2 0 1 2 N AV C C AtA l o g

Premium nutraceuticals for Zoo, Aquarium & Companion Species

Exclusive manufacturers and distributors of: Imuno-2865 , Serenin Vet , SHaNa Vet , Eye-SEA , Ocu-GLO RxTM TM TM TM

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QUALITY CONTROLThe FDA does not regulate the purity of a supplement, so how do you know which products to trust for your animals?

Animal Necessity supplements are certied under FDA Good Manufacturing Practice (GMP) regulations. You can be condent that each ingredient proudly listed on our labels is sourced from the highest quality, pharmaceutical grade material available and handled with the strictest manufacturing controls in the world.

GMP Certified | Formulated by PHD and DVM Collaboration | Pharmaceutical Grade Materials Patented Formulas | Peer Reviewed, Published Clinical Studies Trusted by Aquarium and Zoo Veterinarians Around the WorldGMPs are a system of procedures and documentation, written and analytical, to ensure that the product produced has the identity, strength, composition, quality, and purity that it claims. GMPs apply to all activities associated with manufacturing, packaging, holding, and distribution. GMPs cover areas such as personnel, plant and grounds, sanitation of building and facilities, equipment and utensils, quality assurance/control and laboratory operations, production and process controls, warehousing, distribution and post-distribution processes, and records retention. Source: US Food and Drug Administration www.FDA.govThese statements have not been evaluated by the Food and Drug Administration. Products may appear dierently than presented. These products are not intended to treat, diagnose, cure or prevent any disease.

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CATALOG LIST2-7 8 - 15 Company Info List of Proprietary Blends 16 - 21 22 - 23 Imuno-2865 Serenin Vet Eye-SEATM TM TM

Ocu-GLO RxTM

TM

SHaNa Vet (Capsules & Cream) Multi-34 Vita-13 Artichoke and Milk Thistle Digestin Vet Alpha Lipoic Acid Neuroplex Joint Guard Omega-3 Vinpocetine Pinebark Extract with Pureway C Oxy-IN Spirulina Vitamin B-1 (Thiamin) Vitamin D3 Vitamin E

List of Speciality Blends

Other Top Products

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COMPANY OVERVIEWAnimal Necessity's mission is to provide a comprehensive approach to animal wellness, by incorporating the latest research with pharmaceutical grade nutraceuticals to help animals live healthier lives. We seek to drive advancement in the eld through natural, holistic and scientic methods.Who We AreAnimal Necessity focuses on delivering high quality nutritional products and services to veterinary health professionals around the world. Our holistic approach to health maintenance has been developed over the past 35 years by Orthomolecular Nutritionist, Dr. Norma Pestano. Through her extensive research, Dr. Pestano seeks to maintain health and prevent diseases by optimizing nutritional intake, complemented with vitamin and supplement protocols. Dr. Pestano has partnered with leading DVMs and Board Certified Veterinary Specialists to apply many of these human based protocols towards veterinarian specific use. In 2012 over twodozen products are now available with dosing for large and small animal nutrition. Animal Necessity remains committed to gathering and delivering the latest and most relevant science related to Complementary and Alternative Medicine that will support Veterinarian Health Professionals.

Commitment to ScienceThe Animal Necessity Scientific Advisory Team (ANSAT) is a collaborative group of multidisciplinary experts, led by Dr. Johanna Mejia-Fava, who will work alongside Animal Necessity to establish a unique knowledge sharing platform for veterinary communities across the world. ANSAT includes scientists, board certified veterinary specialists, DVMs, curators and trainers who share an interest in complementary veterinary medicine and are interested in promoting its advancement.

