; 887-888: 25-34 (NKI)

444. Dubbelman AC, Tibben M, Rosing H, Gebretensae A, Nan L, Gorman SH, Robertson P Jr, Schellens JH, Beijnen JH. Development and validation of LCMS/ MS assays for the quantification of bendamustine and its metabolites in human plasma and urine. J Chromatogr B Analyt Technol Biomed Life Sci 2012; 893-894: 92-100 (NKI)

445. Dubbelman AC, Upthagrove A, Beijnen JH, Marchetti S, Tan E, Krone K, Anand S, Schellens JH. Disposition and metabolism of (14)C-dovitinib (TKI258), an inhibitor of FGFR and VEGFR, after oral administration in patients with advanced solid tumors. Cancer Chemother Pharmacol 2012; 70: 653-63 (NKI)

446. Duffy D, Perrin H, Abadie V, Benhabiles N, Boissonnas A, Liard C, Descours B, Reboulleau D, Bonduelle O, Verrier B, Van Rooijen N, Combadiere C, Combadiere B. Neutrophils Transport Antigen from the Dermis to the Bone Marrow, Initiating a Source of Memory CD8(+) T Cells. Immunity 2012; 37: 917-929. (VUmc)

447. Duijts SF, van Beurden M, Oldenburg HS, Hunter MS, Kieffer JM, Stuiver MM, Gerritsma MA, Menke-Pluymers MB, Plaisier PW, Rijna H, Lopes Cardozo AM, Timmers G, van der Meij S, van der Veen H, Bijker N, de Widt-Levert LM, Geenen MM, Heuff G, van Dulken EJ, Boven E, Aaronson NK. Efficacy of cognitive behavoiral therapy and physical exercise in alleviating treatment-induced menopausal symptoms in patients with breast cancer: results of a randomized, controlled, multicenter trial. J Clin Oncol, 2012; 30: 4124-33 (NKI/AMC/VUmc)

448. Duitman J, Hoogendijk AJ, Groot AP, Ruela de Sousa RR, van der Poll T, Florquin S, Spek C. A. CCAAT-enhancer binding protein delta (C/EBPδ) protects against Klebsiella pneumoniae-induced pulmonary infection: potential role for macrophage migration. Journal Of Infectious Diseases 2012; 206(12): 1826-1835. (AMC)

449. Duitman J, Schouten M, Groot AP, Daalhuisen JB, Florquin S, van der Poll T, Spek CA. CAAT/enhancer-binding protein δ facilitates bacterial dissemination during pneumococcal pneumonia in a platelet-activating factor receptor-dependent manner. Proceedings Of The National Academy Of Sciences Of The United States Of America 2012; 109(23): 9113-9118. (AMC)

450. Dukers-Muijrers NHTM, Morre SA, Speksnijder A, van der Sande MAB, Hoebe CJPA. Chlamydia trachomatis Test-of-Cure Cannot Be Based on a Single Highly Sensitive Laboratory Test Taken at Least 3 Weeks after Treatment. PloS one 2012; 7: . (VUmc)

451. Dulos J, Carven GJ, van Boxtel SJ, Evers S, Driessen-Engels LJA, Hobo W, Gorecka MA, de Haan AFJ, Mulders P, Punt CJA, Jacobs JFM, Schalken JA, Oosterwijk E, van Eenennaam H, Boots AM. PD-1 blockade augments Th1 and Th17 and suppresses Th2 responses in peripheral blood from patients with prostate and advanced melanoma cancer. Journal Of Immunotherapy 2012; 35(2): 169-178. (AMC)

452. Dummer R, Beyer M, Hymes K, Epping MT, Bernards R, Steinhoff M, Sterry W, Kerl H, Heath K, Ahern JD, Hardwick JS, Garcia-Vargas J, Baumann K, Rizvi S, Frankel SR, Whittaker SJ, Assaf C. Vorinostat combined with bexarotene for treatment of cutaneous T-cell lymphoma: in vitro and phase I clinical evidence supporting augmentation of retinoic acid receptor/retinoid X receptor activation by histone deacetylase inhibition. Leuk Lymphoma 2012; 53: 1501-8 (NKI)

453. Dumonceau J, Delhaye M, Tringali A, Dominguez-Munoz JE, Poley JW, Arvanitaki M, Costamagna G, Costea F, Devière J, Eisendrath P, Lakhtakia S, Reddy N, Fockens P, Ponchon T, Bruno M. Endoscopic treatment of chronic pancreatitis: European Society of Gastrointestinal Endoscopy (ESGE) Clinical Guideline. Endoscopy 2012; 44(8): 784-800. (AMC)

454. Dumonceau J, Koessler T, van Hooft JE, Fockens P. Endoscopic ultrasonography-guided fine needle aspiration: Relatively low sensitivity in the endosonographer population. World Journal Of Gastroenterology 2012; 18(19): 2357-2363. (AMC)

455. Durmus S, Sparidans RW, Wagenaar E, Beijnen JH, Schinkel AH. Oral availability and brain penetration of the B-RAFV600E inhibitor vemurafenib can be enhanced by the P-glycoprotein (ABCB1) and Breast Cancer Resistance Protein (ABCG2) inhibitor elacridar. Mol Pharm 2012; 9: 3236-45 (NKI)

456. Duyvené de Wit T, Borkhardt A, Chomienne C, Döhner H, Fibbe WE, Foà R, Hagenbeek A, Skoda RC, Smand CR, Jäger U. Raising hematology's European voice: the importance of calling yourself a hematologist. Haematologica-The Hematology Journal 2012; 97(4): 476-478. (AMC)

457. Dwivedi RC, St Rose S, Chisholm EJ, Georgalas C, Bisase B, Amen F, Kerawala CJ, Clarke PM, Nutting CM, Rhys-Evans PH, Harrington KJ, Kazi R. Evaluation of swallowing by Sydney Swallow Questionnaire (SSQ) in oral and oropharyngeal cancer patients treated with primary surgery. Dysphagia 2012; 27(4): 491-497. (AMC)

458. Eberl S, Preckel B, Fockens P, Hollmann MW. Analgesia without sedatives during colonoscopies: worth considering? Techniques In Coloproctology 2012; 16(4): 271-276. (AMC)

459. Edelbroek JR, Vermeer MH, Jansen PM, Stoof TJ, van der Linden MMD, Horvath B, van Baarlen J, Willemze R. Langerhans cell histiocytosis first presenting in the skin in adults: frequent association with a second haematological malignancy. British Journal of Dermatology 2012; 167: 1287-1294. (VUmc)

460. Edelman G, Manti V, van Ruth SM, van Leeuwen T, Aalders M. Identification and age estimation of blood stains on colored backgrounds by near infrared spectroscopy. Forensic Science International 2012; 220(1-3): 239-244. (AMC)

461. Edelman G, van Leeuwen TG, Aalders MCG. Hyperspectral imaging for the age estimation of blood stains at the crime scene. Forensic Science International 2012; 223(1-3): 72-77. (AMC)

462. Edelman GJ, Gaston E, van Leeuwen TG, Cullen PJ, Aalders MCG. Hyperspectral imaging for non-contact analysis of forensic traces. Forensic Science International 2012; 223(1-3): 28-39. (AMC)

463. Eechoute K, Van der Veldt AAM, Oosting S, Kappers MHW, Wessels JAM, Gelderblom H, Guchelaar HJ, Reyners AKL, van Herpen CML, Haanen JB, Mathijssen RHJ, Boven E. Polymorphisms in Endothelial Nitric Oxide Synthase (eNOS) and Vascular Endothelial Growth Factor (VEGF) Predict Sunitinib-Induced Hypertension. Clinical Pharmacology & Therapeutics 2012; 92: 503-510. (VUmc)

464. Eers DJ, Nachabé R, Hompes D, van Coevorden F, Lucassen GW, Hendriks BH, van Velthuysen ML, Wesseling J, Ruers TJ. Optical sensing for tumor detection in the liver. Eur J Surg Oncol 2013; 39: 68-75 (NKI)

465. Efficace F, Taphoorn M. Methodological issues in designing and reporting health-related quality of life in cancer clinical trials: the challenge of brain cancer studies. Journal of Neuro-Oncology 2012; 108: 221-226. (VUmc)

466. Eggermont AMM, Suciu S, Testori A, Kruit WH, Marsden J, Punt CJ, Santinami M, Salès F, Schadendorf D, Patel P, Dummer R, Robert C, Keilholz U, Yver A, Spatz A. Ulceration and stage are predictive of interferon efficacy in


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467. Eggermont AMM, Suciu S, Testori A, Santinami M, Kruit WHJ, Marsden J, Punt CJA, Salès F, Dummer R, Robert C, Schadendorf D, Patel PM, de Schaetzen G, Spatz A, Keilholz U. Long-Term Results of the Randomized Phase III Trial EORTC 18991 of Adjuvant Therapy With Pegylated Interferon Alfa-2b Versus Observation in Resected Stage III Melanoma. Journal Of Clinical Oncology 2012; 30(31): 3810-3818. (AMC)

468. Eichhorn PJ, Rodon L, Gonzalez-Junca A, Dirac A, Gili M, Martinez-Saez E, Aura C, Barba I, Peg V, Prat A, Cuartas I, Jimenez J, Garcia-Dorado D, Sahuquillo J, Bernards R, Baselga J, Seoane J. USP15 stabilizes TGF-beta receptor I and promotes oncogenesis through the activation of TGF-beta signalling in glioblastoma. Nat Med 2012; 18: 429-35 (NKI)

469. El Oualid F, Hameed DS, et al. Synthesis of atypical diubiquitin chains. Methods Mol Biol 2012: 832: 597-609 (NKI) 470. Elias S, Grooters HG, Bausch- Goldbohm RA, van den Brandt PA, Kampman E, van Leeuwen FE, Peeters PH, de Vries E,

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Drugs and Drug Combinations. Current Pharmaceutical Design 2012; 18: 2811-2829. (VUmc) 473. Elvington M, Huang YX, Morgan BP, Qiao F, Van Rooijen N, Atkinson C, Tomlinson S. Atargeted complement-

dependent strategy to improve the outcome of mAb therapy, and characterization in a murine model of metastatic cancer. Blood 2012; 119: 6043-6051. (VUmc)

474. Emanuel RM, Dueck AC, Geyer HL, Kiladjian JJ, Slot S, Zweegman S, te Boekhorst PAW, Commandeur S, Schouten HC, Sackmann F, Fuentes AK, Hernandez-Maraver D, Pahl HL, Griesshammer M, Stegelmann F, Doehner K, Lehmann T, Bonatz K, Reiter A, Boyer F, Etienne G, Ianotto JC, Ranta D, Roy L, Cahn JY, Harrison CN, Radia D, Muxi P, Maldonado N, Besses C, Cervantes F, Johansson PL, Barbui T, Barosi G, Vannucchi AM, Passamonti F, Andreasson B, Ferarri ML, Rambaldi A, Samuelsson J, Birgegard G, Tefferi A, Mesa RA. Myeloproliferative Neoplasm (MPN) Symptom Assessment Form Total Symptom Score: Prospective International Assessment of an Abbreviated Symptom Burden Scoring System Among Patients With MPNs. J Clin Oncol 2012; 30: 4098-4103. (VUmc)

475. Emmering J, Vogel WV, Stokkel MP. Intramuscular metastases on FDG PETCT: a review of the literature. Nucl Med Commun 2012; 33: 117-20 (NKI)

476. Engel C, Loeffler M, Steinke V, Rahner N, Holinski-Feder E, Dietmaier W, Schackert HK, Goergens H, Doeberitz MV, Goecke TO, Schmiegel W, Buettner R, Moeslein G, Letteboer TGW, Garcia EG, Hes FJ, Hoogerbrugge N, Menko FH, Van Os TAM, Sijmons RH, Wagner A, Kluijt I, Propping P, Vasen HFA. Risks of Less Common Cancers in Proven Mutation Carriers With Lynch Syndrome. J Clin Oncol 2012; 30: 4409-4415. (VUmc)

477. Engelen V, Detmar S, Koopman H, Maurice-Stam H, Caron H, Hoogerbrugge P, Egeler RM, Kaspers G, Grootenhuis M. Reporting health-related quality of life scores to physicians during routine follow-up visits of pediatric oncology patients: is it effective? Pediatric Blood & Cancer 2012; 58(5): 766-774. (AMC/VUmc)

478. Engelen V, van Zwieten M, Koopman H, Detmar S, Caron H, Brons P, Egeler M, Kaspers G, Grootenhuis M. The influence of patient reported outcomes on the discussion of psychosocial issues in children with cancer. Pediatric Blood & Cancer 2012; 59(1): 161-166. (AMC/VUmc)

479. Englbrecht M, Gossec L, DeLongis A, Scholte-Voshaar M, Sokka T, Kvien TK, Schett G. The Impact of Coping Strategies on Mental and Physical Well-Being in Patients with Rheumatoid Arthritis. Seminars in Arthritis and Rheumatism 2012; 41: 545-555. (VUmc)

480. Eppink B, Krawczyk PM, Stap J, Kanaar R. Hyperthermia-induced DNA repair deficiency suggests novel therapeutic anti-cancer strategies. International Journal Of Hyperthermia 2012; 28(6): 509-517. (AMC)

481. Eppink B, Stalpers L, Kanaar R, Franken NAP. Hyperthermie. Kanker Breed 2012; 4(4): 21-24. (AMC) 482. Erdem L, Giovannetti E, Leon LG, Honeywell R, Peters GJ. Polymorphisms to Predict Outcome to the Tyrosine Kinase

Inhibitors Gefitinib, Erlotinib, Sorafenib and Sunitinib. Current Topics in Medicinal Chemistry 2012; 12: 1649-1659. (VUmc)

483. Escudier B, Osanto S, Ljungberg B, Porta C, Wagstaff J, Mulders P, et al. Multidisciplinary management of metastatic renal cell carcinoma in the era of targeted therapies. Cancer Treat Rev 2012; 38: 127-32

484. Eshuis WJ, van Dalen JW, Busch ORC, van Gulik TM, Gouma DJ. Route of gastroenteric reconstruction in pancreatoduodenectomy and delayed gastric emptying. HPB 2012; 14(1): 54-59. (AMC)

485. Etzrodt M, Cortez-Retamozo V, Newton A, Zhao J, Ng A, Wildgruber M, Romero P, Wurdinger T, Xavier R, Geissmann F, Meylan E, Nahrendorf M, Swirski FK, Baltimore D, Weissleder R, Pittet MJ. Regulation of Monocyte Functional Heterogeneity by miR-146a and Relb. Cell Reports 2012; 1: 317-324. (VUmc)

486. Evers DJ, Hendriks B, Lucassen G, Ruers T. Optical spectroscopy: current advances and future applications in cancer diagnostics and therapy. Future Oncol 2012; 8: 307-20 (NKI)

487. Evers DJ, Nachabé R, Klomp HM, van Sandick JW, Wouters MW, Lucassen GW, Hendriks BH, Wesseling J, Ruers TJ. Diffuse reflectance spectroscopy: a new guidance tool for improvement of biopsy procedures in lung malignancies. Clin Lung Cancer 2012; 13: 424-31 (NKI)

488. Evers DJ, Nachabe R, Vranken Peeters MJTFD, van der Hage J.A., Oldenburg H.S., Rutgers EJT, et al. Diffuse reflectance spectroscopy: towards clinical application in breast cancer. Breast Cancer Res Treat 2013; 137: 155-165 (NKI)

489. Everts V, Niehof A, Tigchelaar-Gutter W, Beertsen W. Transmission electron microscopy of bone. Methods In Molecular Biology (Clifton, N.J.) 2012; 816: 351-363. (AMC)

490. Ezzatizadeh V, Pinto RM, Sandi C, Sandi M, Al-Mahdawi S, Te Riele H, Pook MA. The mismatch repair system protects against intergenerational GAA repeat instability in a Friedreich ataxia mouse model. Neurobiol Dis 2012; 46: 165-71 (NKI)

491. Faber WR, Hoekzema R, Bart A, Zeegelaar JE, de Vries HJH. Cutaneous Leishmaniasis Acquired in Jura, France. Emerging Infectious Diseases 2012; 18: 183-184. (VUmc)

492. Faesen AC, Luna-Vargas MP, Sixma TK. The role of UBL domains in ubiquitinspecific proteases. Biochem Soc Trans 2012; 40: 539-45 (NKI)

493. Fahmi F, Marquering HA, Streekstra GJ, Beenen LFM, Velthuis BK, VanBavel E, Majoie CB. Differences in CT Perfusion Summary Maps for Patients with Acute Ischemic Stroke Generated by 2 Software Packages. American Journal Of Neuroradiology 2012; 33(11): 2074-2080. (AMC)


494. Fahner PJ, Legemate DA, van der Wal AC, van Marle J, Peters SLM, van Eck CF, van Gulik TM, Idu MM. Comparison of preserved vascular allografts using glycerol and University of Wisconsin solution in a goat carotid artery transplantation model. European Surgical Research 2012; 48(2): 64-72. (AMC)

495. Fairley JA, Mitchell LE, Berg T, Kenneth NS, von Schubert C, Sillje HH, Medema RH, Nigg EA, White RJ. Direct regulation of tRNA and 5S rRNA gene transcription by Polo-like kinase-1. Mol Cell 2012; 45: 541-52 (NKI)

496. Falke LL, Dendooven A, Leeuwis JW, Nguyen TQ, van Geest RJ, van der Giezen DM, Broekhuizen R, Lyons K, Stoop R, Kemperman H, Schlingemann R, Joles JA, Goldschmeding R. Hemizygous deletion of CTGF/CCN2 does not suffice to prevent fibrosis of the severely injured kidney. Matrix Biology 2012; 31(7-8): 421-431. (AMC)

497. Fang J, Rhyasen G, Bolanos L, Rasch C, Varney M, Wunderlich M, Goyama S, Jansen G, Cloos J, Rigolino C, Cortelezzi A, Mulloy JC, Oliva EN, Cuzzola M, Starczynowski DT. Cytotoxic effects of bortezomib in myelodysplastic syndrome/acute myeloid leukemia depend on autophagy-mediated lysosomal degradation of TRAF6 and repression of PSMA1. Blood 2012; 120: 858-867. (VUmc)

498. Farazi TA, Brown M, Morozov P, Ten Hoeve JJ, Ben-Dov IZ, Hovestadt V, Hafner M, Renwick N, Mihailovi A, Wessels LFA, Tuschl T. Bioinformatic analysis of barcoded cDNA libraries for small RNA profiling by next-generation sequencing. Methods 2012; 58: 171-87 (NKI)

499. Fasching PA, Pharoah PD, Cox A et al, and Schmidt MK. The role of genetic breast cancer susceptibility variants as prognostic factors. Hum Mol Genet 2012; 21: 3926-39 (NKI)

500. Fassnacht M, Terzolo M, Allolio B, Baudin E, Haak H, Berruti A, Welin S, Schade-Brittinger C, Lacroix A, Jarzab B, Sorbye H, Torpy DJ, Stepan V, Schteingart DE, Arlt W, Kroiss M, Leboulleux S, Sperone P, Sundin A, Hermsen I, Hahner S, Willenberg HS, Tabarin A, Quinkler M, de la Fouchardière C, Schlumberger M, Mantero F, Weismann D, Beuschlein F, Gelderblom H, Wilmink H, Sender M, Edgerly M, Kenn W, Fojo T, Müller H, Skogseid B. Combination chemotherapy in advanced adrenocortical carcinoma. New England Journal Of Medicine 2012; 366(23): 2189-2197. (AMC)

501. Feau S, Garcia Z, Arens R, Yagita H, Borst J, Schoenberger SP. The CD4+ T-cell help signal is transmitted form APC to CD8+ T-cells via CD27-CD70 interactions. Nat Comm 2012; 3: 948 (NKI)

502. Federico L, Ren H, et al. Autotaxin and its product lysophosphatidic acid suppress brown adipose differentiation and promote diet-induced obesity in mice. Mol Endocrinol 2012: 26: 786-797 (NKI)

503. Feeney ER, van Vonderen MGA, Wit F, Danner SA, van Agtmael MA, Villarroya F, Domingo P, Capeau J, Reiss P, Mallon PWG. Zidovudine/lamivudine but not nevirapine in combination with lopinavir/ritonavir decreases subcutaneous adipose tissue mitochondrial DNA. Aids 2012; 26: 2165-2174. (VUmc)

504. Feingold BJ, Silbergeld EK, Curriero FC, van Cleef BA, Heck ME, Kluytmans JA. Livestock density as risk factor for livestock-associated methicillin-resistant Staphylococcus aureus, the Netherlands. Emerg Infect Dis 2012; 18: 1841-1849. (VUmc)

505. Fennell DA. Response to chemotherapy is predictive in relation to longer overall survival in an individual patient combined-analysis with pleural mesothelioma. Eur J Cancer 2012; 48: 2983-92 (NKI)

506. Ferriolli E, Skipworth RJE, Hendry P, Scott A, Stensteth J, Dahele M, Wall L, Greig C, Fallon M, Strasser F, Preston T, Fearon KCH. Physical Activity Monitoring: A Responsive and Meaningful Patient-Centered Outcome for Surgery, Chemotherapy, or Radiotherapy?. Journal of Pain and Symptom Management 2012; 43: 1025-1035. (VUmc)

507. Ficarra V, Novara G, Ahlering TE, Costello A, Eastham JA, Graefen M, et al. Systematic review and metaanalysis of studies reporting potency rates after robot-assisted radical prostatectomy. Eur Urol 2012; 62: 418-30 (NKI)

508. Ficarra V, Novara G, Rosen RC, Artibani W, Carroll PR, Costello A, et al. Systematic review and metaanalysis of studies reporting urinary continence recovery after robotassisted radical prostatectomy. Eur Urol 2012; 62: 405-17 (NKI)

509. Ficarra V, Sooriakumaran P, Novara G, Schatloff O, Briganti A, Van der Poel H, et al. Systematic review of methods for reporting combined outcomes after radical prostatectomy and proposal of a novel system: the survival, continence, and potency (SCP) classification. Eur Urol 2012; 61: 541-8 (NKI)

510. Fieuw A, Kumps C, Schramm A, Pattyn F, Menten B, Antonacci F, Sudmant P, Schulte JH, van RN, Vergult S, Buckley PG, de Paepe A, Noguera R, Versteeg R, Stallings R, Eggert A, Vandesompele J, de Preter K, Speleman F. Identification of a novel recurrent 1q42.2-1qter deletion in high risk MYCN single copy 11q deleted neuroblastomas. International Journal Of Cancer 2012; 130(11): 2599-2606. (AMC)

511. Fijneman RJA, Anderson RA, Richards E, Liu JM, Tijssen M, Meijer GA, Anderson J, Rod A, O'Sullivan MG, Scott PM, Cormier RT. Runx1 is a tumor suppressor gene in the mouse gastrointestinal tract. Cancer Science 2012; 103: 593-599. (VUmc)

512. Fijneman RJA, de Wit M, Pourghiasian M, Piersma SR, Pham TV, Warmoes MO, Lavaei M, Piso C, Smit F, is-van Diemen PM, van Turenhout ST, Droste JSTS, Mulder CJJ, Blankenstein MA, Robanus-Maandag EC, Smits R, Fodde R, van Hinsbergh VWM, Meijer GA, Jimenez CR. Proximal Fluid Proteome Profiling of Mouse Colon Tumors Reveals Biomarkers for Early Diagnosis of Human Colorectal Cancer. Clin Cancer Res 2012; 18: 2613-2624. (VUmc)

513. Flach GB, Broglie MA, van Schie A, Bloemena E, Leemans CR, de Bree R, Stoeckli SJ. Sentinel node biopsy for oral and oropharyngeal squamous cell carcinoma in the previously treated neck. Oral Oncology 2012; 48: 85-89. (VUmc)

514. Fockens P. Endoscopic ultrasound-guided fine needle aspiration in cystic pancreatic lesions: is it still controversial? Reply. Endoscopy 2012; 44(1): 104-. (AMC)

515. Fockens P. Predictions of the past, prepared for the future? Netherlands Journal Of Medicine 2012; 70(5): 208-209. (AMC)

516. Fokkens WJ, Lund VJ, Mullol J, Bachert C, Alobid I, Baroody F, Cohen N, Cervin A, Douglas R, Gevaert P, Georgalas C, Goossens H, Harvey R, Hellings P, Hopkins C, Jones N, Joos G, Kalogjera L, Kern B, Kowalski M, Price D, Riechelmann H, Schlosser R, Senior B, Thomas M, Toskala E, Voegels R, Wang de Y, Wormald PJ. EPOS 2012: European position paper on rhinosinusitis and nasal polyps 2012. A summary for otorhinolaryngologists. Rhinology 2012; 50(1): 1-12. (AMC)

517. Fokkens WJ, Lund VJ, Mullol J, Bachert C, Alobid I, Baroody F, Cohen N, Cervin A, Douglas R, Gevaert P, Georgalas C, Goossens H, Harvey R, Hellings P, Hopkins C, Jones N, Joos G, Kalogjera L, Kern B, Kowalski M, Price D, Riechelmann H, Schlosser R, Senior B, Thomas M, Toskala E, Voegels R, Wang de Y, Wormald PJ. European Position Paper on Rhinosinusitis and Nasal Polyps 2012. Rhinology 2012; 50(Suppl. 23): 1 - 3 preceding table of contents 298. (AMC)

518. Fokkens WJ, van Drunen C, Georgalas C, Ebbens F. Role of fungi in pathogenesis of chronic rhinosinusitis: the hypothesis rejected. Current Opinion In Otolaryngology & Head And Neck Surgery 2012; 20(1): 19-23. (AMC)


519. Fontein DB, Nortier JW, Liefers GJ, Putter H, Meershoek-Klein Kranenbarg E, van den Bosch J, Maartense E, Rutgers EJT, van de Velde CJ. High non-compliance in the use of letrozole after 2.5 years of extended adjuvant endocrine therapy. Results from the IDEAL randomized trial. Eur J Surg Oncol 2012; 38: 110-7 (NKI)

520. Fortuin S, Kadouch DJM, Kadouch JA, Decates T, Markc KW, Karim RB. Use of audit to improve surgical treatment of facial basal cell carcinoma. European Journal Of Plastic Surgery 2012; G-. (AMC)

521. Frampton AE, Krell J, Giovannetti E, Krell D, Stebbing J, Castellano L, Jiao LR. Defining a prognostic molecular profile for ductal adenocarcinoma of the pancreas highlights known key signaling pathways. Expert Rev Anticancer Ther 2012; 12: 1275-1278. (VUmc)

522. Frampton AL, Krell J, Giovannetti E, Jiao LR, Stebbing J. Role of miRNAs in the response to anticancer therapy. Pharmacogenomics 2012; 13: 1663-1666. (VUmc)

523. Francissen CMTP, Dings PJM, van Dalen T, Strobbe LJA, van Laarhoven HWM, de Wilt JHW. Axillary recurrence after a tumor-positive sentinel lymph node biopsy without axillary treatment: a review of the literature. Annals Of Surgical Oncology 2012; 19(13): 4140-4149. (AMC)

524. Frank S, van Die I, Geyer R. Structural characterization of Schistosoma mansoni adult worm glycosphingolipids reveals pronounced differences with those of cercariae. Glycobiology 2012; 22: 676-695. (VUmc)

525. Franke NE, Niewerth D, Assaraf YG, van Meerloo J, Vojtekova K, van Zantwijk CH, Zweegman S, Chan ET, Kirk CJ, Geerke DP, Schimmer AD, Kaspers GJL, Jansen G, Cloos J. Impaired bortezomib binding to mutant beta 5 subunit of the proteasome is the underlying basis for bortezomib resistance in leukemia cells. Leukemia 2012; 26: 757-768. (VUmc)

526. Franken NAP, Hovingh S, ten Cate R, Krawczyk P, Stap J, Hoebe R, Aten J, Barendsen GW. Relative biological effectiveness of high linear energy transfer α-particles for the induction of DNA-double-strand breaks, chromosome aberrations and reproductive cell death in SW-1573 lung tumour cells. Oncology Reports 2012; 27(3): 769-774. (AMC)

527. Franssen R, Schimmel AWM, van Leuven SI, Wolfkamp SCS, Stroes ESG, Dallinga-Thie GM. In Vivo Inflammation Does Not Impair ABCA1-Mediated Cholesterol Efflux Capacity of HDL. CHOLESTEROL 2012; 2012: 610741-. (AMC)

528. Franzke CW, Cobzaru C, Triantafyllopoulou A, Loffek S, Horiuchi K, Threadgill DW, Kurz T, Van Rooijen N, Bruckner-Tuderman L, Blobel CP. Epidermal ADAM17 maintains the skin barrier by regulating EGFR ligand-dependent terminal keratinocyte differentiation. Journal of Experimental Medicine 2012; 209: 1105-1119. (VUmc)

529. Frederix GW, Severens JL, Hövels AM, Raaijmakers JA, Schellens JH. Reviewing the cost-effectiveness of endocrine early breast cancer therapies: influence of differences in modeling methods on outcomes. Value Health 2012; 15: 94-105 (NKI)

530. French VM, van de Laar IMBH, Wessels MW, Rohe C, Roos-Hesselink JW, Wang G, Frohn-Mulder IME, Severijnen L, de Graaf BM, Schot R, Breedveld G, Mientjes E, van Tienhoven M, Jadot E, Jiang Z, Verkerk A, Swagemakers S, Venselaar H, Rahimi Z, Najmabadi H, Meijers-Heijboer H, de Graaff E, Helbing WA, Willemsen R, Devriendt K, Belmont JW, Oostra BA, Amack JD, Bertoli-Avella AM. NPHP4 variants are associated with pleiotropic heart malformations. Circulation Research 2012; 110(12): 1564-1574. (AMC)

531. Frijns E, Kuikman I, Litjens S, Raspe M, Jalink K, Ports M, Wilhelmsen K, Sonnenberg A. Phosphorylation of threonine 1736 in the C-terminal tail of integrin b4 contributes to hemidesmosome disassembly. Mol Biol Cell 2012; 23: 1475-85 (NKI)

532. Frijns E. Controling hemidesmosome dynamics by phosphorylation of the integrin b4 subunit. PhD thesis. Amsterdam: University of Amsterdam, 2012 (NKI)

533. Fuller A, Razvi H, Denstedt JD, Nott L, Pearle M, Cauda F, Bolton D, Celia A, de la Rosette J. The CROES percutaneous nephrolithotomy global study: the influence of body mass index on outcome. Journal Of Urology 2012; 188(1): 138-144. (AMC)

534. Furukawa T, Kloeppel G, Adsay V, Albores-Saavedra J, Fukushima N, Horii A, Hruban RH, Kato Y, Klimstra DS, Longnecker DS, Luettges J, Offerhaus GJA, Shimizu M, Sunamura M, Suriawinata A, Takaori K, Yonezawa S. Classification of types of intraductal papillary-mucinous neoplasm of the pancreas: a consensus study (vol 447, pg 794, 2005). Virchows Archiv 2012; 461(3): 351-. (AMC)

535. Gabriels K, Hoving S, Seemann I, Visser NL, Gijbels MJ, Pol JF, Daemen MJ, Stewart FA, Heeneman S. Local heart irradiation of ApoE-/- mice increases inflammation and causes endocardial damage with modest changes in cardiac function. Radiother Oncol 2012; 105: 358-364 (NKI)

536. Gafter-Gvili A, Fraser A, Paul M, Vidal L, Lawrie TA, van de Wetering MD, Kremer LCM, Leibovici L. Antibiotic prophylaxis for bacterial infections in afebrile neutropenic patients following chemotherapy. Cochrane Database Of Systematic Reviews 2012; 2012(1): CD004386-. (AMC)

537. Gallagher SJ, Kofman AE, Huszar JM, Dannenberg JH, Depinho RA, Braun RE, Payne CJ. Distinct requirements for Sin3a in perinatal male gonocytes and differentiating spermatogonia. Dev Biol. 2012 (NKI)

538. Galvani E, Peters GJ, Giovannetti E. EGF receptor-targeted therapy in non-small-cell lung cancer: role of germline polymorphisms in outcome and toxicity. Future Oncology 2012; 8: 1015-1029. (VUmc)

539. Gans SL, van Westreenen HL, Kiewiet JJS, Rauws EAJ, Gouma DJ, Boermeester MA. Systematic review and meta-analysis of somatostatin analogues for the treatment of pancreatic fistula. British Journal Of Surgery 2012; 99(6): 754-760. (AMC)

540. Garaude J, Kent A, Van Rooijen N, Blander JM. Simultaneous Targeting of Toll- and Nod-Like Receptors Induces Effective Tumor-Specific Immune Responses. Science Translational Medicine 2012; 4: . (VUmc)

541. Garcia Z, Lemaitre F, Van Rooijen N, Albert ML, Levy Y, Schwartz O, Bousso P. Subcapsular sinus macrophages promote NK cell accumulation and activation in response to lymph-borne viral particles. Blood 2012; 120: 4744-4750. (VUmc)

542. Gautier EL, Chow A, Spanbroek R, Marcelin G, Greter M, Jakubzick C, Bogunovic M, Leboeuf M, Van Rooijen N, Habenicht AJ, Merad M, Randolph GJ. Systemic Analysis of PPAR gamma in Mouse Macrophage Populations Reveals Marked Diversity in Expression with Critical Roles in Resolution of Inflammation and Airway Immunity. J Immunol 2012; 189: 2614-2624. (VUmc)

543. Gawecka JE, Geerts D, Koster J, Caliva MJ, Sulzmaier FJ, Opoku-Ansah J, Wada RK, Bachmann AS, Ramos JW. PEA15 impairs cell migration and correlates with clinical features predicting good prognosis in neuroblastoma. International Journal Of Cancer 2012; 131(7): 1556-1568. (AMC)

544. Geel Nanja van, Speeckaert Reinhart, Mollet Ilse, Schepper Sofie De, Wolf Julie De, Tjin Esther P. M., Luiten Rosalie M., Lambert Jo, Brochez Lieve: In vivo vitiligo induction and therapy model: double-blind, randomized clinical trial. PIGMENT CELL & MELANOMA RESEARCH 25(1), 2012, p.57-65.


545. Geersing G, Erkens PMG, Lucassen WAM, Büller HR, ten Cate H, Hoes AW, Moons KGM, Prins MH, Oudega R, van Weert HCPM, Stoffers HEJH. Safe exclusion of pulmonary embolism using the Wells rule and qualitative D-dimer testing in primary care: prospective cohort study. British Medical Journal 2012; 345: e6564-. (AMC)

546. Gent YYJ, Voskuyl AE, Kloet RW, van Schaardenburg D, Hoekstra OS, Dijkmans BAC, Lammertsma AA, van der Laken CJ. Macrophage positron emission tomography imaging as a biomarker for preclinical rheumatoid arthritis: Findings of a prospective pilot study. Arthritis and Rheumatism 2012; 64: 62-66. (VUmc)

547. Georgalas C, Badloe R, van Furth W, Reinartz S, Fokkens WJ. Quality of life in extended endonasal approaches for skull base tumours. Rhinology 2012; 50(3): 255-261. (AMC)

548. Georgalas C, Jovancevic L. Gustatory rhinitis. Current Opinion In Otolaryngology & Head And Neck Surgery 2012; 20(1): 9-14. (AMC)

549. Gerlag DM, Raza K, van Baarsen LGM, Brouwer E, Buckley CD, Burmester GR, Gabay C, Catrina AI, Cope AP, Cornelis F, Dahlqvist SR, Emery P, Eyre S, Finckh A, Gay S, Hazes JM, van der Helm-van Mil, Huizinga TWJ, Klareskog L, Kvien TK, Lewis C, Machold KP, Ronnelid J, van Schaardenburg D, Schett G, Smolen JS, Thomas S, Worthington J, Tak PP. EULAR recommendations for terminology and research in individuals at risk of rheumatoid arthritis: report from the Study Group for Risk Factors for Rheumatoid Arthritis. Annals of the Rheumatic Diseases 2012; 71: 638-641. (VUmc)

550. Gerritsen WR, Sharma P. Current and Emerging Treatment Options for Castration-Resistant Prostate Cancer: A Focus on Immunotherapy. Journal of Clinical Immunology 2012; 32: 25-35. (VUmc)

551. Gerritsen WR. The evolving role of immunotherapy in prostate cancer. Annals of Oncology 2012; 23: 22-27. (VUmc) 552. Geurink PP, El Oualid F, et al. A general chemical ligation approach towards isopeptide-linked ubiquitin and ubiquitin-

like assay reagents. Chembiochem 2012: 13: 293-297 (NKI) 553. Geutjes EJ, Bajpe PK, Bernards R. Targeting the epigenome for treatment of cancer. Oncogene 2012; 31: 3827-44 554. Geutjes EJ, Tian S, Roepman P, Bernards R. Deoxycytidine kinase is overexpressed in poor outcome breast cancer and

determines responsiveness to nucleoside analogs. Breast Cancer Res Treat 2012; 131: 809-18 (NKI) 555. Geutjes P, Roelofs L, Hoogenkamp H, Walraven M, Kortmann B, de Gier R, Farag F, Tiemessen D, Sloff M, Oosterwijk

E, van Kuppevelt T, Daamen W, Feitz W. Tissue Engineered Tubular Construct for Urinary Diversion in a Preclinical Porcine Model. Journal of Urology 2012; 188: 653-660. (VUmc)

556. Geyer FC, Lacroix-Triki M, Colombo PE, Patani N, Gauthier A, Natrajan R, Lambros MB, Khalifeh I, Albarracin C, Orru S, Marchio C, Sapino A, Mackay A, Weigelt B, Schmitt FC, Wesseling J, Sneige N, Reis-Filho JS. Molecular evidence in support of the neoplastic and precursor nature of microglandular adenosis. Histopathology 2012; 60: E115-30 (NKI)

557. Ghoussaini M, Fletcher O, Michailidou K et al. Genome-wide association analysis identifies three new breast cancer susceptibility loci. Nat Genet 2012; 44: 312-8 (NKI/AMC/VUmc)

558. Gille JJP, Floor K, Kerkhoven L, Ameziane N, Joenje H, de Winter JP. Diagnosis of Fanconi Anemia: Mutation Analysis by Multiplex Ligation-Dependent Probe Amplification and PCR-Based Sanger Sequencing. Anemia 2012; 2012: 603253. (VUmc)

559. Gillison ML, Alemany L, Snijders PJF, Chaturvedi A, Steinberg BM, Schwartz S, Castellsague X. Human papillomavirus and diseases of the upper airway: head and neck cancer and respiratory papillomatosis. Vaccine 2012; : F34-F54. (VUmc)

560. Giovannetti E, Codacci-Pisanelli G, Peters GJ. TFAP2E-DKK4 and Chemoresistance in Colorectal Cancer. New England Journal of Medicine 2012; 366: 966. (VUmc)

561. Giovannetti E, Erozenci A, Smit J, Danesi R, Peters GJ. Molecular mechanisms underlying the role of microRNAs (miRNAs) in anticancer drug resistance and implications for clinical practice. Critical Reviews in Oncology Hematology 2012; 81: 103-122. (VUmc)

562. Giovannetti E, Toffalorio F, De Pas T, Peters GJ. Pharmacogenetics of conventional chemotherapy in non-small-cell lung cancer: a changing landscape?. Pharmacogenomics 2012; 13: 1073-1086. (VUmc)

563. Giovannetti E, van der Velde A, Funel N, Vasile E, Perrone V, Leon LG, De Lio N, Avan A, Caponi S, Pollina LE, Galla V, Sudo H, Falcone A, Campani D, Boggi U, Peters GJ. High-Throughput MicroRNA (miRNAs) Arrays Unravel the Prognostic Role of MiR-211 in Pancreatic Cancer. PloS one 2012; 7: e49145. (VUmc)

564. Giske CG, Jonkers J. Editorial. Drug Resist Updat 2012; 15: 1 (NKI) 565. Gliem M, Hermsen D, Van Rooijen N, Hartung HP, Jander S. Secondary Intracerebral Hemorrhage Due to Early

Initiation of Oral Anticoagulation After Ischemic Stroke An Experimental Study in Mice. Stroke 2012; 43: 3352-3357. (VUmc)

566. Gliem M, Mausberg AK, Lee JI, Simiantonakis I, Van Rooijen N, Hartung HP, Jander S. Macrophages prevent hemorrhagic infarct transformation in murine stroke models. Ann Neurol 2012; 71: 743-752. (VUmc)

567. Godefroy WP, Klop WM, Smeele LE, Lohuis PJ. Free-flap reconstruction of large full-thickness lip and chin defects. Ann Otol Rhinol Laryngol 2012; 121: 594-603 (NKI)

568. Goede J, Weijerman ME, Broers CJM, de Winter JP, van der Voort-Doedens L, Hack WWM. Testicular Volume and Testicular Microlithiasis in Boys With Down Syndrome. Journal of Urology 2012; 187: 1012-1017. (VUmc)

569. Gok M, Heideman DAM, van Kemenade FJ, de Vries ALM, Berkhof J, Rozendaal L, Belien JAM, Overbeek L, Babovic M, Snijders PJF, Meijer CJLM. Offering self-sampling for human papillomavirus testing to non-attendees of the cervical screening programme: Characteristics of the responders. European Journal of Cancer 2012; 48: 1799-1808. (VUmc)

570. Gok M, van Kemenade FJ, Heideman DAM, Berkhof J, Rozendaal L, Spruyt JWM, Belien JAM, Babovic M, Snijders PJF, Meijer CJLM. Experience with high-risk human papillomavirus testing on vaginal brush-based self-samples of non-attendees of the cervical screening program. International Journal of Cancer 2012; 130: 1128-1135. (VUmc)

571. Gonzalez IT, Barrientos G, Freitag N, Otto T, Thijssen VLJL, Moschansky P, von Kwiatkowski P, Klapp BF, Winterhager E, Bauersachs S, Blois SM. Uterine NK Cells Are Critical in Shaping DC Immunogenic Functions Compatible with Pregnancy Progression. PloS one 2012; 7: . (VUmc)

572. Goossens-Laan CA, Visser O, Hulshof MCCM, Wouters MW, Bosch JLHR, Coebergh JW, Kil PJM. Survival after treatment for carcinoma invading bladder muscle: a Dutch population-based study on the impact of hospital volume. BJU International 2012; 110(2): 226-232. (AMC)

573. Gordijn MS, Gemke RJBJ, van Dalen EC, Rotteveel J, Kaspers GJL. Hypothalamic-pituitary-adrenal (HPA) axis suppression after treatment with glucocorticoid therapy for childhood acute lymphoblastic leukaemia. Cochrane Database Of Systematic Reviews 2012; 2012(5): CD008727-. (AMC/VUmc)

574. Gordijn MS, van Litsenburg RR, Gemke RJBJ, Bierings MB, Hoogerbrugge PM, van de Ven PM, Heijnen CJ, Kaspers GJL. Hypothalamic-pituitary-adrenal axis function in survivors of childhood acute lymphoblastic leukemia and healthy controls. Psychoneuroendocrinology 2012; 37: 1448-1456. (VUmc)


575. Gouma DJ, Laméris HJS, Rauws EAJ, Busch ORC. Centralisatie van hoogcomplexe chirurgie. Nederlands Tijdschrift Voor Geneeskunde 2012; 156(32): A4887-. (AMC)

576. Govaert KM, van Kessel CS, Lolkema M, Ruers TJ, Borel Rinkes IH. Does Radiofrequency Ablation Add to Chemotherapy for Unresectable Liver Metastases? Curr Colorectal Cancer Rep 2012; 8: 130-137 (NKI)

577. Graf N, van Tinteren H, Bergeron C, Pein F, van den Heuvel-Eibrink MM, Sandstedt B, Schenk JP, Godzinski J, Oldenburger F, Furtwangler R, de Kraker J. Characteristics and outcome of stage II and III non-anaplastic Wilms’ tumour treated according to the SIOP trial and study 93-01. Eur J Cancer 2012; 48: 3240-3248 (NKI)

578. Gravas S, Montanari E, Geavlete P, Onal B, Skolarikos A, Pearle M, Sun YH, de la Rosette J. Postoperative infection rates in low risk patients undergoing percutaneous nephrolithotomy with and without antibiotic prophylaxis: a matched case control study. Journal Of Urology 2012; 188(3): 843-847. (AMC)

579. Gravas S, Tzortzis V, Martinez de la Riva Santiago I, Laguna P, de la Rosette J. Focal therapy for prostate cancer: patient selection and evaluation. Expert Review Of Anticancer Therapy 2012; 12(1): 77-86. (AMC)

580. Graveland AP, Braakhuis BH, Eerenstein SE, de Bree R, Bloemena E, de Maaker M, Van den Brekel MW, Dijk F, Mesker WE, Tanke HJ, Leemans CR, Brakenhoff RH. Molecular diagnosis of minimal residual disease in head and neck cancer patients. Cell Oncol 2012; 35: 367-75 (NKI/VUmc)

581. Green NK, Hale A, Cawood R, Illingworth S, Herbert C, Hermiston T, Subr V, Ulbrich K, Van Rooijen N, Seymour LW, Fisher KD. Tropism ablation and stealthing of oncolytic adenovirus enhances systemic delivery to tumors and improves virotherapy of cancer. Nanomedicine 2012; 7: 1683-1695. (VUmc)

582. Greenberg PL, Tuechler H, Schanz J, Sanz G, Garcia-Manero G, Sole F, Bennett JM, Bowen D, Fenaux P, Dreyfus F, Kantarjian H, Kuendgen A, Levis A, Malcovati L, Cazzola M, Cermak J, Fonatsch C, Le Beau MM, Slovak ML, Krieger O, Luebbert M, Maciejewski J, Magalhaes SMM, Miyazaki Y, Pfeilstocker M, Sekeres M, Sperr WR, Stauder R, Tauro S, Valent P, Vallespi T, van de Loosdrecht AA, Germing U, Haase D. Revised International Prognostic Scoring System for Myelodysplastic Syndromes. Blood 2012; 120: 2454-2465. (VUmc)

583. Gregori D, Foltran F, Ballali S, Berchialla P, Rodriguez H, Zaupa P, Spitzer P, Demetriades C, Slapak I, Sokolova L, Petridou E, D'Alessandro A, Clemente MACP, Jakubikova J, Van As S, De Koning T, Passali D, Chinsky A, Rodriguez H, Brkic F, Mladina R, Kalakouta O, Melis A, Machalova M, Caye-Thomasen P, Elsheikh E, Ragab A, Pitkaranta A, Necker PC, Derelle J, Duwelz M, Francois M, Pezzettigotta S, Righini C, Stephane P, Buzarov J, Bernhard R, Jahnke V, Onder G, Zieriacks P, Kalampoki V, Simasko N, Skoulakis C, Camaioni A, Cutrone C, Gaudini E, Grasso D, Mansi N, Messi G, Orlando C, Preziosi S, Sorrentini I, Trozzi M, Vigo A, Villari G, Passali GC, Passali FM, Nishida Y, Ussatayeva G, De Hoyos R, Ologe FE, Nasrullah M, Melendez A, Chmielik M, Belchior T, Cobzeanu MD, Gheorghe DC, Lorgulescu A, Caius C, Toader M, Barkociova J, Havelkova B, Zargi M, Pumarola F, Rubio L, Stierna P, Hsu WC, rj-Ong S, Chomchai C, Hoep L, Rinkel R, Baskent EA, Erikci VS, Onerci M, Graham J, Khwaja S, Raine C. The Susy Safe project overview after the first four years of activity. International Journal of Pediatric Otorhinolaryngology 2012; 76: S3-S11. (VUmc)

584. Greijer AE, Stevens SJ, Verkuijlen SA, Juwana H, Fleig SC, Verschuuren EA, Hepkema BG, Cornelissen JJ, Brooimans RA, Verdonck LF, Middeldorp JM. Variable EBV DNA Load Distributions and Heterogeneous EBV mRNA Expression Patterns in the Circulation of Solid Organ versus Stem Cell Transplant Recipients. Clinical & Developmental Immunology 2012; : . (VUmc)

585. Griffioen AW, Mans LA, de Graaf AM, Nowak-Sliwinska P, de Hoog CL, de Jong TA, et al. Rapid angiogenesis onset after discontinuation of sunitinib treatment of renal cell carcinoma patients. Clinical cancer research : an official journal of the American Association for Cancer Research 2012; 18: 3961-71 (VUmc/NKI)

586. Griffith M, Mwenifumbo JC, Cheung PY, Paul JE, Pugh TJ, Tang MJ, Chittaranjan S, Morin RD, Asano JK, Ally AA, Miao L, Lee A, Chan SY, Taylor G, Severson T, Hou YC, Griffith OL, Cheng GS, Novik K, Moore R, Luk M, Owen D, Brown CJ, Morin GB, Gill S, Tai IT, Marra MA. Novel mRNA isoforms and mutations of uridine monophosphate synthetase and 5-fluorouracil resistance in colorectal cancer. Pharmacogenomics J. 2012 (NKI)

587. Grills IS, Hope AJ, Guckenberger M, Kestin LL, Werner-Wasik M, Yan D, Sonke JJ, Bissonnette JP, Wilbert J, Xiao Y, Belderbos J. A collaborative analysis of stereotactic lung radiotherapy outcomes for early-stage non-small-cell lung cancer using daily online cone-beam computed tomography image-guided radiotherapy. J Thorac Oncol 2012; 7: 1382-93 (NKI)

588. Groenendaal G, Borren A, Moman MR, Monninkhof E, van Diest PJ, Philippens ME, van Vulpen M, van der Heide UA. Pathologic validation of a model based on diffusion-weighted imaging and dynamic contrast-enhanced magnetic resonance imaging for tumor delineation in the prostate peripheral zone. Int J Radiat Oncol Biol Phys 2012; 82: e537-44 (NKI)

589. Groenendaal G, van Vulpen M, Pereboom SR, Poelma-Tap D, Korporaal JG, Monninkhof E, van der Heide UA. The effect of hormonal treatment on conspicuity of prostate cancer: implications for focal boosting radiotherapy. Radiother Oncol 2012; 103: 233-8 (NKI)

590. Groenendijk MR, Thunnissen E, Ylstra B, van de Wiel MA, Eijk PP, Paul MA, Smit EF, Postmus PE. An 82-Year-Old Woman With Small-Cell Lung Cancer: Relapse After 9 Years or a New Primary?. Journal of Thoracic Oncology 2012; 7: E3-E5. (VUmc)

591. Groeneveld E, Lambers MJ, Stakelbeek MEF, Mooij TM, Belt-Dusebout AW, Heymans MW, Schats R, Hompes PGA, Hoek A, Burger CW, van Leeuwen FE, Lambalk CB. Factors associated with dizygotic twinning after IVF treatment with double embryo transfer. Human Reproduction 2012; 27: 2966-2970 (NKI)

592. Groeneveld IF, de Boer AGEM, Frings-Dresen MHW. A multidisciplinary intervention to facilitate return to work in cancer patients: intervention protocol and design of a feasibility study. BMJ Open 2012; 2(4): e001321-. (AMC)

593. Groeneveld IF, Sosa ES, Pérez M, Fiuza-Luces C, Gonzalez-Saiz L, Gallardo C, López-Mojares LM, Ruiz JR, Lucia A. Health-related quality of life of Spanish children with cystic fibrosis. Quality Of Life Research 2012; 21(10): 1837-1845. (AMC)

594. Groenewegen G, Walraven M, Vermaat J, de Gast B, Witteveen E, Giles R, Haanen J, Voest E. Targeting the endothelin axis with atrasentan, in combination with IFN-alpha, in metastatic renal cell carcinoma. Br J Cancer 2012; 106: 284-9 (NKI/VUmc)

595. Grootendorst DJ, Jose J, Wouters MW, van Boven H, van der Hage J, van Leeuwen TG, Steenbergen W, Manohar S, Ruers TJM. First experiences of photoacoustic imaging for detection of melanoma metastases in resected human lymph nodes. Lasers In Surgery And Medicine 2012; 44(7): 541-549. (AMC/NKI)

596. Grugan KD, Mccabe FL, Kinder M, Greenplate AR, Harman BC, Ekert JE, Van Rooijen N, Anderson GM, Nemeth JA, Strohl WR, Jordan RE, Brezski RJ. Tumor-Associated Macrophages Promote Invasion while Retaining Fc-Dependent Anti-Tumor Function. J Immunol 2012; 189: 5457-5466. (VUmc)


597. Grünwald V, Karakiewicz PI, Bavbek SE, Miller K, Machiels JP, Lee SH, Larkin J, Bono P, Rha SY, Castellano D, Blank CU, Knox JJ, Hawkins R, Anak O, Rosamilia M, Booth J, Pirotta N, Bodrogi I; REACT Study Group. An international expanded-access programme of everolimus: addressing safety and efficacy in patients with metastatic renal cell carcinoma who progress after initial vascular endothelial growth factor receptortyrosine kinase inhibitor therapy. Eur J Cancer 2012; 48: 324-32 (NKI)

598. Guckenberger M, Kestin LL, Hope AJ, Belderbos J, Werner-Wasik M, Yan D, Sonke JJ, Bissonnette JP, Wilbert J, Xiao Y, Grills IS. Is there a lower limit of pretreatment pulmonary function for safe and effective stereotactic body radiotherapy for early-stage nonsmall cell lung cancer? J Thorac Oncol 2012; 7: 542-51 (NKI)

599. Gude WT, Simon ACR., Peute LWP, Holleman F, Hoekstra JBL, Peek N, Jaspers MWM. Formative usability evaluation of a web-based insulin self-titration system: preliminary results. Studies In Health Technology And Informatics 2012; 180: 1209-1211. (AMC)

600. Gudlaugsson E, Skaland I, Janssen EAM, Smaaland R, Shao ZM, Malpica A, Voorhorst F, Baak JPA. Comparison of the effect of different techniques for measurement of Ki67 proliferation on reproducibility and prognosis prediction accuracy in breast cancer. Histopathology 2012; 61: 1134-1144. (VUmc)

601. Guiu S, Michiels S, André F, Cortes J, Denkert C, Di Leo A, Hennessy BT, Sorlie T, Sotiriou C, Turner N, van de Vijver M, Viale G, Loi S, Reis-Filho JS. Molecular subclasses of breast cancer: how do we define them? The IMPAKT 2012 Working Group Statement. Annals Of Oncology 2012; 23(12): 2997-3006. (AMC)

602. Gul N, Grewal S, Bogels M, van der Bij GJ, Koppes MM, Oosterling SJ, Fluitsma DM, Hoeben KA, Beelen RH, van Egmond M. Macrophages mediate colon carcinoma cell adhesion in the rat liver after exposure to lipopolysaccharide. Oncoimmunology 2012; 1: 1517-1526. (VUmc)

603. Gundy CM, Fayers PM, Groenvold M, Petersen MA, Scott NW, Sprangers MAG, Velikova G, Aaronson NK. Comparing higher order models for the EORTC QLQ-C30. Qual Life Res 2012; 21: 1607-17 (NKI)

604. Gurney BAS, Schilling C, Putcha V, Alkureishi LW, Alvarez AJ, Bakholdt V, Herrero LB, Barzan L, Bilde A, Bloemena E, Salces CC, Palma PD, de Bree R, Dequanter D, Dolivet G, Donner D, Flach GB, Fresno M, Grandi C, Haerle S, Huber GF, Hunter K, Lawson G, Leroux A, Lothaire PH, Mamelle G, Silini EM, Mastronicola R, Odell EW, O'Doherty MJ, Poli T, Rahimi S, Ross GL, Zuazua JS, Santini S, Sebbesen L, Shoaib T, Sloan P, Sorensen JA, Soutar DS, Therkildsen MH, Vigili MG, Villarreal PM, von Buchwald C, Werner JA, Wiegand S, McGurk M. Implications of a positive sentinel node in oral squamous cell carcinoma. Head and Neck-Journal for the Sciences and Specialties of the Head and Neck 2012; 34: 1580-1585. (VUmc)

605. Haan AMSG, Pans SJA, Lensen KDF, Meijerink MR, Comans EFI, Smulders YM. Vasculitis revealed by posterior stroke. Netherlands Journal of Medicine 2012; 70: 81-83. (VUmc)

606. Haan JC, Buffart TE, Eijk PP, van de Wiel MA, van Wieringen WN, Howdle PD, Mulder CJJ, van de Velde CJ, Quirke P, Nagtegaal ID, van Grieken NCT, Grabsch H, Meijer GA, Ylstra B. Small bowel adenocarcinoma copy number profiles are more closely related to colorectal than to gastric cancers. Annals of Oncology 2012; 23: 367-U344. (VUmc)

607. Haanen H, Blank CU. Immunomodulatory Drugs and Cytokines. ESMO handboek Clinical Pharmacology of Anti-cancer Agents, 2012 (NKI)

608. Haanstra Jasmijn F, de Vos tot Nederveen Cappel WH, Gopie JP, Vecht J, Vanhoutvin SALW, Cats A, van der Zaag-Loonen HJ, Langers AMJ, Bergmann JHW, van de Meeberg PC, Dekker E, Kleibeuker JH, Vasen HFA, Nagengast FM, van Duijvendijk P. Quality of life after surgery for colon cancer in patients with Lynch syndrome: partial versus subtotal colectomy. Diseases Of The Colon & Rectum 2012; 55(6): 653-659. (AMC/NKI)

609. Haas RL, Delaney TF, O’Sullivan B, Keus RB, Le Pechoux C, Olmi P, Poulsen JP, Seddon B, Wang D. Radiotherapy for management of extremity soft tissue sarcomas: Why, when, and where? Int J Radiat Oncol Biol Phys 2012; 84: 572-80 (NKI)

610. Haasbeek CJA, Palma D, Visser O, Lagerwaard FJ, Slotman B, Senan S. Early-stage lung cancer in elderly patients: A population-based study of changes in treatment patterns and survival in the Netherlands. Annals of Oncology 2012; 23: 2743-2747. (VUmc)

611. Hacker NF, Eifel PJ, van der Velden J. Cancer of the vagina. International Journal Of Gynecology & Obstetrics 2012; 119(Suppl. 2): S97-S99. (AMC)

612. Hacker NF, Eifel PJ, van der Velden J. Cancer of the vulva. International Journal Of Gynecology & Obstetrics 2012; 119(Suppl. 2): S90-S96. (AMC)

613. Hadj JO, Den Braven R, Tillier C, Schrijver HM, Verheul HMW, van der Vliet HJ. Reversible posterior leukoencephalopathy syndrome during sunitinib therapy for metastatic renal cell carcinoma. Oncology Letters 2012; 3: 1293-1296. (VUmc)

614. Hageman IMG, Peek AML, de Haas V, men-Korbijn CM, Kaspers GJL. Value of routine bone marrow examination in pediatric acute myeloid leukemia (AML): A study of the Dutch Childhood Oncology Group (DCOG). Pediatric Blood & Cancer 2012; 59: 1239-1244. (VUmc)

615. Hagenbeek A. Brentuximab Vedotin (Adcetris) bij de behandeling van het Hodgkin lymfoom. Een doorbraak? Nederlands Tijdschrift Voor Hematologie 2012; 9: 124-. (AMC)

616. Hahn D, Bleiker E, Woerdeman L, Emmel R. Tepel-transplantatie bij directe borstreconstructie. Eerste ervaringen met nipple banking. Psychosociale Oncologie 2012; 20: 18 (NKI)

617. Haigentz M, Hartl DM, Silver CE, Langendijk JA, Strojan P, Paleri V, de Bree R, Machiels JP, Hamoir M, Rinaldo A, Paccagnella D, Shaha AR, Takes RP, Ferlito A. Distant metastases from head and neck squamous cell carcinoma. Part III. Treatment. Oral Oncology 2012; 48: 787-793. (VUmc)

618. Haimovitz-Friedman A, Yang TI, Thin TH, Verheij M. Imaging radiotherapyinduced apoptosis. Radiat Res 2012; 177: 467-82 (NKI)

619. Halaby T, Reuland AE, al Naiemi N, Potron A, Savelkoul PHM, Vandenbroucke-Grauls CMJE, Nordmann P. A Case of New Delhi Metallo-beta-Lactamase 1 (NDM-1)-Producing Klebsiella pneumoniae with Putative Secondary Transmission from the Balkan Region in the Netherlands. Antimicrobial Agents and Chemotherapy 2012; 56: 2790-2791. (VUmc)

620. Halkes CJ, Brand A, Backes E, van Oers MH, Veelken JH, Falkenburg JH. Eerstelijnsbehandeling met immuunsuppressieve therapie bij ernstige aplastische anemie: polyklonale antistoffen zijn niet zonder meer inwisselbaar. Nederlands Tijdschrift Voor Hematologie 2012; 9: 263-. (AMC)

621. Ham JC, Janssen JJWM, Boers JE, Kluin PM, Verdonck LF. Allogeneic Stem-Cell Transplantation for Blastic Plasmacytoid Dendritic Cell Neoplasm. J Clin Oncol 2012; 30: E102-E103. (VUmc)

622. Hamming-Vrieze O, van Kranen SR, van Beek S, Heemsbergen W, van Herk M, van den Brekel MWM, Sonke J, Rasch CRN. Evaluation of tumor shape variability in head-and-neck cancer patients over the course of radiation therapy


using implanted gold markers. International Journal Of Radiation Oncology Biology Physics 2012; 84(2): e201-e207. (AMC/NKI)

623. Hangalapura BN, Timares L, Oosterhoff D, Scheper RJ, Curiel DT, de Gruijl TD. CD40-targeted adenoviral cancer vaccines: the long and winding road to the clinic. Journal of Gene Medicine 2012; 14: 416-427. (VUmc)

624. Hanna GG, van Sornsen de Koste JR, Dahele MR, Carson KJ, Haasbeek CJA, Migchielsen R, Hounsell AR, Senan S. Defining target volumes for stereotactic ablative radiotherapy of early-stage lung tumours: a comparison of three-dimensional 18F-fluorodeoxyglucose positron emission tomography and four-dimensional computed tomography. Clinical Oncology 2012; 24: e71-e80. (VUmc)

625. Hansen FS, Hoffmans R, Georgalas C, Fokkens WJ. Complicaties van acute rinosinusitis worden niet voorkómen door antibiotica*. Nederlands Tijdschrift Voor Geneeskunde 2012; 156(7): A4391-. (AMC)

626. Hansen FS, Hoffmans R, Georgalas C, Fokkens WJ. Complications of acute rhinosinusitis in The Netherlands. Family Practice 2012; 29(2): 147-153. (AMC)

627. Harinck F, Kluijt I, van der Stoep N, Oldenburg RA, Wagner A, Aalfs CM, Sijmons RH, Poley J, Kuipers EJ, Fockens P, van Os TAM, Bruno MJ. Indication for CDKN2A-mutation analysis in familial pancreatic cancer families without melanomas. Journal Of Medical Genetics 2012; 49(6): 362-365. (AMC)

628. Harinck F, Kluijt I, van Mil SE, Waisfisz Q, van Os TA, Aalfs CM, Wagner A, Olderode-Berends M, Sijmons RH, Kuipers EJ, Poley JW, Fockens P, Bruno MJ. Routine testing for PALB2 mutations in familial pancreatic cancer families and breast cancer families with pancreatic cancer is not indicated. Eur J Hum Genet 2012; 20: 577-9 (NKI/AMC/VUmc)

629. Harlaar JJ, Gosselink MP, Hop WCJ, Lange JF, Busch ORC, Jeekel H. Blood Transfusions and Prognosis in Colorectal Cancer Long-Term Results of a Randomized Controlled Trial. Annals Of Surgery 2012; 256(5): 681-687. (AMC)

630. Harris SR, Clarke IN, Seth-Smith HMB, Solomon AW, Cutcliffe LT, Marsh P, Skilton RJ, Holland MJ, Mabey D, Peeling RW, Lewis DA, Spratt BG, Unemo M, Persson K, Bjartling C, Brunham R, de Vries HJC, Morre SA, Speksnijder A, Bebear CM, Clerc M, de Barbeyrac B, Parkhill J, Thomson NR. Whole-genome analysis of diverse Chlamydia trachomatis strains identifies phylogenetic relationships masked by current clinical typing. Nature Genetics 2012; 44: 413-U221. (VUmc)

631. Hart A, Baars JW, Brandsma D. Primair centraal zenuwstelsel lymfoom. Foliolum 2012; 25: 7-9 (NKI) 632. Hartog H, Van Der Graaf WT, Boezen HM, Wesseling J. Treatment of breast cancer cells by IGF1R tyrosine kinase

inhibitor combined with conventional systemic drugs. Anticancer Res 2012; 32: 1309-1318 (NKI) 633. Hartsuiker L, Petersen W, Rayavarapu RG, Lenferink A, Poot AA, Terstappen LWMM, van Leeuwen TG, Manohar S, Otto

C. Raman and Fluorescence Spectral Imaging of Live Breast Cancer Cells Incubated with PEGylated Gold Nanorods. Applied Spectroscopy 2012; 66(1): 66-74. (AMC)

634. Hauptmann M, Meulepas JM. CT scans in childhood and risk of leukaemia and brain tumours. Lancet 2012; 380: 1736; author reply 1736-7 (NKI)

635. Hauschild A, Grob JJ, Demidov LV, Jouary T, Gutzmer R, Millward M, Rutkowski P, Blank CU, Miller WH Jr, Kaempgen E, Martín-Algarra S, Karaszewska B, Mauch C, Chiarion- Sileni V, Martin AM, Swann S, Haney P, Mirakhur B, Guckert ME, Goodman V, Chapman PB. Dabrafenib in BRAFmutated metastatic melanoma: a multicentre, open-label, phase 3 randomised controlled trial. Lancet 2012; 380(9839): 358-65 (NKI)

636. Haverkort EB, Binnekade JM, de Haan RJ, Busch ORC, van Berge Henegouwen MI, Gouma DJ. Suboptimal intake of nutrients after esophagectomy with gastric tube reconstruction. Journal Of The Academy Of Nutrition And Dietetics 2012; 112(7): 1080-1087. (AMC)

637. Haverkort MA, van de Kamer JB, Pieters BR, Koning CC, van Herk M, Tiehoven G. Adaptive margin radiotherapy for patients with prostate carcinoma: what’s the benefit? Radiother Oncol 2012; 105: 203-6 (NKI/AMC)

638. Haverman L, Grootenhuis MA, van den Berg JM, van Veenendaal M, Dolman KM, Swart JF, Kuijpers TW, van Rossum MAJ. Predictors of Health-Related Quality of Life in Children and Adolescents With Juvenile Idiopathic Arthritis: Results From a Web-Based Survey. Arthritis Care & Research 2012; 64(5): 694-703. (AMC/VUmc)

