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  • Agilent Technologies GPSD Analyzer Solutions

    Agilent Science and Technology Symposium

    May 2014

    May 2014

    1

  • What is an Analyzer

    An Analyzer is a factory-configured GC or GC/MSD system configured, tuned and tested for the application prior to

    delivery to the customer’s laboratory. Capillary

    Flow Technology

    Retention Time

    Locking

    RTL Database

    Deconvolution Reporting Software MRM

    Database

    App. Specific Supplies

    Synchronous SIM/SCAN

    Sample Prep WorkBench

    Capillary Flow

    Technology

    Retention Time

    Locking

    Specialized Columns

    and Accessories

    Multichannel Customized

    Configurations

    Valves

    Sample Prep WorkBench

    May 2014

    Agilent Science and Technology Symposium 2014 2

  • Intrinsic Value for Analyzer Solutions

    Configured with Market Leading Hardware, and Leveraging Technology

    Innovation

    Databases and Libraries developed and maintained

    by Agilent Technologies

    Methods Developed by Agilent’s Top Application

    Experts and Collaborators

     Receive systems optimized for a particular analysis

     Obtain accurate and reliable results

     Save time and reduce cost for system configuration and method development

     Chromatography guarantee  Quicker start to system calibration

    and validation

    …Faster Application Startup with a Guaranteed Method

    Sample Ready

    Order Fulfillment

    Standard Installation &

    Familiarization Customer Method Development

    and Verification

    Agilent Method

    Development Application checkout

    Analyzer Installation &

    Familiarization

    Customer Method

    Verification Order

    Fulfillment Agilent Analyzers

    End User Configured

    Order Placement

    Sample Ready

    Time Savings

    May 2014

    Agilent Science and Technology Symposium 2014 3

  • App. optimized consumables

    GPD Analyzers The Solution Approach

    Individual Components

    produced

    Individual Components Tested (OFN)

    System assembled

    App. method developed on cust. system

    System checkout on App. mix

    Run 1st customer sample

    customization or optimization

    method

    On-going maintains/service

    Factory FSE

    Factory

    Analyzer Delivery Point

    FSS

    Report follows Standard Method

    System with application setup

    w/o Analyzer

    FSS (specialist) I&F

    Std. HW, SW

    Data CD

    Box Delivery Point

    Configured for a specific analysis with factory setup, chemical test, I&F, and field verified

    performance

    May 2014

    Agilent Science and Technology Symposium 2014 4

  • Intrinsic Value for Analyzer Solutions

    Configured with Market Leading Hardware, and Leveraging Technology

    Innovation

    Databases and Libraries developed and maintained

    by Agilent Technologies

    Methods Developed by Agilent’s Top Application

    Experts and Collaborators

     Receive systems optimized for your particular analysis

     Obtain accurate and reliable results

     Save time and reduce cost for system configuration and method development

     Chromatography Guarantee  Quicker start to system calibration

    and validation

    May 2014

    Agilent Science and Technology Symposium 2014 5

  • Typical Analyst Requirements Agilent Analyzer Solutions

    Sample Prep

    Sample Introduction Separation Detection

    Validated Reports

    Agilent’s Analyzers Provide

    Customer’s Responsibility

    Customer’s Responsibility

    May 2014

    Agilent Science and Technology Symposium 2014 6

  • Selected Agilent GPSD Analyzers Application based Solutions

    Food Safety • Pesticides - Sensitivity (TQ) • Pesticides – Sens., Op. Ease (TQ) • Pesticides – Economical (SQ) • Enhanced PAHs – Sensitivity (TQ)* • Enhanced PAHs – Economic. (SQ)*

    Environmental • Pesticides - Sensitivity (TQ) • Pesticides – Sens., Op. Ease (TQ) • Pesticides – Economical (SQ) • Enhanced PAHs – Sensitivity (TQ)* • Enhanced PAHs – Economic. (SQ)* • Semi-Volatiles – Economical (SQ) • Greenhouse Gases (GC)

    * - New for 2014 * - New for 2014

    May 2014

    Agilent Science and Technology Symposium 2014 7

  • Selected Agilent GPSD Analyzers Application based Solutions

    Energy and Chemical • LVO High Capacity RGA* • LVO Fast RGA* • LVO Fuels (D4815, D5580, D3606)* • Fast RGA with He or H2 Carrier • Extended Natural Gas Analyzer • Natural Gas Analyzer • Transformer Oil Gas Analyzer

    (TOGA)

