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New Agilent 5977 Series GC/MSD
January 15, 2013 2
The 5977 is the new Agilent GC/MSD platform and replaces the
5975C and 5975E systems
• Improves performance with high sensitivity Extractor Ion
Source
• MassHunter GC/MS Acquisition
• MassHunter and MSD ChemStation data analysis
• Integration of new Agilent Vacuum Pumps brings intelligent
operation
• Direct Communication between 7890B and 5977A for more
productivity
New Agilent 5977 Series GC/MSD
What is the same as 5975?
January 15, 2013 3
Quality
Reliability
Proven core technology since 5973/5975
• Inert Ion Source
• Heatable Gold Quartz Quadrupole
• Triple Axis Detector
• High Energy Diode
• Triple Channel EM Detector
• Productivity Software
(MSD ChemStation Data Analysis)
New Agilent 5977 Series GC/MSD
January 15, 2013 4
What is new with 5977?
Better Performance
• High Sensitive Extractor Ion Source
• Improved Agilent Vacuum Pump
More Productivity
• Direct Communication 7890B5977A
• Protect system
• Vent the system faster
• Power save (Sleep/Wake)
• MassHunter Software
• Data Acquisition (Method/Sequence)
• Data Analysis
New Extractor Ion Source for 5977
Page 5
Why the Extractor EI Source?
Increase in ion count
True increase in sensitivity
Better trace level precision
Lower IDL and MDL
Proven sensitivity increase demonstrated with
over 1500 7000 Series GC/TQ!
January 15, 2013
Comparison between Inert Ion Source and
Extractor Ion Source
Page 6
Repeller
(Push)
Drawout Plate
Ion Focus Lens
Entrance Lens
Ionization area
Ions
Inert Ion Source
Extractor Lens
(Pull)
Extractor Source
More ions to
Mass Filter
Mass Filter
January 15, 2013
How Extractor Ion source with “Etune” be seen in
the Chromatogram?
January 15, 2013 7
Blue – Extractor 40ppb solution (SVOC)
Red – Standard 40ppb solution (SVOC)
More improvements on 5977’s Extractor Ion Source:
Improved Thermal Profile
Page 8
Why is this important? Better performance of high boilers
i.e. PAH even at lower concentration!
10 Injections 80 min analysis
Good repeatability of
PAH even at the trace
level (5ppb)!!
Improvement for better Mass
Spectrometer of Gas Chromatograph
January 15, 2013
Sensitivity Specifications of the 5977
January 15, 2013 9
Full Scan EI Specification: S/N - Signal-to-Noise
The 5977 in scan mode has some background noise even if only OFN standard is injected, therefore the traditional Signal-to-Noise (S/N) is used as specification.
Agilent’s 5977 has the highest S/N (1500:1) with Extractor Ion Source among the SQ system. (1pg OFN)
SIM Specification: IDL - Instrument Detection Limit
Agilent 5977A uses this sensitivity specification for detection
techniques where no or little noise is generated, such as when OFN standard is injected. IDL is a new specification for SIM, but have been used with MS/MS for over a year.
5977A GC/MSD IDL Specification
IDL is a statistically derived value from the precision (%RSD) of 8
consecutive, splitless injections of 100fg OFN at 99 % confidence
level. The more precise instruments (lower %RSD) will generate lower
IDLs.
The Agilent 7890B/5977A with an ALS or CTC autosampler has the
following specifications:
January 15, 2013 10
Ion Source type High Vacuum pump type IDL of OFN by 8 replicates of ALS*
Extractor Source Turbo Pump 10fg
Inert Source
Turbo Pump 24fg
Diffusion Pump 30fg
*Systems without an Autosampler will have only S/N specification.
These are installation specification, performed on customer site, immediately
after installation and carry a lot more value than a reference specs.
Why IDL specification is useful for the 5977 in SIM?
Influence of Noise in S/N specs
• In SIM (or MS/MS) when the Noise is too low, such as during acquisition of an OFN standard, S/N results may not give the best characterization
• If the noise level is insignificant - varies a lot and too low- the derived value from it (S/N) also becomes insignificant
Value of IDL
• IDL is derived from reproducibility/precision results, the same metrics most users utilize every day in their work. The IDL statistical process is the same used for Method Detection Limit calculations, and the %RSD values are tools to monitor analytical performance
• IDL characterizes the whole system – AS, GC, MS- giving confidence in overall reliability. It is the results of 8 consecutive injections, unlike S/N in a single shut, which can be influenced by many parameters/conditions
January 15, 2013 11
The Influence of the low Noise on S/N values Same Data File, RMS, 5 Second Noise Region
Noise region: 5.66min - 5.74 min
S/N: 3335
Noise region: 5.65min - 5.73 min
S/N: 10785
A 0.01 min. shift in the noise region resulted a 6000 higher S/N value.
When the noise is insignificant (low), the derived S/N value is also insignificant!
Noise region:
5.65min-5.73 min
Noise region:
5.66min-5.74 min
S/N S/N
January 15, 2013 12
Better HW Features: Agilent Turbo Pump (V304)
Page 13
Agilent Quality Standard
TwisTorr 304 FS
Innovation for:
•Higher pumping performance
• especially for He and H2
•High reliability
• lower cost of operation
January 15, 2013
Press release : http://www.agilent.com/about/newsroom/presrel/2012/19dec-ca12077.html
Better HW Features: Agilent Rough Pumps
Page 14
New DS42i New IDP-3c
High performance
Energy saving design “Inverter” mode not active with diff pump
High performance
Oil-free scroll pump
NH3 CI compatible
with Agilent Quality Standards
January 15, 2013
Better HW Features: Power consumption saving of
MSD by Inverter Pump (DS42i)
15
0
100
200
300
400
Operation mode Sleep Mode
320W
190W
What this means to the
laboratory cost of ownership?
