2014 Faculty Senate Awards Mission College of Pharmacy Research Award

Nominee Name: Arup Indra Email: indra@ohsu.edu Phone: 8-4273 Department: SM.Dermatology Admin – College of Pharmacy Joint Appointment

Nomination Submissions and Required Documents Included in Packet 1. Nomination Letters – 2

a. David Lee b. David Bearden

2. Summary 3. CV 4. Letter of Support - 2

a. External - Zalfa Abdel-Malek, University of Cincinnati b. External – Andrzej Slominski, University of Tennessee

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Tangible evidence that the individual selection committee may weigh in to make their decisions are : A. Positions and Employment at OHSU (besides current position in College of Pharmacy) 2011-present Full member, Solid Tumor Program, Knight Cancer Institute, OHSU

2011-present Associate Professor (Adjunct), Department of Dermatology, OHSU B. Recipient of two investigator generated NIH R01 grants. 1. R01 AR056008 7/1/08-6/30/13 NIH (NIAMS)

Mechanism of CTIP2 action in mouse epidermal homeostasis and barrier formation, and in human HNSCC The major goals of this project are to define the molecular basis for the action of CTIP2 in physiological and pathological skin using our conditionally ablated mouse model. Role in the project : PI

2. R01 ES016629-01 12/1/08- 30/11/13 NIH (NIEHS) Mechanism of keratinocyte RXRa mediated melanoma skin cancer development The major goals of this project are (1) to elucidate the cellular and molecular mechanisms

by which skin keratinocytes control melanoma formation, and (2) to identify intracellular y y-induced

melanomagenesis. Role in the project : PI

C. Recipient of two additional grants from private foundations. 1. OSU Venture Fund 12/1/09-11/30/10 Private Grant “CTIP2 is a potential molecular marker to stage Head and Neck cancer and cancers of

the epithelial cells.” Role in the project : co-PI 2. ONAMI 1/1/11-12/31/12 Private Grant “Early detection of cancer with carbon nanotube biosensors” The major goals of this project

are (1) to develop carbon nano-tube based biosensors for early detection of cancers such as head and neck cancers.

Role in the project : co-PI D. Recipient of US patent for the discovery of a new biomarker for Head and Neck

Cancer. Indra G. (inventor), Indra A. K., Abecassis J and Leid M were issued a United States Patent,

US 8,071,815 B2. Dec.6, 2011. Ctip2 expression in Squamous Cell Carcinoma

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E. Eleven publications as a corresponding or co-corresponding author in several

high impact journals in the last 5 years. 1. Ganguli-Indra G, Wasylyk C, Liang X, Millon R , Leid M, Wasylyk B, Abecassis J and Indra

AK. (2009). CTIP2 expression in human Head and Neck squamous cell carcinoma is linked to poorly differentiated tumor status. PLoS One;4(4):e5367. Epub 2009 Apr 28. PMCID: PMC2671404.

2. Indra, G. #, Hyter, S., Liang, X. Hanifin, J and Indra, A.K. (2009) Expression of Chicken ovalbumin upstream promoter transcription factor (COUP-TF)-interacting protein 2 (CTIP2) in human inflammatory skin diseases. Experimental Dermatol. Mar 29: 1-3. PMCID: PMC2783464.

3.Hyter, S., Bajaj, G., Liang, X, Barbacid, M., Indra G., Indra, A.K. (2010). Loss of nuclear receptor RXRα in epidermal keratinocytes promotes the formation of Cdk4-activated invasive melanomas. Pigment Cell and Melanoma Research. Oct : 23 (5) : 635-648. PMCID: PMC2939934

4.Wang Z., Coleman, D.J., Bajaj, G., Liang X., Ganguli-Indra, G., Indra, A.K. (2011). ablation in epidermal keratinocytes enhances UV radiation induced DNA damage, apoptosis, and proliferation of keratinocytes and melanocytes. JID (NPG). Jan;131(1):177-87. Epub 2010 Oct 14. PMCID:PMC3073005

5. Liang X, Bhattacharya S, Bajaj G, Guha G, Wang Z, Jang HS, Leid M, Indra AK*, Ganguli-Indra G*. Delayed cutaneous wound healing and aberrant expression of hair follicle stem cell markers in mice selectively lacking ctip2 in epidermis. PLoS One. 2012;7(2):e29999. Epub 2012 Feb 21.PMCID: PMC3283611.

6. Wang Z., Zhang L., Guha G., Li S., Krylkova K., Kioussi C., Leid M., Ganguli-Indra G., Indra A.K. (2012). Selective Ablation of Ctip2/Bcl11b in Epidermal Keratinocytes Triggers Atopic Dermatitis-like Skin Inflammatory Responses in Adult Mice. PLoS One 2012;7(12):e51262. doi: 10.1371/ journal.pone. 0051262. PMCID: PMC3527437.

