advances and controversies in clinical...
TRANSCRIPT
Parc 55 Wyndham55 Cyril Magnin Street San Francisco, CA
Advances and Controversies in Clinical NutritionSan Francisco, California February 25-27, 2011
D I E T A R Y S U P P L E M E N T S • O B E S I T Y, D I E T & D I S E A S E • N U T R I T I O N , D I E T & A G I N G
E X H I B I T O R S , P P. 2 8 – 2 9
O N - S I T E P R O G R A M &E X H I B I T G U I D E
Wyndham Parc 5555 Cyril Magnin Street San Francisco, CA
A Publication of the American Society for Nutrition • www.nutrition.org
Iron loading and ferroportin regulation in macrophages
Osteoclastogenesis and obesity in mice
Total fiber intake and reduced weight gain in women
Commentary: Domestic animals in agricultural and biomedical research–an endangered enterprise
Symposium: Food Addiction–Fact or Fiction?
THE JOURNAL OF NUTRITIONJNMarch 2009 • Volume 139 • Number 3
TH
E JO
UR
NA
L O
F N
UT
RIT
ION
MA
RC
H 2009
VO
LU
ME
139 NO
. 3P
ages 427–634
•
3
nutritioncover_March09.q
xd 2/10/09 11:08 PM P
age 1
American Society for NutritionExcellence in Nutrition Research and Practicewww.nutrition.org
The American Society for Nutrition (ASN) is the authoritative voice on nutrition, and publisher of The American Journal of Clinical Nutrition (AJCN) and The Journal of Nutrition (JN). Established in 1928 and a constitu-ent organization of the Federation of American Societies for Experimental Biology (FASEB), ASN’s nearly 4,000 mem-bers work in academia, practice, government and industry. Members benefit from savings on professional develop-ment and continuing education credit, as well as critical public information efforts that inform Congress, federal agencies, media and consumers. ASN advances excellence in research and practice through its publications, education, public affairs and membership programs.
• Advances in Nutrition
Connect with
ASN ONLINE www.nutrition.org/twitter
Delicious
Slash Dot
Newsvine
Yahoo
Microsoft
App Store
Qik
Tumblr
Behance
Friendster
RSS
Flickr
MySpace
Mixx
FriendFeed
SlideShare
Yahoo Buzz
MSN
Amazon
Vimeo
WordPerss
Design Float
Bebo
StumbleUpon
Skype
YouTube
Netvibes
Apple
Last.fm
Viddler
Blogger
Deviant Art
Squidoo
Retweet
Digg
Technorati
Google Talk
AOL
MobileMe
Mister Wong
Virb
Posterous
Design Bump
Share This
Update #1
Google Buzz
Ebay
Gowalla
Podcast
Button Red
Picasa
Feedburner
ICQ
Paypal
Button Blue
Button White
Bing
WordPress (blue)
Metacafe
Heart
Button Orange
Button Light Blue Button Yellow
Meetup
Drupal
Yelp
Star
Green
www.nutrition.org/facebook
www.nutrition.org/linkedin
Delicious
Slash Dot
Newsvine
Yahoo
Microsoft
App Store
Qik
Tumblr
Behance
Friendster
RSS
Flickr
MySpace
Mixx
FriendFeed
SlideShare
Yahoo Buzz
MSN
Amazon
Vimeo
WordPerss
Design Float
Bebo
StumbleUpon
Skype
YouTube
Netvibes
Apple
Last.fm
Viddler
Blogger
Deviant Art
Squidoo
Retweet
Digg
Technorati
Google Talk
AOL
MobileMe
Mister Wong
Virb
Posterous
Design Bump
Share This
Update #1
Google Buzz
Ebay
Gowalla
Podcast
Button Red
Picasa
Feedburner
ICQ
Paypal
Button Blue
Button White
Bing
WordPress (blue)
Metacafe
Heart
Button Orange
Button Light Blue Button Yellow
Meetup
Drupal
Yelp
Star
Green
Delicious
Slash Dot
Newsvine
Yahoo
Microsoft
App Store
Qik
Tumblr
Behance
Friendster
RSS
Flickr
MySpace
Mixx
FriendFeed
SlideShare
Yahoo Buzz
MSN
Amazon
Vimeo
WordPerss
Design Float
Bebo
StumbleUpon
Skype
YouTube
Netvibes
Apple
Last.fm
Viddler
Blogger
Deviant Art
Squidoo
Retweet
Digg
Technorati
Google Talk
AOL
MobileMe
Mister Wong
Virb
Posterous
Design Bump
Share This
Update #1
Google Buzz
Ebay
Gowalla
Podcast
Button Red
Picasa
Feedburner
ICQ
Paypal
Button Blue
Button White
Bing
WordPress (blue)
Metacafe
Heart
Button Orange
Button Light Blue Button Yellow
Meetup
Drupal
Yelp
Star
Green
Welcome
Program At-A-Glance
Hotel Information
Continuing Medical Education (CME) Information
Continuing Professional Education (CPE) Information
Continuing Education Contact Hours (CECH) in Health Education Information
Claiming CME, CPE, and CECH Credit
Conference Program
Poster Abstracts
Exhibits Guide
Upcoming ASN Education and Professional Development Activities
Table of Contents
3
4
5
6
9
9
9
30
7–8
10–11
12–27
28–29
Connie Bales, Ph.D., R.D.Duke University, Center for the Study of Aging and Human Development Mary Ann Johnson, Ph.D.University of Georgia, Dept. of Food and Nutrition Nancy Krebs, M.D.University of Colorado, Dept. of Pediatrics
Penny Kris-Etherton, Ph.D., R.D.Pennsylvania State University,Dept of Nutritional Sciences Robert Kushner, M.D., M.S.Northwestern University, Feinberg School of Medicine Susan B. Roberts, Ph.D.Tufts University, Jean Mayer USDA/HNRC—Senior Scientist and Director
Edward Saltzman, M.D.Tufts University, Jean Mayer USDA Human Nutrition Research Center Steven R. Smith, M.D.Louisiana State University,Pennington Biomedical Research Center Thomas R. Ziegler, M.D.Emory University Hospital,Diabetes, Endocrinology & Metabolism and Internal Medicine
PROGRAM COMMIT TEE
Appreciation is extended to the volunteer leadership of the Medical Nutrition Council (MNC), listed below. The Program Committee conducted a thorough peer review of this session modeled after the ASN Scientific Program Committee review for ASN’s scientific sessions. The group also took steps to ensure that the session would meet established criteria for continuing medical education (CME), continuing professional education (CPE) credit, and continuing education contact hours (CECH) in health education.
Welcome
Dear Attendee:
The American Society for Nutrition (ASN) welcomes you to this special conference: Advances and Controversies in Clinical Nutrition. ASN is the authoritative voice on nutrition, and publisher of The American Journal of Clinical Nutrition, The Journal of Nutrition, and Advances in Nutrition reviews journal. Established in 1928, ASN’s 4,000 members in more than 75 countries work in academia, practice, government and industry. Members benefit from savings on professional development and continuing education credit, as well as critical public information efforts that inform Congress, federal agencies, media and consumers. ASN advances excellence in nutrition research and practice through its publications, education, public affairs and membership programs.
ASN offers numerous programs specifically for clinicians and allied health professionals. Rely on ASN to stay up to date on the latest research and practice implications that may affect your treatment of patients. Join ASN if you haven’t already, and subscribe to our special electronic newsletter, Medical Nutrition News. You will also benefit from our advocacy agenda to support clinicians. Finally, don’t miss the clinical symposia at ASN’s Scientific Sessions and Annual Meeting at Experimental Biology, April 9-13, 2011 (for more information, please visit www.nutrition.org/meetings/annual). We thank you for attending our new conference: Advances and Controversies in Clinical Nutrition. This meeting is organized by ASN’s Medical Nutrition Council and will feature expert speakers in areas like Dietary Supplements; Obesity, Diet and Disease; and Nutrition, Diet and Aging.
We hope that you enjoy the science presented during this conference.
4
About the ConferenceThis conference, organized by the ASN Medical Nutrition Council (MNC), is designed for health professionals with an interest in clinical nutrition. This program will feature expert speakers in areas like Dietary Supplements; Obesity, Diet and Disease; and Nutrition, Diet and Aging. Attendees may earn up to 14 hours of continuing education credits. This conference is geared towards health care professionals with an interest in clinical nutrition as it relates to obesity, aging, diabetes and chronic disease therapy and prevention, and more.
WWW.AJCN.ORGISSN 0002-9165
SLAIROTIDE Aging at home: more research on nutrition and independence,
please. NS Wellman See corresponding article on page 1204. 1151
Does global hypomethylation contribute to susceptibility
to neural tube defects? RH Finnell et al See corresponding article on page 1359.
1153 Is risk of Alzheimer disease a reason to use dietary
supplements? J Dwyer and MD Donoghue See corresponding article on page 1402.
1155 ORIGINAL RESEARCH COMMUNICATIONS Obesity and eating disorders Effect of conjugated linoleic acid on body fat accretion in
overweight or obese children. NM Racine et al 1157
Body mass index patterns over 5 y in obese children
motivated to participate in a 1-y lifestyle intervention:
age as a predictor of long-term success. T Reinehr et al
1165 Nature and nurture in infant appetite: analysis of the Gemini
twin birth cohort. CH Llewellyn et al
1172 Lipids
Antioxidant-rich spice added to hamburger meat during
cooking results in reduced meat, plasma, and urine
malondialdehyde concentrations. Z Li et al 1180
v -3 Fatty acid supplements in women at high risk of breast
cancer have dose-dependent effects on breast adipose
tissue fatty acid composition. LD Yee et al 1185
Serum n − 6 fatty acids and lipoprotein subclasses in
middle-aged men: the population-based cross-sectional
ERA-JUMP Study. J Choo et al
1195 Cardiovascular disease risk The effect of home-delivered Dietary Approach to Stop
Hypertension (DASH) meals on the diets of older adults
with cardiovascular disease. JL Troyer et al See corresponding editorial on page 1151.
1204 Micronutrient concentrations and subclinical atherosclerosis
in adults with HIV. EL Falcone et al
1213
A diet based on high-heat-treated foods promotes risk
factors for diabetes mellitus and cardiovascular diseases. I Birlouez-Aragon et al
1220
Nutritional status, dietary intake, and body composition
Rapid loss of appendicular skeletal muscle mass is
associated with higher all-cause mortality in older men:
the prospective MINOS study. P Szulc et al 1227
Eating vegetables first: the use of portion size to increase
vegetable intake in preschool children. MK Spill et al 1237 Energy and protein metabolism Validation of predictive equations for resting energy
expenditure in obese adolescents. GH Hofsteenge et al 1244 Vitamins, minerals, and phytochemicals Randomized trial of vitamin D supplementation to prevent
seasonal influenza A in schoolchildren. M Urashima et al 1255 Nutritional support L -Arginine supplementation improves exercise capacity
after a heart transplant. S Doutreleau et al 1261
Cancer Multivitamin use and breast cancer incidence in a prospective
cohort of Swedish women. SC Larsson et al 1268
Aging Associations between diet, lifestyle factors, and telomere
length in women. A Cassidy et al
1273
Nutritional epidemiology and public health Dietary glycemic index and load in relation to risk of uterine
leiomyomata in the Black Women’s Health Study. RG Radin et al
1281 Gastric cancer and salt preference: a population-based
cohort study in Korea. J Kim et al
1289
Dietary patterns and breast cancer risk: a systematic review
and meta-analysis. SF Brennan et al
1294
Are dietary choline and betaine intakes determinants of total
homocysteine concentration? JE Lee et al 1303
Is protein intake associated with bone mineral density in
young women? JM Beasley et al
1311 Continued on Table of Contents inside
SUPPLEMENTS Micronutrient Bioavailability: Priorities and Challenges
for Setting Dietary Reference Values 1413S
National Conference on Childhood Obesity 1493S
A Publication of the American Societyfor Nutrition
MAY
2010
The Am
erican Journal of CLIN
ICA
L NU
TRITIO
NV
OLU
ME
91N
UM
BE
R 5
PAG
ES
1151–1538
24th Annual International Conference on Practical Approaches to the Treatment of ObesityJune 17 - 19, 2010 • Royal Sonesta Hotel • Cambridge, MAAs health care professionals, we are faced everyday with the medical conse-
quences of poor nutrition, inadequate physical activity and obesity. In order to
meet these challenges, we must stay up-to-date with the rapidly evolving sci-
ence in the field of obesity medicine which is giving new insights into effective
approaches to the management of obesity. To register or for more information please visitwww.cme.hms.harvard.edu/courses/practical or contact:George L. Blackburn, M.D., Ph.D.Beth Israel Deaconess Medical Center330 Brookline Avenue, Feldberg 880, Boston, MA 02215
Telephone: (617) 667-2603 Facsimile:(617) 667-2685Email: [email protected]
Recruiters: Don’t miss thisimportant message!TO: Recruiters wanting to promote open positions,fellowship opportunities, programs, or conferenceannouncements.TIME: Now
MESSAGE: The Journal of Nutrition and TheAmerican Journal of Clinical Nutrition are theperfect way to advertise to research scientists,physicians, & registered dieticians. And now thefull issues of each journal are made availableonline in a pdf format. So your ad gets additionalexposure online for free. Also, frequency discountsare given for running ads in both journals.NOTE: Quarter, half, and full page ad sizes are
available. Issues close the first of the month pre-ceding the issue month.ACTION REQUESTED: Email your ad [email protected] for a quote.Contact FASEB AdNet at 301-634-7791. View fullmedia kit at www.faseb.org/adnet.
Notice of Availability of Vitamin D Standard Reference Material Available on: April 15, 2009
NIH Office of Dietary Supplements and the National Institute of Standards and Technology (NIST)
The National Institute of Standards and Technology (NIST) has worked with the National Institutes of Health’s Office of
Dietary Supplements to develop a standard reference material (SRM) for circulating vitamin D analysis. This reference
material, SRM 972 Vitamin D in Human Serum, consists of four pools of fresh-frozen serum. Each pool has a different level
of 25(OH)D2, 25(OH)D3, or both. One pool also contains 3-epi-25(OH)D3. The SRM will provide a material with stable,
well-defined levels of the analytes of interest. It will serve as a reproducible point of comparison, of results across laboratories
and within a given laboratory over time. Investigators can use the SRM to validate new analytical methods as they are
developed and to assign values to in-house quality-control materials.
Investigators also have the opportunity to participate in an ODS-funded NIST quality assurance program for analysis of
vitamin D metabolites in human serum (e.g., 25(OH)D2 and 25(OH)D3): Participation in this quality assurance program will
demonstrate your laboratory’s proficiency for assessment of vitamin D status. As such, it adds to the credibility of your study
results. There will be no fee for participation (nor will study participants be paid to participate). NIST chemometricians will
compile data and provide you with confidential feedback regarding your laboratory’s performance relative to expected values.
Also available from NIST is the new SRM 3280 for multivitamin/multielement tablets. This will be of value to manufacturers
and clinical trialists who currently have no definitive, independently certified standard with which to verify their testing
methods and calibrate their equipment.
Inquiries: Karen Phinney, Ph.D. National Institute of Standards and Technology
Phone: 301-975-4457; e-mail: [email protected]
Program At-A-Glance
5
Friday, February 25Registration: 10:00 a.m. – 6:00 p.m.Exhibits: 1:00 – 4:15 pm
2:00–2:40 pmFortification vs. SupplementationJ. F. GregoryCyril Magnin Ballroom
2:40–3:20 pmAssessing and Managing Vitamin D Deficiency V. Tangpricha Cyril Magnin Ballroom
3:20–4:00 pmVitamin D and Chronic DiseaseA. G. PittasCyril Magnin Ballroom
4:00–4:15 pmBreak
4:15–4:55 pmFolate and Cancer Risk: A Complex Relationship: Two Points of ViewJ.B. MasonP. J. Stover Cyril Magnin Ballroom
4:55–5:35 pmDietary Supplements: Who Needs Them and When Are They Needed?R. M. Russell Cyril Magnin Ballroom
5:35–6:05 pmIssues in the Use of Herbal Dietary SupplementsP. M. CoatesCyril Magnin Ballroom
6:05–7:30 pmPoster ReceptionEmbarcadero
Saturday, February 26Registration: 7:00 a.m. – 6:00 p.m.Exhibits: 9:30 am – 3:25 pm
8:00–8:40 amSodium and CVD: Two Points of ViewM. AldermanG. ChertowCyril Magnin Ballroom
8:40–9:20 amIs a Calorie a Calorie?S.B. Roberts Cyril Magnin Ballroom
9:20–10:00 amNutrition Management of the Bariatric PatientE. SaltzmanCyril Magnin Ballroom
10:00–10:15 amBreak
10:15–11:05 amThe Role of Dietary Fat in CVD: Two Points of ViewE. J. Schaefer M. Pereira Cyril Magnin Ballroom
11:05–11:55 amBrain Nutrient Sensing and Disease R. J. SeeleCyril Magnin Ballroom
11:55 am–12:35 pmThe Microbiome: Should We Modify It?J. B. GermanCyril Magnin Ballroom
12:35–1:45 pmLunch on your own
1:45–2:25 pmThe Benefits and Risks of Calcium SupplementationJ. A. Baron Cyril Magnin Ballroom
2:25–3:05 pmThe Role of Diet in Atopic and Inflammatory DiseaseD. HeberCyril Magnin Ballroom
3:05–3:25 pmBreak
3:25–4:05 pmEnergy Density and Energy Balance: Questions on Causation and RecommendationsR.D. MattesCyril Magnin Ballroom
4:05–4:50 pmWorkshops: Assessing Micronutrient
Deficiencies D. Seidner Powell Room
Feeding the Hospitalized or Institutionalized Patient T.R. Ziegler Cyril Magnin Ballroom III
Nutrition Management: Bariatric Surgery Patient M. Furtado Market Street Room
5:15–6:45 pmPoster ReceptionEmbarcadero
Sunday, February 27Registration: 7:00 – 11:00 a.m.
8:00–8:40 amImpact of Caloric Restriction on Biomarkers of AgingE. RavussinCyril Magnin Ballroom 8:40–9:20 amDoes it Matter to Your Aging Brain What You Eat?J.W. MillerCyril Magnin Ballroom
9:20–10:00 amNutrition Interventions to Prevent Muscle LossK. Sreejumaran NairCyril Magnin Ballroom
10:00–10:20 amBreak
10:20–11:05 amWorkshops: Techniques for Effective
Nutrition Behavior Change D.H. Bessesen Cyril Magnin Ballroom III Medical Nutrition Therapy in Diabetes J. Wylie–Rosett Powell Room
11:05 am–12:05 pmDietary Recommendations and Age: At What Point Do You Stop Caring About Diet Composition? Two Points of ViewD.K. HoustonJ. E. MorleyCyril Magnin Ballroom
12:05 pmConference Ends
WWW.AJCN.ORG
ISSN 0002-9165
SLAIROTIDE Aging at home: more research on nutrition and independence,
please. NS Wellman See corresponding article on page 1204. 1151
Does global hypomethylation contribute to susceptibility
to neural tube defects? RH Finnell et al See corresponding article on page 1359.
1153 Is risk of Alzheimer disease a reason to use dietary
supplements? J Dwyer and MD Donoghue See corresponding article on page 1402.
