Dr Andrew S Wells

Publications, Patents, Invited Presentations etc.

May 2016

Publications

88) Rebecca E. Meadows, Keith R. Mulholland, Martin Schürmann, Michael Golden, Hans Kierkels,

Elise Meulenbroeks, Daniel Mink, Oliver May, Christopher Squire, Harrie Straatman andAndrew S.

Wells Efficient Synthesis of (S)-1-(5-Fluoropyrimidin-2-yl)ethylamine using an ω-Transaminase

Biocatalyst in a Two-Phase System Practical Methods for Biocatalysis and Biotransformations 3,

Wiley 2016

87). Biocatalysis for Medical Chemistry Green and Sustainable Medicinal Chemistry: Methods,

Tools and Strategies for the 21st Century Pharmaceutical Industry Series: RSC Green Chemistry 2016.

86). Inês P. Rosinha, Søren Heintz, Ulrich Krühne, Krist V. Gernaey, Patrick Adlercreutz, Andy S.

Wells and John M. Woodley ‘Considerations for selection of organic solvents applied to biphasic

systems for in-situ product recovery and downstream processing in bioprocesses’ Green

Chemistry submitted for publication.

85). Andrew S Wells, John W Wong, Peter C Michels, Dave Entwistle, Keith Fandrick, Gregory L

Finch, Animesh Goswami, Heewon Lee, Stefan Mix, Thomas S. Moody, Long Pang, Robert K

Sato, Nicholas J Turner, and Timothy J Watson. ‘Case Studies illustrating a science and risk-

based approach to ensuring drug quality when using enzymes in the manufacture of Active

Pharmaceuticals Ingredients for oral dosage form.’ Organic Process Research and Development,

2016, 2016, 20 (3), pp 594–601

84). D. Lathbury and A. Wells ‘Oxidation and Oxidative Reactions’ Organic Process Research and

Development, 2015 special edition on oxidation Org. Process Res. Dev. 2015, 19, 1536−1536.

83). Denis Prat, Andy Wells, John Hayler, Helen Sneddon, C. Robert Mc Elroy, Sarah Abou-Shehadad and Peter J. Dunn CHEM21 Selection Guide of Classical – and Less Classical – Solvents. Green Chemistry, 2016, 18, 288-296.

82). Chungang Gu,Richard J. Lewis, Andrew Wells, Per H. Svensson, Vinayak P. Hosagrahara,

Eskil Johnsson, and Gösta Hallström "Lipid peroxide mediated oxidative rearrangement of the

pyrazinone carboxamide core of neutrophil elastase inhibitor AZD9819 in blood plasma

samples.’ Drug Metabolism and Disposition, 2015, Oct;43(10):1441-1449.

81). ‘Some Reflections on Solvent Selection’ ACS Nexus blog Jan 2015

https://communities.acs.org/community/science/sustainability/green-chemistry-nexus-

blog/blog/2015/01/26/some-reflections-on-solvent-selection

80). ‘Meet the Green Team’ – The Medicine Maker, March 11th, 2015 Issue 0215, 2015

https://themedicinemaker.com/issues/a-better-pill-to-swallow/meet-the-green-team/

79). Christopher P. Ashcroft, Peter J. Dunn, John D. Hayler, Andrew S. Wells ‘Survey of Solvent

Usage in Papers Published in Organic Process Research and Development 1997-2012.’ Organic

Process Research and Development, 2015, 19, 740-747.

78). Denis Prat, John Hayler and A Wells ‘A Survey of Solvent Selection Guides’ Green Chemistry–

2014,16, 4546-4551.

77). K. Deplanche, J. A. Bennett, I.P.Mikheenko, J. Omajali, A. S. Wells, R. E. Meadows, J. Wood

and L. E. Macaskie Catalytic activity of biomass-supported Pd nanoparticles: influence of the

biological component in catalytic efficacy and potential application in ‘green’ synthesis of fine

chemicals and pharmaceuticals -Applied Catalysis B- Environmental, 2014, 147, 651-665.

76). N. J. Turner and Andy Wells ‘The Enzyme Spring: Biocatalysis at its Best’ ChemCatChem,

2014, 6, 900.

75). Andy Wells and Hans-Peter Meyer ‘Biocatalysis as a Strategic Green Technology for the

Chemical Industry’ ChemCatChem, 2014, 6, 918.

74). Julia A. Griffen, Jenifer C. White,

Gabriele Kociok-Köhn,

Matthew D. Lloyd,

Andrew Wells,

Tom

C. Arnot and Simon E. Lewis New Aminocyclitols with Quaternary Stereocenters via Acylnitroso

Cycloaddition with an ipso, ortho-Arene Dihydrodiol Tetrahedron, 2013, 69, 5989–5997.

73). Rebecca E. Meadows, Keith R. Mulholland, Martin. Schürmann, Michael Golden, Hans

Kierkels, Oliver May, Elizabeth Meulenbroeks, Daniel Mink, Oliver May , Christopher Squire , Hans

Straatman, Andrew S.Wells Efficient Synthesis of (S)-1-(5-Fluoropyrimidin-2-yl)ethylamine using

an ω-Transaminase Biocatalyst in a Two-Phase System Organic Process Research and

Development, 2013, 17, 1117–1122

72). Lianne Frodsham, Michael Golden, Susan Hard, Martin N. Kenworthy, David J. Klauber, Kevin

Leslie,Claire Macleod, Rebecca E. Meadows, Keith R. Mulholland, Julie Reilly, Christopher Squire,

Simone Tomasi, Denise Watt, and Andrew S. Wells ‘Use of ω‑Transaminase Enzyme Chemistry

in the Synthesis of a JAK2 Kinase Inhibitor Organic Process Research and Development, 2013, 17,

1123–1130

71). Andrew S. Wells, Gregory L. Finch, Peter C. Michels, and John W. Wong ‘Use of Enzymes in

the Manufacture of Active Pharmaceutical Ingredients—A Science and Safety-Based Approach

To Ensure Patient Safety and Drug Quality’ Organic Process Research and Development, 2012, 16,

1986.