7. Zhang LJ, Bhattacharya S, Leid M, Ganguli-Indra G, Indra AK. (2012). Ctip2 is a dynamic regulator of epidermal proliferation and differentiation by integrating EGFR and Notch signaling. J Cell Sci. 2012 Sep 26.

8. Hyters S., Coleman D., Ganguli-Indra G., Merril G.F., Ma S., Yanagisawa M., Indra A.K.(2012) Endothelin-1 is a transcriptional target of p53 in epidermal keratinocytes and regulates UV induced melanocyte homeostasis. PCMR Dec 29. doi: 10.1111/pcmr.12063.

9. Hyter, S and Indra AK. (2013) Nuclear hormone receptor functions in keratinocyte and melanocyte homeostasis, epidermal carcinogenesis and melanomagenesis FEBS Letter Mar 18;587(6):529-41. doi: 10.1016/j.febslet.2013.01.041.

10. Indra AK. (2013) Epidermal TSLP: a trigger factor for pathogenesis of atopic dermatitis. Expert Rev Proteomics. Aug;10(4):309-11. doi: 10.1586/14789450.2013.814881.

11. Venkataraman A, Coleman DJ, Nevrivy DJ, Long T, Kioussi C, Indra AK*, Leid M*. Grp1-associated scaffold protein regulates skin homeostasis after ultraviolet irradiation. Photochem Photobiol Sci. 2014 Jan 9.

*co-corresponding author

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F. Involved in at least four collaborative research projects with different faculties in the Dept. of Dermatology and in the Dept. of Cell and Developmental Biology, OHSU one of which resulted in peer reviewed publication.

Indra, G. #, Hyter, S., Liang, X. Hanifin, J and Indra, A.K. (2009) Expression of Chicken

ovalbumin upstream promoter transcription factor (COUP-TF)-interacting protein 2 (CTIP2) in human inflammatory skin diseases. Experimental Dermatol. Mar 29: 1-3. PMCID: PMC2783464.

Guha, G. , Lu,W., Kulesz-Martin, M., Mahmud, T., Indra, A.K. and Ganguli-Indra, G. Novel pactamycin analogs induces S phase arrest and subsequent loss of G2 phase cells in human head and neck squamous cell carcinoma (HNSCC) cells. (In prep, PloS ONE).

G. Past and Present collaborators at OHSU Jon Hanifin, MD

Eric Simpson, MD

Molly Kulesz-Martin, Ph.D

Sancy Leachman, MD, Ph.D

H. Indra Lab was highlighted on several occasions at the University level, National and International level including once by the NIH director’s office and by the National eczema Association (three selected evidences are provided below)

1. Indra Lab’s work was highlighted in the University New Release from the division of News

and Research Communication entitled “Researchers discover genetic basis for eczema, new avenue to therapies” on Dec 21, 2012.

http://oregonstate.edu/ua/ncs/archives/2012/dec/researchers-discover-genetic-basis-eczema-new-avenue-therapies

2. Indra Lab’s work was highlighted on the the weekly edition of NIH Research matters from the NIH Director’s office and the story is posted at http://www.nih.gov/researchmatters/january2013/01142013atopic.htm.

3. Indra Lab’s work was highlighted on the communication channel of the National Eczema Association (NEA), entitled “Treating Chronic Skin Disease-Mouse model mimics human eczema”. Feb, 2013.

I. Awards and Honors 1. Recipient of People’s Choice Award People's Choice Award in the 2009 Austin Enterprise

Challenge competition jointly with Gitali Ganguli-Indra and Mark Leid for help in developing a business plan “NeoHope” together with the MBA Masters students.

2. Recipient of Faculty Internationalization Grant in May 2013 for promoting global learning and fostering strategic international partnerships to promote faculty research and outreach activities.

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3. Drs. Arup and Gitali Indra have been chosen to be recognized as OnPoint Faculty on Nov1, 2013 by Oregon State Faculty Senate (together with OnPoint Community Credit Union) for their outstanding achievements in teaching, research and leadership.

J. Graduate students from Indra Lab have competed with other students from OHSU to receive awards at the Students Research Forum meeting, OHSU in three consecutive years in the last 5 years.