639. Haverman L, Verhoof EJ, Maurice-Stam H, Heymans HSA, Gerlag DM, van Rossum MAJ, Grootenhuis MA. Health-related quality of life and psychosocial developmental trajectory in young female beneficiaries with JIA. Rheumatology 2012; 51(2): 368-374. (AMC)

640. Hazenberg CLE, Ossenkoppele GJ, Smit WM. Raynaud-like phenomenon in two patients on nilotinib. British Journal of Haematology 2012; 158: 431. (VUmc)

641. Hazewinkel MH, Gietelink L, van der Velden J, Burger MPM, Stoker J, Roovers JWR. Renal ultrasound to detect hydronephrosis: a need for routine imaging after radical hysterectomy? Gynecologic Oncology 2012; 124(1): 83-86. (AMC)

642. Hazewinkel MH, Sprangers MAG, van der Velden J, Burger MPM, Roovers JWR. Severe pelvic floor symptoms after cervical cancer treatment are predominantly associated with mental and physical well-being and body image: a cross-sectional study. International Journal Of Gynecological Cancer 2012; 22(1): 154-160. (AMC)

643. Hegi ME, Janzer RC, Lambiv WL, Gorlia T, Kouwenhoven MCM, Hartmann C, von Deimling A, Martinet D, Schmutz NB, Diserens AC, Hamou MF, Bady P, Weller M, van den Bent MJ, Mason WP, Mirimanoff RO, Stupp R, Mokhtari K, Wesseling P. Presence of an oligodendroglioma-like component in newly diagnosed glioblastoma identifies a pathogenetically heterogeneous subgroup and lacks prognostic value: central pathology review of the EORTC_26981/NCIC_CE.3 trial. Acta Neuropathologica 2012; 123: 841-852. (VUmc)

644. Hegnauer AM, Hustedt N, Shimada K, Pike BL, Vogel M, Amsler P, Rubin SM, van Leeuwen F, Guenole A, van Attikum H, Thoma NH, Gasser SM. An N-terminal acidic region of Sgs1 interacts with Rpa70 and recruits Rad53 kinase to stalled forks. EMBO J 2012; 31: 3768-83 (NKI)

645. Heidebrecht T, Fish A, von Castelmur E, Johnson KA, Zaccai G, Borst P, Perrakis A. Binding of the J-binding protein to DNA containing glucosylated hmU (base J) or 5-hmC: evidence for a rapid conformational change upon DNA binding. Journal Of The American Chemical Society 2012; 134(32): 13357-13365. (AMC/NKI)

646. Heideman DAM, Lurkin I, Doeleman M, Smit EF, Verheul HM, Meijer GA, Snijders PJF, Thunnissen E, Zwarthoff EC. KRAS and BRAF Mutation Analysis in Routine Molecular Diagnostics: Comparison of Three Testing Methods on Formalin-Fixed, Paraffin-Embedded Tumor-Derived DNA. Journal of Molecular Diagnostics 2012; 14: 247-255. (VUmc/NKI)

647. Heijblom M, Piras D, Xia W, van Hespen JCG, Klaase JM, van den Engh FM, van Leeuwen TG, Steenbergen W, Manohar S. Visualizing breast cancer using the Twente photoacoustic mammoscope: what do we learn from twelve new patient measurements? Optics Express 2012; 20(11): 11582-11597. (AMC)

648. Heijmans J, Büller NV, Muncan V, van den Brink GR. Role of mast cells in colorectal cancer development, the jury is still out. Biochimica Et Biophysica Acta-Molecular Basis Of Disease 2012; 1822(1): 9-13. (AMC)


649. Heijmans J, Büller NVJA, Muncan V, van den Brink GR. Rage mediated DAMP signaling in intestinal tumorigenesis. Oncoimmunology 2012; 1(7): 1165-1166. (AMC)

650. Heijmen L, de Geus-Oei LF, de Wilt JHW, Visvikis D, Hatt M, Visser EP, Bussink J, Punt CJA, Oyen WJG, van Laarhoven HWM. Reproducibility of functional volume and activity concentration in (18)F-FDG PET/CT of liver metastases in colorectal cancer. European Journal Of Nuclear Medicine And Molecular Imaging 2012; 39(12): 1858-1867. (AMC)

651. Heijmen L, Fütterer JJ, van Laarhoven HWM. Intra-thoracic mass on CT in a breast cancer patient. Netherlands Journal Of Medicine 2012; 70(6): 283-286. (AMC)

652. Heijmen L, van Dijk EJ, Goraj B, van Laarhoven HWM. Moyamoya Disease Misdiagnosed As Leptomeningeal Metastases. Journal Of Clinical Oncology 2012; 30(36): E382-E385. (AMC)

653. Heijmen L, van Laarhoven HWM, Punt CJA, van den Hurk D, van der Drift MA, Ottevanger PB, Timmer-Bonte JNH. Encouraging results in older patients receiving chemotherapy: a retrospective analysis of treatment guideline adherence in daily practice. Geriatrics & Gerontology International 2012; 12(1): 80-85. (AMC)

654. Heijmen L, Verstappen MCHM, ter Voert EEGW, Punt CJA, Oyen WJG, de Geus-Oei LF, Hermans JJ, Heerschap A, van Laarhoven HWM. Tumour response prediction by diffusion-weighted MR imaging: Ready for clinical use? Critical Reviews In Oncology Hematology 2012; 83(2): 194-207. (AMC)

655. Heijnsdijk EA, Warner E, Gilbert FJ, Tilanus-Linthorst MM, Evans G, Causer PA, Eeles RA, Kaas R, Draisma G, Ramsay EA, Warren RM, Hill KA, Hoogerbrugge N, Wasser MN, Bergers E, Oosterwijk JC, Hooning MJ, Rutgers EJT, Klijn JG, Plewes DB, Leach MO, de Koning HJ. Differences in natural history between breast cancers in BRCA1 and BRCA2 mutation carriers and effects of MRI screening-MRISC, MARIBS, and Canadian studies combined. Cancer Epidemiol Biomarkers Prev 2012; 21: 1458-68 (NKI/VUmc)

656. Heimans JJ, Reijneveld JC. Factors affecting the cerebral network in brain tumor patients. Journal of Neuro-Oncology 2012; 108: 231-237. (VUmc)

657. Hein R, Maranian M, Hopper JL, Kapuscinski MK et al. Comparison of 6q25 Breast Cancer Hits from Asian and European Genome Wide Association Studies in the Breast Cancer Association Consortium (BCAC). PLoS One 2012; 7: e42380 (NKI)

658. Helbig C, Gentek R, Backer RA, de Souza Y, Derks IAM, Eldering E, Wagner K, Jankovic D, Gridley T, Moerland PD, Flavell RA, Amsen D. Notch controls the magnitude of T helper cell responses by promoting cellular longevity. Proceedings Of The National Academy Of Sciences Of The United States Of America 2012; 109(23): 9041-9046. (AMC)

659. Hendricksen K, Cornel EB, de Reijke TM, Arentsen HC, Chawla S, Witjes JA. Phase 2 study of adjuvant intravesical instillations of apaziquone for high risk nonmuscle invasive bladder cancer. Journal Of Urology 2012; 187(4): 195-1199. (AMC)

660. Hendriks MP, van Laarhoven HWM, van de Sande R, van Weel-Baumgarten E, Verhagen CA, Vissers KC. Palliative care for an Islamic patient: changing frameworks. Journal Of Palliative Medicine 2012; 15(10): 1053-1055. (AMC)

661. Henken FE, De-Castro Arce J, Rosl F, Bosch L, Meijer CJLM, Snijders PJF, Steenbergen RDM. The functional role of Notch signaling in HPV-mediated transformation is dose-dependent and linked to AP-1 alterations. Cell Oncol 2012; 35: 77-84. (VUmc)

662. Henken FE, Oosterhuis K, Ohlschlager P, Bosch L, Hooijberg E, Haanen JBAG, Steenbergen RDM. Preclinical safety evaluation of DNA vaccines encoding modified HPV16 E6 and E7. Vaccine 2012; 30: 4259-4266. (VUmc/NKI)

663. Henselmans I, Douma KF, van woerden D, Hillen MA. De kankerpatiënt anno 2012: Geïnformeerd, besluitvaardig, mondig en kritisch? Psycholoog 2012; 47(6): 42-52. (AMC)

664. Henselmans I, Jacobs M, van Berge Henegouwen MI, de Haes HCJM, Sprangers MAG, Smets EMA. Postoperative information needs and communication barriers of esophageal cancer patients. Patient Education And Counseling 2012; 88(1): 138-146. (AMC)

665. Hensen EF, van Duinen N, Jansen JC, Corssmit EPM, Tops CMJ, Romijn JA, Vriendsd AHJT, van der Mey AGL, Cornelisse CJ, Devilee P, Bayley JP. High prevalence of founder mutations of the succinate dehydrogenase genes in the Netherlands. Clinical Genetics 2012; 81: 284-288. (VUmc)

666. Hermsen IGC, Kerkhofs TMA, den Butter G, Kievit J, van Eijck CHJ, Nieveen van Dijkum EJM, Haak HR. Surgery in adrenocortical carcinoma: Importance of national cooperation and centralized surgery. Surgery 2012; 152(1): 50-56. (AMC)

667. Hertog D, Bloemena E, Aartman IHA, van der Waal I. Histopathology of ameloblastoma of the jaws; some critical observations based on a 40 years single institution experience. Medicina Oral, Patologia Oral y Cirugia Bucal 2012; 17: e76-e82. (VUmc)

668. Heskamp S, Laverman P, Rosik D, Boschetti F, van der Graaf WTA, Oyen WJG, van Laarhoven HWM, Tolmachev V, Boerman OC. Imaging of human epidermal growth factor receptor type 2 expression with 18F-labeled affibody molecule ZHER2:2395 in a mouse model for ovarian cancer. Journal Of Nuclear Medicine 2012; 53(1): 146-153. (AMC)

669. Heskamp S, van Laarhoven HWM, Molkenboer-Kuenen JDM, Bouwman WH, van der Graaf WTA, Oyen WJG, Boerman OC. Optimization of IGF-1R SPECT/CT Imaging Using (111)In-Labeled F(ab')(2) and Fab Fragments of the Monoclonal Antibody R1507. Molecular Pharmaceutics 2012; 9(8): 2314-2321. (AMC)

670. Hess DLJ, Pettersson Fernholm AM, Rijnsburger MC, Herbrink P, van den Berg HP, Ang CW. Gastroenteritis caused by Campylobacter concisus. Journal of Medical Microbiology 2012; 61: 746-749. (VUmc)

671. Heutinck KM, Rowshani AT, Kassies J, Claessen N, van Donselaar-van der Pant KAMI, Bemelman FJ, Eldering E, van Lier RAW, Florquin S, ten Berge IJM, Hamann J. Viral double-stranded RNA sensors induce antiviral, pro-inflammatory, and pro-apoptotic responses in human renal tubular epithelial cells. Kidney International 2012; 82(6): 664-675. (AMC)

672. Heuveling DA, Flach GB, van Schie A, van Weert S, Karagozoglu KH, Bloemena E, Leemans CR, de Bree R. Visualization of the sentinel node in early-stage oral cancer: limited value of late static lymphoscintigraphy. Nuclear Medicine Communications 2012; 33: 1065-1069. (VUmc)

673. Heuveling DA, Karagozoglu KH, van Schie A, van Weert S, van Lingen A, de Bree R. Sentinel node biopsy using 3D lymphatic mapping by freehand SPECT in early stage oral cancer: a new technique. Clinical Otolaryngology 2012; 37: 89-90. (VUmc)

674. Heuveling DA, Visser GWM, de Groot M, de Boer JF, Baclayon M, Roos WH, Wuite GJL, Leemans CR, de Bree R, van Dongen GAMS. Nanocolloidal albumin-IRDye 800CW: a near-infrared fluorescent tracer with optimal retention in the sentinel lymph node. European Journal of Nuclear Medicine and Molecular Imaging 2012; 39: 1161-1168. (VUmc)

675. Hew MN, Zonneveld R, Kummerlin IP, Opondo D, de la Rosette JJ, Laguna M. Age and Gender Related Differences in Renal Cell Carcinoma in a European Cohort. Journal of Urology 2012; 188: 33-38. (VUmc/AMC)


676. Hibbert RG, Sixma TK. Intrinsic Flexibility of Ubiquitin on Proliferating Cell Nuclear Antigen (PCNA) in Translesion Synthesis. J Biol Chem 2012; 287: 39216-23 (NKI)

677. Hiemstra IH, Bouma G, Geerts D, Kraal G, den Haan JMM. Nod2 improves barrier function of intestinal epithelial cells via enhancement of TLR responses. Molecular Immunology 2012; 52: 264-272. (VUmc)

678. Hilarius DL, Kloeg PH, van der Wall E, van den Heuvel JJG, Gundy CM, Aaronson NK. Chemotherapy-induced nausea and vomiting in daily clinical practice: A community hospitalbased study. J Support Care Cancer 2012; 20: 107-117 (NKI)

679. Hilbers FS, Boekel NB, van den Broek AJ, van Hien R, Cornelissen S, Aleman BM, van ‘t Veer LJ, van Leeuwen FE, Schmidt MK. Genetic variants in TGFβ-1 and PAI-1 as possible risk factors for cardiovascular disease after radiotherapy for breast cancer. Radiother Oncol 2012; 102: 115-21 (NKI)

680. Hilgers FJM, Dirven R, Wouters Y, Jacobi I, Marres HAM, van den Brekel MWM. A multicenter prospective clinical trial evaluating a novel adhesive baseplate (Provox StabiliBase) for enhanced peristomal attachment of postlaryngectomy pulmonary and voice rehabilitation devices. Laryngoscope 2012; 122: 2447-53 (NKI)

681. Hill SM, Lu Y, Molina J, Heiser LM, Spellman PT, Speed TP, Gray JW, Mills GB, Mukherjee S. Bayesian Inference of Signaling Network Topology in a Cancer Cell Line. Bioinformatics 2012; 28: 2804-10 (NKI)

682. Hill SM, Neve RM, Bayani N, Kuo W-L, Ziyad S, Spellman PT, Gray JW, Mukherjee S. Integrating biological knowledge into variable selection: an empirical Bayes approach with an application in cancer biology. BMC Bioinformatics 2012; 13: 94 (NKI)

683. Hillen MA, Koning CCE, Wilmink JW, Klinkenbijl JHG, Eddes EH, Kallimanis-King BL, de Haes JCJM, Smets EMA. Assessing cancer patients' trust in their oncologist: development and validation of the Trust in Oncologist Scale (TiOS). Supportive Care In Cancer 2012; 20(8): 1787-1795. (AMC)

684. Hillen MA, Onderwater AT, van Zwieten MCB, de Haes HCJM, Smets EMA. Disentangling cancer patients' trust in their oncologist: a qualitative study. Psycho-Oncology 2012; 21(4): 392-399. (AMC)

685. Hindriksen S, Bijlsma MF. Cancer Stem Cells, EMT, and Developmental Pathway Activation in Pancreatic Tumors. Cancers 2012; 4(4) 989-1035. (AMC)

686. Hirdes MMC, van Hooft JE, Wijrdeman HK, Hulshof MCCM, Fockens P, Reerink O, van Oijen MGH, van der Tweel I, Vleggaar FP, Siersema PD. Combination of biodegradable stent placement and single-dose brachytherapy is associated with an unacceptably high complication rate in the treatment of dysphagia from esophageal cancer. Gastrointestinal Endoscopy 2012; 76(2): 267-274. (AMC)

687. Hjermstad MJ, Bergenmar M, Fisher SE, Montel S, Nicolatou-Galitis O, Raber-Durlacher J, Singer S, Verdonck-de Leeuw I, Weis J, Yarom N, Herlofson BB. The EORTC QLQ-OH17: A supplementary module to the EORTC QLQ-C30 for assessment of oral health and quality of life in cancer patients. European Journal of Cancer 2012; 48: 2203-2211. (VUmc)

688. Ho YS, Adroub SA, Abadi M, Al Alwan B, Alkhateeb R, Gao G, Ragab A, Ali S, van Soolingen D, Bitter W, Pain A, Abdallah AM. Complete Genome Sequence of Mycobacterium vaccae Type Strain ATCC 25954. Journal of Bacteriology 2012; 194: 6339-6340. (VUmc)

689. Ho YS, Adroub SA, Aleisa F, Mahmood H, Othoum G, Rashid F, Zaher M, Ali S, Bitter W, Pain A, Abdallah AM. Complete Genome Sequence of Mycobacterium fortuitum subsp fortuitum Type Strain DSM46621. Journal of Bacteriology 2012; 194: 6337-6338. (VUmc)

690. Hoebe EK, Le Large TYS, Tarbouriech N, Oosterhoff D, de Gruijl TD, Middeldorp JM, Greijer AE. Epstein-Barr Virus-Encoded BARF1 Protein is a Decoy Receptor for Macrophage Colony Stimulating Factor and Interferes with Macrophage Differentiation and Activation. Viral Immunology 2012; 25: 461-470. (VUmc)

691. Hoebe EK, Wille C, Hopmans ES, Robinson AR, Middeldorp JM, Kenney SC, Greijer AE. Epstein-Barr Virus Transcription Activator R Upregulates BARF1 Expression by Direct Binding to Its Promoter, Independent of Methylation. Journal of Virology 2012; 86: 11322-11332. (VUmc)

692. Hoefnagel LD, Moelans CB, Meijer SL, van Slooten HJ, Wesseling P, Wesseling J, Westenend PJ, Bart J, Seldenrijk CA, Nagtegaal ID, Oudejans J, van der Valk P, van Gils CH, van der Wall E, van Diest PJ. Prognostic value of estrogen receptor α and progesterone receptor conversion in distant breast cancer metastases. Cancer 2012; 118: 4929-4935 (NKI/VUmc)

693. Hoefsloot W, Boeree MJ, van Nieuwkoop C, Bernards AT, Savelkoul PHM, van Ingen J, van Soolingen D. No human transmission of Mycobacterium malmoense in a perfect storm setting. European Respiratory Journal 2012; 40: 1576-1578. (VUmc)

694. Hoekstra HJ. Gerandomizeerd onderzoek verschaft meer duidelijkheid over sentinelnodebiopsie bij melanoom. Ned Tijdschr Oncol 2012; 3: 131-134. (NKI)

695. Hoekstra LT, Busch ORC, Bemelman WA, van Gulik TM, Tanis PJ. Initial experiences of simultaneous laparoscopic resection of colorectal cancer and liver metastases. HPB Surgery 2012; 2012: 893956-. (AMC)

696. Hoekstra LT, van Gulik TM, Gouma DJ, Busch OR. Posthepatectomy bile leakage: how to manage. Digestive Surgery 2012; 29(1): 48-53. (AMC)

697. Hoekstra LT, van Lienden KP, Doets A, Busch ORC, Gouma DJ, van Gulik TM. Tumor progression after preoperative portal vein embolization. Annals Of Surgery 2012; 256(5): 812-7; discussion 817-8. (AMC)

698. Hoekstra LT, van Lienden KP, Schaap FG, Chamuleau RAFM, Bennink RJ, van Gulik TM. Can plasma bile salt, triglycerides, and apoA-V levels predict liver regeneration? World Journal Of Surgery 2012; 36(12): 2901-2908. (AMC)

699. Hoekstra LT, van Trigt JD, Reiniers MJ, Busch OR, Gouma DJ, van Gulik TM. Vascular occlusion or not during liver resection: the continuing story. Digestive Surgery 2012; 29(1): 35-42. (AMC)

700. Hoekstra LT, Wakkie T, Busch ORC, Gouma DJ, Beuers U, van Gulik T. Predictors of Posthepatectomy Ascites with or without Previous Portal Vein Embolization. Digestive Surgery 2012; 29(6): 468-474. (AMC)

701. Hoekstra ME, van Beek AE, Gomez- Eerland R, Ritsma L, van Rheenen J, Marée AF, Zal T, de Boer RJ, Haanen JB, Schumacher TN. Tissue-resident memory CD8+ T cells continuously patrol skin epithelia to quickly recognize local antigen. Proc Natl Acad Sci USA 2012; 109: 19739-44 (NKI)

702. Hoentjen F, Hanauer SB, de Boer NK, Rubin DT. Two Brothers with Skewed Thiopurine Metabolism in Ulcerative Colitis Treated Successfully with Allopurinol and Mercaptopurine Dose Reduction. Digestive Diseases and Sciences 2012; 57: 250-253. (VUmc)

703. Hoentjen F, Rubin DT. Infectious Proctitis: When to Suspect It Is Not Inflammatory Bowel Disease. Digestive Diseases and Sciences 2012; 57: 269-273. (VUmc)


704. Hoffmann V, Baccarani M, Hasford J, Guilhot J, Saussele S, Rosti G, Guilhot F, Porkka K, Ossenkoppele G, Lindoerfer D, Simonsson B, Pfirrmann M, Hehlmann R. The EUTOS CML score aims to support clinical decision-making. Blood 2012; 119: 2966-2967. (VUmc)

705. Hofstee HMA, Serne EH, Roberts C, Hesselstrand R, Scheja A, Moore TL, Wildt M, Manning JB, Noordegraaf AV, Voskuyl AE, Herrick AL. A multicentre study on the reliability of qualitative and quantitative nail-fold videocapillaroscopy assessment. Rheumatology 2012; 51: 749-755. (VUmc)

706. Hofstee HMA, Serne EH, Roberts C, Hesselstrand R, Scheja A, Moore TL, Wildt M, Manning JB, Noordegraaf AV, Voskuyl AE, Herrick AL. Comment on: A multicentre study on the reliability of qualitative and quantitative nailfold videocapillaroscopy assessment: reply. Rheumatology 2012; 51: 1922. (VUmc)

707. Hofstee HMA, Voskuyl AE, Noordegraaf AV, Smulders YM, Postmus PE, Dijkmans BAC, Serne EH. Pulmonary Arterial Hypertension in Systemic Sclerosis Is Associated with Profound Impairment of Microvascular Endothelium-dependent Vasodilatation. Journal of Rheumatology 2012; 39: 100-105. (VUmc)

708. Hogenbirk MA, Velds A, Kerkhoven RM, Jacobs H. Reassessing genomic targeting of the activation induced cytidine deaminase. Nat Immunol 2012; 13: 797-8 (NKI)

709. Hogg-Kollars S, Rostami-Nejad M, Rostami K. Where are We Standing with the Screening of Healthy Population for Celiac Disease?. Archives of Iranian Medicine 2012; 15: 338-339. (VUmc)

710. Hohenester S, Wenniger LMD, Paulusma CC, van Vliet SJ, Jefferson DM, Elferink RPO, Beuers U. A biliary HCO3- umbrella constitutes a protective mechanism against bile acid-induced injury in human cholangiocytes. Hepatology 2012; 55: 173-183. (VUmc)

711. Hol L, Kuipers EJ, van Ballegooijen M, van Vuuren AJ, Reijerink JC, Habbema DJ, van Leerdam ME. Uptake of faecal immunochemical test screening among nonparticipants in a flexible sigmoidoscopy screening programme. Int J Cancer 2012; 130: 2096-102 (NKI)

712. Holla JFM, van der Leeden M, Knol DL, Peter WFH, Roorda LD, Lems WF, Wesseling J, Steultjens MPM, Dekker J. Avoidance of Activities in Early Symptomatic Knee Osteoarthritis: Results from the CHECK Cohort. Annals of Behavioral Medicine 2012; 44: 33-42. (VUmc)

713. Holla JFM, van der Leeden M, Peter WFH, Roorda LD, van der Esch M, Lems WF, Gerritsen M, Voorneman RE, Steultjens MPM, Dekker J. Proprioception, Laxity, Muscle Strength and Activity Limitations in Early Symptomatic Knee Osteoarthritis: Results from the Check Cohort. Journal of Rehabilitation Medicine 2012; 44: 862-868. (VUmc)

714. Holla JFM, van der Leeden M, Roorda LD, Bierma-Zeinstra SMA, Damen J, Dekker J, Steultjens MPM. Diagnostic accuracy of range of motion measurements in early symptomatic hip and/or knee osteoarthritis. Arthritis Care & Research 2012; 64: 59-65. (VUmc)

715. Hollak CEM, de Sonnaville ESV, Cassiman D, Linthorst GE, Groener JE, Morava E, Wevers RA, Mannens M, Aerts JMFG, Meersseman W, Akkerman E, Niezen-Koning KE, Mulder MF, Visser G, Wijburg A, Lefeber D, Poorthuis BJHM. Acid sphingomyelinase (Asm) deficiency patients in The Netherlands and Belgium: Disease spectrum and natural course in attenuated patients. Molecular Genetics and Metabolism 2012; 107: 526-533. (VUmc)

716. Hollevoet K, Reitsma JB, Creaney J, Grigoriu BD, Robinson BW, Scherpereel A, Cristaudo A, Pass HI, Nackaerts K, Rodríguez Portal JA, Schneider J, Muley T, Di Serio F, Baas P, Tomasetti M, Rai AJ, van Meerbeeck JP. Serum mesothelin for diagnosing malignant pleural mesothelioma: an individual patient data meta-analysis. J Clin Oncol 2012; 30: 1541-9 (NKI)

717. Holz LE, Benseler V, Vo M, McGuffog C, Van Rooijen N, McCaughan GW, Bowen DG, Bertolino P. Naive CD8 T cell activation by liver bone marrow-derived cells leads to a "neglected" IL-2(low) Bim(high) phenotype, poor CTL function and cell death. Journal of Hepatology 2012; 57: 830-836. (VUmc)

718. Holzner B, Efficace F, Basso U, Incrocci L, Johnson C, Aaronson N, Arraras J, King M, Chow E, Oberguggenberger A, Bottomley A, Steiner H, Giesinger J. Cross-cultural development of an EORTC questionnaire to assess health-related quality of life in patients with testicular cancer: The EORTC TC26. Qual Life Res, 2012 (NKI)

719. Hooijkaas A, Gadiot J, Morrow M, Stewart R, Schumacher T, Blank CU. Selective BRAF inhibition decreases tumor-resident lymphocyte frequencies in a mouse model of human melanoma. Oncoimmunology 2012; 1: 609-17 (NKI)

720. Hooijkaas AI, Gadiot J, van der Valk M, Mooi WJ, Blank CU. Targeting BRAF(V600E) in an inducible murine model of melanoma. Am J Pathol 2012; 181: 785-94 (NKI/VUmc)

721. Hoornweg MJ, Smeulders MJ, Ubbink DT, van der Horst CM. The prevalence and risk factors of infantile hemangiomas: A case-control study in the Dutch population. Paediatr Perinat Epidemiol 2012; 26: 156-62 (NKI)

722. Hoorweg K, Peters CP, Cornelissen F, Aparicio-Domingo P, Papazian N, Kazemier G, Mjösberg JM, Spits H, Cupedo T. Functional Differences between Human NKp44(-) and NKp44(+) RORC(+) Innate Lymphoid Cells. Frontiers In Immunology 2012; 3: 72-. (AMC)

723. Hopker K, Hagmann H, Khurshid S, Chen S, Hasskamp P, Seeger- Nukpezah T, Schilberg K, Heukamp L, Lamkemeyer T, Sos ML, Thomas RK, Lowery D, Roels F, Fischer M, Liebau MC, Resch U, Kisner T, Rother F, Bartram MP, Muller RU, Fabretti F, Kurschat P, Schumacher B, Gaestel M, Medema RH, Yaffe MB, Schermer B, Reinhardt HC, Benzing T. AATF/ Che-1 acts as a phosphorylationdependent molecular modulator to repress p53-driven apoptosis. EMBO J 2012; 31: 3961-75 (NKI)

724. Hopman SMJ, van Rijn RR, Eng C, Bras J, Alders M, van der Horst CM, Hennekam RCM, Merks JHM. PTEN hamartoma tumor syndrome and Gorham-Stout phenomenon. American Journal Of Medical Genetics Part A 2012; 158AA(7): 1719-1723. (AMC)

725. Horenblas S. Sentinel lymph node biopsy in penile carcinoma. Seminars in diagnostic pathology 2012; 29: 90-5 (NKI) 726. Houben D, Demangel C, van Ingen J, Perez J, Baldeon L, Abdallah AM, Caleechurn L, Bottai D, van Zon M, de Punder

K, van der Laan T, Kant A, Bossers-de Vries R, Willemsen P, Bitter W, van Soolingen D, Brosch R, van der Wel N, Peters PJ. ESX-1-mediated translocation to the cytosol controls virulence of mycobacteria. Cellular Microbiology 2012; 14: 1287-1298. (VUmc/NKI)

727. Houben ENG, Bestebroer J, Ummels R, Wilson L, Piersma SR, Jimenez CR, Ottenhoff THM, Luirink J, Bitter W. Composition of the type VII secretion system membrane complex. Molecular Microbiology 2012; 86: 472-484. (VUmc)

728. Houtman R, de Leeuw R, Rondaij M, Melchers D, Verwoerd D, Ruijtenbeek R, Martens JW, Neefjes J, Michalides R. Serine-305 phosphorylation modulates estrogen receptor alpha binding to a coregulator peptide array, with potential application in predicting responses to tamoxifen. Mol Cancer Ther 2012; 11: 805-16 (NKI)

729. Hoving S, Heeneman S, Gijbels MJ, Te Poele JA, Visser N, Cleutjens J, Russell NS, Daemen MJ, Stewart FA. Irradiation induces different inflammatory and thrombotic responses in carotid arteries of wildtype C57BL/6J and atherosclerosis-prone ApoE(-/-) mice. Radiother Oncol 2012; 105: 365-70 (NKI)


730. Howard JH, Thompson JF, Mozzillo N, Nieweg OE, Hoekstra HJ, Roses DF, Sondak VK, Reintgen DS, Kashani- Sabet M, Karakousis CP, Coventry BJ, Kraybill WG, Smithers BM, Elashoff R, Stern SL, Cochran AJ, Faries MB, Morton DL. Metastasectomy for distant metastatic melanoma: analysis of data from the first Multicenter Selective Lymphadenectomy Trial (MSLT-I). Ann Surg Oncol 2012; 19: 2547-2555 (NKI)

731. Huang K, Dahele M, Senan S, Guckenberger M, Rodrigues GB, Ward A, Boldt RG, Palma DA. Radiographic changes after lung stereotactic ablative radiotherapy (SABR) - Can we distinguish recurrence from fibrosis? A systematic review of the literature. Radiotherapy and Oncology 2012; 102: 335-342. (VUmc)

732. Huang S, Holzel M, Knijnenburg T, Schlicker A, Roepman P, McDermott U, Garnett M, Grernrum W, Sun C, Prahallad A, Groenendijk FH, Mittempergher L, Nijkamp W, Neefjes J, Salazar R, Ten Dijke P, Uramoto H, Tanaka F, Beijersbergen RL, Wessels LF, Bernards R. MED12 Controls the Response to Multiple Cancer Drugs through Regulation of TGF-beta Receptor Signalling. Cell 2012; 151: 937-50 (NKI)

733. Hubers AJ, Heideman DA, Herder GJ, Burgers SA, Sterk PJ, Kunst PW, Smit HJ, Postmus PE, Witte BI, Duin S, Snijders PJ, Smit EF, Thunnissen E. Prolonged sampling of spontaneous sputum improves sensitivity of hypermethylation analysis for lung cancer. J Clin Pathol 2012; 65: 541-5 (NKI/AMC/VUmc)

734. Hui KF, Ho DN, Tsang CM, Middeldorp JM, Tsao GSW, Chiang AKS. Activation of lytic cycle of Epstein-Barr virus by suberoylanilide hydroxamic acid leads to apoptosis and tumor growth suppression of nasopharyngeal carcinoma. International Journal of Cancer 2012; 131: 1930-1940. (VUmc)

735. Huijsmans CJJ, Poodt J, Damen J, van der Linden JC, Savelkoul PHM, Pruijt JFM, Hilbink M, Hermans MHA. Single Nucleotide Polymorphism (SNP)-Based Loss of Heterozygosity (LOH) Testing by Real Time PCR in Patients Suspect of Myeloproliferative Disease. PloS one 2012; 7: . (VUmc)

736. Huisman EJ, van Hoek B, van Soest H, van Nieuwkerk KM, Arends JE, Siersema PD, van Erpecum KJ. Preventive versus "on-demand" nutritional support during antiviral treatment for hepatitis C: A randomized controlled trial. Journal of Hepatology 2012; 57: 1069-1075. (VUmc)

737. Huizinga R, van der Star BJ, Kipp M, Jong R, Gerritsen W, Clarner T, Puentes F, Dijkstra CD, van der Valk P, Amor S. Phagocytosis of neuronal debris by microglia is associated with neuronal damage in multiple sclerosis. Glia 2012; 60: 422-431. (VUmc)

738. Hulshof M, Bel A. Automatic bladder segmentation on CBCT for multiple plan ART of bladder cancer using a patientspecific bladder model. Phys Med Biol 2012; 57: 3945-62 (NKI)

739. Hunfeld NG, Touw DJ, Mathot RA, van Schaik RH, Kuipers EJ. A comparison of the acid-inhibitory effects of esomeprazole and rabeprazole in relation to pharmacokinetics and CYP2C19 polymorphism. Alimentary Pharmacology & Therapeutics 2012; 35(7): 810-818. (AMC)

740. Hunfeld NGM, Touw DJ, Mathot RAA, Mulder PGH, van Schaik RHN, Kuipers EJ, Kooiman JC, Geus WP. Vergelijking van de zuurremmende effecten van esomeprazol en pantoprazol in relatie tot farmacokinetiek en CYP2C19-polymorfisme. Pharmaceutisch Weekblad 2012; 147(50): 198-202. (AMC)

741. Hurkmans CW, Dijckmans I, Reijnen M, van der Leer J, van Vliet-Vroegindeweij C, van der Sangen M. Adaptive radiation therapy for breast IMRTsimultaneously integrated boost: threeyear clinical experience. Radiother Oncol 2012; 103: 183-7 (NKI)

742. Hurkmans CW, Knegjens JL, Oei BS, Maas AJ, Uiterwaal G, van der Borden AJ, Ploegmakers MM, van Erven L. Management of radiation oncology patients with a pacemaker or ICD: a new comprehensive practical guideline in the Netherlands. Radiat Oncol 2012; 7: 198 (NKI)

743. Hutajulu SH, Ng N, Jati BR, Fachiroh J, Herdini C, Hariwiyanto B, Haryana SM, Middeldorp JM. Seroreactivity against Epstein-Barr virus (EBV) among first-degree relatives of sporadic EBV-associated nasopharyngeal carcinoma in Indonesia. Journal of Medical Virology 2012; 84: 768-776. (VUmc)

744. Idema AJS, Hoffmann AL, Boogaarts HD, Troost EGC, Wesseling P, Heerschap A, van der Graaf WTA, Grotenhuis JA, Oyen WJG. 3 '-Deoxy-3 '-F-18-Fluorothymidine PET-Derived Proliferative Volume Predicts Overall Survival in High-Grade Glioma Patients. Journal of Nuclear Medicine 2012; 53: 1904-1910. (VUmc)

745. Immink JM, Putter H, Bartelink H, Cardoso JS, Cardoso MJ, van der Hulst-Vijgen MH, Noordijk EM, Poortmans PM, Rodenhuis CC, Struikmans H. Long-term cosmetic changes after breast-conserving treatment of patients with stage I-II breast cancer and included in the EORTC ‘boost versus no boost’ trial. Ann Oncol 2012; 23: 2591-8 (NKI)

746. Ince C, van Kuijen A, Milstein DMJ, Yürük K, Folkow LP, Fokkens WJ, Blix AS. Why Rudolph's nose is red: observational study. British Medical Journal 2012; 345: e8311-. (AMC)

747. Indrasari SR, Timmermans AJ, Wildeman MA, Karakullukcu MB, Herdini C, Hariwiyanto B, Tan IB. Remarkable response to photodynamic therapy in residual T4N0M0 nasopharyngeal carcinoma: A case report. Photodiagnosis Photodyn Ther 2012; 9: 319-20 (NKI)

748. Ingersoll MA, Potteaux S, Alvarez D, Hutchison SB, Van Rooijen N, Randolph GJ. Niacin inhibits skin dendritic cell mobilization in a GPR109A independent manner but has no impact on monocyte trafficking in atherosclerosis. Immunobiology 2012; 217: 548-557. (VUmc)

749. Israëls J, Scherpbier HJ, Frakking FNJ, van de Wetering MD, Kremer LCM, Kuijpers TW. Mannose-binding lectin and the risk of HIV transmission and disease progression in children: a systematic review. Pediatric Infectious Disease Journal 2012; 31(12): 1272-1278. (AMC)

750. Israels T, Borgstein E, Pidini D, Chagaluka G, de Kraker J, Kamiza S, Molyneux EM. Management of children with a Wilms tumor in Malawi, sub-Saharan Africa. Journal Of Pediatric Hematology Oncology 2012; 34(8): 606-610. (AMC/VUmc)

751. Israels T, Borgstein E, Pidini D, de Kraker J, Kamiza S, Molyneux E. The Efficacy and Toxicity of Siop Preoperative Chemotherapy in Malawian Children with A Wilms Tumour. Pediatric Blood & Cancer 2012; 59: 636-641. (VUmc)

752. Israels T, Chagaluka G, Pidini D, Caron H, de Kraker J, Kamiza S, Borgstein E, Molyneux L. The efficacy and toxicity of SIOP preoperative chemotherapy in Malawian children with a Wilms tumour. Pediatric Blood & Cancer 2012; 59(4): 636-641. (AMC)

753. Israels T. Wilms tumor in Africa: challenges to cure. Pediatric Blood & Cancer 2012; 58(1): 3-4. (AMC/Vumc) 754. Iusuf D, Sparidans RW, van Esch A, Hobbs M, Kenworthy K, van de Steeg E, Wagenaar E, Beijnen JH, Schinkel AH.

Organic anion-transporting polypeptides 1a/1b control the hepatic uptake of pravastatin in mice. Mol Pharm 2012; 9: 2497-504 (NKI)

755. Iusuf D, van de Steeg E, Schinkel AH. Functions of OATP1A and 1B transporters in vivo: insights from mouse models. Trends Pharmacol Sci 2012; 33: 100-8 (NKI)


756. Iusuf D, van de Steeg E, Schinkel AH. Hepatocyte hopping of OATP1B substrates contributes to efficient hepatic detoxification. Clin Pharmacol Ther 2012; 92: 559-62 (NKI)

757. Jacobs JJL. Fusing telomeres with RNF8. Nucleus 2012; 3: 143-149 (NKI) 758. Jager NG, Rosing H, Linn SC, Schellens JH, Beijnen JH. Importance of highly selective LC-MS/MS analysis for the

accurate quantification of tamoxifen and its metabolites: focus on endoxifen and 4-hydroxytamoxifen. Breast Cancer Res Treat 2012; 133: 793-8 (NKI)

759. Jakob F, Oertel H, Langdahl B, Ljunggren O, Barrett A, Karras D, Walsh JB, Fahrleitner-Pammer A, Rajzbaum G, Barker C, Lems WF, Marin F. Effects of teriparatide in postmenopausal women with osteoporosis pre-treated with bisphosphonates: 36-month results from the European Forsteo Observational Study. European Journal of Endocrinology 2012; 166: 87-97. (VUmc)

760. Jakubowska A, Rozkrut D, Antoniou A, Hamann U, Scott RJ, McGuffog L, Healy S, Sinilnikova OM, Rennert G, Lejbkowicz F, Flugelman A, Andrulis IL, Glendon G, Ozcelik H; OCGN, Thomassen M, Paligo M, Aretini P; SWE-BRCA, Kantala J, Aroer B, von Wachenfeldt A, Liljegren A, Loman N, Herbst K, Kristoffersson U, Rosenquist R, Karlsson P, Stenmark- Askmalm M, Melin B, Nathanson KL, Domchek SM, Byrski T, Huzarski T, Gronwald J, Menkiszak J, Cybulski C, Serrano P, Osorio A, Cajal TR, Tsitlaidou M, Benítez J, Gilbert M; HEBON, Rookus M, Aalfs CM, Kluijt I, Boessenkool-Pape JL, Meijers-Heijboer HE, Oosterwijk JC, van Asperen CJ, Blok MJ, Nelen MR, van den Ouweland AM, Seynaeve C, van der Luijt RB, Devilee P; EMBRACE, Easton DF, Peock S, Frost D, Platte R, Ellis SD, Fineberg E, Evans DG, Lalloo F, Eeles R, Jacobs C, Adlard J, Davidson R, Eccles D, Cole T, Cook J, Godwin A, Bove B; GEMO Study Collaborators, Stoppa-Lyonnet D, Caux-Moncoutier V, Belotti M, Tirapo C, Mazoyer S, Barjhoux L, Boutry-Kryza N, Pujol P, Coupier I, Peyrat JP, Vennin P, Muller D, Fricker JP, Venat-Bouvet L, Johannsson OT, Isaacs C, Schmutzler R, Wappenschmidt B, Meindl A, Arnold N, Varon-Mateeva R, Niederacher D, Sutter C, Deissler H, Preisler-Adams S, Simard J, Soucy P, Durocher F, Chenevix-Trench G, Beesley J, Chen X; KConFab, Rebbeck T, Couch F, Wang X, Lindor N, Fredericksen Z, Pankratz VS, Peterlongo P, Bonanni B, Fortuzzi S, Peissel B, Szabo C, Mai PL, Loud JT, Lubinski J; CIMBA, the Consortium of Investigators of Modifiers of BRCA1/2-Related Cancer. Association of PHB 1630 C�T and MTHFR 677C�T polymorphisms with breast and ovarian cancer risk in BRCA1/2 mutation carriers: results from a multicenter study. Br J Cancer 2012; 106: 2016- 2024 (AMC/NKI/VUmc)

761. Jamnitski A, Krieckaert CL, Nurmohamed MT, Hart MH, Dijkmans BA, Aarden L, Voskuyl AE, Wolbink GJ. Patients non-responding to etanercept obtain lower etanercept concentrations compared with responding patients. Annals of the Rheumatic Diseases 2012; 71: 88-91. (VUmc)

762. Jamshidi M, Schmidt MK, Dörk T et al. Germline variation in TP53 regulatory network genes associates with breast cancer survival and treatment outcome. Int J Cancer. 2012 (NKI)

763. Jansen EPM, Boot H, van de Velde CJH, van Sandick JW, Cats A, Verheij M. Can adjuvant chemoradiotherapy replace extended lymph node dissection in gastric cancer? Recent Results Cancer Res 2012; 196: 229-40 (NKI)

764. Jansen IDC, Vermeer JAF, Bloemen V, Stap J, Everts V. Osteoclast fusion and fission. Calcified Tissue International 2012; 90(6): 515-522. (AMC)

765. Jansen IDC, Vermeer JAF, Bloemen V, Stap J, Everts V. Osteoclast Fusion and Fission : authors' reply. Calcified Tissue International 2012; 91(2): 159-. (AMC)

766. Jansen MHA, van Vuurden DG, Vandertop WP, Kaspers GJL. Diffuse intrinsic pontine gliomas: A systematic update on clinical trials and biology. Cancer Treatment Reviews 2012; 38: 27-35. (VUmc)

767. Jansen MHA, Veringa SJ, van Vuurden DG, van Dalen EJ, Kaspers GJL. Temozolomide for children and adolescents with diffuse intrinsic pontine glioma. Cochrane Database Syst Rev 2012; : . (VUmc)

768. Jansen RS, Rosing H, Wijermans PW, Keizer RJ, Schellens JH, Beijnen JH. Decitabine triphosphate levels in peripheral blood mononuclear cells from patients receiving prolonged lowdose decitabine administration: a pilot study. Cancer Chemother Pharmacol 2012; 69: 1457-66 (NKI)

769. Jansen S, Perrakis A, Ulens C, Winkler C, Andries M, Joosten RP, Van Acker M, Luyten FP, Moolenaar WH, Bollen M. Structure of NPP1, an ectonucleotide pyrophosphatase/phosphodiesterase involved in tissue calcification. Structure 2012; 20: 1948-59 (NKI)

770. Jansen TL, Mulder CJJ. Rheumatology meets hepatology in 2012: a clinician's guideline for TNF inhibitors in hepatitis B/C virus carriers. Expert Opinion on Biological Therapy 2012; 12: 391-393. (VUmc)

771. Janssen JJWM, Deenik W, Smolders KGM, van Kuijk BJ, Pouwels W, Kelder A, Cornelissen JJ, Schuurhuis GJ, Ossenkoppele GJ. Residual normal stem cells can be detected in newly diagnosed chronic myeloid leukemia patients by a new flow cytometric approach and predict for optimal response to imatinib. Leukemia 2012; 26: 977-984. (VUmc)

772. Janssen-Heijnen MLG, Karim-Kos HE, van der Drift MA, Groen HJM, Ho VKY, Koning C, de Vries E. Modest Improvements of Survival for Patients with Small Cell Lung Cancer Aged 45 to 59 Years Only, Diagnosed in the Netherlands, 1989 to 2008. Journal Of Thoracic Oncology 2012; 7(1): 227-232. (AMC)

773. Janssen-Heijnen MLG, Maas HAAM, Siesling S, Koning CCE, Coebergh JWW, Groen HJM. Treatment and survival of patients with small-cell lung cancer: small steps forward, but not for patients >80. Annals Of Oncology 2012; 23(4): 954-960. (AMC)

774. Janssens GO, Rademakers SE, Terhaard CH, Doornaert PA, Bijl HP, van den Ende P, Chin A, Marres HA, de Bree R, van der Kogel AJ, Hoogsteen IJ, Bussink J, Span PN, Kaanders JH. Accelerated Radiotherapy With Carbogen and Nicotinamide for Laryngeal Cancer: Results of a Phase III Randomized Trial. J Clin Oncol 2012; 30: 1777-1783. (VUmc)

775. Janssens GO, Terhaard CH, Doornaert PA, Bijl HP, van den Ende P, Chin A, Pop LA, Kaanders JH. Acute Toxicity Profile and Compliance to Accelerated Radiotherapy Plus Carbogen and Nicotinamide for Clinical Stage T2-4 Laryngeal Cancer: Results of A Phase Iii Randomized Trial. International Journal of Radiation Oncology Biology Physics 2012; 82: 532-538. (VUmc)

776. Jarzyna PA, Deddens LH, Kann BH, Ramachandran S, Calcagno C, Chen W, Gianella A, Dijkhuizen RM, Griffioen AW, Fayad ZA, Mulder WJM. Tumor Angiogenesis Phenotyping by Nanoparticle-facilitated Magnetic Resonance and Near-infrared Fluorescence Molecular Imaging. Neoplasia 2012; 14: 964-973. (VUmc)

777. Jaspers J, Kersbergen A, Boon U, Sol W, van Deemter L, Zander SA, Drost R, Wientjens E, Ji J, Aly A, Doroshow JH, Cranston A, Martin NM, Lau A, O’Connor MJ, Ganesan S, Borst P, Jonkers J*, Rottenberg S*. Loss of 53BP1 causes PARP inhibitor resistance in BRCA1-mutated mouse mammary tumors. Cancer Discov. 2012 (* joint corresponding authors) (NKI)

778. Jaspers JE, Kersbergen A, Boon U, et al. Loss of 53BP1 causes PARP inhibitor resistance in BRCA1-mutated mouse mammary tumors. Cancer Discovery 2012 (NKI)


779. Jellema HM, Saeed P, Everhard-Halm Y, Prick L, Mourits M. Bilateral inferior rectus muscle recession in patients with graves orbitopathy: is it effective? Ophthalmic Plastic And Reconstructive Surgery 2012; 28(4): 268-272. (AMC)

780. Jenal M, Elkon R, Loayza-Puch F, van Haaften G, Kuhn U, Menzies FM, Oude Vrielink JA, Bos AJ, Drost J, Rooijers, K, Rubinsztein DC, Agami R. The poly(A)-binding protein nuclear 1 suppresses alternative cleavage and polyadenylation sites. Cell 2012; 149: 538-553 (NKI)

781. Jharap B, Koudstaal LG, Neefjes-Borst EA, Van Weyenberg SJB. Colonic telangiectasias in progressive systemic sclerosis. Endoscopy 2012; 44: E42-E43. (VUmc)

782. Jharap B, Seinen ML, van Bodegraven AA, de Boer NK. Intrauterine exposure to thiopurines. Reproductive Toxicology 2012; 33: 124. (VUmc)

783. Jia X, Tian Z, Lou Y, Sonke JJ, Jiang SB. Four-dimensional cone beam CT reconstruction and enhancement using a temporal nonlocal means method. Med Phys 2012; 39: 5592-602 (NKI)

784. Jiang J, Karimi O, Ouburg S, Champion CI, Khurana A, Liu GC, Freed A, Pleijster J, Rozengurt N, Land JA, Surcel HM, Tiitinen A, Paavonen J, Kronenberg M, Morre SA, Kelly KA. Interruption of CXCL13-CXCR5 Axis Increases Upper Genital Tract Pathology and Activation of NKT Cells following Chlamydial Genital Infection. PloS one 2012; 7: . (VUmc)

785. Jin Y, Birlea SA, Fain PR, Ferrara TM, Ben S, Riccardi SL, Cole JB, Gowan K, Holland PJ, Bennett DC, Luiten RM, Wolkerstorfer A, van der Veen JPW, Hartmann A, Eichner S, Schuler G, van Geel N, Lambert J, Kemp EH, Gawkrodger DJ, Weetman AP, Taïeb A, Jouary T, Ezzedine K, Wallace MR, McCormack WT, Picardo M, Leone G, Overbeck A, Silverberg NB, Spritz RA. Genome-wide association analyses identify 13 new susceptibility loci for generalized vitiligo. Nature Genetics 2012; 44(6): 676-680. (AMC)

786. Jobsen JJ, Aarts MJ, Siesling S, Klaase J, Louwman WJ, Poortmans PMP, Lybeert MLM, Koning CCE, Struikmans H, Coebergh JWW. Use of primary radiotherapy for rectal cancer in the Netherlands between 1997 and 2008: a population-based study. Clinical Oncology 2012; 24(1): e1-e8. (AMC)

787. Joerger M, Burgers JA, Baas P, Doodeman VD, Smits PH, Jansen RS, Vainchtein LD, Rosing H, Huitema AD, Beijnen JH, Schellens JH. Gene polymorphisms, pharmacokinetics, and hematological toxicity in advanced non-small-cell lung cancer patients receiving cisplatin/gemcitabine. Cancer Chemother Pharmacol 2012; 69: 25-33 (NKI)

788. Joerger M, Burgers SA, Baas P, Smit EF, Haitjema TJ, Bard MP, Doodeman VD, Smits PH, Vincent A, Huitema AD, Beijnen JH, Schellens JH. Germline polymorphisms in patients with advanced nonsmall cell lung cancer receiving first-line platinum-gemcitabine chemotherapy: a prospective clinical study. Cancer 2012; 118: 2466-75 (NKI/VUmc)

789. Joerger M, Ferreri AJ, Krähenbühl S, Schellens JH, Cerny T, Zucca E, Huitema AD. Dosing algorithm to target a predefined AUC in patients with primary central nervous system lymphoma receiving high dose methotrexate. Br J Clin Pharmacol 2012; 73: 240-7 (NKI)

790. Joerger M, Kraff S, Huitema AD, Feiss G, Moritz B, Schellens JH, Beijnen JH, Jaehde U. Evaluation of a pharmacology-driven dosing algorithm of 3-weekly paclitaxel using therapeutic drug monitoring: a pharmacokineticpharmacodynamic simulation study. Clin Pharmacokinet 2012; 51: 607-17 (NKI)

791. Jones DTW, Jäger N, Kool M, Zichner T, Hutter B, Sultan M, Cho YJ, Pugh TJ, Hovestadt V, Stütz AM, Rausch T, Warnatz H, Ryzhova M, Bender S, Sturm D, Pleier S, Cin H, Pfaff E, Sieber L, Wittmann A, Remke M, Witt H, Hutter S, Tzaridis T, Weischenfeldt J, Raeder B, Avci M, Amstislavskiy V, Zapatka M, Weber UD, Wang Q, Lasitschka B, Bartholomae CC, Schmidt M, von Kalle C, Ast V, Lawerenz C, Eils J, Kabbe R, Benes V, van Sluis P, Koster J, Volckmann R, Shih D, Betts MJ, Russell RB, Coco S, Tonini GP, Schüller U, Hans V, Graf N, Kim YJ, Monoranu C, Roggendorf W, Unterberg A, Herold-Mende C, Milde T, Kulozik AE, von Deimling A, Witt O, Maass E, Rössler J, Ebinger M, Schuhmann MU, Frühwald MC, Hasselblatt M, Jabado N, Rutkowski S, von Bueren AO, Williamson D, Clifford SC, McCabe MG, Collins VP, Wolf S, Wiemann S, Lehrach H, Brors B, Scheurlen W, Felsberg J, Reifenberger G, Northcott PA, Taylor MD, Meyerson M, Pomeroy SL, Yaspo M, Korbel JO, Korshunov A, Eils R, Pfister SM, Lichter P. Dissecting the genomic complexity underlying medulloblastoma. Nature 2012; 488(7409): 100-105. (AMC)

792. Jones ME, van Leeuwen FE, Hoogendoorn WE, Mourits MJ, Hollema H, van Boven H, Press MF, Bernstein L, Swerdlow AJ. Endometrial cancer survival after breast cancer in relation to tamoxifen treatment: pooled results from three countries. Breast Cancer Res 2012; 14: R91 (NKI)

793. Jones S, Li M, Parsons DW, Zhang X, Wesseling J, Kristel P, Schmidt MK, Markowitz S, Yan H, Bigner D, Hruban RH, Eshleman JR, Iacobuzio-Donahue CA, Goggins M, Maitra A, Malek SN, Powell S, Vogelstein B, Kinzler KW, Velculescu VE, Papadopoulos N. Somatic mutations in the chromatin remodeling gene ARID1A occur in several tumor types. Hum Mutat 2012; 33: 100-3 (NKI)

794. Jonkers J. Tracking evolution of BRCA1-associated breast cancer. Cancer Discov 2012; 2: 486-8 (NKI) 795. Jonsdottir K, Janssen SR, Da Rosa FC, Gudlaugsson E, Skaland I, Baak JPA, Janssen EAM. Validation of Expression

Patterns for Nine miRNAs in 204 Lymph-Node Negative Breast Cancers. PloS one 2012; 7: . (VUmc) 796. Jonsdottir K, Zhang H, Jhagroe D, Skaland I, Slewa A, Bjorkblom B, Coffey ET, Gudlaugsson E, Smaaland R, Janssen

EAM, Baak JPA. The prognostic value of MARCKS-like 1 in lymph node-negative breast cancer. Breast Cancer Research and Treatment 2012; 135: 381-390. (VUmc)

797. Jonsson F, Mancardi DA, Zhao W, Kita Y, Iannascoli B, Khun H, Van Rooijen N, Shimizu T, Schwartz LB, Daeron M, Bruhns P. Human Fc gamma RIIA induces anaphylactic and allergic reactions. Blood 2012; 119: 2533-2544. (VUmc)

798. Joosse SA, Brandwijk KI, Devilee P, Wesseling J, Hogervorst FB, Verhoef S, Nederlof PM. Prediction of BRCA2- association in hereditary breast carcinomas using array-CGH. Breast Cancer Res Treat 2012; 132: 379-389 (NKI)

799. Joosten RP, Joosten K, Murshudov GN, Perrakis A. PDB_REDO: constructive validation, more than just looking for errors. Acta Crystallogr D Biol Crystallogr 2012; 68: 484-96 (NKI)

800. Jose J, Willemink RGH, Steenbergen W, Slump CH, van Leeuwen TG, Manohar S. Speed-of-sound compensated photoacoustic tomography for accurate imaging. Medical Physics 2012; 39(12): 7262-7271. (AMC)

801. Joseph SJ, Didelot X, Rothschild J, de Vries HJC, Morre SA, Read TD, Dean D. Population Genomics of Chlamydia trachomatis: Insights on Drift, Selection, Recombination, and Population Structure. Molecular Biology and Evolution 2012; 29: 3933-3946. (VUmc)

802. Joshi MD, Unger WJ, Storm G, van Kooyk Y, Mastrobattista E. Targeting tumor antigens to dendritic cells using particulate carriers. Journal of Controlled Release 2012; 161: 25-37. (VUmc)

803. Joustra PE, Kolfin R, van Dijk NM, Koning CCE, Bakker PJM. Reduce fluctuations in capacity to improve the accessibility of radiotherapy treatment cost-effectively. Flexible Services And Manufacturing Journal 2012; 24(4): 448-464. (AMC)


804. Jung M, Riedmann D, Hackl WO, Hoerbst A, Jaspers MW, Ferret L, Lawton K, Ammenwerth E. Physicians' perceptions on the usefulness of contextual information for prioritizing and presenting alerts in Computerized Physician Order Entry systems. BMC Medical Informatics And Decision Making 2012; 12: 111-. (AMC)

805. Kadouch DJM, maas SM, Dubois L, van der Horst CMAM. Surgical treatment of macroglossia in patients with Beckwith-Wiedemann syndrome: a 20-year experience and review of the literature. International Journal Of Oral And Maxillofacial Surgery 2012; 41(3): 300-308. (AMC)

806. Kahraman D, Holstein A, Scheffler M, Zander T, Nogova L, Lammertsma AA, Boellaard R, Neumaier B, Dietlein M, Wolf J, Kobe C. Tumor Lesion Glycolysis and Tumor Lesion Proliferation for Response Prediction and Prognostic Differentiation in Patients With Advanced Non-Small Cell Lung Cancer Treated With Erlotinib. Clinical Nuclear Medicine 2012; 37: 1058-1064. (VUmc)

807. Kaiser AD, Schuster K, Gadiot J, Borkner L, Daebritz H, Schmitt C, Andreesen R, Blank C. Reduced tumor-antigen density leads to PD-1/ PD-L1 mediated impairment of partially exhausted CD8(+) T cells. Eur J Immunol 2012; 42: 662-71 (NKI)

808. Kalay H, Ambrosini M, van Berkel PHC, Parren PWHI, van Kooyk Y, Vallejo JJG. Online nanoliquid chromatography-mass spectrometry and nanofluorescence detection for high-resolution quantitative N-glycan analysis. Analytical Biochemistry 2012; 423: 153-162. (VUmc)

809. Kaljouw E, Pieters B, Koedooder K, Lucas C, Koning C. Benefits of a dual sagittal crystal transducer for ultrasound imaging during I-125 seed implantation for permanent prostate brachytherapy. Journal Of Contemporary Brachytherapy 2012; 4(3): 141-145. (AMC)

810. Kalkman J, Bykov AV, Streekstra GJ, van Leeuwen TG. Multiple scattering effects in Doppler optical coherence tomography of flowing blood. Physics In Medicine And Biology 2012; 57(7): 1907-1917. (AMC)

811. Kallenberg MGJ, van Gils CH, Lokate M, den Heeten GJ, Karssemeijer N. Effect of compression paddle tilt correction on volumetric breast density estimation. Physics In Medicine And Biology 2012; 57(16): 5155-5168. (AMC)

812. Kaminski MF, Bretthauer M, Zauber AG, Kuipers EJ, Adami HO, van Ballegooijen M, Regula J, van Leerdam M, Stefansson T, Påhlman L, Dekker E, Hernán MA, Garborg K, Hoff G. The NordICC Study: rationale and design of a randomized trial on colonoscopy screening for colorectal cancer. Endoscopy 2012; 44(7): 695-702. (AMC/NKI)

813. Kammeyer A, Peters CP, Meijer SL, te Velde AA. Anti-Inflammatory Effects of Urocanic Acid Derivatives in Models Ex Vivo and In Vivo of Inflammatory Bowel Disease. ISRN Inflammation 2012; p.1-8. (AMC)

814. Kanga S, Bernard D, Mager-Heckel AM, Erpapazoglou Z, Mattiroli F, Sixma TK, Leon S, Urban-Grimal D, Tarassov I, Haguenauer-Tsapis R. A deubiquitylating complex required for neosynthesis of a yeast mitochondrial ATP synthase subunit. PLoS One 2012; 7 (NKI)

815. Kanthawong S, Bolscher JGM, Veerman ECI, van Marle J, de Soet HJJ, Nazmi K, Wongratanacheewin S, Taweechaisupapong S. Antimicrobial and antibiofilm activity of LL-37 and its truncated variants against Burkholderia pseudomallei. International Journal Of Antimicrobial Agents 2012; 39(1): 39-44. (AMC)

816. Kapidzic A, Korfage IJ, van Dam L, van Roon AH, Reijerink JC, Zauber AG, van Ballegooijen M, Kuipers EJ, van Leerdam ME. Quality of life in participants of a CRC screening program. Br J Cancer 2012; 107: 1295- 301 (NKI)

817. Karagozoglu KH, Buter J, Leemans CR, Rietveld DHF, van den Vijfeijken S, van der Waal I. Subset of patients with verrucous carcinoma of the oral cavity who benefit from treatment with methotrexate. British Journal of Oral & Maxillofacial Surgery 2012; 50: 513-518. (VUmc)

818. Karakullukcu B, Nyst HJ, van Veen RL, Hoebers FJ, Hamming-Vrieze O, Witjes MJ, de Visscher SA, Burlage FR, Levendag PC, Sterenborg HJ, Tan IB. mTHPC mediated interstitial photodynamic therapy of recurrent nonmetastatic base of tongue cancers: Development of a new method. Head Neck 2012; 34: 1597-60 (NKI)

819. Karakullukçu B, van der Vlies D, Hoebers FJ. A rare late complication after concomitant chemoradiation of an oropharyngeal tumor: cervical necrotizing fasciitis. Kulak Burun Bogaz Ihtis Derg 2012; 22: 105-8 (NKI)

820. Karras D, Stoykov I, Lems WF, Langdahl BL, Ljunggren O, Barrett A, Walsh JB, Fahrleitner-Pammer A, Rajzbaum G, Jakob F, Marin F. Effectiveness of Teriparatide in Postmenopausal Women with Osteoporosis and Glucocorticoid Use: 3-Year Results from the EFOS Study. Journal of Rheumatology 2012; 39: 600-609. (VUmc)

821. Karrich JJ, Balzarolo M, Schmidlin H, Libouban M, Nagasawa M, Gentek R, Kamihira S, Maeda T, Amsen D, Wolkers MC, Blom B. The transcription factor Spi-B regulates human plasmacytoid dendritic cell survival through direct induction of the antiapoptotic gene BCL2-A1. Blood 2012; 119(22): 5191-5200. (AMC)

822. Kaspers GJ, Jansen MH. A new era for children with diffuse intrinsic pontine glioma: hope for cure?. Expert Rev Anticancer Ther 2012; 12: 1109-1112. (VUmc)

823. Kaspers GJL. Pediatric acute myeloid leukemia. Expert Review of Anticancer Therapy 2012; 12: 405-413. (VUmc) 824. Kasza I, Varady G, Andrikovics H, Koszarska M, Tordai A, Scheffer GL, Nemeth A, Szakacs G, Sarkadi B. Expression

Levels of the ABCG2 Multidrug Transporter in Human Erythrocytes Correspond to Pharmacologically Relevant Genetic Variations. PloS one 2012; 7: e48423. (VUmc)

825. Kater AP, Chamuleau ME, Posthuma W, Schipperus MR, Spiering M, van Oers MH. HOVON 109: de effectiviteit en veiligheid van eerstelijnsbehandeling van chronische lymfatische leukemie met chloorambucil, rituximab en lenalidomide bij oudere patienten en patienten met comorbiditeit; een fase I/II-studie. Nederlands Tijdschrift Voor Hematologie 2012; 9: 197-. (AMC)

826. Kater AP, Shanafelt T, Fischer K, Wierda W. Highlights of the 6th Young Investigators' Meeting on chronic lymphocytic leukemia. Leukemia & Lymphoma 2012; 53(11): 2312-2313. (AMC)

827. Kaye S, Aamdal S, Jones R, Freyer G, Pujade-Lauraine E, de Vries EGE, Barriuso J, Sandhu S, Tan DSW, Hartog V, Kuenen B, Ruijter R, Kristensen GB, Nyakas M, Barrett S, Burke W, Pietersma D, Stuart M, Emeribe U, Boven E. Phase I study of saracatinib (AZD0530) in combination with paclitaxel and/or carboplatin in patients with solid tumours. Br J Cancer 2012; 106: 1728-1734. (VUmc)

828. Kazemier G. Unresectable colorectal cancer liver metastases treated by intraoperative radiofrequency ablation with or without resection (Br J Surg 2012; 99: 558-565). British Journal of Surgery 2012; 99: 566. (VUmc)

829. Keizer RJ, Gupta A, Shumaker R, Beijnen JH, Schellens JH, Huitema AD. Model-based treatment optimization of a novel VEGFR inhibitor. Br J Clin Pharmacol 2012; 74: 315-26 (NKI)

830. Keizer RJ, Zandvliet AS, Beijnen JH, Schellens JH, Huitema AD. Performance of methods for handling missing categorical covariate data in population pharmacokinetic analyses. AAPS J 2012; 14: 601-11 (NKI)

831. Keizer RJ, Zandvliet AS, Beijnen JH, Schellens JH, Huitema AD. Two-stage model-based design of cancer phase I dose escalation trials: evaluation using the phase I program of barasertib (AZD1152). Invest New Drugs 2012; 30: 1519-30 (NKI)


832. Kemper K, Medema JP. Prognostic Value of CD133 Caused by Mutant K-Ras and B-Raf--Response. Clinical Cancer Research 2012; 18(16): 4474-. (AMC)

833. Kemper K, Prasetyanti PR, de Lau W, Rodermond H, Clevers H, Medema JP. Monoclonal antibodies against Lgr5 identify human colorectal cancer stem cells. Stem Cells 2012; 30(11): 2378-2386. (AMC)

834. Kemper K, Rodermond H, Colak S, Grandela C, Medema JP. Targeting colorectal cancer stem cells with inducible caspase-9. Apoptosis 2012; 17(5): 528-537. (AMC)

835. Kemper K, Versloot M, Cameron K, Colak S, de Sousa e Melo F, de Jong JH, Bleackley J, Vermeulen L, Versteeg R, Koster J, Medema JP. Mutations in the Ras-Raf Axis underlie the prognostic value of CD133 in colorectal cancer. Clinical Cancer Research 2012; 18(11): 3132-3141. (AMC)

836. Kenemans P, van der Mooren MJ. Androgens and breast cancer risk. Gynecological Endocrinology 2012; 28: 46-49. (VUmc)