    Forensics and Toxicology • Controlled Substances – He (SQ)* • Controlled Substances – H2 (SQ) * • Blood Alcohol (GC) • Blood Alcohol – MS Confirmation (SQ)* • Toxicology Screening (SQ)

    * - New for 2014 * - New for 2014

    May 2014

    Agilent Science and Technology Symposium 2014 8

  • Selected Agilent GPSD Analyzers Application based Solutions

    Pharmaceutical (USP 467) • Residual Solvents (GC) • Residual Solvents (MS)

    February 19, 2014

    9 May 2014

    Agilent Science and Technology Symposium 2014 9

  • Agilent Technologies GPSD Analyzer Solutions

    Select GC/MSD Analyzers

    May 2014

    May 2014

    10

  • P&EP 3.0 GC/MS/MS Pesticides Analyzer

    Get Customers on the Analytical FAST TRACK

    May 2014

    11

  • Feature Elements for P&EP 3.0 Analyzer GC/MS/MS Pesticides and Environmental Pollutants Analyzer • MRM database with ~1100 compounds and

    ~8500 optimized transitions including 710+ pesticides and breakdown products

    • GUI that facilitates building MRM acquisition and quantitation methods based on customer’s compound list

    • Retention Time Locked separation for reliable peak identification and quantitation for CF and CP BF methods

    • Multimode inlet for large volume injection helps optimize detection limit performance

    • Opt 114 UI S/SL for when there is no requirement for optimal LOD performance

    • Capillary Flow Technology Backflush for faster cycle time and reduced system maintenance Pesticide & Environmental Pollutant Analyzer 3.0

    May 2014

    Agilent Science and Technology Symposium 2014 12

  • Note: In this example, the acquisition is in full-scan mode.

    Acquire RTLock Calibration Data…

    Now available for both CP & CF methods!

    May 2014

    Agilent Science and Technology Symposium 2014 13

  • Home Screen of the MRM Database Sure it’s an Excel file, but…

    No More vLookup!

    New GUI thanks to the efforts of Pascal Vattaire and Laurent Pascaud!

    May 2014

    Agilent Science and Technology Symposium 2014 14

  • View of “Target Compound List”

    May 2014

    Agilent Science and Technology Symposium 2014 15

  • Build MRM Table Step 1 – Select Method of Choice Step 2 – Select Quant & Qualifier ions

    May 2014

    Agilent Science and Technology Symposium 2014 16

  • Two Methods Can be developed: 1) MRM Acquisition Method (qqqacqmethod.xml) via the Compound List Assistant (CLA ) 2) Quant Method (quantmethod.xml) via the MRM database

    May 2014

    Agilent Science and Technology Symposium 2014 17

  • C.-K. Meng, Agilent Application Brief 5989-6018EN

    • Elimination of long “baked out” at a high temperature to remove less volatile, late eluting matrix components

    • Reduced analysis time • Increased column life time • Prevention of the MS source contamination • Less frequent MS source maintenance

    Increased sample

    throughput

    Column Backflush - Benefits

    May 2014

    Agilent Science and Technology Symposium 2014 18

  • Column Backflush - Benefits

    M. Mezcua, M.A. Martinez-Uroz, P.L. Wylie, A.R. Fernandez-Alba, J. AOAC Int. 92 (2009) 1790-1806.

    Improved Ruggedness

    Reduced Maintenance

    May 2014

    Agilent Science and Technology Symposium 2014 19

  • Overlays of GC-MS/MS chromatograms for selected analytes (at 50 ng/g ) obtained within a 2.5-day sequence of 125 dietary supplement sample injections

    Deltamethrin m/z 253>174

    Ginseng Root Powder

    Saw Palmetto Berry Powder

    Scutellaria Powdered Extract

    2x10

    0

    0.5

    1

    1.5

    2

    2.5

    3

    3.5

    4

    4.5

    Counts vs. Acquisition Time (min) 18.1 18.2 18.3 18.4 18.5 18.6

    3x10

    0

    0.5

    1

    1.5

    2

    2.5

    3

    3.5

    Counts vs. Acquisition Time (min) 4 4.05 4.1 4.15 4.2

    3x10

    0

    0.5

    1

    1.5

    2

    2.5

    3

    3.5

    4

    Counts vs. Acquisition Time (min) 4 4.05 4.1 4.15 4.2

    Dichlorvos m/z 185>93

    3x10

    0

    1

    2

    3

    4

    5

    Counts vs. Acquisition Time (m

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