Dan Coleman, First place, Outstanding Student Award Oregon Health and Science University, May 2012 Stephen Hyter, First place, Outstanding Student Award Oregon Health and Science University, May 2011 Dan Coleman, Second place, Pathology section Oregon Health and Science University, May 2010

K. Accepted in the graduate school at OHSU and serving on the graduate study committee for students in the Dept. of Dermatology, OHSU. Aaron M. Wortham, Ph.D. Candidate, Cancer Biology Program

L. Graduate students from Indra Lab has been awarded with NCI Training Grants in a row for 4 years from the Dept. of Dermatology, OHSU on a collaborative basis. Recipients are : Stephen Hyter : 1 year (2010-2011) Dan Coleman : 2 years (2011-2012 : 2012-2013) Gloria Garcia : 1 year (2013-2014)

M. Invited seminars and accepted abstracts for podium presentation in reputed National and International Conferences (selective 8 out of 15 in the last 5 years). 1. Nuclear Receptor Signaling in tumor micro-environment during melanoma formation.

November 27- 29, 2008. International Symposium on “Perspective of Cell Signaling and Molecular Medicine” at Bose Institute, Kolkata , India.

2. Invited Hot Topic Speaker at the Gordon Conference on Barrier Function of Mammalian Skin held, August 9-14, 2009 at Waterville Valley Resort Waterville Valley, NH, on “Dual role of COUP-TF-interacting protein 2 (CTIP2) in epidermal homeostasis and permeability barrier formation”.

3. Presented a seminar entitled “Novel role of Chicken ovalbumin upstream promoter transcription factor (COUP-TF)-interacting proteins 2 (CTIP2) in skin during

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development” as Speaker at the 58th annual Montagna Symposium on the Biology of the Skin held October 8-12, 2009 at Salishan Spa & Golf Resort in Gleneden Beach on the Oregon coast.

4. Presented a seminar entitled “during melanoma progression” at the 9th International Skin Cancer Conference (Penn State University) June 24-28, 2010.

5. Presented a plenary lecture entitled “Nuclear receptor mediated paracrine signaling in tumor microenvironment during melanomagenesis” at the Pigmentation & Melanoma Research Conference September 30 – October 2, 2010, BC Cancer Research Centre, Vancouver, BC.

6. Delivered a plenary lecture in the “Melanoma Biology” session of 21st International Pigment Cell Conference held in Bordeaux, France from Sept, 21-24, 2011.

7. Delivered a plenary lecture in the “Keratins as Determinant of Health and Disease” session of 60th Montagna Symposia on the biology of the Skin held in Washington, USA from Oct , 13-17, 2011.

8. Presented a seminar entitled “Retinoid-X-Receptors (ɑ/ ) in melanocytes modulate innate immune responses and differentially regulate cell survival following UV irradiation” as Speaker in the Pigmentation and Photobiology session at the 62nd Montagna Symposium on the Biology of the Skin held October 10-14, 2013 at Skamania Lodge, Stevenson, Washington, USA.

N. Leadership and International Service : 1. Travelled to two top Institutes in India including Indian Institute of Science, Bangaluru and

Dept. of Biochemistry and Biotechnology, Kolkata University as a visiting scientist in June, 2013. Gave guest lectures to graduate level students pursuing MS or PhD degree.

2. Met and discussed with Dean (Science) and Pro-Vice Chancellor of Kolkata University regarding possible faculty exchange and student exchange program and develop Indo-US collaborative program, June 2013.

3. Met with the Head of the Dept. of Microbiology and Cell in Indian Institute of Science, Bangaluru related to study abroad and international collaboration, June 2013.

David Lee leedavid@ohsu.edu

Faculty Senate Awards Dr. Indra’s contributions within his discipline are substantive and important. His manuscripts have been published in Pigment Cell and Melanoma Research and the Journal of Investigative Dermatology. Having mentored several junior faculty members at my institution, I can attest to the achievements of Dr. Indra within a short time period. With two funded R01 grants, and 24 peer reviewed publications in reputed journals, he has become a known figure in eczema and melanoma research. I am impressed with Arup’s intellect, enthusiasm and ability to conduct difficult projects that are relevant to inflammatory skin disease (e.g. Atopic Dermatitis) and melanoma skin cancer. He is an excellent mentor, and has mentored several graduate students and postdoctoral fellows. Appointments in other Colleges, Departments or Centers: Member, Molecular & Cell Biology Program Member, Environmental Health Science Center Adjunct Faculty, Dept. of Biochemistry & Biophysics Adjunct Associate, Dept. of Dermatology, OHSU Full member, Knight Cancer Institute Recognition last year Indra A.K. has been appointed to the editorial board of International Journal of Bioorganic Chemistry & Molecular Biology (IJBCMB). Indra A.K. has been appointed to the editorial board of RECEPTORS & CLINICAL INVESTIGATION. Joint delegate of College of Pharmacy together with Gitali Indra in the “India Inititative” program. Indra A.K. and Indra G. met and discussed with pro-vice Chancellor of Calcutta University (CU) for a possible MOU between CU and OSU. Professional recognition of research 1. Indra Lab’s work was highlighted in the Science News Blog at http://www.sciencedaily.com/releases/2012/12/121221131259.htm. entitled “Researchers discover genetic basis for eczema, new of News and Research Communication on ” on Dec 21, 2012. 2. Indra Lab’s work was highlighted on the editorial column of the Dermatologists blog (http://www.dermatologistsblog.com), Jan, 2013 related to thir recent publication recent important publication: “Selective Ablation of Ctip2/Bcl11b in Epidermal Keratinocytes Triggers Atopic Dermatitis-Like Skin Inflammatory Responses in Adult Mice”.