837. Kenter G, Wijma S. 125 jaar NVOG. Nederlands Tijdschrift Voor Geneeskunde 2012; 155(27): A5178-. (AMC/NKI) 838. Kerr AC, Ferguson J, Haylett AK, Rhodes LE, Adamski H, Alomar A, Serra E, Antoniou C, Aubin F, Vigan M, Biedermann

T, Fischer J, Bourrain JL, Bruynzeel D, Rustemeyer T, Carrascosa JM, Chowdhury MMU, de la Cuadra J, Foti C, Gardeazabal J, Gawkrodger DJ, Gimenez-Arnau A, Goncalo M, Goossens A, Ibbotson SH, Dawe RS, Lecha M, Marguery MC, Neumann NJ, Niklasson B, Peyron JL, Pigatto P, Spiewak R, Stone N, Tanew A, Thomas P, Bonnevalle A, Wilkinson SM, Wolf P, Gruber-Wackernagel A, Wulf HC. A European multicentre photopatch test study The European Multicentre Photopatch Test Study (EMCPPTS) Taskforce. British Journal of Dermatology 2012; 166: 1002-1009. (VUmc)

839. Kersseboom R, Dubbink HJ, Corver WE, van Tilburg AJ, Poley JW, van Leerdam ME, Atmodimedjo PN, van de Laar IM, Collée JM, Dinjens WN, Morreau H, Wagner A. PTEN in colorectal cancer: a report on two Cowden syndrome patients. Clin Genet 2012; 81: 555-62 (NKI)

840. Kersten MJ, Doorduijn JK, de Jong D, Zijlstra-Baalbergen JM, Ghidey W, Spiering M, Steijaert M, Meulendijks I, Hagenbeek A. ReBel studie: een gerandomiseerde fase I/II studie naar de effectiviteit en veiligheid van behandeling met lenalidomide en rituximab, met of zonder bendamustine, bij volwassen patienten met recidief folliculair lymfoom. Nederlands Tijdschrift Voor Hematologie 2012; 9: 71-. (AMC)

841. Keszthelyi D, Dackus GH, Masclee GM, Kruimel JW, Masclee AA. Increased proton pump inhibitor and NSAID exposure in irritable bowel syndrome: results from a case-control study. BMC Gastroenterol 2012; 12: 121 (NKI)

842. Ketema M. Nesprin-3 as a LINC between the nucleus and intermediate filaments. PhD thesis. Amsterdam: University of Amsterdam, 2012. (NKI)

843. Khashab MA, Fockens P, Al-Haddad MA. Utility of EUS in patients with indeterminate biliary strictures and suspected extrahepatic cholangiocarcinoma (with videos). Gastrointestinal Endoscopy 2012; 76(5): 1024-1033. (AMC)

844. Khodakarami N, Clifford GM, Yavari P, Farzaneh F, Salehpour S, Broutet N, Bathija H, Heideman DAM, van Kemenade FJ, Meijer CJLM, Hosseini SJ, Franceschi S. Human papillomavirus infection in women with and without cervical cancer in Tehran, Iran. International Journal of Cancer 2012; 131: E156-E161. (VUmc)

845. Khorsand N, Veeger NJGM, van Hest RM, Ypma PF, Heidt J, Meijer K. An observational, prospective, two-cohort comparison of a fixed versus variable dosing strategy of prothrombin complex concentrate to counteract vitamin K antagonists in 240 bleeding emergencies. Haematologica-The Hematology Journal 2012; 97(10): 1501-1506. (AMC)

846. Khoshnevisan A, Yekaninejad MS, Ardakani SK, Pakpour AH, Mardani A, Aaronson NK Translation and validation of the EORTC brain cancer module (EORTC QLQ-BN20) for use in Iran. Health Qual Life Outcomes 2012; 10: 54 (NKI)

847. Kilsdonk E, Riezebos R, Kremer L, Peute L, Jaspers M. Clinical guideline representation in a CDS: a human information processing method. Studies In Health Technology And Informatics 2012; 180: 427-431. (AMC)

848. Kimberley FC, van der Sloot AM, Guadagnoli M, Cameron K, Schneider P, Marquart JA, Versloot M, Serrano L, Medema JP. The design and characterization of receptor-selective APRIL variants. Journal Of Biological Chemistry 2012; 287(44): 37434-37446. (AMC)

849. King-Kallimanis BL, ter Hoeven CL, de Haes H, Smets E, Koning C, Oort F. Compariison of procedures used to test measurement invariance in longitudinal factor analysis. Netherlands Journal Of Psychology 2012; 67(3): 91-100. (AMC)

850. King-Kallimanis BL, ter Hoeven CL, de Haes HC, Smets EM, Koning CCE, Oort FJ. Assessing measurement invariance of a health-related quality-of-life questionnaire in radiotherapy patients. Quality Of Life Research 2012; 21(10): 1745-1753. (AMC)

851. Kinsler V, Shaw AC, Merks JH, Hennekam RC. The face in congenital melanocytic nevus syndrome. American Journal Of Medical Genetics Part A 2012; 158AA(5): 1014-1019. (AMC)

852. Kirchhoff T, Gaudet MM, Antoniou AC, McGuffog L, Humphreys MK, Dunning AM, Bojesen SE, Nordestgaard BG, Flyger H, Kang D, Yoo KY, Noh DY, Ahn SH, Dork T, Schürmann P, Karstens JH, Hillemanns P, Couch FJ, Olson J, Vachon C, Wang X, Cox A, Brock I, Elliott G, Reed MWR, Burwinkel B, Meindl A, Brauch H, Hamann U, Ko YD, Broeks A, Schmidt MK, van 't Veer LJ, Braaf LM, Johnson N, Fletcher O, Gibson L, Peto J, Turnbull C, Seal S, Renwick A, Rahman N, Wu PE, Yu JC, Hsiung CN, Shen CY, Southey MC, Hopper JL, Hammet F, van Dorpe T, Dieudonne AS, Hatse S, Lambrechts D, Andrulis IL, Bogdanova N, Antonenkova N, Rogov JI, Prokofieva D, Bermisheva M, Khusnutdinova E, van Asperen CJ, Tollenaar RAEM, Hooning MJ, Devilee P, Margolin S, Lindblom A, Milne RL, Arias JI, Zamora MP, Benítez J, Severi G, Baglietto L, Giles GG, Spurdle AB, Beesley J, Chen X, Holland H, Healey S, Wang-Gohrke S, Chang-Claude J, Mannermaa A, Kosma VM, Kauppinen J, Kataja V, Agnarsson BA, Caligo MA, Godwin AK, Nevanlinna H, Heikkinen T, Fredericksen Z, Lindor N, Nathanson KL, Domchek SM, Loman N, Karlsson P, Stenmark-Askmalm M, Melin B, von Wachenfeldt A, Hogervorst FBL, Verheus M, Rookus MA, Seynaeve C, Oldenburg RA, Ligtenberg MJ, Ausems MGEM, Aalfs CM, Gille HJP, Wijnen JT, Gómez García EB, Peock S, Cook M, Oliver CT, Frost D, Luccarini C, Pichert G, Davidson R, Chu C, Eccles D, Ong KR, Cook J, Douglas F, Hodgson S, Evans DG, Eeles R, Gold B, Pharoah PDP, Offit K, Chenevix-Trench G, Easton DF. Breast cancer risk and 6q22.33: combined results from Breast Cancer Association Consortium and Consortium of Investigators on Modifiers of BRCA1/2. Plos One 2012; 7(6): e35706-. (AMC/NKI/VUmc)

853. Kiriyama S, Takada T, Strasberg SM, Solomkin JS, Mayumi T, Pitt HA, Gouma DJ, Garden OJ, Büchler MW, Yokoe M, Kimura Y, Tsuyuguchi T, Itoi T, Yoshida M, Miura F, Yamashita Y, Okamoto K, Gabata T, Hata J, Higuchi R, Windsor JA, Bornman PC, Fan ST, Singh H, de Santibanes E, Gomi H, Kusachi S, Murata A, Chen XP, Jagannath P, Lee S, Padbury R, Chen MF. New diagnostic criteria and severity assessment of acute cholangitis in revised Tokyo Guidelines. Journal Of Hepato-Biliary-Pancreatic Sciences 2012; 19(5): 548-556. (AMC)

854. Kirsch M, Crombez P, Calza S, Eeltink C, Johansson E. Patient information in stem cell transplantation from the perspective of health care professionals: A survey from the Nurses Group of the European Group for Blood and Marrow Transplantation. Bone Marrow Transplantation 2012; 47: 1131-1133. (VUmc)


855. Klarenbeek BR, de Korte N, van der Peet DL, Cuesta MA. Review of current classifications for diverticular disease and a translation into clinical practice. International Journal of Colorectal Disease 2012; 27: 207-214. (VUmc)

856. Klarenbeek PL, de Hair MJH, Doorenspleet ME, van Schaik BDC, Esveldt REE, van de Sande MGH, Cantaert T, Gerlag DM, Baeten D, van Kampen AHC, Baas F, Tak PP, de Vries N. Inflamed target tissue provides a specific niche for highly expanded T-cell clones in early human autoimmune disease. Annals Of The Rheumatic Diseases 2012; 71(6): 1088-1093. (AMC)

857. Klarenbeek PL, Remmerswaal EBM, ten Berge IJM, Doorenspleet ME, van Schaik BDC, Esveldt REE, Koch SD, ten Brinke A, van Kampen AHC, Bemelman FJ, Tak PP, Baas F, de Vries N, van Lier RAW. Deep sequencing of antiviral T-cell responses to HCMV and EBV in humans reveals a stable repertoire that is maintained for many years. PLOS Pathogens 2012; 8(9): e1002889-. (AMC)

858. Klaver YLB, Simkens LHJ, Lemmens VEPP, Koopman M, Teerenstra S, Bleichrodt RP, de Hingh IHJT, Punt CJA. Outcomes of colorectal cancer patients with peritoneal carcinomatosis treated with chemotherapy with and without targeted therapy. European Journal Of Surgical Oncology 2012; 38(7): 617-623. (AMC)

859. Kleibeuker EA, Griffioen AW, Verheul HM, Slotman BJ, Thijssen VL. Combining angiogenesis inhibition and radiotherapy: A double-edged sword. Drug Resistance Updates 2012; 15: 173-182. (VUmc)

860. Klein M, Duffau H, Hamer PCD. Cognition and resective surgery for diffuse infiltrative glioma: an overview. Journal of Neuro-Oncology 2012; 108: 309-318. (VUmc)

861. Klein M, Schagen SB. Klinische Neuropsychologie. Intracraniale en extracraniale tumoren bij volwassenen. 2012, Uitgeverij Boom (NKI)

862. Klein M. Neurocognitive functioning in adult WHO grade II gliomas: impact of old and new treatment modalities. Neuro-oncology 2012; 14: 17-24. (VUmc)

863. Kleinjan A, Böing AN, Sturk A, Nieuwland R. Microparticles in vascular disorders: how tissue factor-exposing vesicles contribute to pathology and physiology. Thrombosis Research 2012; 130(Suppl. 1): S71-S73. (AMC)

864. Klerkx WM, Veldhuis WB, Spijkerboer AM, van den Bosch MA, Mali WP, Heintz AP, Bipat S, Sie-Go DM, van der Velden J, Schreuder HW, Stoker J, Peeters PH. The value of 3.0Tesla diffusion-weighted MRI for pelvic nodal staging in patients with early stage cervical cancer. European Journal Of Cancer 2012; 48(18): 3414-3421. (AMC)

865. Klionsky DJ, Abdalla FC, Abeliovich H, Abraham RT, cevedo-Arozena A, Adeli K, Agholme L, Agnello M, Agostinis P, guirre-Ghiso JA, Ahn HJ, it-Mohamed O, it-Si-Ali S, Akematsu T, Akira S, Al-Younes HM, Al-Zeer MA, Albert ML, Albin RL, egre-Abarrategui J, Aleo MF, Alirezaei M, Almasan A, monte-Becerril M, Amano A, Amaravadi R, Amarnath S, Amer AO, ndrieu-Abadie N, Anantharam V, Ann DK, noopkumar-Dukie S, Aoki H, Apostolova N, Arancia G, Aris JP, Asanuma K, Asare NYO, Ashida H, Askanas V, Askew DS, Auberger P, Baba M, Backues SK, Baehrecke EH, Bahr BA, Bai XY, Bailly Y, Baiocchi R, Baldini G, Balduini W, Ballabio A, Bamber BA, Bampton ETW, Banhegyi G, Bartholomew CR, Bassham DC, Bast RC, Batoko H, Bay BH, Beau I, Bechet DM, Begley TJ, Behl C, Behrends C, Bekri S, Bellaire B, Bendall LJ, Benetti L, Berliocchi L, Bernardi H, Bernassola F, Besteiro S, Bhatia-Kissova I, Bi XN, Biard-Piechaczyk M, Blum JS, Boise LH, Bonaldo P, Boone DL, Bornhauser BC, Bortoluci KR, Bossis I, Bost F, Bourquin JP, Boya P, Boyer-Guittaut M, Bozhkov PV, Brady NR, Brancolini C, Brech A, Brenman JE, Brennand A, Bresnick EH, Brest P, Bridges D, Bristol ML, Brookes PS, Brown EJ, Brumell JH, Brunetti-Pierri N, Brunk UT, Bulman DE, Bultman SJ, Bultynck G, Burbulla LF, Bursch W, Butchar JP, Buzgariu W, Bydlowski SP, Cadwell K, Cahova M, Cai DS, Cai JY, Cai Q, Calabretta B, Calvo-Garrido J, Camougrand N, Campanella M, Campos-Salinas J, Candi E, Cao LZ, Caplan AB, Carding SR, Cardoso SM, Carew JS, Carlin CR, Carmignac V, Carneiro LAM, Carra S, Caruso RA, Casari G, Casas C, Castino R, Cebollero E, Cecconi F, Celli J, Chaachouay H, Chae HJ, Chai CY, Chan DC, Chan EY, Chang RCC, Che CM, Chen CC, Chen GC, Chen GQ, Chen M, Chen Q, Chen SSL, Chen WL, Chen X, Chen XM, Chen XQ, Chen YG, Chen YY, Chen YQ, Chen YJ, Chen ZX, Cheng A, Cheng CHK, Cheng Y, Cheong H, Cheong JH, Cherry S, Chess-Williams R, Cheung ZH, Chevet E, Chiang HL, Chiarelli R, Chiba T, Chin LS, Chiou SH, Chisari FV, Cho CH, Cho DH, Choi AMK, Choi D, Choi KS, Choi ME, Chouaib S, Choubey D, Choubey V, Chu CT, Chuang TH, Chueh SH, Chun T, Chwae YJ, Chye ML, Ciarcia R, Ciriolo MR, Clague MJ, Clark RSB, Clarke PGH, Clarke R, Codogno P, Coller HA, Colombo MI, Comincini S, Condello M, Condorelli F, Cookson MR, Coppens GHCI, Corbalan R, Cossart P, Costelli P, Costes S, Coto-Montes A, Couve E, Coxon FP, Cregg JM, Crespo JL, Cronje MJ, Cuervo AM, Cullen JJ, Czaja MJ, D'Amelio M, rfeuille-Michaud A, Davids LM, Davies FE, De Felici M, de Groot JF, de Haan CAM, De Martino L, De Milito A, De Tata V, Debnath J, Degterev A, Dehay B, Delbridge LMD, Demarchi F, Deng YZ, Dengjel J, Dent P, Denton D, Deretic V, Desai SD, Devenish RJ, Di Gioacchino M, Di Paolo G, Di Pietro C, Diaz-Araya G, Diaz-Laviada I, Diaz-Meco MT, Diaz-Nido J, Dikic I, Dinesh-Kumar SP, Ding WX, Distelhorst CW, Diwan A, Djavaheri-Mergny M, Dokudovskaya S, Dong Z, Peters GJ, van Egmond M, et al... Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy 2012; 8: 445-544. (VUmc)

866. Kloek JJ, Maréchal X, Roelofsen J, Houtkooper RH, van Kuilenburg ABP, Kulik W, Bezemer R, Nevière R, van Gulik TM, Heger M.: Cholestasis is associated with hepatic microvascular dysfunction and aberrant energy metabolism before and during ischemia-reperfusion. Antioxidants & Redox Signaling 2012; 17(8): 1109-1123. (AMC)

867. Kluijt I, Siemerink EJ, Ausems MG, van Os TA, de Jong D, Simoes-Correia J, van Krieken JH, Ligtenberg MJ, Figueiredo J, van Riel E, Sijmons RH, Plukker JT, van Hillegersberg R, Dekker E, Oliveira C, Cats A, Hoogerbrugge N; Dutch Working Group on Hereditary Gastric Cancer. CDH1-related hereditary diffuse gastric cancer syndrome: clinical variations and implications for counseling. Int J Cancer 2012; 131: 367-76 (NKI/VUmc/AMC)

868. Kluijt I, Sijmons RH, Hoogerbrugge N, Plukker JT, de Jong D, van Krieken JH, van Hillegersberg R, Ligtenberg M, Bleiker E, Cats A. Familial gastric cancer: guidelines for diagnosis, treatment and periodic surveillance. Familial Cancer 2012; 11(3): 363-369. (AMC/NKI

869. Kluin-Nelemans HC, Hoster E, Hermine O, Walewski J, Trneny M, Geisler CH, Stilgenbauer S, Thieblemont C, Vehling-Kaiser U, Doorduijn JK, Coiffier B, Forstpointner R, Tilly H, Kanz L, Feugier P, Szymczyk M, Hallek M, Kremers S, Lepeu G, Sanhes L, Zijlstra JM, Bouabdallah R, Lugtenburg PJ, Macro M, Pfreundschuh M, Prochazka V, Di Raimondo F, Ribrag V, Uppenkamp M, Andre M, Klapper W, Hiddemann W, Unterhalt M, Dreyling MH. Treatment of Older Patients with Mantle-Cell Lymphoma. New England Journal of Medicine 2012; 367: 520-531. (VUmc)

870. Klumpers UMH, Boellaard R, Veltman DJ, Kloet RW, Hoogendijk WJG, Lammertsma AA. Parametric [C-11]flumazenil images. Nuclear Medicine Communications 2012; 33: 422-430. (VUmc)

871. Kluytmans-van den Bergh M, Kluytmans JAJW. Control of Multidrug-Resistant Microorganisms: Beyond the Hospital. Clinical Infectious Diseases 2012; 55: 1512-1514. (VUmc)

872. Kluza E, Jacobs I, Hectors SJCG, Mayo KH, Griffioen AW, Strijkers GJ, Nicolay K. Dual-targeting of alpha(v)beta(3) and galectin-1 improves the specificity of paramagnetic/fluorescent liposomes to tumor endothelium in vivo. Journal of Controlled Release 2012; 158: 207-214. (VUmc)


873. Kneepkens CMF, von Blomberg BME. Clinical practice Coeliac disease. European Journal of Pediatrics 2012; 171: 1011-1021. (VUmc)

874. Knies K, Schuster B, Ameziane N, Rooimans M, Bettecken T, de Winter J, Schindler D. Genotyping of fanconi anemia patients by whole exome sequencing: advantages and challenges. PloS one 2012; 7: e52648. (VUmc)

875. Knijnenburg S, Jaspers M, van der Pal H, Schouten-van Meeteren A, Bouts A, Lieverst J, Bökenkamp A, Koning C, Oldenburger F, Wilde J, van Leeuwen F, Caron H, Kremer L. Renal Dysfunction and Elevated Blood Pressure in Long- Term Childhood Cancer Survivors. Clinical Journal of the American Society of Nephrology 2012; 7: 1416-1427 (NKI)

876. Knijnenburg SL, Jaspers Monique W, van der Pal HJ, Schouten-van Meeteren AY, Bouts AH, Lieverst Jan A., Bökenkamp Arend, Koning Caro C. E., Oldenburger Foppe, Wilde James C. H., van Leeuwen Flora E., Caron Huib N., Kremer Leontien C.: Renal dysfunction and elevated blood pressure in long-term childhood cancer survivors. CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY 7(9), 2012, p.1416-1427.

877. Knoop J, van der Leeden M, van der Esch M, Thorstensson CA, Gerritsen M, Voorneman RE, Lems WF, Roorda LD, Dekker J, Steultjens MPM. Association of lower muscle strength with self-reported knee instability in osteoarthritis of the knee: Results from the Amsterdam Osteoarthritis Cohort. Arthritis Care & Research 2012; 64: 38-45. (VUmc)

878. Knops RE, Kooiman KM, ten Sande JN, de Groot JR, Wilde AAM. First experience with the wearable cardioverter defibrillator in the Netherlands. Netherlands Heart Journal 2012; 20(2): 77-81. (AMC)

879. Knops RRG, Hulscher MEJL, Hermens RPMG, Hilbink-Smolders M, Loeffen JL, Kollen WJW, Kaspers GJL, Caron HN, Kremer LCM. High-quality care for all children with cancer. Annals Of Oncology 2012; 23(7): 1906-1911. (AMC/Vumc)

880. Kobayashi KS, van den Elsen PJ. NLRC5: a key regulator of MHC class I-dependent immune responses. Nature Reviews Immunology 2012; 12: 813-820. (VUmc)

881. Kobe C, Scheffler M, Holstein A, Zander T, Nogova L, Lammertsma AA, Boellaard R, Neumaier B, Ullrich RT, Dietlein M, Wolf J, Kahraman D. Predictive value of early and late residual F-18-fluorodeoxyglucose and F-18-fluorothymidine uptake using different SUV measurements in patients with non-small-cell lung cancer treated with erlotinib. European Journal of Nuclear Medicine and Molecular Imaging 2012; 39: 1117-1127. (VUmc)

882. Kocemba KA, Groen RWJ, van Andel H, Kersten MJ, Mahtouk K, Spaargaren M, Pals ST. Transcriptional silencing of the Wnt-antagonist DKK1 by promoter methylation is associated with enhanced Wnt signaling in advanced multiple myeloma. Plos One 2012; 7(2): e30359-. (AMC)

883. Kocken M, Berkhof J, van Kemenade FJ, Louwers JA, Zaal A, Nobbenhuis MA, Kenter G, Snijders PJ, Meijer CJ, Helmerhorst TJ. Long-term CIN3+ risk in women with abnormal cytology; role of hrHPV testing. Br J Cancer 2012; 106: 817-25 (NKI/Vumc)

884. Kocken M, Uijterwaal MH, de Vries ALM, Berkhof J, Ket JCF, Helmerhorst TJM, Meijer CJLM. High-risk human papillomavirus testing versus cytology in predicting post-treatment disease in women treated for high-grade cervical disease: A systematic review and meta-analysis. Gynecol Oncol 2012; 125: 500-507. (VUmc)

885. Koedooder C, Dinkla A, Pieters B, van Wieringen N, van der Laarse R, van der Grient J, Bel A. SU-E-T-326: Repeated CT-Scans in Pulsed Doserate Prostate Brachytherapy: Assessment of Deviations from the Treatment Plan. Medical Physics 2012; 39(6): 3779-. (AMC)

886. Koedooder C, Rijnders A, Aalbers A, de Brabandere M, Moerland M, Schaeken R, Thissen B, van 't Riet A, Vynckier S. SU-C-BRCD-03: Recommendations for Quality Control of Prostate Brachytherapy with I-125 Seeds, Based on a Survey of Current Practice in the Netherlands and Belgium. Medical Physics 2012; 39(6): 3600-. (AMC)

887. Koelewijn WT, Ehrenhard ML, Groen AJ, Van Harten WH Intraorganizational dynamics as drivers of entrepreneurschip among physicians and managers in hospitals of western countries. Soc Sci Med 2012; 75: 795- 800 (NKI)

888. Kok M, Koornstra RH, Mook S, Hauptmann M, Fles R, Jansen MP, Berns EM, Linn SC, Van ‘t Veer LJ. Additional value of the 70-gene signature and levels of ER and PR for the prediction of outcome in tamoxifentreated ER-positive breast cancer. Breast 2012; 21: 769-78 (NKI)

889. Kolfschoten NE, Gooiker GA, Bastiaannet E, van Leersum NJ, van de Velde CJH, Eddes EH, Marang-van de Mheen PJ, Kievit J, van der Harst E, Wiggers T, Wouters MWJM, Tollenaar RAEM. Combining process indicators to evaluate quality of care for surgical patients with colorectal cancer: are scores consistent with short-term outcome? BMJ Quality & Safety 2012; 21(6): 481-489. (AMC)

890. Kong FM, Ritter T, Quint D, Marsh L, Senan S, Gaspar L, Komaki R, Hurkmans C, Timmerman R, Choy H, Bezjak A, Bradley J, Mosvas B, Okunieff P, Curran W. Oncology Scan - Gastrointestinal Cancer Reply. International Journal of Radiation Oncology Biology Physics 2012; 84: 305-306. (VUmc)

891. Konge L, Vilmann P, Clementsen P, Annema JT, Ringsted C. Reliable and valid assessment of competence in endoscopic ultrasonography and fine-needle aspiration for mediastinal staging of non-small cell lung cancer. Endoscopy 2012; 44(10): 928-933. (AMC)

892. Koning CC, Blank LE, Koedooder C, van Os RM, van de Kar M, Jansen E, Battermann JJ, Beijert M, Gernaat C, van Herpen KA, Hoekstra C, Horenblas S, Jobsen JJ, Krol AD, Lybeert ML, van Onna IE, Pelger RC, Poortmans P, Pos FJ, van der Steen-Banasik E, Slot A, Visser A, Pieters BR. Brachytherapy after external beam radiotherapy and limited surgery preserves bladders for patients with solitary pT1-pT3 bladder tumors. Ann Oncol 2012; 23: 2948-53 (AMC/NKI)

893. Koning CCE, Aarts MJ, Struikmans H, Poortmans PMP, Lybeert MLM, Jobsen JJ, Coebergh JWW, Janssen-Heijnen MLG, Visser O, Louwman WJ, Burgers JA. Mapping use of radiotherapy for patients with non-small cell lung cancer in the Netherlands between 1997 and 2008. Clinical Oncology 2012; 24(2): e46-e53. (AMC)

894. Koning CCE, Nortier JWRH. Herbestraling van pijnlijke botmetastasen: te weinig kennis over effect. Nederlands Tijdschrift Voor Geneeskunde 2012; 156(41): A5296-. (AMC)

895. Koning JJ, Mebius RE. Interdependence of stromal and immune cells for lymph node function. Trends in Immunology 2012; 33: 264-270. (VUmc)

896. Koningstein M, Groen L, Geraats/Peters K, Lutgens S, Rietveld A, Jira P, Kluytmans J, de Greeff SC, Hermans M, Schneeberger PM. The use of typing methods and infection prevention measures to control a bullous impetigo outbreak on a neonatal ward. Antimicrob Resist Infect Control 2012; 1: 37. (VUmc)

897. Kool M, Korshunov A, Remke M, Jones DTW, Schlanstein M, Northcott PA, Cho YJ, Koster J, Schouten-van Meeteren A, van Vuurden D, Clifford SC, Pietsch T, von Bueren AO, Rutkowski S, McCabe M, Collins VP, Bäcklund ML, Haberler C, Bourdeaut F, Delattre O, Doz F, Ellison DW, Gilbertson RJ, Pomeroy SL, Taylor MD, Lichter P, Pfister SM. Molecular subgroups of medulloblastoma: an international meta-analysis of transcriptome, genetic aberrations, and clinical data of WNT, SHH, Group 3, and Group 4 medulloblastomas. Acta Neuropathologica 2012; 123(4): 473-484. (AMC/VUmc)


898. Koolen BB, Valdés Olmos RA, Elkhuizen PHM, Vogel WV, Vrancken Peeters MJTFD, Rodenhuis S, Rutgers EJT, Locoregional lymph node involvement on 18F-FDG PET/CT in breast cancer patients scheduled for neoadjuvant chemotherapy. Breast Cancer Res Treat 2012; 135: 231-40 (NKI)

899. Koolen BB, Vegt E, Rutgers EJ, Vogel WV, Stokkel MP, Hoefnagel CA, Fioole- Bruining A, Vrancken Peeters MJ, Valdés Olmos RA. FDG-avid sclerotic bone metastases in breast cancer patients: a PET/CT case series. Ann Nucl Med 2012; 26: 86-91 (NKI)

900. Koolen BB, Vogel WV, Vrancken Peeters MJTFD, Loo CE, Rutgers EJT, Valdés Olmos RA Molecular imaging in breast cancer: from whole body PET/ CT to dedicated breast PET J Oncol 2012; 2012: 438647 (NKI)

901. Koolen BB, Vrancken Peeters MJTFD, Aukema TS, Vogel WV, Oldenburg HSA, van der Hage JA, Hoefnagel CA, Stokkel MPM, Loo CE, Rodenhuis S, Rutgers EJT, Valdés Olmos RA, 18F-FDG PET/CT as a staging procedure in primary stage II and III breast cancer: comparison with conventional imaging techniques. Breast Cancer Res Treat 2012; 131: 117-26 (NKI)

902. Koolen BB, Vrancken Peeters MJTFD, Wesseling J, Lips EH, Vogel WV, Aukema TS, van Werkhoven E, Gilhuijs KGA, Rodenhuis S, Rutgers EJT, Valdés Olmos RA, Association of primary tumour FDG uptake with clinical, histopathological, and molecular characteristics in breast cancer patients scheduled for neoadjuvant chemotherapy. Eur J Nucl Med Mol Imaging 2012; 37: 1830-8 (NKI)

903. Koolen SL, van Waterschoot RA, van Tellingen O, Schinkel AH, Beijnen JH, Schellens JH, Huitema AD. From mouse to man: predictions of human pharmacokinetics of orally administered docetaxel from preclinical studies. J Clin Pharmacol 2012; 52: 370- 80 (NKI)

904. Koppelmans V, Breteler MM, Boogerd W, Seynaeve C, Gundy C, Schagen SB. Neuropsychological performance in survivors of breast cancer more than 20 years after adjuvant chemotherapy. J Clin Oncol 2012; 1; 30: 1080-6 (NKI)

905. Koppelmans V, de Ruiter MB, van der Lijn F, Boogerd W, Seynaeve C, van der Lugt A, Vrooman H, Niessen WJ, Breteler MM, Schagen SB. Global and focal brain volume in long-term breast cancer survivors exposed to adjuvant chemotherapy. Breast Cancer Res Treat 2012; 132: 1099-106 (NKI)

906. Korkmaz G, le Sage C, Tekirdag KA, Agami R and Gozuacik D. miR- 376b controls starvation and mTOR inhibition-related autophagy by targeting ATG4C and BECN1. Autophagy 2012; 8: 165-176 (NKI)

907. Korse CM, Taal BG, Vincent A, van Velthuysen ML, Baas P, Buning-Kager JC, Linders TC, Bonfrer JM. Choice of tumour markers in patients with neuroendocrine tumours is dependent on the histological grade. A marker study of Chromogranin A, Neuron specific enolase, Progastrin-releasing peptide and cytokeratin fragments. Eur J Cancer 2012; 48: 662-71 (NKI)

908. Korshunov A, Ryzhova M, Jones DTW, Northcott PA, van Sluis P, Volckmann R, Koster J, Versteeg R, Cowdrey C, Perry A, Picard D, Rosenblum M, Giangaspero F, Aronica E, Schüller U, Hasselblatt M, Collins VP, von Deimling A, Lichter P, Huang A, Pfister SM, Kool M. LIN28A immunoreactivity is a potent diagnostic marker of embryonal tumor with multilayered rosettes (ETMR). Acta Neuropathologica 2012; 124(6): 875-881. (AMC)

909. Korsse SE, Dewint P, Kuipers EJ, van Leerdam ME. Small bowel endoscopy and Peutz-Jeghers syndrome. Best Pract Res Clin Gastroenterol 2012; 26: 263-78 (NKI)

910. Kortram K, van Ramshorst B, Bollen TL, Besselink MGH, Gouma DJ, Karsten T, Kruyt PM, Nieuwenhuijzen GAP, Kelder JC, Tromp E, Boerma D. Acute cholecystitis in high risk surgical patients: percutaneous cholecystostomy versus laparoscopic cholecystectomy (CHOCOLATE trial): study protocol for a randomized controlled trial. Trials 2012; 13(1): p.7-. (AMC)

911. Koster GT, Brandsma D, Boot H, Kruyt ND. Multiple cerebral air emboli during upper gastrointestinal endoscopy. J Neurol Neurosurg Psychiatry 2012; 83: 1110-1 (NKI)

912. Kraan CTMV, Baggen JM, van Bodegraven AA, Mulder CJJ, Zwiers A, Geerts D, Kraal G, Horrevoets AJ, Bouma G. Defective IL-1A expression in patients with Crohn's disease is related to attenuated MAP3K4 signaling. Human Immunology 2012; 73: 912-919. (VUmc)

913. Kracht PAM, Sigurdsson V, Hoogewerf M, Arends JE. A leg with an ulcer. Netherlands Journal of Medicine 2012; 70: 85-+. (VUmc)

914. Kraeber-Bodéré F, Carlier T, Naegelen VM, Shochat E, Lumbroso J, Trampal C, Nagarajah J, Chua S, Hugonnet F, Stokkel M, Gleeson F, Tessier J. Differences in the Biologic Activity of 2 Novel MEK Inhibitors Revealed by 18F-FDG PET: Analysis of Imaging Data from 2 Phase I Trials. J Nucl Med 2012; 53: 1836-1846 (NKI)

915. Kragelund C, Reibel J, Hietanen J, Hadler-Olsen E, Johannessen AC, Kenrad B, Nylander K, Puranen M, Salo T, Syrjanen S, Soland TM, van der Waal I, van der Wal JE, Warfvinge G. Scandinavian Fellowship for Oral Pathology and Oral Medicine: guidelines for oral pathology and oral medicine in the dental curriculum. European Journal of Dental Education 2012; 16: 246-253. (VUmc)

916. Kramer G, Moerland PD, Jeeninga RE, Vlietstra WJ, Ringrose JH, Byrman C, Berkhout B, Speijer D. Proteomic analysis of HIV-T cell interaction: an update. Frontiers In Microbiology 2012; 3: 240-(6 p.). (AMC)

917. Kranenburg O, Emmink BL, Knol J, van Houdt WJ, Rinkes IHMB, Jimenez CR. Proteomics in studying cancer stem cell biology. Expert Review of Proteomics 2012; 9: 325-336. (VUmc)

918. Krawczyk PM, Borovski T, Stap J, Cijsouw T, ten Cate R, Medema JP, Kanaar R, Franken NAP, Aten JA. Chromatin mobility is increased at sites of DNA double-strand breaks. Journal Of Cell Science 2012; 125(Part 9): 2127-2133. (AMC)

919. Krebber AMH, Leemans CR, de Bree R, van Straten A, Smit F, Smit EF, Becker A, Eeckhout GM, Beekman ATF, Cuijpers P, Verdonck-de Leeuw IM. Stepped care targeting psychological distress in head and neck and lung cancer patients: a randomized clinical trial. BMC Cancer 2012; 12: . (VUmc)

920. Kreeft AM, Krap M, Wismeijer D, Speksnijder CM, Smeele LE, Bosch SD, Muijen MS, Balm AJM. Oral function after maxillectomy and reconstruction with an obturator. Int J Oral Maxillofac Surg 2012; 41: 1387-92 (NKI)

921. Kreeft AM, Rasch CR, Muller SH, Pameijer FA, Hallo E, Balm AJM. Cine MRI of swallowing in patients with advanced oral or oropharyngeal carcinoma: a feasibility study. Eur Arch Otorhinolaryngol 2012; 269: 1703-11 (NKI/AMC)

922. Kreeft AM, Smeele LE, Rasch CR, Hauptmann M, Rietveld DH, Leemans CR, Balm AJ. Preoperative imaging and surgical margins in maxillectomy patients. Head Neck 2012; 34: 1652-6 (NKI/AMC/VUmc)

923. Krekel NMA, Haloua MH, Meijer S, van den Tol MP. Response to "A comparison of three methods for nonpalpable breast cancer excision". European Journal of Surgical Oncology 2012; 38: 1236-1237. (VUmc)

924. Krekel NMA, van Slooten HJ, Barbe E, de Klerk ESMD, Meijer S, van den Tol MP. Is breast specimen shrinkage really a problem in breast-conserving surgery?. Journal of Clinical Pathology 2012; 65: 224-227. (VUmc)


925. Krieckaert CL, Jamnitski A, Nurmohamed MT, Kostense PJ, Boers M, Wolbink G. Comparison of Long-Term Clinical Outcome With Etanercept Treatment and Adalimumab Treatment of Rheumatoid Arthritis With Respect to Immunogenicity. Arthritis and Rheumatism 2012; 64: 3850-3855. (VUmc)

926. Krieckaert CL, Lems WF. Biologicals and bone loss. Thera Adv Musculoskeletal Dis 2012; 4: 245-247. (VUmc) 927. Krijgsman O, Israeli D, Haan JC, van Essen HF, Smeets SJ, Eijk PP, Steenbergen RDM, Kok K, Tejpar S, Meijer GA,

Ylstra B. CGH arrays compared for DNA isolated from formalin-fixed, paraffin-embedded material. Genes Chromosomes & Cancer 2012; 51: 344-352. (VUmc)

928. Krijgsman O, Roepman P, Zwart W, Carroll JS, Tian S, de Snoo FA, Bender RA, Bernards R, Glas AM. A diagnostic gene profile for molecular subtyping of breast cancer associated with treatment response. Breast Cancer Res Treat 2012; 133: 37-47 (NKI)

929. Krimpenfort K, Song JY, Proost N, Zevenhoven J, Jonkers J, Berns A. Deleted in Colorectal Carcinoma (DCC) suppresses metastasis formation in p53 deficient mammary tumors. Nature 2012; 482: 538-41 (NKI)

930. Kroeze KL, Boink MA, Sampat-Sardjoepersad SC, Waaijman T, Scheper RJ, Gibbs S. Autocrine Regulation of Re-Epithelialization After Wounding by Chemokine Receptors CCR1, CCR10, CXCR1, CXCR2, and CXCR3. Journal of Investigative Dermatology 2012; 132: 216-225. (VUmc)

931. Kroeze KL, Vink L, de Boer EM, Scheper RJ, van Montfrans C, Gibbs S. Simple wound exudate collection method identifies bioactive cytokines and chemokines in (arterio) venous ulcers. Wound Repair and Regeneration 2012; 20: 294-303. (VUmc)

932. Kroon BBR. Surgery for distant metastatic melanoma improves survival. Ann Surg Oncol 2012; 19: 2426-7 (NKI) 933. Kroon MW, Joore ICKW, Wind BS, Leloup MAC, Wolkerstorfer A, Luiten RM, Bos JD, Geskus RB, van der Veen JPW. Low

yield of routine screening for thyroid dysfunction in asymptomatic patients with vitiligo. British Journal Of Dermatology 2012; 166(3): 532-538. (AMC)

934. Kroon MW, Wind BS, Meesters AA, Wolkerstorfer A, van der Veen JPW, Bos JD, van der Wal AC, Beek JF. Non-ablative 1550 nm fractional laser therapy not effective for erythema dyschromicum perstans and postinflammatory hyperpigmentation: a pilot study. Journal Of Dermatological Treatment 2012; 23(5): 339-344. (AMC)

935. Krumpochova P, Sapthu S, Brouwers JF, de Haas M, de Vos R, Borst P, van de Wetering K: Transportomics: screening for substrates of ABC transporters in body fluids using vesicular transport assays. Faseb Journal 2012; 26(2): 738-747. (AMC/NKI)

936. Kubal TE, Spiess PhE, Bergman AM. Essentials and Updates in Urologic Oncology (Eds Ph. E. Spiess). Chapter 31: Management of advanced penile cancer (NKI)

937. Kubben N, Adriaens M, Meuleman W, Voncken JW, van Steensel B, Misteli T. Mapping of lamin A- and progerin-interacting genome regions. Chromosoma 2012; 121: 447-64 (NKI)

938. Kuijk LM, Klaver EJ, Kooij G, van der Pol SMA, Heijnen P, Bruijns SCM, Kringel H, Pinelli E, Kraal G, de Vries HE, Dijkstra CD, Bouma G, van Die I. Soluble helminth products suppress clinical signs in murine experimental autoimmune encephalomyelitis and differentially modulate human dendritic cell activation. Molecular Immunology 2012; 51: 210-218. (VUmc)

939. Kuijl C, Pilli M, Alahari SK, Janssen H, Khoo P-S, Ervin KE, Calero M, Jonnalagadda S, Scheller RH, Neefjes J and Junutula JR. Rac and Rab GTPases Dual effector Nischarin facilitates vesicle maturation and survival of intracellular Salmonella typhimurium. EMBO J. 2013; 110: 175-180 (NKI)

940. Kuiken HJ, Egan DA, Laman H, Bernards R, Beijersbergen RL, Dirac AM. Identification of F-box only protein 7 as a negative regulator of NF-kappaB signalling. J Cell Mol Med 2012; 16: 2140-9 (NKI)

941. Kuiper JL, Lind JSW, Groen HJM, Roder J, Grigorieva J, Roder H, Dingemans AMC, Smit EF. VeriStrat (R) has prognostic value in advanced stage NSCLC patients treated with erlotinib and sorafenib. Br J Cancer 2012; 107: 1820-1825. (VUmc)

942. Kuiper T, Kiesslich R, Ponsioen C, Fockens P, Dekker E. The learning curve, accuracy, and interobserver agreement of endoscope-based confocal laser endomicroscopy for the differentiation of colorectal lesions. Gastrointestinal Endoscopy 2012; 75(6): 1211-1217. (AMC)

943. Kuiper T, Marsman WA, Jansen JM, van Soest EJ, Haan YCL, Bakker GJ, Fockens P, Dekker E. Accuracy for optical diagnosis of small colorectal polyps in nonacademic settings. Clinical Gastroenterology And Hepatology 2012; 10(9): 1016-20; quiz e79. (AMC)

944. Kuiper T, van den Broek FJC, van Eeden S, Fockens P, Dekker E. Feasibility and Accuracy of Confocal Endomicroscopy in Comparison With Narrow-Band Imaging and Chromoendoscopy for the Differentiation of Colorectal Lesions. American Journal Of Gastroenterology 2012; 107(4): 543-550. (AMC)

945. Kuiper T, Vlug MS, van den Broek FJC, Tytgat KMAJ, van Eeden S, Fockens P, Bemelman WA, Dekker E. The prevalence of dysplasia in the ileoanal pouch following restorative proctocolectomy for ulcerative colitis with associated dysplasia. Colorectal Disease 2012; 14(4): 469-473. (AMC)

946. Kumamaru H, Saiwai H, Kobayakawa K, Kubota K, Van Rooijen N, Inoue K, Iwamoto Y, Okada S. Liposomal clodronate selectively eliminates microglia from primary astrocyte cultures. Journal of Neuroinflammation 2012; 9: . (VUmc)

947. Kvistborg P, Shu CJ, Heemskerk B, Fankhauser M, Thrue CA, Toebes M, van Rooij N, Linnemann C, van Buuren MM, Urbanus JH, Beltman JB, Thor Straten P, Li YF, Robbins PF, Besser MJ, Schachter J, Kenter GG, Dudley ME, Rosenberg SA, Haanen JB, Hadrup SR, Schumacher TN. TIL therapy broadens the tumor-reactive CD8(+) T cell compartment in melanoma patients. Oncoimmunology 2012; 1: 409-18 (NKI/VUmc)

948. Kwakernaak AJ, Hazenberg MD, Roelofs JJ, van Noesel CJ, van Oers MH, van Tellingen A. T-lymfoblastair lymfoom zich presenterend als primair renaal lymfoom met acute nierinsufficiëntie. nederlands tijdschrift voor hematologie 2012; 9: 34-. (AMC)

949. Kwint M, Uyterlinde W, Nijkamp J, Chen C, de Bois J, Sonke JJ, van den Heuvel M, Knegjens J, van Herk M, Belderbos J. Acute esophagus toxicity in lung cancer patients after intensity modulated radiation therapy and concurrent chemotherapy. Int J Radiat Oncol Biol Phys 2012; 84: e223-8 (NKI)

950. la Porta MG, Picone C, Pascutto C, Malcovati L, Tamura H, Handa H, Czader M, Freeman S, Vyas P, Porwit A, Saft L, Westers TM, Alhan C, Cali C, van de Loosdrecht AA, Ogata K. Multicenter validation of a reproducible flow cytometric score for the diagnosis of low-grade myelodysplastic syndromes: results of a European LeukemiaNET study. Haematologica-The Hematology Journal 2012; 97: 1209-1217. (VUmc)

951. Lagas JS, Damen CW, van Waterschoot RA, Iusuf D, Beijnen JH, Schinkel AH. P-gp, Mrp2, Cyp3a, and carboxylesterase affect the oral availability and metabolism of vinorelbine. Mol Pharmacol 2012; 82: 636-44 (NKI)


952. Lagerwaard FJ, Aaronson NK, Gundy CM, Cornelis JA, Slotman BJ, Senan S. Patient-reported quality of life after stereotactic ablative radiotherapy for early stage lung cancer. J Thorac Oncol 2012; 7: 1148-54 (Vumc/NKI)

953. Lagerwaard FJ, Verstegen NE, Haasbeek CJA, Slotman BJ, Paul MA, Smit EF, Senan S. Outcomes of Stereotactic Ablative Radiotherapy in Patients With Potentially Operable Stage I Non-Small Cell Lung Cancer. International Journal of Radiation Oncology Biology Physics 2012; 83: 348-353. (VUmc)

954. Lai SL, Yao WL, Tsao KC, Houben AJ, Albers HM, Ovaa H, Moolenaar WH, Lee SJ. Autotaxin/Lpar3 signaling regulates Kupffer’s vesicle formation and left-right asymmetry in zebrafish. Development 2012; 139: 4439-48 (NKI)

955. Laitman Y, Kuchenbaecker KB, Rantala J, Hogervorst F, Peock S, Godwin AK, Arason A, Kirchhoff T, Offit K, Isaacs C, Schmutzler RK, Wappenschmidt B, Nevanlinna H, Chen X, Chenevix-Trench G, Healey S, Couch F, Peterlongo P, Radice P, Nathanson KL, Caligo MA, Neuhausen SL, Ganz P, Sinilnikova OM, McGuffog L, Easton DF, Antoniou AC, Wolf I, Friedman E. The KL-VS sequence variant of Klotho and cancer risk in BRCA1 and BRCA2 mutation carriers. Breast Cancer Res Treat 2012; 132: 1119-1126 (NKI)

956. Lam SW, Leenen LPH, van Solinge WW, Hietbrink F, Huisman A. Comparison between the prognostic value of the white blood cell differential count and morphological parameters of neutrophils and lymphocytes in severely injured patients for 7-day in-hospital mortality. Biomarkers 2012; 17: 642-647. (VUmc)

957. Lam TJ, Felt-Bersma RJF. A novel device reduces anal pain after rubber band ligation: a randomized controlled trial. Techniques in Coloproctology 2012; 16: 221-226. (VUmc)

958. Lam TJ, Kuik DJ, Felt-Bersma RJF. Anorectal function evaluation and predictive factors for faecal incontinence in 600 patients. Colorectal Disease 2012; 14: 214-223. (VUmc)

959. Lam TJ, Mulder CJJ, Felt-Bersma RJF. Critical reappraisal of anorectal function tests in patients with faecal incontinence who have failed conservative treatment. International Journal of Colorectal Disease 2012; 27: 931-937. (VUmc)

960. Lambin P, Rios-Velazquez E, Leijenaar R, Carvalho S, van Stiphout RGPM, Granton P, Zegers CML, Gillies R, Boellard R, Dekker A, Aerts HJWL. Radiomics: Extracting more information from medical images using advanced feature analysis. European Journal of Cancer 2012; 48: 441-446. (VUmc)

961. Lambrechts D, Truong T, Justenhoven C et al. 11q13 is a Susceptibility Locus for Hormone Receptor Positive Breast Cancer. Hum Mutat 2012; 33: 1123-32 (NKI)

962. Lamers F, Schild L, den Hartog IJM, Ebus ME, Westerhout EM, Ora I, Koster J, Versteeg R, Caron HN, Molenaar JJ. Targeted BCL2 inhibition effectively inhibits neuroblastoma tumour growth. European Journal Of Cancer 2012; 48(16): 3093-3103. (AMC)

963. Lamers F, Schild L, Koster J, Speleman F, Ora I, Westerhout EM, van Sluis P, Versteeg R, Caron HN, Molenaar JJ. Identification of BIRC6 as a novel intervention target for neuroblastoma therapy. BMC Cancer 2012; 12(1): 285-. (AMC)

964. Lamers F, Schild L, Koster J, Versteeg R, Caron HN, Molenaar JJ. Targeted BIRC5 silencing using YM155 causes cell death in neuroblastoma cells with low ABCB1 expression. European Journal Of Cancer 2012; 48(5): 763-771. (AMC)

965. Lammers AJJ, de Porto APNA, Bennink RJ, van Leeuwen EMM, Biemond BJ, Goslings JC, van Marle J, ten Berge IJM, Speelman P, Hoekstra JBL. Hyposplenism: comparison of different methods for determining splenic function. American Journal Of Hematology 2012; 87(5): 484-489. (AMC)

966. Landoni VI, Chiarella P, Martire-Greco D, Schierloh P, Van Rooijen N, Rearte B, Palermo MS, Isturiz MA, Fernandez GC. Tolerance to lipopolysaccharide promotes an enhanced neutrophil extracellular traps formation leading to a more efficient bacterial clearance in mice. Clin Exp Immunol 2012; 168: 153-163. (VUmc)

967. Langerak AW, Groenen PJTA, Brüggemann M, Beldjord K, Bellan C, Bonello L, Boone E, Carter GI, Catherwood M, Davi F, Delfau-Larue MH, Diss T, Evans PAS, Gameiro P, Garcia Sanz R, Gonzalez D, Grand D, Håkansson A, Hummel M, Liu H, Lombardia L, Macintyre EA, Milner BJ, Montes-Moreno S, Schuuring E, Spaargaren M, Hodges E, van Dongen JJM. EuroClonality/BIOMED-2 guidelines for interpretation and reporting of Ig/TCR clonality testing in suspected lymphoproliferations. Leukemia 2012; 26(10): 2159-2171. (AMC)

968. Langeveld D, Jansen M, de Boer DV, van Sprundel M, Brosens LAA, Morsink FH, Giardiello FM, Offerhaus GJA, de Leng WWJ. Aberrant intestinal stem cell lineage dynamics in Peutz-Jeghers syndrome and familial adenomatous polyposis consistent with protracted clonal evolution in the crypt. GUT 2012; 61(6): 839-846. (AMC)

969. Langius JAE, Kruizenga HM, Uitdehaag BMJ, Langendijk JA, Doornaert P, Leemans CR, Weijs PJM. Resting energy expenditure in head and neck cancer patients before and during radiotherapy. Clinical Nutrition 2012; 31: 549-554. (VUmc)

970. Lankheet N, Schaake E, Rosing H, Burgers J, Schellens J, Beijnen J, Huitema A. Quantitative determination of erlotinib and O-desmethyl erlotinib in human EDTA plasma and lung tumor tissue. Bioanalysis 2012; 4: 2563-77 (NKI)

971. Lapid O, van der Horst CM, Kater AP. Donor-derived fat tissue as a source for lipofilling after allogeneic hematopoietic cell transplantation. Journal Of Clinical Oncology 2012; 30(17): e154-e155. (AMC)

972. Lascano V, Zabalegui LF, Cameron K, Guadagnoli M, Jansen M, Burggraaf M, Versloot M, Rodermond H, van der Loos C, Carvalho-Pinto CE, Kalthoff H, Medema JP, Hahne M. The TNF family member APRIL promotes colorectal tumorigenesis. Cell Death And Differentiation 2012; 19(11): 1826-1835. (AMC)

973. Lauw MN, Bus EWN, van Wulfften Palthe AFY, Coppens M, Homburg CH, Middeldorp S, van der Schoot CE, Koene HR, Biemond BJ. Relevance of the JAK2V617F mutation in patients with deep vein thrombosis of the leg. Annals Of Hematology 2012; 91(1): 103-107. (AMC)

974. le Coutre P, Giles F, Hochhaus A, Apperley J, Ossenkoppele G, Blakesley R, Shou Y, Gallagher N, Baccarani M, Cortes J, Kantarjian H. Nilotinib in patients with Ph+ chronic myeloid leukemia in accelerated phase following imatinib resistance or intolerance: 24-month follow-up results. Leukemia 2012; 26: 1189-1194. (VUmc)

975. le Poole CY, Welten AGA, ter Wee PM, Paauw NJ, Djorai AN, Valentijn RM, Beelen RHJ, van den Born J, van Ittersum FJ. A Peritoneal Dialysis Regimen Low in Glucose and Glucose Degradation Products Results in Increased Cancer Antigen 125 and Peritoneal Activation. Peritoneal Dialysis International 2012; 32: 305-315. (VUmc)

976. Lebre MC, Jonckheere CL, Kraan MC, van Kuijk AWR, Bos JD, de Rie M, Gerlag DM, Tak PP. Expression of Il-20 in Lesional Skin and Synovium of Patients with Psoriatic Arthritis Compared to Rheumatoid Arthritis and Its Response to Alefacept Treatment. Annals of the Rheumatic Diseases 2012; 71: A15. (VUmc)

977. Lee JH, Giovannetti E, Hwang JH, Petrini I, Wang QY, Voortman J, Wang YH, Steinberg SM, Funel N, Meltzer PS, Wang YS, Giaccone G. Loss of 18q22.3 Involving the Carboxypeptidase of Glutamate-like Gene Is Associated with Poor Prognosis in Resected Pancreatic Cancer. Clin Cancer Res 2012; 18: 524-533. (VUmc)

978. Leenders MWH, Broeders M, Croese C, Richir MC, Go HLS, Langenhorst BLAM, Meijer S, Schreurs WH. Ultrasound and fine needle aspiration cytology of axillary in breast cancer. To do or not to do?. Breast 2012; 21: 578-583. (VUmc)


979. Leenen CH, van Lier MG, van Doorn HC, van Leerdam ME, Kooi SG, de Waard J, Hoedemaeker RF, van den Ouweland AM, Hulspas SM, Dubbink HJ, Kuipers EJ, Wagner A, Dinjens WN, Steyerberg EW. Prospective evaluation of molecular screening for Lynch syndrome in patients with endometrial cancer ≤ 70 years. Gynecol Oncol 2012; 125: 414-20 (NKI)

980. Leijen S, Middleton MR, Tresca P, Kraeber-Bodéré F, Dieras V, Scheulen ME, Gupta A, Lopez-Valverde V, Xu ZX, Rueger R, Tessier JJ, Shochat E, Blotner S, Naegelen VM, Schellens JH, Eberhardt WE. Phase I dose-escalation study of the safety, pharmacokinetics, and pharmacodynamics of the MEK inhibitor RO4987655 (CH4987655) in patients with advanced solid tumors. Clin Cancer Res 2012; 18: 4794-805 (NKI)

981. Leusink FKJ, Van Es RJJ, de Bree R, de Jong RJB, van Hooff SR, Holstege FCP, Slootweg PJ, Brakenhoff RH, Takes RP. Novel diagnostic modalities for assessment of the clinically node-negative neck in oral squamous-cell carcinoma. Lancet Oncology 2012; 13: E554-E561. (VUmc)

982. Li JA, de Groot M, Helderman F, Mo JH, Daniels JMA, Grunberg K, Sutedja TG, de Boer JF. High speed miniature motorized endoscopic probe for optical frequency domain imaging. Optics Express 2012; 20: 24132-24138. (VUmc)

983. Limonard EJ, Bisschop PH, Fliers E, Nieveen van Dijkum EJ. Thyroid function after subtotal thyroidectomy in patients with Graves' hyperthyroidism. Thescientificworldjournal 2012; 2012: 548796-5. (AMC)

984. Limper M, van de Stadt L, Bos W, de Kruif M, Spek A, Wolbink G, van Schaardenburg D, van Gorp E. The Acute-phase Response Is Not Predictive for the Development of Arthritis in Seropositive Arthralgia - A Prospective Cohort Study. Journal Of Rheumatology 2012; 39(10): 1914-1917. (AMC/Vumc)

985. Lin F, Chandrasekaran G, de Gooijer MC, Beijnen JH, van Tellingen O. Determination of NVP-BEZ235, a dual PI3K and mTOR inhibitor, in human and mouse plasma and in mouse tissue homogenates by reversed-phase highperformance liquid chromatography with fluorescence detection. J Chromatogr B Analyt Technol Biomed Life Sci 2012; 901: 9-17 (NKI)

986. Lind JSW, Senan S, Smit EF. Pulmonary Toxicity After Bevacizumab and Concurrent Thoracic Radiotherapy Observed in a Phase I Study for Inoperable Stage III Non-Small-Cell Lung Cancer. J Clin Oncol 2012; 30: E104-E108. (VUmc)

987. Linde N, Lederle W, Depner S, Van Rooijen N, Gutschalk CM, Mueller MM. Vascular endothelial growth factor-induced skin carcinogenesis depends on recruitment and alternative activation of macrophages. Journal of Pathology 2012; 227: 17-28. (VUmc)

988. Linn AJ, van Weert JCM, Schouten BC, Smit EG, van Bodegraven AA, van Dijk L. Words that make pills easier to swallow: a communication typology to address practical and perceptual barriers to medication intake behavior. Patient Preference and Adherence 2012; 6: . (VUmc)

989. Linthorst Homan MW, Spuls PI, Nieuweboer-Krobotova L, de Korte J, Sprangers MAG, Bos JD, Wolkerstorfer A, van der Veen JPW. A randomized comparison of excimer laser versus narrow-band ultraviolet B phototherapy after punch grafting in stable vitiligo patients. Journal Of The European Academy Of Dermatology And Venereology 2012; 26(6): 690-695. (AMC)

990. Lipham JC, DeMeester TR, Ganz RA, Bonavina L, Saino G, Dunn DH, Fockens P, Bemelman W. The LINX® reflux management system: confirmed safety and efficacy now at 4 years. Surgical Endoscopy And Other Interventional Techniques 2012; 26(10): 2944-2949. (AMC)

991. Lips EH, Mukhtar RA, Yau C, de Ronde JJ, Livasy C, Carey LA, Loo CE, Vrancken-Peeters MJ, Sonke GS, Berry DA, Van't Veer LJ, Esserman LJ, Wesseling J, Rodenhuis S, Shelley Hwang E; I-SPY TRIAL Investigators. Lobular histology and response to neoadjuvant chemotherapy in invasive breast cancer. Breast Cancer Res Treat 2012; 136: 35-43 (NKI)

992. Lips EH, Mulder L, de Ronde JJ, Mandjes IA, Vincent A, Vrancken Peeters MJ, Nederlof PM, Wesseling J, Rodenhuis S. Neoadjuvant chemotherapy in ER+ HER2- breast cancer: response prediction based on immunohistochemical and molecular characteristics. Breast Cancer Res Treat 2012; 131: 827-36 (NKI)

993. Lips IM, van Gils CH, Kotte AN, van Leerdam ME, Franken SP, van der Heide UA, van Vulpen M. A doubleblind placebo-controlled randomized clinical trial with magnesium oxide to reduce intrafraction prostate motion for prostate cancer radiotherapy. Int J Radiat Oncol Biol Phys 2012; 83: 653-60 (NKI)

994. Litiere S, Werutsky G, Fentiman IS, Rutgers E, Christiaens MR, Van Limbergen E, Baaijens MH, Bogaerts J, Bartelink H. Breast conserving therapy versus mastectomy for stage I-II breast cancer: 20 year follow-up of the EORTC 10801 phase 3 randomised trial. Lancet Oncol 2012; 13: 412-9 (NKI)

995. Lodder EM, Scicluna BP, Milano A, Sun AY, Tang H, Remme CA, Moerland PD, Tanck MWT, Pitt GS, Marchuk DA, Bezzina CR. Dissection of a quantitative trait locus for PR interval duration identifies Tnni3k as a novel modulator of cardiac conduction. PLOS Genetics 2012; 8(12): e1003113-. (AMC)

996. Lodder WL, Pameijer FA, Rasch CR, van den Brekel MW, Balm AJ. Prognostic significance of radiologically determined neck node volume in head and neck cancer: a systematic review. Oral Oncol 2012; 48: 298-302 (NKI/AMC)

997. Lo-Fo-Wong DNN, Ranchor AV, de Haes HCJM, Sprangers MAG, Henselmans I. Complementary and alternative medicine use of women with breast cancer: self-help CAM attracts other women than guided CAM therapies. Patient Education And Counseling 2012; 89(3): 529-536. (AMC)

998. Loibl S, Han SN, von Minckwitz G, Bontenbal M, Ring A, Giermek J, Fehm T, Van Calsteren K, Linn SC, Schlehe B, Gziri MM, Westenend PJ, Muller V, Heyns L, Rack B, Van Calster B, Harbeck N, Lenhard M, Halaska MJ, Kaufmann M, Nekljudova V, Amant F. Treatment of breast cancer during pregnancy: an observational study. Lancet Oncol 2012; 13: 887-96 (NKI)

999. Lok A, Mocking RJT, Ruhé HG , Visser I , Koeter MWJ, Assies J, Bockting CLH, Olff M, Schene AH. Longitudinal hypothalamic-pituitary-adrenal axis trait and state effects in recurrent depression. Psychoneuroendocrinology 2012; 37(7): 892-902. (AMC)

1000. Lok CA, Snijder KS, Nieuwland R, Van Der Post JA, de Vos P, Faas MM. Microparticles of pregnant women and preeclamptic patients activate endothelial cells in the presence of monocytes. Am J Reprod Immunol 2012; 67: 206-15 (NKI)

1001. Lokhorst HM, van der Holt B, Cornelissen JJ, Kersten MJ, van Oers M, Raymakers R, Minnema MC, Zweegman S, Janssen JJ, Zijlmans M, Bos G, Schaap N, Wittebol S, de Weerdt O, Ammerlaan R, Sonneveld P. Donor versus no-donor comparison of newly diagnosed myeloma patients included in the HOVON-50 multiple myeloma study. Blood 2012; 119(26): 6219-25; quiz 6399. (VUmc/AMC)

1002. London K, Stege C, Cross S, Onikul E, Graf N, Kaspers G, la-Pozza L, Howman-Giles R. F-18-FDG PET/CT compared to conventional imaging modalities in pediatric primary bone tumors. Pediatric Radiology 2012; 42: 418-430. (VUmc)

1003. Lopes N, Paredes J, Costa JL, Ylstra B, Schmitt F. Vitamin D and the mammary gland: a review on its role in normal development and breast cancer. Breast Cancer Research 2012; 14: 211. (VUmc)


1004. Louwers JA, Berkhof J, Zaal A, Kocken M, Rozendaal L, Heideman DAM, van Baal WM, Snijders PJF, Verheijen RHM, Meijer CJLM. HrHPV-testing in a university hospital gynecology outpatient clinic: Recommendations for clinical practice. Gynecol Oncol 2012; 124: 518-524. (VUmc)

1005. Lubberink M, Direcks W, Emmering J, van Tinteren H, Hoekstra OS, van der Hoeven JJ, Molthoff CF, Lammertsma AA. Validity of simplified 3’-deoxy-3’-[(18)f]fluorothymidine uptake measures for monitoring response to chemotherapy in locally advanced breast cancer. Mol Imaging Biol 2012; 14: 777-782 (VUmc/NKI)

1006. Lucassen W, van Weert HC, Büller H. Clinical Decision Rules for Excluding Pulmonary Embolism. Annals Of Internal Medicine 2012; 156(2): 169-170. (AMC)

1007. Luijten PR, van Dongen GAMS, Moonen CT, Storm G, Crommelin DJA. Public-private partnerships in translational medicine: Concepts and practical examples. Journal of Controlled Release 2012; 161: 416-421. (VUmc)

1008. Lutgens MWMD, van Oijen MGH, Vleggaar FP, Siersema PD, Broekman MMTJ, Oldenburg B. Risk Factors for Rectal Stump Cancer in Inflammatory Bowel Disease. Diseases of the Colon & Rectum 2012; 55: 191-196. (VUmc)

1009. Lutz MP, Zalcberg JR, Ducreux M, Ajani JA, Allum W, Aust D, Bang YJ, Cascinu S, Hölscher A, Jankowski J, Jansen EP, Kisslich R, Lordick F, Mariette C, Moehler M, Oyama T, Roth A, Rueschoff J, Ruhstaller T, Seruca R, Stahl M, Sterzing F, van Cutsem E, van der Gaast A, van Lanschot J, Ychou M, Otto F; First St Gallen EORTC Gastrointestinal Cancer Conference 2012 Expert Panel. Highlights of the EORTC St. Gallen International Expert Consensus on the primary therapy of gastric, gastroesophageal and oesophageal cancer – Differential treatment strategies for subtypes of early gastroesophageal cancer. Eur J Cancer 2012; 48: 2941-53 (NKI)

1010. Ma YP, van Leeuwen FE, Cooke R, Broeks A, Enciso-Mora V, Olver B, Lloyd A, Broderick P, Russell NS, Janus C, Ashworth A, Houlston RS, Swerdlow AJ. FGFR2 genotype and risk of radiation-associated breast cancer in Hodgkin lymphoma. Blood 2012; 119: 1029-31 (NKI)

1011. Maas K, Biere S, Van der Peet D, Cuesta M. Minimally invasive esophagectomy: current status and future direction. Surgical Endoscopy and Other Interventional Techniques 2012; 26: 1794. (VUmc)

1012. Maas KW, Biere SSAY, Scheepers JJG, Gisbertz SS, Rodriguez VT, van der Peet DL, Cuesta MA. Minimally invasive intrathoracic anastomosis after Ivor Lewis esophagectomy for cancer: a review of transoral or transthoracic use of staplers. Surgical Endoscopy and Other Interventional Techniques 2012; 26: 1795-1802. (VUmc)

1013. Maas KW, Biere SSAY, Scheepers JJG, Gisbertz SS, van der Peet DL, Cuesta MA. Laparoscopic versus open transhiatal esophagectomy for distal and junction cancer. Revista Espanola de Enfermedades Digestivas 2012; 104: 197-202. (VUmc)

1014. Maaskant-Braat AJ, Roumen RM, Voogd AC, Pijpers R, Luiten EJ, Rutgers EJT, Nieuwenhuijzen GA. Sentinel Node and Recurrent Breast Cancer (SNARB): Results of a Nationwide Registration Study. Ann Surg Oncol. 2012 (NKI)