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OUR CIRCLE OF CAREProven safe and eective for human consumption Trusted by zoo and aquarium veterinarians around the world

Our products come from the purest natural materials

Scientically formulated for use in companion animal care

Our circle of care began with establishing a standard of quality for natural human products, a standard that we have brought to zoo, aquarium and companion animal medicine.5

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INFOrMATIONAnimal Necessity is committed to providing high quality customer service and a variety of easy ordering options. Orders can be placed using any of the following methods: Online: www.animalnecessity.com Phone: 1-800-721-1310 Fax: 212-202-7818 Email: customer.service@animal-necessity.com Hours of Operation: Monday Friday, 10 a.m. 6 p.m. EST Orders usually ship within 24 hours

OrDerINg

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PROPRIETARY BLENDS LisT OF PrODucTsImuno-2865 - Immune Adjunctive Support Serenin Vet - Natural Anti-anxiety & Calming Aid Eye-SEA - Large Animal Vision Supplement Ocu-GLO Rx - Canine Vision Support SHaNa Vet (CAPSULES & CREAM) - Skin and Coat SupportTM TM TM TM TM

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I muno -2865Helps maintain healthy gastrointestinal function enhances immune system activity

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enhances immune system response and the bodys first line and second line defense and other important funtional components of the immune system

Product DescriptionImuno-2865 (NatramuneTM) is a naturally obtained hemicellulose (high molecular weight polysaccharide complex) and fatty acid mixture extracted from natural sources (gramineae, Poaceae, Dioscoreaceae family of plants and/or several species of mushrrooms).

IngredientsN UTRITION PDS-2865 Proprietary Blend Polysaccharide Complex extract rice Flour rice Bran Microcrystalline cellulose grapeseed extract A MOUNT P ER S ERVING

1000 mg

Published Studies1. The Affects of Natramune (PDS-2865), A New Immunostimulator Supplement on Different Cetacean Species; Tursiops truncatus, Lagenorhynchus obliquidens, and Orcinus orca. Proceedings of the IAAAM, 38, 44-45.TM

Serving Size: 2 capsules

Baseline DosagesUnder 20 lbs 20-50 lbs 50-100 lbs 100-150 lbs 150-200 lbs 200-400 lbs 500 lbs + capsule 1 capsule 2 capsules 3 capsules 4 capsules 5 capsules Contact Us

2. rodriguez M, Mejia J, Blanchard M, Stott J, Pestano N, Perez P. (2008). NatramuneTM (PDS-2865), An Immunostimulator Supplement in Cetaceans. Proceedings of the IAAAM, 39, 26 3. Chavoustie S, Perez P, Fletcher M, Maher K, Mitrani a, Thomas r. Pilot study: effect of IN-2865TM on natural killer cell cytotoxicity. Journal on Nutraceuticals and Nutrition, Volume 6, No. 2: pp.3942, 2003. 4. Weeks BS, et al. The hemicellulose preparation, Natramune (PDS-2865), increases macrophage phagocytosis and nitric oxide production and increases circulating human lymphocytes levels. Med Sci Monit. 2009;15(2):Br43-46. 5. Weeks BS, et al. Natramune and PureWay-C reduce xenobiotic-induced human T-cell alpha5beta1 integrin-mediated adhesion to fibronectin. Med Sci Monit. 2008;14(12):Br279-85.

The above doses are for preventative health. For specific diseases, please contact Animal Necessity for a free consultation.

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S erenIn V eTNatural calming and anti-anxiety support

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Anti-anxiety support for aggression and other anxiety related conditions or behavior problems.

Product DescriptionSerenin VetTM is a unique combination of plant ingredients, amino acids, fatty lipids, vitamins and minerals. Some of these ingredients have demonstrated the ability to raise serotonin levels in the brain, which may lead to relief from depression, anxiety, and aggressive or nervous behavior.

List of IngredientsN UTRITION PDS-2865 Proprietary Blend (Polysaccharide complex extract, rice flour, rice bran, microcrystalline cellulose, cyclodextrin) Vitamin B-6 (as pyridoxine HCl) Folate (as folic acid) Vitamin B-12 (as cyanocobalamin) Magnesium (as magnesium oxide) Selenium (as selenium amino acid chelate) 5-HTP (L-5-hydroxy-tryptophan (glyffonia simplicifolia) (seed) DL- Phenylananine eleuthero powder (eleutherococcus senticosus)(rhizome) Inositol L-Tyrosine St. John's Wort extract (Hypericum perforatum)(flower heads)(std. for 0.3% Hypericin (1.8 mg)) Passion flower extract (Passiflora incarnata) (aerial parts)(std. for >3.5% flavonoids as Isovetexin (1.75 mg)) Serving Size: 2 capsules 100mg 10mg 600mg 40 mg 70 mg A MOUNT P ER S ERVING

100 mg25 mg 400 mcg 200 mcg 100 mg 70 mcg 25 mg

Baseline DosagesUnder 50 lbs 50-100 lbs 100-200 lbs 200-300 lbs 300-500 lbs 500 lbs + capsule 1 capsule 2 capsules 3 capsules 4 capsules Contact Us

50 mg

Dose may increase depending on severity of aggression and anxiety, please contact Animal Necessity for dosing. Do not use Serenin if animal is on a monoamine oxidase inhibitor (MAOI) or an antidepressant.

