about aromatase inhibitors anastrozole, letrozole & exemestane at research liquids
DESCRIPTION
Aromatase inhibitors (AIs) are a class of drugs used in the treatment of breast cancer and ovarian cancer in postmenopausal women. They may also be used off-label to treat or prevent gynaecomastia in men. Aromatase is the enzyme that synthesizes estrogen. As breast and ovarian cancers require estrogen to grow, AIs are taken to either block the production of estrogen or block the action of estrogen on receptors. There are 2 types of aromatase inhibitors (AIs) approved to treat breast cancer: Irreversible steroidal inhibitors Such as exemestane (Aromasin), forms a permanent and deactivating bond with the aromatase enzyme. Non-steroidal inhibitors Such as anastrozole (Arimidex) and letrozole (Femara), inhibit the synthesis of estrogen via reversible competition for the aromatase enzyme. Visit: http://www.researchliquids.comTRANSCRIPT
Aromatase Inhibitors
About
AromataseInhibitors
Aromatase inhibitors (AIs) are a class of drugs used
in the treatment of breast cancer and ovarian
cancer in postmenopausal women. They may also be
used off-label to treat or prevent gynaecomastia in
men.
Aromatase is the enzyme that synthesizes estrogen.
As breast and ovarian cancers require estrogen to
grow, AIs are taken to either block the production of
estrogen or block the action of estrogen on receptors.
Types OfAromataseInhibitors
There are 2 types of aromatase inhibitors (AIs)
approved to treat breast cancer:
Irreversible steroidal inhibitors
Such as exemestane (Aromasin), forms a permanent
and deactivating bond with the aromatase enzyme.
Non-steroidal inhibitors
Such as anastrozole (Arimidex) and letrozole (Femara),
inhibit the synthesis of estrogen via reversible
competition for the aromatase enzyme.
Exemestane
Product
Exemestane
Details:
Exemestane is a steroidal irreversible CYP19
(aromatase) inhibitor. Exemestane is structurally
related to natural androstenedione and acts as a false
CYP19 enzyme substrate. This effect is also known as
"suicide inhibition". Exemestane has been found to
inhibit human placental CYP19. Buy Exemestane of
high quality only at Research Liquids.
Description:
Liquid Exemestane is an irreversible steroidal
aromatase inhibitor (IC50 = 20 nM). Destabilizes
aromatase and lowers estrogen levels.
Targets: Aromatase
Exemestane
Anastrozole
Product
Details:
Anastrozole belongs to a class of compounds known as
aromatase inhibitors. An enzyme known as aromatase is
responsible for producing estrogen by converting androgens
into estrogen. Aromatase inhibitors like Anastrozole prevent
aromatase from fulfilling that role by binding to it and
rendering it inactive. Aromatase inhibitors fall into two
categories: reversible (such as letrozole and Anastrozole )
and irreversible; irreversible aromatase
inhibitors permanently bind to the circulating aromatase
complex. Buy Anastrozole of high quality only at Research
Liquids.
Exemestane
Description:
Liquid Anastrozole is a third-generation nonsteroidal
selective aromatase inhibitor.
Targets: Aromatase
Exemestane
Letrozole
Product
Details:
Letrozole is a potent, reversible non-steroidal
aromatase inhibitor (IC50 = 11.5 nM). Displays
antitumor effects in several animal models. Suppresses
the endogenous aromatase-induced proliferation of
MCF-7 cells. Buy Letrozole of high quality only at
Research Liquids.
Letrozole
Description:
Liquid Letrozole is a third generation nonsteroidal
CYP19 aromatase inhibitor.
Targets: CYP19
Letrozole