1015. Mac Aogain M, Kulah C, Rijnsburger M, Celebi G, Savelkoul PHM, O'Gara F, Mooij MJ. Characterization of imipenem resistance mechanisms in Pseudomonas aeruginosa isolates from Turkey. Clinical Microbiology and Infection 2012; 18: E262-E265. (VUmc)

1016. Madougou S, Santcroos M, Benabdelkader A, van Schaik BDC, Shahand S, Korkhov V, van Kampen AHC, Olabarriaga SD. Provenance for distributed biomedical workflow execution. Studies In Health Technology And Informatics 2012; 175: 91-100. (AMC)

1017. Magasi S, Ryan G, Revicki D, Lenderking W, Hays RD, Brod M, Snyder C, Boers M, Cella D. Content validity of patient-reported outcome measures: perspectives from a PROMIS meeting. Quality of Life Research 2012; 21: 739-746. (VUmc)

1018. Magnani L, Carroll J, Zwart W, Palmieri C. ChIPing away at breast cancer. Lancet Oncol 2012; 13: 1185-7 (NKI) 1019. Maguire CA, van der Mijn JC, Degeling MH, Morse D, Tannous BA. Codon-Optimized Luciola italica Luciferase Variants

for Mammalian Gene Expression in Culture and In Vivo. Molecular Imaging 2012; 11: 13-21. (VUmc) 1020. Mai PL, Malkin, D, Garber J, Schiffman JD, Witzel JN, Strong L, Wyss O, Locke L, Means V, Achatz MI, Hainaut P,

Frebourg T, Evans DG, Bleiker E, Patenaude A, Schneider K, Wilfond B, Peters J, Hwang PM, Ford J, Tabori U, Ognjanovic S, Dennis P, Wentzensen IM, Greene MH, Fraumeni JF jr, Savage SA. Li-Fraumeni syndrome: Report of a clinical research workshop and creation of a research consortium. Cancer Genetics 2012; 205: 479-487 (NKI)

1021. Maibach R, Roebuck D, Brugieres L, Capra M, Brock P, Dall'Igna P, Otte J, de Camargo B, Zsiros J, Zimmermann A, Aronson D, Childs M, Scopinaro M, Morland B, Plaschkes J, Czauderna P, Perilongo G. Prognostic stratification for children with hepatoblastoma: the SIOPEL experience. European Journal Of Cancer 2012; 48(10): 1543-1549. (AMC)

1022. Maillette de Buy Wenniger L, Rauws EA, Beuers U. What an endoscopist should know about immunoglobulin-G4-associated disease of the pancreas and biliary tree. Endoscopy 2012; 44(1): 66-73. (AMC)

1023. Majera D, Kristan K , Neefjes J, Turk D, Miheli M. Expression, purification and assembly of soluble multimeric MHC class II-invariant chain complexes. FEBS Lett 2012; 586: 1: 318-24 (NKI)

1024. Majewski IJ, Kluijt I, Cats A, Scerri TS, de Jong D, Kluin RJ, Hansford S, Hogervorst FB, Bosma AJ, Hofland I, Winter M, Huntsman D, Jonkers J, Bahlo M, Bernards R. An alpha- E-catenin (CTNNA1) mutation in hereditary diffuse gastric cancer. J Pathol. 2012 (NKI)

1025. Makharia GK, Catassi C, Goh KL, Mulder CJJ. Celiac Disease. Gastroenterology Research and Practice 2012; 758560: . (VUmc)

1026. Malekzadeh A, de Groot V, Beckerman H, van Oosten BW, Blankenstein MA, Teunissen C. Challenges in multi-plex and mono-plex platforms for the discovery of inflammatory profiles in neurodegenerative diseases. Methods 2012; 56: 508-513. (VUmc)

1027. Mallette FA, Mattiroli F, Cui G, Young LC, Hendzel MJ, Mer G, Sixma TK, Richard S. RNF8- and RNF168- dependent degradation of KDM4A/ JMJD2A triggers 53BP1 recruitment to DNA damage sites. EMBO J 2012; 31: 1865-78 (NKI)

1028. Mammatas LH, Regelink JC, Klein IE, Barbe E, Huijgens PC. Palmar necrosis during the treatment of acute myeloid leukaemia. Netherlands Journal of Medicine 2012; 70: 467. (VUmc)

1029. Mamoulakis C, Skolarikos A, Schulze M, Scoffone CM, Rassweiler JJ, Alivizatos G, Scarpa RM, de La Rosette JJMCH. Results from an international multicentre double-blind randomized controlled trial on the perioperative efficacy and safety of bipolar vs monopolar transurethral resection of the prostate. BJU International 2012; 109(2): 240-248 (AMC)

1030. Manson ML, Derissen EJ, Wijermans PW, Schellens JH, Beijnen JH. Demethylating medication in myelodysplastic syndrome. Ned Tijdschr Geneeskd 2012; 156: A3167 (NKI)

1031. Margadant C, Kreft M, de Groot DJ, Norman JC, Sonnenberg, A. Distinct roles of talin and kindlin in regulating integrin a5b1 function and trafficking. Curr Biol 2012; 22: 1554-63 (NKI)

1032. Margadant C, van den Bout I, van Boxtel AL, Thijssen VL, Sonnenberg A. Epigenetic regulation of galectin-3 expression by integrin a5b1 promotes cell adhesion and migration. J Biol Chem 2012; 287: 44684-93 (NKI/VUmc)


1033. Markov PV, van de Laar TJ, Thomas XV, Aronson SJ, Weegink CJ, van den Berk GE, Prins M, Pybus OG, Schinkel J. Colonial History and Contemporary Transmission Shape the Genetic Diversity of Hepatitis C Virus Genotype 2 in Amsterdam. Journal of Virology 2012; 86: 7677-7687. (VUmc)

1034. Martens HA, Nienhuis HLA, Gross S, van der Steege G, Brouwer E, Berden JHM, de Sevaux RGL, Derksen RHWM, Voskuyl AE, Berger SP, Navis GJ, Nolte IM, Kallenberg CGM, Bijl M. Receptor for advanced glycation end products (RAGE) polymorphisms are associated with systemic lupus erythematosus and disease severity in lupus nephritis. Lupus 2012; 21: 959-968. (VUmc)

1035. Martin JE, Broen JC, Carmona FD, Teruel M, Simeon CP, Vonk MC, van 't Slot R, Rodriguez-Rodriguez L, Vicente E, Fonollosa V, Ortego-Centeno N, Gonzalez-Gay MA, Garcia-Hernandez FJ, de la Pena PG, Carreira P, Voskuyl AE, Schuerwegh AJ, van Riel PLCM, Kreuter A, Witte T, Riemekasten G, Airo P, Scorza R, Lunardi C, Hunzelmann N, Distler JHW, Beretta L, van Laar J, Chee MM, Worthington J, Herrick A, Denton C, Tan FK, Arnett FC, Assassi S, Fonseca C, Mayes MD, Radstake TRDJ, Koeleman BPC, Martin J. Identification of CSK as a systemic sclerosis genetic risk factor through Genome Wide Association Study follow-up. Human Molecular Genetics 2012; 21: 2825-2835. (VUmc)

1036. Martin JE, Carmona FD, Broen JCA, Simeon CP, Vonk MC, Carreira P, Rios-Fernandez R, Espinosa G, Vicente-Rabaneda E, Tolosa C, Garcia-Hernandez FJ, Castellvi I, Fonollosa V, Gonzalez-Gay MA, Saez-Comet L, Portales RG, de la Pena PG, Fernandez-Castro M, Diaz B, Martinez-Estupinan L, Coenen M, Voskuyl AE, Schuerwegh AJ, Vanthuyne M, Houssiau F, Smith V, de Keyser F, De Langhe E, Riemekasten G, Witte T, Hunzelmann N, Kreuter A, Palm O, Chee MM, van Laar JM, Denton C, Herrick A, Worthington J, Koeleman BPC, Radstake TRDJ, Fonseca C, Martin J. The autoimmune disease-associated IL2RA locus is involved in the clinical manifestations of systemic sclerosis. Genes and Immunity 2012; 13: 191-196. (VUmc)

1037. Maruyama K, Nakazawa T, Cursiefen C, Maruyama Y, Van Rooijen N, D'Amore PA, Kinoshita S. The Maintenance of Lymphatic Vessels in the Cornea Is Dependent on the Presence of Macrophages. Invest Ophth Vis Sci 2012; 53: 3145-3153. (VUmc)

1038. Mathus-Vliegen EMH. Endobarrier: een uniek maar onvoldoende uitgerijpt concept. Nederlands Tijdschrift Voor Geneeskunde 2012; 156(13): A4590-. (AMC)

1039. Mathus-Vliegen EMH. Obesity and the elderly. Journal Of Clinical Gastroenterology 2012; 46(7): 533-544. (AMC) 1040. Mathus-Vliegen EMH. Prevalence, pathophysiology, health consequences and treatment options of obesity in the

elderly: a guideline. Obesity Facts 2012; 5(3): 460-483. (AMC) 1041. Mattarollo SR, West AC, Steegh K, Duret H, Paget C, Martin B, Matthews GM, Shortt J, Chesi M, Bergsagel PL, Bots M,

Zuber J, Lowe SW, Johnstone RW, Smyth MJ. NKT cell adjuvant-based tumor vaccine for treatment of myc oncogene-driven mouse B-cell lymphoma. Blood 2012; 120(15): 3019-3029. (AMC)

1042. Mattiroli F, Vissers JH, van Dijk WJ, Ikpa P, Citterio E, Vermeulen W, Marteijn JA, Sixma TK. RNF168 ubiquitinates K13-15 on H2A/H2AX to drive DNA damage signaling. Cell 2012; 150: 1182-95 (NKI)

1043. Mavaddat N, et al; Consortium of Investigators of Modifiers of BRCA1/2 [234 collaborators ao: Hogervorst FB, Verhoef S, Van Leeuwen FE, Rookus MA]. Pathology of breast and ovarian cancers among BRCA1 and BRCA2 mutation carriers: results from the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA). Cancer Epidemiol Biomarkers Prev 2012; 21: 134-147 (NKI)

1044. Mawhinney LA, Thawer SG, Lu WY, Van Rooijen N, Weaver LC, Brown A, Dekaban GA. Differential Detection and Distribution of Microglial and Hematogenous Macrophage Populations in the Injured Spinal Cord of lys-EGFP-ki Transgenic Mice. Journal of Neuropathology and Experimental Neurology 2012; 71: 180-197. (VUmc)

1045. Maxwell CA, Benítez J, Gómez-Baldó L, Osorio A, Bonifaci N, Fernández-Ramires R, Costes SV, Guinó E, Chen H, Evans GJ, Mohan P, Català I, Petit A, Aguilar H, Villanueva A, Aytes A, Serra-Musach J, Rennert G, Lejbkowicz F, Peterlongo P, Manoukian S, Peissel B, Ripamonti CB, Bonanni B, Viel A, Allavena A, Bernard L, Radice P, Friedman E, Kaufman B, Laitman Y, Dubrovsky M, Milgrom R, Jakubowska A, Cybulski C, Gorski B, Jaworska K, Durda K, Sukiennicki G, Lubiński J, Shugart YY, Domchek SM, Letrero R, Weber BL, Hogervorst FB, Rookus MA, Collee JM, Devilee P, Ligtenberg MJ, Luijt RB, Aalfs CM, Waisfisz Q, Wijnen J, Roozendaal CE; HEBON; EMBRACE, Easton DF, Peock S, Cook M, Oliver C, Frost D, Harrington P, Evans DG, Lalloo F, Eeles R, Izatt L, Chu C, Eccles D, Douglas F, Brewer C, Nevanlinna H, Heikkinen T, Couch FJ, Lindor NM, Wang X, Godwin AK, Caligo MA, Lombardi G, Loman N, Karlsson P, Ehrencrona H, Wachenfeldt Av; SWE-BRCA, Barkardottir RB, Hamann U, Rashid MU, Lasa A, Caldés T, Andrés R, Schmitt M, Assmann V, Stevens K, Offit K, Curado J, Tilgner H, Guigó R, Aiza G, Brunet J, Castellsagué J, Martrat G, Urruticoechea A, Blanco I, Tihomirova L, Goldgar DE, Buys S, John EM, Miron A, Southey M, Daly MB; BCFR, Schmutzler RK, Wappenschmidt B, Meindl A, Arnold N, Deissler H, Varon-Mateeva R, Sutter C, Niederacher D, Imyamitov E, Sinilnikova OM, Stoppa-Lyonne D, Mazoyer S, Verny-Pierre C, Castera L, de Pauw A, Bignon YJ, Uhrhammer N, Peyrat JP, Vennin P, Fert Ferrer S, Collonge-Rame MA, Mortemousque I; GEMO Study Collaborators, Spurdle AB, Beesley J, Chen X, Healey S; kConFab, Barcellos-Hoff MH, Vidal M, Gruber SB, Lázaro C, Capellá G, McGuffog L, Nathanson KL, Antoniou AC, Chenevix-Trench G, Fleisch MC, Moreno V, Pujana MA. Interplay between BRCA1 and RHAMM regulates epithelial apicobasal polarization and may influence risk of breast cancer. PLoS Biol 2011; 9 (NKI)

1046. McClung MR, Boonen S, Torring O, Roux C, Rizzoli R, Bone HG, Benhamou CL, Lems WF, Minisola S, Halse J, Hoeck HC, Eastell R, Wang A, Siddhanti S, Cummings SR. Effect of denosumab treatment on the risk of fractures in subgroups of women with postmenopausal osteoporosis. Journal of Bone and Mineral research 2012; 27: 211-218. (VUmc)

1047. Medema RH, Macurek L. Checkpoint control and cancer. Oncogene 2012; 31: 2601-13 (NKI) 1048. Mees SMD, Algra A, Vandertop WP, van Kooten F, Kuijsten HAJM, Boiten J, van Oostenbrugge RJ, Salman RA, Lavados

PM, Rinkel GJE, van den Bergh WM. Magnesium for aneurysmal subarachnoid haemorrhage (MASH-2): a randomised placebo-controlled trial. Lancet 2012; 380: 44-49. (VUmc)

1049. Meesters JJL, de Boer IG, van den Berg MH, Fiocco M, Vlieland TPMV. Evaluation of a website providing information on regional health care services for patients with rheumatoid arthritis: an observational study. Clinical Rheumatology 2012; 31: 637-645. (VUmc)

1050. Meevissen MHJ, Driessen NN, Smits HH, Versteegh R, van Vliet SJ, van Kooyk Y, Schramm G, Deelder AM, Haas H, Yazdanbakhsh M, Hokke CH. Specific glycan elements determine differential binding of individual egg glycoproteins of the human parasite Schistosoma mansoni by host C-type lectin receptors. International Journal for Parasitology 2012; 42: 269-277. (VUmc)

1051. Meijer CJLM, Berkhof J. Screening: Cervical cancer-should we abandon cytology for screening?. Nature Reviews Clinical Oncology 2012; 9: 558-559. (VUmc)


1052. Meijer RP, Meinhardt W, van der Poel HG, van Rhijn BW, Kerst JM, Pos FJ, et al. Local control rate and prognosis after sequential chemoradiation for small cell carcinoma of the bladder. International journal of urology: official journal of the Japanese Urological Association. 2012 (NKI)

1053. Meijer RP, Nunnink CJ, Wassenaar AE, Bex A, van der Poel HG, van Rhijn BW, et al. Standard lymph node dissection for bladder cancer: significant variability in the number of reported lymph nodes. J Urol 2012; 187: 446-50 (NKI)

1054. Meijer RP, van Rhijn BW. A plea for long-term surveillance in bacillus Calmette-Guerin-treated non-muscleinvasive bladder cancer. Eur Urol 2012; 61: 508-9 (NKI)

1055. Meinhardt W, van der Poel HG, Valdes Olmos RA, Bex A, Brouwer OR, Horenblas S. Laparoscopic sentinel lymph node biopsy for prostate cancer: the relevance of locations outside the extended dissection area. Prostate Cancer 2012; 2012: 751753 (NKI)

1056. Meinhardt-Wollweber M, Krebs R. A computational model for previtamin D(3) production in skin. Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 2012; 11: 731-7 (NKI)

1057. Meissner TB, Liu YJ, Lee KH, Li A, Biswas A, van Eggermond MC, van den Elsen PJ, Kobayashi KS. NLRC5 Cooperates with the RFX Transcription Factor Complex To Induce MHC Class I Gene Expression. J Immunol 2012; 188: 4951-4958. (VUmc)

1058. Mekenkamp LJM, Heesterbeek CJ, Punt CJA, Nagtegaal ID. Reply letter to: Signet ring cell carcinoma as a potential confounding factor in the analysis of outcomes with colorectal mucinous adenocarcinoma. European Journal Of Cancer 2012; 48(16): 3128-3129. (AMC)

1059. Mekenkamp LJM, Heesterbeek KJ, Koopman M, Tol J, Teerenstra S, Venderbosch S, Punt CJA, Nagtegaal ID. Mucinous adenocarcinomas: Poor prognosis in metastatic colorectal cancer. European Journal Of Cancer 2012; 48(4): 501-509. (AMC)

1060. Mekenkamp LJM, Tol J, Dijkstra JR, de Krijger I, Vink-Borger ME, van Vliet S, Teerenstra S, Kamping E, Verwiel E, Koopman M, Meijer GA, van Krieken JHJM, Kuiper R, Punt CJA, Nagtegaal ID. Beyond KRAS mutation status: influence of KRAS copy number status and microRNAs on clinical outcome to cetuximab in metastatic colorectal cancer patients. BMC Cancer 2012; 12: . (VUmc/AMC)

1061. Melief J, Koning N, Schuurman KG, van de Garde MDB, Smolders J, Hoek RM, van Eijk M, Hamann J, Huitinga I. Phenotyping primary human microglia: Tight regulation of LPS responsiveness. Glia 2012; 60: 1506-1517. (VUmc)

1062. Meliopoulos VA, Andersen LE, Birrer KF, Simpson KJ, Lowenthal JW, Bean AGD, Stambas J, Stewart CR, Tompkins SM, van Beusechem VW, Fraser I, Mhlanga M, Barichievy S, Smith Q, Leake D, Karpilow J, Buck A, Jona G, Tripp RA. Host gene targets for novel influenza therapies elucidated by high-throughput RNA interference screens. Faseb Journal 2012; 26: 1372-1386. (VUmc)

1063. Melo CA, Drost J, Wijchers, PJ, van de Werken H, de Wit E, Oude Vrielink JA, Elkon R, Melo SA, Leveille N, Kalluri R, de Laat W and Agami R. eRNAs Are Required for p53-Dependent Enhancer Activity and Gene Transcription. Mol Cell. 2012 (NKI)

1064. Melsen WG, De Smet AMGA, Kluytmans JAJW, Bonten MJM. Selective decontamination of the oral and digestive tract in surgical versus non-surgical patients in intensive care in a cluster-randomized trial. British Journal of Surgery 2012; 99: 232-237. (VUmc)

1065. Mencarelli A, van Beek S, van Kranen S, Rasch C, van Herk M, Sonke JJ. Validation of deformable registration in head and neck cancer using analysis of variance. Medical Physics 2012; 39(11): 6879-6884. (AMC/NKI)

1066. Menendez-Benito V, van Deventer SJ, Jimenez-Garcia V, Roy-Luzarraga M, van Leeuwen F, Neefjes J. Spatiotemporal analysis of organelle and macromolecular complex inheritance. Proc Natl Acad Sci USA. 2013; 110: 175-80 (NKI)

1067. Mergler S, Rieken R, Tibboel D, Evenhuis HM, van Rijn RR, Penning C. Lumbar spine and total-body dual-energy X-ray absorptiometry in children with severe neurological impairment and intellectual disability: a pilot study of artefacts and disrupting factors. Pediatric Radiology 2012; 42(5): 574-583. (AMC)

1068. Merkx R, Burns KE, et al. Synthesis and evaluation of a selective fluorogenic Pup derived assay reagent for Dop, a potential drug target in Mycobacterium tuberculosis. Chembiochem 2012: 13: 2056-2060 (NKI)

1069. Mérol JC, Charpiot A, Langagne T, Hémar P, Ackerstaff AH, Hilgers FJM. Randomized controlled trial on postoperative pulmonary humidification after total laryngectomy: External Humidifier versus Heat and Moisture Exchanger. Laryngoscope 2012; 122: 275-81 (NKI)

1070. Mertens L, Meijer R, Nunnink C, Bex A, van der Poel H, van Rhijn B, Wassenaar A, van Werkhoven E, Meinhardt W & Horenblas S. Standaard Lymfeklierdissectie Bij Blaascarcinoom: Significante Verschillen In Het Aantal Gerapporteerde Lymfeklieren Tijdschrift voor Urologie, 2012; 2: 144- 150 (NKI)

1071. Mertens LS, Bruin NM, Vegt E, de Blok WM, Fioole-Bruining A, van Rhijn BW, Horenblas S, Vogel WV. Catheterassisted 18F-FDG-PET/CT imaging of primary bladder cancer: a prospective study. Nucl Med Commun 2012; 33: 1195-201 (NKI)

1072. Mertens LS, Fioole-Bruining A, van Rhijn BW, Kerst JM, Bergman AM, Vogel WV, Vegt E, Horenblas S. FDG-PET/CT in Monitoring Response of Pelvic Lymph Node Metastases to Neoadjuvant Chemotherapy in Bladder Cancer. J Urol 2012 (NKI)

1073. Mertens LS, Meijer RP, Kerst JM, Bergman AM, van Tinteren H, van Rhijn BW, Horenblas S. Carboplatin based induction chemotherapy for nonorgan confined bladder cancer - a reasonable alternative for cisplatin unfit patients? J Urol 2012; 188: 1108-13 (NKI)

1074. Mertens LS, Meijer RP, van Werkhoven E, Bex A, van der Poel HG, van Rhijn BW, Meinhardt W & Horenblas S. Differences in histopathological evaluation of standard lymph node dissections result in differences in nodal count but not in survival World J Urol 2012 (NKI)

1075. Mertens LS, Meinhardt W, Rier WB, Nooter RI, Horenblas S. Extravasation of intravesical chemotherapy for non-muscle-invasive bladder cancer. Urol Int 2012; 89: 332-6 (NKI)

1076. Metske HA, Postema PG, Biemond BJ, Bouman CSC. Cooling the crisis: therapeutic hypothermia after sickle cardiac arrest. Critical Care Medicine 2012; 40(2): 651-653. (AMC)

1077. Meulenbeld H, van Werkhoven, E, Coenenc J, Creemers G, Loosvelde O, de Jong P, ten Tije A, Fossah S, Poleei M, Gerritsen W, Dalesio O. & de Wit R. Randomized phase II/III study of Docetaxel with or without Risedronate in patients with metastatic Castration Resistant Prostate Cancer (CRPC), the Netherlands Prostate Study (NePro) European Journal Of Cancer 2012; 48: 2993-3000 (NKI/VUMc)

1078. Meunier F, Lawler M, Pinedo HM. Commentary: Fifty Years of the European Organisation for Research and Treatment of Cancer (EORTC) - Making the Difference for the European Oncology Community. Oncologist 2012; 17: e6-e7. (VUmc)


1079. Mewes JC, Steuten LMG, IJzerman MJ, Van Harten WH. Effectiveness of multidimensional cancer survivor rehabilitation and cost effectiveness of cancer rehabilitation in general: a systematic review. The Oncologist, 2012; 17: 1581-93 (NKI)

1080. Mi RJ, Song LN, Wang YC, Ding XK, Zeng JW, Lehoux S, Aryal RP, Wang JM, Crew VK, van Die I, Chapman AB, Cummings RD, Ju TZ. Epigenetic Silencing of the Chaperone Cosmc in Human Leukocytes Expressing Tn Antigen. Journal of Biological Chemistry 2012; 287: 41523-41533. (VUmc)

1081. Michels M, van der Ven AJAM, Djamiatun K, Fijnheer R, de Groot PG, Griffioen AW, Sebastian S, Faradz SMH, de Mast Q. Imbalance of Angiopoietin-1 and Angiopoetin-2 in Severe Dengue and Relationship with Thrombocytopenia, Endothelial Activation, and Vascular Stability. American Journal of Tropical Medicine and Hygiene 2012; 87: 943-946. (VUmc)

1082. Middelbeek J, Kuipers AJ, Henneman L, Visser D, Eidhof I, van Horssen R, Wieringa B, Canisius SV, Zwart W, Wessels LFA, Sweep FC, Bult P, Span PN, van Leeuwen FN, Jalink K. TRPM7 is required for breast tumour cell metastasis. Cancer Res 2012; 72: 4250- 61 (NKI)

1083. Mieog JS, Morden JP, Bliss JM, Coombes RC, van de Velde CJ; IES Steering Committee. Carpal tunnel syndrome and musculoskeletal symptoms in postmenopausal women with early breast cancer treated with exemestane or tamoxifen after 2-3 years of tamoxifen: a retrospective analysis of the Intergroup Exemestane Study. Lancet Oncol 2012; 13: 420-32 (NKI/AMC)

1084. Miller EM, Obernosterer G, Raaben M, Herbert AS, Deffieu MS, Krishnan A, Ndungo E, Sandesara RG, Carette JE, Kuehne AI, Ruthel G, Pfeffer SR, Dye JM, Whelan SP, Brummelkamp TR, Chandran K. Ebola virus entry requires the host-programmed recognition of an intracellular receptor. EMBO J 2012; 31: 1946-60 (NKI)

1085. Milstein DM, van Kuijen AM, Copper MP, Karakullukçu B, Tan IB, Lindeboom JA, Fokkens WJ, Ince C. Monitoring microcirculatory alterations in oral squamous cell carcinoma following photodynamic therapy. Photodiagnosis Photodyn Ther 2012; 9: 69-75 (NKI/AMC)

1086. Mingels MJ, Roelofsen T, van der Laak JA, de Hullu JA, van Ham MA, Massuger LF, Bulten J, Bol M. Tubal epithelial lesions in salpingooophorectomy specimens of BRCAmutation carriers and controls. Gynecol Oncol 2012; 127: 88-93 (NKI)

1087. Mischi M, Kuenen MPJ, Wijkstra H. Angiogenesis imaging by spatiotemporal analysis of ultrasound contrast agent dispersion kinetics. Ieee Transactions On Ultrasonics Ferroelectrics And Frequency Control 2012; 59(4): 621-629. (AMC)

1088. Mishra AK, Alves JE, Krumbach K, Nigou J, Castro AG, Geurtsen J, Eggeling L, Saraiva M, Besra GS. Differential Arabinan Capping of Lipoarabinomannan Modulates Innate Immune Responses and Impacts T Helper Cell Differentiation. Journal of Biological Chemistry 2012; 287: 44173-44183. (VUmc)

1089. Mitra D, Kampondeni S, Mallewa M, Knight T, Skinner R, Banda K, Israels T, Molyneux E, Bailey S. Central nervous system lesions in Malawian children: identifying the treatable. Transactions of the Royal Society of Tropical Medicine and Hygiene 2012; 106: 567-569. (VUmc)

1090. Miura K, Yang L, Van Rooijen N, Ohnishi H, Seki E. Hepatic recruitment of macrophages promotes nonalcoholic steatohepatitis through CCR2. American Journal of Physiology-Gastrointestinal and Liver Physiology 2012; 302: G1310-G1321. (VUmc)

1091. Miyairi I, Ziebarth J, Laxton JD, Wang XF, Van Rooijen N, Williams RW, Lu L, Byrne GI, Cui Y. Host Genetics and Chlamydia Disease: Prediction and Validation of Disease Severity Mechanisms. PloS one 2012; 7: . (VUmc)

1092. Mjösberg J , Bernink J, Golebski K, Karrich JJ, Peters CP, Blom B, te Velde AA, Fokkens WJ, van Drunen CM, Spits H. The transcription factor GATA3 is essential for the function of human type 2 innate lymphoid cells. Immunity 2012; 37(4): 649-659. (AMC)

1093. Mjösberg J, Bernink J, Peters C, Spits H. Transcriptional control of innate lymphoid cells. European Journal Of Immunology 2012; 42(8): 1916-1923. (AMC)

1094. Mocking RJT, Assies J, Lok A, Ruhé HG, Koeter MWJ, Visser I, Bockting CLH, Schene AH. Statistical methodological issues in handling of fatty acid data: percentage or concentration, imputation and indices. Lipids 2012; 47(5): 541-547. (AMC)

1095. Moghadasi S, Hofland N, Wouts JN, Hogervorst FB, Wijnen JT, Vreeswijk MP, van Asperen CJ. Variants of Uncertain Significance in BRCA1 and BRCA2 assessment of in silico analysis and a proposal for communication in genetic counselling. J Med Genet 2012 (NKI)

1096. Molenaar Jan J., Koster Jan, Ebus Marli E., van Sluis Peter, Westerhout Ellen M., de Preter Katleen, Gisselsson David, Øra Ingrid, Speleman Frank, Caron Huib N., Versteeg Rogier: Copy number defects of G1-cell cycle genes in neuroblastoma are frequent and correlate with high expression of E2F target genes and a poor prognosis. Genes Chromosomes & Cancer 2012; 51(1): 10-19. (AMC)

1097. Molenaar JJ, Domingo-Fernández R, Ebus ME, Lindner S, Koster J, Drabek K, Mestdagh P, van Sluis P, Valentijn LJ, van Nes J, Broekmans M, Haneveld F, Volckmann R, Bray I, Heukamp L, Sprüssel A, Thor T, Kieckbusch K, Klein-Hitpass L, Fischer M, Vandesompele J, Schramm A, van Noesel MM, Varesio L, Speleman F, Eggert A, Stallings RL, Caron HN, Versteeg R, Schulte JH. LIN28B induces neuroblastoma and enhances MYCN levels via let-7 suppression. Nature Genetics 2012; 44(11): 1199-1206. (AMC)

1098. Molenaar JJ, Koster J, Zwijnenburg DA, van Sluis P, Valentijn LJ, van der Ploeg I, Hamdi M, van Nes J, Westerman BA, van Arkel J, Ebus ME, Haneveld F, Lakeman A, Schild L, Molenaar P, Stroeken P, van Noesel MM, Ora I, Santo EE, Caron HN, Westerhout EM, Versteeg R. Sequencing of neuroblastoma identifies chromothripsis and defects in neuritogenesis genes. Nature 2012; 483(7391): 589-593. (AMC)

1099. Moll A, Dommering C, Bosscha M, de Graaf P, Kors WA, van Leeuwen F. Risk Factors for the Incidence of Second Cancers in Survivors of Retinoblastoma With a Family History. Journal of Clinical Oncology 2012; 30: 3028 (NKI/VUmc)

1100. Mollers M, Scherpenisse M, van der Klis FRM, King AJ, van Rossum TGJ, van Logchem EM, Feltkamp MC, Meijer CJLM, Snijders PJF, Boot HJ, de Melker HE. Prevalence of genital HPV infections and HPV serology in adolescent girls, prior to vaccination. Cancer Epidemiology 2012; 36: 519-524. (VUmc)

1101. Molyneux EM, Rochford R, Griffin B, Newton R, Jackson G, Menon G, Harrison CJ, Israels T, Bailey S. Burkitt's lymphoma. Lancet 2012; 379(9822): 1234-1244. (AMC/Vumc)

1102. Montorsi F, Wilson TG, Rosen RC, Ahlering TE, Artibani W, Carroll PR, et al. Best practices in robotassisted radical prostatectomy: recommendations of the Pasadena Consensus Panel. Eur Urol 2012; 62: 368-81 (NKI)

1103. Mooiman KD, Goey AK, Meijerman I, Beijnen JH, Schellens JH. Letter to the editor regarding "A prospective, controlled study of the botanical compound mixture LCS101 for chemotherapy-induced hematological complications


in breast cancer" by Yaal-Hahoshen et al. (The Oncologist 2011; 16: 1197-1202). Oncologist 2012; 17: 740-1; author reply 742-3 (NKI)

1104. Moolenaar WH, Hla T. SnapShot: Bioactive lysophospolipids. Cell 2012; 148: 378-378.e2 (NKI) 1105. Moran R, van Kuilenburg ABP, Duley J, Nabuurs SB, Retno-Fitri A, Christodoulou J, Roelofsen J, Yntema HG, Friedman

NR, van Bokhoven H, de Brouwer APM. Phosphoribosylpyrophosphate synthetase superactivity and recurrent infections is caused by a p.Val142Leu mutation in PRS-I. American Journal Of Medical Genetics Part A 2012; 158A(2): 455-460. (AMC)

1106. Morata K, Komori M, Fujinami R, Yamada K, Kuribayashi K, Watanabe N, Sokoll LJ, Elliott D, Chan DW, Martens F, Heijboer AC, Blankenstein MA, Hershberger SJ, Pfeiffer ZA, Vaidya SV, Dowell BL. Improvement and multicenter evaluation of the analytical performance of an automated chemiluminescent immunoassay for alpha fetoprotein. Int J Biol Markers 2012; 27: 39-46. (VUmc)

1107. Morris AR, Bos A, Diosdado B, Rooijers K, Elkon R, Bolijn AS, Carvalho B, Meijer GA and Agami R. Alternative Cleavage and Polyadenylation during Colorectal Cancer Development. Clin Cancer Res 2012; 18: 5256-66 (NKI/VUmc)

1108. Morton L, Gilbert ES, Hall P, Andersson M, Joensuu H, Vaalavirta L, Dores GM, Stovall M, Holowaty EJ, Lynch CF, Curtis RE, Smith SA, Kleinerman RA, Kaijser M, Storm HH, Pukkala E, Weathers RE, Linet MS, Rajaraman P, Fraumeni JF Jr, Brown LM, van Leeuwen FE, Fossa SD, Johannesen TB, Langmark F, Lamart S, Travis LB, Aleman BM. Risk of treatmentrelated esophageal cancer among breast cancer survivors. Ann Oncol 2012: 23: 3081-91 (NKI)

1109. Mosca M, Boumpas D, Bruce IN, Cervera R, Czirjak L, Dorner T, Houssiau F, Jacobsen S, Schneider M, Smolen JS, Voskuyl AE, van Vollenhoven RF. Treat-to-target in systemic lupus erythematosus: where are we today?. Clinical and Experimental Rheumatology 2012; 30: S112-S115. (VUmc)

1110. Mostert S, Njuguna F, Kemps L, Strother M, Aluoch L, Buziba G, Kaspers G. Epidemiology of diagnosed childhood cancer in Western Kenya. Archives of Disease in Childhood 2012; 97: 508-512. (VUmc)

1111. Mostert S, Sitaresmi MN, Njuguna F, van Beers EJ, Kaspers GJL. Effect of corruption on medical care in low-income countries. Pediatric Blood & Cancer 2012; 58: 325-326. (VUmc)

1112. Mougiakakos D, Okita R, Ando T, Dürr C, Gadiot J, Ichikawa J, Zeiser R, Blank C, Johansson C, Kiessling R. High expression of GCLC is associated with malignant melanoma of low oxidative phenotype and predicts a better prognosis. J Mol Med 2012; 90: 935-44 (NKI)

1113. Moulin V, Morgan ME, Eleveld- Trancikova D, Haanen JB, Wielders E, Looman MW, Janssen RA, Figdor CG, Jansen BJ, Adema GJ. Targeting dendritic cells with antigen via dendritic cell-associated promoters. Cancer Gene Ther 2012; 19: 303-11 (NKI)

1114. Mouw E, van't Noordende G, van Kampen AHC, Louter B, Santcroos M, Olabarriaga SD. Legal constraints on genetic data processing in European grids. Studies In Health Technology And Informatics 2012; 175: 49-58. (AMC)

1115. Mud MS, Kremer LCM, Sieswerda E, van der Pal HJH. Zorg voor overlevenden van kinderkanker in Nederland. Nederlands Tijdschrift Voor Geneeskunde 2012; 156(9): A4199-. (AMC)

1116. Mues AC, Korets R, Graversen JA, Badani KK, Bird VG, Best SL, Cadeddu JA, Clayman RV, McDougall E, Barwari K, Laguna P, de la Rosette J, Kavoussi L, Okhunov Z, Munver R, Patel SR, Nakada S, Tsivian M, Polascik TJ, Shalhav A, Shingleton WB, Johnson EK, Wolf Jr. JS, Landman J. Clinical, pathologic, and functional outcomes after nephron-sparing surgery in patients with a solitary kidney: a multicenter experience. Journal Of Endourology 2012; 26(10): 1361-1366. (AMC)

1117. Muggia F, Diaz I, Peters GJ. Nucleoside and nucleobase analogs in cancer treatment: not only sapacitabine, but also gemcitabine. Expert Opinion on Investigational Drugs 2012; 21: 403-408. (VUmc)

1118. Mulder GM, Melenhorst WBWH, Celie JWAM, Kloosterhuis NJ, Hillebrands JL, Ploeg RJ, Seelen MA, Visser L, van Dijk MCRF, van Goor H. ADAM17 up-regulation in renal transplant dysfunction and non-transplant-related renal fibrosis. Nephrology Dialysis Transplantation 2012; 27: 2114-2122. (VUmc)

1119. Mulder RL, Paulides M, Langer T, Kremer LCM, van Dalen EC. Cyclophosphamide versus ifosfamide for paediatric and young adult bone and soft tissue sarcoma patients. Cochrane Database Of Systematic Reviews 2012; 2012(12): CD006300-. (AMC)

1120. Mulder SA, Kranse R, Damhuis RA, Ouwendijk RJ, Kuipers EJ, van Leerdam ME. The incidence and risk factors of metachronous colorectal cancer: an indication for follow-up. Dis Colon Rectum 2012; 55: 522-31 (NKI)

1121. Munk AC, Gudlaugsson E, Malpica A, Fiane B, Lovslett KI, Kruse AJ, Ovestad IT, Voorhorst F, Janssen EAM, Baak JPA. Consistent Condom Use Increases the Regression Rate of Cervical Intraepithelial Neoplasia 2-3. PloS one 2012; 7: . (VUmc)

1122. Muñoz J, Stange DE, Schepers AG, van de Wetering M, Koo BK, Itzkovitz S, Volckmann R, Kung KS, Koster J, Radulescu S, Myant K, Versteeg R, Sansom OJ, van Es JH, Barker N, van Oudenaarden A, Mohammed S, Heck AJR, Clevers H. The Lgr5 intestinal stem cell signature: robust expression of proposed quiescent '+4' cell markers. Embo Journal 2012; 31(14): 3079-3091. (AMC)

1123. Murillo CP, Huang X, Hills A, McGurk M, Lyons A, Jeannon JP, Odell E, Brown A, Lavery K, Barrett W, Sherriff M, Brakenhoff R, Partridge M. The utility of molecular diagnostics to predict recurrence of head and neck carcinoma. Br J Cancer 2012; 107: 1138-1143. (VUmc)

1124. Muris J, Feilzer AJ, Kleverlaan CJ, Rustemeyer T, van Hoogstraten IMW, Scheper RJ, von Blomberg BME. Palladium-induced Th2 cytokine responses reflect skin test reactivity. Allergy 2012; 67: 1605-1608. (VUmc)

1125. Muris J, Kleverlaan CJ, Rustemeyer T, von Blomberg ME, van Hoogstraten IMW, Feilzer AJ, Scheper RJ. Sodium tetrachloropalladate for diagnosing palladium sensitization. Contact Dermatitis 2012; 67: 94-100. (VUmc)

1126. Muthupalani S, Ge ZM, Feng Y, Rickman B, Mobley M, McCabe A, Van Rooijen N, Fox JG. Systemic Macrophage Depletion Inhibits Helicobacter bilis-Induced Proinflammatory Cytokine-Mediated Typhlocolitis and Impairs Bacterial Colonization Dynamics in a BALB/c Rag2(-/-) Mouse Model of Inflammatory Bowel Disease. Infection and Immunity 2012; 80: 4388-4397. (VUmc)

1127. Nacerddine K, Beaudry JB, Ginjala V, Westerman B, Mattiroli F, Song JY, van der Poel H, Ponz OB, Pritchard C, Cornelissen-Steijger P, Zevenhoven J, Tanger E, Sixma TK, Ganesan S, van Lohuizen M. Akt-mediated phosphorylation of Bmi1 modulates its oncogenic potential, E3 ligase activity, and DNA damage repair activity in mouse prostate cancer. J Clin Invest 2012; 122: 1920-32 (NKI)

1128. Nachtegaal J, Festen JM, Kramer SE. Hearing Ability in Working Life and Its Relationship With Sick Leave and Self-Reported Work Productivity. Ear and Hearing 2012; 33: 94-103. (VUmc)


1129. Naessens T, Vander Beken S, van Bogaert P, Van Rooijen N, Lienenklaus S, Weiss S, de Koker S, Grooten J. Innate Imprinting of Murine Resident Alveolar Macrophages by Allergic Bronchial Inflammation Causes a Switch from Hypoinflammatory to Hyperinflammatory Reactivity. American Journal of Pathology 2012; 181: 174-184. (VUmc)

1130. Nagel JHA, Peeters JK, Smid M, Sieuwerts AM, Wasielewski M, de Weerd V, Trapman-Jansen AMAC, van den Ouweland A, Brüggenwirth H, van I Jcken WFJ, Klijn JGM, van der Spek PJ, Foekens JA, Martens JWM, Schutte M, Meijers-Heijboer H. Gene expression profiling assigns CHEK2 1100delC breast cancers to the luminal intrinsic subtypes. Breast Cancer Research And Treatment 2012; 132(2): 439-448. (VUmc/AMC)

1131. Nagler A, Labopin M, Shimoni A, Mufti GJ, Cornelissen JJ, Blaise D, Janssen JJWM, Milpied N, Vindelov L, Petersen E, Gribben J, Bacigalupo A, Malm C, Niederwieser D, Socie GJ, Arnold R, Brown P, Goker H, Rocha V, Mohty M. Mobilized peripheral blood stem cells compared with bone marrow from HLA-identical siblings for reduced-intensity conditioning transplantation in acute myeloid leukemia in complete remission: a retrospective analysis from the Acute Leukemia Working Party of EBMT. European Journal of Haematology 2012; 89: 206-213. (VUmc)

1132. Nagtegaal MJC, Pentinga SE, Kuik J, Kezic S, Rustemeyer T. The role of the skin irritation response in polysensitization to fragrances. Contact Dermatitis 2012; 67: 28-35. (VUmc)

1133. Natrajan R, Mackay A, Wilkerson PM, Lambros MB, Wetterskog D, Arnedos M, Shiu KK, Geyer FC, Langerød A, Kreike B, Reyal F, Horlings HM, van de Vijver MJ, Palacios J, Weigelt B, Reis-Filho JS. Functional characterization of the 19q12 amplicon in grade III breast cancers. Breast Cancer Research 2012; 14(2): R53-. (AMC)

1134. Neefjes J, Sadaka C. Into the intracellular logistics of crosspresentation. Front Immunol 2012; 3: 31 (NKI) 1135. nephrectomy: is there an advantage of the self-retaining barbed suture in the perioperative period? A matched

case-control comparison. World Journal Of Urology 2012; 30(5): 659-664. (AMC) 1136. Nes JGH, Fontein DBY, Hille ETM, Voskuil DW, Leeuwen FE, Haes JCJM, Putter H, Seynaeve C, Nortier JWR, Velde

CJH. Quality of life in relation to tamoxifen or exemestane treatment in postmenopausal breast cancer patients: a Tamoxifen Exemestane Adjuvant Multinational (TEAM) Trial side study. Breast Cancer Res Treat 2012; 134: 267-276 (NKI)

1137. Newbold A, Vervoort SJ, Martin BP, Bots M, Johnstone RW. Induction of autophagy does not alter the anti-tumor effects of HDAC inhibitors. Cell Death & Disease 2012; 3: e387-. (AMC)

1138. Nguyen VD, Weiss N, Beeker W, Hoekman M, Leinse A, Heideman RG, van Leeuwen TG, Kalkman J. Integrated-optics-based swept-source optical coherence tomography. Optics Letters 2012; 37(23): 4820-4822. (AMC)

1139. Nicolaou N, Margadant C, Kevelam SH, Lilien MR, Oosterveld MJ, Kreft M, van Eerde, AM, Pfundt R, Terhal PA, van der Zwaag B, Nikkels PG, Sachs N, Goldschemding R, Knoers NVAM, Renkema KY, Sonnenberg A. Gain-ofglycosylation in integrin a3 causes lung disease and nephrotic syndrome. J Clin Invest 2012; 122: 4375-87 (NKI)

1140. Niers JM, Chen JW, Lewandrowski G, Kerami M, Garanger E, Wojtkiewicz G, Waterman P, Keliher E, Weissleder R, Tannous BA. Single Reporter for Targeted Multimodal in Vivo Imaging. Journal of the American Chemical Society 2012; 134: 5149-5156. (VUmc)

1141. Nieuwenhuis MH, Douma KFL, Bleiker EMA, Aaronson NK, Clevers H, Vasen HFA. Clinical evidence for an association between familial adenomatous polyposis and type II diabetes. International Journal Of Cancer 2012; 131(6): 1488-1489. (AMC/NKI)

1142. Nieweg OE, Hoekstra HJ. Respons op ‘Gerandomiseerd onderzoek leidt to meer vragen over schildwachtklierbiopsie bij het melanoom’, Van Akkooi ACJ, Verhoef C, De Wilt JHW. Ned Tijdschr Oncol 2012; 3: 134-135 (NKI)

1143. Nieweg OE, Nieweg OE. Behandeling van hematogene metasasen van melanoom in beweging. Editorial bij de bijdrage van K.P. Wevers, G.A.P. Hospers en H.J. Hoekstra, getiteld ‘Fase IIIstudie: chirurgische of systemische behandeling van resectabele hematogene melanoommetastasen’. Ned Tijdschr Oncol 2012; 9: 42-43 (NKI)

1144. Niini T, Scheinin I, Lahti L, Savola S, Mertens F, Hollmen J, Bohling T, Kivioja A, Nord KH, Knuutila S. Homozygous deletions of cadherin genes in chondrosarcoma-an array comparative genomic hybridization study. Cancer Genetics 2012; 205: 588-593. (VUmc)

1145. Nijhuis R, van Zwet A, Stuart JC, Weijers T, Savelkoul P. Rapid molecular detection of extended-spectrum beta-lactamase gene variants with a novel ligation-mediated real-time PCR. Journal of Medical Microbiology 2012; 61: 1563-1567. (VUmc)

1146. Nijkamp J, de Haas-Kock DFM, Beukema JC, Neelis KJ, Woutersen D, Ceha H, Rozema T, Slot A, Vos-Westerman H, Intven M, Spruit PH, van der Linden Y, Geijsen D, Verschueren K, van Herk MB, Marijnen CAM. Target volume delineation variation in radiotherapy for early stage rectal cancer in the Netherlands. Radiotherapy And Oncology 2012; 102(1): 14-21. (AMC/VUmc/NKI)

1147. Nijkamp J, Doodeman B, Marijnen C, Vincent A, van Vliet-Vroegindeweij C. Bowel exposure in rectal cancer IMRT using prone, supine, or a belly board. Radiother Oncol 2012; 102: 22-9 (NKI)

1148. Nijkamp J, Marijnen C, van Herk M, van Triest B, Sonke JJ. Adaptive radiotherapy for long course neoadjuvant treatment of rectal cancer. Radiother Oncol 2012; 103: 353-9 (NKI)

1149. Nijkamp J, Swellengrebel M, Hollmann B, de Jong R, Marijnen C, van Vliet- Vroegindeweij C, van Triest B, van Herk M, Sonke JJ. Repeat CT assessed CTV variation and PTV margins for short- and long-course pre-operative RT of rectal cancer. Radiother Oncol 2012; 102: 399-405 (NKI)

1150. Nijman JL, Sixma H, van Triest B, Keus R, Hendriks M. The quality of radiation care: The results of focus group interviews and concept mapping to explore the patient’s perspective. Radiother Oncol 2012; 102: 154-60 (NKI)

1151. Nowak-Sliwinska P, Weiss A, van Beijnum JR, Wong TJ, Ballini JP, Lovisa B, van den Bergh H, Griffioen AW. Angiostatic kinase inhibitors to sustain photodynamic angio-occlusion. Journal of Cellular and Molecular Medicine 2012; 16: 1553-1562. (VUmc)

1152. Numan RC, Klomp HM, Li W, Buitelaar DR, Burgers JA, Van Sandick JW, Wouters MW. A clinical audit in a multidisciplinary care path for thoracic surgery: an instrument for continuous quality improvement. Lung Cancer 2012; 78: 270-5 (NKI)

1153. Nur E, Brandjes DP, Teerlink T, Otten H, Oude Elferink RPJ, Muskiet F, Evers LM, ten Cate H, Biemond BJ, Duits AJ, Schnog JB. N-acetylcysteine reduces oxidative stress in sickle cell patients. Annals Of Hematology 2012; 91(7): 1097-1105. (AMC)

1154. Nurmohamed MT, van der Horst-Bruinsma I, Maksymowych WP. Cardiovascular and cerebrovascular diseases in ankylosing spondylitis: current insights. Current Rheumatology Reports 2012; 14: 415-421. (VUmc)

1155. Nutt SL, Mebius RE. Lymphocyte activation and effector functions. Current Opinion in Immunology 2012; 24: 253-254. (VUmc)


1156. Nyst HJ, Wildeman MA, Indrasari SR, Karakullukcu B, Van Veen RL, Adham M, Stewart FA, Levendag PC, Sterenborg HJ, Tan IB. Temoporfin mediated photodynamic therapy in patients with local persistent and recurrent nasopharyngeal carcinoma after curative radiotherapy: A feasibility study. Photodiagnosis Photodyn Ther 2012; 9: 274-81 (NKI)

1157. Oates CJ, Hennessy BT, Lu Y, Mills GB, Mukherjee S. Network Inference Using Steady-State Data and Goldbeter- Koshland Kinetics. Bioinformatics 2012; 28: 2342-48 (NKI)

1158. Oates CJ, Mukherjee S. Network inference and biological dynamics. Ann Appl Stat 2012; 6: 1209-35 (NKI) 1159. Oberlin O, Rey A, Sanchez de Toledo J, Martelli H, Jenney MEM, Scopinaro M, Bergeron C, Merks JHM, Bouvet N,

Ellershaw C, Kelsey A, Spooner D, Stevens MCG. Randomized Comparison of Intensified Six-Drug Versus Standard Three-Drug Chemotherapy for High-Risk Nonmetastatic Rhabdomyosarcoma and Other Chemotherapy-Sensitive Childhood Soft Tissue Sarcomas: Long-Term Results From the International Society of Pediatric Oncology MMT95 Study. Journal Of Clinical Oncology 2012; 30(20): 2457-2465. (AMC)

1160. Ohri N, Werner-Wasik M, Grills IS, Belderbos J, Hope A, Yan D, Kestin LL, Guckenberger M, Sonke JJ, Bissonnette JP, Xiao Y. Modeling local control after hypofractionated stereotactic body radiation therapy for stage I non-small cell lung cancer: a report from the elekta collaborative lung research group. Int J Radiat Oncol Biol Phys 2012; 84: 379-84 (NKI)

1161. Okeke Z, Smith AD, Labate G, D'Addessi A, Venkatesh R, Assimos D, Strijbos WEM, de La Rosette JJMCH. Prospective comparison of outcomes of percutaneous nephrolithotomy in elderly patients versus younger patients. Journal Of Endourology 2012; 26(8): 996-1001. (AMC)

1162. Olde Nordkamp LRA, Dabiri Abkenari L, Boersma LVA, Maass AH, de Groot JR, van Oostrom AJHHM, Theuns DAMJ, Jordaens LJLM, Wilde AAM, Knops RE. The entirely subcutaneous implantable cardioverter-defibrillator: initial clinical experience in a large Dutch cohort. Journal Of The American College Of Cardiology 2012; 60(19): 1933-1939. (AMC)

1163. Olde Nordkamp LRA, Knops RE, Bardy GH, Blaauw Y, Boersma LVA, Bos JS, Delnoy PPHM, van Dessel PFHM, Driessen AHG, de Groot JR, Herrman JPR, Jordaens LJLM, Kooiman KM, Maass AH, Meine M, Mizusawa Y, Molhoek SG, van Opstal J, Tijssen JGP, Wilde AAM. Rationale and design of the PRAETORIAN trial: a Prospective, RAndomizEd comparison of subcuTaneOus and tRansvenous ImplANtable cardioverter-defibrillator therapy. American Heart Journal 2012; 163(5): 753-760.e2. (AMC)

1164. Oliveira S, Cohen R, Walsum MS, van Dongen GA, Elias SG, van Diest PJ, Mali W, van Bergen en Henegouwen PM. A novel method to quantify IRDye800CW fluorescent antibody probes ex vivo in tissue distribution studies. Eur J Nucl Med Mol Imaging 2012; 2: 50. (VUmc)

1165. Oliveira S, van Dongen GAMS, Stigter-van Walsum M, Roovers RC, Stam JC, Mali W, van Diest PJ, van Bergen en Henegouwen P. Rapid Visualization of Human Tumor Xenografts through Optical Imaging with a Near-infrared Fluorescent Anti-Epidermal Growth Factor Receptor Nanobody. Molecular Imaging 2012; 11: 33-46. (VUmc)

1166. Olmos D, A'hern RP, Marsoni S, Morales R, Gomez-Roca C, Verweij J, Voest EE, Schöffski P, Ang JE, Penel N, Schellens JH, Del Conte G, Brunetto AT, Evans TR, Wilson R, Gallerani E, Plummer R, Tabernero J, Soria JC, Kaye SB. Patient selection for oncology phase I trials: a multi-institutional study of prognostic factors. J Clin Oncol 2012; 30: 996-1004 (NKI)

1167. Ong CL, Verbakel WFAR, Dahele M, Cuijpers JP, Slotman BJ, Senan S. Fast Arc Delivery for Stereotactic Body Radiotherapy of Vertebral and Lung Tumors. International Journal of Radiation Oncology Biology Physics 2012; 83: E137-E143. (VUmc)

1168. Ontoso D, Acosta I, van Leeuwen F, Freire R, San-Segundo PA. Dot1- Dependent Histone H3K79 Methylation Promotes Activation of the Mek1 Meiotic Checkpoint Effector Kinase by Regulating the Hop1 Adaptor. PLoS Genetics. 2013; 9: e1003262 (NKI)

1169. Oonk AM, van Rijn C, Smits MM, Mulder L, Laddach N, Savola SP, Wesseling J, Rodenhuis S, Imholz AL, Lips EH. Clinical correlates of “BRCAness” in triple-negative breast cancer of patients receiving adjuvant chemotherapy. Ann Oncol 2012; 23: 2301-5 (NKI)

1170. Oosterhoff D, Lougheed S, van de Ven R, Lindenberg J, van Cruijsen H, Hiddingh L, Kroon J, van den Eertwegh AJ, Hangalapura B, Scheper RJ, de Gruijl TD. Tumor-mediated inhibition of human dendritic cell differentiation and function is consistently counteracted by combined p38 MAPK and STAT3 inhibition. Oncoimmunology 2012; 1: 649-658. (VUmc)

1171. Oosterhoff D, Sluijter BJR, Hangalapura BN, de Gruijl TD. The dermis as a portal for dendritic cell-targeted immunotherapy of cutaneous melanoma. Current Topics in Microbiology and Immunology 2012; 351: 181-220. (VUmc)

1172. Oosterhuis K, Aleyd E, Vrijland K, Schumacher TN, Haanen JB. Rational design of DNA vaccines for the induction of human papillomavirus type 16 e6- and e7-specific cytotoxic T-cell responses. Hum Gene Ther 2012; 23: 1301-12 (NKI)

1173. Oosterhuis K, van den Berg JH, Schumacher TN, Haanen JB. DNA vaccines and intradermal vaccination by DNA tattooing. Curr Top Microbiol Immunol 2012; 351: 221-50 (NKI)

1174. Oostlander AE, Bravenhoer N, van Essen HW, Klein-Nulend J, Lems WF, Schulten BAJM, Dijkstra G, van der Woude CJ, van Bodegraven AA, Lips P. Bone Cells From Patients With Quiescent Crohn's Disease Show a Reduced Growth Potential and an Impeded Maturation. Journal of Cellular Biochemistry 2012; 113: 2424-2431. (VUmc)

1175. Oostlander AE, Everts V, Schoenmaker T, Bravenboer N, van Vliet SJ, van Bodegraven AA, Lips P, De Vries TJ. T cell-mediated increased osteoclast formation from peripheral blood as a mechanism for crohn's disease-associated bone loss. Journal of Cellular Biochemistry 2012; 113: 260-268. (VUmc)

1176. Oostra A, van Furth W, Georgalas C. Extended endoscopic endonasal skull base surgery: from the sella to the anterior and posterior cranial fossa. Anz Journal Of Surgery 2012; 82(3): 122-130. (AMC)

1177. Oostra AB, Nieuwint AWM, Joenje H, de Winter JP. Diagnosis of fanconi anemia: chromosomal breakage analysis. Anemia 2012; 2012: 238731. (VUmc)

1178. Oostra RJ, Keulen N, Jansen T, van Rijn RR. Absence of the spleen(s) in conjoined twins: a diagnostic clue of laterality defects? Radiological study of historical specimens. Pediatric Radiology 2012; 42(6): 653-659. (AMC) Opdam FL, Guchelaar HJ, Beijnen JH, Schellens JH. Lapatinib for advanced or metastatic breast cancer. Oncologist 2012; 17: 536-42 (NKI)

1179. Opondo D, Tefekli A, Esen T, Labate G, Sangam K, de Lisa A, Shah H, de la Rosette J. Impact of case volumes on the outcomes of percutaneous nephrolithotomy. European Urology 2012; 62(6): 1181-1187. (AMC)


1180. Oprea-Lager DE, Vincent AD, van Moorselaar RJ, Gerritsen WR, van den Eertwegh AJ, Eriksson J, Boellaard R, Hoekstra OS. Dual-phase PET-CT to differentiate [18F]Fluoromethylcholine uptake in reactive and malignant lymph nodes in patients with prostate cancer. PLoS One 2012; 7: e48430 (NKI/VUmc)

1181. Orem J, Sandin S, Weibull CE, Odida M, Wabinga H, Mbidde E, Wabwire-Mangen F, Meijer CJLM, Middeldorp JM, Weiderpass E. Agreement between diagnoses of childhood lymphoma assigned in Uganda and by an international reference laboratory. Clinical Epidemiology 2012; 4: 339-347. (VUmc)

1182. Orlova DY, Stixová L, Kozubek S, Gierman HJ, Šustáčková G, Chernyshev AV, Medvedev RN, Legartová S, Versteeg R, Matula P, Stoklasa R, Bártová E. Arrangement of nuclear structures is not transmitted through mitosis but is identical in sister cells. Journal Of Cellular Biochemistry 2012; 113(11): 3313-3329. (AMC)

1183. Osanto S, Bex A, Hulsbergen-van de Kaa CA, Soetekouw PM, Stemkens D. [The Dutch guideline ‘Renal cell carcinoma’]. Nederlands tijdschrift voor geneeskunde 2012; 156: A4462 (NKI)

1184. Osipov AV, Rucktooa P, Kasheverov IE, Filkin SY, Starkov VG, Andreeva TV, Sixma TK, Bertrand D, Utkin YN, Tsetlin VI. Dimeric alpha-cobratoxin X-ray structure: localization of intermolecular disulfides and possible mode of binding to nicotinic acetylcholine receptors. J Biol Chem 2012; 287: 6725-34 (NKI)

1185. Ossenkoppele G, Evans-Jones G, Jaeger U, Hellstrom-Lindberg E. Towards a joint definition of European hematology. Haematologica-The Hematology Journal 2012; 97: 636-637. (VUmc)

1186. Ossenkoppele GJ, Stussi G, Maertens J, van Montfort K, Biemond BJ, Breems D, Ferrant A, Graux C, de Greef GE, Halkes CJM, Hoogendoorn M, Hollestein RM, Jongen-Lavrencic M, Levin MD, van de Loosdrecht AA, van Marwijk Kooij M, van Norden Y, Pabst T, Schouten HC, Vellenga E, Verhoef GEG, de Weerdt O, Wijermans P, Passweg JR, Lowenberg B. Addition of bevacizumab to chemotherapy in acute myeloid leukemia at older age: a randomized phase 2 trial of the Dutch-Belgian Cooperative Trial Group for Hemato-Oncology (HOVON) and the Swiss Group for Clinical Cancer Research (SAKK). Blood 2012; 120: 4706-4711. (VUmc/AMC)

1187. Otten MA, Bakema JE, Tuk CW, Glennie MJ, Tutt AL, Beelen RH, van de Winkel JGJ, van Egmond M. Enhanced Fc alpha RI-mediated neutrophil migration towards tumour colonies in the presence of endothelial cells. European Journal of Immunology 2012; 42: 1815-1821. (VUmc)

1188. Ottenhof NA, de Wilde RF, Morsink FHM, de Leng WWJ, Ausems MGEM, Morreau H, van Hillegersberg R, Offerhaus GJA, Milne AN. Pancreatic ductal adenocarcinoma in hereditary diffuse gastric cancer. A case report. Human Pathology 2012; 43(3): 457-461. (AMC)

1189. Ottenhof NA, Morsink FHM, ten Kate F, van Noorden CJF, Offerhaus GJA. Multivariate analysis of immunohistochemical evaluation of protein expression in pancreatic ductal adenocarcinoma reveals prognostic significance for persistent Smad4 expression only. Cellular Oncology (Dordrecht) 2012; 35(2): 119-126. (AMC)

1190. Otto SJ, Fracheboud J, Verbeek ALM, Boer R, Reijerink-Verheij JCIY, Otten JDM, Broeders MJM, de Koning HJ. Mammography screening and risk of breast cancer death: a population-based case-control study. Cancer Epidemiology Biomarkers & Prevention 2012; 21(1): 66-73. (AMC)

1191. Out AA, Wasielewski M, Huijts PEA, van Minderhout IJHM, Houwing-Duistermaat JJ, Tops CMJ, Nielsen M, Seynaeve C, Wijnen JT, Breuning MH, van Asperen CJ, Schutte M, Hes FJ, Devilee P. MUTYH gene variants and breast cancer in a Dutch case-control study. Breast Cancer Research and Treatment 2012; 134: 219-227. (VUmc)

1192. Ouwehand K, Spiekstra SW, Waaijman T, Breetveld M, Scheper RJ, de Gruijl TD, Gibbs S. CCL5 and CCL20 mediate immigration of Langerhans cells into the epidermis of full thickness human skin equivalents. European Journal of Cell Biology 2012; 91: 765-773. (VUmc)

1193. Overbeek A, Broekmans FJ, Hehenkamp WJ, Wijdeveld ME, van Disseldorp J, van Dulmen-den Broeder E, Lambalk CB. Intra-cycle fluctuations of anti-Mullerian hormone in normal women with a regular cycle: a re-analysis. Reproductive Biomedicine Online 2012; 24: 664-669. (VUmc)

1194. Overbeek A, van den Berg M, Hukkelhoven C, Kaspers GJ, van Dulmen-den Broeder E, Lambalk C, van Leeuwen F. Validity of Self-Reported Data on Pregnancy Outcomes - Comparing Self-Reported Data of Childhood Cancer Survivors with Data from A Nationwide Population-Based Registry. Pediatric Blood & Cancer 2012; 59: 974. (VUmc)

1195. Overbeek A, van den Berg MH, Hukkelhoven CWPM, Kremer LC, Heuvel-Eibrink MM, Tissing WJE, Loonen JJ, Versluys AB, Bresters D, Kaspers GJL, Lambalk CB, van Leeuwen FE, Dulmen-den Broeder E, On Behalf of the DCOG LATER/VEVO Study Group. Validity of self-reported data on pregnancies for childhood cancer survivors: a comparison with data from a nationwide populationbased registry. Human Reprod 2012 (NKI)

1196. Overbeek A, van den Berg MH, Kremer LC, van den Heuvel-Eibrink MM, Tissing WJ, Loonen JJ, Versluys B, Bresters D, Kaspers GJ, Lambalk CB, van Leeuwen FE, van Dulmen-den Broeder E, on behalf of the DCOG LATER-VEVO study group. A nationwide study on reproductive function, ovarian reserve, and risk of premature menopause in female servivors of childhood cancer: design and methodological challenges. BMC Cancer 2012; 12: 363. (VUmc/NKI/AMC)

1197. Overdevest ITMA, Heck M, van der Zwaluw K, Willemsen I, van de Ven J, Verhulst C, Kluytmans JAJW. Comparison of SpectraCell RA Typing and Multilocus Sequence Typing for Extended-Spectrum-beta-Lactamase-Producing Escherichia coli. Journal of Clinical Microbiology 2012; 50: 3999-4001. (VUmc)

1198. Overgaard J, Bartelink H. Introduction: towards predicting outcome of radiotherapy-at last. Semin Radiat Oncol 2012; 22: 87-90 (NKI)

1199. Pabittei DR, Heger M, Simonet M, van Tuijl S, van der Wal AC, Beek JF, Balm R, de Mol BA. Biodegradable polymer scaffold, semi-solid solder, and single-spot lasing for increasing solder-tissue bonding in suture-free laser-assisted vascular repair. Journal Of Tissue Engineering And Regenerative Medicine 2012; 6(10): 803-812. (AMC)

1200. Pabst T, Vellenga E, van Putten W, Schouten HC, Graux C, Vekemans MC, Biemond B, Sonneveld P, Passweg J, Verdonck L, Legdeur MC, Theobald M, Jacky E, Bargetzi M, Maertens J, Ossenkoppele GJ, Lowenberg B. Favorable effect of priming with granulocyte colony-stimulating factor in remission induction of acute myeloid leukemia restricted to dose escalation of cytarabine. Blood 2012; 119: 5367-5373. (VUmc)\

1201. Palma D, Lagerwaard F, Rodrigues G, Haasbeek C, Senan S. Curative Treatment of Stage I Non-Small-Cell Lung Cancer in Patients with Severe Copd: Stereotactic Radiotherapy Outcomes and Systematic Review. International Journal of Radiation Oncology Biology Physics 2012; 82: 1149-1156. (VUmc)

1202. Palma DA, Haasbeek CJA, Rodrigues GB, Dahele M, Lock M, Yaremko B, Olson R, Liu M, Panarotto J, Griffioen GHMJ, Gaede S, Slotman B, Senan S. Stereotactic ablative radiotherapy for comprehensive treatment of oligometastatic tumors (SABR-COMET): Study protocol for a randomized phase II trial. BMC Cancer 2012; 12: . (VUmc)

1203. Palma DA, Senan S. Early-Stage Non-Small Cell Lung Cancer in Elderly Patients: Should Stereotactic Radiation Therapy Be the Standard of Care?. International Journal of Radiation Oncology Biology Physics 2012; 84: 1058-1059. (VUmc)


1204. Pascal V, Laffleur B, Debin A, Cuvillier A, van Egmond M, Drocourt D, Imbertie L, Pangault C, Tarte K, Tiraby G, Cogne M. Anti-CD20 IgA can protect mice against lymphoma development: evaluation of the direct impact of IgA and cytotoxic effector recruitment on CD20 target cells. Haematologica-The Hematology Journal 2012; 97: 1686-1694. (VUmc)

1205. Paul, P. The Systems Biology of MHC class II antigen presentation. Thesis. Leiden University, 2012 (cum laude) (NKI) 1206. Peccatori FA, Giovannetti E, Pistilli B, Bellettini G, Codacci-Pisanelli G, Losekoot N, Curigliano G, Peccatori HA, Azim

GA, Peters GJ. "The only thing I know is that I know nothing": 5-fluorouracil in human milk. Annals of Oncology 2012; 23: 543-544. (VUmc)

1207. Peifer M, Fernandez-Cuesta L, Sos ML, George J, Seidel D, Kasper LH, Plenker D, Leenders F, Sun R, Zander T, Menon R, Koker M, Dahmen I, Muller C, Di Cerbo V, Schildhaus HU, Altmuller J, Baessmann I, Becker C, de Wilde B, Vandesompele J, Bohm D, Ansen S, Gabler F, Wilkening I, Heynck S, Heuckmann JM, Lu X, Carter SL, Cibulskis K, Banerji S, Getz G, Park KS, Rauh D, Grutter C, Fischer M, Pasqualucci L, Wright G, Wainer Z, Russell P, Petersen I, Chen Y, Stoelben E, Ludwig C, Schnabel P, Hoffmann H, Muley T, Brockmann M, Engel-Riedel W, Muscarella LA, Fazio VM, Groen H, Timens W, Sietsma H, Thunnissen E, Smit EF, Heideman DAM, Snijders PJF, Cappuzzo F, Ligorio C, Damiani S, Field J, Solberg S, Brustugun OT, Lund-Iversen M, Sanger J, Clement JH, Soltermann A, Moch H, Weder W, Solomon B, Soria JC, Validire P, Besse B, Brambilla E, Brambilla C, Lantuejoul S, Lorimier P, Schneider PM, Hallek M, Pao W, Meyerson M, Sage J, Shendure J, Schneider R, Buttner R, Wolf J, Nurnberg P, Perner S, Heukamp LC, Brindle PK, Haas S, Thomas RK. Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer. Nature Genetics 2012; 44: 1104-1110. (VUmc)

1208. Peiser M, Tralau T, Heidler J, Api AM, Arts JHE, Basketter DA, English J, Diepgen TL, Fuhlbrigge RC, Gaspari AA, Johansen JD, Karlberg AT, Kimber I, Lepoittevin JP, Liebsch M, Maibach HI, Martin SF, Merk HF, Platzek T, Rustemeyer T, Schnuch A, Vandebriel RJ, White IR, Luch A. Allergic contact dermatitis: epidemiology, molecular mechanisms, in vitro methods and regulatory aspects Current knowledge assembled at an international workshop at BfR, Germany. Cellular and Molecular Life Sciences 2012; 69: 763-781. (VUmc)

1209. Penel N, Demetri GD, Blay JY, Cousin S, Maki RG, Chawla SP, Judson I, Van Mehren M, Schöffski P, Verweij J, Casali P, Rodenhuis S, Schütte HJ, Cassar A, Gomez J, Nieto A, Zintl P, Pontes MJ, Le Cesne A. Growth modulation index as metric of clinical benefit assessment among advanced soft tissue sarcoma patients receiving trabectedin as a salvage therapy. Ann Oncol. 2012 (NKI)

1210. Pérez-Mancera PA, Rust AG, van der Weyden L, Kristiansen G, Li A, Sarver AL, Silverstein KAT, Grützmann R, Aust D, Rümmele P, Knösel T, Herd C, Stemple DL, Kettleborough R, Brosnan JA, Li A, Morgan R, Knight S, Yu J, Stegeman S, Collier LS, ten Hoeve J, de Ridder J, Goggins M, Hruban RH, Biankin AV, Grimmond SM, APGI, Wessels LFA, Wood SA, Iacobuzio- Donahue CA, Pilarsky C, Largaespada DA, Adams DA, Tuveson DA. The deubiquitinase USP9X suppresses pancreatic ductal adenocarcinoma, Nature 2012; 486: 266-70 (NKI)

1211. Peters GJ, Bijnsdorp IV. TAS-102: more than an antimetabolite. Lancet Oncology 2012; 13: E518-E519. (VUmc) 1212. Peters GJ, Chatelut E, Larsen AK, Zaffaroni N. EORTC-related new drug discovery and development activities: role of

the Pharmacology and Molecular Mechanisms Group. European Journal of Cancer 2012; 10: 128-140. (VUmc) 1213. Peters GJ, Giovannetti E. First genome-wide association study to identify novel genes related to irinotecan toxicity.