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Eye-SEA

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Specifically formulated to promote ocular health in large animals Assists with recovery after cataract surgery and other ocular diseases Formulated in collaboration with a board certified veterinary ophthalmologist See study: Colitz C, Saville W, renner M, McBain J, reidarson T, Schmitt T, Nolan e, Dugan S, Knightly F, rodriguez M, Mejia-Fava J, Osborn S, Clough P, Collins S, Osborn B, Terrell K, risk factors associated with cataracts and lens luxations in captive pinnipeds in the United States and Bahamas. JAVMA2010;Vol237,No.4:429-436

Product Descriptioneye-SeA is a unique and ideally chosen blend of antioxidants that support all structures of the eye in specific and nonspecific ways. Some of the ingredients have also been shown to be beneficial against cancer.TM

List of IngredientsN UTRITIONImuno-2865TM, Omega-3 supplying (ePA/DHA), Lycopene from Tomato extract, Sylimarin 80% extract

A MOUNT P ER S ERVING 125 mg

Proprietary Blend

grapeseed extract 95% Pinebark extract Lutein elemental Zeathanthin elemental Zinc (as Zinc Oxide) Alpha Lipoic Acid Biberry extract Vitamin e Folic Acid (as Folate) Coenzyme Q10

150 mg 30 mg 20 mg 10 mg 4 mg 100 mg 15 mg 50 IU 50 mcg 30 mg

Serving Size: 1 capsule

DosagesUnder 60 lbs 60-300 lbs 300 lbs+ 1 capsule 3 capsules 6 capsules

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Ocu-GLO Rx

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Specifically formulated to support canine eyes in health and disease Includes grapeseed extract, Lutein, and Omega-3 Fatty Acids Formulated by board certified veterinary ophthalmologists

Product DescriptionOcu-gLO rx is a blend of 12 different antioxidants that complement traditional therapy, and are formulated to protect vital cells in the eye at the DNA and protein levels from oxidative damage occurring with ocular conditions including PrA, Senile retinal Degeneration, early Diabetic and other types of Secondary Cataracts, pre and post-operative Cataract Surgery, Uveitis, glaucoma, Optic Neuritis and Dry eye. Formulated by Dr. Carmen Colitz, Dr. Terri McCalla and Debby Smith of Animal Health Quest.

List of IngredientsN UTRITION gLO rxTM Proprietary Blend (grape Seed extract 95%, Lutein 20%, Omega-3 55%) Vitamin C (as Ascorbic Acid) Vitamin e (as d-Alpha Tocopheryl) Vitamin B-1 (as Thiamine HCI) Vitamin B-3 (as Niacin) Vitamin B-6 (as Pyridoxine HCI) Folate (as Folic Acid) Vitamin B-12 (as Cyanocobalamin) Biotin Pantothenic Acid (as d-Calcium Pantothenate) Zinc (as Zinc Oxide) Alpha Lipoic Acid Coenzyme Q10 (Ubiquinone) Lycopene from Tomato extract green Tea extract 40% eCgC Other Ingredients: gelatin, glycerin, Beeswax, Lecithin, Soybean Oil and Liver extractA MOUNT PER AMOUNT PER S MALL D OG MEDIUM/LARGE G ELCAP DOG GELCAP

175 mg 50 mg 25 IU 0.1 mg 1.2 mg 0.1 mg 20 mcg 2.5 mcg 10 mcg 1 mg 3 mg 13 mg 13 mg 1 mg 20 mg

351 mg 100 mg 50 IU 0.2 mg 2.4 mg 0.2 mg 40 mcg 5 mcg 20 mcg 2 mg 5 mg 25 mg 25 mg 2 mg 40 mg

Dosages10 lbs and under 10-30 lbs 30-60 lbs 60-100 lbs + 1 gelcap for Small Dogs 1 gelcap for M/L Dogs 2 gelcaps for M/L Dogs 3 gelcaps for M/L Dogs

Serving Size: 1 gelcap

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SHaNa Vet (CAPSULES)exhibits antiviral activity against several lipid enveloped viruses including Herpes Simplex Helps enhance antiviral, anti-inflammatory and anti-fungal activity Decreases viral replication, shortens healing time and duration of symptoms Helps to protect the superficial layer of the epidermis, fur, and nails to aid in prevention of viral and fungal diseases.