1155 ORIGINAL RESEARCH COMMUNICATIONS Obesity and eating disorders Effect of conjugated linoleic acid on body fat accretion in
overweight or obese children. NM Racine et al 1157
Body mass index patterns over 5 y in obese children
motivated to participate in a 1-y lifestyle intervention:
age as a predictor of long-term success. T Reinehr et al
1165 Nature and nurture in infant appetite: analysis of the Gemini
twin birth cohort. CH Llewellyn et al
1172 Lipids
Antioxidant-rich spice added to hamburger meat during
cooking results in reduced meat, plasma, and urine
malondialdehyde concentrations. Z Li et al 1180
v -3 Fatty acid supplements in women at high risk of breast
cancer have dose-dependent effects on breast adipose
tissue fatty acid composition. LD Yee et al 1185
Serum n − 6 fatty acids and lipoprotein subclasses in
middle-aged men: the population-based cross-sectional
ERA-JUMP Study. J Choo et al
1195 Cardiovascular disease risk The effect of home-delivered Dietary Approach to Stop
Hypertension (DASH) meals on the diets of older adults
with cardiovascular disease. JL Troyer et al See corresponding editorial on page 1151.
1204 Micronutrient concentrations and subclinical atherosclerosis
in adults with HIV. EL Falcone et al
1213
A diet based on high-heat-treated foods promotes risk
factors for diabetes mellitus and cardiovascular diseases. I Birlouez-Aragon et al
1220
Nutritional status, dietary intake, and body composition
Rapid loss of appendicular skeletal muscle mass is
associated with higher all-cause mortality in older men:
the prospective MINOS study. P Szulc et al 1227
Eating vegetables first: the use of portion size to increase
vegetable intake in preschool children. MK Spill et al 1237 Energy and protein metabolism Validation of predictive equations for resting energy
expenditure in obese adolescents. GH Hofsteenge et al 1244 Vitamins, minerals, and phytochemicals Randomized trial of vitamin D supplementation to prevent
seasonal influenza A in schoolchildren. M Urashima et al 1255 Nutritional support L -Arginine supplementation improves exercise capacity
after a heart transplant. S Doutreleau et al 1261
Cancer Multivitamin use and breast cancer incidence in a prospective
cohort of Swedish women. SC Larsson et al 1268
Aging Associations between diet, lifestyle factors, and telomere
length in women. A Cassidy et al
1273
Nutritional epidemiology and public health Dietary glycemic index and load in relation to risk of uterine
leiomyomata in the Black Women’s Health Study. RG Radin et al
1281 Gastric cancer and salt preference: a population-based
cohort study in Korea. J Kim et al
1289
Dietary patterns and breast cancer risk: a systematic review
and meta-analysis. SF Brennan et al
1294
Are dietary choline and betaine intakes determinants of total
homocysteine concentration? JE Lee et al 1303
Is protein intake associated with bone mineral density in
young women? JM Beasley et al
1311 Continued on Table of Contents inside
SUPPLEMENTS Micronutrient Bioavailability: Priorities and Challenges
for Setting Dietary Reference Values 1413S
National Conference on Childhood Obesity 1493S
A Publication of the American Societyfor Nutrition
MAY
2010
The Am
erican Journal of CLIN
ICA
L NU
TRITIO
NV
OLU
ME
91N
UM
BE
R 5
PAG
ES
1151–1538
24th Annual International Conference on Practical Approaches to the Treatment of ObesityJune 17 - 19, 2010 • Royal Sonesta Hotel • Cambridge, MAAs health care professionals, we are faced everyday with the medical conse-
quences of poor nutrition, inadequate physical activity and obesity. In order to
meet these challenges, we must stay up-to-date with the rapidly evolving sci-
ence in the field of obesity medicine which is giving new insights into effective
approaches to the management of obesity. To register or for more information please visitwww.cme.hms.harvard.edu/courses/practical or contact:George L. Blackburn, M.D., Ph.D.Beth Israel Deaconess Medical Center330 Brookline Avenue, Feldberg 880, Boston, MA 02215
Telephone: (617) 667-2603 Facsimile:(617) 667-2685Email: [email protected]
Recruiters: Don’t miss thisimportant message!TO: Recruiters wanting to promote open positions,fellowship opportunities, programs, or conferenceannouncements.TIME: Now
MESSAGE: The Journal of Nutrition and TheAmerican Journal of Clinical Nutrition are theperfect way to advertise to research scientists,physicians, & registered dieticians. And now thefull issues of each journal are made availableonline in a pdf format. So your ad gets additionalexposure online for free. Also, frequency discountsare given for running ads in both journals.NOTE: Quarter, half, and full page ad sizes are
available. Issues close the first of the month pre-ceding the issue month.ACTION REQUESTED: Email your ad [email protected] for a quote.Contact FASEB AdNet at 301-634-7791. View fullmedia kit at www.faseb.org/adnet.
Notice of Availability of Vitamin D Standard Reference Material Available on: April 15, 2009
NIH Office of Dietary Supplements and the National Institute of Standards and Technology (NIST)
The National Institute of Standards and Technology (NIST) has worked with the National Institutes of Health’s Office of
Dietary Supplements to develop a standard reference material (SRM) for circulating vitamin D analysis. This reference
material, SRM 972 Vitamin D in Human Serum, consists of four pools of fresh-frozen serum. Each pool has a different level
of 25(OH)D2, 25(OH)D3, or both. One pool also contains 3-epi-25(OH)D3. The SRM will provide a material with stable,
well-defined levels of the analytes of interest. It will serve as a reproducible point of comparison, of results across laboratories
and within a given laboratory over time. Investigators can use the SRM to validate new analytical methods as they are
developed and to assign values to in-house quality-control materials.
Investigators also have the opportunity to participate in an ODS-funded NIST quality assurance program for analysis of
vitamin D metabolites in human serum (e.g., 25(OH)D2 and 25(OH)D3): Participation in this quality assurance program will
demonstrate your laboratory’s proficiency for assessment of vitamin D status. As such, it adds to the credibility of your study
results. There will be no fee for participation (nor will study participants be paid to participate). NIST chemometricians will
compile data and provide you with confidential feedback regarding your laboratory’s performance relative to expected values.
Also available from NIST is the new SRM 3280 for multivitamin/multielement tablets. This will be of value to manufacturers
and clinical trialists who currently have no definitive, independently certified standard with which to verify their testing
methods and calibrate their equipment.
Inquiries: Karen Phinney, Ph.D. National Institute of Standards and Technology
Phone: 301-975-4457; e-mail: [email protected]
Hotel Information
6
!"#"!$%&'""$
!""#$%&'())*'
'
!"#$%&"'%(
(
)*+,-$(
.''/,0$(
1$"2"%0(
3$"04/(
(
12,&&-''#(
!"#$%&#'()(
12,&&-''#(
!*#$%&#'()(
1'%5$-$%6$(
(
3'22'7(
)*+,-$(
8$6$9/"'%(
(
8'+%:&(
(
;4$,/$-(
(
<=
)4,9$(
(
+*,-./-0".)' +,(-',(( >?@A@( '(,./( BA@( CBC( >@( A@( DE>( FG@( F@@( >@(
!-.1"#'2#.""#' D@(-+D(( C?EA@( '(,./( E@( BC@( DD( DH( F@@( CB@( CC@( D@(
!-3)%' C>(-0*(( A@@( '(,./( CC( CH( C@( CC( D@( D@( >@( C@(
4)5"66' 0*(-*1(( B?B@D( '(,./( FA( DH( FC( D@( H@( H@( BC@( FC(
4)5"66'7' 0*(-0"(( >>C( '(,./( CD( FC( C@( CC( F@( D@( A@( C@(
4)5"66'77' 0*(-0"(( >>C( '(,./( CD( FC( C@( CC( F@( D@( A@( C@(
8+9+8':;(++''
!"#$%&'()*+,"+-'%,+.+/.(%),0+"$+)/)#,-1+2)/)2+,3())4-+,5"+6'#%"(+7.22(""8-+"$$)(+$2)9%72)+.#*++++++++++++++++++++++++++
<=7><+'9+=<+2?''8@(A+'B7=CDB2'DEE+('=@:<(@8'87A;:7=A?''2!@88+('2+227D='(DD!2'@(+'7C+@8':D'2+8EFGD=:@7=+C'
4(DA(@!2?''4(+FE<=G:7D='@(+@2'H+:B++='!@(I+:'2:(++:'@=C'+!H@(G@C+(D'DEE+('@'=@:<(@8'H(7CA+'ED('
GD=9+=7+=:'E8DBJ'(+A72:(@:7D='@=C'+K;7H7:2'D9+(8DDI7=A':;+'@:(7<!?'
(
I#J,-6,:$-'(
),2$&?(1,/$-"%0(K(
1'%L$%/"'%(
)$-L"6$&(
((((((M/-"+#( N,-O$/()/-$$/(
!-3)%'P'7$22(
QQ(
P'7$22(((((
Q(
!"#"!$%&'($
!""#$%&'())*''
!"#$%&"'%(
(
)*+,-$(
.''/,0$(
1$"2"%0(
3$"04/(
(
12,&&-''#(
!"#$%&#'()(
12,&&-''#(
!*#$%&#'()(
1'%5$-$%6$(
(
3'22'7(
)*+,-$(
8$6$9/"'%(
(
8'+%:&(
(
;4$,/$-(
(
<=
)4,9$(
(
+,-$.'!/&%$%'0/..-))*'
++(,-."(( >?@AB( -/(01( CB>( DEB( FBB( GB( FBBB( EEB( >BB( HB(
+,-$.'!/&%$%'1' ++(,"*(( F?GHB( -/(01( AB( FBE( EE( >C( DBB( F>B( FA>( E@(
+,-$.'!/&%$%'11' ++(,"+(( F?HC>( -/(01( AB( FBE( EE( >C( DBB( F>B( FA>( E@(
+,-$.'!/&%$%'111' ++(,"*(( F?GHB( -/(01( AB( FBE( EE( >C( DBB( F>B( FA>( E@(
+,-$.'!/&%$%'2),"-3' +2(,-/.(( @?GEB( -/(.1( ( ( ( ( FCBB( DAB( ( (
0/.4)/' //(,/+(( >>B( '(-.1( CF( CG( CB( CC( >B( EB( E>( CB(
5/6$78)%' //(,/+(( >>B( '(-.1( CF( CG( CB( CC( >B( EB( E>( CB(
2$..*)-"' -3(,"-(( >GH( '(-.1( CF( CG( CE( CB( >B( EB( E>( CB(
9"/-8#' -3(,"2(( ABD( '(-.1( FG( CE( CG( CB( @B( EB( E>( CB(
:)*4/-7' -*(,"2(( >FG( '(-.1( F>( CB( CE( CB( EB( DB( EB( CB(
;#)<=#)%' DB(,/.(( @BB( '(-.1( CE( DC( CC( CC( >B( >B( DB( CC(
!$88$)%' /*(,2-(( F?ABE( '(-.1( A>( FBB( EE( >E( CBB( FBB( FEB( E@(
!$88$)%'1' /*(,"-(( AEE( '(-.1( DB( EB( CC( CC( A>( EB( @B( CC(
!$88$)%'11' /*(,/+(( @BB( '(-.1( CE( DC( CB( CC( >B( EB( >B( CB(
!$88$)%'111' /*(,-+(( D@B( '(-.1( FC( F@( CB( F@( CE( CB( CE( CB(
!"#"$%&%'()*+),+)%,$-.*')".*%+)/%(."-0)1+&"-)(2."3')4++&"5')+4)!63%-)7"5,%,)8+6'3)%()9:;<=)%,$-.*%,5)"--)(.33+.,*%,5)#3'>4.,$&%+,0(
)/'6I/'%(
J"&&"'
%(K(
J"&&"'
%(KK(
J"&&"'
%(KKK(
L'#
M,
-:(
3$
,-&
/(."22#
'-$
(
(
!,N":&'%((
O,2M',(
1P-"2(
J,0%"%(KKK(
1P-"2(
J,0%"%(KK(
1P-"2(
J,0%"%(K(
1P-"2((J,0%"%(
.'P$-(
O+&"%$&&(
1$%/$-(
Q'
#$
%(
J$
%(
:>?>:'2@A(''
2@(!'!>>B;'2AC+B1@C'1C'D'?D(1>BE'@2';FD+>;'2@('1CB1!DB>'>?>CB;'@('G(DC5'GD:D;'@C'B9>'2@A(B9':>?>:H''''''''''''''''''
5I+@(J':1G9B1CG'DC5';FD+>'2:@K'1;'5>;1GC>5'B@'>LF(>;;'B9>'D!01DC+>'@2'!"#$%&"#'(!')*!$%"+),!'
;B(>>B;'DC5'@22>('D'AC1MA>'0D+N5(@FH''B9>'>LFDC;1?>'2@E>('DC5';!D::>(';>;;1@C';FD+>;'@22>(':D(G>'K1C5@K;'
@?>(:@@N1CG'B9>'+1BE;+DF>H
8$0"&/-,/"'%(
L E V E L T H R E E
L E V E L F O U R
Wyndham Parc 55 • 55 Cyril Magnin Street • (415) 392-8000
Continuing Medical Education (CME)
7
CME SponsorshipThis educational activity is jointly sponsored by the University of Maryland School Of Medicine and the American Society for Nutrition.
OverviewThe American Society for Nutrition (ASN) is dedicated to bringing together the world’s top researchers, clinicians and industry to advance our knowledge of nutrition. This meeting is organized by ASN’s Medical Nutrition Council and will feature expert speakers in areas like Dietary Supplements; Obesity, Diet and Disease; and Nutrition, Diet and Aging. This meeting presents an opportunity to get a good understanding of some of the controversial areas of nutrition and to hear both sides.
Target AudienceThis educational activity is designed for physicians, dietitians, health educators and other professionals involved in treatment and prevention with clinical nutrition.
Learning ObjectivesUpon completion of this educational activity, participants should be able to describe and discuss:• Nutrition and medical management of patients with
obesity and chronic disease• Impact of dietary supplements for patients with
chronic disease • How diet impacts the aging process• How to interpret research to design medical
approach, diet, and behavior modification for patients of various ages and health
• What constitutes a healthy diet for all and use this information to develop programs for patients
Accreditation StatementThis activity has been planned and implemented in accordance with the Essential Areas and Policies of the Accreditation Council for Continuing Medical Education through the joint sponsorship of the University of Maryland School of Medicine and the American Society for Nutrition. The University of Maryland School of Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.
Credit Designation StatementThe University of Maryland School of Medicine designates this educational activity for a maximum of 14.50 AMA PRA Category 1 Credits™. Physicians should only claim credit commensurate with the extent of their participation in the activity.
DisclosureIt is the policy of the University of Maryland School of Medicine to ensure balance, independence, objectivity, and scientific rigor in all of its educational activities. In accordance with this policy, all persons in a position to control activity content of continuing medical education activities must disclose their financial relationships with commercial interests relevant to the content of the CME activity. Any conflicts of interest identified must be resolved prior to presentation of the educational activity.
Americans With Disabilities ActIf you require special accommodations to attend or participate in the CME activity, please provide information about your requirements to Katrina Dunn at 310-634-7043 or (1-800-735-2258 TTY/voice) at least five business days in advance of the activity.
Discussion of Off-Label or Investigational UsesPresentations in this continuing medical education activity may contain references to unlabeled or unapproved uses of drugs or devices. The audience is advised to consult the full prescribing information of all drugs or devices prior to use. Some drugs/devices identified during this activity may have United States Food and Drug Administration (FDA) clearance for specific purposes only or for use in restricted research settings. The FDA has stated that it is the responsibility of the individual physician to determine the FDA status of each drug or device that he/she wishes to use in clinical practice and to use the products in compliance with the applicable law.
UMSOM requires that all contributors disclose any unlabeled use or investigational use (not yet approved for any purpose) of pharmaceutical and medical device products and provide adequate scientific and clinical justification for such use. Physicians are urged to fully review all the available data on products or procedures before using them to treat patients.
Continuing Medical Education (CME)
8
DisclaimerThis CME activity is designed for use by healthcare professionals for educational purposes only. Information and opinions offered by the contributors represent their viewpoints. Conclusions drawn by the participant should be derived from careful consideration of all available scientific information. Prescription information and use of medical devices should be undertaken only after confirmation of information by consulting the FDA-approved uses and information.
While UMSOM makes every effort to have accurate information presented, no warranty, expressed or implied, is offered. The participant should use his/her clinical judgment, knowledge, experience, and diagnostic decision-making before applying any information, whether provided here or by others.
Acknowledgement of SupportThe following institutions, organizations, and companies have provided educational grants in support of the Advances and Controversies in Clinical Nutrition as of press time:
John A. Baron, MDOther Financial or Material Support: Wyeth (now Pfizer) has licensed a use patent for calcium as a chemo preventive agent held by Dartmouth and me (for Polyp Prevention Study Group)
J. Bruce German, PhDGrants/Research Support: DSM, Unilever, Prolacta, Nestle, AgilentConsultant: Nestle, Tethys, DMI, Physic Ventures
Denise K. Houston, PhD.Grants/Research Support: MerckOther Financial or Material Support/Honorarium: Abbott Nutrition Health Institute, Abbott Laboratories
Penny M. Kris-Etherton, PhD, RDGrants/Research Support: National Cattelman’s Beef Association, California Walnut Commission, The Peanut Institute, General Mills, Almond Board of California, Western Pistachio AssociationConsultant: Monavic, Unilever
Joshua W. Miller, PhDGrants/Research Support: Vitalea ScienceConsultant: Strativa Pharmaceuticals
John E. Morley, MDGrants/Research Support: Cardiokine, Danone, Nestle and NumicoConsultant: Amgen, Cytokinetics, Edunn Biotec, GlaxoSmithKline, Healthspan, Incyte, Lilly, LCC, Mattern Pharmaceuticals, Sanofi-AventisSpeakers Bureau: Amgen, Mattern, Healthspan
Stock Shareholder: Mattern Pharmaceuticals, Edunn BiotecEric Ravussin, PhD, PDrGrants/Research Support: NIH, EthiconConsultant: BMS, Amylin, Eli Lilly, Ethicon, MerckOther Financial or Material Support/Honorarium: Amylin, Eli Lilly BMS
Ernst J. Schaefer, MDGrants/Research Support: DuPont, Resverlogix, UnileverConsultant: Arisaph, DuPont, Merck, Roche, UnileverStock Shareholder: Boston Heart Laboaratory
Randy J. Seeley, PhDGrants/Research Support: Johnson & Johnson, Roche, AmylinConsultant: Johnson & Johnson, Roche, Lilly, Merck, Novo Nordisk, AlkermesStock Shareholder: ZafgenOther Financial or Material Support/Honorarium: Merck
Douglas Seidner, MDGrants/Research Support: NPS PharmaceuticalsConsultant: Abbott
Steven R. Smith, MDConsultant: Amylin, Lilly, AstraZeneca, Orexigen, Five Prime, Avena
Vin Tangpricha, MD, PhDGrants/Research Support: Genzyme, Amgen, Novartis
Judith Wylie-Rosett, EdD, RDGrants/Research Support: Provident, Inc. as subcontractor of Kraft, Inc.Consultant: AbbottOther Financial or Material Support/Honorarium: Honorarium Review Unilever, Monsanto
The following individuals have disclosed financial relationships with commercial interests:
• Almond Board of California
• American Institute for Cancer Research
• Bariatrix Nutrition Corp.• California Walnut Board• Corn Refiners Association• Dyets, Inc.• Kraft Foods
• NIH Office of Dietary Supplements
• PepsiCo• Proliant Health and
Biologicals• Solae• Tomato Wellness Council• U.S. Food & Drug
Administration
The following individuals have disclosed no financial relationships with commercial interests: Michael Alderman, MDDaniel H. Bessesen, MDConnie W. Bales, PhD, RDGlenn Chertow, MDPaul M. Coates, PhDMargaret Furtado, MS, RD, LDNJesse F. Gregory, PhDDavid Heber, MD, PhDMary Ann Johnson, MDNancy F. Krebs, MDRobert Kushner, MD
Joel B. Mason, MDRichard D. Mattes, MPH, PhD, RDK. Sreekumaran Nair, MD, PhDMark A. Pereira, PhDAnastassios G. Pittas, MD, MSSusan B. Roberts, PhDRobert M. Russell, MDEdward Saltzman, MDNanette Steinle, MDPatrick Stover, PhDThomas Ziegler, MD
Continuing Professional Education (CPE) and Continuing Education Contact Hours (CECH) in Health Education Statements
9
CPE Accreditation Statement ASN (Provider #NS010) is accredited and approved by the Commission on Dietetic Registration (CDR) as a provider of Continuing Professional Education (CPE) programs for Registered Dietitians.