3. Indra Lab’s work was highlighted on the editorial column of the Dermatologists blog (http://www.dermatologistsblog.com), Jan, 2013 related to thir recent publication recent important publication: “Selective Ablation of Ctip2/Bcl11b in Epidermal Keratinocytes Triggers Atopic Dermatitis-Like Skin Inflammatory Responses in Adult Mice”.

Faculty Senate Awards 4. Indra Lab’s work was highlighted on the the weekly edition of NIH Research matters from the NIH Director’s office and the story is posted at http://www.nih.gov/researchmatters/january2013/01142013atopic.htm. 5. Indra Lab’s work was highlighted on the communication channel of the National Eczema Association (NEA), entitled “Treating Chronic Skin Disease-Mouse model mimics human eczema”. Feb, 2013. 6. A pubcast highlighting recent publication entitled “Endothelin-1 is a transcriptional target of p53 in epidermal keratinocytes and regulates UV induced melanocyte homeostasis” in PCMR was released by Willey Blackwell Inc. through Scivee (http://www.scivee.tv/node/56891) on Feb 13, 2013. 7. Indra Lab’s work was highlighted in the University New Release from the division of News and Research Communication entitled “Researchers discover genetic basis for eczema, new avenue to therapies” on Dec 21, 2012. http://oregonstate.edu/ua/ncs/archives/2012/dec/researchers-discover-genetic-basis-eczema-new-avenue-therapies 8. Indra Lab’s work was highlighted in the Terrabytes story, winter 2013 issue of Terra Magazine Working title: “Treating Chronic Skin Disease-Mouse model mimics human eczema”. 9. Indra Lab’s work was highlighted on the "Next" column of the Oregon Business Magazine, which provides snapshots of research at Oregon Universities, March 2013.

David Bearden beardend@ohsu.edu

Summary of accomplishments We are investigating the mechanisms underlying skin development in space and time from stem cells. We discovered a key protein necessary for healthy skin formation in collaboration with Drs. Gitali Ganguli-Indra and Mark Leid. We identified key factors that are essential to maintain a balance in skin, lack of which can lead to childhood mortality or can trigger onset of inflammatory skin diseases e.g. Atopic dermatitis. A lipidomics approach for profiling skin lipids to predict disease progression in Atopic Dermatitis patients are currently underway in collaboration with faculties at OHSU and OSU. We are also studying the cell-cell signaling that are functional within the tumor-microenvironment and contributing to cancer metastasis. We discovered that nuclear receptor (NR) signaling between skin keratinocytes & melanocytes can contribute to formation of malignant melanomas. The crosstalk of NR signaling with other signaling pathways and their role in mediating metastasis are being investigated. We have developed multiple pre-clinical models of human diseases and are utilizing them to screen for natural compounds as new drug leads for effective therapeutic intervention. In collaboration, we have a patented biomarker for head and neck cancer progression. All researches were funded by two R01 grants from NIH with me as PI.

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BIOGRAPHICAL SKETCH Provide the following information for the key personnel and other significant contributors in the order listed on Form Page 2.

Follow this format for each person. DO NOT EXCEED FOUR PAGES.

NAME Arup Indra

POSITION TITLE Associate Professor of Pharmacology, OSU-OHSU Associate Professor of Dermatology (Adjunct), OHSU

eRA COMMONS USER NAME (credential, e.g., agency login) AINDRA EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.)