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Product DescriptionSHaNa Vet is a blend of natural phytowax and botanical extracts with amino acids and vitamins consistently found in healthy skin, fur and keratin. Oral supplementation and topical administration of SHaNa Vet has been shown to relieve scaling, redness, itching, fissures, vesicles, and as effective support for fungal disease fee skin.TM

List of IngredientsN UTRITION A MOUNT P ER S ERVING

TopicalPlus Proprietary Blend 3% blend (Docosanol and Triacontanol) Vitamin A Vitamin D

500 mg

2000 IU 100 IU

Baseline DosagesUnder 50 lbs 50-100 lbs 100-200 lbs 200-500 lbs 500 lbs + capsule 2 capsules 4 capsules 6 capsules Contact Us

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SHaNa Vet (CREAM)Published Studies1. Marcelletti et al., 1996. J.F. Marcelletti, P. Lusso and D.H. Katz, n-Docosanol inhibits in vitro replication of HIV and other retroviruses. AIDS res. Hum. retrovir. 12 (1996), ppp. 71-74. 2. McBride, P.T., Clark, L and Krueger g.g. evaluation of triacontanol-containing compounds as anti-inflammatory agents using guinea pig models. J Invest Dermatol. 89 (1987), pp. 380-3.

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SHANA cream 8/11/09 (8/11/09) 9/2/09 Before

The most important ingredients in SHaNa VetTM includes Docosanol and Tricontanol, which have been shown to have anti-viral and anti-inflammatory activities. Clinical studies have shown that Docosanol inhibits infusion between envelope viruses, such as herpes simplex, and the host cells, thus blocking entry and replication. Triacontanol (TrIA) has been known to exhibit antiinflammatory action is animals and this antiinflammatory effect of TrIA might be mediated through inhibition of lipid peroxidation. Since LOX inhibitors have been extensively used as their therapeutic agents, TrIA, being a natural compound has been suggested to be an effective anti-inflammatory drug.

SHANA cream 8/11/09 9/2/09After (9/2/09)

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SPECIALTY BLENDS

MULTI-34 VITA-13 ARTICHOKE & MILK THISTLE DIGESTIN VET ALPHA LIPOIC ACID NEUROPLEX

PROTOCOL BASED APPROACHAnimal Necessity launched in 2006 with the mission to set the standard for natural animal healthcare, and in 2012 we continue to stay true to that focus. Our staff veterinarians and Scientific Advisory Team members remain dedicated to developing the most comprehensive and practical protocols for our clients. We believe that the best quality healthcare is only achieved by a holistic approach that takes more than simply adding supplements to an animals diet. For that reason we strive to meet the individual needs of every client and offer our nutritional consultations free of charge. For testimonials or examples of protocols in use, please visit our website at: www.animalnecessity.com The baseline dosages in this catalog are calculated by animal weight and can be dispensed to most species as a preventative or maintenance dose. For individual cases or specific disease support questions, please set up a consultation with one of team members by emailing us at: info@animal-necessity.com.17

m ulTI -34Product Description

Suggested as a daily multi-vitamin in combination with Vita-13 and B-1 Suggested as a daily multi-vitamin with ocular support when in combination with eye-Sea and B-1 Specifically formulated for marine mammals

Multi- 34 is formulated specifically for marine mammals providing 34 different ingredients of minerals and vitamins. This multi-vitamin helps in the production and maintenance of new cells, which is important during pregnancy for fetal development and function. The main components of this mixture have been utilized at a reproductively, successful marine facility for the past two decades. Inositol and taurine have been added to help with brain and fetal development.