Pharmacogenomics 2012; 13: 1445-1446. (VUmc) 1214. Peters M, Moman MR, van der Poel HG, Vergunst H, de Jong IJ, Vijverberg PL, et al. Patterns of outcome and toxicity

after salvage prostatectomy, salvage cryosurgery and salvage brachytherapy for prostate cancer recurrences after radiation therapy: a multi-center experience and literature review. World J Urol 2012 (NKI)

1215. Peters MAD, van Drooge AM, Wolkerstorfer A, van Gemert MJC, van der Veen JPW, Bos JD, Beek JF. Double pass 595 nm pulsed dye laser at a 6 minute interval for the treatment of port-wine stains is not more effective than single pass. Lasers In Surgery And Medicine 2012; 44(3): 199-204. (AMC)

1216. Peters MJL, van Sijl AM, Voskuyl AE, Sattar N, Smulders YM, Nurmohamed MT. The Effects of Tumor Necrosis Factor Inhibitors on Cardiovascular Risk in Rheumatoid Arthritis. Current Pharmaceutical Design 2012; 18: 1502-1511. (VUmc)

1217. Peters TTA, Castelijns JA, Ljumanovic R, Witte BI, Leemans CR, de Bree R. Diagnostic value of CT and MRI in the detection of paratracheal lymph node metastasis. Oral Oncology 2012; 48: 450-455. (VUmc)

1218. Peulen H, Hanbeukers B, Boersma L, van Baardwijk A van den Ende P, Houben R, Jager J, Murrer L, Borger J. Forward intensity-modulated radiotherapy planning in breast cancer to improve dose homogeneity: feasibility of class solutions. Int J Radiat Oncol Biol Phys 2012; 82: 394-400 (NKI)

1219. Peuscher MH and Jacobs JJL. Posttranslational control of telomere maintenance and the telomere damage response. Cell Cycle 2012; 11: 1524- 1534 (NKI)

1220. Pham TV, Jimenez CR. An accurate paired sample test for count data. Bioinformatics 2012; 28: I596-I602. (VUmc) 1221. Pham TV, Piersma SR, Oudgenoeg G, Jimenez CR. Label-free mass spectrometry-based proteomics for biomarker

discovery and validation. Expert Review of Molecular Diagnostics 2012; 12: 343-359. (VUmc) 1222. Phernambucq ECJ, Hartemink KJ, Smit EF, Paul MA, Postmus PE, Comans EFI, Senan S. Tumor Cavitation in Patients

With Stage III Non-Small-Cell Lung Cancer Undergoing Concurrent Chemoradiotherapy Incidence and Outcomes. Journal of Thoracic Oncology 2012; 7: 1271-1275. (VUmc)

1223. phytoestrogensulfate transporter in vivo. FASEB 2012; 26: 4014-4024 (NKI) 1224. Piao XH, Komazawa-Sakon S, Nishina T, Koike M, Piao JH, Ehlken H, Kurihara H, Hara M, Van Rooijen N, Schutz G,

Ohmuraya M, Uchiyama Y, Yagita H, Okumura K, He YW, Nakano H. c-FLIP Maintains Tissue Homeostasis by Preventing Apoptosis and Programmed Necrosis. Science Signaling 2012; 5: . (VUmc)

1225. Pieters B, Wijkstra H, van Herk M, Kuipers R, Kaljouw E, de la Rosette J, Koning C. Contrast-enhanced ultrasound as support for prostate brachytherapy treatment planning. Journal Of Contemporary Brachytherapy 2012; 4(2): 69-74. (AMC)

1226. Pieters BR, Horenblas S, Koning CC. Does Partial Cystectomy Compromise Oncologic Outcomes for Patients with Bladder Cancer Compared to Radical Cystectomy? A Matched Case-Control Analysis. J Urol. 2012 (NKI)

1227. Pijpe A, Andrieu N, Easton DF, Kesminiene A, Cardis E, Nogues C, Gauthier-Villars M, Lasset C, Fricker JP, Peock S, Frost D, Evans DG, Eeles RA, Paterson J, Manders P, Van Asperen CJ, Ausems MG, Meijers- Heijboer H, Thierry-Chef I, Hauptmann M, Goldgar D, Rookus MA, Van Leeuwen FE; GENEPSO; EMBRACE; HEBON. Exposure to diagnostic radiation and risk of breast cancer among carriers of BRCA1/2 mutations: retrospective cohort study (GENE-RAD-RISK). BMJ 2012; 345: e5660 (NKI/VUmc/AMC)


1228. Pimentel-Nunes P, Dinis-Ribeiro M, Soares JB, Marcos-Pinto R, Santos C, Rolanda C, Bastos RP, Areia M, Afonso L, Bergman J, Sharma P, Gotoda T, Henrique R, Moreira-Dias L. A multicenter validation of an endoscopic classification with narrow band imaging for gastric precancerous and cancerous lesions. Endoscopy 2012; 44(3): 236-246. (AMC)

1229. Pindyurin AV, van Steensel B. Hox in space: gene cluster regulation linked to folding of chromatin. Nucleus 2012; 3: 118-22 (NKI)

1230. Piriou E, Asito AS, Sumba PO, Fiore N, Middeldorp JM, Moormann AM, Ploutz-Snyder R, Rochford R. Early Age at Time of Primary Epstein-Barr Virus Infection Results in Poorly Controlled Viral Infection in Infants From Western Kenya: Clues to the Etiology of Endemic Burkitt Lymphoma. J Infect Dis 2012; 205: 906-913. (VUmc)

1231. Pisters MF, Veenhof C, van Dijk GM, Heymans MW, Twisk JWR, Dekker J. The course of limitations in activities over 5 years in patients with knee and hip osteoarthritis with moderate functional limitations: risk factors for future functional decline. Osteoarthritis and Cartilage 2012; 20: 503-510. (VUmc)

1232. Ploquin A, Olmos D, Lacombe D, A'Hern R, Duhamel A, Twelves C, Marsoni S, Morales-Barrera R, Soria JC, Verweij J, Voest EE, Schöffski P, Schellens JH, Kramar A, Kristeleit RS, Arkenau HT, Kaye SB, Penel N. Prediction of early death among patients enrolled in phase I trials: development and validation of a new model based on platelet count and albumin. Br J Cancer 2012; 107: 1025-30 (NKI)

1233. Pluim D, Devriese LA, Beijnen JH, Schellens JH. Validation of a multiparameter flow cytometry method for the determination of phosphorylated extracellular-signalregulated kinase and DNA in circulating tumor cells. Cytometry A 2012; 81: 664-71 (NKI)

1234. Poortmans P, Aznar M, Bartelink H. Quality indicators for breast cancer: revisiting historical evidence in the context of technology changes. Semin Radiat Oncol 2012; 22: 29-39 (NKI)

1235. Posfai E, Kunzmann R, Brochard V, Salvaing J, Cabuy E, Roloff TC, Liu Z, Tardat M, van Lohuizen M, Vidal M, Beaujean N, Peters AH. Polycomb function during oogenesis is required for mouse embryonic development. Genes Dev 2012; 1: 26: 920 (NKI)

1236. Pospisilova S, Gonzalez D, Malcikova J, Trbusek M, Rossi D, Kater AP, Cymbalista F, Eichhorst B, Hallek M, Döhner H, Hillmen P, van Oers M, Gribben J, Ghia P, Montserrat E, Stilgenbauer S, Zenz T. ERIC recommendations on TP53 mutation analysis in chronic lymphocytic leukemia. Leukemia 2012; 26(7): 1458-1461. (AMC)

1237. Post ICJH, Dirkes MC, Heger M, Bezemer R, van 't Leven J, van Gulik TM. Optimal flow and pressure management in machine perfusion systems for organ preservation. Annals Of Biomedical Engineering 2012; 40(12): 2698-2707. (AMC)

1238. Post ICJH, Dirkes MC, Heger M, van Loon JPAM, Swildens B, Huijzer GM, van Gulik TM. Appraisal of the porcine kidney autotransplantation model. Frontiers In Bioscience (Elite Edition) 2012; 4: 1345-1357. (AMC)

1239. Postel R, Sonnenberg A. Carbonic anhydrase 5 regulates acid-base homeostasis in zebrafish. PLoS One 2012; 7: e39881 (NKI)

1240. Posthuma de Boer J, van Egmond PW, Helder MN, de Menezes RX, Cleton-Jansen AM, Belien JAM, Verheul HMW, van Royen BJ, Kaspers GJJL, van Beusechem VW. Targeting JNK-interacting protein 1 (JIP1) sensitises osteosarcoma to doxorubicin. Oncotarget 2012; 3: 1169-1181. (VUmc)

1241. Potharst ES, Schuengel C, Last BF, van Wassenaer AG, Kok JH, Houtzager BA. Difference in mother-child interaction between preterm- and term-born preschoolers with and without disabilities. ACTA Paediatrica 2012; 101(6): 597-603. (AMC)

1242. Potharst Eva S., Houtzager Bregje A. , van Sonderen Loekie, Tamminga Pieter, Kok Joke H., Last Bob F., van Wassenaer Aleid G.: Prediction of cognitive abilities at the age of 5 years using developmental follow-up assessments at the age of 2 and 3 years in very preterm children. Developmental Medicine And Child Neurology 2012; 54(3): 240-246. (AMC)

1243. Poyck PPC, Polat F, Gouma DJ, Hesp WLEM. Is biliopancreatic diversion with duodenal switch a solution for patients after laparoscopic gastric banding failure? Surgery For Obesity And Related Diseases 2012; 8(4): 393-399. (AMC)

1244. Prahallad A, Sun C, Huang S, Di Nicolantonio F, Salazar R, Zecchin D, Beijersbergen RL, Bardelli A, Bernards R. Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR. Nature 2012; 483: 100-3 (NKI)

1245. Prapaitrakool S, Hollmann MW, Wartenberg HC, Preckel B, Brugger S. Use of buprenorphine in children with chronic pseudoobstruction syndrome: case series and review of literature. Clinical Journal Of Pain 2012; 28(8): 722-725. (AMC)

1246. Preusser M, Winkler F, Collette L, Haller S, Marreaud S, Soffietti R, Klein M, Reijneveld JC, Tonn JC, Baumert BG, Mulvenna P, Schadendorf D, Duchnowska R, Berghoff AS, Lin N, Cameron DA, Belkacemi Y, Jassem J, Weber DC. Trial design on prophylaxis and treatment of brain metastases: Lessons learned from the EORTC Brain Metastases Strategic Meeting 2012. European Journal of Cancer 2012; 48: 3439-3447. (VUmc)

1247. Prinsen H, Bleijenberg G, Zwarts MJ, Hopman MTE, Heerschap A, van Laarhoven HWM. Physiological and neurophysiological determinants of postcancer fatigue: design of a randomized controlled trial. BMC Cancer 2012; 12(1): 256-. (AMC)

1248. Prinsen H, de Vries IJ, Torensma R, Pots JM, Mulder SF, van Herpen CM, Elving LD, Bleijenberg G, Stelma FF, van Laarhoven HW. Humoral and cellular immune responses after influenza vaccination in patients with chronic fatigue syndrome. BMC Immunology 2012; 13(1): 71-. (AMC)

1249. Prytula AA, Bouts AH, Mathot RAA, van Gelder T, Croes LK, Hop W, Cransberg K. Intra-patient variability in tacrolimus trough concentrations and renal function decline in pediatric renal transplant recipients. Pediatric Transplantation 2012; 16(6): 613-618. (AMC)

1250. Punt CJA. Bevacizumab voor gemetastaseerd colorectaalcarcinoom in de dagelijkse praktijk. Nederlands Tijdschrift Voor Oncologie 2012; 9: 54-56. (AMC)

1251. Qiu HY, KuoLee R, Harris G, Van Rooijen N, Patel GB, Chen WX. Role of Macrophages in Early Host Resistance to Respiratory Acinetobacter baumannii Infection. PloS one 2012; 7: e40019. (VUmc)

1252. Queiroz KCS, Bijlsma MF, Tio RA, Zeebregts CJ, Dunaeva M, Ferreira CV, Fuhler GM, Kuipers EJ, Alves MM, Rezaee F, Spek CA, Peppelenbosch MP. Dichotomy in Hedgehog signaling between human healthy vessel and atherosclerotic plaques. Molecular Medicine 2012; 18(7): 1122-1127. (AMC)

1253. Queiroz KCS, Milani R, Ruela-de-Sousa RR, Fuhler GM, Justo GZ, Zambuzzi WF, Duran N, Diks SH, Spek CA, Ferreira CV, Peppelenbosch MP. Violacein induces death of resistant leukaemia cells via kinome reprogramming, endoplasmic reticulum stress and Golgi apparatus collapse. Plos One 2012; 7(10): e45362-. (AMC)


1254. Queiroz KCS, Spek CA, Peppelenbosch MP. Targeting Hedgehog signaling and understanding refractory response to treatment with Hedgehog pathway inhibitors. Drug Resistance Updates 2012; 15(4): 211-222. (AMC)

1255. Quik EH, Valk GD, Drent ML, Stalpers LJA, Kenemans JL, Koppeschaar HPF, van Dam PS. Reduced growth hormone secretion after cranial irradiation contributes to neurocognitive dysfunction. Growth Hormone & Igf Research 2012; 22(1): 42-47. (AMC)

1256. Raaijmakers JA, van Heesbeen RG, Meaders JL, Geers EF, Fernandez- Garcia B, Medema RH and Tanenbaum ME. Nuclear envelope-associated dynein drives prophase centrosome separation and enables Eg5- independent bipolar spindle formation. EMBO J 2012; 31: 4179-90 (NKI)

1257. Raber-Durlacher JE, Brennan MT, Verdonck-de Leeuw IM, Gibson RJ, Eilers JG, Waltimo T, Bots CP, Michelet M, Sollecito TP, Rouleau TS, Sewnaik A, Bensadoun RJ, Fliedner MC, Silverman SJ, Spijkervet FKL. Swallowing dysfunction in cancer patients. Supportive Care in Cancer 2012; 20: 433-443. (VUmc)

1258. Rabinovich GA, van Kooyk Y, Cobb BA. Glycobiology of immune responses. Glycobiology of the Immune Response 2012; 1253: 1-15. (VUmc)

1259. Rachmadi L, Jordanova ES, Kolkman-Uljee S, van der Linden-Narain I, Purwoto G, Siregar B, Fleuren GJ, Cornain S, Veselic M. Cytomorphological Analysis of Uterine Cervical Pap Smears in Relation to Human Papillomavirus Infection in Indonesian Women. Acta Cytologica 2012; 56: 171-176. (VUmc)

1260. Radchenko V, Hauser H, Eisenhut M, Vugts DJ, van Dongen GAMS, Roesch F. Nb-90 - a potential PET nuclide: production and labeling of monoclonal antibodies. Radiochimica Acta 2012; 100: 857-863. (VUmc)

1261. Rades D, Douglas S, Veninga T, Bajrovic A, Stalpers LJA, Hoskin PJ, Rudat V, Schild SE. A survival score for patients with metastatic spinal cord compression from prostate cancer. Strahlentherapie Und Onkologie 2012; 188(9): 802-806. (AMC)

1262. Rades D, Douglas S, Veninga T, Bajrovic A, Stalpers LJA, Hoskin PJ, Rudat V, Schild SE. Metastatic spinal cord compression in non-small cell lung cancer patients. Prognostic factors in a series of 356 patients. Strahlentherapie Und Onkologie 2012; 188(6): 472-476. (AMC)

1263. Rades D, Douglas S, Veninga T, Stalpers LJA, Bajrovic A, Rudat V, Schild SE. Prognostic factors in a series of 504 breast cancer patients with metastatic spinal cord compression. Strahlentherapie Und Onkologie 2012; 188(4): 340-345. (AMC)

1264. Radman-Livaja M, Quan TK, Valenzuela L, Armstrong JA, Van Welsem T, Kim TS, Lee KJ, Buratowski S, van Leeuwen F, Rando OJ, Harzorg, GA A Key Role for Chd1 in Histone H3 Dynamics at the 3’ Ends of Long Genes in Yeast. PLoS Genetics 2012; 8: e1002811 (NKI)

1265. Radner S, Celie PH, Fuchs K, Sieghart W, Sixma TK, Stornaiuolo M. Transient transfection coupled to baculovirus infection for rapid protein expression screening in insect cells. J Struct Biol 2012; 179: 46-55 (NKI)

1266. Raghwani J, Thomas XV, Koekkoek SM, Schinkel J, Molenkamp R, van de Laar TJ, Takebe Y, Tanaka Y, Mizokami M, Rambaut A, Pybus OG. Origin and Evolution of the Unique Hepatitis C Virus Circulating Recombinant Form 2k/1b. Journal of Virology 2012; 86: 2212-2220. (VUmc)

1267. Rahner N, Brockschmidt FF, Steinke V, Kahl P, Becker T, Vasen HF, Wijnen JT, Tops CJ, Holinski-Feder E, Ligtenberg MJ, Spruijt L, Goergens H, Stemmler S, Kloor M, Dietmaier W, Schumacher J, Noethen MM, Propping P. Mutation and association analyses of the candidate genes ESR1, ESR2, MAX, PCNA, and KAT2A in patients with unexplained MSH2-deficient tumors. Familial Cancer 2012; 11: 19-26. (VUmc)

1268. Rajan A, Sullivan R, Bakker S, Van Harten WH Critical appraisal of translational research models for suitability in performance assessment of cancer centers. The Oncologist 2012; 17: e48-57 (NKI)

1269. Rakhmilevich AL, Baldeshwiler MJ, Van De Voort TJ, Felder MAR, Yang RK, Kalogriopoulos NA, Koslov DS, Van Rooijen N, Sondel PM. Tumor-associated myeloid cells can be activated in vitro and in vivo to mediate antitumor effects. Cancer Immunology Immunotherapy 2012; 61: 1683-1697. (VUmc)

1270. Ram K, Dam L, in 't Hof KH, Nieveen van Dijkum EJM. Intraoperatieve neuromonitoring bij endocriene chirurgie. Nederlands Tijdschrift Voor Geneeskunde 2012; 156(25): A4483-. (AMC)

1271. Ramus SJ, Antoniou AC, Kuchenbaecker KB, Soucy P, Beesley J, Chen X, McGuffog L, Sinilnikova OM, Healey S, Barrowdale D, Lee A, Thomassen M, Gerdes A, Kruse TA, Jensen UB, Skytte A, Caligo MA, Liljegren A, Lindblom A, Olsson H, Kristoffersson U, Stenmark-Askmalm M, Melin B, Domchek SM, Nathanson KL, Rebbeck TR, Jakubowska A, Lubinski J, Jaworska K, Durda K, Złowocka E, Gronwald J, Huzarski T, Byrski T, Cybulski C, Toloczko-Grabarek A, Osorio A, Benitez J, Duran M, Tejada M, Hamann U, Rookus M, van Leeuwen FE, Aalfs CM, Meijers-Heijboer HEJ, van Asperen CJ, van Roozendaal KEP, Hoogerbrugge N, Collée JM, Kriege M, van der Luijt RB, Peock S, Frost D, Ellis SD, Platte R, Fineberg E, Evans DG, Lalloo F, Jacobs C, Eeles R, Adlard J, Davidson R, Eccles D, Cole T, Cook J, Paterson J, Douglas F, Brewer C, Hodgson S, Morrison PJ, Walker L, Porteous ME, Kennedy MJ, Pathak H, Godwin AK, Stoppa-Lyonnet D, Caux-Moncoutier V, de Pauw A, Gauthier-Villars M, Mazoyer S, Léoné M, Calender A, Lasset C, Bonadona V, Hardouin A, Berthet P, Bignon Y, Uhrhammer N, Faivre L, Loustalot C, Buys S, Daly M, Miron A, Terry MB, Chung WK, John EM, Southey M, Goldgar D, Singer CF, Muy-Kheng T, Pfeiler G, Fink-Retter A, Hansen TVO, Ejlertsen B, Johannsson OT, Offit K, Kirchhoff T, Gaudet MM, Vijai J, Robson M, Piedmonte M, Phillips K, van Le L, Hoffman JS, Ewart Toland A, Montagna M, Tognazzo S, Imyanitov E, Issacs C, Janavicius R, Lazaro C, Blanco I, Tornero E, Navarro M, Moysich KB, Karlan BY, Gross J, Olah E, Vaszko T, Teo SH, Ganz PA, Beattie MS, Dorfling CM, van Rensburg EJ, Diez O, Kwong A, Schmutzler RK, Wappenschmidt B, Engel C, Meindl A, Ditsch N, Arnold N, Heidemann S, Niederacher D, Preisler-Adams S, Gadzicki D, Varon-Mateeva R, Deissler H, Gehrig A, Sutter C, Kast K, Fiebig B, Schäfer D, Caldes T, de la Hoya M, Nevanlinna H, Aittomäki K, Plante M, Spurdle AB, Neuhausen SL, Ding YC, Wang X, Lindor N, Fredericksen Z, Pankratz VS, Peterlongo P, Manoukian S, Peissel B, Zaffaroni D, Bonanni B, Bernard L, Dolcetti R, Papi L, Ottini L, Radice P, Greene MH, Mai PL, Andrulis IL, Glendon G, Ozcelik H, Pharoah PDP, Gayther SA, Simard J, Easton DF, Couch FJ, Chenevix-Trench G. Ovarian cancer susceptibility alleles and risk of ovarian cancer in BRCA1 and BRCA2 mutation carriers. Human Mutation 2012; 33(4): 690-702. (AMC/NKI)

1272. Raterman HG, Nurmohamed MT. Hypothyroidism in Rheumatoid Arthritis - To Screen or Not to Screen?. Journal of Rheumatology 2012; 39: 885-886. (VUmc)

1273. Raterman HG, Vosslamber S, de Ridder S, Nurmohamed MT, Lems WF, Boers M, van de Wiel MA, Dijkmans BAC, Verweij CL, Voskuyl AE. The interferon type I signature towards prediction of non-response to rituximab in rheumatoid arthritis patients. Arthritis Research & Therapy 2012; 14: R95. (VUmc)

1274. Rausch T, Jones DTW, Zapatka M, Stütz AM, Zichner T, Weischenfeldt J, Jäger N, Remke M, Shih D, Northcott PA, Pfaff E, Tica J, Wang Q, Massimi L, Witt H, Bender S, Pleier S, Cin H, Hawkins C, Beck C, von Deimling A, Hans V, Brors B, Eils R, Scheurlen W, Blake J, Benes V, Kulozik AE, Witt O, Martin D, Zhang C, Porat R, Merino DM, Wasserman


J, Jabado N, Fontebasso A, Bullinger L, Rücker FG, Döhner K, Döhner H, Koster J, Molenaar JJ, Versteeg R, Kool M, Tabori U, Malkin D, Korshunov A, Taylor MD, Lichter P, Pfister SM, Korbel JO. Genome sequencing of pediatric medulloblastoma links catastrophic DNA rearrangements with TP53 mutations. Cell 2012; 148(1-2): 59-71. (AMC)

1275. Rayson D, Suter TM, Jackisch C, van der Vegt S, Bermejo B, van den Bosch J, Vivanco GL, van Gent AM, Wildiers H, Torres A, Provencher L, Temizkan M, Chirgwin J, Canon JL, Ferrandina G, Srinivasan S, Zhang L, Richel DJ. Cardiac safety of adjuvant pegylated liposomal doxorubicin with concurrent trastuzumab: a randomized phase II trial. Annals Of Oncology 2012; 23(7): 1780-1788. (AMC)

1276. Rebers S, van der Valk T, Meijer GA, van Leeuwen FE and Schmidt MK. De toekomst van zeggenschap bij nader gebruik van lichaamsmateriaal: in het belang van de patient? [Consent for the secondary use of human residual tissue: the patient is best served by an ‘opting-out’ procedure]. Ned Tijdschr Geneeskd 2012; 156: A4485 (NKI)

1277. Recher M, Burns SO, de la Fuente MA, Volpi S, Dahlberg C, Walter JE, Moffitt K, Mathew D, Honke N, Lang PA, Patrizi L, Falet H, Keszei M, Mizui M, Csizmadia E, Candotti F, Nadeau K, Bouma G, Delmonte OM, Frugoni F, Fomin AB, Buchbinder D, Lundequist EM, Massaad MJ, Tsokos GC, Hartwig J, Manis J, Terhorst C, Geha RS, Snapper S, Lang KS, Malley R, Westerberg L, Thrasher AJ, Notarangelo LD. B cell-intrinsic deficiency of the Wiskott-Aldrich syndrome protein (WASp) causes severe abnormalities of the peripheral B-cell compartment in mice. Blood 2012; 119: 2819-2828. (VUmc)

1278. Reck M, Thatcher N, Smit EF, Lorigan P, Szutowicz-Zielinska E, Liepa AM, Winfree KB, Peterson P, Guba SC, Socinski MA. Baseline quality of life and performance status as prognostic factors in patients with extensive-stage disease small cell lung cancer treated with pemetrexed plus carboplatin vs. etoposide plus carboplatin. Lung Cancer 2012; 78: 276-281. (VUmc)

1279. Reeve BB, Wyrwich KW, Wu AW, Velikova G, Terwee CB, Snyder CF, Schwartz C, Revicki DA, Moinpour CM, McLeod LD, Lyons JC, Lenderking WR, Hinds Ps, Hays RD, Greenhalgh J, Gershon R, Feeny D, Fayers PM, Cella D, Brundage M, Ahmed S, Aaronson NK, Butt Z on behalf of the International Society for Quality of Life Research (ISOQOL). ISOQOL recommends minimum standards for patientreported Outcome Measures Used in Patient-Centered Outcomes Research. Qual Life Res 2013 (NKI)

1280. Reijneveld JC, Klein M, Taphoorn MJB, Postma TJ, Heimans JJ. Improved, personalized treatment of glioma necessitates long-term follow-up of cognitive functioning. Pharmacogenomics 2012; 13: 1667-1669. (VUmc)

1281. Reiniers MJ, van Golen RF, van Gulik TM, Heger M. 2',7'-Dichlorofluorescein is not a probe for the detection of reactive oxygen and nitrogen species. Journal Of Hepatology 2012; 56(5): 1214-6; author reply 1216-7. (AMC)

1282. Reneman L, de Win MML, Booij J, van den Brink W, den Heeten GJ, Freling N, Majoie CBLM. Incidental Head and Neck Findings on MRI in Young Healthy Volunteers: Prevalence and Clinical Implications. American Journal Of Neuroradiology 2012; 33(10): 1971-1974. (AMC)

1283. Retel VP, Joore MA, Linn SC, Rutgers EJ, van Harten WH. Scenario drafting to anticipate future developments in technology assessment. BMC Research Notes 2012; 5: 442 (NKI)

1284. Retel VP, Joore MA, Van Harten WH. Head-to-head comparison of the 70-gene signature versus the 21-gene assay: Cost-effectiveness and the effect of compliance. Breast Cancer Res Treat 2012; 131: 627-36 (NKI)

1285. Retel VP, van der Molen L, Hilgers FJ, Rasch CR, L’Ortye AA, Steuten LMR, Van Harten WH A Cost-effectiveness analysis of a preventive exercise program for patients with advanced head and neck cancer treated with concomitant chemo-radiotherapy. BMC Cancer.2011; 11: 475 (NKI)

1286. Reuwer AQ, Nowak-Sliwinska P, Mans LA, van der Loos CM, von der Thusen JH, Twickler MTB, Spek CA, Goffin V, Griffioen AW, Borensztajn KS. Functional consequences of prolactin signalling in endothelial cells: a potential link with angiogenesis in pathophysiology?. Journal of Cellular and Molecular Medicine 2012; 16: 2035-2048. (AMC/VUmc)

1287. Revicki DA, van den Eertwegh AJM, Lorigan P, Lebbe C, Linette G, Ottensmeier CH, Safikhani S, Messina M, Hoos A, Wagner S, Kotapati S. Health related quality of life outcomes for unresectable stage III or IV melanoma patients receiving ipilimumab treatment. Health and Quality of Life Outcomes 2012; 10: . (VUmc)

1288. Reyners AKL, de Munck L, Erdkamp FLG, Smit WM, Hoekman K, Lalisang RI, de Graaf H, Wymenga ANM, Polee M, Hollema H, van Vugt MATM, Schaapveld M, Willemse PHB. A randomized phase II study investigating the addition of the specific COX-2 inhibitor celecoxib to docetaxel plus carboplatin as first-line chemotherapy for stage IC to IV epithelial ovarian cancer, Fallopian tube or primary peritoneal carcinomas: the DoCaCel study. Annals of Oncology 2012; 23: 2896-2902. (VUmc)

1289. Ribeiro-Viana R, Garcia-Vallejo JJ, Collado D, Perez-Inestrosa E, Bloern K, van Kooyk Y, Rojo J. BODIPY-Labeled DC-SIGN-Targeting Glycodendrons Efficiently Internalize and Route to Lysosomes in Human Dendritic Cells. Biomacromolecules 2012; 13: 3209-3219. (VUmc)

1290. Rigaill GJ, Cadot S, Kluin RJ, Xue Z, Bernards R, Majewski IJ, Wessels LF. A regression model for estimating DNA copy number applied to capture sequencing data. Bioinformatics 2012; 28: 2357-65 (NKI)

1291. Rijkaart DC, Berkhof J, Rozendaal L, van Kemenade FJ, Bulkmans NWJ, Heideman DAM, Kenter GG, Cuzick J, Snijders PJF, Meijer CJLM. Human papillomavirus testing for the detection of high-grade cervical intraepithelial neoplasia and cancer: final results of the POBASCAM randomised controlled trial. Lancet Oncology 2012; 3(1): 78-88. (VUmc/AMC/NKI)

1292. Rijkaart DC, Berkhof J, van Kemenade FJ, Coupe VMH, Hesselink AT, Rozendaal L, Heideman DAM, Verheijen RH, Bulk S, Verweij WM, Snijders PJF, Meijer CJLM. Evaluation of 14 triage strategies for HPV DNA-positive women in population-based cervical screening. International Journal of Cancer 2012; 130: 602-610. (VUmc)

1293. Rijkaart DC, Berkhof J, van Kemenade FJ, Coupe VMH, Rozendaal L, Heideman DAM, Verheijen RHM, Bulk S, Verweij W, Snijders PJF, Meijer CJLM. HPV DNA testing in population-based cervical screening (VUSA-Screen study): results and implications. Br J Cancer 2012; 106: 975-981. (VUmc)

1294. Rijkaart DC, Heideman DAM, Coupe VMH, Brink AATP, Verheijen RHM, Skomedal H, Karlsen F, Morland E, Snijders PJF, Meijer CJLM. High-Risk Human Papillomavirus (hrHPV) E6/E7 mRNA Testing by PreTect HPV-Proofer for Detection of Cervical High-Grade Intraepithelial Neoplasia and Cancer among hrHPV DNA-Positive Women with Normal Cytology. Journal of Clinical Microbiology 2012; 50: 2390-2396. (VUmc)

1295. Rit S, van Herk M, Zijp L, JJ Sonke. Quantifications of the variability of diaphragm motion and implications for treatment margin Construction. Int J Radiat Oncol Biol Phys 2012; 82: e399- 407 (NKI)

1296. Ritsma L, Steller EJ, Beerling E, Loomans CJ, Zomer A, Gerlach C, Vrisekoop N, Seinstra D, van Gurp L, Schafer R, Raats DA, de Graaff A, Schumacher TN, de Koning EJ, Rinkes IH, Kranenburg O, Rheenen J. Intravital microscopy through an abdominal imaging window reveals a pre-micrometastasis stage during liver metastasis. Sci Transl Med 2012; 4: 158ra145 (NKI)


1297. Rizvi SNF, Visser OJ, Vosjan MJWD, van Lingen A, Hoekstra OS, Zijlstra JM, Huijgens PC, van Dongen GAMS, Lubberink M. Biodistribution, radiation dosimetry and scouting of Y-90-ibritumomab tiuxetan therapy in patients with relapsed B-cell non-Hodgkin's lymphoma using Zr-89-ibritumomab tiuxetan and PET. European Journal of Nuclear Medicine and Molecular Imaging 2012; 39: 512-520. (VUmc)

1298. Rizzi TS, Beunders G, Rizzu P, Sistermans E, Twisk JWR, van Mechelen W, Deijen JB, Meijers-Heijboer H, Verhage M, Heutink P, Posthuma D. Supporting the generalist genes hypothesis for intellectual ability/disability: the case of SNAP25. Genes Brain And Behavior 2012; 11(7): 767-771. (AMC)

1299. Robbins CS, Chudnovskiy A, Rauch PJ, Figueiredo JL, Iwamoto Y, Gorbatov R, Etzrodt M, Weber GF, Ueno T, Van Rooijen N, Mulligan-Kehoe MJ, Libby P, Nahrendorf M, Pittet MJ, Weissleder R, Swirski FK. Extramedullary Hematopoiesis Generates Ly-6C(high) Monocytes That Infiltrate Atherosclerotic Lesions. Circulation 2012; 125: 364-U415. (VUmc)

1300. Rodjan F, de Graaf P, Brisse HJ, Goricke S, Maeder P, Galluzzi P, Aerts I, Alapetite C, Desjardins L, Wieland R, Popovic MB, Diezi M, Munier FL, Hadjistilianou T, Knol DL, Moll AC, Castelijns JA. Trilateral retinoblastoma: neuroimaging characteristics and value of routine brain screening on admission. Journal of Neuro-Oncology 2012; 109: 535-544. (VUmc)

1301. Rodjan F, de Graaf P, van der Valk P, Moll AC, Kuijer JPA, Knol DL, Castelijns JA, Pouwels PJW. Retinoblastoma: Value of Dynamic Contrast-Enhanced MR Imaging and Correlation with Tumor Angiogenesis. AJNR American Journal of Neuroradiology 2012; 33: 2129-2135. (VUmc)

1302. Rodrigo JP, Garcia-Pedrero JM, Suarez C, Takes RP, Thompson LDR, Slootweg PJ, Woolgar JA, Westra WH, Brakenhoff RH, Rinaldo A, Devaney KO, Williams MD, Gnepp DR, Ferlito A. Biomarkers predicting malignant progression of laryngeal epithelial precursor lesions: a systematic review. European Archives of Oto-Rhino-Laryngology 2012; 269: 1073-1083. (VUmc)

1303. Rodrigues G, Eppinga W, Lagerwaard F, de Haan P, Haasbeek C, Perera F, Slotman B, Yaremko B, Yartsev S, Bauman G. A pooled analysis of arc-based image-guided simultaneous integrated boost radiation therapy for oligometastatic brain metastases. Radiotherapy and Oncology 2012; 102: 180-186. (VUmc)

1304. Rodrigues G, Yartsev S, Tay KY, Pond GR, Lagerwaard F, Bauman G. A phase II multi-institutional study assessing simultaneous in-field boost helical tomotherapy for 1-3 brain metastases. Radiation Oncology 2012; 7: . (VUmc)

1305. Roelofs E, Engelsman M, Rasch C, Persoon L, Qamhiyeh S, de Ruysscher D, Verhaegen F, Pijls-Johannesma M, Lambin P; ROCOCO Consortium. Results of a multicentric in silico clinical trial (ROCOCO): comparing radiotherapy with photons and protons for nonsmall cell lung cancer. J Thorac Oncol 2012; 7: 165-76 (NKI)

1306. Roelofsen T, van Ham MA, Wiersma van Tilburg JM, Zomer SF, Bol M, Massuger LF, Bulten J. Pure compared with mixed serous endometrial carcinoma: two different entities? Obstet Gynecol 2012; 120: 1371-1381 (NKI)

1307. Roestenberg M, de Vlas SJ, Nieman AE, Sauerwein RW, Hermsen CC. Efficacy of Preerythrocytic and Blood-Stage Malaria Vaccines Can Be Assessed in Small Sporozoite Challenge Trials in Human Volunteers. J Infect Dis 2012; 206: 319-323. (VUmc)

1308. Rohof WO, Bennink RJ, de Ruigh AA, Hirsch DP, Zwinderman AH, Boeckxstaens GE. Effect of azithromycin on acid reflux, hiatus hernia and proximal acid pocket in the postprandial period. GUT 2012; 61(12): 1670-1677. (AMC)

1309. Ronco G, Biggeri A, Confortini M, Naldoni C, Segnan N, Sideri M, Zappa M, Zorzi M, Calvia M, Accetta G, Giordano L, Cogo C, Carozzi F, Gillio Tos A, Arbyn M, Meijer CJLM, Snijders PJF, Cuzick J, Giorgi Rossi P. Health Technology assessment Report: Ricerca del dna di papillomavirus umano (HPV) come test primario per lo screening dei precursori del cancro del collo dell'utero.. Epidemiologia e Prevenzione 2012; 36: 1-72. (VUmc)

1310. Ronco G, Meijer CJ, Cuzick J, Giorgi-Rossi P, Peto J, Segnan N, Dillner J. Screening for Cervical Cancer. Annals of Internal Medicine 2012; 156: 604-605. (VUmc)

1311. Rooswinkel RW, Van de Kooij B, Verheij M, Borst J. Bcl-2 is a better ABT-737 target than Bcl-xL or Bcl-w and only Noxa overcomes resistance mediated by Mcl-1, Bfl-1, or Bcl-B. Cell Death Dis 2012; 3: e366 * and **Equal contribution (NKI)

1312. Rosati A, Bersani S, Tavano F, Dalla Pozza E, de Marco M, Palmieri M, de Laurenzi V, Franco R, Scognamiglio G, Palaia R, Fontana A, di Sebastiano P, Donadelli M, Dando I, Medema JP, Dijk F, Welling L, di Mola FF, Pezzilli R, Turco MC, Scarpa A. Expression of the antiapoptotic protein BAG3 is a feature of pancreatic adenocarcinoma and its overexpression is associated with poorer survival. American Journal Of Pathology 2012; 181(5): 1524-1529. (AMC)

1313. Rosetti F, Tsuboi N, Chen K, Nishi H, Ernandez T, Sethi S, Croce K, Stavrakis G, cocer-Varela J, Gomez-Martin D, Van Rooijen N, Kyttaris VC, Lichtman AH, Tsokos GC, Mayadas TN. Human Lupus Serum Induces Neutrophil-Mediated Organ Damage in Mice That Is Enabled by Mac-1 Deficiency. J Immunol 2012; 189: 3714-3723. (VUmc)

1314. Rositch AF, Hudgens MG, Backes DM, Moses S, Agot K, Nyagaya E, Snijders PJF, Meijer CJLM, Bailey RC, Smith JS. Vaccine-Relevant Human Papillomavirus (HPV) Infections and Future Acquisition of High-Risk HPV Types in Men. Journal of Infectious Diseases 2012; 206: 669-677. (VUmc)

1315. Rositch AF, Poole C, Hudgens MG, Agot K, Nyagaya E, Moses S, Snijders PJF, Meijer CJLM, Bailey RC, Smith JS. Multiple Human Papillomavirus Infections and Type Competition in Men. J Infect Dis 2012; 205: 72-81. (VUmc)

1316. Rosmarin DM, Carette JE, Olive AJ, Starnbach MN, Brummelkamp TR, Ploegh HL. Attachment of Chlamydia trachomatis L2 to host cells requires sulfation. Proc Natl Acad U S A 2012; 25,10059-64 (NKI)

1317. Rottenberg S*, Jonkers J*. MEK inhibition as a strategy for targeting residual breast cancer cells with low DUSP4 expression. Breast Cancer Res 2012; 14: 324 (* joint corresponding authors) (NKI) (NKI)

1318. Rottenberg S, Borst P. Drug resistance in the mouse cancer clinic. Drug Resistance Updates 2012; 15(1-2): 81-89. (NKI/AMC)

1319. Rottenberg S, Vollebergh MA, de Hoon B, de Ronde J, Schouten PC, Kersbergen A, Zander SAL, Pajic Marina, Jaspers JE, Jonkers M, Lodén M, Sol W, van der Burg E, Wesseling J, Gillet J, Gottesman MM, Gribnau J, Wessels L, Linn SC, Jonkers J, Borst P. Impact of intertumoral heterogeneity on predicting chemotherapy response of BRCA1-deficient mammary tumors. Cancer Research 2012; 72(9): 2350-2361. (NKI/AMC)

1320. Rucktooa P, Haseler CA, van Elk R, Smit AB, Gallagher T, Sixma TK. Structural characterization of binding mode of smoking cessation drugs to nicotinic acetylcholine receptors through study of ligand complexes with acetylcholine-binding protein. J Biol Chem 2012; 287: 23283-93 (NKI)

1321. Ruers T, Punt C, Van Coevorden F, Pierie JP, Borel-Rinkes I, Ledermann JA, Poston G, Bechstein W, Lentz MA, Mauer M, Van Cutsem E, Lutz MP, Nordlinger B; EORTC Gastro-Intestinal Tract Cancer Group, Arbeitsgruppe Lebermetastasen und—tumoren in der Chirurgischen Arbeitsgemeinschaft Onkologie (ALM-CAO) and the National Cancer Research Institute Colorectal Clinical Study Group (NCRI CCSG. Radiofrequency ablation combined with systemic treatment


versus systemic treatment alone in patients with nonresectable colorectal liver metastases: a randomized EORTC Intergroup phase II study (EORTC 40004). Ann Oncol 2012; 23: 2619-26 (AMC/NKI)

1322. Ruers TJ, Hagendoorn J. Treatment dilemmas in patients with synchronous colorectal liver metastases. Recent Results Cancer Res 2012; 196: 37-49 (NKI)

1323. Ruiterkamp J, Voogd AC, Tjan-Heijnen VC, Bosscha K, van der Linden YM, Rutgers EJT, Boven E, van der Sangen MJ, Ernst MF; Dutch Breast Cancer Trialists’ Group (BOOG). Systemic therapy with or without up front surgery of the primary tumor in breast cancer patients with distant metastases at initial presentation. BMC Surg 2012; 12: 5 (NKI/VUmc)

1324. Rüschoff J, Hanna W, Bilous M, Hofmann M, Osamura RY, Penault-Llorca F, van de Vijver M, Viale G. HER2 testing in gastric cancer: a practical approach. Modern Pathology 2012; 25(5): 637-650. (AMC)

1325. Russo G, Mischi M, Scheepens W, de la Rosette JJ, Wijkstra H. Angiogenesis in prostate cancer: onset, progression and imaging. BJU International 2012; 110(11C): E794-E808. (AMC)

1326. Rutgers EJT. How can breastconserving surgery be improved even more?. Ned Tijdschr Geneeskd 2012; 156 (NKI 1327. Rutten MJ, Gaarenstroom KN, Van Gorp T, van Meurs HS, Arts HJ, Bossuyt PM, Ter Brugge HG, Hermans RH, Opmeer

BC, Pijnenborg JM, Schreuder HW, Schutter EM, Spijkerboer AM, Wensveen CW, Zusterzeel P, Mol BW, Kenter GG, Buist MR. Laparoscopy to predict the result of primary cytoreductive surgery in advanced ovarian cancer patients (LapOvCa-trial): a multicentre randomized controlled study. BMC Cancer 2012; 12: 31. (VUmc/AMC/NKI)

1328. Ruys AT, Busch OR, Gouma DJ, van Gulik TM. Staging Laparoscopy for Hilar Cholangiocarcinoma: Is it Still Worthwhile? Indian Journal Of Surgical Oncology 2012; 3(2): 147-153. (AMC)

1329. Ruys AT, van Haelst S, Busch OR, Rauws EA, Gouma DJ, van Gulik TM. Long-term survival in hilar cholangiocarcinoma also possible in unresectable patients. World Journal Of Surgery 2012; 36(9): 2179-2186. (AMC)

1330. Rygiel TP, Karnam G, Goverse G, van der Marel APJ, Greuter MJ, van Schaarenburg RA, Visser WF, Brenkman AB, Molenaar R, Hoek RM, Mebius RE, Meyaard L. CD200-CD200R signaling suppresses anti-tumor responses independently of CD200 expression on the tumor. Oncogene 2012; 31: 2979-2988. (VUmc)

1331. Saadatmand S, Rutgers EJT, Tollenaar RA, Zonderland HM, Ausems MG, Keymeulen KB, Schlooz-Vries MS, Koppert LB, Heijnsdijk EA, Seynaeve C, Verhoef C, Oosterwijk JC, Obdeijn IM, de Koning HJ, Tilanus-Linthorst MM. Breast density as indicator for the use of mammography or MRI to screen women with familial risk for breast cancer (FaMRIsc): a multicentre randomized controlled trial. BMC Cancer 2012; 12: 440 (NKI)

1332. Sachs N, Claessen N, Aten J, Kreft M, Teske GJ, Koeman A, Zuurbier CJ, Janssen H, Sonnenberg A. Blood pressure influences end-stage renal disease of Cd151 knockout mice. J Clin Invest 2012; 122: 348-58 (NKI)

1333. Sachs N, Secades P, van Hulst L, Kreft M, Song J-Y, Sonnenberg A. Loss of integrin a3 prevents skin tumor formation by promoting epidermal turnover and depletion of slowcycling cells. Proc Natl Acad Sci USA 2012; 109: 21468-73 (NKI)

1334. Sadeghi R, Gholami H, Zakavi SR, Kakhki VR, Horenblas S. Accuracy of 18F-FDG PET/CT for diagnosing inguinal lymph node involvement in penile squamous cell carcinoma: systematic review and meta-analysis of the literature. Clinical nuclear medicine 2012; 37: 436-41 (NKI)

1335. Saeland E, Belo AI, Mongera S, van Die I, Meijer GA, van Kooyk Y. Differential glycosylation of MUC1 and CEACAM5 between normal mucosa and tumour tissue of colon cancer patients. International Journal of Cancer 2012; 131: 117-128. (VUmc)

1336. Sairam K, Scoffone CM, Alken P, Turna B, Sodha HS, Rioja J, Wolf Jr. JS, de La Rosette JJMCH. Percutaneous nephrolithotomy and chronic kidney disease: results from the CROES PCNL Global Study. Journal Of Urology 2012; 188(4): 1195-1200. (AMC)

1337. Salih DAM, Rashid AJ, Colas D, de la Torre-Ubieta L, Zhu RP, Morgan AA, Santo EE, Ucar D, Devarajan K, Cole CJ, Madison DV, Shamloo M, Butte AJ, Bonni A, Josselyn SA, Brunet A. FoxO6 regulates memory consolidation and synaptic function. Genes & Development 2012; 26(24): 2780-2801. (AMC)

1338. Salinas GF, Krausz S, Dontje W, Evavold BD, Tak PP, Baeten DL, Reedquist KA. Sustained Rap1 activation in autoantigen-specific T lymphocytes attenuates experimental autoimmune encephalomyelitis. Journal Of Neuroimmunology 2012; 250(1-2): 35-43. (AMC)

1339. Salm LP, Van der Hiel B, Stokkel MP. Increasing importance of 18F-FDG PET in the diagnosis of neurolymphomatosis. Nucl Med Commun 2012; 33: 907-16 (NKI)

1340. Salm LP, Van der Hiel B, Stokkel MP. Neurolymphomatosis Diagnosed by 18F-FDG PET-CT. Clin Nucl Med. 2012 (NKI) 1341. Samant S, van den Brekel MW, Kies MS, Wan J, Robbins KT, Rosenthal DI, Rasch C, Weber RS. Concurrent

chemoradiation for adenoid cystic carcinoma of the head and neck. HEAD AND NECK-JOURNAL FOR The Sciences And Specialties Of The Head And Neck 2012; 34(9): 1263-1268. (AMC/NKI)

1342. Sanabria A, Kowalski LP, Bradley PJ, Hartl DM, Bradford CR, de Bree R, Rinaldo A, Ferlito A. Sternocleidomastoid muscle flap in preventing Frey's syndrome after parotidectomy: A systematic review. Head and Neck-Journal for the Sciences and Specialties of the Head and Neck 2012; 34: 589-598. (VUmc)

1343. Sanders MS, van Well GTJ, Ouburg S, Morre SA, van Furth AM. Toll-like receptor 9 polymorphisms are associated with severity variables in a cohort of meningococcal meningitis survivors. BMC Infectious Diseases 2012; 12: . (VUmc)

1344. Sanders SJWJ, Bijleveld YA, Kemper EM, Lie-A-Huen L, Mathot RAA. Evaluatie van de doseerrichtlijn voor vancomycine bij kinderen met kanker. Pharmaceutisch Weekblad 2012; 147(24): 99-102. (AMC)

1345. Sanduleanu S, Masclee AM, Meijer GA. Interval cancers after colonoscopy-insights and recommendations. Nature Reviews Gastroenterology & Hepatology 2012; 9: 550-554. (VUmc)

1346. Santana Sosa E, Groeneveld IF, Gonzalez-Saiz L, López-Mojares LM, Villa-Asensi JR, Gonzalez Barrio MI, Fleck SJ, Pérez M, Lucia A. Intrahospital weight and aerobic training in children with cystic fibrosis: a randomized controlled trial. Medicine And Science In Sports And Exercise 2012; 44(1): 2-11. (AMC)

1347. Santanam L, Hurkmans C, Mutic S, van Vliet-Vroegindeweij C, Brame S, Straube W, Galvin J, Tripuraneni P, Michalski J, Bosch W. Standardizing naming conventions in radiation oncology. Int J Radiat Oncol Biol Phys 2012; 83: 1344-9 (NKI)

1348. Santegoets LA, van Baars R, Terlou A, Heijmans-Antonissen C, Swagemakers SM, van der Spek PJ, Ewing PC, van Beurden M, van der Meijden WI, Helmerhorst TJ, Blok LJ. Different DNA damage and cell cycle checkpoint control in low- and high-risk human papillomavirus infections of the vulva. Int J Cancer 2012; 130: 2874-85 (NKI)

1349. Santo EE, Ebus ME, Koster J, Schulte JH, Lakeman A, van Sluis P, Vermeulen J, Gisselsson D, Øra I, Lindner S, Buckley PG, Stallings RL, Vandesompele J, Eggert A, Caron HN, Versteeg R, Molenaar JJ. Oncogenic activation of FOXR1 by 11q23 intrachromosomal deletion-fusions in neuroblastoma. Oncogene 2012; 31(12): 1571-1581. (AMC)


1350. Sauer R, Creeze H, Hulshof M, Issels R, Ott O. Concerning the final report "Hyperthermia: a systematic review" of the Ludwig Boltzmann Institute for Health Technology Assessment, Vienna, March 2010. Strahlentherapie Und Onkologie 2012; 188(3): 209-213. (AMC)

1351. Schaake EE, Belderbos JS, Buikhuisen WA, Rossi MM, Burgers JA, Sonke JJ. Mediastinal lymph node position variability in non-small cell lung cancer patients treated with radical irradiation. Radiother Oncol 2012; 105: 150-4 (NKI)

1352. Schaake EE, Kappers I, Codrington HE, Valdés Olmos RA, Teertstra HJ, van Pel R, Burgers JA, van Tinteren H, Klomp HM. Tumor response and toxicity of neoadjuvant erlotinib in patients with early-stage non-small-cell lung cancer. J Clin Oncol 2012; 30: 2731-8 (NKI)

1353. Schaapveld M, van den Belt-Dusebout AW, Gietema JA, de Wit R, Horenblas S, Witjes JA, Hoekstra HJ, Kiemeney LA, Louwman WJ, Ouwens GM, Aleman BM, van Leeuwen FE. Risk and prognostic significance of metachronous contralateral testicular germ cell tumours. Br J Cancer 2012; 107: 1637-43 (NKI)

1354. Scharpfenecker M, Floot B, Russell NS, Stewart FA. The TGF-beta co-receptor endoglin regulates macrophage infiltration and cytokine production in the irradiated mouse kidney. Radiother Oncol 2012; 105: 313-20 (NKI)

1355. Schenk GJ, Haasnoot PCJ, Centlivre M, Legrand N, Rip J, de Boer AG, Berkhout B. Efficient CRM197-mediated drug targeting to monocytes. Journal of Controlled Release 2012; 158: 139-147. (VUmc)

1356. Schepers S, Deković M, Feltzer M, de Kleine M, van Baar A. Drawings of very preterm-born children at 5 years of age: a first impression of cognitive and motor development? European Journal Of Pediatrics 2012; 171(1): 43-50. (AMC)

1357. Scherpenisse M, Mollers M, Schepp RM, Boot HJ, de Melker HE, Meijer CJLM, Berbers GAM, van der Klis FRM. Seroprevalence of seven high-risk HPV types in The Netherlands. Vaccine 2012; 30: 6686-6693. (VUmc)

1358. Scherpenisse M, Mollers M, Schepp RM, Boot HJ, Meijer CJLM, Berbers GAM, van der Klis FRM, de Melker HE. Changes in Antibody Seroprevalence of Seven High-Risk HPV Types between Nationwide Surveillance Studies from 1995-96 and 2006-07 in The Netherlands. PloS one 2012; 7: e48807. (VUmc)

1359. Scherrenberg LAM, Stalpers LJA, Grupstra HF, van der Kooi AJ, Koning CCE. Radiotherapie voor speekselvloed bij amyotrofische laterale sclerose en de ziekte van Parkinson*. Nederlands Tijdschrift Voor Geneeskunde 2012; 156(7): A3868-. (AMC)

1360. Schilder CM, Seynave C, Linn SC, Boogerd W, Beex LV, Gundy CM, Nortier JW, van de Velde CJ, van Dam FS, Schagen SB. Self-reported cognitive functioning inostmenopausal breast cancer patients before and during endocrine treatment: findings from the neuropsychological TEAM side-study. Psychooncology 2012; 21: 479-87 (NKI)

1361. Schilder L, Nurmohamed SA, ter Wee PM, Girbes ARJ, Beishuizen A, Paauw NJ, Beelen RHJ, Groeneveld ABJ. Effect of anticoagulation regimens on handling of interleukin-6 and -8 during continuous venovenous hemofiltration in critically ill patients with acute kidney injury. Cytokine 2012; 60: 601-607. (VUmc)

1362. Schiopu A, Nadig SN, Cotoi OS, Hester J, Van Rooijen N, Wood KJ. Inflammatory Ly-6C(hi) monocytes play an important role in the development of severe transplant arteriosclerosis in hyperlipidemic recipients. Atherosclerosis 2012; 223: 291-298. (VUmc)

1363. Schipper MH, van Duinen SG, Taphoorn MJ, Kloet A, Walchenbach R, Wiggenraad RG, Vecht CJ. Cerebral ganglioneuroblastoma of adult onset: Two patients and a review of the literature. Clinical Neurology and Neurosurgery 2012; 114: 529-534. (VUmc)

1364. Schmitt J, Spuls P, Boers M, Thomas K, Chalmers J, Roekevisch E, Schram M, Allsopp R, Aoki V, Apfelbacher C, Bruijnzeel-Koomen C, Bruin-Weller M, Charman C, Cohen A, Dohil M, Flohr C, Furue M, Gieler U, Hooft L, Humphreys R, Ishii HA, Katayama I, Kouwenhoven W, Langan S, Lewis-Jones S, Merhand S, Murota H, Murrell DF, Nankervis H, Ohya Y, Oranje A, Otsuka H, Paul C, Rosenbluth Y, Saeki H, Schuttelaar ML, Stalder JF, Svensson A, Takaoka R, Wahlgren CF, Weidinger S, Wollenberg A, Williams H. Towards global consensus on outcome measures for atopic eczema research: results of the HOME II meeting. Allergy 2012; 67: 1111-1117. (VUmc)

1365. Schmitz AC, Pengel KE, Loo CE, van den Bosch MA, Wesseling J, Gertenbach M, Alderliesten T, Mali WP, Rutgers EJT, Bartelink H, Gilhuijs KG. Pre-treatment imaging and pathology characteristics of invasive breast cancers of limited extent: potential relevance for MRI-guided localized therapy. Radiother Oncol 2012; 104: 11-8 (AMC/NKI)

1366. Schnabel PA, Smit E, de Castro Carpeno J, Lesniewski-Kmak K, Aerts J, Kraaij K, Visseren-Grul C, Dyachkova Y, Taipale K, Girvan A, Moro-Sibilot D. Influence of histology and biomarkers on first-line treatment of advanced non-small cell lung cancer in routine care setting: Baseline results of an observational study (FRAME). Lung Cancer 2012; 78: 263-269. (VUmc)

1367. Schneiders FL, de Bruin RCG, Santegoets SJAM, Bonneville M, Scotet E, Scheper RJ, Verheul HMW, de Gruijl TD, van der Vliet HJ. Activated iNKT cells promote V gamma 9V delta 2-T cell anti-tumor effector functions through the production of TNF-alpha. Clinical Immunology 2012; 142: 194-200. (VUmc)

1368. Schneiders FL, de Bruin RCG, van den Eertwegh AJM, Scheper RJ, Leemans CR, Brakenhoff RH, Langendijk JA, Verheul HMW, de Gruijl TD, Molling JW, van der Vliet HJ. Circulating Invariant Natural Killer T-Cell Numbers Predict Outcome in Head and Neck Squamous Cell Carcinoma: Updated Analysis With 10-Year Follow-Up. J Clin Oncol 2012; 30: 567-570. (VUmc)

1369. Schook RM, Smit EF, Postmus PE, Hartemink KJ, Paul MA. Benefit of a Second Opinion for Lung Cancer No Recurrent Disease, but Infection. Journal of Thoracic Oncology 2012; 7: E6-E7. (VUmc)

1370. Schook RM, Smit EF, Postmus PE, Hartemink KJ, Paul MA. Benefit of a Second Opinion for Lung Cancer: No Recurrent Disease, but Infection (vol 7, pg E6, 2012). Journal of Thoracic Oncology 2012; 7: E33. (VUmc)

1371. Schoot RA, van Ommen CH, Caron HN, Tissing WJE, van de Wetering MD. Accrual in supportive care trials in pediatric oncology, a challenge! Supportive Care In Cancer 2012; 20(12): 3149-3153. (AMC)

1372. Schopman NCT, van Montfort T, Willemsen M, Knoepfel SA, Pollakis G, van Kampen A, Sanders RW, Haasnoot J, Berkhout B. Selective packaging of cellular miRNAs in HIV-1 particles. Virus Research 2012; 169(2): 438-447. (AMC)

1373. Schopman NCT, Willemsen M, Liu YP, Bradley T, van Kampen A, Baas F, Berkhout B, Haasnoot J. Deep sequencing of virus-infected cells reveals HIV-encoded small RNAs. Nucleic Acids Research 2012; 40(1): 414-427. (AMC)

1374. Schramm A, Schowe B, Fielitz K, Heilmann M, Martin M, Marschall T, Köster J, Vandesompele J, Vermeulen J, de Preter K, Koster J, Versteeg R, Noguera R, Speleman F, Rahmann S, Eggert A, Morik K, Schulte JH. Exon-level expression analyses identify MYCN and NTRK1 as major determinants of alternative exon usage and robustly predict primary neuroblastoma outcome. British Journal Of Cancer 2012; 107(8): 1409-1417. (AMC)

1375. Schrevel M, Karim R, ter Haar N, van der Burg S, Trimbos J, Fleuren G, Gorter A, Jordanova E. CXCR7 expression is associated with disease-free and disease-specific survival in cervical cancer patients. Br J Cancer 2012; 106: 1520-1525. (VUmc)


1376. Schrijver A, Reijnen MM, van Oostayen JA, Hoksbergen AW, Lely RJ, van Leersum M, de Vries JP. Initial Results of Catheter-Directed Ultrasound-Accelerated Thrombolysis for Thromboembolic Obstructions of the Aortofemoral Arteries: A Feasibility Study. Cardiovascular and Interventional Radiology 2012; 35: 279-285. (VUmc)

1377. Schuitemaker A, van der Doef TF, Boellaard R, van der Flier WM, Yaqub M, Windhorst AD, Barkhof F, Jonker C, Kloet RW, Lammertsma AA, Scheltens P, van Berckel BNM. Microglial activation in healthy aging. Neurobiology of Aging 2012; 33: 1067-1072. (VUmc)

1378. Schulz S, Chachami G,, et al. Ubiquitinspecific protease-like 1 (USPL1) is a SUMO isopeptidase with essential, non-catalytic functions. EMBO Rep 2012: 13: 930-93 (NKI)

1379. Schumacher U, Nehmann N, Adam E, Mukthar D, Slotki IN, Horny HP, Flens MJ, Schlegelberger B, Steinemann D. MDR-1-overexpression in HT 29 colon cancer cells grown in SCID mice. Acta Histochemica 2012; 114: 594-602. (VUmc)

1380. Schure RM, Hendrikx LH, de Rond LGH, Ozturk K, Sanders EAM, Berbers GAM, Buisman AM. T-Cell Responses before and after the Fifth Consecutive Acellular Pertussis Vaccination in 4-Year-Old Dutch Children. Clinical and Vaccine Immunology 2012; 19: 1879-1886. (VUmc)

1381. Schuurhuis GJ, Zweegman S, Ossenkoppele GJ. The adverse prognosis for acute myeloid leukemia patients with superior autologous stem cell mobilization. Leukemia Research 2012; 36: 1323-1324. (VUmc)

1382. Schwandt T, Schumak B, Gielen GH, Jungerkes F, Schmidbauer P, Klocke K, Staratschek-Jox A, Van Rooijen N, Kraal G, Ludwig-Portugall I, Franken L, Wehner S, Kalff JC, Weber O, Kirschning C, Coch C, Kalinke U, Wenzel J, Kurts C, Zawatzky R, Holzmann B, Layland L, Schultze JL, Burgdorf S, den Haan JMM, Knolle PA, Limmer A. Expression of type I interferon by splenic macrophages suppresses adaptive immunity during sepsis. EMBO Journal 2012; 31: 201-213. (VUmc)