INSTITUTION AND LOCATION DEGREE (if applicable) MM/YY FIELD OF STUDY

Calcutta University, INDIA B. Sc. 03/1988 Chemistry Calcutta University, INDIA M.Sc. 03/1990 Bio-chemistry Calcutta University, INDIA Ph.D. 06/2001 Molecular Biology

IGBMC, France Post Doc 01/1997-2002

Molecular & Cell Biology

IGBMC, France Post Doc 01/2002-2005

Cancer Biology

A. Positions and Honors Positions and Employment 1991 – 1997 Graduate student under Dr. Prabhakar Gupta & Prof. R. K. Mandal, Bose Institute, India. 2001 Ph.D degree awarded (Jadavpur University, India) 1997 – 2002 Postdoctoral Fellow under Professeur Pierre Chambon, Institut de Génétique et de Biologie

Moléculaire et Cellulaire, Université Louis Pasteur, Illkirch, FRANCE 2002 – 2005 Research Scientist under Professeur Pierre Chambon , Institut de Génétique et de Biologie

Moléculaire et Cellulaire, Université Louis Pasteur, Illkirch, FRANCE 2005–present Assistant Professor of Pharmacology, College of Pharmacy, Oregon State University 2005–present Faculty member, Graduate Program in Molecular and Cellular Biology, Oregon State University 2006-present Faculty member, Environmental Health Science Center, Oregon State University 2007-present NIEHS training grant faculty 2010-2011 Assistant Professor (Adjunct), Department of Dermatology, OHSU, Portland, OR 2011-present Full member, Solid Tumor Program, Knight Cancer Institute, OHSU 2011-present Associate Professor of Pharmacology, College of Pharmacy, OSU 2011-present Associate Professor (Adjunct), Department of Dermatology, OHSU, Portland, OR Other Experience and Professional Memberships 2005-present AACR active member 2005-present American Association of College of Pharmacy (AACP) member 2005-present Pan American Society of Pigment Cell Research (PASPCR) member 2006-present Rho Chi Society Member 2006-present Member of European Society of Investigative Dermatology 2009-present Member of Society of Investigative Dermatology 2009-present Ad hoc reviewer, National Institute of Health (NIAMS) 2009 Ad hoc reviewer, NIH Challenge Grant (NIH/CSR) [2009] 2009-present Ad hoc reviewer, Wellcome Trust Grant (UK) 2010 Ad hoc reviewer, DOD, Congressionally Directed Medical Research Programs (CDMRP)

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2010-present Adhoc reviewer for Research Grants from French National Research Agency (ANR) 2010-present Ad hoc reviewer, DOD, Congressionally Directed Medical Research Programs (CDMRP) 2010-present Co-chair, Molecular & Cellular Biology Program, Graduate Admission Committee 2009-present Ad hoc reviewer, PCMR, JMB, Journal of Investigative Dermatology, Endocrinology 2012-present Ad hoc reviewer, Development, Experimental Dermatology, PloS One, Cancer Letters, Nature

Genetics Honors 1994 Young Scientist Award at the 16th International Congress of Biochemistry & Molecular Biology,

New Delhi, 1994. 1997–2002 Université Louis Pasteur Postdoctoral Fellowship. France. 1999–2001 Human Frontier Science Program project fellowship, France. 2003 Aida Weiss Award in Oncology Research, Mexico. 2004 American Association for Cancer Research (AACR) Scholar-in-Training Award. 2009 People's Choice Award in the 2009 Austin Enterprise Challenge competition jointly with Gitali

Ganguli-Indra and Mark Leid for help in developing a business plan “NeoHope” together with the MBA Masters students.

2013 Recipient of Faculty Internationalization Award in May 2013 for promoting global learning and fostering strategic international partnerships to promote faculty research and outreach

activities. Patents Indra G. (inventor), Indra A. K. (co-inventor), Abecassis J and Leid M Ctip2 expression in

Squamous Cell Carcinoma. # US 8,071,815 B2. Dec.6, 2011

B. Peer-Reviewed Publications 11 out of total 25 in the past 5 years (in chronological order) 1. Ganguli-Indra G, Wasylyk C, Liang X, Millon R , Leid M, Wasylyk B, Abecassis J and Indra AK. (2009).

CTIP2 expression in human Head and Neck squamous cell carcinoma is linked to poorly differentiated tumor status. PLoS One;4(4):e5367. Epub 2009 Apr 28. PMCID: PMC2671404.

2. Indra, G. *, Hyter, S., Liang, X. Hanifin, J and Indra, A.K. (2009) Expression of Chicken ovalbumin upstream promoter transcription factor (COUP-TF)-interacting protein 2 (CTIP2) in human inflammatory skin diseases. Experimental Dermatol. Mar 29: 1-3. PMCID: PMC2783464.

