acrin annual meeting 2011 mitchell schnall md, phd professor of radiology university of pennsylvania...

ACRIN Annual Meeting 2011

Mitchell Schnall MD, PhDProfessor of RadiologyUniversity of PennsylvaniaACRIN Network Chair

State of ACRIN : Extending our reach


ACRIN Scientific Strategy

1. Develop and evaluate strategies for imaging surveillance of populations at high risk for cancer.

2. Develop and validate imaging biomarkers to predict and monitor therapy response.

3. Evaluate the effectiveness of imaging directed therapy on improving patient management and associated outcomes. This includes comparative effectiveness studies of existing imaging methods.


ACRIN Organizational Chart

Institutional Participants CommitteeVice Chair

Chris Comstock, MDMemorial Sloan Kettering

Institutional Participants CommitteeVice Chair

Chris Comstock, MDMemorial Sloan Kettering

Media / Publications and

DisseminationCommitteeVice Chair

Laurie Fajardo, MDUniversity of Iowa

Media / Publications and

DisseminationCommitteeVice Chair

Laurie Fajardo, MDUniversity of Iowa

Special PopulationsElizabeth Patterson, MD

Special PopulationsElizabeth Patterson, MD

Research AssociatesWendy Smith, RT

Rhode Island Hospital

Research AssociatesWendy Smith, RT

Rhode Island Hospital

Quality ControlMitchell Schnall, MD, PhDUniversity of Pennsylvania

Quality ControlMitchell Schnall, MD, PhDUniversity of Pennsylvania

Patient AdvocacyPeggy Anthony, RN, MHS


Outcomes & Economics Core

LaboratoryWilliam Black, MD

Dartmouth Medical School

Outcomes & Economics Core

LaboratoryWilliam Black, MD

Dartmouth Medical School

Advisory PanelDaniel Sullivan, MD

Duke University

Advisory PanelDaniel Sullivan, MD

Duke UniversityLeadership Council

Mitchell Schnall, MD, PhDUniversity of Pennsylvania

Leadership CouncilMitchell Schnall, MD, PhD

University of Pennsylvania

Biostatistical & Data Management Center

Chair Constantine Gatsonis, PhD

Brown University

Biostatistical & Data Management Center

Chair Constantine Gatsonis, PhD

Brown University

Steering Committee

Network ChairMitchell Schnall, MD, PhD


Deputy Chairs Anat/Fxn ImagingDenise Aberle, MD

UCLA

Molecular ImagingBarry Siegel, MD

Washington University

Steering Committee

Network ChairMitchell Schnall, MD, PhD


Deputy Chairs Anat/Fxn ImagingDenise Aberle, MD

UCLA

Molecular ImagingBarry Siegel, MD


AbdominalTerri Wong, MDDuke University

AbdominalTerri Wong, MDDuke University

Head/Neck/CNSDan Barboriak,, MD

Duke University


Duke University

BreastConnie Lehman, MD

University of Washington

BreastConnie Lehman, MD


ThoracicCaroline Chiles, MDWake Forest University

ThoracicCaroline Chiles, MDWake Forest University

GynecologicalSusanna Lee, MD

Massachusetts General Hosp

GynecologicalSusanna Lee, MD


Disease SiteCommittees

Scientific SupportCommittees

Experimental ImagingDavid Mankoff, MD


Experimental ImagingDavid Mankoff, MD


InformaticsDaniel Rubin, MDStanford University

InformaticsDaniel Rubin, MDStanford University

Core Laboratory

PET/Nuc MedicineBarry Siegel, MD


MR/CTMark Rosen, MD, PhDUniversity of Pennsylvania

Core Laboratory

PET/Nuc MedicineBarry Siegel, MD


MR/CTMark Rosen, MD, PhDUniversity of Pennsylvania

Ultrasound Working Group

Barry Goldberg, MDThomas Jefferson University

Ultrasound Working Group

Barry Goldberg, MDThomas Jefferson University

NCIPaula Jacobs, PhD

Cancer Imaging Program

NCIPaula Jacobs, PhD

Cancer Imaging Program

Network AdministrationCharles Apgar

ACR Philadelphia

Network AdministrationCharles Apgar

ACR Philadelphia

Data & Safety Monitoring Committee

Daniel Sargent, PhDMayo Clinic

Data & Safety Monitoring Committee

Daniel Sargent, PhDMayo Clinic

SupportCommittees

Organizational Changes

Cardiovascular Pam Woodard, MDWashington University

Cardiovascular Pam Woodard, MDWashington University

ACRIN PAMitch Schnall, MD, PhD


ACRIN PAMitch Schnall, MD, PhD


NeuroscienceGreg Sorensen, MD


NeuroscienceGreg Sorensen, MD


ACRIN ProjectsMitch Schnall, MD, PhD


