Adhesion Adhesion molecules and molecules and

lymphocyte lymphocyte hominghoming 成员：艾戈弋、鲍梦馨、车飞、陈超、成员：艾戈弋、鲍梦馨、车飞、陈超、董丽花、姜琳董丽花、姜琳

reviewreview

Definition of adhesion Definition of adhesion molecules molecules

Cell adhesion molecules (CAMs) are Cell adhesion molecules (CAMs) are cell surface proteins involved in the icell surface proteins involved in the interaction of cell-cell or cell-extracelnteraction of cell-cell or cell-extracellular matrix. lular matrix.

CAMs take effect by the binding of reCAMs take effect by the binding of receptor and ligand ceptor and ligand

ClassificationClassification

Integrin familyIntegrin family Selectin family Selectin family Immunoglobulin (Ig) superfamilyImmunoglobulin (Ig) superfamily Cadherin family Cadherin family Mucin-like familyMucin-like family Other adhesion moleculesOther adhesion molecules

IntegrinsIntegrins

SelectinSelectin

ISFISF

CadherinCadherin

Lymphocyte homingLymphocyte homing

The directed migration of subsetThe directed migration of subset

s of circulating lymphocytes into s of circulating lymphocytes into particular tissue sites.particular tissue sites.

ClassificationClassification

Lymphoid stem cell migrate to Lymphoid stem cell migrate to central lymphoid organscentral lymphoid organs

Mature lymphocyte migrate to Mature lymphocyte migrate to peripheral lymphoid organsperipheral lymphoid organs

Recirculation of lymphocytesRecirculation of lymphocytes Lymphocyte migrate to the sites Lymphocyte migrate to the sites

of inflammation of inflammation

How adhesion How adhesion molecules molecules

participate in participate in homing ?homing ?

Adhesion molecules Adhesion molecules mediate the process of mediate the process of

hominghoming Lymphocyte homing receptor (LHR) Lymphocyte homing receptor (LHR)

express on lymphocyteexpress on lymphocyte

Addressin Addressin

express on vascular endothelial cellexpress on vascular endothelial cell

Adhesion Molecules on Adhesion Molecules on LymphocyteLymphocyte

lymphocytlymphocyte adhere, e adhere, penetrate penetrate vascular vascular

endotheliaendothelial celll cell

Adhesion molecules Adhesion molecules participate in lymphocyte participate in lymphocyte

hominghomingLymphocyte homing receptor Lymphocyte homing receptor Addressins Addressins AdhesioAdhesion n moleculmoleculeses

FunctionsFunctions AdhesioAdhesion n moleculmoleculeses

FunctionsFunctions

L-selectiL-selectin n

Lymphocyte homing Lymphocyte homing to peripheral immune to peripheral immune organs organs

PNAdPNAd 　 　 Addressin of Addressin of peripheral high peripheral high venous endothelial cell venous endothelial cell

CLA CLA Receptor on memory Receptor on memory T cell surface for T cell surface for directionally homing directionally homing to skin to skin

E-E-selectin selectin

Express on vascular Express on vascular endothelial cell of endothelial cell of inflammation portion inflammation portion of skin of skin

LFA-1 LFA-1 Participate in many Participate in many lymphocytes for lymphocytes for homing homing

ICAM-1ICAM-1

ICAM-2 ICAM-2 Participate in many Participate in many lymphocytes for lymphocytes for homing homing

Adhesion molecules Adhesion molecules participate in lymphocyte participate in lymphocyte

hominghomingLymphocyte homing receptor Lymphocyte homing receptor Addressins Addressins AdhesioAdhesion n moleculmoleculeses

FunctionsFunctions AdhesioAdhesion n moleculmoleculeses

FunctionsFunctions

VLA-4 VLA-4 Receptor of Receptor of lymphocyte homing lymphocyte homing

VCAMVCAM －－1 1

Express on vascular Express on vascular endothelial cell of endothelial cell of inflammation portion inflammation portion

CD44 CD44 Participate in many Participate in many lymphocytes homing lymphocytes homing

MAdMAd Intestinal lymphatic tissIntestinal lymphatic tissue and lamina propria ue and lamina propria

integrin integrin Receptor of lymphocytReceptor of lymphocyte for directionally mige for directionally migrate to Peyre's Patch rate to Peyre's Patch

