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Agilent Technologies GPSD Analyzer Solutions

Agilent Science and Technology Symposium

May 2014

May 2014

1

What is an Analyzer

An Analyzer is a factory-configured GC or GC/MSD system configured, tuned and tested for the application prior to

delivery to the customer’s laboratory. Capillary

Flow Technology

Retention Time

Locking

RTL Database

Deconvolution Reporting Software MRM

Database

App. Specific Supplies

Synchronous SIM/SCAN

Sample Prep WorkBench

Capillary Flow

Technology

Retention Time

Locking

Specialized Columns

and Accessories

Multichannel Customized

Configurations

Valves

Sample Prep WorkBench

May 2014

Agilent Science and Technology Symposium 2014 2

Intrinsic Value for Analyzer Solutions

Configured with Market Leading Hardware, and Leveraging Technology

Innovation

Databases and Libraries developed and maintained

by Agilent Technologies

Methods Developed by Agilent’s Top Application

Experts and Collaborators

 Receive systems optimized for a particular analysis

 Obtain accurate and reliable results

 Save time and reduce cost for system configuration and method development

 Chromatography guarantee  Quicker start to system calibration

and validation

…Faster Application Startup with a Guaranteed Method

Sample Ready

Order Fulfillment

Standard Installation &

Familiarization Customer Method Development

and Verification

Agilent Method

Development Application checkout

Analyzer Installation &

Familiarization

Customer Method

Verification Order

Fulfillment Agilent Analyzers

End User Configured

Order Placement

Sample Ready

Time Savings

May 2014

Agilent Science and Technology Symposium 2014 3

App. optimized consumables

GPD Analyzers The Solution Approach

Individual Components

produced

Individual Components Tested (OFN)

System assembled

App. method developed on cust. system

System checkout on App. mix

Run 1st customer sample

customization or optimization

method

On-going maintains/service

Factory FSE

Factory

Analyzer Delivery Point

FSS

Report follows Standard Method

System with application setup

w/o Analyzer

FSS (specialist) I&F

Std. HW, SW

Data CD

Box Delivery Point

Configured for a specific analysis with factory setup, chemical test, I&F, and field verified

performance

May 2014

Agilent Science and Technology Symposium 2014 4

Intrinsic Value for Analyzer Solutions

Configured with Market Leading Hardware, and Leveraging Technology

Innovation

Databases and Libraries developed and maintained

by Agilent Technologies

Methods Developed by Agilent’s Top Application

Experts and Collaborators

 Receive systems optimized for your particular analysis

 Obtain accurate and reliable results

 Save time and reduce cost for system configuration and method development

 Chromatography Guarantee  Quicker start to system calibration

and validation

May 2014

Agilent Science and Technology Symposium 2014 5

Typical Analyst Requirements Agilent Analyzer Solutions

Sample Prep

Sample Introduction Separation Detection

Validated Reports

Agilent’s Analyzers Provide

Customer’s Responsibility

Customer’s Responsibility

May 2014

Agilent Science and Technology Symposium 2014 6

Selected Agilent GPSD Analyzers Application based Solutions

Food Safety • Pesticides - Sensitivity (TQ) • Pesticides – Sens., Op. Ease (TQ) • Pesticides – Economical (SQ) • Enhanced PAHs – Sensitivity (TQ)* • Enhanced PAHs – Economic. (SQ)*

Environmental • Pesticides - Sensitivity (TQ) • Pesticides – Sens., Op. Ease (TQ) • Pesticides – Economical (SQ) • Enhanced PAHs – Sensitivity (TQ)* • Enhanced PAHs – Economic. (SQ)* • Semi-Volatiles – Economical (SQ) • Greenhouse Gases (GC)

* - New for 2014 * - New for 2014

May 2014

Agilent Science and Technology Symposium 2014 7

Selected Agilent GPSD Analyzers Application based Solutions

Energy and Chemical • LVO High Capacity RGA* • LVO Fast RGA* • LVO Fuels (D4815, D5580, D3606)* • Fast RGA with He or H2 Carrier • Extended Natural Gas Analyzer • Natural Gas Analyzer • Transformer Oil Gas Analyzer

(TOGA)

