alkaloids ppt
TRANSCRIPT
Alkaloids
Alkaloids
Distribution Properties Role in plants
Defense compounds Animal poisoning
Lupine Groundsel Larkspur Jimson weed (Scopolamine) Henban (Atropine)
Other roles in plants
Lupines
Texas bluebonnet
Effects of alkaloids on humans
High biological activity Produce varying degrees of physiological and
psychological responses - largely by interfering with neurotransmitters others interfere with membrane transport, protein synthesis
or other processes In large doses - highly toxic - fatal In small doses, many have therapeutic value
muscle relaxants, tranquilizers, pain killers, mind altering drugs, chemotherapy
Psychoactive alkaloids
Although only a small percent are psychoactive, these get much focus
Affect the central nervous system - often by influencing neurotransmitters
Categories of psychoactive cmpds Stimulants Hallucinogens Depressants
May also be narcotic (addictive)
Psychoactive alkaloids
Stimulants Hallucinogens DepressantsCocaine Tropane alkaloids Morphine
Ephedrine Mescaline Codeine
Caffeine Psilocybin Heroin
Ergot alkaloids (LSD)
Alkaloid synthesis
Most alkaloids are synthesized from a few common amino acids (tyrosine, tryptophan, ornithine or argenine, aspartic acid, & lysine)
Nicotinic acid precursor for part of nicotine Purine precursor for caffeine Some alkaloids synthesized from terpenes - along
mevalonic acid pathway Generally classified by the predominant ring
structure and/or carbon skeleton
Tropane alkaloids
Many of these psychoactive alkaloids
Pyrrolizidine alkaloids
Piperidine alkaloids
Piperidine/Pyridine alkaloids
Purine alkaloids
Figure 3-5 Caffeine
Quinoline alkaloids
Isoquinoline alkaloids
Indole alkaloids
Vindoline
Vinblastine (Catharanthus)
Quinolizidine alkaloids
Steroidal alkaloids
Steroidal alkaloids
Diterpenoid alkaloids
Amine alkaloids
Alkaloids without heterocyclic nitrogen atoms
Other classes of alkaloids
Betalain alkaloids - pigment alkaloids Lycopodium alkaloids - restricted to club
mosses Peptide alkaloids