ACRIN ProjectsMitch Schnall, MD, PhD


Non NCI Disease SiteCommittees

ACRIN FoundationJim Thrall, MD

MGH

ACRIN FoundationJim Thrall, MD

MGH


Duke University


Duke University




Highlights: NLST publication

•20% redcution in lung cancer mortality•7% redcution in all cause mortality


Highlights: Study Portfolio

11 open studies 2 Cardiovascular (RESCUE is opened) 9 Oncology (first multicenter optical imaging trial) Comparative effectiveness studies (RESCUE, 6690)

5 concepts in development E2410 trial in collaboration with ECOG Collaboration with QIBA Diffusion MRI in ISPY 2

DECAMP: impact of biomarkers in risk assessment and diagnostics related to lung cancer screening


Highlight: CQIE

Goal: Qualify 59 cancer center in quantitative MRI, CT and PET imaging

Accomplishments 52 sites fully qualified

• CT:57

• PET: 54

• MR: 54


Mid Term Review

“Evaluation Committee members identified the Network as an invaluable national resource worthy of continued support” Screening program rated as exceptional Biomarkers program challenges acknowledged

• Smaller early phase studies

• Focus on compelling clinical problems (practice changing)

• Reduce trial complexity


Cooperative Group Reorganization

Group Consolidation: no more than 4 adult groupsFormation of a “Network”

Harmonization of processesTrans network collaborationNetwork wide prioritization


Implications for ACRIN

ACRIN would not be able to compete on its own for membership in the cooperative group network

Opportunity for developing a formal structure for core support of the cooperative group network


ECOG-ACRIN Alliance

“The groups plan to form an alliance that combines their complementary strengths”

“The new organization will include three areas of research emphasis: early detection and diagnosis of cancer; biomarker-driven Phase II and Phase III therapeutic studies for multiple cancer types and stages; and genetic, molecular and imaging marker research to predict and monitor treatment response.”


Progress

Name Program Structure Collaborative CCOP Research Base grant

submission Joint trial (s) Developing

Membership model Operational model Governance structure


Overall Impact on ACRIN

ACRIN Oncology

ACRIN Cardiology

ACRIN Neuro-

Sciences

ECOG

New Group


ECOG –ACRINCooperative Group, Inc.

BOM

BiostatsDM

Scientific Steering Committee

OPS

TherapeuticsSparano/ACRIN

Biomarker ScienceHamilton/Flaherty/Mankoff

Cancer Control and Outcomes

ECOG ACRIN

DOCEISCLAB SCI

DT

OTHER

PT CENTERED OUTCM/SURVIVWagner/Black

Early DETEC/DX/PREVENTIONKhuri/Schnall

Underserved

SX CER

Outcomes Prev Det/Dx


Process

Initial Presentation to group chairs: Nov 2010 Meeting with Chairs: Jan, March, April, May 2011 Vetting proposal/progress

IOM/ASCO workshop (March 21, 2011) AACR (April 5th, 2011) ASCO, 2011

Developing FOA Aug 2011: internal NCI review Nov 2011: BSA Concept review July 2012: FOA released Nov 2012: Applications due Feb 2013: Review Roll out new awards in 2014


Hopes\Challenges for the Alliance:

The ACRIN Perspective

Strengthen cancer biology expertise contributing to imaging trial development

More effective integration with therapeutic development

Better access to trials with novel targeted therapeutics

Better accrual to imaging biomarker studies

Integrative approach to diagnostics

Engagement of the cooperative group structure in studying the entire cancer care path

Maintaining a scientific focus in early detection/diagnostics

Adapting to the membership structure of the cooperative group network

Maintaining the clinical trial infrastructure in the academic and practice community

Continuing to be nimble enough to aggressively pursue opportunity

Hopes Challenges


Seize the Day!

Opportunity to develop the new model for cooperative group science

Innovative science driven research Multimodality diagnostics Set the imaging agenda

acrin annual meeting 2011 mitchell schnall md, phd professor of radiology university of pennsylvania...

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