#11 Anemii Yanev DM 2013

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#11 Anemii Yanev DM 2013

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  • . . , , ,

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  • (7 - 8 ; 5.1012/L). , ( ). ~ 120 .

  • 5.2 0.3.1012/L 4.7 0.3.1012/L - 160 20 g/L 140 20 g/L 0,40 0,54 0,36 0,47

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  • Hb , Ers , Hct

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  • : Adisson Biermer ( ) ( )

  • HLA-A3, HLA-B7 : 12

    - Addison-Biermer

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  • Er (M. Minkowski-Chauffard)

  • Ers-6- - - - -

  • Icterus gravis Rh Rh- Rh+ 1 2

  • Rh -

  • - (-thalassemia mayor) - (-thalassemia minor) - -

  • Thalassemia mayor (M. Cooley) HbF HbA2 - - - Ers

  • OXY-DEOXY- - , S

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    II

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    ( VIII) B ( IX) C ( XI)

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  • Thrs ( 150-450109/L) Thrs 150109/L.

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  • * O2 CO2.RBC contain a large quantity of carbonic anhydrase: a large amount of CO2 is transported from the tissues to the lungs under the form of bicarbonate.

    *Deoxygenation of SS erythrocytes leads to intracellular hemoglobin polymerization, loss of deformability and changes in cell morphology.