CPE Credit Designation Statement ASN designates this educational activity for a maximum of 14 CPEUs. Dietitians and dietetic technicians, registered should only claim credit commensurate with the extent of their participation in the activity.
Learning Level 2
Suggested Learning Codes: 2000, 2020, 2070, 2090, 3000, 3070, 4120, 4170, 4180, 4190, 5000, 5070, 5090, 5100, 5150, 5160, 5190, 5300, 5370, 5440, 6000, 6010, 9020
Other Continuing Education CECH Credit Designation StatementThe Advances and Controversies in Clinical Nutrition conference has been approved for 13 Category 1 continuing education contact hours (CECH) in health education by the National Commission for Health Education Credentialing.
Other Continuing Education Credit and Letters of Participation If you are not a physician or dietitian and seek continuing education credit or require a letter confirming your participation, please contact us. You may contact Moira Holt at [email protected] with these inquiries.
H OW TO C L A I M C M E, C P E A N D C E C H C R E D I T In order to claim credit, activity participants must:
Sign in onsite at the Continuing Education/ Conference Registration desk, and
Complete an online program evaluation in order to be awarded AMA PRA Category 1 Credits™, Continuing Professional Education (CPE) credit and/or Continuing Education Contact Hours (CECH). After the conference, a link to complete the online program evaluation will be sent to the email address you used to register for the conference.
There are no fees for continuing education processing.
Questions about CME credit should be directed to Althea Pusateri, Office of Faculty Affairs and Professional Development, University of Maryland School of Medicine, at [email protected] or 410-706-3957.
Questions about CPE and CECH credit should be directed to Moira Holt at the American Society for Nutrition (ASN) at [email protected] or 301-634-7077.
2
1
E VA L U AT I O N M U S T B E C O M P L E T E D N O L AT E R T H A N A U G U S T 2 5 , 2 0 1 1T O C L A I M C R E D I T S A l l ow 2 – 3 we e k s fo r p ro ce s s i n g
Conference Program
1 0
H O U R S & C H E C K - I N T I M E SC O N F E R E N C E R E G I S T R AT I O N H O U R S : 7:00 am-6:00 pm C O N T I N U I N G E D U C AT I O N S I G N - I N : 7:00 am-6:00 pm E X H I B I T H O U R S : 9:30 am-3:25 pm, Cyril Magnin FoyerR O O M L O C AT I O N SA L L S E S S I O N S : Cyril Magnin BallroomALL REGISTRATIONS & SIGN-INS: Reg. Desk, Cyril Magnin Foyer W O R K S H O P S : Cyril Magnin Ballroom III, Market Street Room and
Powell Room, as noted below P O S T E R R E C E P T I O N : Embarcadero Room (3rd floor)
2:00-2:40 PmFortification vs. SupplementationJesse F. Gregory, PhD, Professor of Food Science and Human Nutrition, University of Florida
2:40-3:20 PmAssessing and Managing Vitamin D DeficiencyVin Tangpricha, MD, PhD, Associate Professor, Emory University School of Medicine
3:20-4:00 PmVitamin D and Chronic DiseaseAnastassios G. Pittas, MD, MS, Associate Director, Fellowship Program in Endocrinology, Diabetes and Metabolism, Co-Director, Diabetes Center, Tufts Medical Center
4:00-4:15 PmBreak
4:15-4:55 PmFolate and Cancer Risk: A Complex Relationship: Two Points of ViewJoel B. Mason, MD, Director, Vitamins and Carcinogenesis Laboratory, Tufts University, and Patrick J. Stover, PhD, Director of the Division of Nutritional Sciences, Cornell University
4:55-5:35 PmDietary Supplements: Who Needs Them and When Are They Needed?Robert M. Russell, MD, ASN President, Professor Emeritus of Medicine and Nutrition at Tufts University and Special Expert to the Office of Dietary Supplements (ODS) at NIH
5:35-6:05 PmIssues in the Use of Herbal Dietary SupplementsPaul M. Coates, PhD, Director, Office of Dietary Supplements, National Institutes of Health
6:05-7:30 PmPoster ReceptionEmbarcadero Room (3rd Floor)
8:00-8:40 AmSodium and CVD: Two Points of ViewMichael Alderman, MD, Professor of Epidemiology & Population Health, Albert Einstein College of Medicine, and Glenn Chertow, MD, Professor of Medicine, Stanford University
8:40-9:20 AmIs a Calorie a Calorie?Susan B. Roberts, PhD, Director, Energy Metabolism Laboratory, Tufts University
9:20-10:00 AmNutrition Management of the Bariatric PatientEdward Saltzman, MD, Scientist II, Energy Metabolism Laboratory, Tufts University
10:00-10:15 AmBreak
10:15-11:05 AmThe Role of Dietary Fat in CVD: Two Points of ViewErnst J. Schaefer, MD, Director, Lipid Metabolism Laboratory, Tufts University, and Mark Pereira, PhD, Associate Professor, University of Minnesota School of Public Health
11:05-11:55 AmBrain Nutrient Sensing and DiseaseRandy J. Seeley, PhD, Professor of Psychiatry and Associate Director of the Obesity Research Center, University of Cincinnati College of Medicine
11:55 Am-12:35 PmThe Microbiome: Should We Modify It?J. Bruce German, PhD, Professor, University of California, Davis
12:35-1:45 PmLunch on your own
Friday, February 25 Saturday, February 26
D I E T A R Y S U P P L E M E N T S O B E S I T Y , D I E T & D I S E A S E
H O U R S & C H E C K - I N T I M E SC O N F E R E N C E R E G I S T R AT I O N H O U R S : 10:00 am-6:00 pm C O N T I N U I N G E D U C AT I O N S I G N - I N : 10:00 am-6:00 pm P O S T E R P R E S E N T E R C H E C K - I N : 10:00 am-5:00 pmE X H I B I T H O U R S : 1:00-4:15 pm, Cyril Magnin FoyerR O O M L O C AT I O N SA L L S E S S I O N S : Cyril Magnin BallroomALL REGISTRATIONS & SIGN-INS: Reg. Desk, Cyril Magnin Foyer P O S T E R S E S S I O N S : Embarcadero Room (3rd floor)
Conference Program
1:45-2:25 PmThe Benefits and Risks of Calcium SupplementationJohn A. Baron, MD, Professor of Medicine and of Community and Family Medicine at Dartmouth College
2:25-3:05 PmThe Role of Diet in Atopic and Inflammatory DiseaseDavid Heber, MD, PhD, Director, UCLA Center for Human Nutrition
3:05-3:25 PmBreak
3:25-4:05 PmEnergy Density and Energy Balance: Questions on Causation and RecommendationsRichard D. Mattes, MPH, PhD, RD, Professor of Foods and Nutrition, Purdue University
4:05-4:50 PmWorkshops: Assessing Micronutrient DeficienciesDouglas Seidner, MD, Associate Professor of Medicine, Vanderbilt Center for Human Nutrition Powell Room (3rd Floor)
Feeding the Hospitalized or Institutionalized PatientThomas Ziegler, MD, Director, Emory Center for Clinical and Molecular Nutrition, Emory University HospitalCyril Magnin Ballroom III (4th Floor)
Nutrition Management: Bariatric Surgery PatientMargaret Furtado, MS, RD, LDN, Dietitian, John Hopkins Center for Bariatric SurgeryMarket Street Room (3rd Floor)
5:15-6:45 PmPoster ReceptionEmbarcadero Room (3rd Floor)
8:00-8:40 AmImpact of Caloric Restriction on Biomarkers of AgingEric Ravussin, PhD, PDr, Professor, Pennington Biomedical Research Center 8:40-9:20 AmDoes it Matter to Your Aging Brain What You Eat?Joshua W. Miller, PhD, Associate Professor in Residence, University of California, Davis
9:20-10:00 AmNutrition Interventions to Prevent Muscle LossK. Sreejumaran Nair, MD, PhD, Endocrinology Researcher, Mayo Clinic
10:00-10:20 AmBreak
10:20-11:05 AmWorkshops: Techniques for Effective Nutrition Behavior ChangeDaniel H. Bessesen, MD, Professor of Medicine, University of Colorado Health Science CenterCyril Magnin Ballroom III (4th Floor)
Medical Nutrition Therapy in DiabetesJudith Wylie-Rosett, EdD, RD, Head, Behavioral & Nutritional Research, Albert Einstein College of MedicinePowell Room (3rd Floor)
11:05 Am-12:05 PmDietary Recommendations and Age: At What Point Do You Stop Caring About Diet Composition? Two Points of ViewDenise K. Houston, PhD, RD, Assistant Professor of Internal Medicine, Wake Forest University, and John E. Morley, MD, Director, Division of Geriatric Medicine, Saint Louis University School of Medicine
12:05 PmConference Ends
1 1
Sunday, February 27
N U T R I T I O N , D I E T & A G I N G
Does Diet I nf luence the Aging Process?
H O U R S & C H E C K - I N T I M E SC O N F E R E N C E R E G I S T R AT I O N H O U R S : 7:00-11:00 amC O N T I N U I N G E D U C AT I O N S I G N - I N : 7:00 am-12:00 pm R O O M L O C AT I O N SA L L S E S S I O N S : Cyril Magnin BallroomW O R K S H O P S : Cyril Magnin Ballroom III and Powell Room,
as noted below
1 2
Combined Effects of Exercise Training and Red Ginseng 1. Supplementation on Lipid Profile, Aerobic Endurance, and Antioxidant Defense Capacity Si-Young Kim, College of Pharmacy, Seoul National University; Young-Soo Lee, Department of Physical Education, Sejong University, South Korea; and Young-Joon Surh, College of Pharmacy, Seoul National University Korean red ginseng (KRG), a heat-processed variety of Korean ginseng (Panax ginseng C.A. Meyer), has been reported to have various biological properties, but its combinational effects with exercise remain mostly unknown. The purpose of this study was to investigate the combined effects of regular exercise and KRG supplementation on the lipid profile (TC, TG, HDL, and LDL) and the anti-oxidant capacity (SOD, CAT, TAS, MDA, and 4-HNE) of human blood, and the effect of this combination on aerobic endurance (VO2max). Thirty-six males were randomized into control (CONT, n=9), KRG supplemented (KRG, n=9), exercise trained (EXT, n=9), and KRG supplemented and exercise trained (KET, n=9) groups. The KRG and KET group both took 4.5 grams/day of 100% KRG orally, while the CONT and EXT group both took an equal amount of lactose each day, for 12 weeks. The exercise trained groups participated in a structured aerobic exercise 3 days/week during the period. In the exercise and/or KRG treatment groups, the lipid profile improved significantly, relative to the CONT group. On the other hand, the increases in anti-oxidant capacity in the EXT and KRG groups were more pronounced than those observed in either the CONT group or the KET group. In addition, VO2max, the measurement for aerobic endurance, only increased significantly in the EXT group. Taking all these findings into account, although regular administration of KRG or exercise training for a 12- week period improves lipid profile, anti-oxidant capacity, and aerobic endurance, the combination of exercise and KRG may be less effective. This work was supported by Korea Ginseng Corporation (KGC).
Increased Hepatic Iron Stores by MRI in Chinese People 2. with Pre-diabetes or Type 2 Diabetes Xuan Zheng, Nutrition Department of Changhai Hospital; Tao Jiang, Clinical Imaging Department of Changzheng Hospital; Li Min3, Military Hygiene Department of the Second Military Medical University; Ling Changquan, Traditional Chinese Medicine Department of Changhai Hospital. Accumulating scientific evidence has indicated the relationship between increased iron store and higher risk of type 2 diabetes (T2DM). But previous studies mainly focused on ferritin which can reflect systemic inflammation coexisting with diabetes rather than high iron stores. Direct evidence to support the concept is still absent. To evaluate hepatic iron stores (HIS) in Chinese people with prediabetes or T2DM. MR gradient echo technique and T2* functional imaging were applied to evaluate HIS in 88 subjects (16 with normal glucose tolerance [NGT], 17 with prediabetes, and 55 with T2DM). Serum iron, ferritin, soluble transferrin receptor (sTfR) and total iron binding capacity (TIBC) were measured in 298 subjects (70 with NGT, 60 with prediabetes, and 168 with T2DM). Subjects with prediabetes or T2DM showed significantly increased
magnetic hepatic iron concentration (MHIC) (40.59±8.64, 39.27±10.69 vs. 27.81±9.12 μmol/g, P=0.022) and R2* value (47.9±11.85, 47.3±11.49 vs. 34.94±7.01 S-1, P=0.036) in comparison to subjects with NGT. A significantly increased serum iron (26.34±8.28μmol/L), ferritin (128.93±74.58μg/L), TIBC (58.65±6.98μmol/L) were found in prediabetes group compared with NGT group (17.62±7.93 μmol/L, 112.53±84.34 μ g/L and 55.91±10.1 μ mol/L, respectively). A significantly increased ferritin (179.91±140.49 ug/L) and a significantly decreased sTfR (23.67±25.8 nmol/L) could be seen in T2DM group compared to NGT group (112.53±84.34μg/L and 33.78±25.39 nmol/L).Chinese people with prediabetes or T2DM have elevated hepatic iron stores. The increased hepatic iron stores may play an important role in the development of insulin resistance.Supporting source: Chinese National Natural Science Foundation C150201.
Body Composition and Energy Expenditure Changes 3. During a 25-Week Weight Loss Program A.S. Thomas, MS, RD, Target Metabolism, and J.C. Chezem, PhD, RD, Ball State University. The objective of this study was to describe changes in body composition and resting energy expenditure (REE) in adult women enrolled in a 25-week weight loss program. Client records were collected retrospectively from a commercial weight loss program that restricted calories to 90% of measured REE at baseline with adjustment of calories at week 13. Data included total body mass (TBM), fat mass (FM) and fat-free mass (FFM) from air displacement plethysmography, measured REE from indirect calorimetry and predicted REE from linear regression.Data from 69 client records were analyzed. From baseline to week 25, there were significant declines in TBM (95.0 ± 24.1 kg to 87.2 ± 22.9 kg; p=0.000) and FM (47.5 ± 18.5 kg to 39.9 ± 17.6 kg; p=0.000). During the same time period, FFM remained unchanged (47.5 ± 7.3 kg to 47.2 ± 7.0 kg; p≥0.05). REE was significantly lower at weeks 13 (1576.3 ± 313.6 kcal) and 25 (1579.4 ± 335.7 kcal) compared to baseline (1701.1 ± 351.7 kcal) (p=0.000); however, REE at weeks 13 and 25 were similar (p ≥0.05). At weeks 13 and 25, predicted REE (1671.3 ± 254.7 and 1658.5 ± 252.4 kcal, respectively) was significantly higher than measured REE (1576.3 ± 313.6 and 1579.4 ± 335.7 kcal, respectively) (p=0.000). The results of this study suggest that significant weight loss is possible without the loss of FFM and that metabolic adaptation may occur during weight loss.
Palm Diacylglycerol Oil Decreases LDL-C versus 4. Palm Oil: A Pilot Study A.M. Hill1, P.L. Bordi2, 3, J.A. Fleming1 and P.M. Kris-Etherton1 Depts. of Nutritional Sciences1, Hospitality Management2, Center for Food Innovation3, Pennsylvania State University, University Park, PA It is possible to decrease triacylglycerols (TAG) and increase diacylglycerols (DAG) in plant oils. Palm DAG oil may be an alternative to solid fats that contain trans fatty acids and more glyceride-saturated fatty acids (SFA).
Poster viewing hours are Friday night, February 25 and all day on Saturday, February 26. There will be two poster receptions in the Embarcadero room, one on Friday from 6:05-7:30 p.m. and one on Saturday, 5:15-6:45 p.m.
The following abstracts will be presented as posters at the conference. The assigned abstract number will match the number displayed with the poster.
P O S T E R A B S T R A C T S
1 3
Consequently, palm DAG oil would be expected to be less hypercholesterolemic than palm oil. The objective of this study was to compare the effects of a heart healthy diet incorporating palm DAG oil or palm (TAG) oil on lipids and lipoproteins. This pilot study implemented a randomized, 2 period, blinded cross-over controlled feeding design. Individuals with elevated LDL-C (120- 175 mg/dL), consumed a diet that provided: total fat ~28% total energy; SFA ~8.5% total energy that included either palm DAG oil (DAG diet) or palm oil (control, CON diet) for 4 weeks each. Fasting blood samples and weight were taken at the beginning of the study and at the end of each diet period. The DAG diet significantly lowered TC (-10%) and LDL-C (-12%), and also high-density lipoprotein cholesterol (HDL-C, -12%) from baseline (p<0.001). The CON diet elicited smaller reductions in TC (-6%), LDL-C (-6%), and HDL-C (-8%) (p<0.06). Triglycerides were increased by 5% and 13% on the CON and DAG diets, respectively (NS). There was a trend toward a significant difference in LDL-C between the two experimental diets (p=0.09). Our results suggest that Palm DAG oils may be a suitable alternative to palm oil, and other cholesterolraising solid fats. This study was supported by ABUNDA Nutrition.
Holiday Weight Change in a Commercial 5. Weight Loss Program AN Fabricatore, BP Daggy, Y Xiang, Nutrisystem, Inc. Weight gain during the “holiday season,” (i.e., from Thanksgiving to New Year’s Day) is well documented. Overweight/obese persons in the general population are at greatest risk for weight gain during this period, but weight change results among those actively trying to lose weight during the holiday season have not been published. In the present study, we examined weight change during the holiday season among persons enrolled in a commercial weight loss program that includes home delivery of portioncontrolled entrees and snacks that are supplemented with fresh grocery items (i.e., Nutrisystem®). In the years 2006-2009, active Nutrisystem customers who used the company’s web tool to track their weight in the week before Thanksgiving and in the week following New Year’s Day were selected. The sample included 10,215 participants (74% female) with a mean age of 46.3 + (standard deviation) 11.7 years, weight of 91.6 + 21.6 kg, and body mass index of 32.2 + 6.6 kg/m2 at the start of the observation period. Reported weight change was -2.5 + 3.2 kg during the holiday season (mean duration = 44.9 days), equivalent to a -2.7 + 3.3% change in initial weight (median = 2.9%). Average weight changes reported during periods of equal length, but beginning 9, 6, and 3 months before Thanksgiving were -4.5 + 2.8%, -4.1 + 2.8%, and -4.4 + 2.8% of initial weight, respectively. These findings suggest that meaningful weight loss is not only possible, but also common, among persons attempting to lose weight during the holiday season. This work was funded by Nutrisystem, Inc., which employs all authors.