70). L. Amarnath, Ian Andrews, Rakeshwar Bandichhor, Apurba Bhattacharya, Peter Dunn, John

Hayler, William Hinkley, Nicole Holub, David Hughes, Luke Humphreys, Bernard Kaptein, Hare

Krishnen, Kurt Lorenz, SujuMathew, G. Nagaraju, Thomas Rammeloo, Paul Richardson, Lijun Wang,

Andrew Wells, Timothy White Green Chemistry Articles of Interest to the Pharmaceutical

Industry’ Organic Process Research and Development, 2012, 16, 535.

69). Mark Dow, Rhona Sinclar, Rebecca Meadows, Andrew Wells Dynamic kinetic resolution of α-

halo esters with hydrolytic enzymes and sec-amine bases Practical Methods for Biocatalysis and

Biotransformation Volume 2, Wiley 2012.

68). Neil Barnwell and Andrew Wells Asymmetric synthesis of quaternary amino acids from

simple bis nitriles using a dual nitrile hydratase/amidase biocatalyzed reaction ‘ Practical

Methods for Biocatalysis and Biotransformation Volume 2, Wiley 2012.

67). J. Adams, I. Archer, D. Auriol, M. Avi, K. Baldenius, C. Branneby, A.Collis, B. Dumas, T.

Eckrich, I. Fotheringham, S. Hallon, M. Hassen, K. Holt-Tiffin, R. Howard, G. Huisman, H. Iding, M.

Kittelmann, K. Laumen, E. Kupfer, F. Lefevre, S. Luetz, V. Martin, H-P. Myer, T. Moody, A. Osorio-

Lozada, K. Robbins, P. Sutton, M. Truppo, A. Wells, J. Wong, B. Wirz ‘Biocatalysis in the Fine

Chemical and Pharmaceutical Industries: An Industrial Perspective’ Practical Methods for

Biocatalysis and Biotransformation Volume 2, Wiley 2012.

66). Ian Andrews , Peter Dunn , John Hayler , Bill Hinkley , David Hughes , Berard Kaptein , Kurt

Lorenz , Suju Mathew, , Thomas Rammeloo , Lijun Wang , Andrew Wells , Timothy D. White

‘Green Chemistry Articles of Interest to the Pharmaceutical Industry’ Organic Process Research

and Development, 2011, 15, 748.

65). Ian Andrews, Peter Dunn, John Hayler, Bill Hinkley, David Hughes, Bernard Kaptein, Kurt

Lorenz, Suju Mathew, Thomas Rammeloo, Lijun Wang, Andrew Wells, and Timothy Donald White

Green Chemistry Articles of Interest to the Pharmaceutical Industry’ Organic Process Research

and Development, 2011, 15, 22.

64). Ian Andrews, Jian Cui, Leo Dudin, Peter Dunn, John Hayler, Bill Hinkley, David Hughes,

Bernard Kaptein, Kurt Lorenz, Suju Mathew, Thomas Rammeloo, Lijun Wang, Andrew Wells,

Timothy Donald White Green Chemistry Articles of Interest to the Pharmaceutical Industry’

Organic Process Research and Development, 2010, 14, 770.

63). Concepción Jiménez-González, Peter Poechlauer, Rinus Broxterman, Bing-Shiou Yang, David

am Ende, James Baird, Carl Bertsch, Robert E. Hannah, Phil Dell'Orco, Henk Noorman, Sandy Yee,

Raf Reintjens, Andrew Wells, Viviane Massonneau, Gjalt Hiusman and John Hayler ‘Key Green

Engineering Research Areas for Sustainable Manufacturing —A perspective from

pharmaceutical and fine chemicals manufacturers’ Organic Process Research and Development,

2011, 15, 900.45.

62). ‘On the Perils of Unexpected Silane Generation’ Organic Process Research and Development,

2010, 14, 484.

61). ‘Industrial Applications of BioCatalysis: An Overview’ Comprehensive Chirality, Volume 9,

pp. 253-287. Amsterdam: Elsevier, 2012.

60). ‘The use of Continuous Processing to Make AZD4407 Intermediates’, Pharmaceutical Process

Chemistry, Pub. Wiley 2010.

59). ‘Biocatalytic Routes to the Large Scale Synthesis of Lotrafiban’, Asymmetric Catalysis on

Industrial Scale 2nd

ed. Pub. Wiley 2010.

58). Lee Proctor, Peter Dunn, Joel Hawkins, Andy Wells, and Mike Williams ‘Continuous

Processing in the Pharmaceutical Industry’ Chapter 11, Green Chemistry in the Pharmaceutical

Industry, Pub. Wiley, 2010.

57). Peter Dunn, Andy Wells, and Mike Williams’ Future Trends’ Chapter 16, Green Chemistry in

the Pharmaceutical Industry, Pub. Wiley, 2010.