3. Hyter, S., Bajaj, G., Liang, X, Barbacid, M., Indra G., Indra, A.K. (2010). Loss of nuclear receptor RXRα in epidermal keratinocytes promotes the formation of Cdk4-activated invasive melanomas. Pigment Cell and Melanoma Research. Oct : 23 (5) : 635-648. PMCID: PMC2939934

4. Wang Z., Coleman, D.J., Bajaj, G., Liang X., Ganguli-Indra, G., Indra, A.K. (2011). RXRα ablation in epidermal keratinocytes enhances UV radiation induced DNA damage, apoptosis, and proliferation of keratinocytes and melanocytes. JID (NPG). Jan;131(1):177-87. Epub 2010 Oct 14. PMCID:PMC3073005

5. Liang X, Bhattacharya S, Bajaj G, Guha G, Wang Z, Jang HS, Leid M, Indra AK*, Ganguli-Indra G*. Delayed cutaneous wound healing and aberrant expression of hair follicle stem cell markers in mice selectively lacking ctip2 in epidermis. PLoS One. 2012;7(2):e29999. Epub 2012 Feb 21.PMCID: PMC3283611.

6. Wang Z., Zhang L., Guha G., Li S., Krylkova K., Kioussi C., Leid M., Ganguli-Indra G., Indra A.K. (2012). Selective Ablation of Ctip2/Bcl11b in Epidermal Keratinocytes Triggers Atopic Dermatitis-like Skin Inflammatory Responses in Adult Mice. PLoS One 2012;7(12):e51262. doi: 10.1371/ journal.pone. 0051262. PMCID: PMC3527437.

7. Zhang LJ, Bhattacharya S, Leid M, Ganguli-Indra G, Indra AK. (2012). Ctip2 is a dynamic regulator of epidermal proliferation and differentiation by integrating EGFR and Notch signaling. J Cell Sci. 2012 Sep 26.

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8. Hyters S., Coleman D., Ganguli-Indra G., Merril G.F., Ma S., Yanagisawa M., Indra A.K.(2012) Endothelin-1 is a transcriptional target of p53 in epidermal keratinocytes and regulates UV induced melanocyte homeostasis. PCMR Dec 29. doi: 10.1111/pcmr.12063.

9. Hyter, S and Indra AK. (2013) Nuclear hormone receptor functions in keratinocyte and melanocyte homeostasis, epidermal carcinogenesis and melanomagenesis FEBS Letter Mar 18;587(6):529-41. doi: 10.1016/j.febslet.2013.01.041.

10. Indra AK. (2013) Epidermal TSLP: a trigger factor for pathogenesis of atopic dermatitis. Expert Rev Proteomics. Aug;10(4):309-11. doi: 10.1586/14789450.2013.814881.

11. Venkataraman A, Coleman DJ, Nevrivy DJ, Long T, Kioussi C, Indra AK*, Leid M*. Grp1-associated scaffold protein regulates skin homeostasis after ultraviolet irradiation. Photochem Photobiol Sci. 2014 Jan 9.

*co-corresponding author C. Invited seminars and accepted abstracts for podium presentation in reputed National and

International Conferences (selective 8 out of 15 in the last 5 years). 1. Nuclear Receptor Signaling in tumor micro-environment during melanoma formation. November 27- 29,

2008. International Symposium on “Perspective of Cell Signaling and Molecular Medicine” at Bose Institute, Kolkata , India.

2. Invited Hot Topic Speaker at the Gordon Conference on Barrier Function of Mammalian Skin held, August 9-14, 2009 at Waterville Valley Resort Waterville Valley, NH, on “Dual role of COUP-TF-interacting protein 2 (CTIP2) in epidermal homeostasis and permeability barrier formation”.

3. Presented a seminar entitled “Novel role of Chicken ovalbumin upstream promoter transcription factor (COUP-TF)-interacting proteins 2 (CTIP2) in skin during development” as Speaker at the 58th annual Montagna Symposium on the Biology of the Skin held October 8-12, 2009 at Salishan Spa & Golf Resort in Gleneden Beach on the Oregon coast.

4. Presented a seminar entitled “RXRα mediated signaling in skin tumor microenvironment during melanoma progression” at the 9th International Skin Cancer Conference (Penn State University) June 24-28, 2010.

5. Presented a plenary lecture entitled “Nuclear receptor mediated paracrine signaling in tumor microenvironment during melanomagenesis” at the Pigmentation & Melanoma Research Conference September 30 – October 2, 2010, BC Cancer Research Centre, Vancouver, BC.

6. Delivered a plenary lecture in the “Melanoma Biology” session of 21st International Pigment Cell Conference held in Bordeaux, France from Sept, 21-24, 2011.

7. Delivered a plenary lecture in the “Keratins as Determinant of Health and Disease” session of 60th Montagna Symposia on the biology of the Skin held in Washington, USA from Oct , 13-17, 2011.