Vitamin D Nutritional Policy Needs a Worldwide Vision 6. for the Future A. W. Norman1,2, H. L. Henry1 and R. Bouillon3 Dept of Biochemistry1 & Biomedical Sciences2, Univ.. California, Riverside, CA, Dept. Experimental Medicine, Katholieke University of Leuven, Leuven, BE
This abstract summarizes the recent dramatic increase in understanding of the many biological actions of vitamin D which make it essential, from a responsible medicine perspective, to reconsider present vitamin D nutritional guidelines and to formulate new world-wide policy changes that will maximize vitamin D’s contributions to improve life-long good health at minimal cost. In spite of many government and medical associations world-wide guidelines for the reference daily intake (RDI) of vitamin D, scientists and nutritionists from many countries agree that at present about half of elderly North Americans and Western Europeans and probably also two-thirds of the rest of the world are not receiving enough vitamin D to maintain healthy bone. Consequently, evidence has accumulated that beside intestine and bone, there are five additional physiological systems where the VDR with 1α,25(OH)2D generates biological responses; these include the immune system (both the innate and adaptive), pancreas and metabolic homeostasis, heart-cardiovascular, muscle and brain systems as well as the control of the cell cycle and thus of the disease process of cancer. Responsible medicine demands that world-wide vitamin D nutritional guidelines reflect current scientific knowledge about vitamin D’s spectrum of activities. Thus world-wide vitamin D nutritional policy is now at a crossroads.
Effect of Ground Cinnamon on Postprandial Blood 7. Glucose Levels in Normal Weight and Obese Subjects A.M. Magistrelli, MS, RD, LDN, Sodexo and J.C. Chezem, PhD, RD, Ball State University The objective of this study was to describe changes in postprandial blood glucose levels following oral administration of 6 g of ground cinnamon in normal weight and obese subjects. In a crossover design, 30 healthy subjects (6 men and 24 women), 15 with BMIs between 20.0 and 24.9 and 15 with BMIs of 30.0 or greater, on two separate occasions consumed 50 grams of available carbohydrate in the form of cooked farina cereal with and without 6 g of ground cinnamon. Blood glucose levels were assessed at minutes 0, 15, 30, 45, 60, 90 and 120. There were no significant differences in blood glucose levels between the two BMI groups at any time point. However, in an analysis of all subjects, the addition of cinnamon to the cereal significantly reduced the incremental area under the curve (IAUC) (p=.008) and blood glucose levels at 15 (p=.001), 30 (p<.001), 45 (p<.001) and 60 (p=.001) minutes. At 120 minutes, blood glucose levels were significantly higher with the addition of cinnamon (p <.001). In both normal weight and obese subjects, ingestion of 6 g of ground cinnamon with farina cereal lowered blood glucose response. These results suggest cinnamon may be effective in moderating postprandial blood glucose response.
Serum Acyl-carnitines and Body Mass Index 8. Nygård O, Strand E, Pedersen ER, Burri L, Bjørndal B, Bohov P, Svardal A, Berge RK. Institute of Medicine, University of Bergen, Bergen, Norway Carnitine is an essential metabolite for the transport and metabolism of fatty acids (FAs) into mitochondria. Partially metabolized short- and medium-chain acyl-carnitine intermediates can be exported out of the mitochondria and tissues for use in other tissues or for urinary excretion. To evaluate the relation between serum fatty acid (FA) profile, selected serum acylcarnitines, and BMI in patients
1 4
referred for stable angina. Serum samples were collected from 1367 patients before coronary angiography between 2000 and 2004 and stored at -80˚C until analysis. FA profile was determined using gas chromatography, while carnitine esters were measured using liquid chromatography/tandem mass spectrometry. Mean ± SD age of the participants was 61 ± 11 years and 75% were male. Partial correlations adjusted for age and sex revealed moderately strong relations between BMI and the concentration of odd carbon-chain acylcarnitines propionylcarnitine (rho=0.21, p<0.001) and valeryl/isovalerylcarnitine (rho=0.25, p<0.001). Furthermore, the odd carbon-chain acylcarnitines and BMI showed moderately strong relations to several even carbon-chain saturated FAs and mono-unsaturated FAs. Typically, associations were positive to FAs of chain-lengths up to 16 or 18C and negative to those above 20C. Based on their association to BMI, the pathophysiological mechanisms of odd carbon-chain acylcarnitines in obesity-related diseases should be elucidated. Funding Source(s): Western Norway Regional Health Authority and University of Bergen.
Dose-related effects of pistachios on plasma sterol 9. levels in moderately hypercholesterolemic individuals Holligan S1, Gebauer SK2, West SG3, Kay CD4, Kris-Etherton PM1 Department of Nutritional Sciences, 3Department of Biobehavioral Health, The Pennsylvania State University, University Park, PA. 2Beltsville Human Nutrition Research Center, Agricultural Research Service, USDA, Beltsville, MD, 4School of Medicine, University of East Anglia, Norwich, UK. Pistachios are a source of plant sterols, which compete with cholesterol for absorption; increased sterol absorption lowers cholesterol synthesis. We conducted a controlled feeding study to determine the dose-related effects of pistachios on plasma sterol levels in individuals (N=28) with moderately elevated LDL-C levels (≥ 2.86 mmol/L). Three diets (2100 kcal/d; SFA ≈ 8%; cholesterol < 300 mg/dl) studied were: Step I diet (CON; 25% total fat); a low-dose pistachio diet (1 PD) with 32-63 g/d pistachios (CON + 10% energy from pistachios, 30% total fat); or a high-dose pistachio diet (2 PD) with 63-126 g/d pistachios (CON + 20% energy from pistachios, 34% total fat). Plasma levels of desmosterol, lathosterol, beta-sitosterol, and campesterol were assayed. We report increases in beta-sitosterol levels in the 2PD versus the 1PD (P < 0.05), in the 2PD versus the CON (P < 0.001), and in the 1PD versus the CON (P < 0.001). Campesterol levels in the CON were higher than the 1PD (P < 0.05) and 2PD (P < 0.05) with no difference between 1PD and 2PD. Since pistachios provide 200 mg of beta-sitosterol versus 10 mg of campesterol in 100 g, inclusion of pistachios may result in increased beta-sitosterol absorption over campesterol. There were no effects of diet on desmosterol or lathosterol levels. We previously found that the 1 PD and 2 PD decreased LDL-C levels by 9% and 12% respectively. Increased sterol absorption from the pistachio diets may reduce dietary cholesterol absorption, providing a mechanism for reducing plasma cholesterol levels. Funding provided by The Western Pistachio Association and the General Clinical Research Center of The Pennsylvania State University (NIH grant M01RR10732).
Vitamin D Supplementation and mortality in patients 10. with end-stage renal disease Jutta Dierkes, S.Kropf, P.Machlitt, U.Domrose, K.H.Neumann, C.Luley, J.Heinz Institute of Medicine, University of Bergen,
Norway; Inst. of Clinical Chemistry, Institute of Biometry and Medical Informatics, Department of Nephrology, University Hospital Magdeburg, Germany; Institute of Agricultural and Nutritional Science, University Halle, Germany Patients with end stage renal disease have an increased risk for mortality. One reason could be that vitamin D deficiency is common in this group of patients. It is unknown whether vitamin D supplementation can reduce mortality. We investigated in an observational, prospective, multi-centre study whether vitamin D supplementation can reduce mortality in 650 patients with end stage renal disease. Median follow up was 2.1 years. At baseline, 67% of the patients received various forms of vitamin D supplements (cholecalciferol, calcitriol, analogs of vitamin D). Patients receiving vitamin D had a reduced risk of mortality (hazard ratio 0.74, 95% confidence interval 0.55-0.99). Analysis for the different forms of vitamin D showed that only patients treated with cholecalciferol had a reduced risk of mortality (HR 0.62, 95% CI 0.41-0.93) We showed in an observational study that patients with end stage renal disease who received vitamin D had a reduced mortality risk. Randomized clinical trials
Supplement use During Pregnancy: Results from the 11. “National Health and Nutritional Examination” Survey Barbara J. Singer, MSPH, MSW, University of Maryland School of Public Health and Amy Branum, MSPH National Center for Health Statistics. Our main objective was to describe the prevalence of vitamin and mineral supplement utilization in a sample of pregnant women, and the correlates associated with increased usage in this population. We conducted a secondary analysis of cross-sectional data across six years (1999 to 2006) of the National Health and Nutritional Examination Survey. Of pregnant women, 78 (SE 2.1) % reported supplement use during their pregnancies. Compared to those not taking supplements, pregnant supplement taking women were more likely to be 30 years of age or older (41.3% SE 2.5, p<O.OOOl), educated with some college or more (66.2% SE 2.8, p<O.OOOl), non-Hispanic White (62.8% SE 2.8, p<O.OOOl), married (66.7% SE 3.1, p<O.OOOl), insured (90.9% SE 1.3) or in their second (41.0% SE 3.7, p<O.Ol) or third (39.7% SE 3.4, p<O.Ol) trimesters. In regression analysis, after adjusting for all other characteristics, women with at least some college education remained more than three times as likely to use supplements during their pregnancy as compared to those with less than a high school education (AOR = 3.3, 95% CI 1.6, 6.8). Multigravida women were less likely to use supplements than primigravida women (AOR = 0.4, 95% CI 0.2, 0.9). Additionally, women in their third trimester of pregnancy were more than four times more likely than those in their first trimester to use supplements (AOR = 4.2, 95% C11.7, 10.7). These findings add to the relatively few studies describing the extent of vitamin or mineral supplement use by women in the USA.
The Cardiovascular Parameters of the Diets of African-12. Americans in South Dallas Churches Carson JAS, Michalsky LO, Latson BR Gimpel N, DeHaven MJ. Departments of Clinical Nutrition and Family Medicine, University of Texas Southwestern Medical Center and University of North Texas Health Science Center
1 5
This study examined whether the dietary intake of members of black churches in South Dallas met National Heart, Lung and Blood Institute (NHLBI) recommendations for Therapeutic Lifestyle Changes. Dietary History Questionnaires were distributed to 392 participants in a health fair style measurement event for the GoodNEWS (Genes, Nutrition, Exercise, Wellness and Spirtual Growth) project in September, 2008. Final analyses were completed on 298 women and 83 men. Mean age was 49 ± 12 years. Mean body mass index (BMI) was 34.1±8.3 with 66.9% classified as obese. Median nutritional daily intakes were 1650 kcal; 33.6% of energy from total fat; 10.3% of energy from saturated fat; 178 gm cholesterol; 17.4 g dietary fiber; 2541 mg sodium. When compared with NHLBI recommendations over half the subjects consumed total fat and cholesterol within an appropriate range, but exceeded saturated fat and sodium recommendations. Dietary fiber intake was below the recommended 20 to 30 gld . A focus on sources of dietary fat and sodium should be paramount in lifestyle measures to reduce cardiovascular risk in this population. Supported by NHLBI Grant ROIHL087768.
The Relationship between Dietary Quality and 13. Inflammatory Markers in Metabolic Syndrome Patients Cheongmin Sohn, Misung Kim, Yesong Lee, Woori Na Major in Food and Nutrition, Wonkwang University, Iksan, Jeonbuk 570-749, Korea Elevated serum concentration of inflammation markers is known as an independent risk factor of metabolic syndrome (MS) and dietary intake is an important factor to control MS. The purpose of this study was to investigated the hypothesis that inflammatory indices are associated with the diet quality index-internatioinal(DQI-I) in subjects with metabolic syndrome. A cross-sectional study was conducted on 156 men and 73 postmenopausal women with metabolic syndrome, defined by three or more risk factors of the modified Adult Treatment Panel III criteria. Serum levels of high sensitive C-reactive protein (hs-CRP), interleukin-6 (IL-6), adiponectin were examined and DQII was assessed using a semi-quantitative food frequency questionnaire. The total DQI-I score was significantly higher in female subjects(65.87±9.86) than in male subjects(62.60±8.95). There was a negative association between hs-CRP and moderation scores for cholesterol (p<0.05). Adiponectin levels were positively correlated with total moderation scores as well as individual scores such as cholesterol and empty calorie food score (p<0.05). Correlation analysis showed positive association between IL-6 and overall balance scores for fatty acid ratio (p<0.05). Therefore, our results provide some evidence that diets quality is associated with inflammation markers and dietary modification might be a predictor to decrease the risk for the metabolic syndrome. This work was supported in part by a grant from National Research Foundation of Korea.
Estimating Nutritional Requirements in the 14. Critically III Obese Christy M. Lawson, MD, University of Tennessee Medical Center, Knoxville; Brian J. Daley, MD, FACS, University of Tennessee Medical Center, Knoxville; Leah K. Schumacher. MS, RD, LDN, CNSC, University of Tennessee Medical Center, Knoxville; Scott Elder, RRT, RPFT, University of Tennessee Medical Center, Knoxville.
Background: Obesity now affects 72.9% of the population of the United States. Obesity greatly impacts the care of patients in the setting of critical illness. There has been a significant amount of controversy in the literature over how to best provide nutritional support to the obese patient, with emerging data to support the practice of underfeeding. Methods: IRB approval was obtained. A retrospective review was performed on all patients with a body mass index (BMI) of greater than 30 who received nutritional support and energy expenditure estimations by indirect calorimetry. We collected data regarding estimated resting energy expenditure, estimated kcal of nutritional support provided, BMI, and thirty day mortality. Results: The average BMI in this study population was 47.6. Patients received an average of 2177 kcal per 24 hours using indirect calorimetry to estimate their resting energy expenditure. Provision of 8 kcallkg of nutritional support would not significantly differ from requirements estimated by the use of indirect calorimetry in this population. Conclusion: The use of8 kcallkg as an estimation of nutritional needs closely approximates resting energy expenditure as predicted by indirect calorimetry in the obese patient. Using this simple equation to estimate energy requirements in patients with a BMI of 30 or greater may help guide nutritional support teams without access to indirect calorimetry in the care of this patient population.
The Limiting Effects of Habitual Exercise on Serum 15. Lipid Profiles Nellie M. Cyr. Ph.D. The University of Maine The purpose of this research was to determine the effects of habitual exercise on serum lipid profiles. As part of the pre-participant screening protocol for inclusion into a multidimensional employee based health promotion program, subjects were asked the following question, “Have you engaged in a comprehensive fitness program 3-5 times per week at an intensity level of 60-80% of your age-adjusted maximal heart rate for a minimum duration of 20 minutes for a minimum of one year”, Based upon their answer to this question, subjects were stratified into one of two groups. Those who answered the question affirmatively were assigned to group one (l-habit-ex; N~50), and those who answered the question, “no” were assigned to group two (2-non-ex; N~65). Four variables were assessed (mg/dl) including total serum cholesterol (TC), high density lipoproteins (HDL-C), low density lipoproteins (LDL-C), and the ratio ofTC:HDL. Results. The results of the data analysis (independent Hest) indicate a significant ditTerence (p<O.05) between the two groups in LDL-C, and non-significant differenCes in TC, HDL-C and TC:HDL. The data is presented according to group classification (group I, then group 2). TC (196.00±36.23 v. 206.50±39.76; p~O.070), HDL-C (51.62±15.05 v. 49.73±13.22; p~O.237, LDL-C (I I 7.55±33.59 v. 131.45±35.09; p~0.020), and the ratio of TC:HDL (4.15±1.55 v. 4.48±1.48;p~0.124). The results of this investigation suggest that habitual exercise may improve select serum lipid values, but in order to positively influence serum lipid profiles, nutrition intervention may be necessary.
Lactose Intolerance and Methanogenic Flora in 16. Ulcerative Colitis Patients SV Rana, KK Prasad, RP Ola, J Kaur, SK Sinha, DK Bhasin, K Singh Department of Gastroenterology, PGIMER, Chandigarh-160012
1 6
Ulcerative colitis (UC) is a chronic inflammatory condition that is related to the gastrointestinal tract with an unknown aetiology. The role of lactose malabsorption in ulcerative colitis is controversial. Higher percentage of lactose intolerance has been reported in UC patients measuring only hydrogen concentration, which may be higher if methane is measured along with hydrogen. Therefore, this study was planned to find out the incidence of lactose intolerance by measuring methane and hydrogen in UC patients. This study was conducted prospectively and included 30 patients with UC and 30 age and gender matched apparently healthy controls. Each subject underwent a breath test using 25g lactose after an overnight fast. An SC Microlyser from Quintron, USA, was used to measure methane and hydrogen at baseline and at every 30 min for 4 h. Lactose intolerance was defined as rise >20ppm over baseline value of hydrogen/methane or both in two consecutive readings within 4 hours. UC and control groups included 69.9% and 66.6% men, respectively. Mean age in two groups was 45.5 ± 20.6 years (range 25–68 years) and 46.6 ± 22.5 years (range 24–68 years), respectively. Incidence of lactose intolerance in UC patients was 63.3% (19/30) while in controls 40% (12/30). The difference was significant (P<0.05). Methanogenic flora was present in 26.7% (8/30) controls and only in 3.3% (1/30) patients of UC. This study indicates that lactose intolerance was significantly higher in Ulcerative Colitis patients while methanogenic flora significantly less as compared to apparently healthy controls. Supporting source for this work was the Institute.
The Effect of Obesity & Weight Loss on TNF alpha & 17. hs CRP in a Group of Morbidly Obese Egyptian Patients Randa Reda Mabrouk, Abeer Shehab, Rania Abou Shady, Lamia Abd el Kader, Immunology Unit , Clinical Pathology Department , Faculty of Medicine, Ain Shams University It has been suggested that the dysregulated secretion of adipokines in obesity can contribute to pathogenesis of obesity-related health problems, and that weight loss affects the immune system by reducing the proinflammatory cytokines in the peripheral blood. The study aimed to evaluate the effect of obesity & weight loss after gastric bypass on serum TNF-alpha and hs CRP, as indicators of inflammation. Morbidly obese group I (n=20) was assessed for the parameters before & after significant weight loss, after gastric bypass operation. Group II (n= 20) comprised the normal weight controls. Quantitative assays of serum TNF-alpha and hs-CRP, using commercially supplied ELISA were performed for all individuals. Serum cholesterol, SGPT and fasting blood sugar were assessed for all individuals. Results: TNF-alpha , hs-CRP, serum cholesterol, & SGPT were significantly higher in the obese group before the operation than after the significant weight loss & than in the normal weight control group. There were also significant positive correlations between TNF-alpha and each of hs-CRP, BMI, serum cholesterol and SGPT among obese individuals. High serum levels of TNF-alpha and hs CRP are associated with obesity and lowering body weight induced fall of these proinflammatory mediators. Additionally, the correlation between serum TNF-alpha and serum SGPT and total cholesterol suggests that the dysregulated adipokine secretion might contribute to obesity –related health problems. Therefore, beside trials to achieve sustainable weight loss, drugs that act to normalize adipocyte functions might be useful. Research was self
funded by the participants. Work was performed in the immunology Unit, Clinical Pathology Department , Ain Shams University, Cairo, Egypt.
