73. Changing patterns of recurrent disease in colorectal cancer

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<ul><li><p>754 ABSTRACTSTumour response to neoadjuvant therapy ranges from complete response to</p><p>little or no response at all and is related with outcomes. The aim of this</p><p>study was to determine the correlation between clinical, pathological pa-</p><p>rameters and molecular biomarkers in diagnostic endoscopic biopsies</p><p>with tumour regression grading in the resected specimens.</p><p>Materials and methods: Ninety five patients with mid (56%) and low</p><p>(44%) locally advanced rectal adenocarcinoma who received neoadjuvant</p><p>radiotherapy with or without chemotherapy followed by radical surgical</p><p>resection were included in the study. Mean age was 68 years. Sixty four</p><p>(67%) were males and 31 (33%) females. Several clinical and pathological</p><p>parameters were collected. Paraffin-embedded sections obtained in diag-</p><p>nostic biopsies before therapy were assessed by immunohistochemical</p><p>staining for p53, her-2, VEGFr, bcl-2, beta-catenin, COX-2, APAF-1 and</p><p>Ki-67. These stains were correlated with T-downstaging and tumour re-</p><p>gression grade (TRG) using Mandards scoring system on surgical speci-</p><p>mens. Data were analyzed with chi-square and Spearmans correlation</p><p>tests.</p><p>Results: Pathologic complete response was seen in 17% and T down-</p><p>staging in 48.2%. There was correlation between TRG and pretreatment</p><p>expression of bcl-2 (p0.04), beta-catenin (p0.03) and VEGFr(p0.04). T-downstaging was significantly associated with expression ofAPAF-1 (p0.04) and VEGFr (p0.03). We did not find any correlationwith any other molecular marker (p53, her-2, COX-2, Ki-67), clinical</p><p>and pathological parameters (age, gender, tumour location, pretreatment</p><p>CEA level, interval to surgery), excepting histologic grade (p</p></li></ul>