8. Presented a seminar entitled “Retinoid-X-Receptors (ɑ/b) in melanocytes modulate innate immune responses and differentially regulate cell survival following UV irradiation” as Speaker in the Pigmentation and Photobiology session at the 62nd Montagna Symposium on the Biology of the Skin held October 10-14, 2013 at Skamania Lodge, Stevenson, Washington, USA.

D. Graduate students from Indra Lab have received awards at the Students Research Forum meeting,

OHSU in three consecutive years in the past 5 years. 1. Dan Coleman, Second place, Pathology section, OHSU, May 2010. 2. Stephen Hyter, First place, Outstanding Student Award, OHSU, May 2011 3. Dan Coleman, First place, Outstanding Student Award, OHSU, May 2012

E. Research Support Ongoing Research Support 1. Division of health science Interdisciplinary grant 2013-2014 (PI) 1/7/13-6/30/14 Oregon State University Grant Development and characterization of biomarkers for canine and human bladder cancer. Overall goal: of this grant proposal is to develop a new panel of biomarkers that could be used to

screen and monitor the disease progression of canine bladder cancers. Role: Co- investigator

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Completed Research Support 1. R01 AR056008 (A. Indra, PI) 7/1/08-6/30/13 NIH (NIAMS)

Mechanism of CTIP2 action in mouse epidermal homeostasis and barrier formation, and in human HNSCC The overall goals of this project are to define the molecular basis for the action of CTIP2 in physiological and pathological skin using our conditionally ablated mouse model. Role: PI

2. R01 ES016629-01 (A. Indra, PI) 12/1/08- 30/11/13 NIH (NIEHS) Mechanism of keratinocyte RXRα mediated melanoma skin cancer development

The overall goals of this project are (1) to elucidate the cellular and molecular mechanisms by which skin keratinocytes control melanoma formation, and (2) to identify intracellular signaling pathway(s) that control melanocyte homeostasis and UV-induced melanomagenesis. Role: PI

3. ONAMI (E. Minot, PI) 1/1/11-12/31/12 Private Grant “Early detection of cancer with carbon nanotube biosensors” The overall goals of this project are (1) to develop carbon nano-tube based biosensors for early detection

of cancers such as head and neck cancers. Role: PI 4. OSU Venture Fund (G. Ganguli-Indra, PI) 12/1/09-11/30/10 Private Grant ” CTIP2 is a potential molecular marker to stage Head and Neck cancer and cancers of the epithelial cells Role: PI F. Four ongoing collaborative research projects in the Dept. of Dermatology and in the Dept. of Cell

and Developmental Biology, OHSU one of which resulted in peer reviewed publication. Indra, G. #, Hyter, S., Liang, X. Hanifin, J and Indra, A.K. (2009) Expression of Chicken ovalbumin upstream promoter transcription factor (COUP-TF)-interacting protein 2 (CTIP2) in human inflammatory skin diseases. Experimental Dermatol. Mar 29: 1-3. PMCID: PMC2783464. Guha, G. , Lu,W., Kulesz-Martin, M., Mahmud, T., Indra, A.K. and Ganguli-Indra, G. Novel pactamycin analogs induces S phase arrest and subsequent loss of G2 phase cells in human head and neck squamous cell carcinoma (HNSCC) cells. (In prep,PloS ONE).

G. Indra Lab highlighted on several occasions at the University level, National and International levels (three selected evidences in the past 5 years)

1. Indra Lab was highlighted in the University New Release from the division of News and Research Communication entitled “Researchers discover genetic basis for eczema, new avenue to therapies” on Dec 21, 2012.

http://oregonstate.edu/ua/ncs/archives/2012/dec/researchers-discover-genetic-basis-eczema-new-avenue-therapies

2. Indra Lab’s work was highlighted on the weekly edition of NIH Research matters from the NIH Director’s office and the story is posted at http://www.nih.gov/researchmatters/january2013/01142013atopic.htm.

3. Indra Lab’s work was highlighted on the communication channel of the National Eczema Association (NEA), entitled “Treating Chronic Skin Disease-Mouse model mimics human eczema”. Feb, 2013.

H. Leadership and International Service (In the past 5 years): 1. Travelled to two top Institutes in India including Indian Institute of Science, Bangaluru and Dept. of

Biochemistry and Biotechnology, Kolkata University as a visiting scientist in June, 2013. Gave guest lectures to graduate level students pursuing MS or PhD degree.

2. Met and discussed with the Dean (Science) and Pro-Vice Chancellor of Kolkata University regarding faculty and student exchange program and develop Indo-US collaborative program, June 2013.