56). Geoffrey R, Akien, Jean-Christophe Legeay, Andrew Wells,

and Martyn Poliakoff ‘The

Continuous Catalytic Debenzylation of p-dibenzyloxybenzene with H2 in THF Expanded with

High Pressure CO2 ‘ Organic Process Research and Development, 2010, 14, 1201.

54). Karim Engelmark, Cassimjee, Cecilia Branneby,

Vahak Abedi,

Andrew Wells, Per Berglund

‘Transaminations with isopropyl amine: Equilibrium displacement with yeast alcohol

dehydrogenase coupled to in situ cofactor regeneration’ Chemical Communications , 2010, 5569.

53). Ian Andrews, Jian Cui, Jimmy DaSilva, Leo Dudin, Peter Dunn, John Hayler, Bill Hinkley,

David Hughes, Bernard Kaptein, Kurt Lorenz, Suju Mathew, Thomas Rammeloo, Lijun Wang,

Andrew Wells, Timothy White, and Fuyao Zhang ‘Green Chemistry Articles of Interest to the

Pharmaceutical Industry’ Organic Process Research and Development, 2010, 14, 19.

52). Ian Andrews, Jian Cui, Jimmy DaSilva, Leo Dudin, Peter Dunn, John Hayler, Bill Hinkley, David

Hughes, Bernard Kaptein, Stanley Kolis, Kurt Lorenz, Suju Mathew, Thomas Rammeloo, Lijun

Wang, Andrew Wells, Timothy White, Chaoyu Xie, Fuyao Zhang ‘Green Chemistry Articles of

Interest to the Pharmaceutical Industry’ Organic Process Research and Development, 2009, 13,

397.

51). ‘The Green Movement-Rethinking Chemistry’ Pharmavoice, Sept 2008

50). S. Challenger, L. Dudin, J. DaSilva, P. Dunn, T. Govaerts, J. Hayler, B. Hinkley, Y. Houpis, T.

Hunter, L. Jellet, J. L. Leazer, K. Lorenz, S. Mathew, T. Rammeloo, R. Sudini, Z. Wan, C. Welch,

A. Wells, J. Vance, C. Xie, F. Zhang ‘Green Chemistry Highlights’ Organic Process Research and

Development, 2008, 12, 807.

49). Peter Clark, Martyn Poliakoff and Andrew Wells, ‘Continuous Flow Hydrogenation of

Pharmaceutical Intermediate, [4-(3,4-dichlorophenyl)-3,4-dihydro-2H-naphthalenyidene methyl

amine, in Supercritical Carbon Dioxide’ Advances in Synthesis and Catalysis, 2007, 439, 2655.

48). Charlotte Wiles, Gillian M. Greenway, Paul Watts, Andy Wells, Linda L. Woodcock and Steve

Eyley ‘Optimised Enzymatic Synthesis of a Series of Alkyl Esters using Novozyme 435 in a

Packed-Bed, Miniaturised, Continuous Flow Reactor’ Biocatalysis & Biotransformation, 2008, 26,

501.

47). David C. Constable, Peter J. Dunn, John Hayler, John Leazer, Russell J. Linderman, Kurt Lorenz,

Julie Manley Bruce Pearlman, Andrew Wells, Aleksey Zaks, Tony Y. Zhang, ‘Key Green

Chemistry Research Areas – A Perspective From Pharmaceutical Manufacturers’ Green

Chemistry, 2007, 9, 411. 298.

46). D. Blackmond, A. Armstrong, V. Coombe, A. Wells ‘Water in Organocatalytic processes:

Debunking the Myths’ Angew. Chem. Int. Ed. 2007, 46, 3798.

45). T.S.C. Eve, N. Turner and Andrew Wells ‘Enantioselective Oxidation of O-methyl – N-

Hydroxylamines using Monoamine Oxidase N as a Catalyst’ Chemical Communications,

2007,1530.

44). ‘Enzymes at Work’ Chemical & Engineering News, 2006, 84, (33)

43). ‘Biocatalysis for Greener Transformations’ Speciality Chemicals, 2006, 26, (10), p24. 15.

42). Vyv Coombe and Andrew Wells ‘On the Freshwater Ecotoxicity and Biodegredation of some

Common Ionic Liquids’, Organic Process Research and Development, 2006, 10, 794.

41). Neil Barnwell, Lal Cheema, Janette Cherryman, JérÔme Dubiez, Garnet Howells

and Andrew Wells ‘Selective Lipase-Catalysed Hydrolysis of a 1,2-Diester in the Development of

a New Route to AZD2563 DSP’ Organic Process Research and Development, 2006, 10, 644.

40). ‘What’s in a Biocatalyst?’ Organic Process Research and Development, 2006, 10, 678.

39). Andy Wells, Tom Eve and Maira Teria ‘ Green Oxidations using Laccase –Mediator Systems’

Biochemical Society Transactions, 2006, 34, 2, 304.

38). Richard J. Atkins, Adam Banks, Richard K. Bellingham, Gary F. Breen, John S. Carey, Stephen

K. Etridge, Jerome F. Hayes, Nigel Hussain, David O. Morgan, Paul Oxley, Stephen C. Passey,

Timothy C. Walsgrove, and Andrew S. Wells , ‘The Development of a Manufacturing Route for

the GPIIb/IIIa Receptor Antagonist SB-214857-A. Part 2: Conversion of the Key Intermediate

SB-235349 to SB-214857-A’ Organic Process Research and Development, 2003, 7, 663.

