322: maternal obesity and perinatal outcomes: does the definition of obesity matter?

1
likely to receive postpartum glucose testing. Whereas, patients with pharmacotherapy for GDM were more likely to be screened. CONCLUSION: In this study, 55.1% of the patient with GDM failed to complete postpartum glucose testing. Considering the relative high prevalence of diabetes (18.4%) persisting in postpartum period in GDM in our study population, it seems urgently necessary to emphasize to patients with factors affecting noncompliance to testing about importance of postpartum glucose testing. Further- more, to encourage postpartum glucose testing in patients who had been referred from private other clinics, collaborative strategy to alert the patient for follow up testing should be implemented. 322 Maternal obesity and perinatal outcomes: does the definition of obesity matter? Jonathan Snowden 1 , Blair Darney 1 , Yvonne Cheng 2 , Nicole Marshall 1 , Elliott Main 3 , William Gilbert 4 , Judith Chung 5 , Aaron Caughey 1 1 Oregon Health & Science University, Portland, OR, 2 University of California, San Francisco, San Francisco, CA, 3 California Pacic Medical Center, San Francisco, CA, 4 Sutter Health, Sacramento, CA, 5 University of California, Irvine, Irvine, CA OBJECTIVE: Maternal obesity strongly predicts adverse perinatal outcomes, but body mass index (BMI) data are frequently unavai- lable in large databases. Prior research has used binary weight cutoffs as a proxy for obesity. We compared a common weight-based de- nition of obesity to the BMI denition, to assess misclassication and impact on effect estimates. STUDY DESIGN: This was a retrospective cohort study of all non- anomalous, singleton California deliveries in 2007, analyzing linked birth certicate and patient discharge data. We employed a common binary weight-based obesity denition (prepregnancy weight 200 lbs) and the BMI-based obesity denition (BMI 30 kg/m2). We assessed misclassication of maternal obesity using the weight-based denition. We calculated frequency of adverse perinatal outcomes between obese and non-obese women and conducted multivariable logistic regression to examine the impact of using a weight-based denition of obesity. RESULTS: A smaller proportion of women were classied as obese using the weight-based denition compared with the BMI-based denition (8.6% versus 18.8%, P<0.001). A majority of obese women (55.3%) were misclassied as non-obese using the simpler denition. This misclassication was most frequent in women of short stature and Hispanic and Asian-American women. The weight- based denition tended to exaggerate the prevalence of perinatal outcomes in obese women compared with the BMI denition (e.g., gestational hypertension, 13.6% versus 10.9%), strengthening the corresponding effect estimates (weight-based aOR: 2.93, 95% CI: 2.83 - 3.03 vs BMI-based aOR: 2.63, 95% CI: 2.55 - 2.70). This trend was attenuated for outcomes where short stature is a risk factor (e.g., low birthweight). CONCLUSION: Using a binary weight-based denition misclassies a majority of obese women. This misclassication biases estimates of perinatal outcomes among obese women. The direction and magnitude of the bias depends on the perinatal outcome being studied. Misclassification of obesity and prevalence of perinatal outcomes using a weight-based and a BMI-based definition of obesity 323 Gestational diabetes, obesity, and self perceived risk of type 2 diabetes Rabia Siddik-Ahmad 1 , Matthew Garabedian 1 , Francesca Ianovich 1 , Nisha Jadhaw 1 , Kristine Lain 2 1 Santa Clara Valley Medical Center, Department of Obstetrics and Gynecology, San Jose, CA, 2 Norton Healthcare, Kosair Childrens Hospital Maternal Fetal Medicine, Louisville, KY OBJECTIVE: To evaluate self-perceived risk of Type 2 Diabetes (T2DM) in patients with gestational diabetes (GDM). We hypoth- esized that women with GDM would perceive higher risk and be more willing to make lifestyle changes when compared to non- diabetic controls. As obesity is also a risk factor for T2DM, we also examined patient perception of risk related to obesity. STUDY DESIGN: This is a cross sectional study of postpartum women at a tertiary care center from July 1, 2012 to May 31, 2013. Women without pre-gestational diabetes and with a pre-pregnancy BMI 18.5 were eligible for inclusion. The primary outcome was self- perceived risk of T2DM. Secondary outcomes included willingness to make lifestyle changes and perception that these changes could modify risk assessed using an externally validated questionnaire. Secondary-analysis was performed to assess these outcomes in obese and non-obese, non-diabetic subjects. RESULTS: 195 patients were enrolled. Patients with GDM were more likely to report high perception of T2DM risk in the next 10 years than patients without GDM (75.0% v. 15.5%, p<0.01). However, GDM patients were not more willing to make healthier lifestyle changes (82.1% v. 76.9%, p¼0.54). Obese patients without diabetes were no more likely to report high risk of T2DM than their non- obese non-diabetic cohort (14.9% v. 14.8%, p¼0.98) and were not more willing to make healthier lifestyle changes (80.8% v. 70.6%, p¼0.18). Both GDM patients as well as non-diabetic obese patients demonstrated understanding that a history of GDM is a risk factor for T2DM, but showed inconsistent knowledge regarding modiable and non-modiable risk factors (Table). CONCLUSION: GDM patients perceive themselves at high risk of developing T2DM, but obese patients do not. Neither group was more willing to implement lifestyle changes for risk modication compared to controls. These ndings identify a need for targeted education regarding potential for risk modication by healthier lifestyle choices. Poster Session II Hypertension, Diabetes, Prematurity, Physiology www.AJOG.org S168 American Journal of Obstetrics & Gynecology Supplement to JANUARY 2014

Upload: aaron

Post on 30-Dec-2016

215 views

Category:

Documents


2 download

TRANSCRIPT

Page 1: 322: Maternal obesity and perinatal outcomes: does the definition of obesity matter?