3. Met with the Head of the Dept. of Microbiology and Cell in Indian Institute of Science, Bangaluru, INDIA related to study abroad and international collaboration, June 2013.

THE UNIVERSITY OF TENNESSEE Health Science Center

Andrzej Slominski, MD, PhD College of Medicine Professor of Pathology and Medicine Department of Pathology & Laboratory Medicine

Director, Dermatopathology Training Program 930 Madison Avenue, Suite 599, Memphis, TN 38163 Tel: (901) 448-3741 • Fax: (901) 448-6979• E-mail: aslominski@uthsc.edu

Director of the Skin Cancer Division of the UT Center for Cancer ResearchSecretary of the International Federation of Pigment Cell SocietiesMember of the Editorial Board of: Experimental Dermatology, Journal of Pineal Research, Dermato-endocrinology, PLOS One, Polish Annals of Medicine

To, March 5, 2014The ChairFaculty Senate Award Nomination CommitteeOregon Health & Science University

Re: Letter of support for 2014 Faculty Senate Award Nominee

Dear committee members,

I am delighted to write a letter of support for Dr. Arup Indra, who has been nominated for the prestigious Oregon Health & Science (OHSU) Faculty Senate Award this year.

I believe that Arup is one of the most deserving of the 2014 OHSU Faculty Senate Award as a rising star scholar, educator and researcher in the field of skin biology. Moreover, I believe that Arup is an outstanding scientist in the field of skin inflammation and melanoma research that I have currently known in the nation so far. Arup is truly exceptional and I describe below the many professional and personal qualities that make Arup one of the most deserving of the 2014 Faculty Senate Award.

In the last one decade, Arup has displayed superb creativity and has made outstanding contributionstoward developing novel mouse models of inflammatory skin disease such as atopic dermatitis (AD) and melanoma skin cancer, which can be used for the identification and in vivo validation of new therapeutics for disease prevention.

Research from his group published in the prestigious Journal of Investigative Dermatology and Pigment Cell and Melanoma Research have demonstrated that skin keratinocytes can control melanocytes (pigment producing cells in the body) proliferation and melanoma formation in vivo. His work is also significant since patients with polymorphisms in the gene for RXR and VDR is expected to be at increased risk of developing melanoma, the deadliest for of the skin cancer. This seminal work from his group has been funded by a NIH R01 grant with Arup as the lead PI.

Besides, his work on the function of regulatory protein CTIP2 in mediation promotion and progression of atopic dermatitis type skin inflammatory disease, has provided extremely valuable information for the prevention and possibly cure of this very common skin disease affecting 10- 20 percent of the general population in US. This work was recently published in another reputed scientific journal PloS ONE andwas highlighted in the weekly edition of NIH Research matters from the NIH Director’s office. Indra Lab’s work was also highlighted on the communication channel of the National Eczema Association (NEA). All of his scientific endeavors have tremendously moved forward the field of micro-environmental effects on the pathogenesis of inflammatory skin diseases and melanoma skin cancer.This work on the role of the CTIP2 signaling pathways in epidermal homeostasis, barrier formation and in epithelial cancer has also been supported by another R01 grant with Arup as the lead PI.

In recognition to his contribution in Science, Arup has received many awards such as Young Scientist Award at the 16th International Congress of Biochemistry & Molecular Biology, New Delhi, INDIA; Aida Weiss Award in Oncology Research, Mexico, and American Association for Cancer Research (AACR)

THE UNIVERSITY OF TENNESSEE Health Science Center

Andrzej Slominski, MD, PhD College of Medicine Professor of Pathology and Medicine Department of Pathology & Laboratory Medicine

Director, Dermatopathology Training Program 930 Madison Avenue, Suite 599, Memphis, TN 38163 Tel: (901) 448-3741 • Fax: (901) 448-6979• E-mail: aslominski@uthsc.edu

Scholar-in-Training Award (USA). He has published several original research papers in reputed international journals such as Nature, Developmental Biology, Development, Journal of Cell Sciences, PloS ONE and Journal of Investigative Dermatology that are top ranked journals in biological science.

Arup is a dedicated scientist and a superb person to work with. He is amicable, well-mannered and has a very pleasing personality, which is liked and appreciated by all of his friends, colleagues and peers in the field. He possesses great interpersonal skin and excellent communication skill.

I think that Arup is a well deserving candidate for the 2014 OHSU Faculty Senate and I urge you to give his nomination your most serious consideration. Please do not hesitate to contact me if you have any questions or if you need clarification of my role as a peer to assess and judge Arup’s capacity for scientific research and pedagogy for science education.

Yours Sincerely

Andrzej Slominski, MD, PhDProfessor of Pathology and Medicine