37). Richard J. Atkins, Gary F. Breen, David O. Morgan, Andrew C. Share, Stephen A. C. Smith,

Timothy C. Walsgrove and Andrew S. Wells, ‘Development of an Efficient Manufacturing Route

to Methyl 2,3,4,5-tetrahydro-4-methyl-3-oxo-1H-benzodiazepine-2-acetate SB-235349, a Key

Intermediate in the Synthesis of Lotrafiban’, Organic Process Research and Development, 2003, 7,

655.

36). M. Alston, A. Willetts and A. Wells ‘Polymer-Supported Catalase - the Green Approach to

the Removal of Hydrogen Peroxide from Reaction Mixtures’ Organic Process and Development,

2002, 6, 505.

35). J-P Baptiste, J. Hayes, H. Seldrake, P. Sheldrake, and A .S. Wells ‘Synthesis of SB 214857

using Copper-Catalysed amination of aryl bromides with L-Aspartic Acid’ Syn. Letts., 2001,

1423.

34). L .Powell, T. Walsgrove and A. Wells, ‘A Practical and Robust Process to Produce SB-

214857 'Lotrafiban ' ((2S)-7-(4,4'-Bipiperidinylcarbonyl)-2,3,4,5-tetrahydro-4-methyl-3-oxo-1H-

1,4-benzodiazepine-2-acetic acid) Utilising an Enzymic Resolution as the Final Step’ Organic

Process Research and Development, 2002, 6, 488.

33). Ian Andrews, Richard Atkins, Richard F Bellingham, Gary Breen, John S Cary, Stephen K.

Smith, Jerome F. Hayes, Nigel Hussain, David O. Morgan, Andrew Share, Stephen Smith, Timothy C.

Walsgrove, Andrew Wells, ‘A New Synthesis of the GPIIb/IIIa Receptor Antagonist SB 214857-

A’ Tet. Letts., 2001, 42, 4915.

32). E. Le Carre, N. Lewis, C. Ribas and A. Wells, ‘Convenient Preparation of Functionalised

Polymer-based Resins via an Economical Preparation of Chloromethylated Polystyrene Resins

(Merrifield type)’ Organic Process Research and Development, 2000, 4, 606.

31). N. Lewis, C. Ribas and A. Wells, ‘A Highly Efficient Preparation of Methacrylate Esters

using Novel Solid Phase Titanium -based Transesterification Catalysts’ Syn.Lett., 1999, 957.

30). S. Etridge, J. Hayes, T. Walsgrove and A. Wells, ‘A New and Convergent Synthesis of (2S)-7-

(4,4'-bipiperidinylcarbonyl)-2,3,4,5-tetrahydro-4-methyl-3-oxo-1H-1,4-Benzodiazepine-2-Acetic

Acid using a Palladium Catalysed Aminocarbonylation Reaction’ Organic Process Research and

Development, 1999, 3, 60.

29). J. A. Blackie, N. J. Turner and A. S. Wells, ‘Concerning the Baker's Yeast (Saccharomyces

cerevisiae) Mediated Reduction of Nitroarenes and other N-O Containing Groups’ Tet.Letts.,1

997, 38, 3043.

28). ‘Sodium bis(2-methoxyethoxy)aluminium hydride in Petroleum Ether; A Reagent for the

Selective Reduction of Brominated Fatty Esters to Bromoalcohols’ Synthetic Commun., 1996, 26,

1143.

27). I. P. Andrews, N. J. Lewis, A. McKillop and A. S. Wells, ‘Oxidation of Substituted Pyridines

PyrCHRSiMe3 and Substituted Quinolines QnCH2RSiMe3 with Hypervalent Iodine Reagents’

Heterocycles,1996, 43, 1151.

26). I. P. Andrews, R. Bannister, S. K. Etridge, V. M. Mullane and A. S. Wells, ,Phosphorus

Mediated Cyclisation of a beta-Aminoacrylamide to a Quinoline:a Simple Synthesis of SK&F

96067’ Tet.Letts., 1995, 36, 7743.

25). I. P. Andrews, N. J. Lewis, A. McKillop and A. S. Wells, ‘Oxidation of Substituted Pyridines

PyrCH2X(X =H,COOR,COC6H5) with Hypervalent Iodine Reagents’ Heterocycles, 1994, 38,

713.

24). C. Davey, L. Powell, N. J. Turner and A. Wells, ‘Regioselective Reduction of Substituted

Dinitroarenes using Baker's Yeast’ Tet.Letts., 1994, 35, 7867.

23). ‘A Convenient Synthesis of Ttriaryl and Trialkyl Phosphine Dichlorides by Oxidation of

Tertiary Phosphines with Bis(trichloromethyl)carbonate('Triphosgene')’ Synthetic Commun.,

1994, 24, 1715.

22). C. L. Davey, L. W. Powell, .J. Turner and A. Wells, ‘Regioselective Reduction of Disubstituted

Dinitroarenes using Baker's Yeast’ Preparative Biotransformations, 2:8:9. Pub. Wiley 1995.

21). C. L. Davey, L. W. Powell, N. J. Turner and A. Wells, ‘Baker's Yeast Reductions of Aromatic

Nitro Compounds to Aromatic Amines’ Preparative Biotransformations, 2:8:1. Pub. Wiley 1995.