1383. Schwartz G, Bartelink H, Burstein H, Cady B Cataliotti L, Fentiman IS, Holland R, Hughes KS, Masood S, McCormick B, Palazzo JA, Pressman PI, Reis-Filho J, Pusztai L, Rutgers EJ, Seidman AD, Solin LJ, Sparano JA. Adjuvant therapy in stage I carcinoma of the breast: the influence of multigene analyses and molecular phenotyping. Breast J 2012; 18: 303-11 (NKI)

1384. Schwartz GF, Reis-Fihlo J, Pusztai L, Fentiman IS, Holland R, Bartelink H, Rutgers EJT, Solin LJ, Palazzo J; Consensus Committee. Adjuvant therapy in stage I carcinoma of the breast: the influence of multigene analyses and molecula phenotyping. Cancer 2012; 118: 2031-8 (NKI)

1385. Scott NW, Etta JA, Aaronson NK, Bottomley A, Fayers PM, Groenvold M, Koller M, Kuli D, Marais D, Petersen MA, Sprangers MA. An evaluation of the response category translations of the EORTC QLQ-C30 questionnaire. Qual Life Res 2012 (NKI)

1386. Seddon JA, Visser DH, Bartens M, Jordaan AM, Victor TC, van Furth AM, Schoeman JF, Schaaf HS. Impact of Drug Resistance on Clinical Outcome in Children With Tuberculous Meningitis. Pediatric Infectious Disease Journal 2012; 31: 711-716. (VUmc)

1387. Seemann I, Gabriels K, Visser NL, Hoving S, te Poele JA, Pol JF, Gijbels MJ, Janssen BJ, van Leeuwen FW, Daemen MJ, Heeneman S, Stewart FA. Irradiation induces modest changes in murine cardiac function despite progressive structural damage to the myocardium and microvasculature. Radiother Oncol 2012; 103: 143-50 (NKI)

1388. Senan S, Postmus PE. Reflections on the 14th World Conference on Lung Cancer: A European Perspective. Oncologist 2012; 17: 463-465. (VUmc)

1389. Senan S. Stereotactic Body Radiotherapy: Do Central Lung Tumors Still Represent a 'No-Fly Zone'?. Onkologie 2012; 35: 406-407. (VUmc)

1390. Senthi S, Lagerwaard FJ, Haasbeek CJA, Slotman BJ, Senan S. Patterns of disease recurrence after stereotactic ablative radiotherapy for early stage non-small-cell lung cancer: a retrospective analysis. Lancet Oncology 2012; 13: 802-809. (VUmc)

1391. Senthi S, Senan S. Imaging for high-precision thoracic radiotherapy. J Thorac Dis 2012; 4: 106-108. (VUmc) 1392. Senthi S, Verstegen NE, Senan S. Treatment of Peripheral Lung Tumors Arising After a Prior Pneumonectomy. Chest

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1394. Setijowati ED, van Dijk FS, Cobben JM, van Rijn RR, Sistermans EA, Faradz SMH, Kawiyana S, Pals G. A novel homozygous 5 bp deletion in FKBP10 causes clinically Bruck syndrome in an Indonesian patient. European Journal Of Medical Genetics 2012; 55(1): 17-21. (AMC)

1395. Shahand S, Caan MWA, van Kampen AHC, Olabarriaga SD. Integrated support for neuroscience research: from study design to publication. Studies In Health Technology And Informatics 2012; 175: 195-204. (AMC)

1396. Shahand S, Santcroos M, van Kampen AHC, Delgado Olabarriaga S. A Grid-Enabled Gateway for Biomedical Data Analysis. Journal Of Grid Computing 2012; 10(4): 725-742. (AMC)

1397. Shahid MW, Buchner AM, Coron E, Woodward TA, Raimondo M, Dekker E, Fockens P, Wallace MB. Diagnostic accuracy of probe-based confocal laser endomicroscopy in detecting residual colorectal neoplasia after EMR: a prospective study. Gastrointestinal Endoscopy 2012; 75(3): 525-533. (AMC)

1398. Sharples LD, Jackson C, Wheaton E, Griffith G, Annema JT, Dooms C, Tournoy KG, Deschepper E, Hughes V, Magee L, Buxton M, Rintoul RC. Clinical effectiveness and cost-effectiveness of endobronchial and endoscopic ultrasound relative to surgical staging in potentially resectable lung cancer: results from the ASTER randomised controlled trial. Health Technology Assessment 2012; 16(18): 1-75, iii-iv. (AMC)

1399. Shimada S, Mimata A, Sekine M, Mogushi K, Akiyama Y, Fukamachi H, Jonkers J, Tanaka H, Eishi Y, Yuasa Y. Synergistic tumor suppressor activity of E-cadherin and p53 in a conditional mouse model for metastatic diffusetype gastric cancer. Gut 2012; 61: 344-53 (NKI)

1400. Shore N, Mason M, de Reijke TM. New developments in castrate-resistant prostate cancer. BJU International 2012; 109(Suppl. 6): 22-32. (AMC)

1401. Shorning BY, Jardé T, McCarthy A, Ashworth A, de Leng WWJ, Offerhaus GJA, Resta N, Dale T, Clarke AR. Intestinal renin-angiotensin system is stimulated after deletion of Lkb1. GUT 2012; 61(2): 202-213. (AMC)

1402. Siddiq A, Couch FJ, Chen GK, Lindstrom S, Eccles D, Millikan RC, Michailidou K, Stram DO, Beckmann L, Rhie SK, Ambrosone CB, Aittomaki K, Amiano P, Apicella C, Baglietto L, Bandera EV, Beckmann MW, Berg CD, Bernstein L, Blomqvist C, Brauch H, Brinton L, Bui QM, Buring JE, Buys SS, Campa D, Carpenter JE, Chasman DI, Chang-Claude J, Chen C, Clavel-Chapelon F, Cox A, Cross SS, Czene K, Deming SL, Diasio RB, Diver WR, Dunning AM, Durcan L, Ekici AB, Fasching PA, Feigelson HS, Fejerman L, Figueroa JD, Fletcher O, Flesch-Janys D, Gaudet MM, Gerty SM,


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1403. Siemerink MJ, Klaassen I, Vogels IMC, Griffioen AW, van Noorden CJF, Schlingemann RO. CD34 marks angiogenic tip cells in human vascular endothelial cell cultures. Angiogenesis 2012; 15(1): 151-163. (AMC/VUmc)

1404. Sierink JC, Saltzherr TP, Reitsma JB, van Delden OM, Luitse JSK, Goslings JC. Systematic review and meta-analysis of immediate total-body computed tomography compared with selective radiological imaging of injured patients. British Journal Of Surgery 2012; 99(Suppl. 1): 52-58. (AMC)

1405. Sieswerda E, Postma A, van Dalen EC, van der Pal HJH, Tissing WJE, Rammeloo LAJ, Kok WEM, van Leeuwen FE, Caron HN, Kremer LCM. The Dutch Childhood Oncology Group guideline for follow-up of asymptomatic cardiac dysfunction in childhood cancer survivors. Annals Of Oncology 2012; 23(8): 2191-2198. (AMC/NKI)

1406. Sieswerda-Hoogendoorn T, Boos S, Spivack B, Bilo RAC, van Rijn RR. Abusive head trauma Part II: radiological aspects. European journal of pediatrics 2012; 171(4): 617-623. (AMC)

1407. Sieswerda-Hoogendoorn T, Boos S, Spivack B, Bilo RAC, van Rijn RR. Educational paper: Abusive Head Trauma part I. Clinical aspects. European Journal Of Pediatrics 2012; 171(3): 415-423. (AMC)

1408. Siggberg L, Alla-Melo S, Linnankivi T, Avela K, Scheinin AI, Kristiansson K, Lahermo P, Hietala M, Metsõhonkala L, Kuusinen E, Laaksonen M, Saarela J, Knuutila S. High-resolution SNP array analysis of patients with developmental disorder and normal array CGH results. BMC Medical Genetics 2012; 13: . (VUmc)

1409. Sigmond J, Leon LG, Kamphuis JAE, Bergman AM, Peters GJ. Effect of staurosporine and ucn-01 on gemcitabine cytotoxicity in relation to cell cycle effects and p53 status. Cancer Therapeutics Research. 2012 (NKI)

1410. Sikkema AH, den Dunnen WFA, Hulleman E, van Vuurden DG, Garcia-Manero G, Yang H, Scherpen FJG, Kampen KR, Hoving EW, Kamps WA, Diks SH, Peppelenbosch MP, De Bont ELSJ. EphB2 activity plays a pivotal role in pediatric medulloblastoma cell adhesion and invasion. Neuro-Oncology 2012; 14: 1125-1135. (VUmc)

1411. Sillars-Hardebol AH, Carvalho B, Belien JA, de Wit M, is-van Diemen PM, Tijssen M, van de Wiel MA, Ponten F, Fijneman RJA, Meijer GA. BCL2L1 has a functional role in colorectal cancer and its protein expression is associated with chromosome 20q gain. Journal of Pathology 2012; 226: 442-450. (VUmc)

1412. Sillars-Hardebol AH, Carvalho B, Belien JAM, de Wit M, Delis-van Diemen PM, Tijssen M, van de Wiel MA, Ponten F, Meijer GA, Fijneman RJA. CSE1L, DIDO1 and RBM39 in colorectal adenoma to carcinoma progression. Cell Oncol 2012; 35: 293-300. (VUmc)

1413. Sillars-Hardebol AH, Carvalho B, Tijssen M, Belien JAM, de Wit M, is-van Diemen PM, Ponten F, van de Wiel MA, Fijneman RJA, Meijer GA. TPX2 and AURKA promote 20q amplicon-driven colorectal adenoma to carcinoma progression. Gut 2012; 61: 1568-1575. (VUmc)

1414. Sillars-Hardebol AH, Carvalho B, van Engeland M, Fijneman RJA, Meijer GA. The adenoma hunt in colorectal cancer screening: defining the target. Journal of Pathology 2012; 226: 1-6. (VUmc)

1415. Silva SL, Vaz AR, Diogenes MJ, Van Rooijen N, Sebastiao AM, Fernandes A, Silva RFM, Brites D. Neuritic growth impairment and cell death by unconjugated bilirubin is mediated by NO and glutamate, modulated by microglia, and prevented by glycoursodeoxycholic acid and interleukin-10. Neuropharmacology 2012; 62: 2398-2408. (VUmc)

1416. Simeone R, Bobard A, Lippmann J, Bitter W, Majlessi L, Brosch R, Enninga J. Phagosomal Rupture by Mycobacterium tuberculosis Results in Toxicity and Host Cell Death. Plos Pathogens 2012; 8: . (VUmc)

1417. Sinha IP, Altman DG, Beresford MW, Boers M, Clarke M, Craig J, Alberighi OD, Fernandes RM, Hartling L, Johnston BC, Lux A, Plint A, Tugwell P, Turner M, van der Lee JH, Offringa M, Williamson PR, Smyth RL. Standard 5: Selection, Measurement, and Reporting of Outcomes in Clinical Trials in Children. Pediatrics 2012; 129: S146-S152. (VUmc)

1418. Sint Nicolaas J, de Jonge V, Cahen DL, Ouwendijk RJ, Tang TJ, van Tilburg AJ, van Leerdam ME, Kuipers EJ; SCoPE Consortium. Awareness of surveillance recommendations among patients with colorectal adenomas. Clin Gastroenterol Hepatol 2012; 10: 405-11 (NKI)

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1421. Sitarz R, Maciejewski R, Polkowski WP, Offerhaus GJA. Gastroenterostoma after Billroth antrectomy as a premalignant condition. World Journal Of Gastroenterology 2012; 18(25): 3201-3206. (AMC)

1422. Sivachandran N, Dawson CW, Young LS, Liu FF, Middeldorp J, Frappier L. Contributions of the Epstein-Barr Virus EBNA1 Protein to Gastric Carcinoma. Journal of Virology 2012; 86: 60-68. (VUmc)

1423. Sizoo EM, Pasman HRW, Buttolo J, Heimans JJ, Klein M, Deliens L, Reijneveld JC, Taphoorn MJB. Decision-making in the end-of-life phase of high-grade glioma patients. European Journal of Cancer 2012; 48: 226-232. (VUmc)

1424. Skolarikos A, Laguna MP, de La Rosette JJMCH. Conservative and radiological management of simple renal cysts: a comprehensive review. BJU International 2012; 110(2): 170-178. (AMC)

1425. Slobbe P, Poot AJ, Windhorst AD, van Dongen GAMS. PET imaging with small-molecule tyrosine kinase inhibitors: TKI-PET. Drug Discovery Today 2012; 17: 1175-1187. (VUmc)

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1431. Smit E, Socinski M, Mullaney B, Myrand S, Scagliotti G, V, Lorigan P, Reck M, Ciuleanu T, von Pawel J, Karaseva N, Szczesna A, Ohannesian D, Powell E, Hozak R, Hong S, Guba S, Thatcher N. Biomarker analysis in a phase III study of pemetrexed-carboplatin versus etoposide-carboplatin in chemonaive patients with extensive-stage small-cell lung cancer. Annals of Oncology 2012; 23: 1723-1729. (VUmc)

1432. Smit JJ, Monteferrario D, Noordermeer SM, van Dijk WJ, van der Reijden BA, Sixma TK. The E3 ligase HOIP specifies linear ubiquitin chain assembly through its RING-IBR-RING domain and the unique LDD extension. EMBO J 2012; 31: 3833-44 (NKI)

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1435. Smits M, Wurdinger T, van het Hof B, Drexhage JAR, Geerts D, Wesseling P, Noske DP, Vandertop WP, de Vries HE, Reijerkerk A. Myc-associated zinc finger protein (MAZ) is regulated by miR-125b and mediates VEGF-induced angiogenesis in glioblastoma. Faseb Journal 2012; 26: 2639-2647. (VUmc)

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1451. Sparidans RW, Tang SC, Nguyen LN, Schinkel AH, Schellens JH, Beijnen JH. Liquid chromatography-tandem mass spectrometric assay for the ALK inhibitor crizotinib in mouse plasma. J Chromatogr B Analyt Technol Biomed Life Sci 2012; 905: 150-4 (NKI)

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1470. Stieger B, Heger M, de Graaf W, Paumgartner G, van Gulik T. The emerging role of transport systems in liver function tests. European Journal Of Pharmacology 2012; 675(1-3): 1-5. (AMC)

1471. Stiekema J, Boot H, Aleman BM, Wessels LFA, van Sandick JW. Prognostication and prediction using gene expression profiling in oesophageal cancer. Eur J Surg Oncol. 2013; 39: 17-23 (NKI)

1472. Stippel G, van Rooijen DC, Crezee J, Bel A. Automatic delineation of body contours on cone-beam CT images using a delineation booster. Physics In Medicine And Biology 2012; 57(13): N225-N236. (AMC)

1473. Stobbe MD, Houten SM, van Kampen AHC, Wanders RJA, Moerland PD. Improving the description of metabolic networks: the TCA cycle as example. Faseb Journal 2012; 26(9): 3625-3636. (AMC)

1474. Stoker SD, Greijer AE, Wildeman MA, Novalic Z, de Boer JP, Huitema ADR, Fles R, Karakullukcu B, Middeldorp JM, Tan IB. Nieuwe diagnostische middelen en behandeltechnieken voor het nasofarynxcarcinoom. Ned Tijdschr Oncol 2012; 9: 262-8 (NKI)

1475. Stokkel MP, de Wit-van der Veen LJ, Boekhout A. I-123-MIBG myocardial imaging in trastuzumab-based cardiotoxicity: the first experience. Nucl Med Commun 2013; 34: 19-24 (NKI)

1476. Stokkel MP, van der Hiel B, Valdés Olmos R, Hoefnagel K. Fluorodeoxyglucose PET/CT in subcutaneous sarcoidosis mimicking cutaneous lymphoma. Eur J Nucl Med Mol Imaging 2012; 39: 919-920 (NKI)

1477. Stoop EJM, Bitter W, van der Sar AM. Tubercle bacilli rely on a type VII army for pathogenicity. Trends in Immunology 2012; 20: 477-484. (VUmc)

1478. Stoop EM, de Haan MC, de Wijkerslooth TR, Bossuyt PM, van Ballegooijen M, Yung Nio C, van de Vijver MJ, Biermann K, Thomeer M, van Leerdam ME, Fockens P, Stoker J, Kuipers EJ, Dekker E.: Participation and yield of colonoscopy versus non-cathartic CT colonography in population-based screening for colorectal cancer: a randomised controlled trial. Lancet Oncology 2012; 13(1): 55-64. (AMC/NKI)

1479. Stoop EM, de Wijkerslooth TR, Bossuyt PM, Stoker J, Fockens P, Kuipers EJ, Dekker E, van Leerdam ME. Face-to-face vs telephone pre-colonoscopy consultation in colorectal cancer screening; a randomised trial. British Journal Of Cancer 2012; 107(7): 1051-1058. (AMC/NKI)

1480. Stoot JHMB, Wong-Lun-Hing EM, Limantoro I, Visschers R, Busch OR, van Hillegersberg R, de Jong KM, Rijken AM, Kazemier G, Olde Damink SWM, Lodewick TM, Bemelmans MHA, van Dam RM, Dejong CHC. Laparoscopic liver resection in the Netherlands: how far are we? Digestive Surgery 2012; 29(1): 70-78. (AMC)

1481. Stormer M, Arroyo A, Brachert J, Carrero H, Devine D, Epstein JS, Gabriel C, Gelber C, Goodrich R, Hanschmann KM, Heath DG, Jacobs MR, Keil S, de Korte D, Lambrecht B, Lee CK, Marcelis J, Marschner S, McDonald C, McGuane S, Mckee M, Muller TH, Muthivhi T, Pettersson A, Radziwon P, Ramirez-Arcos S, Reesink HW, Rojo J, Rood I, Schmidt M, Schneider CK, Seifried E, Sicker U, Wendel S, Wood EM, Yomtovian RA, Montag T. Establishment of the first


International Repository for Transfusion-Relevant Bacteria Reference Strains: ISBT Working Party Transfusion-Transmitted Infectious Diseases (WP-TTID), Subgroup on Bacteria. Vox Sanguinis 2012; 102: 22-31. (VUmc)

1482. Strasberg SM, Gouma DJ. 'Extreme' vasculobiliary injuries: association with fundus-down cholecystectomy in severely inflamed gallbladders. HPB 2012; 14(1): 1-8. (AMC)

1483. Stroobant V, Demotte N, Luiten RM, Leonhardt RM, Cresswell P, Bonehill A, Michaux A, Ma W, Mulder A, van den Eynde BJ, van der Bruggen P, Vigneron N. Inefficient exogenous loading of a tapasin-dependent peptide onto HLA-B*44:02 can be improved by acid treatment or fixation of target cells. European Journal Of Immunology 2012; 42(6): 1417-1428. (AMC)

1484. Struikmans H, Aarts MJ, Jobsen JJ, Koning CCE, Poortmans PMP, Louwman MWJ, Coebergh JWJ. Trends in toepassing van primaire radiotherapie voor kanker in Nederland: Bij patiënten met tumoren van borst, prostaat, endeldarm en long. Nederlands Tijdschrift Voor Geneeskunde 2012; 156(12): A4426-. (AMC)

1485. Stukstette MJPM, Hoogeboom TJ, de Ruiter R, Koelmans P, Veerman E, den Broeder AA, Cats H, Bijlsma JW, Dekker J, van den Ende CHM. A multidisciplinary and multidimensional intervention for patients with hand osteoarthritis. Clinical Rehabilitation 2012; 26: 99-110. (VUmc)

1486. Sturm D, Witt H, Hovestadt V, Khuong-Quang DA, Jones DTW, Konermann C, Pfaff E, Tönjes M, Sill M, Bender S, Kool M, Zapatka M, Becker N, Zucknick M, Hielscher T, Liu XY, Fontebasso AM, Ryzhova M, Albrecht S, Jacob K, Wolter M, Ebinger M, Schuhmann MU, van Meter T, Frühwald MC, Hauch H, Pekrun A, Radlwimmer B, Niehues T, von Komorowski G, Dürken M, Kulozik AE, Madden J, Donson A, Foreman NK, Drissi R, Fouladi M, Scheurlen W, von Deimling A, Monoranu C, Roggendorf W, Herold-Mende C, Unterberg A, Kramm CM, Felsberg J, Hartmann C, Wiestler B, Wick W, Milde T, Witt O, Lindroth AM, Schwartzentruber J, Faury D, Fleming A, Zakrzewska M, Liberski PP, Zakrzewski K, Hauser P, Garami M, Klekner A, Bognar L, Morrissy S, Cavalli F, Taylor MD, van Sluis P, Koster J, Versteeg R, Volckmann R, Mikkelsen T, Aldape K, Reifenberger G, Collins VP, Majewski J, Korshunov A, Lichter P, Plass C, Jabado N, Pfister SM. Hotspot mutations in H3F3A and IDH1 define distinct epigenetic and biological subgroups of glioblastoma. Cancer Cell 2012; 22(4): 425-437. (AMC)

1487. Stutterheim J, Ait Ichou F, den Ouden E, Versteeg R, Caron HN, Tytgat GAM, van der Schoot CE. Methylated RASSF1a is the first specific DNA marker for minimal residual disease testing in neuroblastoma. Clinical Cancer Research 2012; 18(3): 808-814. (AMC)

1488. Stutterheim J, Zappeij-Kannegieter L, Ora I, van Sluis PG, Bras J, den Ouden E, Versteeg R, Caron HN, van der Schoot CE, Tytgat GAM. Stability of PCR targets for monitoring minimal residual disease in neuroblastoma. Journal Of Molecular Diagnostics 2012; 14(2): 168-175. (AMC)

1489. Su Z, Gay LJ, Strange A, Palles C, Band G, Whiteman DC, Lescai F, Langford C, Nanji M, Edkins S, van der Winkel A, Levine D, Sasieni P, Bellenguez C, Howarth K, Freeman C, Trudgill N, Tucker AT, Pirinen M, Peppelenbosch MP, van der Laan LJW, Kuipers EJ, Drenth JPH, Peters WH, Reynolds JV, Kelleher DP, McManus R, Grabsch H, Prenen H, Bisschops R, Krishnadath K, Siersema PD, van Baal JWPM, Middleton M, Petty R, Gillies R, Burch N, Bhandari P, Paterson S, Edwards C, Penman I, Vaidya Kr, Ang Y, Murray I, Patel P, Ye W, Mullins P, Wu AH, Bird NC, Dallal H, Shaheen NJ, Murray LJ, Koss K, Bernstein L, Romero Y, Hardie LJ, Zhang R, Winter H, Corley DA, Panter S, Risch HA, Reid BJ, Sargeant I, Gammon MD, Smart H, Dhar A, McMurtry H, Ali H, Liu G, Casson AG, Chow WH, Rutter M, Tawil A, Morris D, Nwokolo C, Isaacs P, Rodgers C, Ragunath K, MacDonald C, Haigh C, Monk D, Davies G, Wajed S, Johnston D, Gibbons M, Cullen S, Church N, Langley R, Griffin M, Alderson D, Deloukas P, Hunt SE, Gray E, Dronov S, Potter SC, Tashakkori-Ghanbaria A, Anderson M, Brooks C, Blackwell JM, Bramon E, Brown MA, Casas JP, Corvin A, Duncanson A, Markus HS, Mathew CG, Palmer CNA, Plomin R, Rautanen A, Sawcer SJ, Trembath RC, Viswanathan AC, Wood N, Trynka G, Wijmenga C, Cazier JB, Atherfold P, Nicholson AM, Gellatly NL, Glancy D, Cooper SC, Cunningham D, Lind T, Hapeshi J, Ferry D, Rathbone B, Brown J, Love S, Attwood S, Macgregor S, Watson P, Sanders S, Ek W, Harrison RF, Moayyedi P, de Caestecker J, Barr H, Stupka E, Vaughan TL, Peltonen L, Spencer CCA, Tomlinson I, Donnelly P, Jankowski JAZ. Common variants at the MHC locus and at chromosome 16q24.1 predispose to Barrett's esophagus. Nature Genetics 2012; 44(10): 1131-1136. (AMC)

1490. Suijkerbuijk SJ, van Dam TJ, Karagoz GE, von Castelmur E, Hubner NC, Duarte AM, Vleugel M, Perrakis A, Rudiger SG, Snel B, Kops GJ. The vertebrate mitotic checkpoint protein BUBR1 is an unusual pseudokinase. Developmental cell 2012; 22: 1321-9 (NKI)

1491. Sun T, Simon I, Moreno V, Roepman P, Tabernero J, Snel M, Van’t Veer L, Salazar R, Bernards R, Capella G. A combined oncogenic pathway signature of BRAF, KRAS and PI3KCA mutation improves colorectal cancer classification and cetuximab treatment prediction. Gut. 2012 (NKI)

1492. Sundara YT, Jordanova ES, Hernowo BS, Gandamihardja S, Fleuren GJ. Decidual infiltration of FoxP3(+) regulatory T cells, CD3(+) T cells, CD56(+) decidual natural killer cells and Ki-67 trophoblast cells in hydatidiform mole compared to normal and ectopic pregnancies. Molecular Medicine Reports 2012; 5: 275-281. (VUmc)

1493. Supriyadi E, Veerman AJP, Sutaryo, Purwanto I, van der Ven PM, Cloos J. Myeloid Antigen Expression in Childhood Acute Lymphoblastic Leukemia and Its Relevance for Clinical Outcome in Indonesian ALL-2006 Protocol. J Oncol 2012; 2012: 135186. (VUmc)

1494. Suwannalai P, van de Stadt L, Radner H, Steiner G, El-Gabalawy H, Jol-van der Zijde C, van Tol M, van Schaardenburg D, Huizinga T, Toes R, Trouw L. Avidity maturation of anti-citrullinated protein antibodies in rheumatoid arthritis. Arthritis and Rheumatism 2012; 64: 1323-1328. (VUmc)

1495. Svicher V, Cento V, Bernassola M, Neumann-Fraune M, van Hemert F, Chen M, Salpini R, Liu C, Longo R, Visca M, Romano S, Micheli V, Bertoli A, Gori C, Ceccherini-Silberstein F, Sarrecchia C, Andreoni M, Angelico M, Ursitti A, Spanò A, Zhang JM, Verheyen J, Cappiello G, Perno CF. Novel HBsAg markers tightly correlate with occult HBV infection and strongly affect HBsAg detection. Antiviral Research 2012; 93(1): 86-93. (AMC)

1496. Svilar D, Vens C, Sobol RW. Quantitative, real-time analysis of base excision repair activity in cell lysates utilizing lesion-specific molecular beacons. J Vis Exp 2012; 66: e4168 (NKI)

1497. Swanefeld FH, van Dorp WT, Visser O, de Klerk G. Waldenstr÷m macroglobulinaemia presenting with nephrotic syndrome.. Netherlands Journal of Medicine 2012; 70: 411-413. (VUmc)

1498. Swinnen I, Goossens A, Rustemeyer T. Allergic contact dermatitis caused by C30-38 olefin/isopropyl maleate/MA copolymer in cosmetics. Contact Dermatitis 2012; 67: 318-320. (VUmc)

1499. Sylvester R, Collette L, Bex A, Clarke N, Sternberg CL, Tombal B. The EORTC Genito-Urinary Cancers Group: 35 years of achievements and future strategy. EJC Suppl 2012; 10: 58-65 (NKI)


1500. Syvanen S, Labots M, Tagawa Y, Eriksson J, Windhorst AD, Lammertsma AA, de Lange EC, Voskuyl RA. Altered GABA(A) Receptor Density and Unaltered Blood Brain Barrier Transport in a Kainate Model of Epilepsy: An In Vivo Study Using C-11-Flumazenil and PET. Journal of Nuclear Medicine 2012; 53: 1974-1983. (VUmc)

1501. Szegedi K, Kremer AE, Kezic S, Teunissen MBM, Bos JD, Luiten RM, Res PC, Middelkamp-Hup MA. Increased frequencies of IL-31-producing T cells are found in chronic atopic dermatitis skin. Experimental Dermatology 2012; 21(6): 431-436. (AMC)

1502. Tack GJ, van Asseldonk DP, van Wanrooij RLJ, van Bodegraven AA, Mulder CJ. Tioguanine in the treatment of refractory coeliac disease - a single centre experience. Alimentary Pharmacology & Therapeutics 2012; 36: 274-281. (VUmc)

1503. Tack GJ, van Wanrooij RLJ, Langerak AW, Tjon JML, von Blomberg BME, Heideman DAM, van Bergen J, Koning F, Bouma G, Mulder CJJ, Schreurs MWJ. Origin and immunophenotype of aberrant IEL in RCDII patients. Molecular Immunology 2012; 50: 262-270. (VUmc)

1504. Tack GJ, van Wanrooij RLJ, von Blomberg BME, Amiano P, Amini H, Coupe VMH, Bonnet P, Mulder CJJ, Schreurs MWJ. Serum parameters in the spectrum of coeliac disease: beyond standard antibody testing - a cohort study. BMC Gastroenterology 2012; 12: 159. (VUmc)

1505. Tacke CE, Haverman L , Berk BM, van Rossum MA, Kuipers IM, Grootenhuis MA, Kuijpers TW. Quality of life and behavioral functioning in Dutch children with a history of Kawasaki disease. Journal Of Pediatrics 2012; 161(2): 314-9.e1. (AMC)

1506. Taghipour K, Kirtschig G, Palace J, Groves RW, Venning V, Wojnarowska F. The association of multiple sclerosis with bullous pemphigoid: Is there a shared antigen response?. Journal of the American Academy of Dermatology 2012; 67: 160-161. (VUmc)

1507. Takes RP, Rinaldo A, Silver CE, Haigentz M, Woolgar JA, Triantafyllou A, Mondin V, Paccagnella D, de Bree R, Shaha AR, Hartl DM, Ferlito A. Distant metastases from head and neck squamous cell carcinoma. Part I. Basic aspects. Oral Oncology 2012; 48: 775-779. (VUmc)

1508. Talacchi A, Taphoorn M, Miceli G. Reconsidering outcomes that matter to patients INTRODUCTION. Journal of Neuro-Oncology 2012; 108: 219-220. (VUmc)

1509. Tamminga SJ, de Boer AGEM, Bos MMEM, Fons G, Kitzen JJEM, Plaisier PW, Verbeek JHAM, Frings-Dresen MHW. A hospital-based work support intervention to enhance the return to work of cancer patients: a process evaluation. Journal Of Occupational Rehabilitation 2012; 22(4): 565-578. (AMC)

1510. Tamminga SJ, de Boer AGEM, Verbeek JHAM, Frings-Dresen MHW. Breast cancer survivors' views of factors that influence the return-to-work process--a qualitative study. Scandinavian Journal Of Work Environment & Health 2012; 38(2): 144-154.

1511. Tang SC, Lagas JS, Lankheet NA, Poller B, Hillebrand MJ, Rosing H, Beijnen JH, Schinkel AH. Brain accumulation of sunitinib is restricted by P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) and can be enhanced by oral elacridar and sunitinib coadministration. Int J Cancer 2012; 130: 223-33 (NKI)

1512. Tang SC, Lankheet NA, Poller B, Wagenaar E, Beijnen JH, Schinkel AH. P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) restrict brain accumulation of the active sunitinib metabolite N-desethyl sunitinib. J Pharmacol Exp Ther 2012; 341: 164-73 (NKI)

1513. Tanis E, van de Velde CJH, Bartelink H, van de Vijver MJ, Putter H, van der Hage JA. Locoregional recurrence after breast-conserving therapy remains an independent prognostic factor even after an event free interval of 10 years in early stage breast cancer. European Journal Of Cancer 2012; 48(12): 1751-1756. (AMC/NKI)

1514. Taphoorn MJ. Patient-oriented outcome measures in brain tumor patients: catching up after a slow start. Expert Review of Pharmacoeconomics & Outcomes Research 2012; 12: 1-3. (VUmc)

1515. Taremi M, Hope A, Dahele M, Pearson S, Fung S, Purdie T, Brade A, Cho J, Sun A, Bissonnette JP, Bezjak A. Stereotactic Body Radiotherapy for Medically Inoperable Lung Cancer: Prospective, Single-Center Study of 108 Consecutive Patients. International Journal of Radiation Oncology Biology Physics 2012; 82: 967-973. (VUmc)

1516. Taremi M, Hope A, Lindsay P, Dahele M, Fung S, Purdie TG, Jaffray D, Dawson L, Bezjak A. Predictors of Radiotherapy Induced Bone Injury (RIBI) after stereotactic lung radiotherapy. Radiation Oncology 2012; 17: 159. (VUmc)

1517. Tarnanen S, Neva MH, Dekker J, Hakkinen K, Vihtonen K, Pekkanen L, Hakkinen A. Randomized controlled trial of postoperative exercise rehabilitation program after lumbar spine fusion: study protocol. BMC Musculoskeletal Disorders 2012; 13: . (VUmc)

1518. Tarp S, Bartels EM, Bliddal H, Furst DE, Boers M, nneskiold-Samsoe B, Rasmussen M, Christensen R. Effect of Nonsteroidal Antiinflammatory Drugs on the C-Reactive Protein Level in Rheumatoid Arthritis A Meta-Analysis of Randomized Controlled Trials. Arthritis and Rheumatism 2012; 64: 3511-3521. (VUmc)

1519. te Beek ET, de Boer P, Moerland M, Schmidt ME, Hoetjes NJ, Windhorst AD, van Berckel BNM, Cohen AF, van Gerven JMA, Lammertsma AA. In vivo quantification of striatal dopamine D-2 receptor occupancy by JNJ-37822681 using [C-11]raclopride and positron emission tomography. Journal of Psychopharmacology 2012; 26: 1128-1135. (VUmc)

1520. te Raa GD, Tonino SH, Remmerswaal EBM, van Houte AJ, Koene HR, van Oers MH, Kater AP. Chronic lymphocytic leukemia specific T-cell subset alterations are clone-size dependent and not present in monoclonal B lymphocytosis. Leukemia & Lymphoma 2012; 53(11): 2321-2325. (AMC)

1521. te Raa GD, van Oers MH, Kater AP. Monoclonal B-cell lymphocytosis: recommendations from the Dutch Working Group on CLL for daily practice. Netherlands Journal Of Medicine 2012; 70(5): 236-241. (AMC)

1522. te Raa GD, van Oers MH, Kater AP. Monoklonale B-cellymfocytose: incidentie, risicostratificatie en aanbevelingen voor de dagelijkse praktijk. Nederlands Tijdschrift Voor Hematologie 2012; 9: 138-. (AMC)

1523. Tee JM, Sartori da Silva MA, Rygiel AM, Muncan V, Bink R, van den Brink GR, van Tijn P, Zivkovic D, Kodach LL, Guardavaccaro D, Diks SH, Peppelenbosch MP. asb11 is a regulator of embryonic and adult regenerative myogenesis. Stem Cells And Development 2012; 21(17): 3091-3103. (AMC)

1524. Teeuw AH, Derkx BHF, Koster WA, van Rijn RR. Educational paper: Detection of child abuse and neglect at the emergency room. European Journal Of Pediatrics 2012; 171(6): 877-885. (AMC)

1525. Tefekli A, Tepeler A, Akman T, Akçay M, Baykal M, Karadağ MA, Muslumanoglu AY, de la Rosette J. The comparison of laparoscopic pyelolithotomy and percutaneous nephrolithotomy in the treatment of solitary large renal pelvic stones. Urological Research 2012; 40(5): 549-555. (AMC)

1526. Tefsen B, Lagendijk EL, Park J, Akeroyd M, Schachtschabel D, Winkler R, van Die I, Ram AFJ. Fungal alpha-arabinofuranosidases of glycosyl hydrolase families 51 and 54 show a dual arabinofuranosyl- and galactofuranosyl-hydrolyzing activity. Biological Chemistry 2012; 393: 767-775. (VUmc)


1527. Tefsen B, Ram AFJ, van Die I, Routier FH. Galactofuranose in eukaryotes: aspects of biosynthesis and functional impact. Glycobiology 2012; 22: 456-469. (VUmc)

1528. Tekirdag KA, Korkmaz G, Ozturk DG, Agami R, Gozuacik D. MIR181A regulates starvation- and rapamycininduced autophagy through targeting of ATG5. Autophagy. 2013; 9: 374-85 (NKI)

1529. Temviriyanukul P, Van Hees-Stuivenberg S, Delbos F, Jacobs H, De Wind N, and Jansen JG. Temporally distinct translesion synthesis pathways for ultraviolet light-induced photoproducts in the mammalian genome. DNA Repair 2012; 11: 550-8 (NKI)

1530. ten Cate-Hoek AJ, van der Velde EF, Toll DB, van Weert HCPM, Moons KGM, Büller HR, Hoes AW, Joore MA, Oudega R, Prins MH, Stoffers HEJH. Common alternative diagnoses in general practice when deep venous thrombosis is excluded. Netherlands Journal Of Medicine 2012; 70(3): 130-135. (AMC)

1531. ter Riet G, Korevaar DA, Leenaars M, Sterk PJ, van Noorden CJF, Bouter LM, Lutter R, Oude Elferink RP, Hooft L. Publication bias in laboratory animal research: a survey on magnitude, drivers, consequences and potential solutions. Plos One 2012; 7(9): e43404-. (AMC)

1532. ter Wee MM, Lems WF, Usan H, Gulpen A, Boonen A. The effect of biological agents on work participation in rheumatoid arthritis patients: a systematic review. Annals of the Rheumatic Diseases 2012; 71: 161-171. (VUmc)

1533. Terhaar sive Droste JS, van Turenhout ST, Oort FA, van der Hulst RWM, Steeman VA, Coblijn U, van der Eem L, Duijkers R, Bouman AA, Meijer GA, Depla ACTM, Scholten P, Loffeld RJLF, Coupe VMH, Mulder CJJ. Faecal immunochemical test accuracy in patients referred for surveillance colonoscopy: a multi-centre cohort study. BMC Gastroenterology 2012; 12: 94. (VUmc)

1534. Terhaar sive Droste JS, Van Weyenberg SJB. Ischemic colitis with diverticular sparing. Gastrointestinal Endoscopy 2012; 75: 424. (VUmc)

1535. Terlou A, Santegoets LA, van der Meijden WI, Heijmans-Antonissen C, Swagemakers SM, van der Spek PJ, Ewing PC, van Beurden M, Helmerhorst TJ, Blok LJ. An autoimmune phenotype in vulvar lichen sclerosus and lichen planus: a Th1 response and high levels of microRNA-155. J invest Dermatol 2012; 132: 658-66 (NKI)

1536. Teruel M, Simeon CP, Broen J, Vonk MC, Carreira P, Camps MT, Garcia-Portales R, gado-Frias E, Gallego M, Espinosa G, Beretta L, Airo P, Lunardi C, Riemekasten G, Witte T, Krieg T, Kreuter A, Distler JHW, Hunzelmann N, Koeleman BP, Voskuyl AE, Schuerwegh AJ, Gonzalez-Gay MA, Radstake TRDJ, Martin J. Analysis of the association between CD40 and CD40 ligand polymorphisms and systemic sclerosis. Arthritis Research & Therapy 2012; 14: R154. (VUmc)

1537. Terwijn M, Kelder A, Snel AN, Rutten AP, Scholten WJ, Oussoren YJM, van de Loosdrecht AA, Zweegman S, Ossenkoppele GJ, Schuurhuis GJ. Minimal residual disease detection defined as the malignant fraction of the total primitive stem cell compartment offers additional prognostic information in acute myeloid leukaemia. International Journal of Laboratory Hematology 2012; 34: 432-441. (VUmc)

1538. Teunis P, van Eijkeren J, Ang C, van Duynhoven Y, Simonsen J, Strid M, van Pelt W. Biomarker dynamics: estimating infection rates from serological data. Statistics in Medicine 2012; 31: 2240-2248. (VUmc)

1539. Teunissen CE, Sombekke M, van Winsen L, Killestein J, Barkhof F, Polman CH, Dijkstra CD, Blankenstein MA, Pratico D. Increased plasma 8,12-iso-iPF2alpha-VI levels in relapsing multiple sclerosis patients are not predictive of disease progression. Multiple Sclerosis Journal 2012; 18: 1092-1098. (VUmc)

1540. Tewarie P, Teunissen CE, Dijkstra CD, Heijnen DAM, Vogt M, Balk L, Vrenken H, Polman CH, Killestein J. Cerebrospinal fluid anti-whole myelin antibodies are not correlated to magnetic resonance imaging activity in multiple sclerosis. Journal of Neuroimmunology 2012; 251: 103-106. (VUmc)

1541. Thas O, Clement L, Rayner JCW, Carvalho B, van Criekinge W. An Omnibus Consistent Adaptive Percentile Modified Wilcoxon Rank Sum Test with Applications in Gene Expression Studies. Biometrics 2012; 68: 446-454. (VUmc)

1542. Theocharides APA, Jin LQ, Cheng PY, Prasolava TK, Malko AV, Ho JM, Poeppl AG, Van Rooijen N, Minden MD, Danska JS, Dick J, Wang JCY. Disruption of SIRP alpha signaling in macrophages eliminates human acute myeloid leukemia stem cells in xenografts. Journal of Experimental Medicine 2012; 209: 1883-1899. (VUmc)

1543. Theunissen EAR, Timmermans AJ, Zuur CL, Hamming-Vrieze O, de Boer JP, Hilgers FJM, van den Brekel MWM. Total laryngectomy for a dysfunctional larynx after (chemo)radiotherapy. Arch Otolaryngol Head Neck Surg 2012; 138: 548-55 (NKI)

1544. Thijs KM, de Boer AGEM, Vreugdenhil G, van de Wouw AJ, Houterman S, Schep G. Rehabilitation Using High-Intensity Physical Training and Long-Term Return-to-Work in Cancer Survivors. Journal Of Occupational Rehabilitation 2012; 22(2): 220-229. (AMC)

1545. Thorwarth D, Beyer T, Boellaard R, de Ruysscher D, Grgic A, Lee JA, Pietrzyk U, Sattler B, Schaefer A, van Elmpt W, Vogel W, Oyen WJ, Nestle U. Integration of FDG-PET/CT into external beam radiation therapy planning: technical aspects and recommendations on methodological approaches. Nuklearmedizin 2012; 51: 140-153 (NKI)

1546. Thuijs NB, Uitdehaag BMJ, Van Ouwerkerk WJR, van der Valk P, Vandertop WP, Peerdeman SM. Pediatric meningiomas in The Netherlands 1974-2010: a descriptive epidemiological case study. Childs Nervous System 2012; 28: 1009-1015. (VUmc)

1547. Thunnissen E, Beasley MB, Borczuk AC, Brambilla E, Chirieac LR, Dacic S, Flieder D, Gazdar A, Geisinger K, Hasleton P, Ishikawa Y, Kerr KM, Lantejoul S, Matsuno Y, Minami Y, Moreira AL, Motoi N, Nicholson AG, Noguchi M, Nonaka D, Pelosi G, Petersen I, Rekhtman N, Roggli V, Travis WD, Tsao MS, Wistuba I, Xu HD, Yatabe Y, Zakowski M, Witte B, Kuik DJ. Reproducibility of histopathological subtypes and invasion in pulmonary adenocarcinoma. An international interobserver study. Modern Pathology 2012; 25: 1574-1583. (VUmc)

1548. Thunnissen E, Boers E, Heideman DAM, Grunberg K, Kuik DJ, Noorduin A, van Oosterhout M, Pronk D, Seldenrijk C, Sietsma H, Smit EF, van Suylen R, von der Thusen J, Vrugt B, Wiersma A, Witte BI, den Bakker M. Correlation of immunohistochemical staining p63 and TTF-1 with EGFR and K-ras mutational spectrum and diagnostic reproducibility in non small cell lung carcinoma. Virchows Archiv 2012; 461: 629-638. (VUmc)

1549. Thunnissen E, Bubendorf L, Dietel M, Elmberger G, Kerr K, Lopez-Rios F, Moch H, Olszewski W, Pauwels P, Penault-Llorca F, Rossi G. EML4-ALK testing in non-small cell carcinomas of the lung: a review with recommendations. Virchows Archiv 2012; 461: 245-257. (VUmc)

1550. Thunnissen E, Kerr KM, Herth FJF, Lantuejoul S, Papotti M, Rintoul RC, Rossi G, Skov BG, Weynand B, Bubendorf L, Katrien G, Johansson L, Lopez-Rios F, Ninane V, Olszewski W, Popper H, Jaume S, Schnabel P, Thiberville L, Laenger F. The challenge of NSCLC diagnosis and predictive analysis on small samples. Practical approach of a working group. Lung Cancer 2012; 76: 1-18. (VUmc)


1551. Thunnissen F, Prinsen C, Hol B, Van der Drift M, Vesin A, Brambilla C, Montuenga L, Field J. Smoking history and lung carcinoma: KRAS mutation is an early hit in lung adenocarcinoma development. Lung Cancer 2012; 75: 156-160. (VUmc)

1552. Thyssen JP, Sosted H, Uter W, Schnuch A, Gimenez-Arnau AM, Vigan M, Rustemeyer T, Granum B, McFadden J, White JM, White IR, Goossens A, Menne T, Liden C, Johansen JD. Self-testing for contact sensitization to hair dyes - scientific considerations and clinical concerns of an industry-led screening programme. Contact Dermatitis 2012; 66: 300-311. (VUmc)

1553. Tiacci E, Döring C, Brune V, van Noesel CJM, Klapper W, Mechtersheimer G, Falini B, Küppers R, Hansmann ML. Analyzing primary Hodgkin and Reed-Sternberg cells to capture the molecular and cellular pathogenesis of classical Hodgkin lymphoma. Blood 2012; 120(23): 4609-4620. (AMC)

1554. Tian S, Roepman P, Popovici V, Michaut M, Majewski I, Salazar R, Santos C, Rosenberg R, Nitsche U, Mesker WE, Bruin S, Tejpar S, Delorenzi M, Bernards R, Simon I. A robust genomic signature for the detection of colorectal cancer patients with microsatellite instability phenotype and high mutation frequency. J Pathol. 2012 (NKI)

1555. Tibaldi C, Giovannetti E, Tiseo M, Leon LG, D'Incecco A, Loosekoot N, Bartolotti M, Honeywell R, Cappuzzo F, Ardizzoni A, Peters GJ. Correlation of cytidine deaminase polymorphisms and activity with clinical outcome in gemcitabine-/platinum-treated advanced non-small-cell lung cancer patients. Annals of Oncology 2012; 23: 670-677. (VUmc)

1556. Tielemans MM, van Oijen MGH, Mulder CJJ, Vos KJ, Lems WF. Esomeprazole relieves upper gastrointestinal symptoms in high-risk and average-risk NSAID users in daily clinical practice: results from an open-label study. European Journal of Gastroenterology & Hepatology 2012; 24: 281-287. (VUmc)

1557. Timmermans AJ, Krap M, Hilgers FJM, van den Brekel MWM. Spraakrevalidatie na totale laryngectomie. Ned Tijdschr Tandheelk 2012; 119: 357-61 (NKI)

1558. Timmermans AJ, van den Brekel MWM, van der Molen L, Navran A, Nijssen TF, Hilgers FJM. Nieuwe ontwikkelingen op het gebied van zorg en nazorg van hoofd-halskanker. Ned Tijdschr Geneeskd 2012; 156: 1719-24 (NKI)

1559. Timmers JM, den Heeten GJ, Adang EM, Otten JD, Verbeek AL, Broeders MJ. Dutch digital breast cancer screening: implications for breast cancer care. European Journal Of Public Health 2012; 22(6): 925-929. (AMC)

1560. Timmers JM, Doorne-Nagtegaal HJ, Zonderland HM, van Tinteren H, Visser O, Verbeek AL, den Heeten GJ, Broeders MJ. The Breast Imaging Reporting and Data System (BI-RADS) in the Dutch breast cancer screening programme: its role as an assessment and stratification tool. EurRadiol 2012; 22: 1717-1723 (NKI/AMC)

1561. Timmers JMH, van Doorne-Nagtegaal HJ, Verbeek ALM, den Heeten GJ, Broeders MJM. A dedicated BI-RADS training programme: effect on the inter-observer variation among screening radiologists. European Journal Of Radiology 2012; 81(9): 2184-2188. (AMC)

1562. Timmers L, Beckeringh JJ, van Herk-Sukel MPP, Boven E, Hugtenburg JG. Use and costs of oral anticancer agents in the Netherlands in the period 2000-2008. Pharmacoepidemiology and Drug Safety 2012; 21: 1036-1044. (VUmc)

1563. Timmers L, Swart EL, Boons CCLM, Mangnus D, van de Ven PM, Peters GJ, Boven E, Hugtenburg JG. The use of capecitabine in daily practice: a study on adherence and patients' experiences. Patient Preference and Adherence 2012; 6: 741-748. (VUmc)

1564. Tiseo M, Giovannetti E, Tibaldi C, Camerini A, Di Costanzo F, Barbieri F, Burgers JA, Vincent A, Peters GJ, Smit EF, Ardizzoni A. Pharmacogenetic study of patients with advanced non-small cell lung cancer (NSCLC) treated with second-line pemetrexed or pemetrexed-carboplatin. Lung Cancer 2012; 78: 92-9 (NKI/VUmc)

1565. Tol JAMG, Broekman MC, Brauers MAL, van Gulik TM, Busch ORC, Gouma DJ. Betrouwbaarheid dataregistratie van complexe patiënten: invloed op het gestandaardiseerde ziekenhuissterftecijfer (HSMR). Nederlands Tijdschrift Voor Geneeskunde 2012; 156(49): A4918-. (AMC)

1566. Tol JAMG, Busch ORC, van der Gaag NA, van Gulik TM, Gouma DJ. The Quandary of Preresection Biliary Drainage for Pancreatic Cancer. Cancer Journal 2012; 18(6): 550-554. (AMC)

1567. Tol JAMG, van Gulik TM, Busch ORC, Gouma DJ. Centralization of Highly Complex Low-Volume Procedures in Upper Gastrointestinal Surgery. A Summary of Systematic Reviews and Meta-Analyses. Digestive Surgery 2012; 29(5): 374-383. (AMC)

1568. Tolcher AW, Quinn DI, Ferrari A, Ahmann F, Giaccone G, Drake T, Keating A, de Bono JS. A phase II study of YM155, a novel small-molecule suppressor of survivin, in castration-resistant taxane-pretreated prostate cancer. Annals of Oncology 2012; 23: 968-9U9. (VUmc)

1569. Tolhuis B, Blom M, van Lohuizen M. Chromosome conformation capture on chip in single Drosophila melanogaster tissues. Methods 2012; 58: 231-42 (NKI)

1570. Tomasson G, Boers M, Walsh M, LaValley M, Cuthbertson D, Carette S, Davis JC, Hoffman GS, Khalidi NA, Langford CA, McAlear CA, Mccune WJ, Monach PA, Seo P, Specks U, Spiera R, St Clair EW, Stone JH, Ytterberg SR, Merkel PA. Assessment of health-related quality of life as an outcome measure in granulomatosis with polyangiitis (Wegener's). Arthritis Care & Research 2012; 64: 273-279. (VUmc)

1571. Tombal B, Ameye F, de la Taille A, de Reijke T, Gontero P, Haese A, Kil P, Perrin P, Remzi M, Schröder J, Speakman M, Volpe A, Meesen B, Stoevelaar H. Biopsy and treatment decisions in the initial management of prostate cancer and the role of PCA3; a systematic analysis of expert opinion. World Journal Of Urology 2012; 30(2): 251-256. (AMC)

1572. Tomé S, Simard JP, Slean MM, Holt I, Morris GE, Wojciechowicz K, Te Riele H, Pearson CE. Tissue-specific mismatch repair protein expression: MSH3 is higher than MSH6 in multiple mouse tissues. DNA Repair 2012 (NKI)

1573. Tomosugi M, Sowa Y, Yasuda S, Tanaka R, Te Riele H, Ikawa H, Koyama M, Sakai T. RB independent G1-phase arrest by flavone, phosphatidylinositol 3-kinase inhibitor and histone deacetylase inhibitor. Cancer Sci 2012; 103: 2139-43 (NKI)

1574. Tonelli R, McIntyre A, Camerin C, Walters ZS, Di Leo K, Selfe J, Purgato S, Missiaglia E, Tortori A, Renshaw J, Astolfi A, Taylor KR, Serravalle S, Bishop R, Nanni C, Valentijn LJ, Faccini A, Leuschner I, Formica S, Reis-Filho JS, Ambrosini V, Thway K, Franzoni M, Summersgill B, Marchelli R, Hrelia P, Cantelli-Forti G, Fanti S, Corradini R, Pession A, Shipley J. Antitumor activity of sustained N-myc reduction in rhabdomyosarcomas and transcriptional block by antigene therapy. Clinical Cancer Research 2012; 18(3): 796-807. (AMC)

1575. Tonino SH, van de Berg PJ, Yong SL, ten Berge IJ, Kersten MJ, van Lier RAW, van Oers MH, Kater AP. Expansion of effector T cells associated with decreased PD-1 expression in patients with indolent B cell lymphomas and chronic lymphocytic leukemia. Leukemia & Lymphoma 2012; 53(9): 1785-1794.

1576. Topolnjak R, Borst GR, Nijkamp J, Sonke JJ. Image-guided Radiotherapy for Left-sided Breast Cancer Patients: Geometrical Uncertainty of the Heart. Int J Radiat Oncol Biol Phys 2012; 82: 647-55 (NKI)


1577. Tossberg JT, Crooke PS, Henderson MA, Sriram S, Mrelashvili D, Chitnis S, Polman C, Vosslamber S, Verweij CL, Olsen NJ, Aune TM. Gene-expression signatures: biomarkers toward diagnosing multiple sclerosis. Genes and Immunity 2012; 13: 146-154. (VUmc)

1578. Tournoy KG, Keller SM, Annema JT. Mediastinal staging of lung cancer: novel concepts. Lancet Oncology 2012; 13(5): E221-E229. (AMC)

1579. Tracy SI, Kakalacheva K, Luenemann JD, Luzuriaga K, Middeldorp JM, Thorley-Lawson DA. Persistence of Epstein-Barr Virus in Self-Reactive Memory B Cells. Journal of Virology 2012; 86: 12330-12340. (VUmc)

1580. Tran L, Huitema A, Vogel W, Baars J. Lack of tumor uptake of 131-I labeled rituximab in a patient with a CD20 positive lymphoma lesion. J Oncol Pharm Pract 2012; 18: 417-420 (NKI)

1581. Tran L, Huitema A, Vogel W, Beijnen J, Baars J. Lack of tumor uptake of 131-I labeled rituximab in a patient with a CD20 positive lymphoma lesion. J Oncol Pharm Pract 2012; 18: 417-420 (NKI)

1582. Tromp JM, Geest CR, Breij ECW, Elias JA, van Laar J, Luijks DM, Kater AP, Beaumont T, van Oers MHJ, Eldering E. Tipping the Noxa/Mcl-1 balance overcomes ABT-737 resistance in chronic lymphocytic leukemia. Clinical Cancer Research 2012; 18(2): 487-498. (AMC)

1583. Truong HT, Ramos AM, Yalcin F, de Ruiter M, van der Poel HJ, Huvenaars KH, et al. Sequence-based genotyping for marker discovery and co-dominant scoring in germplasm and populations. PloS one 2012; 7: e37565 (NKI)

1584. Tsang CM, Yip YL, Lo KW, Deng W, To KF, Hau PM, Lau VMY, Takada K, Lui VWY, Lung ML, Chen H, Zeng M, Middeldorp JM, Cheung ALM, Tsao SW. Cyclin D1 overexpression supports stable EBV infection in nasopharyngeal epithelial cells. Proceedings of the National Academy of Sciences of the United States of America 2012; 109: E3473-E3482. (VUmc)

1585. Tuijthof GJM, Pontesilli M, van der Zwaag H, Jonges R, de Geer SG van, Maas M, Blankevoort L. A novel foot plate to assess 3D range of motion of the hindfoot. International Journal Of Industrial Ergonomics 2012; 42(1): 41-48. (AMC)

1586. Turker P, Bostrom PJ, Wroclawski ML, van Rhijn B, Kortekangas H, Kuk C, et al. Upstaging of urothelial cancer at the time of radical cystectomy: factors associated with upstaging and its effect on outcome. BJU Int 2012; 110: 804-11 (NKI)

1587. Tzartos JS, Khan G, Vossenkamper A, Cruz-Sadaba M, Lonardi S, Sefia E, Meager A, Elia A, Middeldorp JM, Clemens M, Farrell PJ, Giovannoni G, Meier UC. Association of innate immune activation with latent Epstein-Barr virus in active MS lesions. Neurology 2012; 78: 15-23. (VUmc)

1588. Ubbink DT, Visser A, Gouma DJ, Goslings JC. Registration of surgical adverse outcomes: a reliability study in a university hospital. BMJ Open 2012; 2(3): e000891-. (AMC)

1589. Unger WWJ, Pearson T, Abreu JRF, Laban S, van der Slik AR, Mulder-van der Kracht S, Kester MGD, Serreze DV, Shultz LD, Griffioen M, Drijfhout JW, Greiner DL, Roep BO. Islet-Specific CTL Cloned from a Type 1 Diabetes Patient Cause Beta-Cell Destruction after Engraftment into HLAA2 Transgenic NOD/SCID/IL2RG Null Mice. PloS one 2012; 7: . (VUmc)

1590. Unger WWJ, van Beelen AJ, Bruijns SC, Joshi M, Fehres CM, van Bloois L, Verstege MI, Ambrosini M, Kalay H, Nazmi K, Bolscher JG, Hooijberg E, de Gruijl TD, Storm G, van Kooyk Y. Glycan-modified liposomes boost CD4(+) and CD8(+) T-cell responses by targeting DC-SIGN on dendritic cells. Journal of Controlled Release 2012; 160: 88-95. (VUmc)

1591. Uphoff EPMM, Wennekes L, Punt CJA, Grol RPTM, Wollersheim HCH, Hermens RPMG, Ottevanger PB. Development of generic quality indicators for patient-centered cancer care by using a RAND modified Delphi method. Cancer Nursing 2012; 35(1): 29-37. (AMC)

1592. Uter W, Aberer W, rmario-Hita JC, Fernandez-Vozmediano JM, Ayala F, Balato A, Bauer A, Ballmer-Weber B, Beliauskiene A, Fortina AB, Bircher A, Brasch J, Chowdhury MMU, Coenraads PJ, Schuttelaar ML, Cooper S, Czarnecka-Operacz M, Zmudzinska M, Elsner P, English JSC, Frosch PJ, Fuchs T, Garcia-Gavin J, Fernandez-Redondo V, Gawkrodger DJ, Gimenez-Arnau A, Green CM, Horne HL, Johansen JD, Jolanki R, Pesonen M, King CM, Krecisz B, Chomiczewska D, Kiec-Swierczynska M, Larese F, Mahler V, Ormerod AD, Peserico A, Rantanen T, Rustemeyer T, Sanchez-Perez J, Sansom JE, Silvestre JF, Simon D, Spiewak R, Statham BN, Stone N, Wilkinson M, Schnuch A. Current patch test results with the European baseline series and extensions to it from the 'European Surveillance System on Contact Allergy' network, 2007-2008. Contact Dermatitis 2012; 67: 9-19. (VUmc)

1593. Uusi-Rauva K, Kyttälä A, van der Kant R, Vesa J, Tanhuanpää K, Neefjes J, Olkkonen VM, Jalanko A. Neuronal ceroid lipofuscinosis protein CLN3 interacts with motor proteins and modifies location of late endosomal compartments. Cell Mol Life Sci 2012; 69: 2075-89 (NKI)

1594. Uyterlinde W, Chen C, de Bois J, Kwint M, Belderbos J, Sonke J.J, van den Heuvel M. Clinical and dosimetric parameters for acute esophagus toxicity in concurrent chemotherapy and Intensity Modulated radiotherapy for locally advanced non-small cell lung cancer. International Journal of Radiation Oncology *Biology* Physics. 2012 (NKI)

1595. Uyterlinde W, Zimmerman M, Belderbos J, Kwint M, Burgers S, van den Heuvel M. Bij lokaal gevorderd niet-kleincellig longcarcinoom - Gelijktijdige chemoradiatie Oncologica 2012; 29: 30-3 (NKI)

1596. Uzun S, Djamin RS, Kluytmans JA, Van't Veer NE, Ermens AA, Pelle AJ, Mulder P, van der Eerden MM, Aerts JGJV. Influence of macrolide maintenance therapy and bacterial colonisation on exacerbation frequency and progression of COPD (COLUMBUS): Study protocol for a randomised controlled trial. Trials 2012; 13: . (VUmc)

1597. Valdés Olmos RA, Brouwer OR, Feenstra C. De schildwachtklier procedure en SPECT-CT. Gamma Professional 2012; 62: 13-18 (NKI)

1598. Valean S, Mulder CJJ, Pascu O, Stanciu C, Diculescu MM, Tantau M, Sporea I, Ciulean TE, Mircea PA. WGO Digestive Oncology Task Force: Validation of Hepatogastroenterologist Practice in Oncology. Journal of Gastrointestinal and Liver Diseases 2012; 21: 239-242. (VUmc)

1599. Valent P, Bonnet D, De Maria R, Lapidot T, Copland M, Melo JV, Chomienne C, Ishikawa F, Schuringa JJ, Stassi G, Huntly B, Herrmann H, Soulier J, Roesch A, Schuurhuis GJ, Wohrer S, Arock M, Zuber J, Cerny-Reiterer S, Johnsen HE, Andreeff M, Eaves C. Cancer stem cell definitions and terminology: the devil is in the details. Nature Reviews Cancer 2012; 12: 767-775. (VUmc)

1600. Valentijn LJ, Koster J, Haneveld F, Ait Aissa R, van Sluis P, Broekmans MEC, Molenaar JJ, van Nes J, Versteeg R. Functional MYCN signature predicts outcome of neuroblastoma irrespective of MYCN amplification. Proceedings Of The National Academy Of Sciences Of The United States Of America 2012; 109(47): 19190-19195. (AMC)

1601. van Abel D, Abdulhamid O, Scheper W, van Dijk M, Oudejans CBM. STOX1A induces phosphorylation of tau proteins at epitopes hyperphosphorylated in Alzheimer's disease. Neuroscience Letters 2012; 528(2): 104-109. (AMC)

1602. van Alkemade H, de Leau M, Dieleman EM, Kardaun JW, van Os R, Vandertop WP, van Furth WR, Stalpers LJ. Impaired survival and long-term neurological problems in benign meningioma. Neuro-Oncology 2012; 14: 658-666. (VUmc/AMC)


1603. van As JW, van den Berg H, van Dalen EC. Medical interventions for the prevention of platinum-induced hearing loss in children with cancer. Cochrane Database Of Systematic Reviews 2012; 2012(5): CD009219-. (AMC)

1604. van Asseldonk DP, Seinen ML, De Boer NKH, van Bodegraven AA, Mulder CJ. Hepatotoxicity associated with 6-methyl mercaptopurine formation during azathioprine and 6-mercaptopurine therapy does not occur on the short-term during 6-thioguanine therapy in IBD treatment. Journal of Crohns & Colitis 2012; 6: 95-101. (VUmc)

1605. van Asseldonk DP, Tack GJ, van Wanrooij RLJ, van Bodegraven AA, Mulder CJ. Commentary: tioguanine in the treatment of refractory coeliac disease - authors' reply. Alimentary Pharmacology & Therapeutics 2012; 36: 595-596. (VUmc)

1606. van Assema DM, Lubberink M, Boellaard R, Schuit RC, Windhorst AD, Scheltens P, van Berckel BN, Lammertsma AA. Reproducibility of quantitative (R)-[11C]verapamil studies. Eur J Nucl Med Mol Imaging 2012; 2: 1. (VUmc)

1607. van Beek EM, Zarate JA, van Bruggen R, Schornagel K, Tool ATJ, Matozaki T, Kraal G, Roos D, van den Berg TK. SIRPalpha controls the activity of the phagocyte NADPH oxidase by restricting the expression of gp91(phox). Cell Reports 2012; 2: 748-755. (VUmc)

1608. Van Bemmel JG, Filion GJ, Rosado A, Talhout W, de Haas M, van Welsem T, van Leeuwen F, van Steensel B. A network model of the molecular organization of chromatin in Drosophila. Mol Cell.2013; 49: 759-771 (NKI)

1609. van Bokhorst-de van der Schueren M, Konijn NPC, Bultink IEM, Lems WF, Earthman CP, van Tuyl LHD. Relevance of the new pre-cachexia and cachexia definitions for patients with rheumatoid arthritis. Clinical Nutrition 2012; 31: 1008-1010. (VUmc)

1610. van Bokhorst-de van der Schueren M, Roosemalen MM, Weijs PJ, Langius JA. High Waste Contributes to Low Food Intake in Hospitalized Patients. Nutrition in Clinical Practice 2012; 27: 274-280. (VUmc)

1611. van Breest Smallenburg V, Duijm LEM, den Heeten GJ, Groenewoud JH, Jansen FH, Fracheboud J, Plaisier ML, van Doorne-Nagtegaal HJ, Broeders MJM. Two-view versus single-view mammography at subsequent screening in a region of the Dutch breast screening programme. European Journal Of Radiology 2012; 81(9): 2189-2194. (AMC)

1612. van Brunschot S, Bakker OJ, Besselink MG, Bollen TL, Fockens P, Gooszen HG, van Santvoort HC. Treatment of necrotizing pancreatitis. Clinical Gastroenterology And Hepatology 2012; 10(11): 1190-1201. (AMC)

1613. van Brunschot S, van Santvoort HC, Gooszen HG, Fockens P. Endoscopische versus chirurgische behandeling van geïnfecteerde necrotiserende pancreatitis: de TENSION-studie. Nederlands Tijdschrift Voor Geneeskunde 2012; 156(4): A4329-. (AMC)

1614. van Cleef BA, van Rijen MML, Ferket M, Kluytmans JA. Self-sampling is appropriate for detection of Staphylococcus aureus: a validation study. Antimicrob Resist Infect Control 2012; 1: 34. (VUmc)

1615. van Cleef BAGL, Kluytmans JAJW, van Benthem BHB, Haenen A, Monen J, niels-Haardt I, Jurke A, Friedrich AW. Cross Border Comparison of MRSA Bacteraemia between The Netherlands and North Rhine-Westphalia (Germany): A Cross-Sectional Study. PloS one 2012; 7: . (VUmc)

1616. Van Cutsem, Tejpar S, Vanbeckevoort D, Peeters M, Humblet Y, Gelderblom H, Vermorken JB, Viret F, Glimelius B, Gallerani E, Hendlisz A, Cats A, Moehler M, Sagaert X, Vlassak S, Schlichting M, Ciardiello F. Intrapatient cetuximab dose-escalation in metastatic colorectal cancer according to the grade of early skin reactions: the randomized EVEREST study. JCO 2012; 30: 2861-8 (NKI)