Poster Session II Hypertension, Diabetes, Prematurity, Physiology www.AJOG.org

likely to receive postpartum glucose testing. Whereas, patients withpharmacotherapy for GDM were more likely to be screened.CONCLUSION: In this study, 55.1% of the patient with GDM failed tocomplete postpartum glucose testing. Considering the relative highprevalence of diabetes (18.4%) persisting in postpartum period inGDM in our study population, it seems urgently necessary toemphasize to patients with factors affecting noncompliance totesting about importance of postpartum glucose testing. Further-more, to encourage postpartum glucose testing in patients who hadbeen referred from private other clinics, collaborative strategy toalert the patient for follow up testing should be implemented.

322

Maternal obesity and perinatal outcomes: does thedefinition of obesity matter?Jonathan Snowden1, Blair Darney1, Yvonne Cheng2,Nicole Marshall1, Elliott Main3, William Gilbert4, Judith Chung5,Aaron Caughey11Oregon Health & Science University, Portland, OR, 2University of California,San Francisco, San Francisco, CA, 3California Pacific Medical Center, SanFrancisco, CA, 4Sutter Health, Sacramento, CA, 5University of California,Irvine, Irvine, CA

OBJECTIVE: Maternal obesity strongly predicts adverse perinataloutcomes, but body mass index (BMI) data are frequently unavai-lable in large databases. Prior research has used binary weight cutoffsas a proxy for obesity. We compared a common weight-based defi-nition of obesity to the BMI definition, to assess misclassificationand impact on effect estimates.STUDY DESIGN: This was a retrospective cohort study of all non-anomalous, singleton California deliveries in 2007, analyzing linkedbirth certificate and patient discharge data. We employed a commonbinary weight-based obesity definition (prepregnancy weight � 200lbs) and the BMI-based obesity definition (BMI � 30 kg/m2). Weassessed misclassification of maternal obesity using the weight-baseddefinition. We calculated frequency of adverse perinatal outcomesbetween obese and non-obese women and conducted multivariablelogistic regression to examine the impact of using a weight-baseddefinition of obesity.RESULTS: A smaller proportion of women were classified as obeseusing the weight-based definition compared with the BMI-baseddefinition (8.6% versus 18.8%, P<0.001). A majority of obesewomen (55.3%) were misclassified as non-obese using the simplerdefinition. This misclassification was most frequent in women ofshort stature and Hispanic and Asian-American women. The weight-based definition tended to exaggerate the prevalence of perinataloutcomes in obese women compared with the BMI definition (e.g.,gestational hypertension, 13.6% versus 10.9%), strengthening thecorresponding effect estimates (weight-based aOR: 2.93, 95% CI:2.83 - 3.03 vs BMI-based aOR: 2.63, 95% CI: 2.55 - 2.70). This trendwas attenuated for outcomes where short stature is a risk factor (e.g.,low birthweight).CONCLUSION: Using a binary weight-based definition misclassifies amajority of obese women. This misclassification biases estimates ofperinatal outcomes among obese women. The direction andmagnitude of the bias depends on the perinatal outcome beingstudied.

S168 American Journal of Obstetrics & Gynecology Supplement to JANUARY

Misclassification of obesity and prevalence ofperinatal outcomes using a weight-based and aBMI-based definition of obesity

323 Gestational diabetes, obesity, and self perceived risk of

type 2 diabetesRabia Siddik-Ahmad1, Matthew Garabedian1, Francesca Ianovich1,Nisha Jadhaw1, Kristine Lain21Santa Clara Valley Medical Center, Department of Obstetrics andGynecology, San Jose, CA, 2Norton Healthcare, Kosair Children’s HospitalMaternal Fetal Medicine, Louisville, KY

OBJECTIVE: To evaluate self-perceived risk of Type 2 Diabetes(T2DM) in patients with gestational diabetes (GDM). We hypoth-esized that women with GDM would perceive higher risk and bemore willing to make lifestyle changes when compared to non-diabetic controls. As obesity is also a risk factor for T2DM, we alsoexamined patient perception of risk related to obesity.STUDY DESIGN: This is a cross sectional study of postpartum womenat a tertiary care center from July 1, 2012 to May 31, 2013. Womenwithout pre-gestational diabetes and with a pre-pregnancy BMI �18.5 were eligible for inclusion. The primary outcome was self-perceived risk of T2DM. Secondary outcomes included willingnessto make lifestyle changes and perception that these changes couldmodify risk assessed using an externally validated questionnaire.Secondary-analysis was performed to assess these outcomes in obeseand non-obese, non-diabetic subjects.RESULTS: 195 patients were enrolled. Patients with GDM were morelikely to report high perception of T2DM risk in the next 10 yearsthan patients without GDM (75.0% v. 15.5%, p<0.01). However,GDM patients were not more willing to make healthier lifestylechanges (82.1% v. 76.9%, p¼0.54). Obese patients without diabeteswere no more likely to report high risk of T2DM than their non-obese non-diabetic cohort (14.9% v. 14.8%, p¼0.98) and were notmore willing to make healthier lifestyle changes (80.8% v. 70.6%,p¼0.18). Both GDM patients as well as non-diabetic obese patientsdemonstrated understanding that a history of GDM is a risk factorfor T2DM, but showed inconsistent knowledge regarding modifiableand non-modifiable risk factors (Table).CONCLUSION: GDM patients perceive themselves at high risk ofdeveloping T2DM, but obese patients do not. Neither group wasmore willing to implement lifestyle changes for risk modificationcompared to controls. These findings identify a need for targetededucation regarding potential for risk modification by healthierlifestyle choices.

2014