Forensics and Toxicology • Controlled Substances – He (SQ)* • Controlled Substances – H2 (SQ) * • Blood Alcohol (GC) • Blood Alcohol – MS Confirmation (SQ)* • Toxicology Screening (SQ)

* - New for 2014 * - New for 2014

May 2014

Agilent Science and Technology Symposium 2014 8

Selected Agilent GPSD Analyzers Application based Solutions

Pharmaceutical (USP 467) • Residual Solvents (GC) • Residual Solvents (MS)

February 19, 2014

9 May 2014

Agilent Science and Technology Symposium 2014 9

Agilent Technologies GPSD Analyzer Solutions

Select GC/MSD Analyzers

May 2014

May 2014

10

P&EP 3.0 GC/MS/MS Pesticides Analyzer

Get Customers on the Analytical FAST TRACK

May 2014

11

Feature Elements for P&EP 3.0 Analyzer GC/MS/MS Pesticides and Environmental Pollutants Analyzer • MRM database with ~1100 compounds and

~8500 optimized transitions including 710+ pesticides and breakdown products

• GUI that facilitates building MRM acquisition and quantitation methods based on customer’s compound list

• Retention Time Locked separation for reliable peak identification and quantitation for CF and CP BF methods

• Multimode inlet for large volume injection helps optimize detection limit performance

• Opt 114 UI S/SL for when there is no requirement for optimal LOD performance

• Capillary Flow Technology Backflush for faster cycle time and reduced system maintenance Pesticide & Environmental Pollutant Analyzer 3.0

May 2014

Agilent Science and Technology Symposium 2014 12

Note: In this example, the acquisition is in full-scan mode.

Acquire RTLock Calibration Data…

Now available for both CP & CF methods!

May 2014

Agilent Science and Technology Symposium 2014 13

Home Screen of the MRM Database Sure it’s an Excel file, but…

No More vLookup!

New GUI thanks to the efforts of Pascal Vattaire and Laurent Pascaud!

May 2014

Agilent Science and Technology Symposium 2014 14

View of “Target Compound List”

May 2014

Agilent Science and Technology Symposium 2014 15

Build MRM Table Step 1 – Select Method of Choice Step 2 – Select Quant & Qualifier ions

May 2014

Agilent Science and Technology Symposium 2014 16

Two Methods Can be developed: 1) MRM Acquisition Method (qqqacqmethod.xml) via the Compound List Assistant (CLA ) 2) Quant Method (quantmethod.xml) via the MRM database

May 2014

Agilent Science and Technology Symposium 2014 17

C.-K. Meng, Agilent Application Brief 5989-6018EN

• Elimination of long “baked out” at a high temperature to remove less volatile, late eluting matrix components

• Reduced analysis time • Increased column life time • Prevention of the MS source contamination • Less frequent MS source maintenance

Increased sample

throughput

Column Backflush - Benefits

May 2014

Agilent Science and Technology Symposium 2014 18

Column Backflush - Benefits

M. Mezcua, M.A. Martinez-Uroz, P.L. Wylie, A.R. Fernandez-Alba, J. AOAC Int. 92 (2009) 1790-1806.

Improved Ruggedness

Reduced Maintenance

May 2014

Agilent Science and Technology Symposium 2014 19

Overlays of GC-MS/MS chromatograms for selected analytes (at 50 ng/g ) obtained within a 2.5-day sequence of 125 dietary supplement sample injections

Deltamethrin m/z 253>174

Ginseng Root Powder

Saw Palmetto Berry Powder

Scutellaria Powdered Extract

2x10

0

0.5

1

1.5

2

2.5

3

3.5

4

4.5

Counts vs. Acquisition Time (min) 18.1 18.2 18.3 18.4 18.5 18.6

3x10

0

0.5

1

1.5

2

2.5

3

3.5

Counts vs. Acquisition Time (min) 4 4.05 4.1 4.15 4.2

3x10

0

0.5

1

1.5

2

2.5

3

3.5

4

Counts vs. Acquisition Time (min) 4 4.05 4.1 4.15 4.2

Dichlorvos m/z 185>93

3x10

0

1

2

3

4

5

Counts vs. Acquisition Time (m