List of IngredientsN UTRITIONVitamin A (acetate and beta-carotene) Vitamin C (ascorbic acid) Vitamin D (cholecalciferol) Vitamin e (di-alpha tocophyeryl acetate) Vitamin K (phytonadione) Thiamim (Vitamin B-1) (Thiamin Montriate) riboflavin (Vitamin B-2) Niacin (Vitamin B-3) (niacinamide) Vitamin B-6 (pyridoxine HCI) Folate (Folic Acid) Vitamin B-12 (cyanocobalamin) Biotin Pantothenic Acid (d-calcium pantothenate) Calcium (dicalcium phosphate) Iron (ferrous fumarate) Phosphorous (dicalcium phosphate) Iodine (potassium iodide) Magnesium (magnesium oxide) Zinc (zinc oxide) Selenium (sodium selenate) Copper (cupric sulfate) Manganese (maganese sulfate) Chromium (chromium aspartate) Molybdenum (sodium molybdate) Chloride (potassium chloride) Potassium (potassium chloride) Boron (boron citrate/aspartate/glycinate complex) Choline (choline bitatrate) Inositol Nickel (nickelous sulfate) Silicon (silicon dioxide) Taurine Tin (stannous chloride) Vanadium (as sodium metavanadate)

A MOUNT P ER S ERVING5000 IU 90 mg 400 IU 60 IU 28 mcg 3 mg 3.4 mg 20 mg 6 mg 400 mcg 12 mcg 30 mcg 10 mg 40 mg 18 mg 31 mg 150 mg 100 mg 15 mg 70 mcg 2 mg 2 mg 50 mcg 75 mcg 7.5 mg 7.5 mg 150 mcg 10 mg 10 mg 5 mg 2 mg 30 mcg 10 mcg 10 mcg

Baseline DosagesPinniped Dolphin 1 tablet 2 tablets

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V ITa -13

Suggested as a daily multi-vitamin in combination with Multi-34 and B-1 Specifically formulated for marine mammals

Product DescriptionVita-13 formulation provides a beneficial amount of B-complex vitamins and anti-oxidant support. This mixture have been utilized at a reproductively, successful marine facility for the past two decades. VIta-13 has been used in combination with eye Sea, B-1, and Vitamin e as a daily vitamin intake in marine animals with hemochromatosis.

List of IngredientsN UTRITION Vitamin C (ascorbic acid) Vitamin e (di-alpha tocopheryl acetate) Thiamine (Vitamin B-1) (thiamine monoitrate) riboflavin (Vitamin B-2) Niacin (Vitamin B-3) (niacinamide) Vitamin B-6 (pyridoxine HCl) Folate (folic acid) Vitamin B-12 (cyanocobalamin) Biotin Pantothenic acid (d-calcium pantothenate) Zinc (zinc sulfate) Copper (copper amino acid chelate) 10 mg 1000 mg 5 mg 400 mcg 12 mcg 45 mcg 20 mg 24 mg 3 mg A MOUNT P ER S ERVING 500 mg 30 IU 15 mg

Baseline DosagesPinniped Dolphin 2 tablets 3 tablets

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arTICHoKe & mIlK THISTleNatural support for optimal liver health Suggested use with Digestin-Vet to help improve digestion Aids in liver, gallbladder, and kidney function Suggested use with Alpha Lipoic Acid for maximum antioxidant hepatic support

Product DescriptionArtichoke & Milk Thistle is a high potency herbal formula that is formulated for optimal liver health. Artichoke is a flower extract that helps improve digestion and aids in liver, gallbladder, and diuretic kidney function. Milk Thistle contains 80% of silymarin, an important compound that nourishes the liver and helps protect it from cellular damage by providing antioxidant properties.