January 15, 2013
Example of Cost simulation of saving power with
Agilent 7890B/5977A at Environmental Lab
Assumptions
• GC/MSD cycle time: 40 minutes (30min for data acq./10 min for cool down & prep)
• Sample: 30 samples/day
• Working day: 5 days/week, no operating on Sat/Sun
GC/MSD wake time = 40 min/sample * 30 samples * 5 days/week
= 6,000 min/week = 100 hours/week
= 32 kWh
GC/MSD sleep time = 168 hours/week – 100 hours/week = 68 hours/week
= 13 kWh
Total Power usage (1 week) = 45 kWh (with Sleep mode)
Total Power Usage (1 week) = 54 kWh (without Sleep mode
Weekly MS Power saving per instrument = 9kWh (17%)
January 15, 2013 16
3 ways to go to Sleep mode
January 15, 2013 17
From the Sequence Keyword
From the menu item of
MassHunter
From the 7890B Keypad
Key features of “Direct Communication” between
7890B and 5977A
Page 18
Sleep/Wake mode
• In sleep mode, MSD will go to the Power save mode (320W 190W)
Laboratory Operating Cost Reduction (see the previous slide for detail)
Safety Control
• If 5977A MSD Pumps fail, 7890B will shut off the gas supply for protecting
GC/MSD system.
Cool Down MSD Faster (FastVent)
• When MSD Vent Cycle started, GC will cool down MSD analyzer at the
optimum gas flow to MSD.
Helium Carrier gas : This prevents wasting gas.
Hydrogen Carrier gas: This reduces the risk of explosion in MSD.
Less time to wait for cooling down MSD analyzer (40 min 25 min when cooling
down from 280C to 100C)
January 15, 2013
MassHunter GC/MS Acquisition for GC/MSD
Unified GC/MS Acquisition and
MassHunter Data Analysis; with
MSD ChemStation workflow for GC/MSD
January 15, 2013 19
GC/MSD Software
January 15, 2013 20
MassHunter Qual
MassHunter Quant MH
CS
MassHunter GC/MS Acquisition
And Use Either
MassHunter Data Analysis
OR
MSD ChemStation Data Analysis MSD ChemStation DA
G1701FA
The Value of G1701FA Software
All Inclusive G1701FA Software Package
• MassHunter GC/MS Acquisition
• MassHunter Quantitative Analysis
• MassHunter Qualitative Analysis
• MSD ChemStation Data Analysis
• 21CFR11 Compliance tools (Acquisition and
MH Quantitative Analysis)
• GC/MS and LC/MS Translators
Collated User Information
• Workflow guides, Video Tutorials, all in one
location
Support
• 1yr Upgrade, Updates, and Phone Support
• Training and Familiarization options
MSD ChemStation DA
MassHunter Qual
MassHunter Quant
January 15, 2013 21
MassHunter GC/MSD Rollout Plan
Feb 2013: • Add GC/MSD systems
– 5975 & 5977 Series GC/MSD
– 7890B & 7820A
– 7697A HSS
• Continue MassHunter GC/MS and GC
support
– 7000 Series Triple Quad GC/MS
– 7200 Series Q-TOF GC/MS
• MH DrugQuant
• GC and GC/MSD Data Analysis with
MassHunter OR MSD ChemStation
modes
Late 2013: • Expand Compatibility
– 5973 Network
– 6890 Network & 6850 GC
• MH EnviroQuant
January 15, 2013 22
23
ASK When can I start using
MassHunter if I buy a 5977
Series GC/MSD?
ANSWER Anytime!
Without added cost!
January 15, 2013
GC/MSD Acquisition Methods
MSD Productivity ChemStation MassHunter GC/MS Acquisition
January 15, 2013 24
GC/MS Acquisition Methods are Transparent
from MSD ChemStation to MassHunter GC/MS (Except PAL)
Migrate MSD ChemStation Data to MassHunter
January 15, 2013 25
Data
Data
Data
MassHunter Quant
MassHunter Qual
MSD ChemStation (.D)
WorkStation (.SMS)
Generic (.CDF)
Migrate MSD ChemStation Quantitative Methods to
MassHunter
January 15, 2013 26
MSD ChemStation (QDB.MTH)
WorkStation (.mth)
MassHunter Quant
Method
Method
Expanded Capabilities: 7890B/5977A Improving the Industry Standards for GC/SQ
Higher Ion Count • Extractor EI source
• Increased ion count
• S/N > 1500:1
• IDL < 10 fg (industry first)
• Improved thermal profile
Save Time & Energy •Sequence Scheduler
• “Standby” post run
• “Ready to run” from standby
• “Bake Mode” as needed
• Factory backflush option
• Fast Vent capability
• DS42i rough pump“standby”
power reduction
Safety/Protection • Vacuum failure Shut off gas (He or H2)
Better Vacuum by
Agilent Pump • New Agilent V304 Turbo
• TwisTorr • Molecular Drag technology
• Improved pumping light gases
• H2 (220 L/s); He (255 L/s)
• Agilent Floating Suspension
• Longer life
• Quiet operation
Faster Scanning • 20,000 u/s
• But best choice of fast
scanning GC/MS is GC/QTOF
7890B GC Features • EMF, calculator, etc.
All of 5975’s features also built in 5977, such as “Hot Gold Quad”, SIM/Scan,
Gain tuning, Triple-Axis Detector, Trace Ion Detection, Auto CI, etc..
January 15, 2013 27