20). A. Houlton, R. M. G. Roberts, J. Silver and A. S. Wells, ‘Structures of Arene -

Cyclopentadienyl Iron(II) Salts:Benzene-Cyclopentadienylethyl Ketone Iron (II)

Hexafluorophosphate’, Acta Crystallogr.,Sec.C:Cryst.Struct.Commun. 1992, c48, 1081.

19). A. S. Wells, P. W. Sheldrake, I. Lantos and D. Eggleston, ‘Unexpected Synthesis of a 1H-

Pyrrolo{2,3-e]-1,2,4-Triazine’ J. Chem. Soc.Perkin Trans.1,1991, 1762.

18). I. Lantos, P. W. Sheldrake and A. S .Wells, ‘Novel Cage compounds from Inter-and

Intramolecular Diels-Alder Reactions of Heteroaromatic Azadienes and Methyl Coumalate with

Cyclo-1,5-octa-1,5-diene’ J.Chem.Soc.Perkin Trans. 1, 1990, 1887.

17). R. M. G. Roberts, J. Silver and A. S. Wells, ‘A Study of Acylmonophosphaferrocenes in

Strong Acids’ Inorg.Chim.Acta, 1989, 157, 45.

16). R. M. G. Roberts, J. Silver and A. S. Wells, ‘Mossbauer and NMR Spectroscopic Studies of

Diphosphaferrocenes in Trifluoromethanesulphonic Acid’ Inorg .Chim. Acta, 1986, 119, 1.

15). R. M. G. Roberts, J. Silver and A. S. Wells, ‘Structural studies of protonated

monophosphaferrocenes using Mossbauer and NMR spectroscopy’ Inorg. Chim. Acta, 1986,

118, 135.

14). R. M. G. Roberts, J. Silver and A. S. Wells, ‘Complexes of Diphosphaferrocenes with Lewis

acids and Copper(1) Silver(1) Salts’ Inorg. Chim. Acta, 1986, 119, 165.

13). R. M. G. Roberts and A. S. Wells, ‘Trifluoromethanesulphonic Acid as a Catalyst in the

Acylation of Phosphaferrocenes’ Inorg. Chim. Acta, 1986, 112, 167.

12). B. Lucas, R. M. G. Roberts and A. S. Wells, ‘Mossbauer Studies on Ferrocene Complexes IX,

Phosphaferrocences and their Protonated Derivatives’ J. Organomet. Chem, 1983, 256, 103.

11). R. M. G. Roberts and A. S. Wells, ‘A New Synthetic Route to Monophosphaferrocenes’ Inorg.

Chim.Acta, 1986, 112, 171.

10). R. M. G. Roberts, J. Silver and A. S. Wells, ‘An Iron-57 Mossbauer Study of

Phospaferricenuim Ions’ Inorg. Chim. Acta, 1987, 126, 561.

9). R. M. G. Roberts, J. Silver and A. S. Wells, ‘The Formation and Spectroscopic Identification of

some Alpha-Phosphaferrocenyl Carbenium Ions’ Inorg. Chim. Acta, 1989, 155, 197.

8). I. Lantos, P. W. Sheldrake and Andrew Wells, ‘Novel Cage Compounds from Inter-intra

Molecular Diels-Alder Reactions of 1,2,4-Triazines with Cycloocta-1,5-diene’ J .Chem. Soc.

Chem.Commun., 1988, 1482.

7). R. M .G. Roberts, J. Silver, A. S. Wells and S. P. Willkinson, ‘Synthesis and Structure of

Biphenyl-Cyclopentadienyl Iron(II) Hexafluorophosphates’, J.Organomet.Chem, 1987, 327, 247.

6). A. Houlton, G. K. Ofori-Okai, R. M. G. Roberts, J. Silver and A. S. Wells, ‘An Iron-57

Mossbauer Study of Arene-Cyclopentadienyl Iron(II) Salts’ J.Organomet.Chem., 1987, 326, 217.

5). R. M. G. Roberts and A. S. Wells, ‘Fridel-Crafts Acetylations of Alkyl-and

Phenylphosphaferrocenes’ Inorg. Chim. Acta, 1987, 130, 93.

4). R. M. G. Roberts and A. S. Wells, ‘Aluminium Chloride Induced Cleavage of

Diphosphaferrocenes in Aromatic Hydrocarbons; the Synthesis of

Arene/Phosphacyclopentadienyl Iron(II) Cations’ Inorg. Chim. Acta, 1987, 126, 67.

3). R. M. G. Roberts and A .S. Wells, ‘Acid-Catalysed Ketone Rearrangements of t-Butanoyl

Substituted Arene/Cyclopentadienyl Iron(II) Cations’ J.Organomet.Chem., 1986, 317, 233.

2). R. M. G. Roberts and A. S. Wells ’The Cleavage of Cyclopentadienyl -Substituted

Arene/Cyclopentadienyl Iron(II) Cations by Phospholyl Anions. A Facile Route to 1'-Substituted

Monophosphaferrocenes’ Inorg. Chim.Acta, 1986, 120, 53.

1).R. M. G. Roberts, J. Silver and A. S. Wells, ‘Mossbauer and NMR Studies of Protonated

Acyldiphosphaferrocenes’ Inorg. Chim. Acta, 1986, 119, 171.

Patents

14). Aesica Pharmaceuticals Ltd and CatScl Limited and Charnwood Technical Consulting Limited

‘Process’ UK application No. GB1500277.7.

