addressing the unmet need in nonalcoholic steatohepatitis

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Addressing the Unmet Need in Nonalcoholic Steatohepatitis

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Addressing the Unmet Need in Nonalcoholic Steatohepatitis. NAFLD Hepatic Manifestation of Metabolic Syndrome a. NAFLD (cont) Hepatic Manifestation of Metabolic Syndrome a. NAFLD/NASH Closely Associated With Visceral Obesity, Insulin Resistance. - PowerPoint PPT Presentation

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Page 1: Addressing the Unmet Need in Nonalcoholic Steatohepatitis

Addressing the Unmet Need in Nonalcoholic Steatohepatitis

Page 2: Addressing the Unmet Need in Nonalcoholic Steatohepatitis
Page 3: Addressing the Unmet Need in Nonalcoholic Steatohepatitis

NAFLDHepatic Manifestation of Metabolic

Syndromea

Page 4: Addressing the Unmet Need in Nonalcoholic Steatohepatitis

NAFLD (cont)Hepatic Manifestation of Metabolic

Syndromea

Page 5: Addressing the Unmet Need in Nonalcoholic Steatohepatitis

NAFLD/NASH Closely Associated With Visceral Obesity, Insulin

Resistance

Page 6: Addressing the Unmet Need in Nonalcoholic Steatohepatitis

AASLDCurrent Therapeutic Recommendations for

NAFLD/NASH

Page 7: Addressing the Unmet Need in Nonalcoholic Steatohepatitis

Pioglitazone vs PlaceboSignificant Improvement of Histologic Features

and Insulin Sensitivity

Page 8: Addressing the Unmet Need in Nonalcoholic Steatohepatitis

11β-HSD1 Inhibitor RO5093151 Inhibits Adipocyte Differentiation

Page 9: Addressing the Unmet Need in Nonalcoholic Steatohepatitis

Galectin-3 Binding Drug GR-MD-02 Inhibits Hepatic Injury in Mouse

Model

Page 10: Addressing the Unmet Need in Nonalcoholic Steatohepatitis

Obeticholic Acid Improves Insulin Sensitivity and Markers of Liver

Injury

Page 11: Addressing the Unmet Need in Nonalcoholic Steatohepatitis

Selective Serotonin 2C Receptor Agonists Aid Weight Loss

Page 12: Addressing the Unmet Need in Nonalcoholic Steatohepatitis

Phentermine and Topiramate ER, an STR, Improves Weight Loss

Page 13: Addressing the Unmet Need in Nonalcoholic Steatohepatitis

Incretin Mimetics and Analogs Aid Maintenance of Glucose Balance

Page 14: Addressing the Unmet Need in Nonalcoholic Steatohepatitis

Abbreviations

Page 15: Addressing the Unmet Need in Nonalcoholic Steatohepatitis

References

Page 16: Addressing the Unmet Need in Nonalcoholic Steatohepatitis

References (cont)

Page 17: Addressing the Unmet Need in Nonalcoholic Steatohepatitis

References (cont)