5f-adb critical review report spice, k2, legal weed, synthetic cannabis, herbal incense are common...

5F-ADB

Critical Review Report

Agenda Item 4.2

Expert Committee on Drug Dependence

Thirty-ninth Meeting

Geneva, 6-10 November 2017

39th ECDD (2017) Agenda item 4.2 5F-ADB

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39th ECDD (2017) Agenda item 4.2 5F-ADB

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Contents

Acknowledgements.................................................................................................................................. 5

Summary...................................................................................................................................................... 6

1. Substance identification ....................................................................................................................... 7

A. International Nonproprietary Name (INN).......................................................................................................... 7 B. Chemical Abstract Service (CAS) Registry Number .......................................................................................... 7 C. Other Chemical Names ................................................................................................................................................... 7 D. Trade Names ....................................................................................................................................................................... 7 E. Street Names ....................................................................................................................................................................... 7 F. Physical Appearance ....................................................................................................................................................... 7 G. WHO Review History ....................................................................................................................................................... 7

2. Chemistry ................................................................................................................................................... 8

A. Chemical Name .................................................................................................................................................................. 8 B. Chemical Structure ........................................................................................................................................................... 8 C. Stereoisomers ...................................................................................................................................................................... 8 D. Methods and Ease of Illicit Manufacturing ........................................................................................................... 8 E. Chemical Properties ......................................................................................................................................................... 8 F. Identification and Analysis ........................................................................................................................................... 9

3. Ease of Convertibility Into Controlled Substances ........................................................................ 9

4. General Pharmacology .......................................................................................................................... 9

A. Routes of administration and dosage ...................................................................................................................... 9 B. Pharmacokinetics ............................................................................................................................................................. 9 C. Pharmacodynamics ....................................................................................................................................................... 10

5. Toxicology ................................................................................................................................................ 10

6. Adverse Reactions in Humans ........................................................................................................... 10

7. Dependence Potential .......................................................................................................................... 11

A. Animal Studies ................................................................................................................................................................. 11 B. Human Studies................................................................................................................................................................. 11

8. Abuse Potential ...................................................................................................................................... 11

A. Animal Studies ................................................................................................................................................................. 11 B. Human Studies................................................................................................................................................................. 11

9. Therapeutic Applications and Extent of Therapeutic Use and Epidemiology of Medical

Use .............................................................................................................................................................. 11

10. Listing on the WHO Model List of Essential Medicines .............................................................. 12

11. Marketing Authorizations (as a Medicinal Product) ................................................................. 12

12. Industrial Use ......................................................................................................................................... 12

13. Non-Medical Use, Abuse and Dependence ..................................................................................... 12

39th ECDD (2017) Agenda item 4.2 5F-ADB

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14. Nature and Magnitude of Public Health Problems Related to Misuse, Abuse and

Dependence ............................................................................................................................................. 12

15. Licit Production, Consumption and International Trade ......................................................... 13

16. Illicit Manufacture and Traffic and Related Information ........................................................ 13

17. Current International Controls and Their Impact ...................................................................... 13

18. Current and Past National Controls ................................................................................................ 13

19. Other Medical and Scientific Matters Relevant for a Recommendation on the Scheduling

of the Substance ..................................................................................................................................... 13

References ................................................................................................................................................ 14

Annex 1: Report on WHO Questionnaire for Review of Psychoactive Substances for the 39th ECDD: Evaluation of 5F-ADB .................................................................................................... 16

39th ECDD (2017) Agenda item 4.2 5F-ADB

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Acknowledgements

This report has been drafted under the responsibility of the WHO Secretariat, Department of

Essential Medicines and Health Products, Teams of Innovation, Access and Use and Policy,

Governance and Knowledge. The WHO Secretariat would like to thank the following people for

their contribution in producing this review report: Dr. Wim Best, Netherlands (literature review and

drafting), Ms. Dilkushi Poovendran, Geneva, Switzerland (questionnaire analysis and report

drafting) and Dr. Stephanie Kershaw, Adelaide, Australia (review report editing, questionnaire

analysis and report drafting).

39th ECDD (2017) Agenda item 4.2 5F-ADB

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Summary

5F-ADB is a synthetic cannabinoid receptor agonist (SCRA) with an aminoalkylindazole structure

used as an active ingredient of products sold as cannabis substitutes. 5F-ADB has no known

therapeutic or medical use. In different regions it is being used and abused for non-medical purposes.

Furthermore, some countries have put 5F-ADB under national control.

When smoked, 5F-ADB produces cannabimimetic effects like Δ9-tetrahydrocannabinol (THC).

Doses needed to produce these effects are lower than for THC Many of the risks linked to cannabis

use are also present in the case of 5F-ADB, among them complications in patients suffering from

cardiovascular diseases and triggering of acute psychosis.

39th ECDD (2017) Agenda item 4.2 5F-ADB

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1. Substance identification

A. International Nonproprietary Name (INN)

Not applicable

B. Chemical Abstract Service (CAS) Registry Number

1715016-75-3 (racemate)

1838134-16-9 (R-enantiomer)

C. Other Chemica