1617. van Dalen EC, Mank A, Leclercq E, Mulder RL, Davies M, Kersten MJ, van de Wetering MD. Low bacterial diet versus control diet to prevent infection in cancer patients treated with chemotherapy causing episodes of neutropenia. Cochrane Database Of Systematic Reviews 2012; 2012(9): CD006247-. (AMC)

1618. van Dam RM, Wong-Lun-Hing EM, van Breukelen GJP, Stoot JHMB, van der Vorst JR, Bemelmans MHA, Olde Damink SWM, Lassen K, Dejong CHC. Open versus laparoscopic left lateral hepatic sectionectomy within an enhanced recovery ERAS® programme (ORANGE II-trial): study protocol for a randomised controlled trial. Trials 2012; 13: 54-. (AMC)

1619. van de Giessen M, Foumani M , Vos FM, Strackee SD, Maas M, van Vliet LJ, Grimbergen CA, Streekstra GJ. A 4D statistical model of wrist bone motion patterns. Ieee Transactions On Medical Imaging 2012; 31(3): 613-625. (AMC)

1620. van de Giessen M, Vos FM, Grimbergen CA, van Vliet LJ, Streekstra GJ. An efficient and robust algorithm for parallel groupwise registration of bone surfaces. Medical Image Computing And Computer-Assisted Intervention 2012; 15(Part 3): 164-171. (AMC)

1621. van de Giessen M, Vos FM, Grimbergen CA, van Vliet LJ, Streekstra GJ. Groupwise rigid registration of wrist bones. Medical Image Computing And Computer-Assisted Intervention 2012; 15(Part 2): 155-162. (AMC)

1622. van de Klundert MAA, van Hemert FJ, Zaaijer HL, Kootstra NA. The Hepatitis B Virus X Protein Inhibits Thymine DNA Glycosylase Initiated Base Excision Repair. Plos One 2012; 7(11): e48940-. (AMC)

1623. van de Lande J, von Mensdorff-Pouilly S, Lettinga RG, Piek JM, Verheijen RHM. Open Versus Laparoscopic Pelvic Lymph Node Dissection in Early Stage Cervical Cancer No Difference in Surgical or Disease Outcome. International Journal of Gynecological Cancer 2012; 22: 107-114. (VUmc)

1624. van de Sande MGH, van der Leij C, Lavini C, Wijbrandts CA, Maas M, Tak PP. Characteristics of synovial inflammation in early arthritis analysed by pixel-by-pixel time-intensity curve shape analysis. Rheumatology 2012; 51(7): 1240-1245. (AMC)

1625. Van de Schans SA, Aben KK, Mulders PF, Haanen JB, van Herpen C, Verhoeven RH, Karim-Kos HE, Oosterwijk E, Kiemeney LA. Modest improvement in 20 years of kidney cancer care in the Netherlands. Eur J Cancer 2012; 48: 1822-30 (NKI)

1626. van de Schans SAM, Issa DE, Visser O, Nooijen P, Huijgens PC, Karim-Kos HE, Janssen-Heijnen MLG, Coebergh JWW. Diverging trends in incidence and mortality, and improved survival of non-Hodgkin's lymphoma, in the Netherlands, 1989-2007. Annals of Oncology 2012; 23: 171-U512. (VUmc)

1627. van de Stadt LA, van Schaardenburg D. Alcohol consumption protects against arthritis development in seropositive arthralgia patients. Annals of the Rheumatic Diseases 2012; 71: 1431-1432. (VUmc)

1628. van de Stadt LA, van Sijl AM, van Schaardenburg D, Nurmohamed MT. Dyslipidaemia in patients with seropositive arthralgia predicts the development of arthritis. Annals of the Rheumatic Diseases 2012; 71: 1915-1916. (VUmc)

1629. Van de Steeg E, Stránecký V, Hartmannová H, Nosková L, H ebí ek M, Wagenaar E, van Esch A, de Waart DR, Oude Elferink RP, Kenworthy KE, Sticová E, al-Edreesi M, Knisely AS, Kmoch S, Jirsa M, Schinkel AH. Complete OATP1B1 and OATP1B3 deficiency causes human Rotor syndrome by interrupting conjugated bilirubin reuptake into the liver. J Clin Invest 2012; 122: 519-28 (NKI)


1630. van de Ven R, Lindenberg JJ, Reurs AW, Scheper RJ, Scheffer GL, de Gruijl TD. Preferential Langerhans cell differentiation from CD34(+) precursors upon introduction of ABCG2 (BCRP). Immunology and Cell Biology 2012; 90: 206-215. (VUmc)

1631. van de Ven R, Reurs AW, Wijnands PGJT, van Wetering S, Kruisbeek AM, Hooijberg E, Scheffer GL, Scheper RJ, de Gruijl TD. Exposure of CD34(+) precursors to cytostatic anthraquinone-derivatives induces rapid dendritic cell differentiation: implications for cancer immunotherapy. Cancer Immunology Immunotherapy 2012; 61: 181-191. (VUmc)

1632. Van de Vijver P, Scheer L, van Beijnum J, Griffioen A, Hackeng TM. Application of an omonasteine ligation strategy for the total chemical synthesis of the BRD7 bromodomain. Chemical Communications 2012; 48: 9403-9405. (VUmc)

1633. Van de Wetering JK, Sapthu S. ABCG2 functions as a general 1634. van de Wetering MD, D'Angio G, Caron H. Obituary of a very special doctor, Dr Jan de Kraker (October 18, 1944 to

January 19, 2012). Journal Of Pediatric Hematology Oncology 2012; 34(4): 245-246. (AMC) 1635. van Dellen E, Douw L, Hillebrand A, Ris-Hilgersom IHM, Schoonheim MM, Baayen JC, De Witt Hamer PC, Velis DN,

Klein M, Heimans JJ, Stam CJ, Reijneveld JC. MEG Network Differences between Low- and High-Grade Glioma Related to Epilepsy and Cognition. PloS one 2012; 7: e50122. (VUmc)

1636. van den Akker J, van Weert A, Afink G, Bakker ENTP, van der Pol E, Böing AN, Nieuwland R, VanBavel E. Transglutaminase 2 is secreted from smooth muscle cells by transamidation-dependent microparticle formation. Amino Acids 2012; 42(2-3): 961-973. (AMC)

1637. van den Berg H, van den Anker JN, Beijnen JH. Cytostatic drugs in infants: A review on pharmacokinetic data in infants. Cancer Treatment Reviews 2012; 38(1): 3-26. (AMC)

1638. van den Berg MH, Overbeek A, van Dulmen-den Broeder E, Lambalk CB. Comment on: Li HW, Wong CY, Yeung WS, Ho PC, Ng EH. Serum anti-Mullerian hormone level is not altered in women using hormonal contraceptives. Contraception 2011;83:582-5. Contraception 2012; 85: 519-520. (VUmc)

1639. Van den Berg NS, Brouwer OR, Klop WMC, Karakullukcu B, Zuur CL, Tan IB, Balm AJM, van den Brekel MWM, Valdés Olmos RA, van Leeuwen FW. Concomitant radio- and fluorescenceguided sentinel lymph node biopsy in squamous cell carcinoma of the oral cavity using ICG-(99m)Tc-nanocolloid. Eur J Nucl Med Mol Imaging 2012; 39: 1128-36 (NKI)

1640. Van den Berg NS, van Leeuwen FW, van der Poel HG. Fluorescence guidance in urologic surgery. Curr Opin Urol 2012; 22: 109-20 (NKI)

1641. van den Berg T, Engelhardt EG, Haanstra TM, Langius JA, van Tulder MW. Comment on van den Berg et al: "Methodology of Clinical Nutrition Guidelines for Adult Cancer Patients: How Good Are They According to AGREE Criteria?" Comment. Journal of Parenteral and Enteral Nutrition 2012; 36: 504-505. (VUmc)

1642. van den Berg T, Engelhardt EG, Haanstra TM, Langius JA, van Tulder MW. Methodology of Clinical Nutrition Guidelines for Adult Cancer Patients: How Good Are They According to AGREE Criteria?. Journal of Parenteral and Enteral Nutrition 2012; 36: 316-322. (VUmc)

1643. van den Boezem PB, Kruyt PM, Cuesta MA, Sietses C. Single-Incision Versus Conventional Laparoscopic Cholecystectomy: a Case Control Study. Acta Chirurgica Belgica 2012; 112: 374-377. (VUmc)

1644. Van den Brekel MW, Lodder WL, Stel HV, Bloemena E, Leemans CR, Van der Waal I. Observer variation in the histopathologic assessment of extranodal tumorspread in lymph node metastases in the neck. Head Neck 2012; 34: 840-5 (VUmc/NKI)

1645. van den Broek EC, Kater AP, van de Schans SAM, Karim-Kos HE, Janssen-Heijnen MLG, Peters WG, Nooijen PTGA, Coebergh JWW, Posthuma EFM. Chronic Lymphocytic Leukaemia in the Netherlands: Trends in incidence, treatment and survival, 1989-2008. European Journal Of Cancer 2012; 48(6): 889-895. (AMC)

1646. van den Broek LJ, Niessen FB, Scheper RJ, Gibbs S. Development, validation and testing of a human tissue engineered hypertrophic scar model. Altex 2012; 29: 389-402. (VUmc)

1647. van den Broek M, Dirven L, de Vries-Bouwstra JK, Dehpoor AJ, Goekoop-Ruiterman YPM, Gerards AH, Kerstens PJSM, Huizinga TWJ, Lems WF, Allaart CF. Rapid radiological progression in the first year of early rheumatoid arthritis is predictive of disability and joint damage progression during 8 years of follow-up. Annals of the Rheumatic Diseases 2012; 71: 1530-1533. (VUmc)

1648. van den Broek M, Dirven L, Klarenbeek NB, Molenaar THE, Han KH, Kerstens PJSM, Huizinga TWJ, Dijkmans BAC, Allaart CF. The association of treatment response and joint damage with ACPA-status in recent-onset RA: a subanalysis of the 8-year follow-up of the BeSt study. Annals of the Rheumatic Diseases 2012; 71: 245-248. (VUmc)

1649. van den Broek M, Lems WF, Allaart CF. BeSt practice: the success of early-targeted treatment in rheumatoid arthritis. Clinical and Experimental Rheumatology 2012; 30: S35-S38. (VUmc)

1650. van den Broek M, Lems WF, Allaart CF. Do we need guidelines to stop as well as to start biological therapies for rheumatoid arthritis?. Clinical and Experimental Rheumatology 2012; 30: S21-S26. (VUmc)

1651. van den Eertwegh AJM, Versluis J, van den Berg HP, Santegoets SJAM, van Moorselaar RJA, van der Sluis TM, Gall HE, Harding TC, Jooss K, Lowy I, Pinedo HM, Scheper RJ, Stam AGM, von Blomberg BME, de Gruijl TD, Hege K, Sacks N, Gerritsen WR. Combined immunotherapy with granulocyte-macrophage colony-stimulating factor-transduced allogeneic prostate cancer cells and ipilimumab in patients with metastatic castration-resistant prostate cancer: a phase 1 dose-escalation trial. Lancet Oncology 2012; 13: 509-517. (VUmc)

1652. van den Esschert JW, van Lienden KP, Alles LK, van Wijk AC, Heger M, Roelofs JJ, van Gulik TM. Liver regeneration after portal vein embolization using absorbable and permanent embolization materials in a rabbit model. Annals Of Surgery 2012; 255(2): 311-318. (AMC)

1653. van den Hout MFCM, Koster BD, Sluijter BJR, van Leeuwen PAM, Meijer S, van den Tol MP, van den Eertwegh AJM, Scheper RJ, van de Ven R, de Gruijl TD. Response Breslow thickness and excision interval affect the activation state of Langerhans cells in melanoma sentinel lymph nodes. Blood 2012; 119: 4809-4810. (VUmc)

1654. van den Munckhof P, Christiaans I, Kenter SB, Baas F, Hulsebos TJM. Germline SMARCB1 mutation predisposes to multiple meningiomas and schwannomas with preferential location of cranial meningiomas at the falx cerebri. Neurogenetics 2012; 13(1): 1-7. (AMC)

1655. van Denderen JC, Blom GJ, van der Horst-Bruinsma I, Dijkmans BAC, Nurmohamed MT. Elevated liver enzymes in patients with ankylosing spondylitis treated with etanercept. Clinical Rheumatology 2012; 31: 1677-1682. (VUmc)

1656. van der Aa LB, Lutter R, Heymans HSA, Smids BS, Dekker T, van Aalderen WMC, Sillevis Smitt JH, Knippels LMJ, Garssen J, Nauta AJ, Sprikkelman AB. No detectable beneficial systemic immunomodulatory effects of a specific synbiotic mixture in infants with atopic dermatitis. Clinical And Experimental Allergy 2012; 42(4): 531-539. (AMC)


1657. van der Bij S, Koffijberg H, Burgers JA, Baas P, van de Vijver MJ, de Mol BAJM, Moons KGM. Prognosis and prognostic factors of patients with mesothelioma: a population-based study. British Journal Of Cancer 2012; 107(1): 161-164. (AMC/NKI)

1658. van der Burg LRA, ter Wee MM, Boonen A. Effect of biological therapy on work participation in patients with ankylosing spondylitis: a systematic review. Annals of the Rheumatic Diseases 2012; 71: 1924-1933. (VUmc)

1659. van der Does AM, Hensbergen PJ, Bogaards SJ, Cansoy M, Deelder AM, van Leeuwen HC, Drijfhout JW, van Dissel JT, Nibbering PH. The Human Lactoferrin-Derived Peptide hLF1-11 Exerts Immunomodulatory Effects by Specific Inhibition of Myeloperoxidase Activity. J Immunol 2012; 188: 5012-5019. (VUmc)

1660. van der Does AM, Joosten SA, Vroomans E, Bogaards SJP, van Meijgaarden KE, Ottenhoff THM, van Dissel JT, Nibbering PH. The Antimicrobial Peptide hLF1-11 Drives Monocyte-Dendritic Cell Differentiation toward Dendritic Cells That Promote Antifungal Responses and Enhance Th17 Polarization. Journal of Innate Immunity 2012; 4: 284-292. (VUmc)

1661. Van der Drift MA, Karim-Kos HE, Siesling S, Groen HJ, Wouters MW, Coebergh JW, de Vries E, Janssen- Heijnen ML. Progress in standard of care therapy and modest survival benefits in the treatment of nonsmall cell lung cancer patients in the Netherlands in the last 20 years. J Thorac Oncol 2012; 7: 291-8 (NKI)

1662. van der Drift MA, Prinsen CFM, Knuiman GJ, Janssen JP, Dekhuijzen PNR, Thunnissen FBJM. Diagnosing Peripheral Lung Cancer: The Additional Value of the Ras-Association Domain Family 1A Gene Methylation and Kirsten Rat Sarcoma 2 Viral Oncogene Homolog Mutation Analyses in Washings in Nondiagnostic Bronchoscopy. Chest 2012; 141: 169-175. (VUmc)

1663. van der Esch M, Knoop J, van der Leeden M, Voorneman R, Gerritsen M, Reiding D, Romviel S, Knol DL, Lems WF, Dekker J, Roorda LD. Self-reported knee instability and activity limitations in patients with knee osteoarthritis: results of the Amsterdam osteoarthritis cohort. Clinical Rheumatology 2012; 31: 1505-1510. (VUmc)

1664. van der Gaag NA, Kloek JJ, de Bakker JK, Musters B, Geskus RB, Busch ORC, Bosma A, Gouma DJ, van Gulik TM. Survival analysis and prognostic nomogram for patients undergoing resection of extrahepatic cholangiocarcinoma. Annals Of Oncology 2012; 23(10): 2642-2649. (AMC)

1665. van der Gaag NA, van Gulik TM, Busch ORC, Sprangers MA, Bruno MJ, Zevenbergen C, Gouma DJ, Boermeester MA. Functional and medical outcomes after tailored surgery for pain due to chronic pancreatitis. Annals Of Surgery 2012; 255(4): 763-770. (AMC)

1666. Van der Heide UA, Houweling AC, Groenendaal G, Beets-Tan RG, Lambin P. Functional MRI for radiotherapy dose painting. Magn Reson Imaging 2012; 30: 1216-23 (NKI)

1667. Van der Heiden-van der Loo M, de Munck L, Visser O, Westenend PJ, van Dalen T, Menke MB, Rutgers EJT, Peeters PH. Variation between hospitals in surgical margins after first breast-conserving surgery in the Netherlands. Breast Cancer Res Treat 2012; 131: 691-8 (NKI)

1668. van der Helm JJ, Sabajo LOA, Grunberg AW, Morre SA, Speksnijder AGCL, de Vries HJC. Point-of-Care Test for Detection of Urogenital Chlamydia in Women Shows Low Sensitivity. A Performance Evaluation Study in Two Clinics in Suriname. PloS one 2012; 7: . (VUmc)

1669. van der Horst-Bruinsma I, Nurmohamed MT, Landewe RBM. Comorbidities in Patients with Spondyloarthritis. Rheumatic Disease Clinics of North America 2012; 38: 523-+. (VUmc)

1670. van der Horst-Bruinsma I, Nurmohamed MT. Management and evaluation of extra-articular manifestations in spondyloarthritis. Therapeutic Advances in Musculoskeletal Disease 2012; 4: 413-422. (VUmc)

1671. Van der Kaaij M, Heutte N, Meijnders P, Abeilard-Lemoisson E, Spina M, Moser EC, Allgeier A, Meulemans B, Simons AH, Lugtenburg PJ, Aleman BM, Noordijk EM, Fermé C, Thomas J, Stamatoullas A, Fruchart C, Brice P, Gaillard I, Bologna S, Ong F, Eghbali H, Doorduijn JK, Morschhauser F, Sebban C, Roesink JM, Bouteloup M, Van Hoof A, Raemaekers JM, Henry-Amar M, Kluin-Nelemans HC. Premature ovarian failure and fertility in longterm organisation for research and treatment of Cancer Lymphoma Group and Groupe d’Etude des Lymphomes de lAdulte Cohort Study. J Clin Oncol 2012; 30: 291-9 (NKI)

1672. Van der Kaaij MA, Heutte N, Meijnders P, Abeilard-Lemoisson E, Spina M, Moser LC, Allgeier A, Meulemans B, Dubois B, Simons AH, Lugtenburg PJ, Aleman BM, Noordijk EM, Fermé C, Thomas J, Stamatoullas A, Fruchart C, Brice P, Gaillard I, Doorduijn JK, Sebban C, Smit WG, Bologna S, Roesink JM, Ong F, André MP, Raemaekers JM, Henry-Amar M, Kluin-Nelemans HC. Parenthood in survivors of Hodgkin lymphoma; an EORTC-GELA general population case-control study. J Clin Oncol 2012; 30: 3854-63 (NKI)

1673. van der Kolk JH, van Putten LA, Mulder CJ, Grinwis GCM, Reijm M, Butler CM, von Blomberg BME. Gluten-dependent antibodies in horses with inflammatory small bowel disease (ISBD). Veterinary Quarterly 2012; 32: 3-11. (VUmc)

1674. van der Kwast T, Al Daoud N, Collette L, Sykes J, Thoms J, Milosevic M, Bristow RG, van Tienhoven G, Warde P, Mirimanoff RO, Bolla M. Biopsy diagnosis of intraductal carcinoma is prognostic in intermediate and high risk prostate cancer patients treated by radiotherapy. European Journal Of Cancer 2012; 48(9): 1318-1325. (AMC)

1675. van der Kwast T, Al Daoud N, Collette L, Sykes J, Thoms J, Milosevic M, Bristow RG, van Tienhoven G, Warde P, Mirimanoff RO, Bolla M. Biopsy diagnosis of intraductal carcinoma is prognostic in intermediate and high risk prostate cancer patients treated by radiotherapy (vol 48, pg 1318, 2012). European Journal Of Cancer 2012; 48(14): 2292-. (AMC)

1676. van der Laan AM, Hirsch A, Robbers LFHJ, Nijveldt R, Lommerse I, Delewi R, van der Vleuten PA, Biemond BJ, Zwaginga JJ, van der Giessen WJ, Zijlstra F, van Rossum AC, Voermans C, van der Schoot CE, Piek JJ. A proinflammatory monocyte response is associated with myocardial injury and impaired functional outcome in patients with ST-segment elevation myocardial infarction: monocytes and myocardial infarction. American Heart Journal 2012; 163(1): 57-65.e2. (AMC)

1677. van der Laan AM, Schirmer SH, de Vries MR, Koning JJ, Volger OL, Fledderus JO, Bastiaansen AJNM, Hollander MR, Baggen JM, Koch KT, Baan J, Henriques JP, van der Schaaf RJ, Vis MM, Mebius RE, Kraan TCV, Quax PH, Piek JJ, Horrevoets AJ, van Royen N. Galectin-2 expression is dependent on the rs7291467 polymorphism and acts as an inhibitor of arteriogenesis. European Heart Journal 2012; 33: 1076-1084. (VUmc)

1678. van der Laken CJ, Huisman MH, Voskuyl AE. Nuclear imaging of rheumatic diseases. Best Pract Res Clin Rheumatol 2012; 26: 787-804. (VUmc)

1679. van der Leest C, Smit E, Baas J, Versteijlen R, van Walree N, Hoogsteden H, Aerts J. SUVmax during 18FDG-PET scanning in small cell lung cancer: Similar information as in non-small cell lung cancer?. Lung Cancer 2012; 76: 67-71. (VUmc)


1680. van der Leest RJT, Liu L, Coebergh JWW, Neumann HAM, Mooi WJ, Nijsten T, de Vries E. Risk of second primary in situ and invasive melanoma in a Dutch population-based cohort: 1989-2008. British Journal of Dermatology 2012; 167: 1321-1330. (VUmc)

1681. Van der Leij F, Elkhuizen PH, Bartelink H, van de Vijver MJ. Predictive factors for local recurrence in breast cancer. Semin Radiat Oncol 2012; 22: 100-7 (NKI/AMC)

1682. van der Meij B, Langius J, Spreeuwenberg M, Slootmaker S, Paul M, Smit E, van Leeuwen P. Oral nutritional supplements containing n-3 polyunsaturated fatty acids affect quality of life and functional status in lung cancer patients during multimodality treatment: an RCT. European Journal of Clinical Nutrition 2012; 66: 399-404. (VUmc)

1683. van der Molen L, van Rossum MA, Jacobi I, van Son RJJH, Smeele LE, Rasch CRN, Hilgers FJM. Pre- and Posttreatment Voice and Speech Outcomes in Patients With Advanced Head and Neck Cancer Treated With Chemoradiotherapy: Expert Listeners' and Patient's Perception. Journal Of Voice 2012; 26(5): 664.e25-664.e33. (AMC/NKI)

1684. Van der Pal H, van Dalen E, van Delden E, van Dijk I, Kok W, Geskus R, Sieswerda E, Oldenburger F, Koning C, van Leeuwen F, Caron H, Kremer L. High Risk of Symptomatic Cardiac Events in Childhood Cancer Survivors. Journal of Clinical Oncology 2012; 30: 1429-1437 (NKI/AMC)

1685. Van der Ploeg APT, Van Akkooi ACJ, Rutkowski P, Cook M, Nieweg OE, Rossi CR, Testori A, Verhoef C, Eggermont AMM; European Organization for Research and Treatment of Cancer Melanoma Group. Prognosis in patients with sentinel node positive without immediate completion lymph node dissection. Br J Surg 2012; 99: 1396- 1405 (NKI)

1686. van der Pluijm RW, Lamers MJ, de Boer M, van der Graaf WTA, van Laarhoven HWM. A female with a leiomyosarcoma presenting with acute thoracic pain and dyspnoea. Netherlands Journal Of Medicine 2012; 70(8): 377-. (AMC)

1687. Van der Poel HG, Balm AJ, Nieweg OE, Valdes Olmos RA. Comment on Heuveling et al.: Nanocolloidal albumin-IRDye 800CW: a near-infrared fluorescent tracer with optimal retention in the sentinel lymph node. European journal of nuclear medicine and molecular imaging 2012; 39: 1510-1 (NKI)

1688. Van der Poel HG, Brouwer OR, van den Berg NS, Buckle T, van Leeuwen FWB. Reply to Karol Polom, Dawid Murawa, Wojciech polom’s letter to the editor re: Henk G. van der Poel, Tessa Buckle, Oscar R. Brouwer, Renato A. Valdes Olmos, Fijs W.B. van Leeuwen. Intraoperative laparoscopic fluorescence guidance to the sentinel lymph node in prostate cancer patients: Clinical proof of concept of an integrated functional imaging approach using a multimodal tracer. Eur Urol 2012; 61: e19-e20 (NKI)

1689. Van der Poel HG, de Blok W, Tillier C, van Muilekom E. Robot-assisted laparoscopic prostatectomy: nodal dissection results during the first 440 cases by two surgeons. J Endourol 2012; 26: 1618-24 (NKI)

1690. Van der Poel HG, Tillier C, de Blok W, van Muilekom E. Extended nodal dissection reduces sexual function recovery after robot-assisted laparoscopic prostatectomy. J Endourol 2012; 26: 1192-8 (NKI)

1691. Van der Poel HG. Words of wisdom: Re: Super extended versus extended pelvic lymph node dissection in patients undergoing radical cystectomy for bladder cancer: a comparative study. Eur Urol 2012; 61: 1266-7 (NKI)

1692. van der Pol E, Böing AN, Harrison P, Sturk A, Nieuwland R. Classification, functions, and clinical relevance of extracellular vesicles. Pharmacological Reviews 2012; 64(3): 676-705. (AMC)

1693. van der Pol E, van Gemert MJC, Sturk A, Nieuwland R, van Leeuwen TG. Single vs. swarm detection of microparticles and exosomes by flow cytometry. Journal Of Thrombosis And Haemostasis 2012; 10(5): 919-930. (AMC)

1694. van der Pouw Kraan T, Baggen JM, van Bodegraven AA, Mulder CJJ, Zwiers A, Geerts D, Kraal G, Horrevoets AJG, Bouma G. Defective IL-1A expression in patients with Crohn's disease is related to attenuated MAP3K4 signaling. Human Immunology 2012; 73: 912-919. (VUmc)

1695. van der Putten L, Spasiano R, de Bree R, Bertino G, Leemans CR, Benazzo M. Flap reconstruction of the hypopharynx: a defect orientated approach. Acta Otorhinolaryngol Ital 2012; 32: 288-296. (VUmc)

1696. van der Sluijs Veer L, Kempers MJE, Wiedijk BM, Last BF, Grootenhuis MA, Vulsma T. Evaluation of cognitive and motor development in toddlers with congenital hypothyroidism diagnosed by neonatal screening. Journal Of Developmental And Behavioral Pediatrics 2012; 33(8): 633-640. (AMC)

1697. van der Sluis TM, Bui HN, Meuleman EJH, Heijboer AC, Hartman JF, van Adrichem N, Boeve E, de Ronde W, van Moorselaar RJA, Vis AN. Lower Testosterone Levels With Luteinizing Hormone-Releasing Hormone Agonist Therapy Than With Surgical Castration: New Insights Attained by Mass Spectrometry. Journal of Urology 2012; 187: 1601-1606. (VUmc)

1698. van der Sluis TM, Vis AN, van Moorselaar RJA, Bui HN, Blankenstein MA, Meuleman EJH, Heijboer AC. Intraprostatic testosterone and dihydrotestosterone. Part I: concentrations and methods of determination in men with benign prostatic hyperplasia and prostate cancer. BJU International 2012; 109: 176-182. (VUmc)

1699. van der Spek BW, Cuesta MA, Jacobs MA. A patient with biliary colic and intestinal obstruction. Gut 2012; 61: 713-752. (VUmc)

1700. Van der Steen LP, Bakema JE, Sesarman A, Florea F, Tuk CW, Kirtschig G, Hage JJ, Sitaru C, van Egmond M. Blocking FC��receptor I on granulocytes prevents tissue damage induced by IgA autoantbodies. J Immunol 2012; 189: 1594-601 (VUmc/NKI)

1701. van der Veen BJ, Al Younis I, Ajmone- Marsan N, Westenberg JJ, Bax JJ, Stokkel MP, de Roos A. Ventricular dyssynchrony assessed by gated myocardial perfusion SPECT using a geometrical approach: a feasibility study. Eur J Nucl Med Mol Imaging 2012; 39: 421-9 (NKI)

1702. Van der Veen BJ, Al Younis I, de Roos A, Stokkel MP. Assessment of global cardiac I-123 MIBG uptake and washout using volumetric quantification of SPECT acquisitions. J Nucl Cardiol 2012; 19: 752-62 (NKI)

1703. van der Velden J, Fons G. Regarding "reasons for diagnostic delay in gynecological malignancies". International Journal Of Gynecological Cancer 2012; 22(3): 342-. (AMC)

1704. Van der Veldt AA, Lammertsma AA, Smit EF. Scheduling of anticancer drugs Timing may be everything. Cell Cycle 2012; 11: 4339-4343. (VUmc)

1705. Van der Veldt AA, Smit EF. Bevacizumab in Neoadjuvant Treatment for Breast Cancer. New England Journal of Medicine 2012; 366: 1637. (VUmc)

1706. Van der Veldt AAM, Lubberink M, Bahce I, Walraven M, de Boer MP, Greuter HNJM, Hendrikse NH, Eriksson J, Windhorst AD, Postmus PE, Verheul HM, Serne EH, Lammertsma AA, Smit EF. Rapid Decrease in Delivery of Chemotherapy to Tumors after Anti-VEGF Therapy: Implications for Scheduling of Anti-Angiogenic Drugs. Cancer Cell 2012; 21: 82-91. (VUmc)

1707. Van der Veldt AAM, Vroling L, de Haas RR, Koolwijk P, van den Eertwegh AJM, Haanen JBAG, van Hinsbergh VWM, Broxterman HJ, Boven E. Sunitinib-induced changes in circulating endothelial cell-related proteins in patients with metastatic renal cell cancer. International Journal of Cancer 2012; 131: E484-E493. (NKI/VUmc)


1708. van der Vlies CH, Hoekstra J, Ponsen KJ, Reekers JA, van Delden OM, Goslings JC. Impact of splenic artery embolization on the success rate of nonoperative management for blunt splenic injury. Cardiovascular And Interventional Radiology 2012; 35(1): 76-81. (AMC)

1709. van der Vlies CH, Olthof DC, van Delden OM, Ponsen KJ, de la Rosette JJMCH, de Reijke TM, Goslings JC. Management of blunt renal injury in a level 1 trauma centre in view of the European guidelines. Injury-International Journal Of The Care Of The Injured 2012; 43(11): 1816-1820. (AMC)

1710. van der Vlies CH, Saltzherr TP, Reekers JA, Ponsen KJ, van Delden OM, Goslings JC. Failure rate and complications of angiography and embolization for abdominal and pelvic trauma. Journal Of Trauma And Acute Care Surgery 2012; 73(5): 1208-1212. (AMC)

1711. Van der Vliet HJ, Verheul HM. Breast-Cancer Adjuvant Therapy with Zoledronic Acid. New England Journal of Medicine 2012; 366: 188-189. (VUmc)

1712. van der Waal MS, Saurin AT, Vromans MJ, Vleugel M, Wurzenberger C, Gerlich DW, Medema RH, Kops GJ, Lens SM. Mps1 promotes rapid centromere accumulation of Aurora B. EMBO Rep 2012; 13: 847-54 (NKI)

1713. van der Weijden MAC, Claushuis TAM, Nazari T, Lems WF, Dijkmans BAC, van der Horst-Bruinsma I. High prevalence of low bone mineral density in patients within 10 years of onset of ankylosing spondylitis: a systematic review. Clinical Rheumatology 2012; 31: 1529-1535. (VUmc)

1714. van der Weijden MAC, van der Horst-Bruinsma I, van Denderen JC, Dijkmans BAC, Heymans MW, Lems WF. High frequency of vertebral fractures in early spondylarthropathies. Osteoporosis International 2012; 23: 1683-1690. (VUmc)

1715. van der Woude AD, Sarkar D, Bhatt A, Sparrius M, Raadsen SA, Boon L, Geurtsen J, van der Sar AM, Luirink J, Houben ENG, Besra GS, Bitter W. Unexpected Link between Lipooligosaccharide Biosynthesis and Surface Protein Release in Mycobacterium marinum. Journal of Biological Chemistry 2012; 287: 20417-20429. (VUmc)

1716. van der Woude D, Visser K, Klarenbeek NB, Ronday HK, Peeters AJ, Kerstens PJSM, Dijkmans BAC, Huizinga TWJ, van der Helm-van Mil A, Allaart CF. Sustained drug-free remission in rheumatoid arthritis after DAS-driven or non-DAS-driven therapy: a comparison of two cohort studies. Rheumatology 2012; 51: 1120-1128. (VUmc)

1717. van der Zouwen B, Kruisselbrink AB, Jordanova ES, Rutten CE, Borne PA, Falkenburg J, Jedema I. Alloreactive Effector T Cells Require the Local Formation of a Proinflammatory Environment to Allow Crosstalk and High Avidity Interaction with Nonhematopoietic Tissues to Induce GVHD Reactivity. Biology of Blood and Marrow Transplantation 2012; 18: 1353-1367. (VUmc)

1718. van Dijk A, Naaijkens BA, Jurgens WJFM, Oerlemans R, Scheffer GL, Kassies J, Aznou J, Brouwer M, van Rossum AC, Schuurhuis GJ, van Milligen FJ, Niessen HWM. The multidrug resistance protein breast cancer resistance protein (BCRP) protects adipose-derived stem cells against ischemic damage. Cell Biology and Toxicology 2012; 28: 303-315. (VUmc)

1719. van Dijk FS, Cobben JM, Maugeri A, Nikkels PGJ, van Rijn RR, Pals G. Osteogenesis imperfecta: klinische en genetische heterogeniteit. Nederlands Tijdschrift Voor Geneeskunde 2012; 156(21): A4585-. (AMC)

1720. van Dijk HW, Verbraak FD, Kok PHB, Stehouwer M, Garvin MK, Sonka M, DeVries JH, Schlingemann RO, Abràmoff MD. Early Neurodegeneration in the Retina of Type 2 Diabetic Patients. Investigative Ophthalmology & Visual Science 2012; 53(6): 2715-2719. (AMC)

1721. Van Dijk I, Cardous-Ubbink M, van der Pal H, Heinen R, van Leeuwen F, Oldenburger F, van Os R, Ronckers CM, Schouten-van Meeteren A, Caron H, Koning C, Kremer L. Dose-Effect Relationships for Adverse Events After Cranial Radiation Therapy in Long-term Childhood Cancer Survivors. International Journal of Radiation Oncology*Biology*Physics (NKI)

1722. van Dongen GAMS, Poot AJ, Vugts DJ. PET imaging with radiolabeled antibodies and tyrosine kinase inhibitors: immuno-PET and TKI-PET. Tumor Biology 2012; 33: 607-615. (VUmc)

1723. van Doormaal FF, Kleinjan A, Berckmans RJ, Mackman N, Manly D, Kamphuisen PW, Richel DJ, Büller HR, Sturk A, Nieuwland R. Coagulation activation and microparticle-associated coagulant activity in cancer patients. An exploratory prospective study. Thrombosis And Haemostasis 2012; 108(1): 160-165. (AMC)

1724. van Doorn SC, Dekker E. Colonoscopy quality begins with a clean colon. Endoscopy 2012; 44(7): 639-640. (AMC) 1725. van Drooge AM, Beek JF, van der Veen JPW, van der Horst CMAM, Wolkerstorfer A. Hypertrophy in port-wine stains:

prevalence and patient characteristics in a large patient cohort. Journal Of The American Academy Of Dermatology 2012; 67(6): 1214-1219. (AMC)

1726. van Drooge AM, Bosveld B, van der Veen JPW, de Rie MA, Wolkerstorfer A. Long-pulsed 1064 nm Nd:YAG laser improves hypertrophic port-wine stains. Journal Of The European Academy Of Dermatology And Venereology 2012. (AMC)

1727. van Eijk IC, Nielen MMJ, van der Horst-Bruinsma I, Tijhuis GJ, Boers M, Dijkmans BAC, van Schaardenburg D. Aggressive therapy in patients with early arthritis results in similar outcome compared with conventional care: the STREAM randomized trial. Rheumatology 2012; 51: 686-694. (VUmc)

1728. Van Elmpt W, De Ruysscher D, van der Salm A, Lakeman A, van der Stoep J, Emans D, Damen E, Ollers M, Sonke JJ, Belderbos J.The PET-boost randomised phase II dose-escalation trial in nonsmall cell lung cancer. Radiother Oncol 2012; 104: 67-71 (NKI)

1729. van Elsland SL, Springer P, Steenhuis IHM, van Toorn R, Schoeman JF, van Furth AM. Tuberculous Meningitis: Barriers to Adherence in Home Treatment of Children and Caretaker Perceptions. Journal of Tropical Pediatrics 2012; 58: 275-279. (VUmc)

1730. van Empel PJ, Van der Veer WM, van Rijssen LB, Cuesta MA, Scheele F, Bonjer HJ, Meijerink WJ. Mapping the Maze of Minimally Invasive Surgery Simulators. Journal of Laparoendoscopic & Advanced Surgical Techniques 2012; 22: 51-60. (VUmc)

1731. van Engen-Verheul M, Peute L, Kilsdonk E, Peek N, Jaspers M. Usability evaluation of a guideline implementation system for cardiac rehabilitation: think aloud study. Studies In Health Technology And Informatics 2012; 180: 403-407. (AMC)

1732. van Es J, Mos I, Douma R, Erkens P, Durian M, Nizet T, van Houten A, Hofstee H, ten Cate H, Ullmann E, Buller H, Huisman M, Kamphuisen PW. The combination of four different clinical decision rules and an age-adjusted D-dimer cut-off increases the number of patients in whom acute pulmonary embolism can safely be excluded. Thrombosis and Haemostasis 2012; 107: 167-171. (VUmc)


1733. van Esch EM, Welters MJ, Jordanova ES, Trimbos J, van der Burg SH, van Poelgeest MI. Treatment failure in patients with HPV 16-induced vulvar intraepithelial neoplasia: understanding different clinical responses to immunotherapy. Expert Review of Vaccines 2012; 11: 821-840. (VUmc)

1734. van Essen HF, Ylstra B. High-resolution copy number profiling by array CGH using DNA isolated from formalin-fixed, paraffin-embedded tissues. Methods in Molecular Biology 2012; 838: 329-341. (VUmc)

1735. Van Geel RM, Beijnen JH, Schellens JH. Concise drug review: pazopanib and axitinib. Oncologist 2012; 17: 1081-9 (NKI)

1736. van Geenen EM, Sachar DB. Infliximab in Crohn's Disease-associated Toxic Megacolon. Journal of Clinical Gastroenterology 2012; 46: 321-323. (VUmc)

1737. van Geest RJ, Lesnik-Oberstein SY, Tan HS, Mura M, Goldschmeding R, van Noorden CJF, Klaassen I, Schlingemann RO. A shift in the balance of vascular endothelial growth factor and connective tissue growth factor by bevacizumab causes the angiofibrotic switch in proliferative diabetic retinopathy. British Journal Of Ophthalmology 2012; 96(4): 587-590. (AMC)

1738. van Gils CWM, Koopman M, Mol L, Redekop WK, Uyl-de Groot CA, Punt CJA. Adjuvant chemotherapy in stage III colon cancer: guideline implementation, patterns of use and outcomes in daily practice in The Netherlands. Acta Oncologica 2012; 51(1): 57-64. (AMC)

1739. van Gils RF, Boot CRL, Knol DL, Rustemeyer T, van Mechelen W, van der Valk PGM, Anema JR. The effectiveness of integrated care for patients with hand eczema: results of a randomized, controlled trial. Contact Dermatitis 2012; 66: 197-204. (VUmc)

1740. van Gils RF, Groenewoud K, Boot CRL, Rustemeyer T, van Mechelen W, van der Valk PGM, Anema JR. Process evaluation of an integrated, multidisciplinary intervention programme for hand eczema. Contact Dermatitis 2012; 66: 254-263. (VUmc)

1741. van Gisbergen KPJM, Kragten NAM, Hertoghs KML, Wensveen FM, Jonjic S, Hamann J, Nolte MA, van Gogh CDL, Verdonck-de Leeuw IM, Langendijk JA, Kuik DJ, Mahieu HF. Long-Term Efficacy of Voice Therapy in Patients With Voice Problems After Treatment of Early Glottic Cancer. Journal of Voice 2012; 26: 398-401. (VUmc)

1742. van Gogh CDL, Verdonck-de Leeuw IM, Wedler-Peeters J, Langendijk JA, Mahieu HF. Prospective evaluation of voice outcome during the first two years in male patients treated by radiotherapy or laser surgery for T1a glottic carcinoma. European Archives of Oto-Rhino-Laryngology 2012; 269: 1647-1652. (VUmc)

1743. van Golen RF, van Gulik TM, Heger M. Mechanistic overview of reactive species-induced degradation of the endothelial glycocalyx during hepatic ischemia/reperfusion injury. Free Radical Biology And Medicine 2012; 52(8): 1382-1402. (AMC)

1744. van Golen RF, van Gulik TM, Heger Michal. The sterile immune response during hepatic ischemia/reperfusion. Cytokine & Growth Factor Reviews 2012; 23(3): 69-84. (AMC)

1745. van Hagen P, Hulshof MCCM, van Lanschot JJB, Steyerberg EW, van Berge Henegouwen MI, Wijnhoven BPL, Richel DJ, Nieuwenhuijzen GAP, Hospers GAP, Bonenkamp JJ, Cuesta MA, Blaisse RJB, Busch ORC, ten Kate FJW, Creemers GJ, Punt CJA, Plukker JTM, Verheul HMW, Spillenaar Bilgen EJ, van Dekken H, van der Sangen MJC, Rozema T, Biermann K, Beukema JC, Piet AHM, van Rij CM, Reinders JG, Tilanus HW, van der Gaast A. Preoperative Chemoradiotherapy for Esophageal or Junctional Cancer. New England Journal Of Medicine 2012; 366(22): 2074-2084. (AMC/VUmc)

1746. Van Hasselt JG, Schellens JH, Mac Gillavry MR, Beijnen JH, Huitema AD. Model-based evaluation and optimization of cardiac monitoring protocols for adjuvant treatment of breast cancer with trastuzumab. Pharm Res 2012; 29: 3499-511 (NKI)

1747. Van Hasselt JG, van den Heuvel MM, Schellens JH, Beijnen JH, Brandsma D, Huitema AD. Severe cannabinoid intoxication in a patient with nonsmall- cell lung cancer. J Palliat Care 2012; 28: 60-1 (NKI)

1748. Van Heel NC, Haringsma J, Boot H, Cats A, Vanhoutvin SA, Kuipers EJ. Comparison of 2 expandable stents for malignant esophageal disease: a randomized controlled trial. Gastrointest Endosc 2012; 76: 52-8 (NKI)

1749. Van Herk-Sukel MP, Shantakumar S, Overbeek LI, van Boven H, Penning-van Beest FJ, Herings RM. Occurrence of Comorbidities before and after Soft Tissue Sarcoma Diagnosis. Sarcoma 2012; 2012 (NKI)

1750. van Heumen BWH, Nieuwenhuis MH, van Goor H, Mathus-Vliegen LEMH, Dekker E, Gouma DJ, Dees J, van Eijck CHJ, Vasen HFA, Nagengast FM. Surgical management for advanced duodenal adenomatosis and duodenal cancer in Dutch patients with familial adenomatous polyposis: a nationwide retrospective cohort study. Surgery 2012; 151(5): 681-690. (AMC)

1751. Van Hooff SR, Leusink FKJ, Roepman P, Baatenburg de Jong RJ, Speel EJM, Van den Brekel MWM, Van Velthuysen MLF, Van Diest PJ, Van Es RJJ, Merkx MAW, Kummer JA, Leemans CR, Schuuring E, Langendijk JA, Lacko M, De Herdt MJ, Jansen JC, Brakenhoff RH, Slootweg PJ, Takes RP, Holstege FCP. Validation of a gene expression signature of assessment of lymph node metastasis in oral squamous cell carcinoma. J Clin Oncol 2012; 30: 4104-10 (NKI)

1752. van Hooff SR, Leusink FKJ, Roepman P, de Jong RJB, Speel EJM, van den Brekel MWM, van Velthuysen MLF, van Diest PJ, Van Es RJJ, Merkx MAW, Kummer JA, Leemans CR, Schuuring E, Langendijk JA, Lacko M, De Herdt MJ, Jansen JC, Brakenhoff RH, Slootweg PJ, Takes RP, Holstege FCP. Validation of a Gene Expression Signature for Assessment of Lymph Node Metastasis in Oral Squamous Cell Carcinoma. J Clin Oncol 2012; 30: 4104-4110. (VUmc)

1753. van Hoorn T, Paul P, Janssen L, Janssen H, Neefjes J. Dynamics within tetraspanin pairs affect MHC class II expression. J Cell Sci 2012; 125: 328-39 (NKI)

1754. van Houdt JKJ, Nowakowska BA, Sousa SB, van Schaik BDC, Seuntjens E, Avonce N, Sifrim A, Abdul-Rahman OA, van den Boogaard MH, Bottani A, Castori M, Cormier-Daire V, Deardorff MA, Filges I, Fryer A, Fryns J, Gana S, Garavelli L, Gillessen-Kaesbach G, Hall BD, Horn D, Huylebroeck D, Klapecki J, Krajewska-Walasek M, Kuechler A, Lines MA, Maas S, Macdermot KD, McKee S, Magee A, de Man SA, Moreau Y, Morice-Picard F, Obersztyn E, Pilch J, Rosser E, Shannon N, Stolte-Dijkstra I, van Dijck P, Vilain C, Vogels A, Wakeling E, Wieczorek D, Wilson L, Zuffardi O, van Kampen AHC, Devriendt K, Hennekam R, Vermeesch JR. Heterozygous missense mutations in SMARCA2 cause Nicolaides-Baraitser syndrome. Nature Genetics 2012; 44(4): 445-9, S1. (AMC)

1755. Van Hulsteijn LT, Corssmit EP, van der Hiel B, Smit JW, Stokkel MP. Is there a role for radioguided surgery with iodine-labeled metaiodobenzylguanidine in resection of neuroendocrine tumors? Clin Nucl Med 2012; 37: 1083-88 (NKI)

1756. Van Hulsteijn LT, van der Hiel B, Smit JW, Stokkel MP, Corssmit EP. Intraoperative detection of ganglioneuromas with 123I-MIBG. Clin Nucl Med 2012; 37: 768-771 (NKI)

1757. van Iterson M, Bezemer R, Heger M, Siegemund M, Ince C. Microcirculation follows macrocirculation in heart and gut in the acute phase of hemorrhagic shock and isovolemic autologous whole blood resuscitation in pigs. Transfusion 2012; 52(7): 1552-1559. (AMC)


1758. Van Kesteren Z, Belderbos J, van Herk M, Olszewska A, Lamers E, De Ruysscher D, Damen E, van Vliet-Vroegindeweij C. A practical technique to avoid the hippocampus in prophylactic cranial irradiation for lung cancer. Radiother Oncol 2012; 102: 225-7 (NKI)

1759. Van Kesteren Z, Janssen TM, Damen E, van Vliet-Vroegindeweij C. The dosimetric impact of leaf interdigitation and leaf width on VMAT treatment planning in Pinnacle: comparing Pareto fronts. Phys Med Biol 2012; 57: 2943-52 (NKI)

1760. Van Kooten H, de Jonge V, Schreuders E, Sint Nicolaas J, van Leerdam ME, Kuipers EJ, Veldhuyzen van Zanten SJ. Awareness of postpolypectomy surveillance guidelines: a nationwide survey of colonoscopists in Canada. Can J Gastroenterol 2012; 26: 79-84 (NKI)

1761. van Kuilenburg ABP, Dobritzsch D, Meijer J, Krumpel M, Selim LA, Rashed MS, Assmann B, Meinsma R, Lohkamp B, Ito T, Abeling NGGM, Saito K, Eto K, Smitka M, Engvall M, Zhang C, Xu W, Zoetekouw L, Hennekam RCM. ß-ureidopropionase deficiency: phenotype, genotype and protein structural consequences in 16 patients. Biochimica Et Biophysica Acta-Molecular Basis Of Disease 2012; 1822(7): 1096-1108. (AMC)

1762. van Kuilenburg ABP, Häusler P, Schalhorn A, Tanck MWT, Proost JH, Terborg C, Behnke D, Schwabe W, Jabschinsky K, Maring JG. Evaluation of 5-fluorouracil pharmacokinetics in cancer patients with a c.1905+1G>A mutation in DPYD by means of a Bayesian limited sampling strategy. Clinical Pharmacokinetics 2012; 51(3): 163-174. (AMC)

1763. van Laarhoven HWM, Schilderman J, Verhagen CAHHVM, Prins JB. Comparison of Attitudes of Guilt and Forgiveness in Cancer Patients Without Evidence of Disease and Advanced Cancer Patients in a Palliative Care Setting. Cancer Nursing 2012; 35(6): 483-492. (AMC)

1764. van Laethem JL, Verslype C, Iovanna JL, Michl P, Conroy T, Louvet C, Hammel P, Mitry E, Ducreux M, Maraculla T, Uhl W, van Tienhoven G, Bachet JB, Maréchal R, Hendlisz A, Bali M, Demetter P, Ulrich F, Aust D, Luttges J, Peeters M, Mauer M, Roth A, Neoptolemos JP, Lutz M. New strategies and designs in pancreatic cancer research: consensus guidelines report from a European expert panel. Annals Of Oncology 2012; 23(3): 570-576. (AMC)

1765. van Lammeren-Venema D, Regelink JC, Riphagen II, Zweegman S, Hoekstra OS, Zijlstra JM. 18F-fluoro-deoxyglucose positron emission tomography in assessment of myeloma-related bone disease: A systematic review. Cancer 2012; 118: 1971-1981. (VUmc)

1766. Van Leeuwen F, Frederiks F, Terweij M, De Vos D, Bakker BM. News About Old Histones - A Role for Histone Age in Controlling the Epigenome. Cell Cycle 2012; 11: 11-12 (NKI)

1767. Van Leeuwen WA, Schellens JH, Becker HE, de Haan L, van Westrhenen R. The subclinical course of a paracetamol intoxication: pitfall for patient and clinician. Tijdschr Psychiatr 2012; 54: 555-9 (NKI)

1768. van Lent PLEM, Blom AB, Schelbergen RFP, Sloetjes A, Lafeber FPJG, Lems WF, Cats H, Vogl T, Roth J, van den Berg WB. Active involvement of alarmins S100A8 and S100A9 in the regulation of synovial activation and joint destruction during mouse and human osteoarthritis. Arthritis and Rheumatism 2012; 64: 1466-1476. (VUmc)

1769. Van Lent W, Deetman JW, Teertstra HJ, Muller SH, Hans EW, van Harten WH. Reducing the throughput time of the diagnostic track involving CT scanning with computer simulation. Eur J Radiol. 2012 (NKI)

1770. Van Lent WAM, Deetman JW, Teertstra HJ, Muller SH, Hans EW, Van Harten WH. Reducing the throughput time of the diagnostic track involving CT scanning with computer simulation. Eur J Radiol 2012; 81: 3131-40 (NKI)

1771. van Liempt SWJD, van Rheenen-Flach LE, van Waesberghe JHTM, Bleeker MCG, Piek JMJ, Lambalk CB. Solely inhibin B producing ovarian tumour as a cause of secondary amenorrhoea with hot flushes: case report and review of literature. Human Reproduction 2012; 27: 1144-1148. (VUmc)

1772. van Lienden KP, van den Esschert JW, Rietkerk M, Heger M, Roelofs JJTH, Lameris JS, van Gulik TM. Short-term effects of combined hepatic vein embolization and portal vein embolization for the induction of liver regeneration in a rabbit model. Journal Of Vascular And Interventional Radiology 2012; 23(7): 962-967. (AMC)

1773. van Lier Margot GF, Wagner A, Biermann K, Mathus-Vliegen EMH, Kuipers EJ, van Leerdam ME. High cancer risk and increased mortality in patients with Peutz-Jeghers syndrome response. GUT 2012; 61(2): 322-323. (AMC)

1774. Van Lier MG, Korsse SE, Mathus- Vliegen EM, Kuipers EJ, van den Ouweland AM, Vanheusden K, van Leerdam ME, Wagner A. Peutz-Jeghers syndrome and family planning: the attitude towards prenatal diagnosis and pre-implantation genetic diagnosis. Eur J Hum Genet 2012; 20: 236-9 (NKI/AMC)

1775. van Lier RAW. Mouse Hobit is a homolog of the transcriptional repressor Blimp-1 that regulates NKT cell effector differentiation. Nature Immunology 2012; 13(9): 864-871. (AMC)

1776. Van Lonkhuijzen L, Stekelenburg J, van Roosmalen J. Maternity waiting facilities for improving maternal and neonatal outcome in low-resource countries. Cochrane Database Syst Rev 2012; 10: CD006759 (NKI)

1777. Van Loon J, Siedschlag C, Stroom J, Blauwgeers H, van Suylen RJ, Knegjens J, Rossi M, van Baardwijk A, Boersma L, Klomp H, Vogel W, Burgers S, Gilhuijs K. Microscopic disease extension in three dimensions for nonsmall- cell-lung cancer: development of a prediction model using pathologyvalidated positron emission tomography and computed tomography features. Int J Radiat Oncol Biol Phys 2012; 82: 448-56 (NKI)

1778. Van Luenen HG, Farris C, Jan S, Genest PA, Tripathi P, Velds A, Kerkhoven RM, Nieuwland M, Haydock A, Ramasamy G, Vainio S, Heidebrecht T, Perrakis A, Pagie L, van Steensel B, Myler PJ, Borst P. Glucosylated hydroxymethyluracil, DNA base j, prevents transcriptional readthrough in leishmania. Cell 2012; 150: 909-21 (NKI/AMC)

1779. van Luijn MM, Chamuleau MED, Ossenkoppele GJ, van de Loosdrecht AA, van Ham SM. Tumor immune escape in acute myeloid leukemia: Class II-associated invariant chain peptide expression as result of deficient antigen presentation.. Oncoimmunology 2012; 1: 211-213. (VUmc)

1780. van Luijn MM, de Loosdrecht AAV, Lampen MH, van Veelen PA, Zevenbergen A, Kester MGD, De Ru AH, Ossenkoppele GJ, van Hall T, van Ham SM. Promiscuous Binding of Invariant Chain-Derived CLIP Peptide to Distinct HLA-I Molecules Revealed in Leukemic Cells. PloS one 2012; 7: . (VUmc)

1781. van Maldegem F, Wormhoudt TAM, Mulder MMS, Oud MECM, Schilder-Tol E, Musler AR, Aten J, Saeed P, Kersten MJ, Pals ST, van Noesel CJM, Bende RJ. Chlamydia psittaci-negative ocular adnexal marginal zone B-cell lymphomas have biased VH4-34 immunoglobulin gene expression and proliferate in a distinct inflammatory environment. Leukemia 2012; 26(7): 1647-1653. (AMC)

1782. Van Miltenburg MH, Jonkers J. Using genetically engineered mouse models to validate candidate cancer genes and test new therapeutic approaches. Curr Opin Genet Dev 2012; 22: 21-7 (NKI)

1783. Van Monsjou HS, Lopez-Yurda MI, Hauptmann M, Van den Brekel MW, Balm AJ, Wreesmann VB. Oral and oropharyngeal squamous cell carcinoma in young patients: The Netherlands Cancer Institute experience. Head Neck. 2013; 35: 94-102 (NKI)

1784. Van Monsjou HS, Van Velthuysen ML, Van den Brekel MWM, Jordanova ES, Melief CJ, Balm AJM. Human papillomavirus status in young patients with head and neck squamous cell carcinoma. Int J Cancer 2012; 130: 1806-12 (NKI/VUmc)


1785. Van Nifterik KA, Van den Berg J, Slotman BJ, Lafleur MVM, Sminia P, Stalpers LJA. Valproic acid sensitizes human glioma cells for temozolomide and gamma-radiation. Journal of Neuro-Oncology 2012; 107: 61-67. (AMC/VUmc)

1786. van Oers MHJ. CD20 antibodies: type II to tango? Blood 2012; 119(22): 5061-5063. (AMC) 1787. van Poppel H, Haese A, Graefen M, de la Taille A, Irani J, de Reijke T, Remzi M, Marberger M. The relationship

between Prostate CAncer gene 3 (PCA3) and prostate cancer significance. BJU International 2012; 109(3): 360-366. (AMC)

1788. van Pul KM, Vuylsteke RJCL, Bril H, Stockmann HBAC, de Gruijl TD. Feasibility of flowcytometric quantitation of immune effector cell subsets in the sentinel lymph node of the breast after cryopreservation. Journal of Immunological Methods 2012; 375: 189-195. (VUmc)

1789. Van Putten PG, Ter Borg F, Adang RP, Koornstra JJ, Romberg-Camps MJ, Timmer R, Poen AC, Kuipers EJ, Van Leerdam ME. Nurse endoscopists perform colonoscopies according to the international standard and with high patient satisfaction. Endoscopy 2012; 44: 1127-32 (NKI)

1790. van Raalte D, den Uyl D, Nurmohamed M, Diamant M, Lems W. Hyperglycemia and methylprednisolone: Comment on the article by den Uyl et al Reply. Arthritis and Rheumatism 2012; 64: 3823. (VUmc)

1791. Van Rhijn BD, Smout AJ, Bredenoord AJ. [Eosinophilic oesophagitis: a frequently missed cause of dysphagia]. Nederlands tijdschrift voor geneeskunde 2012; 156: A4716 (NKI)

1792. Van Rhijn BW, Liu L, Vis AN, Bostrom PJ, Zuiverloon TC, Fleshner NE, et al. Prognostic value of molecular markers, sub-stage and European Organisation for the Research and Treatment of Cancer risk scores in primary T1 bladder cancer. BJU Int 2012; 110: 1169-76 (NKI)

1793. Van Rhijn BW, van der Kwast TH, Liu L, Fleshner NE, Bostrom PJ, Vis AN, et al. The FGFR3 mutation is related to favorable pT1 bladder cancer. J Urol 2012; 187: 310-4 (NKI)

1794. Van Rhijn BW. Combining molecular and pathologic data to prognosticate non-muscle-invasive bladder cancer. Urologic oncology 2012; 3: 518-23 (NKI)

1795. Van Rhijn BW. Editorial comment. J Urol 2012; 187: 462 (NKI) 1796. Van Rhijn BWG, van der Kwast TH, Jewett MAS, Zlotta AR. Reply to Maximilian Burger, Wolfgang Otto, and Arndt

Hartmann’s letter to the editor re: Bas W.G. van Rhijn, Theo H. van der Kwast, Sultan S. Alkhateeb, et al. A new and highly prognostic system to discern T1 bladder cancer substage. Eur Urol 2012; 61: 378-84 (NKI)

1797. Van Rhijn BWG. Combining molecular and pathologic data to prognosticate non-muscle-invasive bladder cancer. Urologic Oncology: Seminars and Original Investigations 2012; 30: 518-23 (NKI)

1798. Van Rhijn BWG. Reply to Anna Orsola, Ines de Torres and Juan Morote’s Letter to the Editor re: Bas W.G. van Rhijn, Theo H. van der Kwast, Sultan S. Alkhateeb, et al. A New and Highly Prognostic System to Discern T1 Bladder Cancer Substage. Eur Urol 2012: 61: 378-84. Eur Urol 2012; 61: E55-E6 (NKI)

1799. van Riel S, Thunnissen E, Heideman D, Smit EF, Biesma B. A patient with simultaneously appearing adenocarcinoma and small-cell lung carcinoma harbouring an identical EGFR exon 19 mutation. Annals of Oncology 2012; 23: 3188-3189. (VUmc)

1800. van Rijen MML, Bode LGM, Baak DA, Kluytmans JAJW, Vos MC. Reduced Costs for Staphylococcus aureus Carriers Treated Prophylactically with Mupirocin and Chlorhexidine in Cardiothoracic and Orthopaedic Surgery. PloS one 2012; 7: . (VUmc)

1801. van Rijn AF, Stroobants AK, Deutekom M, Lauppe C, Sturk A, Bossuyt PMM, Fockens P, Dekker E. Inappropriate use of the faecal occult blood test in a university hospital in the Netherlands. EUROPEAN Journal Of Gastroenterology & Hepatology 2012; 24(11): 1266-1269. (AMC)

1802. van Rijn RR, Hobbs C, Bilo RAC. Response to 'A case for an in utero etiology of chronic SDH/effusions of infancy'. Journal Of Perinatology 2012; 32(1): 81-82. (AMC)

1803. van Rijn RR, Sieswerda-Hoogendoorn T. Educational paper: imaging child abuse: the bare bones. European Journal Of Pediatrics 2012; 171(2): 215-224. (AMC)

1804. van Rijssen LB, Brenninkmeijer EEA, Nieveen van Dijkum EJM. Secondary hyperparathyroidism: Uncommon cause of a leg ulcer. International Journal Of Surgery Case Reports 2012; 3(1): 30-33. (AMC)

1805. van Rooijen DC, van Wieringen N, Stippel G, Crezee J, Koning CCE, Bel A. Dose-guided radiotherapy: potential benefit of online dose recalculation for stereotactic lung irradiation in patients with non-small-cell lung cancer. International Journal Of Radiation Oncology Biology Physics 2012; 83(4): e557-e562. (AMC)

1806. Van Roon AH, Goede SL, van Ballegooijen M, van Vuuren AJ, Looman CW, Biermann K, Reijerink JC, Mannetje HT, van der Togt AC, Habbema JD, van Leerdam ME, Kuipers EJ. Random comparison of repeated faecal immunochemical testing at different intervals for population-based colorectal cancer screening. Gut. 2012 (NKI)

1807. Van Roon AH, Hol L, van Vuuren AJ, Francke J, Ouwendijk M, Heijens A, Nagtzaam N, Reijerink JC, van der Togt AC, van Ballegooijen M, Kuipers EJ, van Leerdam ME. Are fecal immunochemical test characteristics influenced by sample return time? A population-based colorectal cancer screening trial. Am J Gastroenterol 2012; 107: 99-107 (NKI)

1808. van Ruler O, Kiewiet JJS, van Ketel RJ, Boermeester MA. Initial microbial spectrum in severe secondary peritonitis and relevance for treatment. European Journal Of Clinical Microbiology & Infectious Diseases 2012; 31(5): 671-682. (AMC)

1809. van Santen HM, Tytgat GAM, van de Wetering MD, van Eck-Smit BLF, Hopman SMJ, van der Steeg AF, Nieveen van Dijkum EJM, van Trotsenburg ASP. Differentiated thyroid carcinoma after 131I-MIBG treatment for neuroblastoma during childhood: description of the first two cases. Thyroid 2012; 22(6): 643-646. (AMC)

1810. van Schaik FDM, Oldenburg B, Offerhaus GJA, Schipper MEI, Vleggaar FP, Siersema PD, van Oijen MGH, ten Kate FJW. Role of immunohistochemical markers in predicting progression of dysplasia to advanced neoplasia in patients with ulcerative colitis. Inflammatory Bowel Diseases 2012; 18(3): 480-488. (AMC)

1811. van Schoor G, den Heeten GJ, Broeders MJM, Verbeek ALM. Improving mammographic screening test sensitivity. Journal Of Medical Screening 2012; 19(2): 105-106. (AMC)

1812. van Schoor G, Otten JDM, den Heeten GJ, Holland R, Broeders MJM, Verbeek ALM. Breast cancer among women over 75 years: an important public health problem? European Journal Of Public Health 2012; 22(3): 422-424. (AMC)

1813. van Schuppen J, van Doorn MMAC, van Rijn RR. Childhood osteomyelitis: imaging characteristics. Insights Into Imaging 2012; 3(5): 519-533. (AMC)

1814. van Sijl AM, van den Hurk K, Peters MJL, Van Halm VP, Nijpels G, Stehouwer CDA, Smulders YM, Voskuyl AE, Dekker JM, Nurmohamed MT. Different Type of Carotid Arterial Wall Remodeling in Rheumatoid Arthritis Compared with Healthy Subjects: A Case-Control Study. Journal of Rheumatology 2012; 39: 2261-2266. (VUmc)


1815. van Sijl AM, van den Oever IAM, Peters MJL, Boers M, Dijkmans BAC, Van Halm VP, Smulders YM, Voskuyl AE, Nurmohamed MT. Subclinical renal dysfunction is independently associated with cardiovascular events in rheumatoid arthritis: the CARRE Study. Annals of the Rheumatic Diseases 2012; 71: 341-344. (VUmc)

1816. van Spaendonck-Zwarts KY, Badeloe S, Oosting SF, Hovenga S, Semmelink HJF, van Moorselaar RJA, van Waesberghe JH, Mensenkamp AR, Menko FH. Hereditary leiomyomatosis and renal cell cancer presenting as metastatic kidney cancer at 18 years of age: implications for surveillance. Familial Cancer 2012; 11: 123-129. (VUmc)

1817. van Steenwijk PJD, Ramwadhdoebe TH, Lowik MJG, van der Minne CE, Berends-van der Meer D, Fathers LM, Valentijn ARPM, Oostendorp J, Fleuren GJ, Hellebrekers BWJ, Welters MJP, van Poelgeest MI, Melief CJM, Kenter GG, van der Burg SH. A placebo-controlled randomized HPV16 synthetic long-peptide vaccination study in women with high-grade cervical squamous intraepithelial lesions. Cancer Immunology Immunotherapy 2012; 61: 1485-1492. (VUmc)

1818. van Tellingen A, Voskuyl AE, Vervloet MG, Bijl M, de Sevaux RGL, Berger SP, Derksen RHWM, Berden JHM. Dutch guidelines for diagnosis and therapy of proliferative lupus nephritis. Netherlands Journal of Medicine 2012; 70: 199-206. (VUmc)

1819. van Turenhout ST, Oort FA, Droste JSTS, Coupe VMH, van der Hulst RW, Loffeld RJ, Scholten P, Depla ACTM, Bouman AA, Meijer GA, Mulder CJJ, van Rossum LGM. Hemorrhoids detected at colonoscopy: an infrequent cause of false-positive fecal immunochemical test results. Gastrointestinal Endoscopy 2012; 76: 136-143. (VUmc)