List of IngredientsN UTRITIONArtichoke flower extract (standardized for minimum 2.5% caffeyiquinic acids (6.25 mg) Milk thistle extract (Silybum marianus) (seeds, ground) Standardized for 80% silymarin (140 mg)

Baseline DosagesA MOUNT P ER S ERVINGUnder 50 lbs 50-100 lbs 100-200 lbs 200-500 lbs 500 lbs + 1 tablet 2 tablets 4 tablets 6 tablets Contact Us

500 mg 200 mg

Promotes digestive health

D IgeSTIn V eT

Provides probiotics which helps maintain beneficial bacterial flora of the digestive tract Aids in the production of red blood cells Appetite stimulant Suggested use with Artichoke and Milk Thistle for liver and digestive support

List of IngredientsPlease check our website for full list of ingredients.www.animalnecessity.com

Product DescriptionDigestin-Vet is an advanced formula that incorporates herbal ingredients, high potency digestive enzymes, and essential nutrients that help support digestion. This supplement contains lactobacillus acidophilus, providing 1 billion active organisms at time of manufacture, which helps maintain and restore normal bacterial balance in the gastrointestinal tract. Patients with inflammatory bowl disease, pancreatic insuffciency, and chronic diarrhea will find this formula a good complement to their therapeutic programs. This supplement has been administered to animals with digestive problems where digestive enzymes may be lacking or not properly functioning therefore causing problems in assimilation.

Baseline DosagesUnder 100 lbs 100-200 lbs 200-400 lbs 400 lbs + 1 tablet 3 tablets 4 tablets Contact Us

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alpHa lIpoIC aCIDProduct Description

Protects the body against cell damage in conditions of oxidative stress Boosts glutathione - increases the body's production of glutathione, which helps dissolve toxic substances in the liver Supports normal liver enzyme levels Promotes normal glucose metabolism Suggested use with Artichoke and Milk Thistle for hepatic support

Alpha lipoic (ALA) is a fatty acid that acts as a powerful water and fat-soluble antioxidant found in the body in trace amounts. ALA increases the bodys production of glutathione, the bodys most important endogenous antioxidant. ALA is known for its ability to help neutralize cell damaging free radicals and helps dissolve toxic substances in the liver.(1) Imbalance of the glutathione redox cycle contributes to cataractogenesis and ALA has been shown to protect lenses from oxidative stress that causes cataract.(2) This universal antioxidant helps to benefit diabetic canine patients as it promotes normal insulin sensitivity and glucose metabolism, though actual levels of insulin and glucose may not change.(3) Note: It is not safe in cats at a dose higher than 30 mg/day. 1, 2, 3 Please visit www.animalnecessity.com for references

List of IngredientsN UTRITION Alpha Lipoic Acid AMOUNT PER SERVING

Baseline DosagesUnder 50 lbs 50-100 lbs 100-200 lbs 200-300 lbs 300-500 lbs 500 lbs +

1 capsule 2 capsules 3 capsules 4 capsules 6 capsules Contact Us

50 mg

enhance nerve regeneration Helps to prevent neurodegeneration Helps to reduce nerve damage upon stress or injury

n europlex

Product DescriptionThe supplement Neuro-plex combines both: Neuroprevin and PolicosanolPlus which has been shown to enhance nerve formation and then promote the maintenance of these nerves (1). evidence supports its use as a functional ingredient for nerve regeneration as well as neuroprotection from the effects of environmental pollutants and aging. If this supplement is used as part of a daily dietary routine, it can serve as a prophylactic against the onset of neurodegenerative diseases. 1 Weeks B, Perez P. PolicosanolPlus and Neuroprevin enhance Neurite regeneration and Prevent Neurite Degeneration: A Dietary Supplement for Nerve repair, Prevention, and reduction of Neurodegenerative Disorders. Journal on Nutraceuticals and Nutrition, Volume 6, No. 2: p. 24, 2006.

List of IngredientsN UTRITION Neuro-plex proprietary blend riboflavin (Vitamin B2) Folate (as folic acid) AMOUNT PER SERVING

Baseline DosagesUnder 100 lbs 100-200 lbs 200-300 lbs 300-500 lbs 500 lbs + 1 capsule 2 capsules 3 capsules 4 capsules Contact Us

315 mg 1 mg 400 mcg

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o THer T op p roDuCTSJOINT gUArD OMegA-3 VINPOCeTINe PINeBArK eXTrACT WITH PUreWAy C OXy-IN SPIrULINA VITAMIN B-1 (THIAMIN) VITAMIN D3 VITAMIN e

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ANIMAL NeCeSSITy, LLC330W 38th Street, Suite # 801 New york, Ny 10018 Toll Free: 1-800-721-1310 email: info@animal-necessity.com www.animal-necessity.com