Serum Visfatin in a Group of Egyptian Obese Individuals 18. Randa Reda, Abeer Shehab, Dina Soliman , Amira Gabr Immunology Unit , Clincal Pathology Department , Faculty of Medicine, Ain Shams University Adipose tissue is an endocrine organ that secretes many adipokines. visfatin is a relatively novel adipocytokine predominantly secreted from adipocytes and shows insulin mimetic properties . To assess visfatin levels as well as its relation to selected anthropometric and biochemical parameters in adult obesity. The study was conducted on 46 adult obese subjects with body mass index of 52.9 ± 6 kg/m2. The control group included 44 healthy individualswith matched age and sex and with BMI values of 23.1±1 kg/m2. Anthropometric measures included also the height, weight, waist and hip circumferences and waist-to-hip ratio. Serum visfatin and fasting insulin were assessed using commercially supplied ELISA. The insulin resistance index was estimated using the homeostasis model assessment (HOMA). Other biochemical parameters assessed included fasting blood sugar, and total lipid profile. Significant higher serum visfatin levels were found in obese subjects compared to controls. In addition, statistically significant positive correlations between serum visfatin and BMI, waist circumference, hip circumference as well as HOMA in obese subjects were obtained. In the control group, no significant correlation was found between visfatin levels and any anhropometric or biochemical parameter. The observed visfatin increase in obesity together with its positive correlation to HOMA might be suggestive of a role of visfatin in glucose homeostasis. Research was self funded by the participants. Work was perfomed in the Immunology Unit, Clincal Pathology Department , Ain Shams University, Cairo, Egypt.
Effect of Mineral Fortification on Plasma Biochemical 19. Profile in Rates Saeed Akhtar1 and Faqir M. Anjum2, 1 Department of Food Science, Bahauaddin Zakariya University, Multan, Pakistan 2National Institute of Food Science and Technology, University of Agriculture, Faisalabad, Pakistan. This study aimed at investigating the changes in biochemical profile of male rats following eight weeks administration of different concentrations of elemental iron (EI), sodium iron ethylenediaminetetraacetate (NaFeEDTA), zinc sulfate (ZnSO4) and zinc oxide (ZnO) in whole wheat flour (WWF). Eight groups comprising five rats each were fed fortified whole wheat flour in the form of baked pallets while one group served as control. Concentration of total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), triglycerides (TG), total proteins (TP), albumin, globulin, plasma glucose and blood urea nitrogen (BUN) were assayed.. Supplementing mineral fortified diet to male rats did not indicate any significant (p ≤ 0.05) effect on TC concentration; however, diets containing NaFeEDTA alone increased HDL-C to 7.11 percent. NaFeEDTA and ZnSO4 significantly decreased plasma HDL-C concentration to 16.24 percent in male rats. Plasma TG content of male rats remained unchanged on feeding fortified diets. Diets with iron sources exerted little effect on TP concentration
1 7
in the plasma of rats; however these iron sources were shown to induce a change in the presence of zinc sources. Diets containing NaFeEDTA and ZnO together exhibited an increase in plasma glucose as compared to the diets containing NaFeEDTA and ZnO independently. Similarly, a significant increase in BUN was observed when rats were fed diet containing NaFeEDTA with ZnO.
Evidence of Malnutrition in Older Adults Living 20. in Care Homes Authors: Emily S A Norris, Faye Shelton and Marion M Hetherington, Institute of Psychological Sciences, Faculty of Medicine and Health, The University of Leeds, LS2 9JT, England, UK. Risk and prevalence of malnutrition increase with old age and if untreated can exacerbate disease, delay recovery time and increase length of hospital stays. Recent evidence in the UK suggests that ~40% of older adults in care homes are at risk of malnutrition. The present study assessed risk of malnutrition in older adults residing in care homes around West Yorkshire, England with specific focus on whether risk of malnutrition is linked with specific ongoing illnesses. Five hundred and nine residents (375 residential care and 134 nursing care residents) from 25 care homes participated in the study. Participants’ BMI, unplanned weight loss and acute disease score were recorded, and overall risk of malnutrition calculated using the Malnutrition Universal Screening Tool (MUST). Overall risk of malnutrition (medium or high) in care home residents was estimated at 41.6%. As expected the risk of malnutrition was significantly (p < 0.001) greater in nursing care (50%) compared to residential care (33.2%). Risk of malnutrition was also found to be specifically high in those diagnosed with Dementia/Alzheimer’s Disease (42.6%), coronary vascular disease (34.9%) and diabetes (29.7%). Malnutrition risk remains high in vulnerable older adults and may go unnoticed. Efforts to improve nutritional intakes can be implemented effectively where appropriate, with particular attention needed for those living in nursing care or suffering from illnesses that may affect nutritional intakes. Acknowledgements: Co-sponsors for research funding: Wellcome Trust; and Nutricia Advanced Medical Nutrition, Danone Research, Centre for Specialised Nutrition.
B Vitamins in Cancer Patients are Frequently Abnormal, 21. Stimulate and Inhibit Prostate Cancer and Modulate Chemotherapy Toxicity. Glenn Tisman, MD, and April Garcia, Whittier, CA Deficiencies in B vitamins mimic chemotherapy toxicity and stimulate tumors. B vitamins affect genetic expression through SAM generation and epimethylation of DNA and histones Objective: We measured B vitamins in cancer patients. 131 untreated patients had folate, total B12, holotranscobalamin (HoloTC), homocysteine, riboflavin, vitamin B6, and 25-hydroxyvitamin D (25(OH)D) concentrations measured in serum. Of 131 patients, 69% were deficient in HoloTC (< 70 pg/mL). 61% had high homocysteine (> 10 μmol/L). 51% low 25(OH)D (< 80 nmol/L). 30% were B6 deficient. B6 (< 3.3 ng/mL). 21% were deficient in total serum vitamin B12 (< 300 pg/mL). 34% had very high levels of folate (>24 ng/mL) and 5% were deficient in folate (< 5 ng/mL). 7% were deficient in riboflavin (< 6.2 nmol/L). Changes in B12 and folic acid administration modulated serum PSA levels in 2 patients. Life threatening 5FU toxicity was noted in a third
patient with colorectal cancer, high folate with normal dihydropyrimidine dehydrogenase. B vitamin deficiency is common in patients. Varying strata of serum folate levels increased toxicity in some patients when administered fluoropyrimidines. Variations in vitamin concentrations may modulate both efficacy and toxicity of some cancer chemotherapy medications and or directly stimulate tumor cells. Funded by GT.
Evidence for a Vitamin D Deficiency Syndrome: Optimal 22. Serum 25(OH) Vitamin D Concentrations for Chronic Disease and Cancer Prevention Gorham, ED PhD, Garland, CF DrPH, Mohr, SB MPH, Burgi, AA, MPH. Naval Health Research Center, San Diego, CA; Dept of Family and Preventive Medicine, University of California San Diego, La Jolla, CA This study’s objective was to provide evidence for a Vitamin D Deficiency Syndrome (VDDS) and a quantitative basis for estimating optimal serum 25-hydroxyvitamin D levels of 40-60 ng/mL for prevention of the syndrome. Low vitamin D intake or low 25(OH)D serum levels are associated with higher incidence rates of several cancers and increased incidence or mortality from multiple sclerosis, coronary heart disease, and Type 1 diabetes (VDDS), yet the US adult population median is 24 ng/mL, with 72% below 32ng/mL (clinically insufficient) (1,2). The NAS-IOM recently tripled the recommended vitamin D intake at ages 12-79 years, and raised the Upper Level to 4,000 IU/day, with a No Adverse Effect Level of 10,000 IU/day at ages ≥ 19 years (3). This major increase in vitamin D intake provides expanded opportunities for prevention of many chronic diseases comprising the Vitamin D Deficiency Syndrome.
Mediterranean Diet Adherence: A Protective 23. Factor for NAFLD Guglielmo M. Trovato, Daniela Catalano, G. Fabio Martines, Clara Pirri, Francesca M. Trovato and Alessia Pennisi. School of Medicine - Department of Internal Medicine –Clinical Internal Medicine and Therapeutics – State University of Catania, Italy The aim is to investigate relationship of Adherence to Mediterranean Diet Score (AMDS) and NAFLD (Non-Alcoholic-Fatty-Liver-Disease), a condition secondary to unhealthy dietary behavior, reduced physical activity and genetic factors. Mediterranean Diet Profile assessment is a tool used also as a proxy for suggested guidelines in Italy and USA. Methods: 208 consecutive subjects (139F, 69M, years 46.05±12.70, BMI 30.27±6.1) without evidence of viral, toxic, or autoimmune hepatitis, with no/low alcohol habits (less than 20 ml/day), referred to our Day-Hospital-Clinic for dietary counseling were studied. Insulin Resistance was assessed as HOMA (Homeostasis-Model-Assessment-Insulin-Resistance), and adherence to the Mediterranean diet by a validated Mediterranean Diet Score (AMDS: range: 0-55). Dietary data were collected by monthly food-records recall and diet prescription was made by Dietosystem®. Severity of Fatty Liver was assessed by the Ultrasonography Bright-Liver-Score (BLS). Results: 96 NAFLD e 112 non-NAFLD-control subjects age-, gender- and physical activity (Baecke Questionnaire) comparable, were identified. By AMDS, a lower adherence was observed among NAFLD patients, in comparison with controls; the two groups were different for BMI and HOMA (greater in NAFLD). Inverse correlation is present between BLS and AMDS. A Multiple-Linear-
1 8
Regression model, gender-adjusted due to lower AMDS in women, explains 54.9% of the variance to BLS by HOMA (p: 0.002) and AMDS (p: 0.0001). By Odds Ratio the risk for more severe liver steatosis is increased by greater BMI, CRP (C-Reactive-Protein) and HOMA, and decreased by 50% by greater AMDS. A greater Mediterranean Diet Adherence is associated with lower prevalence and severity of fatty liver.
Different Effects of Expert Nutritional Guidelines 24. Counseling Metabolic Syndrome Guglielmo M. Trovato, Daniela Catalano, G. Fabio Martines, Patrizia Pace, Francesca Torrisi, Clara Pirri, Francesca M. Trovato and Alessia Pennisi. Department of Internal Medicine – U.O.C. Clinical Internal Medicine and Therapeutics – University of Catania, Italy Nutritional counseling can improve patients’ dietary behaviors in Metabolic Syndrome. The effectiveness of different professional counseling is not widely investigated. Mediterranean Diet Profile assessment is a tool used also as a proxy for suggested guidelines in Italy and USA. Methods: The study was performed on 2210 out-patients (F 1043, M 1167, age 58,97±15,66 years, BMI 30,05±6,44 Kg/m2), after the first diagnosis of Metabolic Syndrome. The impact of the disease was explained to each patients and appropriate treatment was prescribed. Dietary data were collected mainly by 7-days food recall records. A complete dietary history and prescription was performed by Dietosystem®; adherence to the Mediterranean diet was assessed by the AMDS (Adherence to Mediterranean Diet Score; range 0-55. Difference between achieved changes after one year were assessed comparing the results of the counseling of Primary M.D.s, Specialist M.D.s (Cardiologists, Endocrinologists and Hepatologists) and dietitians, vs. a group of patients which followed personal dietary guidelines. Results: A more favorable and significant difference was observed for the nutritional behavior change achieved by the counseling groups of subjects vs. the no-counseling group. BMI change: (-2,74±4,67 vs. -1,21±2,57; p< 0.0001); AMDS change: (-9,58±10,50 vs. -4,82±7,91). A better BMI outcome was achieved by the dietitians’ counseling group (-4,17±3,92); a better AMDS change was achieved by the dietitians (-10,67±11,26) and primary care doctors groups (-10,11±10,38). Conclusion: greater Diet Adherence in Metabolic Syndrome and greater weight loss are achieved by the dietitians’ counseling, probably due to better focus and impact of specific interventions.
Dietary Counseling in Diabetes: The Need of More 25. Robust Approach Guglielmo M. Trovato, Daniela Catalano, Patrizia Pace, Francesca Torrisi, Clara Pirri, G. Fabio Martines, Francesca M. Trovato and Alessia Pennisi. Department of Internal Medicine – U.O.C. Clinical Internal Medicine and Therapeutics – University of Catania, Italy Healthy eating patterns reduces risks of diabetes, chronic disease and major coronary events. Such dietary patterns offer health benefits to individuals and contribute to public health. A controversial factor is if the adherence of patients to prescribed diets can be a consequence of the different professionals involved. Mediterranean Diet Profile assessment is a tool used also as a proxy for suggested guidelines in Italy and USA. Methods: The study was performed on 595 type-II Diabetes out-patients (F 276, M 319, age 64,33±14,98 years, BMI 28,10±5,06 Kg/
m2 ). The impact of the disease was explained to patients and appropriate treatment was prescribed. Dietary data were collected mainly by 7-days food recall records. A complete dietary history was performed by Dietosystem® software, and adherence assessed by the AMDS (Adherence to Mediterranean Diet Score; range 0-55) using a specific software. Difference between achieved changes after one year were assessed comparing the results of the counseling of Primary M.D.s, Specialist M.D.s (Diabetologists, Endocrinologists) and dietitians, in each group (paired Student’s t test) and in comparison with patients which followed none or personal dietary guidelines. Results: A significant one-year change was observed only in counseling groups, with a more satisfactory glycemic control. BMI change: form 28,07±4,93 to 26,16±3,89; p< 0.0001 AMDS change: form 29,89±8,45 to 36,00±6,88; p< 0.001 No Significant change in no-counseling group. The need of a consistent professional counseling in Diabetes is confirmed: a greater Mediterranean Diet Adherence in Diabetes is achieved along with a greater BMI decrease and a better glycemic control.
Resting Metabolic Rate (RMR) is Increased 26. Synergistically by Single Bolus Intake of Lycium barbarum Fruit (Goji) Juice When Combined with Indigestible Dietary Fiber and/or Caffeine, but not by Fiber or Caffeine alone Harunobu Amagase1 and Dwight M. Nance2 1FreeLife International, Inc, Phoenix, AZ; 2Susan Samueli Center for Integrative Medicine, School of Medicine, University of California at Irvine, Orange, CA L. barbarum increases RMR and reduces body weight in rodents and central adiposity in humans. To investigate the possible synergistic effect of L. barbarum on RMR with dietary fiber and caffeine, human adult subjects (n=12) randomly consumed a single bolus serving of 1 of 12 dietary samples in a randomized, double-blind, placebo controlled, repeated mesures design. The tested products were: placebo, 3 different doses (1, 5 and 10 g) of indigestible soluble dietary fiber, non-caffeinated L. barbarum fruit juice (GoChi®), caffeinated L. barbarum-containing products (Chi3® and its variation formula, and TAIslim®). The non-L. barbarum-containing caffeinated samples consisted of coffee, green tea or 5-Hour Energy®. RMR was measured by breath oxygen volume immediately before (baseline), 1, 2 and 4 h after sample intake. Sample were randomly tested at weekly intervals following an overnight fast. Consumption of all doses of dietary fiber and non-Lycium barbarum-containing caffeinated beverages did not statistically change RMR from control levels. However, the addition of L. barbarum increased RMR proportionally with the dose of fiber and 5 and 10 g dietary fiber plus L. barbarum significantly increased RMR by 7.2 and 8.4%. A low-dose of non-caffeinated L. barbarum produced a nonsignificant increase in RMR, but all L. barbarum-containing products with caffeine increased RMR by 6.3-11.2%. These results show that L. barbarum synergizes with indigestible dietary fiber and/or caffeine to increase RMR in humans.
Genetic Variants of 27. FrO May Influence the Relation Between BMI and BMD in the Elderly Haruna Yamamoto, Norikazu Tanino, Keisuke Fukuo Department of Food Sciences and Nutrition, Mukogawa Women’s University Ikebiraki-cho, Nishinomi ya, Hyogo, Japan
1 9
Genome-wide association studies single-nucleotide polymorph isms (SNPs) in the FrO (fat-mass and obesity-associated gene) are associated with body mass index (8MI). We examined whether SNPs in FrO influence the association between BMI and bone mineral density (BMD) in the community-dwelling elderly subjects. We genotyped 229 elderly subjects from the Nishinomiya City metropolitan area by TaqMan PCR method for two SNPs, rs9939609, rs 1558902, in FTO. BMD was determined by quantitative heel ultrasound as the speed of sound in the calcaneus. Results: We found significant associations for both SNPs with several obesity-related phenotypes. Elderly subjects with AA genotype had significant greater BMI (p=0.045) but lower BMD (p=0.027). Multiple linear regression analysis showed that a significant negative association was observed between A allele and BMD in the elderly women. In addition, positive relationship between waist circumference and BMD was observed in the elderly women without A allele but not in those with A allele. We suggest that genetic variations at the FrO may influence the relationship between BMI and BMD in the elderly.
Blood Folate is Associated with Asymptomatic or Partially 28. Symptomatic Alzheimer’s Disease in the Nun Study Huifen Wang, Andrew Odegaard, Karen Santa Cruz, Mark F. Derosiers, Myron D. GrossUniversity of Minnesota: HW, AO, KS, MG, University of Kentucky, MD Asymptomatic and partially symptomatic Alzheimer’s disease (APSYMAD) is a series of cognitive states wherein subjects have substantial Alzheimer’s disease (AD) pathology (CERAD B or C), but have normal or only partially impaired cognitive function; all of the subjects are non-demented. These cognitive states arise from the prevention or delay of clinical symptoms. Certain nutritional factors induce neuronal compensatory mechanisms which may prevent or delay declines in cognitive function. This study examined blood levels of folate/antioxidants in relation to APSYMAD. Sixty elderly female subjects from the Nun study, a longitudinal study of aging and AD, had AD on the basis of neuropathology exams. Subjects with the highest blood folate levels had a higher likelyhood of being in the APSYMAD group as compared to the demented (AD) group (OR=1.07, 95%CI=1.00~1.16, p<0.06). Adjustment for Apoe4 status, education years and age at blood draw (OR=1.09, 95%CI=1.00~1.18) or further adjusting for other blood nutrient concentrations (OR=1.10, 95%CI=1.00~1.20) slightly enhanced the association (both p<0.05). Restriction of the population to subjects with near normal cognition on the decline to dementia scale (score=1-3) indicated an elevated association with blood folate (OR=1.12, 95% CI=1.01~1.25, p<0.04). Blood carotenoids were not associated with APSYMAD. Folate status may influence the expression of clinical symptoms of Alzheimer’s disease and aid in the prevention of dementia. Sources of support: University of Minnesota and AARP.
Iron Status and Oral Iron Absorption in Short Bowel 29. Syndrome Patients JE Dutra-de-Oliveira MD; Julio Sérgio Marchini MD. Medical School of Ribeirao Preto, University of Sao Paulo, Brazil. Iron deficiency is a common nutritional problem in our hospital setting. Patients that undergo intestinal resection often develop short bowel syndrome including iron deficiency.The objective of this study was to check and
measure in enteroctemized patients through serum iron levels their intestinal iron absorption from different iron compounds. Thirteen short bowel patients were studied in a randomized, double-bind, cross-over study receiving 120 mg of elemental iron from heptahydrate ferrous (FS) or iron ethylenodiaminetetra-acetic-acetic acid (EDTA). After 8 hours fasting blood samples were collected from each patients. Each one received 120 mg of elemental iron from FS or EDTA and blood samples were again collected, 1 and 2 hours later. Mean iron blood levels for the group that received FS increased 107 % after 1 hour and 123% after 2 hours. In the group receiving iron EDTA, their 1 hour value increased 28% in 1 hour and 40% in 2hours. The increased values for FS were statistically greater than de values of iron. FS and EDTA serum iron, 1 or 2 hours values with the same iron intake increased 75% and 130% with FS and 14% and 30% with iron EDTA in normal patients. It was concluded that oral iron was absorbed in our short bowel patients and there was a higher absorption of ferrous sulfate than from iron EDTA.