MAdMAd 　 　 Addressin of vascular Addressin of vascular endothelial cell endothelial cell

α4β7α4β7

Adhesion molecules in Adhesion molecules in normal condition in normal condition in lymphocyte hominglymphocyte homing

Pro-T cell migrate to Pro-T cell migrate to thymus thymus

Homing receptorHoming receptor: : CD44CD44 and and L-selectinL-selectin expressed by pro-T cell expressed by pro-T cell

AdressinAdressin: : EA1EA1 molecule expressed by t molecule expressed by thymus vascular endothelial cell hymus vascular endothelial cell

And integrin And integrin α6β1α6β1 、、 α6β4α6β4 play an imp play an important role in adhesion of pro-T cell ortant role in adhesion of pro-T cell

Lymphocyte migrate to Lymphocyte migrate to peripheral lymphoid organs peripheral lymphoid organs Lymphocytes migrate to lymph nodeLymphocytes migrate to lymph node

Homing receptorHoming receptor: : L-selectinL-selectin on lymphocyte on lymphocyte AdressinAdressin ：： peripheral lymphonode vascular addperipheral lymphonode vascular add

ressin (ressin (PNAdPNAd) )

LFA-1LFA-1//ICAM-1ICAM-1 、、 ICAM-2ICAM-2 and and CD44CD44//Mad Mad molecmolecules participate in the adhesion and penetration ules participate in the adhesion and penetration

Lymphocyte migrate to Peyer’s PatcLymphocyte migrate to Peyer’s Patchh

Homing receptorHoming receptor: integrin : integrin α4β7α4β7 molecule molecule ； ； CD4CD444 and and LFA-1LFA-1 molecules molecules

AdressinAdressin: Vascular endothelial cell of peyre’s pa: Vascular endothelial cell of peyre’s patch specifically highly express mucosal vascular tch specifically highly express mucosal vascular addressin (addressin (MadMad); ); ICAM-1ICAM-1 、、 ICAM-2ICAM-2

Peyre’s patch means the aggregated lymphoid Peyre’s patch means the aggregated lymphoid nodule in small intestine.nodule in small intestine.

Lymphocyte migrate to Lymphocyte migrate to peripheral lymphoid organs peripheral lymphoid organs

Lymphocyte Lymphocyte hominghoming

Adhesion molecules in Adhesion molecules in pathological condition pathological condition

(inflammation) in (inflammation) in lymphocyte hominglymphocyte homing

Function of adhesion Function of adhesion molecules in inflammationmolecules in inflammation

Lymphocyte migrate to Lymphocyte migrate to inflammation of skin inflammation of skin

Homing receptorHoming receptor: cutaneous lymphocyt: cutaneous lymphocyte-associated antigen (e-associated antigen (CLACLA)) ；； VLA-4VLA-4 ；；LFA-1LFA-1

AdressinAdressin: E-selectin : E-selectin ；； VCAM-1VCAM-1; ; ICAICAM-1M-1//ICAM-2ICAM-2

Lymphocyte migrate to Lymphocyte migrate to inflammation of skin inflammation of skin

Lymphocyte migrate to Lymphocyte migrate to inflammation of intestinal inflammation of intestinal

mucosa mucosa

Molecule expressed by lymphocyte Molecule expressed by lymphocyte of intestinal mucous tissue called of intestinal mucous tissue called mucosal lymphocyte antigen (mucosal lymphocyte antigen (MLAMLA))

Lymphocyte migrate to inflamLymphocyte migrate to inflammation of synovium mation of synovium

Homing receptorHoming receptor: : LFA-1 LFA-1 ; ; VLA-4 VLA-4 ; ; CD44CD44

AdressinAdressin: : ICAM-1ICAM-1 ；； VCAM-1VCAM-1 ；； MadMad

DiseaseDisease

Hyper-expressing adhesion Hyper-expressing adhesion molecules molecules

Hypo-expressing adhesion moleculesHypo-expressing adhesion molecules

HoHowevwever…er…

more mechanism more mechanism needneeded to be ed to be explored…explored…

Thank youThank you