13). D. Ainge, R. Sinclair, L. Vaz, A. Wells ‘Preparation of intermediates ((R )-2,2,4-trimethyl-

1,3-dioxolane-4-yl) methanol, 3-fluoro-4-nitro-phenol, and 1-(4-chloro-benzyl)piperidin-4-

ylamine’ WO 2009035407.

12). N. Barnwell, L-E Briggner, P.Cornwall, A. Wells Preparation of (5S)-5-[4-(5-chloro-pyridin-

2-yloxy)-piperidine-1-sulfonylmethyl]-5-methyl-imidazolidine-2,4-dione as a Metalloproteinase

Inhibitor and its Crystal Modification WO 2007106022.

11). S. Wildeman and Andrew Wells ‘New Process for Converting Aromatic Halo-Substituted

Dinitriles into Halo-Substituted Cyanocarboxylic Acids’ WO 2007035161 A1 2007.

10). J. Moseley, J. Gilday, D. Brown, A. Wells ‘Chemoenzymic Synthesis of 3-phenyl-2-

arylalkylthiopropionic acid Derivatives’ WO 2006064213 A2.

9). David Crowe, Neil Ward and Andrew Wells, ‘Process for the Preparation of Paroxetine’ WO

0129031.

8). David Crowe, Neil Ward and Andrew Wells, ‘A Novel Processes for the Manufacture of

Paroxetine’ WO 0129032.

7). ‘Novel Gemifloxacin Hydrochloride salt Formation’ GB Patent application 9820404.3,

6). J. Hayes, T. Walsgrove and A. Wells, ‘Preparation of a Naphthyridine Carboxylic acid

Methanesulfonate Sesquihydrate’ WO 200017199.

5). Separation of Gemifloxacin Enantiomers, GB Patent application 9820403.5

4). ‘Enzymic Resolution of Benzodiazepine Acetic Acid Esters’ WO 98/29561.

3). S. Etridge, J. Hayes, T. Walsgrove, A. Wells, ‘Process for the Aminocarbonylation of

Benzazepines and Benzodiazapines’ WO 97/24336.

2). A. Wells and N. Lewis ‘Preparation of Haloalkyl Methacrylate Monomers’ WO 91/ 09005.

1).A. Wells, N. Lewis, T. Walsgrove, P. Oxley, J. Fortunak ‘Process for the Preparation of

Substituted Indolone Derivatives (eg Ropinrole’)’ WO 94/15918.

Invited Presentations and Posters etc

71). ‘Medicinal vs. process chemistry routes’ Sustainable Chemistry in Industry, Durham

University, UK November 2015.

70). ‘Solvents - Optimising Choice and Minimising Impact’ Solvents Day University of York 30th

April 2015.

69). Current successes and future challenges for green chemistry in the pharmaceutical

industry’, Green Chemistry for Pharma, ACIB, Graz, Austria, Sept 2014.

68). Emma Lampard, Janet Scott, Darrell Patterson, Paul Murray, Andy Wells Intelligent Selection of

Greener Solvents Centre for Sustainable Chemical technologies Doctoral Training Centre Summer

Showcase, Bath, July 2014.

67). Dipolar Aprotic Solvents-Use In the Pharmaceutical Industry Centre for Sustainable

Chemical technologies Doctoral Training Centre Summer Showcase, Bath, July 2014.

66). A review of the progress in solvent selection –dipolar aprotics and other solvents of concern

Solvents Day, University of York, June 2014.

65). The biocatalysis toolbox - current successes and future victories SCI Process Chemistry

Conference 2-4 April 2014, Cambridge, UK.

64). Biocatalytic Synthesis of Chiral Amines – Which Way to Choose?’ CatSci conference 2014

‘Making Catalysis Work’, Cardiff, April 2014.

63). ‘Innovative Medicines Initiative: Sustainable chemical manufacturing methods for the 21st

century pharmaceutical industries’ Green Initiatives in Energy, Environment & Health, New Delhi

Dec 2-3 2013

62). ‘Expanding the Biocatalysis Tool Box - Both Breadth and Depth’ Ecochem Sunstainable

manufacturing expo, 18-21 November 2013, Basel.

61). ‘Trends in the adaption of green chemistry - chemical manufacturing methods

for 21st century pharmaceutical industries’ Trends in Organic Chemistry, Swedish Chemical

Society, Lund, April 2013.

60). Julia A. Griffen, Simon E. Lewis, Andrew Wells, Matthew D. Lloyd ‘Microbial Arene

Oxidation; Sustainable routes to biologically active molecules’ 2012 Gordon Green Chemistry

Research Conference, Italy.

59). ‘Fluorine – both sinner and saint atom in pharmaceuticals’ Bath University Organic

Chemistry Seminar, Nov 2011.

58). M. Pourashraf, P. Turcotte, F. Samson-Thibault, A. Wells, M. Laplante, L-D Cantin, C.

Walpole, M. Tomaszewski ‘Green chemistry at AstraZeneca R&D Montreal: Focus on solvent

selection’ 242nd ACS National Meeting & Exposition, 2011.

57). Julia A. Griffen,

Simon E. Lewis, Tom C. Arnot,

Andy Wells ‘Microbial Arene Oxidation; Uses

in Synthesis’ Centre for Sustainable Chemical Technologies Summer Showcase, Bath 2011.

56). ‘Drivers for increasing sustainability in the pharmaceutical industry’, Centre for Sustainable

Chemical Technologies Summer Showcase, Bath 2011.