A Mediterranean-style Low-glycemic-load Diet improves 30. Parameters of Metabolic Syndrome in Women, and Addition of a Plant Sterol-based Medical Food Enhances Benefits on Lipoprotein Metabolism Jennifer L. Jones, Maria Luz Fernandez and Robert H. Lerman We evaluated lipoprotein profiles of women classified with metabolic syndrome (MetS) and with elevated plasma low-density lipoprotein cholesterol (LDL-C) adhering to a Mediterranean-style low-glycemic-load (LGL) diet alone (n = 44) or accompanied by intake of a medical food containing plant sterols and soy protein (n = 45) for 12 weeks. Fasting blood samples and 3-day dietary records were obtained at baseline, week 8 and week 12 for analysis. Enzymatic methods were used for plasma lipid analysis and nuclear magnetic resonance (NMR) was utilized to assess lipoprotein subfractions and size. The dietary records indicated decreases in energy intake from baseline, paralleled by a decrease in carbohydrate intake in both groups (p < 0.001); however an increase in protein intake was only observed in the treatment arm (p < 0.001). Both groups experienced favorable impacts on MetS parameters, with decreases in plasma triglycerides (TG), blood pressure, and waist circumference (p < 0.01). All subjects had decreases in both atherogenic large VLDL (p < 0.005) and small LDL particles (p < 0.0001). Reductions in plasma LDL, non-high-density lipoprotein cholesterol (non-HDL-C), apolipoprotein B (apo B), and apo B/apo A1 were found in both groups, however, they were greater in the treatment arm (P < 0.05), suggesting that the medical food had a greater effect in altering lipoprotein metabolism. A Mediterranean-style LGL diet effectively reduces the variables of MetS, and addition of the medical food may reduce risk for heart disease due to a less atherogenic lipoprotein profile. Supported by MetaProteomics, LLC, Gig Harbor, WA.
Relationship Between Zinc Status and Insulin Resistance 31. and Glycemic Control in Obese, Korean Women Jihye Kim, Sunju Lee Daegu University, Gyeongbuk, Korea The study was done to determine the effect of zinc supplementation on insulin resistance and glycemic control in obese Korean women. Zinc measures were assessed in 40 obese women (body mass inde≥x25 kg/m 2 or obesity index≥120%) aged 19 -28 years. Twenty obese women
2 0
took 30 mg/day of supplemental zinc as zinc gluconate during 8 weeks and 20 women took placebo. Usual zinc intake was evaluated by 3 day diet records. Oral glucose tolerance test was conducted to observe glycemic control and insulin sensitivity. Insulin resistance was measured by Homeostasis model assessment (HOMA) index. Leptin and adiponectin were measured with radioimmunoassay. Dietary zinc was 7.3mg/day and the concentrations of serum zinc and urinary zinc in obese women were 84.8g/dL and 347μg/day at baseline. Serum zinc and urinary zinc concentrations increased to 97.7 g/dL and 541 μg/day with zinc supplementation, respectively (p<0.05). Serum zinc was positively correlated with waist -hip ratio(r=0.41, p=0.008) in obese women. Fasting glucose and insulin concentrations were 90.6 mg/dL and 13.0μIU/mL at baseline. Fasting glucose and insulin, HOMA, and insulin sensitivity did not change during zinc supplementation. Lipid profiles such as triglyceride, total cholesterol, and HDL-cholesterol and adipokines such as leptin and adiponectin did not differ with supplementation. These results suggest that supplemental zinc may not affect insulin resistance, lipid profiles, and adipocyte hormones in obese Korean women.
Eating Behaviors, Mental Health, Abdominal 32. Obesity in Older Georgian Participating in Congregate Meal Programs Katie N. Porter and Mary Ann Johnson, University of Georgia. This study explored the relationships of abnormal eating behaviors and mental health symptoms with obesity in congregate meal participants in Georgia (n=124, mean age= 75 years, 76% female, 44% African American). Abnormal eating behaviors were evaluated using the Three-Factor Eating Questionnaire (TFEQ, 18 questions); mental health was assessed using the Depression Anxiety Stress Scale (DASS, 21 questions); abdominal obesity was defined by waist circumference measures. Approximately 76% had abdominal obesity; 51% were obese; mean cognitive restraint score was 10.8 (on a scale of 6-24), uncontrolled eating score was 14.2 (9-36) and emotional eating score was 5.2 (3-12); moderate to extremely severe depression, anxiety, and stress were reported in 11%, 14%, and 10%; and 23% were food insecure (did not “always have enough money to buy the food you need”). Abdominal obesity was associated with cognitive restraint (rho= 0.30, p < 0.001), uncontrolled eating (rho= 0.30, p <0.001), emotional eating (rho=0.19, p<0.05), anxiety (rho=0.17, p<0.07). Of the six eating behavior and mental health indices, uncontrolled eating was consistently associated with abdominal obesity (p<0.05) when controlled for potential confounders in a series of regression analyses. Thus, mental health symptoms and abnormal eating behaviors, particularly uncontrolled eating, may be important targets for interdisciplinary healthcare teams in reducing abdominal obesity in congregate meal participants. This research was supported by Northeast Georgia’s Area Agency on Aging.
The Effect of Whey Protein on the Immune 33. Response to the Pneumovax Vaccine: A Randomized Placebo-controlled Clinical Trial Laura K. Fischer, J. Bruce German, M. Eric Gershwin, University of California, Davis The purpose of this study was to evaluate the effects of whey protein on the immune response to vaccine
and to evaluate a marker of immune function, indolamine2,3-diooxygenase (IDO), as a predictor of vaccine responsiveness. Subjects were given a whey or soy supplement for 8 weeks and the immune response to 14 vaccine-specific serotypes was measured after vaccination with Pneumovax. The immune response was evaluated by measuring the change in antibody titer from baseline to peak. IDO activity was evaluated by measuring the concentration of enzyme substrate and product. For serotype 1, the immune response was significantly greater in whey-fed subjects versus soy-fed subjects. There was no significant difference in the immune response for any other serotypes. IDO activity was not significantly correlated with vaccine responsiveness. Individuals over age 50 are at increasing risk of infectious disease morbidity and mortality due to declining immune function, termed immune senescence. It is critical to determine those whose immune systems are non-functional in responding appropriately to vaccinations. For those individuals, therapeutics capable of recovering immune functions are a public health priority. Results from this study testing a previously proposed immune function diagnostic were negative. Using the actual vaccination response as a functional endpoint, dietary intervention had a significant impact on the response to vaccine and highlights the potential significance of diet in restoring immune function. The authors would like to acknowledge the following funding sources: the Grant Number UL1 RR024146 from the National Center for Research Resources (NCRR), a component of the National Institutes of Health (NIH), and NIH Roadmap for Medical Research, Dairy Management Inc., and the National Dairy Council.
34. Dietitian Population Management in Women with a History of Gestational Diabetes L. Daniels, A. Bayer, W. Donahoo. Kaiser Permanente Colorado Up to 50% of women with Gestational Diabetes (GDM) will develop type 2 diabetes (T2DM) within 5-10 years after delivery. We preformed focused outreach effort to encourage lifestyle modifications and to increase screening of post delivery fasting blood sugar testing for women who had GDM. There were 885 Women with a History of GDM identified by registry. 505 women received an outreach letter which included a healthy habits survey, and educational offerings on preventing diabetes. 340 Women had a subsequent intervention with a dietitian after the outreach letter packet. A follow-up questionnaire was sent to all those who initially responded. Results: 124 members (24%of outreached) obtained a fasting blood sugar, a reduction of 4% in members who had never had a post-partum fasting blood sugar. 138 Women completed the pre questionnaire only and 60 Women completed the pre and post questionnaire. There were reported improvements in the number of women trying to lose weight, in the amount of physical activity, and in consumption of vegetables. Through a focused outreach by dietitians, there was an improvement in fasting glucose screening and positive changes in self reported lifestyle activities. Further work is ongoing to determine optimal type of outreach and support in ongoing lifestyle management.
2 1
Pharmacokinetics of Daily versus Monthly Vitamin 35. D3 Supplementation Mike E Meekins, Sara S Oberhelman, Bernard R Lee, Brian M Gardner, Stephen S Cha, Ravinder J Singh, Philip R Fischer, Tom D Thacher, John M Pettifor Mayo Clinic, Rochester, MN The effectiveness of vitamin D supplementation may vary, depending on the dosing regimen. The objective was to compare the temporal trend of vitamin D metabolites and safety of daily dosing of vitamin D and a single, larger dose in healthy, non-pregnant, non-lactating, female subjects ages 18 – 40. Randomized, prospective, open label, clinical trial of oral cholecalciferol supplementation comparing 5,000 international units (IU) daily for 28 days (n = 20) with a single dose of 150,000 IU (n = 19) during March and April in Rochester, MN. Serum calcium, phosphorus, cholecalciferol, and 25-hydroxyvitamin D (25(OH)D) concentrations were measured at baseline and at 1, 3, 7, 14, and 28 days after enrollment. The 5,000 IU daily group had 19 more days of detectable serum cholecalciferol than the 150,000 IU single dose group (21.2 ± 6.0 days vs. 9.6 ± 7.6 days; p <0.01 ). However, there was no difference in serum cholecalciferol area under the curve (AUC28) (p = 0.5) between treatment groups. The 150,000 IU group had a greater 25(OH)D AUC28 than the 5,000 IU group (p < 0.01), however there was no difference in serum 25(OH)D concentration between groups at 28 days (48.9 ± 9.9 ng/mL vs. 55.1 ± 10.2 ng/mL; p = 0.28). There were no clinically relevant changes in serum calcium or phosphorous between treatment groups or from baseline values throughout the study. A single dose of vitamin D as 150,000 IU provided fewer days of detectable cholecalciferol levels than daily supplementation with 5000 IU over 28 days, but the AUC28 values and 25(OH)D concentrations at day 28 were equivalent. Both regimens appeared to be safe. Funding for this project was provided by Mayo Family Medicine small grants and discretionary funds, Mayo Pediatric & Adolescent Medicine departmental funds, Mayo Department of Pharmacy research funds, and NIH/NCRR CTSA Grant No. UL1 RR024150.
A Systematic Review and Meta-analysis of CHD Events: 36. A Look at Prospective Cohort Studies of Dietary Glycemic Index and Load. Mirrahimi A., Jenkins D.J.A., De Souza R., Chiavaroli L., Srichaikul K., Sievenpiper J.L., Kendall C.W.C. Department of Nutritional Sciences, University of Toronto, ON Diabetes and Coronary Heart Disease (CHD) are linked and may share a common dietary etiology. Low Glycemic index (GI) diets have been found useful in diabetes prevention and treatment. We have therefore examined the effects of low GI diets on CHD. We therefore searched MEDLINE, EMBASE, CINAHL, and the Cochrane Libraries for prospective cohorts with CHD/MI/CVD outcomes with respect to dietary Glycemic Index (GI) or Glycemic Load (GL). We used Review Manager to pool Risk Ratios (RR) and Hazard Ratios (HR) under generic inverse variance and random effects models. Results were expressed in RR with 95% CI. Heterogeneity was assessed by χ2 and quantified by I2. A priori subgroup analyses were performed on the basis of sex, study quality, and duration. 143 trials were identified and systematically reviewed: 6 trials met the eligibility criteria. The pooled RR analyses demonstrated a significant elevation in CHD risk related to highest quantiles of dietary GI (RR = 1.15 [1.05, 1.26], P=0.002, I² = 16%, P=0.30). Likewise, the pooled analyses for GL, showed a significantly higher risk
for CHD events in the highest quantiles of dietary GL, (RR = 1.35 [1.10, 1.65], P=0.004, I² = 58%, P=0.03), sources of heterogeneity were explored in subgroup analyses. These results encourage the use of low GI and GL diets in long term clinical studies with strong surrogate markers of CHD and CVD using detailed dietary assessments to further establish the importance of the glycemic index of foods in disease prevention. Canadian Institutes of Health Research.
The Effect of a Low Glycemic Index Diet on LDL 37. Oxidation in Diabetes. Mirrahimi A., Srichaikul K., Nishi S., Bashyam B., Sievenpiper J.L., Kendall C.W.C., Jenkins D.J.A. Department of Nutritional Sciences, University of Toronto, ON. Aim: To assess the effect of a low glycemic index diet on LDL-oxidation. Background: One of the benefits of reduction in postprandial glycemia has been proposed to be the reduction in free radical generation with reduced oxidative damage to DNA, protein, and lipids, including LDL oxidation. We have therefore assessed LDL oxidation in diabetic subjects consuming a low glycemic index diet. Methods: a post-hoc analysis of 152 diabetic subjects who completed a six months trial of either low glycemic index (GI) or high fiber (HiFi) foods in a randomized study. Fasting blood and diet histories were obtained at the start and the end of the study. Results: Despite a significant reduction in HbA1c [−0.50% absolute HbA1c units (95% CI, −0.61% to −0.39%) on the low GI, (P<0.001)] no treatment differences were seen in markers of LDL oxidation (TBARs or conjugated dienes in the LDL fraction). However, after pooling the data from both treatments, carbohydrate from low GI foods related both to the reduction in HbA1c (r=0.22, n=152, P=0.007) and to markers of LDL oxidation (Conjugated dienes, r=0.22, P=0.008 and TBARs, r=0.17, P=0.039). HbA1c also related to markers of LDL oxidation (TBARS, r=0.16, P=0.045 and conjugated dienes, r=0.14, P=0.08) Conclusion: Despite lack of a treatment difference, consumption of low GI foods appears to reduce oxidative damage to LDL possibly related to improved glycemic control. Funding Source(s): Canadian Institutes of Health Research.
Association of Cardiorespiratory Fitness and Adiposity 38. with Metabolic Risk Factors in Apparently Healthy Men in Urban North India Neha Singhal, Anupa Siddhu, Peeyush Jain, Lady Irwin College, University of Delhi, New Delhi-110001, India, Fortis-Escorts Heart Institute and Research Centre, New Delhi-110025, India Although both cardiorespiratory fitness (CRF) and adiposity are significant predictors of metabolic risk, independent contribution of each is not fully known. The present study aimed to determine the relative impact of CRF and adiposity on select metabolic risk factors in apparently healthy Indian men having no history of coronary heart disease (CHD), stroke, myocardial infarction, type 2 diabetes mellitus (T2DM), thyroid or tuberculosis. This cross-sectional study was carried out on 554 apparently healthy urban Indian men (25-64 years). Weight, body mass index (BMI), waist circumference (WC) were used to express levels of adiposity while CRF was expressed in terms of highest metabolic equivalents (METs) achieved on maximal treadmill test using Bruce Protocol. Metabolic risk factors included: fasting blood glucose (FBG), total cholesterol, triglycerides, low-
2 2
density lipoprotein-cholesterol (LDL-c) and high-density lipoprotein-cholesterol (HDL-c). Adiposity (weight, BMI, WC) showed higher correlation to FBG and triglycerides (p <0.05), while CRF was better correlated to HDL-c (p <0.05), after adjusting for age, family history of hypertension, T2DM, CHD/stroke, smoking and alcohol. It was observed that neither measures of adiposity (weight, BMI and WC) nor CRF showed any significant association with total cholesterol and LDL-c after adjusting for confounding variables. Both CRF and adiposity are independently correlated to select metabolic risk factors. Hence, improvement in CRF and reduction in adiposity, through increased physical activity, should together be the targets for reducing the metabolic risk in primary prevention programs among urban north Indian men. Funding Source(s): Indian Council of Medical Research, Ministry of Health and Family Welfare, Government of India, India.
A Study on Interplay Between Genetic And Dietary 39. Factors With Respect To Coronary Artery Disease Prakruti R.Singh, Manjari S. Mukherjee, Smita S. Lele Food Engineering and Technology Department, Institute of Chemical Technology, Matunga, Mumbai Coronary artery disease (CAD) is highly prevalent in Asian Indian population with characteristic features such as early onset, a high occurrence of multiple vessel disease and diffuse lesions. CAD is a complex disorder involving a subtle interplay between genetic and non-genetic factor. Of the various non-genetic influences diet is important. The daily requirement for ‘methyl dietary’ micronutrients such as folate, vitamin B6 and B12 are obtained from diet. Therefore, the aim of the present study was to evaluate simultaneously for the association of five known folate gene polymorphisms with CAD, and document any genotype variations at these loci at low levels of intake of ‘methyl dietary’ micronutrients such as folate, vitamins B6 and B12. 252 CAD patients and 252 controls of Asian Indian origin were typed for two single nucleotide polymorphisms (SNP), two insertion/deletion and one repeat polymorphism and the consumption of micronutrients was estimated from a diet questionnaire. The betaine homocysteine S methyltransferase (BHMT) 742G>A SNP was associated with risk for early onset of CAD (odds ratio with 95% confidence intervals, 1.52; 0.96 to 2.41; p=0.04) but no association was observed for all age of onset. Furthermore, subjects bearing minor allele for BHMT and with micronutrient intake in the lowest quintile there were more patients than controls (50% versus 37%; p=0.042). Therefore, the presence of minor BHMT allele together with low intake of ‘methyldietary’ micronutrients might increase the risk of CAD.
A Virtual Grocery Store As A Simulator For Long Term 40. Behavior Change Rachel Jones, MPH, RD University of Utah A virtual online grocery store created for college students to support concepts taught in a basic nutrition course leads to behavior change. The tool has ten objectives which students ‘try on’ and report back to instructors regarding feedback from consuming nutrient dense foods related to specific micro and macro nutrients. Results from over 18 months of use, reveal that students experience a qualitative diet change based on using the tool to enhance learning. Information translates to lifestyle imprint through the use of repetitive return to objective based experiments with
built in accountability to the instructor and T.A.’s. The virtual grocery store has been used with nearly 2000 students.
Investigation of Frailty and Dietary Patterns of Free-41. Living Elderly Individuals Ribeiro SML, Kehayias JJ, Ordonez TN, Marques TJO, Silva TBL, Yassuda MS, Cachioni M. School of Arts, Sciences and Humanities- University of São Paulo- Brazil; USDA Human Nutrition Research Center on Aging, Tufts University- Boston-MA-USA. We aim to investigate frailty in a community-dwelling elderly group, as well as the association between frailty and dietary patterns. Subjects from an Open University for the Third Age; - inclusion criteria: 60+ years, both genders, minimal literacy; -exclusion: any signal of dementia, serious vision and audition problems. Diet pattern: from a Food Frequency Questionnaire (FFQ) and some specific questions related to food behavior; Cognitive decline: from Mini Mental-Status Exam; Anthropometry: BMI (body mass index, in Kg/m2); Frailty: according to criteria suggested by Fried et al (2004): weight loss, exhaustion, weakness, gait speed and physical activity. Data analysis: - cluster analysis (partition method) to identify the relationship between diet pattern and frailty together; - U-test to compare the clusters; -multivariate logistic regression analysis (stepwise forward). Two clusters were constituted. Cluster 1: - higher intake of all the food groups, except dairy group; -higher intake of onion, beef and pork, milk, white sugar and spices; - more pleasure in cooking and eating. Cluster 2: - higher intake of white rice, butter and artificial sweetener, besides a higher intake of medicines, and higher number of frail and depressive individuals. From multivariate logistic regression, the variables that explained the majority of the inclusions in Cluster 2 were medicine intake and housing arrangement. Affective and social aspects of food behavior, together with the amount of food consumed, seem to explain frailty more than the consumption of specific foods or food groups.