1820. van Turenhout ST, Terhaar Sive Droste JS, Meijer GA, Masclee AA, Mulder CJJ. Anticipating implementation of colorectal cancer screening in The Netherlands: a nation wide survey on endoscopic supply and demand. BMC Cancer 2012; 12: 46. (VUmc)

1821. van Turenhout ST, van Rossum LGM, Oort FA, Laheij RJF, van Rijn AF, Droste JSTS, Fockens P, van der Hulst RWM, Bouman AA, Jansen JBMJ, Meijer GA, Dekker E, Mulder CJJ. Similar fecal immunochemical test results in screening and referral colorectal cancer. World Journal of Gastroenterology 2012; 18: 5397-5403. (VUmc/AMC)

1822. van Tuyl LHD, Boers M. Patient's Global Assessment of Disease Activity: What Are We Measuring?. Arthritis and Rheumatism 2012; 64: 2811-2813. (VUmc)

1823. van Tuyl LHD, Britsemmer K, Wells GA, Smolen JS, Zhang B, Funovits J, van Schaardenburg D, Felson D, Boers M. Remission in early rheumatoid arthritis defined by 28 joint counts: limited consequences of residual disease activity in the forefeet on outcome. Annals of the Rheumatic Diseases 2012; 71: 33-37. (VUmc)

1824. van Velden FH, van Beers P, Nuyts J, Velasquez LM, Hayes W, Lammertsma AA, Boellaard R, Loeckx D. Effects of rigid and non-rigid image registration on test-retest variability of quantitative [18F]FDG PET/CT studies. Eur J Nucl Med Mol Imaging 2012; 2: 10. (VUmc)

1825. van Vilsteren FGI, Alvarez Herrero L, Pouw RE, Visser M, ten Kate FJW, van Berge Henegouwen MI, Schoon EJ, Weusten BL, Bergman JJ. Radiofrequency ablation and endoscopic resection in a single session for Barrett's esophagus containing early neoplasia: a feasibility study. Endoscopy 2012; 44(12): 1096-1104. (AMC)

1826. van Vilsteren FGI, Pouw RE, Herrero LA, Peters FP, Bisschops R, Houben M, Peters FTM, Schenk BE, Weusten BLAM, Visser M, ten Kate FJW, Fockens P, Schoon EJ, Bergman JJGHM. Learning to perform endoscopic resection of esophageal neoplasia is associated with significant complications even within a structured training program. Endoscopy 2012; 44(1): 4-12. (AMC)

1827. van Vilsteren FGI, Schoon EJ, Bergman JJGHM. A one-to-one training program would be valuable in learning how to perform esophageal endoscopic mucosal resection : Reply to mannath & ragunath. Endoscopy 2012; 44(6): 633-. (AMC)

1828. Van Vilsteren M, Boot CR, Steenbeek R, Schaardenburg Dv, Voskuyl AE, Anema JR. An intervention program with the aim to improve and maintain work productivity for workers with rheumatoid arthritis: design of a randomized controlled trial and cost-effectiveness study. BMC Public Health 2012; 12: 496. (VUmc)

1829. Van Vliet MH, Horlings HM, van de Vijver MJ, Reinders MJ, Wessels LFA. Integration of clinical and gene expression data has a synergetic effect on predicting breast cancer outcome. PLoS One 2012; 7: e40358 (NKI/AMC)

1830. Van Vugt HA, Kranse R, Steyerberg EW, van der Poel HG, Busstra M, Kil P, et al. Prospective validation of a risk calculator which calculates the probability of a positive prostate biopsy in a contemporary clinical cohort. European journal of cancer 2012; 48: 1809-15 (NKI)

1831. Van Vugt HA, Roobol MJ, van der Poel HG, van Muilekom EH, Busstra M, Kil P, et al. Selecting men diagnosed with prostate cancer for active surveillance using a risk calculator: a prospective impact study. BJU Int 2012; 110: 180-7 (NKI)

1832. Van Walsum GA, de Ridder JA, Verhoef C, Bosscha K, van Gulik TM, Hesselink EJ, Ruers TJ, van den Tol MP, Nagtegaal ID, Brouwers M, van Hillegersberg R, Porte RJ, Rijken AM, Strobbe LJ, de Wilt JH; Dutch Liver Surgeons Group. Resection of liver metastases in patients with breast cancer: survival and prognostic factors. Eur J Surg Oncol 2012; 38: 910-7 (NKI/VUmc)

1833. van Wanrooij RLJ, Zwiers A, Kraal G, Bouma G. Genetic variations in interleukin-12 related genes in immune-mediated diseases. Journal of Autoimmunity 2012; 39: 359-368. (VUmc)

1834. van Weely SFE, van Denderen JC, Steultjens MPM, van der Leeden M, Nurmohamed MT, Dekker J, Dijkmans BAC, van der Horst-Bruinsma I. Moving instead of asking? performance-based tests and BASFI-questionnaire measure different aspects of physical function in ankylosing spondylitis. Arthritis Research & Therapy 2012; 14: . (VUmc)

1835. van Well GTJ, Sanders MS, Ouburg S, van Furth AM, Morre SA. Polymorphisms in Toll-Like Receptors 2, 4, and 9 Are Highly Associated with Hearing Loss in Survivors of Bacterial Meningitis. PloS one 2012; 7: . (VUmc)

1836. Van Weyenberg SJ, van Grieken NCT, van Waesberghe JH. Iron Deficiency After Non-Small Cell Lung Cancer Ileal Polypoid Angiodysplasia. Gastroenterology 2012; 142: E3-E4. (VUmc)

1837. Van Weyenberg SJ, van Grieken NCT. Jejunal pseudomelanosis. Digestive and Liver Disease 2012; 44: 355. (VUmc) 1838. Van Weyenberg SJ. To Snare a Snare, or Not to Snare?. Gastroenterology 2012; 142: E1-E2. (VUmc) 1839. Van Weyenberg SJB, van Turenhout ST, Jacobs MAJM, Bouma G, Mulder CJJ. Video capsule endoscopy for previous

overt obscure gastrointestinal bleeding in patients using anti-thrombotic drugs. Digestive Endoscopy 2012; 24: 247-254. (VUmc)

1840. van Wieringen WN, Unger K, Leday GGR, Krijgsman O, Xavier de Menezes R, Ylstra B, van de Wiel MA. Matching of array CGH and gene expression microarray features for the purpose of integrative genomic analyses. BMC Bioinformatics 2012; 13: 80. (VUmc)

1841. van Wijk BC, Willemse RB, Vandertop W, Daffertshofer A. Slowing of M1 oscillations in brain tumor patients in resting state and during movement. Clinical Neurophysiology 2012; 123: 2212-2219. (VUmc)


1842. van Zeijl CJJ, van Koppen CJ, Surovtseva OV, de Gooyer ME, Plate R, Conti P, Karstens W, Timmers M, Saeed P, Wiersinga WM, Miltenburg AMM, Fliers E, Boelen A. Complete inhibition of rhTSH-, Graves' disease IgG-, and M22-induced cAMP production in differentiated orbital fibroblasts by a low-molecular-weight TSHR antagonist. Journal Of Clinical Endocrinology And Metabolism 2012; 97(5): E781-E785. (AMC)

1843. Vandenbroucke-Grauls CMJE, Vandenbroucke JP, van der Meer JWM. Resistance after selective decontamination. Lancet Infectious Diseases 2012; 12: 180-181. (VUmc)

1844. Vanderkelen L, van der Sar A, Goddeeris BM, Michiels CW. Are bacterial lysozyme inhibitors important in bacteria-host interactions?. Communications in Agricultural and Applied Biological Sciences 2012; 77: 61-65. (VUmc)

1845. Vanneste BG, Borst GR, van den Heuvel M, Belderbos JS. Diagnose en behandeling van radiatiepneumonitis. Ned Tijdschr voor Oncol 2012,9: 344-9 (NKI)

1846. van't Westeinde SC, Horeweg N, Vernhout RM, Groen HJM, Lammers JWJ, Weenink C, Nackaerts K, Oudkerk M, Mali W, Thunnissen FB, de Koning HJ, van Klaveren RJ. The Role of Conventional Bronchoscopy in the Workup of Suspicious CT Scan Screen-Detected Pulmonary Nodules. Chest 2012; 142: 377-384. (VUmc)

1847. Varadarajulu S, Fockens P, Hawes RH. Best practices in endoscopic ultrasound-guided fine-needle aspiration. Clinical Gastroenterology And Hepatology 2012; 10(7): 697-703. (AMC)

1848. Veenemans J, Mouton J, Kluytmans J, Donnely R, Verhulst C, van Keulen P. Effect of Manganese in Test Media on In Vitro Susceptibility of Enterobacteriaceae and Acinetobacter baumannii to Tigecycline. Journal of Clinical Microbiology 2012; 50: 3077-3079. (VUmc)

1849. Veenhof AAFA, Vlug MS, van der Pas MHGM, Sietses C, van der Peet DL, de Lange-de Klerk E, Bonjer HJ, Bemelman WA, Cuesta MA. Surgical Stress Response and Postoperative Immune Function After Laparoscopy or Open Surgery With Fast Track or Standard Perioperative Care A Randomized Trial. Annals of Surgery 2012; 255: 216-221. (VUmc)

1850. Veenstra HJ, Brouwer OR, Kroon BBR, Van der Ploeg IMC, Kroon BBR, Nieweg OE. Five-year follow up of sixteen melanoma patients with a Starz I-involved sentinel node in whom completion lymph node dissection was omitted. Melanoma Res 2012; 22: 436- 9 (NKI)

1851. Veenstra HJ, Klop WMC, Speijers MJ, Lohuis PJFM, Nieweg OE, Hoekstra HJ, Balm AJM. Lymphatic drainage patterns from melanomas on the shoulder or upper trunk to cervical lymph nodes and implications for the extent of neck dissection. Ann Surg Oncol 2012; 19: 3906-12 (NKI)

1852. Veenstra HJ, Vermeeren L, Valdés Olmos RA, Nieweg OE. The additional value of lymphatic mapping with routine SPECT/CT in unselected patients with clinically localized melanoma. Ann Surg Oncol 2012; 19: 1018-23 (NKI)

1853. Venderbosch S, Doornebal J, Teerenstra S, Lemmens W, Punt CJA, Koopman M. Outcome of first line systemic treatment in elderly compared to younger patients with metastatic colorectal cancer: a retrospective analysis of the CAIRO and CAIRO2 studies of the Dutch Colorectal Cancer Group (DCCG). Acta Oncologica 2012; 51(7): 831-839. (AMC)

1854. Vens C, Sobol RW. Targeting DNA repair pathways for Cancer Therapy. Cell Death Signaling in Cancer Biology and Treatment; Daniel E. Johnson Editor, Humana Press; 2013: 137-180 (NKI)

1855. Verbakel WFAR, van Reij E, Ladenius-Lischer I, Cuijpers JP, Slotman BJ, Senan S. Clinical Application of a Novel Hybrid Intensity-Modulated Radiotherapy Technique for Stage III Lung Cancer and Dosimetric Comparison With Four Other Techniques. International Journal of Radiation Oncology Biology Physics 2012; 83: E297-E303. (VUmc)

1856. Verbeek J, Eriksson J, Syvanen S, Labots M, de Lange ECM, Voskuyl RA, Mooijer MPJ, Rongen M, Lammertsma AA, Windhorst AD. [11C]phenytoin revisited: synthesis by [11C]CO carbonylation and first evaluation as a P-gp tracer in rats. Eur J Nucl Med Mol Imaging 2012; 2: 36. (VUmc)

1857. Verbeek J, Syvanen S, Schuit RC, Eriksson J, de Lange EC, Windhorst AD, Luurtsema G, Lammertsma AA. Synthesis and preclinical evaluation of [C-11]D617, a metabolite of (R)-[C-11]verapamil. Nuclear Medicine and Biology 2012; 39: 530-539. (VUmc)

1858. Verberne LM, Maurice-Stam H, Grootenhuis MA, van Santen HM, Schouten-van Meeteren AYN. Sleep disorders in children after treatment for a CNS tumour. Journal Of Sleep Research 2012; 21(4): 461-469. (AMC)

1859. Verbrugge SE, Assaraf YG, Dijkmans BAC, Scheffer GL, Al M, den Uyl D, Oerlemans R, Chan ET, Kirk CJ, Peters GJ, Van der Heijden JW, de Gruijl TD, Scheper RJ, Jansen G. Inactivating PSMB5 Mutations and P-Glycoprotein (Multidrug Resistance-Associated Protein/ATP-Binding Cassette B1) Mediate Resistance to Proteasome Inhibitors: Ex Vivo Efficacy of (Immuno)Proteasome Inhibitors in Mononuclear Blood Cells from Patients with Rheumatoid Arthritis. Journal of Pharmacology and Experimental Therapeutics 2012; 341: 174-182. (VUmc)

1860. Verdonck-de Leeuw IM, van Nieuwenhuizen A, Leemans CR. The value of quality-of-life questionnaires in head and neck cancer. Current Opinion in Otolaryngology & Head and Neck Surgery 2012; 20: 142-147. (VUmc)

1861. Vergnenegre A, Smit EF, Toy E, Parente B, Schmitz S, Kraaij K, Soldatenkova V, Visseren-Grul C, Zanotti G, Taipale K, Moro-Sibilot D. Second-line therapy for non-small cell lung cancer in clinical practice: final results and treatment pathways from the SELECTTION observational study. Current Medical Research and Opinion 2012; 28: 1253-1262. (VUmc)

1862. Verhaegen PD, Schouten HJ, Tigchelaar-Gutter W, van Marle J, van Noorden CJ, Middelkoop E, van Zuijlen PP. Adaptation of the dermal collagen structure of human skin and scar tissue in response to stretch: an experimental study. Wound Repair And Regeneration 2012; 20(5): 658-666. (AMC)

1863. Verhaegen PDHM, van Marle J, Kuehne A, Schouten HJ, Gaffney EA, Maini PK, Middelkoop E, van Zuijlen PPM. Collagen bundle morphometry in skin and scar tissue: a novel distance mapping method provides superior measurements compared to Fourier analysis. Journal Of Microscopy-Oxford 2012; 245(1): 82-89. (AMC)

1864. Verhagen MM, Last JI, Hogervorst FB, Smeets DF, Roeleveld N, Verheijen F, Catsman-Berrevoets CE, Wulffraat NM, Cobben JM, Hiel J, Brunt ER, Peeters EA, Gómez Garcia EB, van der Knaap MS, Lincke CR, Laan LA, Tijssen MA, van Rijn MA, Majoor-Krakauer D, Visser M, van ‘t Veer LJ, Kleijer WJ, van de Warrenburg BP, Warris A, de Groot IJ, de Groot R, Broeks A, Preijers F, Kremer BH, Weemaes CM, Taylor MA, van Deuren M, Willemsen MA. Presence of ATM protein and residual kinase activity correlates with the phenotype in ataxia-telangiectasia: a genotype-phenotype study. Hum Mutat 2012; 33: 561-571 (NKI)

1865. Verhappen MH, Pouwels PJW, Ljumanovic R, van der Putten L, Knol DL, de Bree R, Castelijns JA. Diffusion-Weighted MR Imaging in Head and Neck Cancer: Comparison between Half-Fourier Acquired Single-Shot Turbo Spin-Echo and EPI Techniques. American Journal of Neuroradiology 2012; 33: 1239-1246. (VUmc)

1866. Verheul RJ, Hagenaars N, van Es T, van Gaal EVB, De Jong PHJL, Bruijns S, Mastrobattista E, Slutter B, Que I, Heldens JGM, van den Bosch H, Glansbeek HL, Hennink WE, Jiskoot W. A step-by-step approach to study the influence of N-acetylation on the adjuvanticity of N,N,N-trimethyl chitosan (TMC) in an intranasal nanoparticulate influenza virus vaccine. European Journal of Pharmaceutical Sciences 2012; 45: 467-474. (VUmc)


1867. Verhoeven M, Bystrova S, Winnubst L, Qureshi H, de Gruijl TD, Scheper RJ, Luttge R. Applying ceramic nanoporous microneedle arrays as a transport interface in egg plants and an ex-vivo human skin model. Microelectronic Engineering 2012; 98: 659-662. (VUmc)

1868. Verhoeven RH, Janssen-Heijnen ML, Saum KU, Zanetti R, Caldarella A, Holleczek B, et al. Population-based survival of penile cancer patients in Europe and the United States of America: No improvement since 1990. European journal of cancer. 2012 (NKI)

1869. Verhoof E, Maurice-Stam H, Heymans H, Grootenhuis M. Growing into disability benefits? Psychosocial course of life of young adults with a chronic somatic disease or disability. Acta Paediatrica 2012; 101(1): e19-e26. (AMC)

1870. Veringa SJE, van Dulmen-den Broeder E, Kaspers GJL, Veening MA. Blood pressure and body composition in long-term survivors of childhood acute lymphoblastic leukemia. Pediatric Blood & Cancer 2012; 58: 278-282. (VUmc)

1871. Verkade E, Bergmans AMC, Budding AE, van Belkum A, Savelkoul P, Buiting AG, Kluytmans J. Recent Emergence of Staphylococcus aureus Clonal Complex 398 in Human Blood Cultures. PloS one 2012; 7: . (VUmc)

1872. Verkade E, Bosch T, Hendriks Y, Kluytmans J. Outbreak of Methicillin-Resistant Staphylococcus aureus ST398 in a Dutch Nursing Home. Infection Control and Hospital Epidemiology 2012; 33: 624-626. (VUmc)

1873. Vermaat JS, Gerritse FL, van der Veldt AA, Roessingh WM, Niers TM, Oosting SF, Sleijfer S, Roodhart JM, Beijnen JH, Schellens JH, Gietema JA, Boven E, Richel DJ, Haanen JB, Voest EE. Validation of serum amyloid α as an independent biomarker for progression-free and overall survival in metastatic renal cell cancer patients. Eur Urol 2012; 62: 685-95 (NKI/AMC/VUmc)

1874. Vermeulen L, de Sousa e Melo F, Richel DJ, Medema JP. The developing cancer stem-cell model: clinical challenges and opportunities. Lancet Oncology 2012; 13(2): e83-e89. (AMC)

1875. Vernooij-van Langen AMM, Loeber JG, Elvers B, Triepels RH, Gille JJP, Van der Ploeg CPB, Reijntjens S, Dompeling E, nkert-Roelse JE. Novel strategies in newborn screening for cystic fibrosis: a prospective controlled study. Thorax 2012; 67: 289-295. (VUmc)

1876. Verschuur A, van Tinteren H, Graf N, Bergeron C, Sandstedt B, de Kraker J. Treatment of Pulmonary Metastases in Children With Stage IV Nephroblastoma With Risk-Based Use of Pulmonary Radiotherapy. Journal Of Clinical Oncology 2012; 30(28): 3533-3539. (AMC/NKI

1877. Verselewel de Witt Hamer PC, Robles SG, Zwinderman AH, Duffau H, Berger MS. Impact of Intraoperative Stimulation Brain Mapping on Glioma Surgery Outcome: A Meta-Analysis. J Clin Oncol 2012; 30: 2559-2565. (VUmc)

1878. Verstegen NE, Lagerwaard FJ, Senan S. Developments in early-stage NSCLC: advances in radiotherapy. Annals of Oncology 2012; 23: 46-51. (VUmc)

1879. Verweij CL. Clinical relevance of the type I interferon signature in multiple sclerosis. Pharmacogenomics 2012; 13: 1883-1884. (VUmc)

1880. Verweij FJ, Middeldorp JM, Pegtel DM. Intracellular signaling controlled by the endosomal-exosomal pathway. Communicative & Integrative Biology 2012; 5: 88-93. (VUmc)

1881. Verweij SP, Ouburg S, de Vries H, Morre SA, van Ginkel CJW, Bos H, Sebens FW. The first case record of a female patient with bubonic lymphogranuloma venereum (LGV), serovariant L2b. Sexually Transmitted Infections 2012; 88: 346-347. (VUmc)

1882. Vestjens JH, Pepels MJ, de Boer M, Borm GF, van Deurzen CH, van Diest PJ, van Dijck JA, Adang EM, Nortier JW, Rutgers EJT, Seynaeve C, Menke- Pluymers MB, Bult P, Tjan-Heijnen VC. Relevant impact of central pathology review on nodal classification in individual breast cancer patients. Ann Oncol 2012; 23: 2561-6 (NKI)

1883. Vidal-Sicart S, Valdés Olmos RA. Sentinel node for breast cancer: current situation. J Oncol. 2012 (NKI) 1884. Videler WJM, van Hee K, Reinartz SM, Georgalas C, van der Meulen FW, Fokkens WJ. Long-term low-dose antibiotics

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Thunnissen E. Negative NKX2-1 (TTF-1) as Temporary Surrogate Marker for Treatment Selection During EGFR-Mutation Analysis in Patients with Non-Small-Cell Lung Cancer. Journal of Thoracic Oncology 2012; 7: 1522-1527. (VUmc)

1886. Vincenten J, Smit EF, Ylstra B, Thunnissen FBJM. Applying biomarker testing to clinical practice in lung cancer. Lung Cancer Management 2012; 1: 145-154. (VUmc)

1887. Vinet J, van Weering HRJ, Heinrich A, Kalin RE, Wegner A, Brouwer N, Heppner FL, Van Rooijen N, Boddeke HWGM, Biber K. Neuroprotective function for ramified microglia in hippocampal excitotoxicity. Journal of Neuroinflammation 2012; 9: . (VUmc)

1888. Visscher H, Ross CJD, Rassekh SR, Barhdadi A, Dubé M, Al-Saloos H, Sandor GS, Caron HN, van Dalen EC, Kremer LC, van der Pal HJ, Brown AMK, Rogers PC, Phillips MS, Rieder MJ, Carleton BC, Hayden MR. Pharmacogenomic prediction of anthracycline-induced cardiotoxicity in children. Journal Of Clinical Oncology 2012; 30(13): 1422-1428. (AMC)

1889. Visser A, Ubbink DT, Gouma DJ, Goslings JC. Questionnaire versus telephone follow-up to detect postdischarge complications in surgical patients: randomized clinical trial. World Journal Of Surgery 2012; 36(11): 2576-2583. (AMC)

1890. Visser A, Ubbink DT, van Wijngaarden AKS, Gouma DJ, Goslings JC. Quality of Care and Analysis of Surgical Complications. Digestive Surgery 2012; 29(5): 391-399. (AMC)

1891. Visser I, de Boer AGEM, Wekking EM, van Vliet J, van Hout MSE, Schmand B, Van der Laan G, Schene AH, van Dijk FJH. The Coping with Attention and Memory Complaints Questionnaire (CAMQ): psychometric evaluation of an instrument in suspected chronic solvent-induced encephalopathy (CSE). Neuropsychological Rehabilitation 2012; 22(5): 794-808. (AMC)

1892. Visser R, Veldkamp WJH, Beijerinck D, Bun PAM, Deurenberg JJM, Imhof-Tas MW, Schuur KH, Snoeren MM, den Heeten GJ, Karssemeijer N, Broeders MJM. Increase in perceived case suspiciousness due to local contrast optimisation in digital screening mammography. European Radiology 2012; 22(4): 908-914. (AMC)

1893. Vlaming H, van Leeuwen F. Cross-talk between aging and the epigenome. Epigenomics 2012; 4: 5-7 (NKI) 1894. Vlug MS, Bartels SAL, Wind J, Ubbink DT, Hollmann MW, Bemelman WA. Which fast track elements predict early

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Deprez P, Fockens P. Efficacy of endoscopic closure of acute perforations of the gastrointestinal tract. Clinical Gastroenterology And Hepatology 2012; 10(6): 603-608. (AMC)

1896. Voets E, Wolthuis RMF. Stable government of mitosis by Greatwall: the emperor’s best servant. Mol Cell Biol 2012; 32: 1334-6 (NKI)

1897. Vogel WV, Guislain A, Kvistborg P, Schumacher TN, Haanen JB, Blank CU. Ipilimumab-induced sarcoidosis in a patient with metastatic melanoma undergoing complete remission. J Clin Oncol 2012; 30: e7-e10 (NKI)


1898. Vogel WV, Valdés Olmos RA, Tijs TJ, Gillies MF, van Elswijk G, Vogt J. Intervention to lower anxiety of 18F-FDG PET/CT patients by use of audiovisual imagery during the uptake phase before imaging. J Nucl Med Technol 2012; 40: 92-98 (NKI)

1899. Vollebergh MA, Jonkers J*, Linn SC*. Genomic instability in breast and ovarian cancers: translation into clinical predictive biomarkers. Cell Mol Life Sci 2012; 69: 223-45 (* joint corresponding authors) (NKI)

1900. von Bartheld M, van der Heijden E, Annema J. Mediastinal abscess formation after EUS-guided FNA: are patients with sarcoidosis at increased risk? Gastrointestinal Endoscopy 75(5): 1104-1107. (AMC)

1901. von Bueren AO, Bacolod MD, Hagel C, Heinimann K, Fedier A, Kordes U, Pietsch T, Koster J, Grotzer MA, Friedman HS, Marra G, Kool M, Rutkowski S. Mismatch repair deficiency: a temozolomide resistance factor in medulloblastoma cell lines that is uncommon in primary medulloblastoma tumours. British Journal Of Cancer 2012; 107(8): 1399-1408. (AMC)

1902. Von Meyenfeldt EM, Gooiker GA, van Gijn W, Post PN, van de Velde CJ, Tollenaar RA, Klomp HM, Wouters MW. The relationship between volume or surgeon specialty and outcome in the surgical treatment of lung cancer: a systematic review and meta-analysis. J Thorac Oncol 2012; 7: 1170-8 (NKI)

1903. Von Meyenfeldt EM, Wouters MW, Fat NL, Prevoo W, Burgers SA, van Sandick JW, Klomp HM. Local treatment of pulmonary metastases: from open resection to minimally invasive approach? Less morbidity, comparable local control. Surg Endosc 2012; 26: 2312-21 (NKI)

1904. von Moltke J, Trinidad NJ, Moayeri M, Kintzer AF, Wang SB, Van Rooijen N, Brown CR, Krantz BA, Leppla SH, Gronert K, Vance RE. Rapid induction of inflammatory lipid mediators by the inflammasome in vivo. Nature 2012; 490: 107-111. (VUmc)

1905. von Tresckow B, Pluetschow A, Fuchs M, Klimm B, Markova J, Lohri A, Kral Z, Greil R, Topp MS, Meissner J, Zijlstra JM, Soekler M, Stein H, Eich HT, Mueller RP, Diehl V, Borchmann P, Engert A. Dose-Intensification in Early Unfavorable Hodgkin's Lymphoma: Final Analysis of the German Hodgkin Study Group HD14 Trial. J Clin Oncol 2012; 30: 907-913. (VUmc)

1906. Vonkeman HE, deLeest HTJI, van deLaar MAFJ, vanBaarlen J, Steen KSS, Lems WF, Bijlsma JWJ, Kuipers EJ, Houben HHML, Janssen M, Dijkmans BAC. Assessment of Helicobacter pylori eradication in patients on NSAID treatment. BMC Gastroenterology 2012; 12: . (VUmc)

1907. Voorham QJM, Carvalho B, Spiertz AJ, Claes B, Mongera S, van Grieken NCT, Grabsch H, Kliment M, Rembacken B, van de Wiel MA, Quirke P, Mulder CJJ, Lambrechts D, van Engeland M, Meijer GA. Comprehensive Mutation Analysis in Colorectal Flat Adenomas. PloS one 2012; 7: . (VUmc)

1908. Voorham QJM, Carvalho B, Spiertz AJ, van Grieken NCT, Mongera S, Rondagh EJA, van de Wiel MA, Jordanova ES, Ylstra B, Kliment M, Grabsch H, Rembacken BJ, Arai T, de Bruine AP, Sanduleanu S, Quirke P, Mulder CJJ, van Engeland M, Meijer GA. Chromosome 5q Loss in Colorectal Flat Adenomas. Clin Cancer Res 2012; 18: 4560-4569. (VUmc)

1909. Vos ACW, Wildenberg ME, Arijs I, Duijvestein M, Verhaar AP, de Hertogh G, Vermeire S, Rutgeerts P, van den Brink GR, Hommes DW. Regulatory macrophages induced by infliximab are involved in healing in vivo and in vitro. Inflammatory Bowel Diseases 2012; 18(3): 401-408. (AMC)

1910. Vos CG, Hartemink KJ, Jiya TU, Feller RE, Oosterhuis JWA, Paul MA. Severe Kyphosis With Spinal Cord Compression After Resection of a Superior Sulcus Tumor. Annals of Thoracic Surgery 2012; 94: 1003-1006. (VUmc)

1911. Vos CG, Murk JLAN, Hartemink KJ, Daniels JMA, Paul MA, Debets-Ossenkopp YJ. A rare pulmonary infection caused by Arthrographis kalrae. Journal of Medical Microbiology 2012; 61: 593-595. (VUmc)

1912. Vos FM, Tielbeek JAW, Naziroglu RE, Li Z, Schueffler P, Mahapatra D, Wiebel A, Lavini C, Buhmann JM, Hege H, Stoker J, van Vliet LJ. Computational modeling for assessment of IBD: To be or not to be? Conference Proceedings : Annual International Conference Of The IEEE Engineering In Medicine And Biology Society 2012; 2012: 3974-3977. (AMC)

1913. Vos J, Oosterwijk JC, Gomez-Garcia E, Menko FH, Collee MJ, van Asperen CJ, Jansen AM, Stiggelbout AM, Tibben A. Exploring the short-term impact of DNA-testing in breast cancer patients: The counselees' perception matters, but the actual BRCA1/2 result does not. Patient Education and Counseling 2012; 86: 239-251. (VUmc)

1914. Vos JM, Minnema MC, Wijermans PW, Croockewit S, Chamuleau ME, Pals ST, Klein SK, Delforge M, van Imhoff GW, Kersten MJ. Richtlijn voor diagnostiek en behandeling van de ziekte van Waldenström. Nederlands Tijdschrift Voor Hematologie 2012; 9: 219-. (AMC)

1915. Vos MJ, Berkhof J, Hoekstra OS, Bosma I, Sizoo EM, Heimans JJ, Reijneveld JC, Sanchez E, Lagerwaard FJ, Buter J, Noske DP, Postma TJ. MRI and thallium-201 SPECT in the prediction of survival in glioma. Neuroradiology 2012; 54: 539-546. (VUmc)

1916. Vosjan MJWD, Vercammen J, Kolkman JA, Stigter-van Walsum M, Revets H, van Dongen GAMS. Nanobodies Targeting the Hepatocyte Growth Factor: Potential New Drugs for Molecular Cancer Therapy. Molecular Cancer Therapeutics 2012; 11: 1017-1025. (VUmc)

1917. Voss A, Kluytmans J, Pittet D. A new journal and new global perspective on infection control and public health. Antimicrob Resist Infect Control 2012; 1: 4. (VUmc)

1918. Vredeveld LCW, Possik PA, Smit MA, Meissl K, Michaloglou C, Horlings HM, Ajouaou A, Kortman PC, Dankort D, McMahon M, Mooi WJ, Peeper DS. Abrogation of BRAFV600E-induced senescence by PI3K pathway activation contributes to melanomagenesis. Genes Dev 2012; 26: 1055-69. (NKI)

1919. Vredeveld LCW, Possik PA, Smit MA, Meissl K, Michaloglou C, Horlings HM, Ajouaou A, Kortman PC, Dankort D, McMahon M, Mooi WJ, Peeper DS. Abrogation of BRAF(V600E)-induced senescence by PI3K pathway activation contributes to melanomagenesis. Genes & Development 2012; 26: 1055-1069. (VUmc)

1920. Vriend HJ, Op de Coul ELM, van de Laar TJW, Urbanus AT, van der Klis FRM, Boot HJ. Hepatitis C virus seroprevalence in The Netherlands. European Journal of Public Health 2012; 22: 819-821. (VUmc)

1921. Vrieze A, van Nood E, Holleman F, Salojärvi J, Kootte RS, Bartelsman JFWM, Dallinga-Thie GM, Ackermans MT, Serlie MJ, Oozeer R, Derrien M, Druesne A, van Hylckama Vlieg JET, Bloks VW, Groen AK, Heilig HGHJ, Zoetendal EG, Stroes ES, de Vos WM, Hoekstra JBL, Nieuwdorp M. Transfer of intestinal microbiota from lean donors increases insulin sensitivity in individuals with metabolic syndrome. Gastroenterology 2012; 143(4): 913-6.e7. (AMC)

1922. Vrijman C, Hosseinpour D, Bakker JG, Wolkerstorfer A, Bos JD, van der Veen JPW, Luiten RM. Provoking factors including chemicals in Dutch vitiligo patients. British Journal Of Dermatology 2012. (AMC)

1923. Vrijman C, Kroon MW, Limpens J, Leeflang MMG, Luiten RM, van der Veen JPW, Wolkerstorfer A, Spuls PI. The prevalence of thyroid disease in patients with vitiligo: a systematic review. British Journal Of Dermatology 2012; 167(6): 1224-1235. (AMC)


1924. Vrijman C, Linthorst Homan M, Limpens J, van der Veen W, Wolkerstorfer A, Terwee CB, Spuls PI. Measurement Properties of Outcome Measures for Vitiligo: A Systematic Review. Archives Of Dermatology 2012; 148(11): 1-8. (AMC)

1925. Vroemen JC, Dobbe JGG, Jonges R, Strackee SD, Streekstra GJ. Three-dimensional assessment of bilateral symmetry of the radius and ulna for planning corrective surgeries. Journal Of Hand Surgery-American Volume 2012; 37A(5): 982-988. (AMC)

1926. Walenkamp MMJ, Dobbe JGG, Streekstra GJ, Strackee SD, Schep NWL. Correctie van malunion van de radius met behulp van 3D modellen. Nederlands Tijdschrift Voor Handtherapie 2012; 11: 8-11. (AMC)

1927. Walf-Vorderwülbecke V, De Boer J, Horton SJ, van Amerongen R, Proost N, Berns A, and Williams O. Frat2 mediates the oncogenic activation of Rac by MLL fusions. Blood 2012; 120: 4819-28 (NKI)

1928. Walker KM, Pope J. Treatment of Systemic Sclerosis Complications: What to Use When First-Line Treatment Fails-A Consensus of Systemic Sclerosis Experts. Seminars in Arthritis and Rheumatism 2012; 42: 42-55. (VUmc)

1929. Walsh J, Lems WF, Karras D, Langdahl BL, Ljunggren O, Fahrleitner-Pammer A, Barrett A, Rajzbaum G, Jakob F, Marin F. Effectiveness of Teriparatide in Women Over 75 Years of Age with Severe Osteoporosis: 36-Month Results from the European Forsteo Observational Study (EFOS). Calcified Tissue International 2012; 90: 373-383. (VUmc)

1930. Wang KK, Tian JM, Gorospe E, Penfield J, Prasad G, Goddard T, Wong Kee Song M, Buttar NS, Lutzke L, Krishnadath S. Medical and endoscopic management of high-grade dysplasia in Barrett's esophagus. Diseases Of The Esophagus 2012; 25(4): 349-355. (AMC)

1931. Warmoes M, Jaspers JE, Pham TV, Piersma SR, Oudgenoeg G, Massink MP, Waisfisz Q, Rottenberg S, Boven E, Jonkers J, Jimenez CR. Proteomics of mouse BRCA1-deficient mammary tumors identifies DNA repair proteins with potential diagnostic and prognostic value in human breast cancer. Mol Cell Proteomics 2012; 11: M111.013334 (VUmc/NKI)

1932. Warren H, Dudbridge F, Fletcher O et al. 9q31.2-rs865686 as a susceptibility locus for estrogen receptor-positive breast cancer: evidence from the Breast Cancer Association Consortium. Cancer Epidemiol Biomarkers Prev 2012; 21: 1783-91 (NKI)

1933. Wartenberg H. Hirnatrophie bei chronischen Schmerzpatienten? Journal Fur Anasthesie Und Intensivbehandlung 2012; 22: 215-. (AMC)

1934. Wassenberg M, Kluytmans J, Erdkamp S, Bosboom R, Buiting A, van Elzakker E, Melchers W, Thijsen S, Troelstra A, Vandenbroucke-Grauls C, Visser C, Voss A, Wolffs P, Wulf M, van Zwet T, de Wit A, Bonten M. Costs and benefits of rapid screening of methicillin-resistant Staphylococcus aureus carriage in intensive care units: a prospective multicenter study. Critical Care 2012; 16: . (VUmc)

1935. Weber S, Tian HJ, Van Rooijen N, Pirofski LA. A Serotype 3 Pneumococcal Capsular Polysaccharide-Specific Monoclonal Antibody Requires Fc gamma Receptor III and Macrophages To Mediate Protection against Pneumococcal Pneumonia in Mice. Infection and Immunity 2012; 80: 1314-1322. (VUmc)

1936. Weder P, Schumacher TNM, Spits H, Luiten RM. Testing for HLA/peptide tetramer-binding to the T cell receptor complex on human T lymphocytes. Research In Immunology 2012; 17: 88-96. (AMC)

1937. Weerdenburg EM, Abdallah AM, Mitra S, de Punder K, van der Wel NN, Bird S, Appelmelk BJ, Bitter W, van der Sar AM. ESX-5-deficient Mycobacterium marinum is hypervirulent in adult zebrafish. Cellular Microbiology 2012; 14: 728-739. (VUmc)

1938. Wefel JS, Schagen SB. Chemotherapyrelated cognitive dysfunction. Curr Neurol Neurosci Rep 2012; 12: 267-75 (NKI) 1939. Wegdam W, Moerland PD, Meijer D, de Jong SM, Hoefsloot HC, Kenter GG, Buist MR, Aerts JM. A critical assessment of

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1940. Weischer M, Nordestgaard BG, Pharoah P et al, Schmidt MK and Bojesen S. CHEK2*1100delC Heterozygosity in Women With Breast Cancer Associated With Early Death, Breast Cancer-Specific Death, and Increased Risk of a Second Breast Cancer. J Clin Oncol 2012; 30: 4308-16 (NKI)

1941. Weiss A, van den Bergh H, Griffioen AW, Nowak-Sliwinska P. Angiogenesis inhibition for the improvement of photodynamic therapy: The revival of a promising idea. Biochimica et Biophysica Acta-Reviews on Cancer 2012; 1826: 53-70. (VUmc)

1942. Weiss N, van Leeuwen TG, Kalkman J. Doppler-based lateral motion tracking for optical coherence tomography. Optics Letters 2012; 37(12): 2220-2222. (AMC)

1943. Weisser SB, Van Rooijen N, Sly LM. Depletion and reconstitution of macrophages in mice. Journal of Visualized Experiments 2012; 1: . (VUmc)

1944. Wendel M, Bazhenova L, Boshuizen R, Kolatkar A, Honnatti M, Cho EH, Marrinucci D, Sandhu A, Perricone A, Thistlethwaite P, Bethel K, Nieva J, Heuvel M, Kuhn P. Fluid biopsy for circulating tumor cell identification in patients with early-and late-stage non-small cell lung cancer: a glimpse into lung cancer biology. Phys Biol 2012; 9: 016005 (NKI)

1945. Wendling M, McDermot LN, Mans A, Olaciregui-Ruiz I, Pecharroman- Gallego R, Sonke JJ, Stroom J, van Herk M, Mijnheer BJ. In acqua vivo EPID dosimetry. Med Phys 2012; 39: 367-77 (NKI)

1946. Wensveen FM, Derks IAM, van Gisbergen KPJM, de Bruin AM, Meijers JCM, Yigittop H, Nolte MA, Eldering E, van Lier RAW. BH3-only protein Noxa regulates apoptosis in activated B cells and controls high-affinity antibody formation. Blood 2012; 119(6): 1440-1449. (AMC)

1947. Wensveen FM, Unger PA, Kragten NAM, Derks IAM, ten Brinke A, Arens R, van Lier RAW, Eldering E, van Gisbergen KPJM. CD70-driven costimulation induces survival or Fas-mediated apoptosis of T cells depending on antigenic load. Journal Of Immunology 2012; 188(9): 4256-4267. (AMC)

1948. Wensveen FM, van Gisbergen KPJM, Eldering E. The fourth dimension in immunological space: how the struggle for nutrients selects high-affinity lymphocytes. Immunological Reviews 2012; 249(1): 84-103. (AMC)

1949. Wentholt IME, Bras J, Kroon FHM, Nieveen van Dijkum EJM, Fliers E. Vitamin D, or wait and see? Netherlands Journal Of Medicine 2012; 70(6): 292-293. (AMC)

1950. Wessels R, de Bruin DM, Faber DJ, van Boven HH, Vincent AD, van Leeuwen TG, van Beurden M, Ruers TJM. Optical coherence tomography in vulvar intraepithelial neoplasia. Journal Of Biomedical Optics 2012; 17(11): 116022-. (AMC)

1951. Wessels R, de Bruin DM, Faber DJ, van Boven HH, Vincent AD, van Leeuwen TG, van Beurden M, Ruersa TJ. Optical coherence tomography in vulvar intraepithelial neoplasia. J Biomed Opt 2012; 17: 116022 (NKI)

1952. Westerman BA, Blom M, Tanger E, van der Valk M, Song JY, van Santen M, Gadiot J, Cornelissen-Steijger P, Zevenhoven J, Prosser HM, Uren A, Aronica E, van Lohuizen M. GFAP-Cre-mediated transgenic activation of Bmi1 results in pituitary tumors. Plos One 2012; 7(5): e35943-. (AMC)


1953. Westerman BA, Blom M, Tanger E, van der Valk M, Song JY, van Santen M, Gadiot J, Cornelissen-Steijger P, Zevenhoven J, Prosser HM, Uren A, Aronica E, van Lohuizen M. GFAP-Cre- Mediated Transgenic Activation of Bmi1 Results in Pituitary Tumors. PLoS One 2012; 7: e35943 (NKI)

1954. Westerman LJ, Stel HV, Schipper MEI, Bakker LJ, Neefjes-Borst EA, van den Brande JHM, Boel ECH, Seldenrijk KA, Siersema PD, Bonten MJM, Kusters JG. Development of a Real-Time PCR for Identification of Brachyspira Species in Human Colonic Biopsies. PloS one 2012; 7: . (VUmc)

1955. Westermann A, Mella O, Van Der Zee J, Jones EL, Steen-Banasik E, Koper P, Uitterhoeve AL, De Wit R, Van Der Velden J, Burger C, Schem BC, Van Der Wilt C, Dahl O, Prosnitz LR, van Tinteren H. Long-term survival data of triple modality treatment of stage IIB-III-IVA cervical cancer with the combination of radiotherapy, chemotherapy and hyperthermia - an update. Int J Hyperthermia 2012; 28: 549-553 (NKI)

1956. Westermann A, Mella O, van der Zee J, Jones EL, van der Steen-Banasik E, Koper P, Uitterhoeve ALJ, de Wit R, van der Velden J, Burger C, Schem BC, van der Wilt Cl, Dahl O, Prosnitz LR, van Tinteren H. Long-term survival data of triple modality treatment of stage IIB-III-IVA cervical cancer with the combination of radiotherapy, chemotherapy and hyperthermia - an update. International Journal Of Hyperthermia 2012; 28(6): 549-553. (AMC)

1957. Westers TM, Ireland R, Kern W, Alhan C, Balleisen JS, Bettelheim P, Burbury K, Cullen M, Cutler JA, la Porta MG, Drager AM, Feuillard J, Font P, Germing U, Haase D, Johansson U, Kordasti S, Loken MR, Malcovati L, te Marvelde JG, Matarraz S, Milne T, Moshaver B, Mufti GJ, Ogata K, Orfao A, Porwit A, Psarra K, Richards SJ, Subira D, Tindell V, Vallespi T, Valent P, van der Velden VHJ, de Witte TM, Wells DA, Zettl F, Bene MC, van de Loosdrecht AA. Standardization of flow cytometry in myelodysplastic syndromes: a report from an international consortium and the European LeukemiaNet Working Group. Leukemia 2012; 26: 1730-1741. (VUmc)

1958. Westers TM, van der Velden VHJ, Alhan C, Bekkema R, Bijkerk A, Brooimans RA, Cali C, Drager AM, de Haas V, Homburg C, de Jong A, Kuiper-Kramer PA, Leenders M, Lommerse I, Marvelde JGT, van der Molen-Sinke J, Moshaver B, Mulder AB, Preijers FWMB, Schindhelm RK, van der Sluijs A, van Wering ER, Westra AH, van de Loosdrecht AA. Implementation of flow cytometry in the diagnostic work-up of myelodysplastic syndromes in a multicenter approach: Report from the Dutch Working Party on Flow Cytometry in MDS. Leukemia Research 2012; 36: 422-430. (VUmc)

1959. Weterman MAJ, Sorrentino V, Kasher PR, Jakobs ME, van Engelen BGM, Fluiter K, de Wissel MB, Sizarov A, Nürnberg G, Nürnberg P, Zelcer N, Schelhaas HJ, Baas F. A frameshift mutation in LRSAM1 is responsible for a dominant hereditary polyneuropathy. Human Molecular Genetics 2012; 21(2): 358-370. (AMC)

1960. Wevers MR, Hahn DE, Verhoef S, Bolhaar MD, Ausems MG, Aaronson NK, Bleiker EM. Breast cancer genetic counseling after diagnosis but before treatment: Treatment consequences and psychological impact. Pat Educ Counsel 2012; 89: 89-95 (NKI)

1961. White RE, Raemer PC, Naresh KN, Meixlsperger S, Pinaud L, Rooney C, Savoldo B, Coutinho R, Boedoer C, ribben J, brahim HA, ower M, ourse JP, andhi MK, iddeldorp J, ader FZ, urray P, uenz C, llday MJ. EBNA3B-deficient EBV promotes B cell lymphomagenesis in humanized mice and is found in human tumors. Journal of Clinical Investigation 2012; 122: 1487-1502. (VUmc)

1962. Widjajanto PH, Sutaryo S, Purwanto I, Ven PM, Veerman AJP. Early Response to Dexamethasone as Prognostic Factor: Result from Indonesian Childhood WK-ALL Protocol in Yogyakarta. J Oncol 2012; 2012: 417941. (VUmc)

1963. Wiegerinck JI, Oudhof B, Weert HC, Struijs PA. Hielpijn bij kinderen. Huisarts En Wetenschap 2012; 55(6): 260-265. (AMC)

1964. Wielders CCH, Kampschreur LM, Schneeberger PM, Jager MM, Hoepelman AIM, Leenders ACAP, Hermans MHA, Wever PC. Early Diagnosis and Treatment of Patients with Symptomatic Acute Q Fever Do Not Prohibit IgG Antibody Responses to Coxiella burnetii. Clinical and Vaccine Immunology 2012; 19: 1661-1666. (VUmc)

1965. Wierda E, Reesink HJ, Bruining H, van Delden OM, Kloek JJ, Bresser P. Successful pulmonary endarterectomy in a patient with klinefelter syndrome. Case Reports In Pulmonology 2012; 2012: 104195-. (AMC)

1966. Wiersema AM, Jongkind V, Bruijninckx CMA, Reijnen MMPJ, Vos JA, van Delden OM, Zeebregts CJ, Moll FL. Prophylactic perioperative anti-thrombotics in open and endovascular abdominal aortic aneurysm (AAA) surgery: a systematic review. European Journal Of Vascular And Endovascular Surgery 2012; 44(4): 359-367. (AMC)

1967. Wikman H, Lamszus K, Detels N, Uslar L, Wrage M, Benner C, Hohensee I, Ylstra B, Eylmann K, Zapatka M, Sauter G, Kemming D, Glatzel M, Muller V, Westphal M, Pantel K. Relevance of PTEN loss in brain metastasis formation in breast cancer patients. Breast Cancer Research 2012; 14: R49. (VUmc)

1968. Wildeman M A, Novalic Z, Verkuijlen SA, Juwana H, Huitema AD, Tan IB, Middeldorp JM, de Boer JP, Greijer AE. Cytolytic virus activation therapy for epstein-barr virus-driven tumors. Clin Cancer Res 2012; 18: 5061-70 (NKI/VUmc)

1969. Wildeman MA, Fles R, Adham M, Mayangsari ID, Luirink I, Sandberg M, Vincent AD, Fardizza F, Musa Z, Armiyanto, Middeldorp JM, Gerritsen G, Suwanto R, Tan IB. Short-term effect of different teaching methods on nasopharyngeal carcinoma for general practitioners in Jakarta, Indonesia. PLoS One 2012; 7: e32756 (NKI/VUmc)

1970. Wildenberg ME, van den Brink GR. A major advance in ex vivo intestinal organ culture. GUT 2012; 61(7): 961-962. (AMC)

1971. Wildenberg ME, Vos ACW, Wolfkamp SCS, Duijvestein M, Verhaar AP, te Velde AA, van den Brink GR, Hommes DW. Autophagy attenuates the adaptive immune response by destabilizing the immunologic synapse. Gastroenterology 2012; 142(7): 1493-503.e6. (AMC)

1972. Wildschut ED, Ahsman MJ, Houmes RJ, Pokorna P, de Wildt SN, Mathot RAA, Tibboel D. Pharmacotherapy in neonatal and pediatric extracorporeal membrane oxygenation (ECMO). Current Drug Metabolism 2012; 13(6): 767-777. (AMC)

1973. Wilhelm AJ, de Graaf P, Veldkamp AI, Janssen JJWM, Huijgens PC, Swart EL. Population pharmacokinetics of ciclosporin in haematopoietic allogeneic stem cell transplantation with emphasis on limited sampling strategy. British Journal of Clinical Pharmacology 2012; 73: 553-563. (VUmc)

1974. Wilting RH, Dannenberg JH. Epigenetic mechanisms in tumorigenesis, tumor cell heterogeneity and drug resistance. Drug Resist Updat 2012; 15: 21-38 (NKI)

1975. Wilting SM, Snijders PJ, Verlaat W, Jaspers A, van de Wiel MA, van Wieringen WN, Meijer GA, Kenter GG, Yi Y, le Sage C, Agami R, Meijer CJ, Steenbergen RD. Altered microRNA expression associated with chromosomal changes contributes to cervical carcinogenesis. Oncogene 2012; 3; 32: 106-16 (NKI)

1976. Wilting SM, Verlaat W, Jaspers A, Makazaji NA, Agami R, Meijer CJ, Snijders PJ, Steenbergen RD. Methylation-mediated transcriptional repression of microRNAs during cervical carcinogenesis. Epigenetics. 2013; 8 (NKI)

1977. Wind BS, Meesters AA, Kroon MW, Beek JF, van der Veen JPW, van der Wal AC, Bos JD, Wolkerstorfer A. Formation of fibrosis after nonablative and ablative fractional laser therapy. Dermatologic Surgery 2012; 38(3): 437-442. (AMC)


1978. Wirz S, Nadstawek J, Elsen C, Junker U, Wartenberg HC. Laxative management in ambulatory cancer patients on opioid therapy: a prospective, open-label investigation of polyethylene glycol, sodium picosulphate and lactulose. European Journal Of Cancer Care 2012; 21(1): 131-140. (AMC)

1979. Wishart GC, Bajdik CD, Dicks E et al. PREDICT Plus: development and validation of a prognostic model for early breast cancer that includes HER2. Br J Cancer 2012; 107: 800-7 (NKI)

1980. Wisniewska-Kruk J, Hoeben KA, Vogels IMC, Gaillard PJ, van Noorden CJF, Schlingemann RO, Klaassen I. A novel co-culture model of the blood-retinal barrier based on primary retinal endothelial cells, pericytes and astrocytes. Experimental Eye Research 2012; 96(1): 181-190. (AMC)

1981. Wittenberg R, Peters J, Weber M, Lely R, Cobben L, Prokop M, Schaefer-Prokop C. Stand-alone performance of a computer-assisted detection prototype for detection of acute pulmonary embolism: a multi-institutional comparison. British Journal of Radiology 2012; 85: 758-764. (VUmc)

1982. Wohlleber D, Kashkar H, Gartner K, Frings MK, Odenthal M, Hegenbarth S, Borner C, Arnold B, Hammerling G, Nieswandt B, Van Rooijen N, Limmer A, Cederbrant K, Heikenwalder M, Pasparakis M, Protzer U, Dienes HP, Kurts C, Kronke M, Knolle PA. TNF-Induced Target Cell Killing by CTL Activated through Cross-Presentation. Cell Reports 2012; 2: 478-487. (VUmc)

1983. Wolf SL, Barton DL, Qin R, Wos EJ, Sloan JA, Liu H, Aaronson NK, Satele DV, Mattar BI, Green Nb, Loprinzi CL. The relationship between numbness, tingling and shooting/burning pain in patients with chemotherapy induced peripheral neuropathy (CIPN) as measured by the EORTC QLQ-CIPN20 instrument. Support Care Cancer 2012; 20: 625-32 (NKI)

1984. Wolfkamp SCS, Verstege MI, Vogels EWM, Meisner S, Verseijden C, Stokkers PCF, te Velde AA. Single nucleotide polymorphisms in C-type lectin genes, clustered in the IBD2 and IBD6 susceptibility loci, may play a role in the pathogenesis of inflammatory bowel diseases. European Journal Of Gastroenterology & Hepatology 2012; 24(8): 965-970. (AMC)

1985. Wolkers MC, Gerlach C, Arens R, Janssen EM, Fitzgerald P, Schumacher TN, Medema JP, Green DR, Schoenberger SP. Nab2 regulates secondary CD8+ T-cell responses through control of TRAIL expression. Blood 2012; 119(3): 798-804. (AMC)

1986. Wolkers MC, Gerlach C, Arens R, Janssen EM, Fitzgerald P, Schumacher TN, Medema JP, Green DR, Schoenberger SP. Nab2 regulates secondary CD8+ T-cell responses through control of TRAIL expression. Blood 2012; 119: 798-804 (NKI)

1987. Wondergem MJ, Zijlstra JM, de Rooij M, Visser OJ, Huijgens PC, Zweegman S. Improving survival in patients with transformed B cell non Hodgkin lymphoma: consolidation with 90Yttrium ibritumomab tiuxetan-BEAM and autologous stem cell transplantation. British Journal of Haematology 2012; 157: 395-397. (VUmc)

1988. Wonders J, De Boer NK, Van Weyenberg SJ. Spot diagnosis: Eruptive melanocytic naevi during azathioprine therapy in Crohn's disease. Journal of Crohns & Colitis 2012; 6: 636. (VUmc)

1989. Wouters MW, Gooiker GA, van Sandick JW, Tollenaar RA. The volume-outcome relation in the surgical treatment of esophageal cancer: a systematic review and meta-analysis. Cancer 2012; 118: 1754-63 (NKI)

1990. Wu X, Northcott PA, Dubuc A, Dupuy AJ, Shih DJH, Witt H, Croul S, Bouffet E, Fults DW, Eberhart CG, Garzia L, van Meter T, Zagzag D, Jabado N, Schwartzentruber J, Majewski J, Scheetz TE, Pfister SM, Korshunov A, Li XN, Scherer SW, Cho YJ, Akagi K, MacDonald TJ, Koster J, McCabe MG, Sarver AL, Collins VP, Weiss WA, Largaespada DA, Collier LS, Taylor MD. Clonal selection drives genetic divergence of metastatic medulloblastoma. Nature 2012; 482(7386): 529-533. (AMC)

1991. Wu YL, Sommers JA, Khan I, de Winter JP, Brosh RM. Biochemical Characterization of Warsaw Breakage Syndrome Helicase. Journal of Biological Chemistry 2012; 287: 1007-1021. (VUmc)

1992. Wurdinger T, Gatson NN, Balaj L, Kaur B, Breakefield XO, Pegtel DM. Extracellular vesicles and their convergence with viral pathways. Advances in Virology 2012; 2012: 767694. (VUmc)

1993. Xiang S, Dong HH, Liang HF, He SQ, Zhang W, Li CH, Zhang BX, Zhang BH, Jing K, Tomlinson S, Van Rooijen N, Jiang L, Cianflone K, Chen XP. Oval Cell Response Is Attenuated by Depletion of Liver Resident Macrophages in the 2-AAF/Partial Hepatectomy Rat. PloS one 2012; 7: . (VUmc)

1994. Xue W, Pacik D, Boellaard W, Breda A, Botoca M, Rassweiler J, van Cleynenbreugel B, de la Rosette J. Management of single large nonstaghorn renal stones in the CROES PCNL global study. Journal Of Urology 2012; 187(4): 1293-1297. (AMC)

1995. Yan ZJ, Guo R, Paramasivam M, Shen WP, Ling C, Fox D, Wang YC, Oostra AB, Kuehl J, Lee DY, Takata M, Hoatlin ME, Schindler D, Joenje H, de Winter JP, Li L, Seidman MM, Wang WD. A Ubiquitin-Binding Protein, FAAP20, Links RNF8-Mediated Ubiquitination to the Fanconi Anemia DNA Repair Network. Molecular Cell 2012; 47: 61-75. (VUmc)

1996. Yang TJ, Haimovitz-Friedman A, Verheij M. Anticancer therapy and apoptosis imaging. Exp Oncol 2012; 34: 269-76 (NKI)

1997. Yaqub M, van Berckel BNM, Schuitemaker A, Hinz R, Turkheimer FE, Tomasi G, Lammertsma AA, Boellaard R. Optimization of supervised cluster analysis for extracting reference tissue input curves in (R)-[C-11]PK11195 brain PET studies. Journal of Cerebral Blood Flow and Metabolism 2012; 32: 1600-1608. (VUmc)

1998. Yick CY, Ferreira DS, Annoni R, von der Thüsen JH, Kunst PW, Bel EH, Lutter R, Mauad T, Sterk PJ. Extracellular matrix in airway smooth muscle is associated with dynamics of airway function in asthma. Allergy 2012; 67(4): 552-559. (AMC)

1999. Yield van Lier MG, Leenen CH, Wagner A, Ramsoekh D, Dubbink HJ, van den Ouweland AM, Westenend PJ, de Graaf EJ, Wolters LM, Vrijland WW, Kuipers EJ, van Leerdam ME, Steyerberg EW, Dinjens WN; LIMO Study Group. of routine molecular analyses in colorectal cancer patients ≤70 years to detect underlying Lynch syndrome. J Pathol 2012; 226: 764-74 (NKI)

2000. Yokoe M, Takada T, Strasberg SM, Solomkin JS, Mayumi T, Gomi H, Pitt HA, Gouma DJ, Garden OJ, Büchler MW, Kiriyama S, Kimura Y, Tsuyuguchi T, Itoi T, Yoshida M, Miura F, Yamashita Y, Okamoto K, Gabata T, Hata J, Higuchi R, Windsor JA, Bornman PC, Fan ST, Singh H, de Santibanes E, Kusachi S, Murata A, Chen XP, Jagannath P, Lee S, Padbury R, Chen MF. New diagnostic criteria and severity assessment of acute cholecystitis in revised Tokyo Guidelines. Journal Of Hepato-Biliary-Pancreatic Sciences 2012; 19(5): 578-585. (AMC)

2001. Yuruk K, Bartels SA, Milstein DMJ, Bezemer R, Biemond BJ, Ince C. Red blood cell transfusions and tissue oxygenation in anemic hematology outpatients. Transfusion 2012; 52(3): 641-646. (AMC)

2002. Yuruk K, Bezemer R, Euser M, Milstein DMJ, de Geus HHR, Scholten EW, de Mol BAJM, Ince C. The effects of conventional extracorporeal circulation versus miniaturized extracorporeal circulation on microcirculation during cardiopulmonary bypass-assisted coronary artery bypass graft surgery. Interactive Cardiovascular And Thoracic Surgery 2012; 15(3): 364-370. (AMC)


2003. Zaal A, Louwers JA, Berkhof J, Kocken M, ter Harmsel WA, Graziosi GCM, Spruijt JWM, Balas C, Papagiannakis E, Snijders PJF, Meijer CJLM, van Kemenade FJ, Verheijen RHM. Agreement between colposcopic impression and histological diagnosis among human papillomavirus type 16-positive women: a clinical trial using dynamic spectral imaging colposcopy. BJOG-An International Journal of Obstetrics and Gynaecology 2012; 119: 537-544. (VUmc)

2004. Zaal A, Peyrot WJ, Berns PMJJ, van der Burg MEL, Veerbeek JHW, Trimbos JB, Cadron I, van Diest PJ, van Wieringen WN, Krijgsman O, Meijer GA, Piek JMJ, Timmers PJ, Vergote I, Verheijen RHM, Ylstra B, Zweemer RP. Genomic aberrations relate early and advanced stage ovarian cancer. Cell Oncol 2012; 35: 181-188. (VUmc)

2005. Zaknum JJ, Gianmarile F, Valdés Olmos RA, Vidal Sicart S, Mariani G. Changing paradigms in radioguided surgery and intraoperative imaging: the GOSTT concept. Eur J Nucl Med Mol Imaging 2012; 39: 1-3 (NKI)

2006. Zander SA, Kersbergen A, Sol W, Gonggrijp M, van de Wetering K, Jonkers J, Borst P, Rottenberg S. Lack of ABCG2 shortens latency of BRCA1-deficient mammary tumors and this is not affected by genistein or resveratrol. Cancer Prev Res 2012; 5: 1053-60 (NKI/AMC)

2007. Zander SA, Sol W, Greenberger L, Zhang Y, van Tellingen O, Jonkers J, Borst P, Rottenberg S. EZN-2208 (PEGSN38) overcomes ABCG2-mediated topotecan resistance in BRCA1- deficient mouse mammary tumors. PLoS One 2012; 7: e45248 (NKI/AMC)

2008. Zander SAL, Beijnen HJ, Van Tellingen O. Sensitive method for plasma and tumor Ko143 quantification using reversed-phase high-performance liquid chromatography and fluorescence detection. J Chromatogr B Analyt Technol Biomed Life Sci 2012 (NKI)

2009. Zeerleder S, van Oers M. Aleukemic variant of mast cell leukemia. Blood 2012; 119(9): 1961-. (AMC) 2010. Zeguers M, de Haes HCJM, Zandbelt LC, ter Hoeven CL, Franssen SJ, Geijsen DD, Koning CCE, Smets EMA. The

information needs of new radiotherapy patients: how to measure? Do they want to know everything? And if not, why? International Journal Of Radiation Oncology Biology Physics 2012; 82(1): 418-424. (AMC)

2011. Zhang Z, Sun D, Hutajulu SH, Nawaz I, Nguyen Van D, Huang G, Haryana SM, Middeldorp JM, Ernberg I, Hu LF. Development of a Non-Invasive Method, Multiplex Methylation Specific PCR (MMSP), for Early Diagnosis of Nasopharyngeal Carcinoma. PloS one 2012; 7: e45908. (VUmc)

2012. Zhou D, Chen YT, Chen FL, Gallup M, Vijmasi T, Bahrami AF, Noble LB, Van Rooijen N, McNamara NA. Critical Involvement of Macrophage Infiltration in the Development of Sjogren's Syndrome-Associated Dry Eye. American Journal of Pathology 2012; 181: 753-760. (VUmc)

2013. Zhu P, Hata R, Ogasawara M, Cao F, Kameda K, Yamauchi K, Schinkel AH, Maeyama K, Sakanaka M. Targeted disruption of organic cation transporter 3 (Oct3) ameliorates ischemic brain damage through modulating histamine and regulatory T cells. J Cereb Blood Flow Metab 2012; 32: 1897-908 (NKI)

2014. Ziech MLW, Lavini C, Caan MWA, Nio CY, Stokkers PCF, Bipat S, Ponsioen CY, Nederveen AJ, Stoker J. Dynamic contrast-enhanced MRI in patients with luminal Crohn's disease. European Journal Of Radiology 2012; 81(11): 3019-3027. (AMC)

2015. Zijlmans HJ, Punt S, Fleuren GJ, Trimbos JB, Kenter GG, Gorter A. Role of IL-12p40 in cervical carcinoma. Br J Cancer 2012; 107: 1956-62 (NKI/VUmc)

2016. Zondervan PJ, Gozen AS, Opondo D, Rassweiler JJ, de la Rosette JJ, Laguna MP. Partial 2017. Zsíros J, Brugières L, Brock P, Roebuck D, Maibach R, Child M, Morland B, Casanova M, Pariente D, Paris C, de

Camargo B, Ronghe M, Zimmermann A, Plaschkes J, Czauderna P, Perilongo G. Efficacy of irinotecan single drug treatment in children with refractory or recurrent hepatoblastoma--a phase II trial of the childhood liver tumour strategy group (SIOPEL). European Journal Of Cancer 2012; 48(18): 3456-3464. (AMC)

2018. Zurolo E, de Groot M, Iyer A, Anink J, van Vliet EA, Heimans JJ, Reijneveld JC, Gorter JA, Aronica E. Regulation of Kir4.1 expression in astrocytes and astrocytic tumors: a role for interleukin-1 beta. Journal of Neuroinflammation 2012; 9: 280. (VUmc)

2019. Zuurbier L, Petricoin EF, Vuerhard MJ, Calvert V, Kooi C, Buijs-Gladdines JGCA, Smits WK, Sonneveld E, Veerman AJP, Kamps WA, Horstmann M, Pieters R, Meijerink JPP. The significance of PTEN and AKT aberrations in pediatric T-cell acute lymphoblastic leukemia. Haematologica-The Hematology Journal 2012; 97: 1405-1413. (VUmc)

2020. Zwaveling S, Tytgat GAM, van der Zee DC, Wijnen MHWA, Heij HA. Is complete surgical resection of stage 4 neuroblastoma a prerequisite for optimal survival or may >95 % tumour resection suffice? Pediatric Surgery International 2012; 28(10): 953-959. (AMC/VUmc)

2021. Zweegman S, Lokhorst HM, Levin MD, de Waal E, Bos GM, Kersten MJ, Ypma P, Klein SK, Minnema MC, Sonneveld P. Richtlijnen behandeling multipel myeloom 2012. Nederlands Tijdschrift Voor Hematologie 2012; 9: 300-. (AMC)

2022. Zweers SJLB, Booij KAC, Komuta M, Roskams T, Gouma DJ, Jansen PLM, Schaap FG. The human gallbladder secretes fibroblast growth factor 19 into bile: towards defining the role of fibroblast growth factor 19 in the enterobiliary tract. Hepatology 2012; 55(2): 575-583. (AMC)

2023. Zwiers A, Kraal L, Kraan TC, Wurdinger T, Bouma G, Kraal G. Cutting Edge: A Variant of the IL-23R Gene Associated with Inflammatory Bowel Disease Induces Loss of MicroRNA Regulation and Enhanced Protein Production. J Immunol 2012; 188: 1573-1577. (VUmc)

annual r eport 2012 - oncology graduate school · throughout 2012, we welcomed 55 international...

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