a multicentric retrospective observational study of the ......long-acting injection antipsychotics...
TRANSCRIPT
L. Orsolini1-4, D. De Berardis2,5,6, A. Carano7, C. Tomasetti2,8, R. Vecchiotti1-3, F. Iasevoli2,8,
G. Martinotti6, A. Valchera1,2 ¹ Villa S. Giuseppe Hospital, Hermanas Hospitalarias, Ascoli Piceno, Italy; 2 Polyedra Research Group, Teramo, Italy; 3 Department of Psychiatry and Neuropsychology, Maastricht University, Maastricht, Netherlands 4 School of Life and Medical Sciences, University of Hertfordshire, Hatfield, Herts, UK; 5 NHS, Department of Mental Health, Psychiatric Service of Diagnosis and Treatment, Hospital “G. Mazzini”, ASL 4 Teramo, Italy 6 Department of Neuroscience, Imaging and Clinical Science, Chair of Psychiatry, University “G. D’Annunzio”, Chieti, Italy; 7 NHS, Department of Mental Health ASL Ascoli Piceno, Psychiatric Service of Diagnosis and
Treatment, Hospital “Madonna del Soccorso”, San Benedetto del Tronto, Italy; 8 Laboratory of Molecular Psychiatry and Psychopharmacotherapeutics, Section of Psychiatry, Department of Neuroscience, University
School of Medicine “Federico II”, Naples, Italy
A multicentric retrospective observational study of the effectiveness of paliperidone palmitate long-acting injection (PP-LAI) on non-core symptoms of schizophrenia
INTRODUCTION Schizophrenia is a severe mental illness that may require the administration of second-generation
long-acting injection antipsychotics (SGA LAIs) to reduce the likelihood of relapse/hospitalization and
allow the maintenance of an adequate treatment. Although SGA LAIs appear to be effective in the
treatment and the improvement of core symptoms (e.g., delusions; disturbances in perception,
abnormalities in communication/behavior/motor activity, and deficits in emotional
expressivity/hedonic capacity/drive) of the illness, no definitive and clear conclusions could be drawn
up on their short-/long-term effects in the improvement of non-core symptoms.
AIMS: The present study aims at conducting a multicentric
retrospective observational study of the effectiveness
of paliperidone palmitate long-acting injection (PP-LAI)
in the following non-core dimensions of schizophrenia:
Copyright © 2016 Orsolini L. et al. Villa San Giuseppe Hospital, Ascoli Piceno; Polyedra Research, Teramo, Italy; and School of Life and Medical Sciences, University of Hertfordshire, Hatfield, Herts, UK. Email:
Social and
working
functioning
OC-
symptoms
Affective
Dimension
Social
Functioning
Scale [SFS]
Clinical
Global
Impression
[CGI]
Short-Form
36 Healthy-
Survey
Questionnai
re [SF-36]
Aggressiveness
and impulsiveness
Y-BOCS
Calgary
Depression
Scale [CDS]
Mania
Rating
Scale [MRS]
Hamilton
Anxiety
Rating
Scale
[HARS]
Hamilton
Depression
Rating
Scale
[HARS]
Aggression
Questionnaire
[AQ]
Barratt
Impulsiveness
Scale[BIS-11]
Compliance and
Treatment
Adherence
Drug Attitude
Inventory
[DAI]
METHODS: All LAI-naïve patients commenced
and currently on PP-LAI for at least 3 months, will
be progressively recruited in a 12-month period.
a) Psychiatric Service of Diagnosis and
Treatment, Hospital “G. Mazzini”, Teramo,
Italy;
b) Psychiatric Service of Diagnosis and
Treatment, Hospital “Madonna del Soccorso”,
San Benedetto del Tronto, Italy;
c) Psychiatric Service of Diagnosis and
Treatment, “Maria SS dello Splendore”,
Giulianova, Italy;
d) Villa San Giuseppe Hospital, Ascoli Piceno,
Italy.
Psychiatric history
Current Psychiatric
status BPRS
PANSS