Comparison of Body Compositions of Spinal Cord 42. Injured and Poliomyelitis Active Individuals Ribeiro SML, Kehayias JJ, da Silva RC, Tirapegui J. School of Arts, Sciences and Humanities- University of São Paulo; USDA Human Nutrition Research Center on Aging, Tufts University- Boston MA-USA, Faculty of Pharmaceutical Sciences, University of São Paulo. This work has the aims to evaluate the body composition of active handicapped individuals from DEXA and BIVA analysis, according to the source of the deficiency and according to gender. Males and females, active, freeliving individuals distributed in two groups: a-) low (T5-T12) spinal cord injury (SCI group) and b-) poliomyelitis sequels (P group). Measurements: body mass index (BMI), Total body DEXA analysis (Lunar Corporation; Madison, Wiscosin, USA), Bioelectrical impedance analysis (Biodynamics 350e) analyzed from resistance (R) and reactance (Xo), plotted on an R/H Xc/H graph (BIVA analysis). Statistical Analysis: groups were compared by t-test for independent samples. Statistically significant differences between the mean vectors of the BIVA analysis were assessed with Hotelling’s T2 test and by calculating the distance between the two groups (Mahalanobis distance; D). No differences were observed between SCI and polio regarding BMI or fat mass, both in men and women. The fat-free mass and bone mineral content are lower in polio than SCI, but only in men.
2 3
In both genders, the polio group presented lower Xc/Ht and higher R/Ht than SCI, and consequently lowest phase angle; however the distance between polio and SCI (D value) in women is much lower than the same “D’ value in men. Polio individuals seem to be at higher nutritional risk than SCI, and this risk seems to be higher in men. More investigations are necessary.
43. Response to Pyrroloquinoline Quinone (PQQ) after Oral Supplementation C. Harris, M. Satre, W. Chowanadisai and R. Rucker Nutrition, UC Davis. PQQ improves reproduction, neonatal development, and mitochondrial function in animal and cell models by mechanisms that involve interaction with cell signaling pathways (JBC 285:142-52; J Nutr 136:390-6; Biochem. J 429:515-26). Determine if actions in humans elicited by PQQ may be linked to corresponding mechanistic and functional data from animal and cell culture studies. In a randomized study, 10 subjects ingested PQQ and were examined in two separate trials at daily/weekly intervals. Measurements included plasma antioxidant potential (TBARS and TRAP), measures of inflammation (C-reactive protein), mitochondriogenesis (plasma mtDNA levels) and standard clinical indices (e.g., AspAT, cholesterol, glucose, HDL, LDL, TAGs, etc.). At each dose (0 to 40 mg/day), ~0.1- 0.2 % was excreted in urine with a peak in plasma at 2-3 h after each dose (half-life of 3-5 h). Improvements in plasma were observed even at nM PQQ plasma concentrations. Decreased levels of C-reactive protein (10-400%) were also observed (~ 30 mg PQQ/day X 3 d; P <0.01). Plasma mtDNA levels were elevated following treatment, which was taken as an indirect measure of changes in mitochondrial amount. All other clinical indices were normal. PQQ elicits physiological response at doses that may be achieved with intakes of 30 mg/day or less. Funded in part by Mitsubishi Gas Chemical and the CA Vitamin Settlement Fund.
Efficacy of a Single 250,000IU Dose of Vitamin D3 44. in Subjects with Cystic Fibrosis During Pulmonary Exacerbation. Ruth E. Grossmann, Meena Kumari, Shabnam Seydafkan, Margaret E. Jenkins, Li Hao, Arlene Stecenko, SuSu Zughaier, Thomas Ziegler, and Vin Tangpricha. Emory Cystic Fibrosis Center, Emory University, Atlanta, GA Evaluate serum 25(OH)D and antimicrobial peptide response to vitamin D3. Cystic fibrosis (CF), the most common lethal genetic disorder among Caucasians in the United States, causes respiratory failure secondary to chronic lung infection. Vitamin D is necessary for production of antimicrobial peptides. Most CF subjects are vitamin D deficient and current supplementation strategies are ineffective. We randomized 30 CF subjects admitted for pulmonary exacerbation to a single 250,000IU dose of vitamin D3 or placebo and measured serum 25(OH)D and LL-37, an antimicrobial peptide, at baseline, one week and three months. We found the mean increase in serum 25(OH)D was 27.07ng/ml in the vitamin D group and -0.69ng/ml in the placebo group(p<0.001). At baseline 60% of the vitamin D group was sufficient, 100% one week postintervention and 73.3% remained sufficient at three months. In the placebo group on standard vitamin D supplementation, 46.7% was sufficient at baseline, 46.7% at one week and
33.3% at three months(p=0.56, 0.006 and 0.12 respectively). Although not statistically significant, in the unadjusted data, the vitamin D group increased LL-37 almost three-fold more than the placebo group increase. These results indicate that a single large dose of vitamin D3 is adequate to produce sufficiency in CF subjects during pulmonary exacerbation and maintains vitamin D sufficiency in a greater proportion of CF subjects than current supplementation. The results also indicate that vitamin D therapy may increase the level of antimicrobial peptides present in the serum of CF patients and may improve immune function in CF patients. Funding: The Cystic Fibrosis Foundation, Emory Center for CF Research, The BTR Group, and the NIH.
Effect of Serum Folate Levels on Natural Killer Cells 45. Citotoxic Activity in Healthy Subjects Sandra Hirsch, Dante Miranda, Catalina Fuente*, Laura Leiv, Gladys Barrera, María Pía de la Maza, Margarita Montoya, Ana María Ronco, Daniel Bunout. Institute of Nutrition and Food Technology, University of Chile, Santiago, Chile. °Chemical and Pharmaceutical Sciences School, University of Chile. During last few years, folic acid consumption at high levels has been associated with cancer risk, specially colon, breast and prostate cancer. Several mechanisms have been proposed to explain this association. One of the mechanisms proposed is that serum folate at supra-physiologic levels may decrease natural killer cell (NK) citotoxic activity and its action as anti-tumoral barrier. The aim was to determine the association between serum folate levels and NK citotoxic activity in healthy subject. Methods: 227 healthy males and females aged 20 years or more were recruited; serum lipid profile, serum folate, vitamin B12 levels and NK citotoxic activity were measured. NK cell cytotoxicity was measured using radioactive chrome liberation (Cr51) Mean serum folate level in all the sample was 39.7 ± 12.4 nmol/L (range: 15.1 - 75.6) nmol/L. 24 % of the sample presented serum folate at supra-physiologic levels(≥ 45nmol/L) . NK citotoxic activity was not associated with serum folate levels. There was no association between NK citotoxic activity and other variables such as, age, sex, BMI and serum lipid profile or vitamin B12 levels. In this study, NK citotoxic activity was not mediated by serum folate levels. Grant: Fondecyt Nº 1090166.
Effect of 5-methyltetrahydrofolic Acid (5-MTHF) and 46. Folic Acid in Natural Killer (NK) Cell Function in Vitro 1Miranda D., 2Montoya M., 1Muñoz E., 3Bunout D, 3de la Maza MP 3Barrera G, 3Leiva L, 3Ronco AM, 2Jara C and 3Hirsch S. 1Chemical and Pharmaceutical Sciences Faculty, 2University of Santiago de Chile and 3Institute of Nutrition and Food Technology, University of Chile. Folates play a key role in various metabolic processes. Accumulating evidence suggests that low and high serum folate levels could be associated with the development of cancer. Interestingly, due to the folic acid fortification programs, supraphysiologic serum folate levels can be reached in the population. NK cells, the CD3- CD56+ CD16+ subset of peripheral blood lymphocytes, are involved in non-MHC-restricted natural immunity to malignant target cells. The association of abnormalities in NK cell numbers or functions with cancer has been clearly defined in recent years. The aim was to study in vitro the possible effect of
2 4
different concentration of 5-MTHF or folic acid on NK cell cytotoxic function, expression of the receptors KIRDL4, KIRDL3, NKG2D and synthesis of TNF-α and IFNγ. Methods: Volunteersderived PBMC and highly purified NK cells (95% CD56+ CD16+) were grown in folic acid free-RPMI 1640 supplemented either with folic acid or 5-MTHF (15 -100 nM) during 72-96 h. no differences in the citolytic activity of PBMC and purified NK cells were observed. Under this conditions we did not demonstrate any change in the presence of the membrane receptors as well as the intracellular levels of the cytokines TNF-α and IFNγ. Our date would indicate that high dose of 5-MTHF or folic acid might not be harmful to the NK cell function in vitro. Grant: Fondecyt Nº 1090166.
Optimal PA level and to Assess the Relation 47. Between Physical Activity and Birth Outcomes Among the Same Participants Seifu Hagos1,2, Lieven Huybregts,2,3, and Patrick Kolsteren2,3 1School of Public Health, Addis Ababa University, Addis Ababa, Ethiopia, 2Department of Food Safety and Food Quality, Faculty of Bioscience Engineering, Ghent University, Belgium, 3Nutrition and Child Health Unit, Department of Public Health, Prince Leopold Institute of Tropical Medicine, Antwerp, Belgium The available evidences on physical activity of pregnant woman and their recommendations are not uniform. Some evidences suggest the negative effect of physical activity on birth outcomes such as low birth weight. While others states that physical activity during pregnancy has no significance influence on birth outcomes. Objective - The objectives of the study the optimal PA level and to assess the relation between physical activity and birth outcomes among the same participants. This study used data from several studies performed between 2006-2008, a non-blinded randomized controlled trial (RCT) conducted to asseys the effects of a fortified food supplement against a multiple micronutrient tablet on birth size. A Convenient sample of 119 pregnant women was used [for this study].
Refeeding Syndrome: An Under-diagnosis and Under-48. treated Clinical Nutrition Condition Julio Sérgio Marchini MD, Juliana DC Machado, JE Dutra-de- Oliveira MD.Medical School of Ribeirao Preto, University of Sao Paulo, Brazil. Refeeding syndrome (RFS) has been well described but is also a frequently forgotten and undiagnosed complication in clinical practice, which, if untreated, may lead to death. Patients who are more prone to developing RFS are those with at least one of the following conditions: BMI <16 kg/m², a recent unintentional weight loss >15%, very little nutritional intake for >10 days, and/or low plasma concentrations of potassium, phosphate or magnesium before feeding; and those with at least two of the following conditions: BMI <18.5 kg/m², a recent weight loss >10%,very little nutritional intake for >5 day, and/or a history of alcohol or drug use, including insulin, chemotherapy or diuretics. We reported here a patient who, after undergoing intestinal resection (short gut syndrome), presented diarrhea, weight loss and protein–energy malnutrition. After nutritional assessment, it was decided to feed the patient by parenteral route. After 16h of parenteral nutrition, the patient developed supra ventricular tachycardia, hypomagnesaemia and hypocalcaemia, and RFS was
diagnosed and managed All electrolyte disturbances were corrected and thiamine was supplemented (100 mg per day) before restarting nutritional support. The patient started to receive about 40% of his energy requirements and after 4 days he was able to receive his full energy requirements without any metabolic complication.
Knowledge of College Students About Food- 49. sustainable Practices Setareh Torabian, DrPH1, Yelena Nisnevich, MS1 and Scott Plunkett, PhD2 1Department of Family and Consumer Sciences, School of Health and Human Development, California State University Northridge, Northridge, CA; 2Department of Psychology, California State University Northridge, Northridge, CA Sustainability means living in balance with natural resources, as well as preserving the environment for future generations. This study surveyed CSUN students’ knowledge about food sustainability, determining whether existing knowledge influences students’ food sustainable practices. With a sample of 230 respondents, data was analyzed with chi-square tests, ANOVA, and correlation analysis. The results indicated that, even though overall knowledge about food sustainability is low, half of the population (50.48%) demonstrated some knowledge, and students’ choice of major was significantly related to their knowledge: specifically, nutrition and health majors had significantly higher food sustainability knowledge than other majors. Additionally, this study verified that students’ knowledge was significantly and positively correlated with their attitude about food sustainable practices and suggested that students with more knowledge about food sustainability are more likely to substitute meat with more sustainable vegetarian products, to buy organic foods, and to pay more for sustainable food products.
Effect Of Daily Intake of Prebiotic (Fructooligosaccharide) 50. On Weight Gain And Reduction Of Acute Diarrhea Among Children in a Bangladesh Urban Slum: A Randomized Double-masked Placebo-controlled Study Shafiqul Alam Sarker,1 Sadako Nakamura,2 Mohammad Abdul Wahed, 1 Yukiko Wagatsuma, 2 Tsuneyuki Oku2 and Kazuhiko Moji2 1 International Centre for Diarrhoeal Diseases Research, Bangladesh (ICDDR,B), Mohakhali, Dhaka, Bangladesh 2Siebold University of Nagasaki, Nagasaki, Japan Fructooligosaccharide (FOS) is a typical prebiotic agent and reported to be useful in preventing certain disease by stimulating growth of bifidobacteria and lactobacilli in gut. Evaluate the effect of an FOScontaining solution on body weight gain and reductions in diarrhea episodes in peri-urban children in Bangladesh. A randomized, double-masked, placebo-controlled study was conducted on 150 children (25-59 months); 75 received 50 ml of isotonic solution with 2 g of FOS (FOS group), and 75 in the received a similar-looking solution (placebo group) once daily over six months. Body weights and heights were monitored on alternate days and once every month respectively, and the children’s mothers were interviewed to obtain history of diarrhea, stool consistency and contents, other morbidities and antibiotic treatment. The number of diarrhea episodes was less in FOS group compared to the placebo group. However, the difference was not statistically significant. The total mean days with diarrhea as well as each episodes of
2 5
diarrhea were significantly shorter in the FOS group (3.3 vs. 6.3 d, p=0.039 and 2.5 vs. 3.2 d, p=0.008, respectively). The body weight gain during the six-month period in the FOS group (0.86±0.55 kg) and the placebo group (0.89±0.48 kg) was not significantly different, and so were the height and the mid-arm circumference. A daily intake of FOS shortens duration of diarrhea episodes, but is not useful in promoting weight gain or in preventing diarrhea. Further studies with optimizing doses of FOS are needed to define better therapeutic effects in children.
Effect of Diabetic Retinopathy (DR) Education on 51. Knowledge and Planned Lifestyle Activities S. Stastnv, J. Garden-Robinson, L. Youd. North Dakota State University A pilot study to test a new educational program based on current research on DR and diet was developed and tested. DR is seen in 40- 45% of Americans diagnosed with diabetes. It is the leading cause of new cases of blindness in adults. Since DR may have no easily recognizable symptoms it is important for healthcare providers, such as ophthalmologists, optometrists, and dietitians, as well as those with diabetes to be aware of the disease and how to prevent and treat it. Currently a diet for DR does not exist although there are diet recommendations for controlling blood glucose, blood pressure, and lipids. Participants in one group completed a pre- and post-questionnaire prior to and after an educational program in a face-to-face classroom. Participants in the control group completed a pre- and post-questionnaire, after reading a brochure on DR and diet. Knowledge and awareness of DR increased after an educational program and after reading a brochure (p= 0.0 I 6). There was no significant interaction between and within subjects for mean scores to determine if there was a difference in learning (p=0.486). Planned lifestyle activities, such as increased consumption of fruits and vegetables and physical activity, and less consumption of high sodium foods, increased after completion of both instructional options. The classroom program including interactive activities such as the Idaho Plate Method, scripted PP slides, and questionnaires will be useful as part of a statewide educational curriculum, following a train-the trainer approach.
Dose-related Effects of Pistachios on Plasma Sterol 52. Levels in Moderately Hypercholesterolemic Individuals Holligan SI, Gebauer SK2, West SG3, Kay CD4, Kris-Etherton PMI ‘Department of Nutritional Sciences, 3Department of Biobehavioral Health, The Pennsylvania State University, University Park, PA. 2Beltsville Human Nutrition Research Center, Agticultural Research Service, USDA, Beltsville, MD. 4School of Medicine, University of East Anglia, Norwich, UK. Pistachios are a source of plant sterols, which compete with cholesterol for absorption; increased sterol absorption lowers cholesterol synthesis. We conducted a controlled feeding study to determine the dose-related effects of pistachios on plasma sterol levels in individuals (N=28) with moderately elevated LDL-C levels (2: 2.86 mmol/L). Three diets (2100 kcalJd; SFA ~ 8%; cholesterol < 300 mg/dI) studied were: Step I diet (CON; 25% total fat); a Iowdose pistachio diet (1 PD) with 32-63 gld pistachios (CON + 10% energy from pistachios, 30% total fat); or a high-dose pistachio diet (2 PD) with 63-126 gl d pistachios (CON + 20% energy from pistachios, 34% total fat). Plasma levels of desmosterol, lathosterol, beta-sitosterol, and campesterol
were assayed. We report increases in beta-sitosterol levels in the 2PD versus the IPD (p < 0.05), in the 2PD versus the CON (P < 0.001), and in the IPD versus the CON (P < 0.001). Campesterollevels in the CON were higher than the IPD (P < 0.05) and 2PD (P < 0.05) with no difference between IPD and 2PD. Since pistachios provide 200 mg of beta-sitosterol versus 10 mg of campesterol in 100 g, inclusion of pistachios may result in increased beta-sitosterol absorption over campesteroL. There were no effects of diet on desmosterol or lathosterol levels. We previously found that the 1 PD and 2 PD decreased LDL-C levels by 9% and 12% respectively. Tncreased sterol absorption from the pistachio diets may reduce dietary cholesterol absorption, providing a mechanism for reducing plasma cholesterol levels. Funding provided by The Western Pistachio Association and the General Clinical Research Center of The Pennsylvania State University (NIH grant MOIRRI0732).
Vegetable Protein Diets and Cancer Cell Growth: Effect of Oxidized Products and Intracellular Cholesterol Srichaikul K., Jenkins D., Esfahani A, Bashyam B., Kendall C. Department of Nutritional Sciences, University of Toronto, ON. M5S 3E2 Vegetable proteins are good sources of antioxidants and may also reduce LDL-C. Oxidative damage and intracellular cholesterol reduction may promote cell growth. Therefore, we assessed the effect of serum from subjects on diets enriched with barley protein compared to casein on in vitro cancer cell growth. 23 subjects completed a randomized cross over trial of barley protein (30 g/2,000 kcal) or casein supplementation for 4 weeks with a 2 week washout. Prostate (LNCaP) and Breast (MCF-7) cancer cell lines were incubated with study serum (10%) from weeks 0 and 4 to determine in vitro cancer cell growth. No treatment differences were seen. However, serum oxidized LDL concentrations related positively to MCF-7 proliferation (conjugated dienes adjusted for LDL (CD: LDL), r = 0.37, n=44, p<0.013, TBARS:LDL, r = 0.45, n = 42, p = 0.003, and TBARS, r = 0.31, p = 0.045) and reduced LDL-C:HDL-C as a marker of low intracellular cholesterol (r = 0.37, n =44, p = 0.016). Similarly, LNCaP proliferation was enhanced by oxidation of serum protein (thiol destruction) (r = -0.36, n =44, p =0.016) and oxidized LDL-C (CD:LDL, r = 0.42, n = 44, p = 0.005). We therefore conclude that oxidative stress and low intracellular cholesterol concentrations may enhance cancer cell growth, although vegetable protein supplementation was without effect. Funding Source(s): Canadian Institutes of Health Research.