55). Conchita Jiménez-González, Peter Poechlauer, Rinus Broxterman, Bing-Shiou Yang, David am

Ende, James Baird, Carl Bertsch , Bob Hanna, Phil Dell’Orco, Henk Noorman, Sandy Yee, Raf

Reintjens , Andrew Wells, Vivianne Massonneau, Julie Manley ‘Key Green Engineering Research

Areas’, 15TH

Green Chemistry and Engineering Conference Washington, June 2011.

54). Neil Adlington, Eva Jakobsson, William Mckintosh, Andy Wells, Cecilia Frostne ’The use of

second generation Ionic liquids and emerging dipolar aprotic solvents in organic synthesis’ 15TH

Green Chemistry and Engineering Conference Washington, June 2011.

53). ‘Positives and negatives of using biocatalysis in the pharmaceutical Industry – why are we

all not at it! Frontiers in Biocatalysis, TU Delft, June 2011.

52). ‘IB as a source of new drug leads and a low carbon manufacturing technology for

pharmaceuticals and fine chemicals’ Industrial Biotechnology – a New Dawn for The Chemical

Industry, CPI Wilton Centre, March 2011.

51). Julia A. Griffen, Tom C. Arnot, Andy Wells, Simon E. Lewis ‘Sustainable Routes to High

Value Chiral Synthetic Intermediates’, Catalysis and Sensing for Health, Bath February 2011.

50). ‘Design of Greener synthetic routes and reduction and elimination of hazardous

substances’ The 3rd International Workshop on Safety Technology for Pharmaceutical & Chemical

Processes (STPCP 2010), Xi’An China Oct 2010.

49). ‘Environmental assessment of synthetic routes and identification and classification of

hazardous substances’ The 3rd International Workshop on Safety Technology for Pharmaceutical &

Chemical Processes (STPCP 2010), Xi’An China Oct 2010.

48). ‘Biocatalysis: Present practice and future trends’ Biocatalysis: Challenges for

Pharmaceuticals & Fine Chemicals, SCI conference, London, Oct 2010.

47). M. Pourashaf and A. Wells ‘Green Chemistry at AstraZeneca’ ACFAS, Montreal, May 2010.

46). ‘Towards more Sustainable Synthesis of Pharmaceuticals and Fine Chemicals’ 105th

Korean Chemical Society Congress, Ihncion, Korea, April 2010.

45).‘Greener Technology – In Search of a more Sustainable Future’ Sungkyunkwan University,

Seoul, Korea, April 2010.

44). ‘The Wonders of Biocatalysis’ Future of Industrial Biotechnology, Centre for Process

Innovation, March 2010.

43). ‘Green Chemistry –Applications in Process Chemistry’ Tianjin University, China, Oct 2009.

42). ‘Some Applications of Biocatalysis in the synthesis of pharmaceuticals-present practice and

future trends’ Asymchem Process Chemistry Symposium, 2009, Tianjin, China, Oct 2009.

41). Peter J. Dunn, Richard K. Henderson, Ingrid Mergelsberg, Andrew S. Wells

‘Moving towards Greener Solvents for Pharmaceutical Manufacturing – An Industry

Perspective’ 13th

Green Chemistry and Engineering Conference, College Park, MD, 2009.

40). ‘Synthetic Methodology Requirements - Power of partners-Shaping the Future’ Chemical

Innovation –Knowledge Transfer Network annual meeting , June 2009.

39). ‘Strategies and Technologies for Greener Synthesis of Pharmaceuticals’ The State Research

Centre of Industrialisation for Crystallisation Technology, Tianjin University, China, May 2009.

38). ‘Green Chemistry, Philosophy principles and Tools’ Working Together to Improve

Environmental Performance – Chinese Society of Environmental Sciences/AstraZeneca, Beijing,

China, May 2009.

37). ‘Biocatalysis, a Sustainable Technology for the Synthesis of Pharmaceuticals’ 2009 Pfizer

Green chemistry Symposium, Pfizer GPS, Sandwich, Kent, UK, 2009.

36). ‘Towards Greener and more Sustainable Synthesis of Pharmaceuticals’ Manchester Literary

and Philosophical Society – The Search for a Sustainable Future –Jan 2009.

35). ‘Greening Solvent Use in the Pharmaceutical Industry’ Green Solvents –Progress in Science

and Application, DECHEMA, Friedrichshafen, Sept 2008.

34). ‘Some Applications of Biocatalysis in the Synthesis of Pharmaceutical Intermediates’, ACS

ProSpectives Organic Reactions and Synthesis meeting Oct 2008, Philadelphia, USA, 2008.

33). ‘Biocatalytic Routes to the PPAR agonist AZD 4169’ Green Processing Symposium, Yale

University May 2008.

32). ‘Solvents in the Manufacture of Pharmaceuticals’ John Jeyes Symposium, Nottingham

University, March 2008.

31). ‘Green Chemistry in the Pharmaceutical Industry’ 25th

SCI Process Chemistry Symposium,

Cambridge UK, December 2007.

30). ‘Prudent Practices for the Organic Chemist!’ Mike Williams Symposium, Pfizer, Sandwich

UK, July 2007.

29). ‘UK Centre of Excellence in Biocatalysis,Biotransformations and Biocatalytic Manufacture

–CoEBio3’

11th

Annual Green Chemistry and Engineering Conference, Washington DC, USA, June

2007.

28). ‘The Use of Lipases as Versatile Catalysts in the Preparation of Novel Oxazolidinone

Antibacterials’ 11th

Annual Green Chemistry and Engineering Conference, Washington DC, USA,

June 2007.

27). ‘The Development of Generic Reaction Conditions for Metal-Catalysed Reactions’ 11th

Annual Green Chemistry and Engineering Conference, Washington DC, USA, June 2007.

26). ‘Some Success Stories from AstraZeneca Green Chemistry Outreach Projects’International

Symposium on Green Chemical Processes, Montreal, Oct 2006.

25). ‘Desiger Enzymes from Genes’ Department of Trade and Industry meeting, York University,

September 2006.

24). ‘Biocatalysis, Current and Future use in Mainstream Manufacturing in the USA’,

Department of Trade and Industry Global Watch Report September 2006.

23). Andrew S. Wells, Neil Adlington, Tove Åqvist ‘Green Oxidations in Organic Synthesis:

Learning from Nature?’10th

Annual Green Chemistry and Engineering Conference, Washington,

USA, June 2006.

22). Andrew S. Wells, Paul Bainbridge, Neil Adlington ‘Pharmaceuticals in the Environment:

Development of an Active Pharmaceutical Ingredient (API) Waste Treatment Software Tool’

10th

Annual Green Chemistry and Engineering Conference, Washington, USA, June 2006.

21). ‘Biocatalysts, Current and Future use in Mainstream Manufacturing’ US-UK Biocatalysis

Conference, , British Consulate General, Boston, MA, May 26th

2006.

20). L. L. Woodcock, G. M. Greenway, P. Watts, A. Wells and S. Eyley ‘Application of

Microreactors for Biocatalysis’ Biocatalysis: Enzymes, Mechanisms and Bioprocesses Biochemical

Society Meeting in association with Pro-Bio Faraday Annual Conference – Manchester, November

2005.

19). Andy Wells, Tom Eve and Maira Teria ‘Green Oxidations using Laccase –Mediator Systems’

Biocatalysis: Enzymes, Mechanisms and Bioprocesses, Biochemical Society Meeting in association

with Pro-Bio Faraday Annual Conference – Manchester, November 2005.

18). A. Wells and Vyv Coombe ‘On the Freshwater Ecotoxicity of some Common Ionic Liquids’

2nd

International Conference on Green and Sustainable Chemistry, Washington D.C., June 2005.

17). Pete Clark, Martyn Poliakoff and Andy Wells ‘Chemoselective Debenzylation of

Phamaceutical Intermediates in Supercritical CO2’ CONNECT 2005, Royal Australian Chemistry

Institute, July 2005.

16). ‘The Application of Fluorine Chemistry in the Pharmaceutical Industry’ CRYSTAL

Faraday 1st ‘Fluorum’ meeting, Syngenta, Jelott’s Hill, UK, April 2005.

15). ‘The Value of Biocatalysis in the Manufacture of Fine Chemicals’ New Challenges in

Synthesis for Pharmaceutical Products- Singapore Feb 2005 ASTAR/RSC workshop.

14). T. S. Eve, N. J. Turner and Andrew Wells, ‘Towards a Deracemisation of Hydroxylamine

Derivatives’ Pro-Bio Annual Conference, Warwick, UK, November 2004.

13). ‘Some Industrial Applications of Hydrolytic Enzymes in Japan’ DTI -Global Watch

Specialised Bioprocessing and Manufacturing: The Japanese Perspective, London, September 2004.

12). Pete Clark, Martyn Poliakoff and Andy Wells ‘Transformation of Pharmaceutically Active

Materials in Supercritical CO2’ INCA 7th

Summer School on Green Chemistry, Venice, Sept 2004.

11). ‘The Impact of Industrial Biotechnology on the Sustainability of the Manufacturing Base’

Department of Trade and Industry Global Watch Report, September 2004.

10). ‘Use of Lipases as non-chiral catalysts in the synthesis of a Novel Antibacterial’ New

Perspectives in Medicinal Chemistry, Romark Laboratories Symposium , Liverpool, May 2004.

9). ‘Synthesis of Intermediates and Active Pharmaceuticals using Biocatalysis’ British Embassy,

Toyko, 24th April 2004.

8) D. A. Pears and Andy Wells ‘Polyurea Microencapsulated Catalysts’ 21ST

SCI Process

Chemistry Symposium, Cambridge, Dec 2003.

6). ‘Baker’s Yeast reduction of Aromatic Nitro Compounds’ Effecting Change-Biocatalysis for

the 21st Century –Manchester, 2002.

5). ‘The use of Biocatalysis in Manufacturing Processes – a Process Chemists View’ Pro-Bio

Faraday Workshop, Warwick, 2002.

4) S. Rafiq, N. Turner and A. Wells, ‘Microbial Reduction of Aromatic Nitro Groups using

Saccharomyces Cerevisiae’ Biotrans '99 , Italy.

3) M. L. Gradley, K. Lawrie, A. Wells and J. Sime, ‘Applications for Selective Nitrile

Bioconversions ’ INBIO Europe '99.

2). J. Blackie, N. J. Turner and A. Wells, ‘Baker's Yeast Reduction of Aromatic Nitro Compounds’

Biochemical Engineering, Minnesota, 1997.

1).J. S. McGuinn, N. J. Turner and A. S. Wells, ‘Microbial Reduction of Carbon-Carbon Double

Bonds’, Biotrans' 97,France.

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