Worldwide Epidemic of Vitamin D Deficiency 53. Sunil J. Wimalawansa, MD, PhD, MBA, Professor of Medicine, Endocrinology & Nutrition, department of Medicine, UMDNJ-RWJMS, New Brunswick, NJ Vitamin D deficiency is increasing worldwide. Human existence is dependent upon exposure to sunlight. While the ultraviolet rays provide more than 80% of our vitamin D requirement, diet and supplements can augment it. An additional 1,000 IU of vitamin D/day is generally sufficient for lighter-skinned individuals, whereas older people and dark-skinned individuals may need an extra 2,000 IU/day to maintain normal serum 25-hydroxyvitamin D [25(OH)D] levels. Measurement of serum 25(OH)D is the most reliable
2 6
way to evaluate vitamin D status. Rickets in childhood and osteomalacia in adults are classic manifestations of severe vitamin D deficiency. Low vitamin D levels may induce cancer, metabolic syndrome, infectious diseases, and autoimmune disorders (i.e., non-skeletal effects). In addition to enhancing calcium absorption from the intestine and mineralization of the osteoid tissue, vitamin D is important in many other physiological effects, including neuro-modulation, muscle strength and coordination, release of insulin, immune health, and curtailing cancer. Whether widespread vitamin D deficiency is related to the increasing incidences of cancer, type 2 diabetes, obesity, and heart disease remains to be determined. The relationship of vitamin D to the skeletal and non-skeletal systems and the significance of non-classic functions and targets of vitamin D need further studies.
Diets High in Saturated Fat Increase Risk for IBD 54. in Genetically Susceptible Hosts via Induction of Immunogenic Microflora Suzanne Devkota1,2, Yunwei Wang2, Dion Antonopoulos3, Eugene B. Chang1,2. Committee on Molecular Metabolism and Nutrition1, Department of Medicine, Section of Gastroenterology2, Institute for Genomics and Systems Biology3, The University of Chicago and Argonne National Laboratory, Chicago, IL. Inflammatory Bowel Diseases (IBD) affect over 1.4 million Americans with 30,000 newly diagnosed cases per year and no known cure. Diets high in saturated fat (SF) have been linked with increased risk for IBD, although potential mechanisms underlying this association have not been identified. Pilot data in conventional mice showed a high SF diet promotes the growth of Bilophila wadsworthia (B.wad), a non-abundant proteobacteria that produces genotoxic hydrogen sulfide, which led to development of colitis. This study elucidates the mechanism by which high SF diets confer B.wad’s immunogenicity. Germ-free (GF) IL10-/- mice were adapted to either a low fat (LF) or SF diet and gavaged with a pure strain of B.wad. After 5 wk B.wad survived only in mice consuming the SF diet, with none surviving in LF mice. ELISA and FACS analyses of proinflammatory cytokines in colonic mucosa and mesenteric lymph nodes displayed elevated IL12p40, IL12p70, and IFN, and low level IL6, TNF, and IL17 in only the SF+B.wad mice. This suggests B.wad strongly polarizes T-cells toward a local Th1 immune response- a hallmark of overt colitis. The control group, GF IL10-/- mice consuming the LF or SF diet without B.wad gavage, showed no such immune response. This is the first study to demonstrate SF-induced B.wad growth provides a significant risk factor for developing IBD in a genetically susceptible host. Supported by National Institues of Health T32 and F31.
Effect of Vitamin A Supplementation on Re-vaccination 55. to Hepatitis B Vaccine Among Rural Infants and Young Children in China. Zhixu Wang, Zhongqing Sun, Aiqin Ma. The Department of Nutrition, School of Public Health, Nanjing Medical University, Nanjing, China. The effect of vitamin A (VA) supplementation on revaccination to Hepatitis B virus (HBV) among rural children in China was observed in this study. All 7~36 month old children who had been vaccinated with obligatory HBV vaccines from 10 villages in Linyi were
convened in October 2008. By detecting serum anti-HBV, one hundred children with lower serum anti-HBV were picked out for a randomized, double blind, placebo controlled VA supplementation study. The intervention was supplementation of 0.5g condensed fish-liver oil (containing 25000 IU retinol) at 15 day interval for 3 months. The control group was given corn-oil. All children were re-vaccinated with 5μg recombinant yeast-derived HBV vaccine by intramuscular injection at 30th and 60th day of the experiment. The serum samples were collected at 90th day of the experiment. Serum retinol and anti-HBs were analyzed with HPLC and ECLIA, respectively. Total 74 children finished the experiment. Before the intervention, the two groups had similar serum retinol level. After intervention, serum retinol increased significantly (404.1±123.1μg/L) compared with the controls (240.8±92.8 μg/L) (P<0.01). The supplemented children presented higher serum anti-HBs to re-vaccination (2737.2±2492.6 vs 1199.7±2141.6 mIU/ml, P<0.01) than the controls. The results show that VA supplementation may enhance the re-vaccination reaction against HB vaccine in the children. This study was financially supported by the Nestlé Foundation.
Eating Disorders, Anorexia and Bulimia in Medical 56. Clinical Nutrition Medical School of Ribeirao Preto, University of Sao Paulo, São Paulo Brazil. Anorexia nervosa and bulimia are eating disorders characterized by voluntary abstention and compulsive ingestion of food. Both pathologies are related once they present symptoms in common.: a prevalent idea involving excessive preoccupation about weight, a distortion of body image, and a pathological fear of gaining weight. The profile of our patients with eating disorders is: white female adolescents who have a high social, cultural and economic status. As far as the etiopatogeny of anorexia nervosa a multifactor model is believe to exist including family, social, cultural psychological, genetic and biological factors. From the nutritional point of view the patients are undernourished, sometimes have edema, hypochromic anemia with leucopenia, increased total cholesterol or decreased cholesterol and triglycerides when undernourished. In general they are hypoglycemic, have low protein and albumin, low mineral and vitamins are low body mass. We have followed these patients from the clinical nutritional point of view, how such conditions start, criteria for their diagnosis, clinical differences of bulimia and anorexia. Considering the prevalence and morbidity of such syndromes their care and study have been the objective since 1980, of our medical nutrition specialized group, which include physicians nutrition specialists, psychologists, psychiatrics, nutritionists and occupational therapists. Funded by Fundacao SIBAN - Brazil.
Seasonal Variation in Eclampsia and Pre-Eclampsia in 57. West Michigan: A Review of Over 39,000 Deliveries from 2005 to 2010 Mark L. Gostine, MD and Fred N. Davis, MD Michigan State University College of Human Medicine Western Michigan is one of the cloudiest areas in the country receiving only 60 fully sunny days per year almost all in the months of May through September. Previous reports revealed that chronic pain patients were markedly vitamin D deficient in this environment during the
2 7
winter1. We analyzed over 39,000 diagnostic codes for the pregnancy induced hypertension states (PIH) of eclampsia and pre-eclampsia during labor and delivery from 2005 through 2010 to see if there was a seasonal variation implying an influence of vitamin D levels on pregnancy complications. PIH was 30 percent more common in the period extending from November through April when compared to June through September. When comparing the absolute monthly zenith and nadir the difference approaches 50%. The steady decline in PIH during the summer months beginning in May through September mirrors the increase in vitamin D levels expected during the summer season in west Michigan and suggests that vitamin D deficiency may be related to pregnancy induced hypertension. 1) Practical Pain Management; Gostine and Davis; July 2006, Volume 6 Issue 5 0 20 40 60 80 100 120 January, February, March, April, May, June, July, August, September, October, November, and December Series1.
Parkinson Disease Therapy with a Vegan Diet and a 58. Gradually Decreasing L-dopa Intake Richard W. Hubbard, Ph,D., M.S., N.R.C.C., CNS., Dept. of Nutritiion, Sch. Of Public Health Lorna Linda University An all plant (vegan) human diet will supply a high fiber, high antioxidant, low saturated fat, and low but adequate protein intake compared to the usual standard American diet (SAD). This plant diet approach results in a significantly lower blood leukocyte, lymphocyte and platelet counts and lower concentrations of complement factor 3 and blood urea nitrogen but higher serum albumin concentrations plus a higher red blood cell count(l). This high albumin level clearly indicates a non anemic balance. An easily achievable consumption of plant proteins with a vegan diet, has measurable protective effects against chronic degenerative diseases (2). It appears that long-term consumption of the low-fat whole-food vegan diet, accompanied by regular aerobic exercise training may at least modestly increase maximal life span in humans by downregulating plasma levels of insulin and free IGF-I (3). It even works for ex-president Bill Clinton, as reported in the daily San Bernardino Sun Telegraman newspaper. Plant proteins have a reduced content of essential amino acids in comparison to animal proteins. However, scientific advances in the last decades have considerably changed the role that vegetarian diets may play in human nutrition. Components of a healthy vegetarian diet include a variety of vegetables, fruits, whole grains, legumes and nuts, and quantifiable benefits of the different components of vegetarian diets, namely the reduction of risk of many chronic degenerative diseases, such as coronary heart disease (CHD), diabetes” obesity, and many cancers. Hence whole foods of plant origin seem to be beneficial on their own merit for chronic disease prevention. This is possibly even more certain than the detrimental effects of milk and meats as causal chronic disease risks. Vegetatarian diets, as in any other diet patterns, may have potential health risks, namely marginal intake of essential nutrients. Also, milk has now been shown to be a causative agent that is linked to Parkinson’s disease.
Stop by the Almond Board of California-sponsored coffee breakon SATURDAY, FEBRUARY 26, 2011, AT 10:00 A.M. Meet our representative and learn about our new helpful teaching tools for health professionals.
© 2011 Almond Board of California. All rights reserved.
BE SURE TO PICK UP YOUR ONE-OUNCE PORTION ALMOND TIN AND LEARN MORE ABOUT THE “CASE FOR 23.”
UPDATE YOUR
PATIENT EDUCATION MATERIALS
ALMH100420_ASN Ad.indd 1 2/16/11 2:27 PM
Exhibits Guide
2 8
T A B L E 6American Institute for Cancer Research1759 R St., NWWashington, DC 20009P H O N E 202-328-7744FA X 202-328-7226 W E B S I T E www.aicr.org
The American Institute for Cancer Research is a non-profit organization focusing exclusively on diet, nutrition, physical activity and cancer. Our mission is to fund research and to increase the awareness and understanding of the role of diet, nutrition and physical activity in cancer prevention and treatment, both for the scientific community and the general public.
T A B L E 10Bariatrix Nutrition Corporation40 Allen RoadSouth Burlington, VT 05403P H O N E 800-468-3438 or 802-862-9306FA X 802-862-9306W E B S I T E www.bariatrix.com Since 1978 Bariatrix Nutrition has been a leader in the development and manufacture of innovative, high quality, functional food products. Our focus is protein rich, low calorie products that are easily integrated into any weight management program. In addition, we offer expert resources compiled by leading professionals in the industry.
T A B L E 9California Walnut Board101 Parkshore Drive, Suite 250Folsom, CA 95630P H O N E 916-932-7070FA X 916-932-7071W E B S I T E www.walnuts.org
Eating a handful of walnuts everyday is an easy way to improve your diet and your health. Stop by our table to learn about heart healthy, versatile and delicious California walnuts. Visit www.walnuts.org/RD for patient education materials and recipes.
T A B L E 4CornSugar.com1701 Pennsylvania Avenue, NW, Suite 950Washington, D.C. 20006P H O N E 202-331-1634FA X 202-331-1054W E B S I T E www.CornSugar.com CornSugar.com features views from health and nutrition experts about the natural sugar made from corn, high fructose corn syrup. Whether it’s corn sugar or cane sugar, your body can’t tell the difference.
T A B L E 14Dyets2508 Easton AvenueBethlehem, Pennslyvania 18017 P H O N E Outside 610 Area Code 1-800-275-3938 Within 610 Area Code 868-7701 FA X 1-610-868-5170W E B S I T E www.dyets.com
DYETS Inc. prepares standards and custom modified cereal based, purified and L-AA diets, on a per order basis, for clients worldwide. DYETS also carries a full line of vitamin and mineral mixtures, liquid diets, drinking tubes and diet mixing equipment. DYETS also offers gamma irradiation services for all powdered, pelleted and liquid diets. Please call for further information regarding diet formulation, pricing and delivery schedules.
T A B L E 8NIH Office of Dietary Supplements1803 Research Blvd., Ste. 301Rockville, MD 20850P H O N E (301)315-2851W E B S I T E http://ods.od.nih.gov The mission of the NIH Office of Dietary Supplements (ODS) is to strengthen knowledge and understanding of dietary supplements. ODS stimulates and supports research, evaluates scientific information, and educates researchers, healthcare providers, and consumers about dietary supplements to promote health. Visit booth #8 to explore the ODS Web site, http://ods.od.nih.gov. A variety of educational materials will be available.
2 9
T A B L E 7Proliant Health and Biologicals 2425 SE Oak Tree Ct. Ankeny, IA 50021 P H O N E 515-289-7600 FA X 515-289-4360 W E B S I T E www.ImmunoLin.com Proliant Health and Biologicals manufactures and sells ImmunoLin, a high quality bioactive protein used for digestive health and immune modulation. ImmunoLin is a highly concentrated non-dairy source of serum-derived immunoglobulins, antibodies and immunoproteins. It contains three times more immunoglobulin than colostrum and ten times more immunoglobulin than whey.
T A B L E 12Tomato Products Wellness CouncilP H O N E 831.254.5405W E B S I T E http://www.TomatoWellness.com Tomato products are healthy, affordable and popular in a variety of cuisines. At www.TomatoWellness.com an updated research summary helps to understand the protective effects of tomato consumption on cancer, cardiovascular disease, diabetes, body weight management, skin, bone and brain function.http://www.facebook.com/tomatoproductswellnesscouncil
T A B L E 5U. S. Food & Drug Administration1431 Harbor Bay ParkwayAlameda, CA 94502-7070P H O N E 510-337-6845W E B S I T E www.fda.gov Free consumer education materials on nutrition labeling, dietary supplements, health fraud, reporting problems to the FDA, and other topics of interest to the nutrition community will be available.
T A B L E 11Yakult USA3625 Del Amo Blvd., Suite 260 Torrance, CA 90503P H O N E 310-542-7065FA X 310-542-7045W E B S I T E http://www.yakultusa.com Yakult is one of the world’s leading probiotic beverages created in 1935 in Japan by microbiologist Dr. Minoru Shirota to help people maintain good digestive health. Today, Yakult is enjoyed by 28 million people daily in 32 countries. The company’s U.S. headquarters is located in Torrance, CA.
Exhibits Guide
Advances and Controversies in Clinical Nutrition 2011 Wyndham Parc 55, San Francisco, CA USA
14 13 12 11 10 9 8 7 456 123
E X H I B I T S F L O O R P L A N
Upcoming Meetings & Events
3 0
EB Pre-Conference: The Global Nutrition Translation: The Role of Protein Supplementation, April 7, 2011, Washington, DC
EB Pre-Conference: Heart Healthy Omega-3s for Food: Stearidonic Acid as a Sustainable Choice, April 8, 2011, Washington, DC
2011 ASN Scientific Sessions and Annual Meeting at Experimental Biology April 9-13, 2011, Washington, DC American Society for Nutrition (ASN) and the Nutrition Society (UK) Nutrition Society Irish Section Meeting 2011: Vitamins in Early Development and Healthy Aging: Impact on Infectious and Chronic Disease, June 15-17, 2011, at University College Cork, Ireland
American Society for Nutrition’s (ASN) Pre-conference at the American Dairy Science Association (ADSA) and American Society of Animal Science (ASAS) Joint Annual Meeting, July 9, 2011, New Orleans, LA
2011 ASN Scientific Sessions and Annual Meeting at Experimental BiologyApril 21-25, 2012, San Diego, CA
Lists are current at press time; please check www.nutrition.org/edprofdev for details and updates.
EXPERIENCE EB IN THE NATION’S CAPITAL
®2011
2011 ASN SCIENTIFIC SESSIONSAND ANNUAL MEETINGApril 9-13 • Washington, D.C. in conjunction with Experimental Biology
ASN Preliminary Program (visit the ASN website at www.nutrition.org/meetings/annual for the most up-to-date information, including our late-breaking sessions)
EXPLORE DC
EXPERIENCE EB
EXPLORE HISTORY
EXPERIENCE EB
Deadline: monday, February 9, 2011 www.experimentalbiology.org
Deadline: monday, February 9, 2011 www.experimentalbiology.org
Scientific sessions, networking events, RIS and more: [email protected]
EARLY REGISTR ATION
L ATE-BREAKING ABSTR AC T SUBMISSION
SPONSORSHIP OPPORTUNITIES
www.nutrition.org/meetings/annualASN PROGR AM
Friday, April 8, 2011• Pre-Conference: Heart Healthy Omega-3s for Food: Stearidonic Acid (SDA)
as a Sustainable Choice
Saturday, April 9, 2011• Special Session/Special Conference: Functional foods for health
promotion: Moving beyond “Good Fat, Bad Fat”—the complex roles of dietary lipids in cellular function and health
• Novel integrative research on the brain basis of human food intake and obesity.
Sunday, April 10, 2011• The Presidential Symposium: Ameliorating micronutrient deficiencies
through biofortification: The science and prospects.• CARIG: Biofortification of provitamin A in maize for Africa.• Ethical issues in nutrition research.• Maternal obesity and long-term programming of obesity risk.• The 2010 Dietary Guidelines for Americans: New process,
recommendations, and implications for the future.• Workshop: The GPEC Educational Forum: Integrating nutritional genomics
and nutritional genetics in the 21st century nutrition curriculum. Monday, April 11, 2011• Workshop: Genetic polymorphisms as sources of nutritional/metabolic
variation—a methods workshop.• Assessing the effects of bioactives in humans: Establishing the framework
for an evidence-based approach.• Building convergence among scientific, programmatic and policy commu-
nities working on childhood undernutrition in developing countries.• Is ‘processed’ a four letter word?—the role of processed foods in achieving
dietary guidelines and nutrient recommendations in the US.• Education and Professional Development Session: Training nutrition
educators for the health professions.• Metabolic regulation and immune cells: Implication for chronic and
infectious diseases. Tuesday, April 12, 2011• Impact of maternal nutritional status on breast milk quality and infant
outcomes: an update on key nutrients.• Food aid commodities: Optimum micronutrient composition and best
programmatic uses.• Minority Affairs Committee (MAC)
Health disparities in early nutrition: Where the problem begins?• SIG Special Session: The changing face of nutrition in the United States:
How nutrition policy and consumer awareness are changing the practice of nutrition and food science.
• The global beverage picture: Where is the science today as beverage consumption relates to cardiometabolic health?
Kraft Foods proudly supportsthe American Society for Nutritionin advancing the knowledge of nutritionas we work to make the foods people love even better!
C
M
Y
CM
MY
CY
CMY
K
Kraft Nutrition Ad full page.pdf 1 2/16/2011 11:01:56 AM