10 min

1 s

Anesthesia

!"##

Water delivery port

Micropipette

Electrode holder

Head bar clamps

Odor tube

a b

c

Awake

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

GCL EPLGCL

Broadly tuned and respiration-independent inhibition in the olfactory bulb of awake miceBrittany N. Cazakoff, Billy Y. B. Lau, Kerensa L. Crump, Heike S. Demmer and Stephen D. Shea

Nature Neuroscience: doi:10.1038/nn.3669

a b

d

Rel

ativ

e vo

ltage

stra

in g

/ther

mo

cVo

ltage

/(dV/

dt)

1 432Time (s)

1 432Time (s)

c

1

0.5

Time lag (s)

Cor

rela

tion

–0.5 10.50–1

1

0.5

Time lag (s)

Cor

rela

tion

–0.5 10.50–1

!"##$%&%'()*+,-./"*%,01,!"#$%&'(")*"+*,-"*#.,/"0(*+"&*#.%(1&')2*&.($'&%,'")3*4%5*67%#$8.*&%-*,&%9.(*+&"#*('#18,%)."1(*&.($'&%,"&:*&.9"&0')2(*1(')2*%*)%(%88:*'#$8%),.0*,/.&#"9"1$8.*4&.05*%)0*%*+"'8*(,&%')*2%12.*4;8%9<53*=.*";(.&>.0*,/%,*,/.*$.%<*"+*,/.*(,&%')*2%12.*('2)%8*98"(.8:*#%,9/.0*,/.*$"'),*"+*#%7'#1#*&%,.*"+*9/%)2.*+"&*,/.*,/.&#"9"1$8.*('2)%83*4;5*!&"((*9"&&.8%,'")*"+*,/.*,-"*('2)%8(*(/"-(*%*8%2*"+*?@*#(*+"&*,/.*,/.&#"9"1$8.*&.8%,'>.*,"*,/.*(,&%')*2%12.3*A.%)*%)0*(303*,'#.*;.,-..)*$.%<(*-%(*?B*CDE*F*#(*495*!"#$%&'(")*"+*,/.*(,&%')*2%12.*-',/*,/.*0'++.&.),'%,.0*,/.&#"9"1$8.*('2)%8*(/"-(*%*2""0*#%,9/*"+*,/.*('2)%8*$.%<(3*405*!&"((*9"&&.8%,'")*"+*,/.*,-"*('2)%8(*')*405*(/"-(*%*2&.%,8:*&.019.0*8%2*"+*GF*#(*+"&*,/.*(,&%')*2%12.*&.8%,'>.*,"*,/.*,/.&#"9"1$8.3*A.%)*%)0*(303*,'#.*;.,-..)*$.%<(*-%(*H*CDE*B*#(3*

Nature Neuroscience: doi:10.1038/nn.3669

a b

c d

0

0.5

1

1.5

2

2.5

3

Identified GC Putative GC

RM

I

0.2 0.4 0.60

1

2

3

4

5

Coupling strength (r)

Cou

nt

5 10 15 20 25 300

5

10

Baseline firing (spikes/s) C

ount

Ranked odors

4

2

0

–2

–4

Res

pons

e (s

pike

s/s)

n = 28n = 28

!"##$%&%'()*+,-./"*%,01,!"#$%&'()'&&(&#*'"($'%"+$,(-.%/#/01'(!2,3(#$4(04'$/050'4(!2,(4+($+/(4055'"(0$(/6'0"(."+.'"/0',(-#3(70,/+8"#9(+5(04'$/050'4(!2,(-8"'*3(#$4(.%/#/01'(!2,(-:&#);3(,6+<,($+(4055'"'$)'(0$(,.+$/#$'+%,(#)/010/*(:'/<''$(/6'(/<+()'&&(.+.%&#/0+$,(=->?3(@(AB?C(D(@(EFBG?HC(I#$$JK60/$'*(=F(L4'$/050'4(!2,(6#4(#(9'#$(M(,F4F(:#,'&0$'("#/'(+5(AFNE(M(OF>>(,.0;',P,(-$(@(GB()'&&,(5"+9(QH(#$09#&,3(<60&'(.%/#/01'(!2,(6#4(#(:#,'&0$'("#/'(+5(AFHH(M(AFAO(-$(@(GB()'&&,(5"+9(QA(#$09#&,3F(-:3(R#$;'4(/%$0$8()%"1',(5+"(04'$/050'4(#$4(.%/#/01'(!2,(#"'(,090&#"F(L4'$/050'4(!2()%"1'(0,(.&+//'4(0$(8"'*C(.%/#/01'(!2,(#"'(.&+//'4(0$(:&#);C(#$4(/6'()+9:0$'4()%"1'(0,(.&+//'4(0$("'4F(S$&*(,.0;'("#/',(4%"0$8(/6'(+4+"(."','$/#/0+$(#"'(,6+<$F(-)3(R',.+$,'(9+4%&#/0+$(0$4'T(-RILC(,''(S$&0$'(I'/6+4,3(4+',($+/(4055'"(:'/<''$(/6'(/<+(8"+%.,F(U#)6(4#/#(.+0$/("'."','$/,(/6'(RIL(1#&%'(5+"(+$'()'&&F(I'#$(M(,F4F(RIL(04'$/050'4(!2(@(EFBQ(M(EF?GC($(@(GB()'&&,(5"+9(QH(#$09#&,V(RIL(.%/#/01'(!2(@(EFHB(M(EF>?C($(@(GB()'&&,(5"+9(QA(#$09#&,V(=->?3(@(AEOC(D(@(EFQBHEC(I#$$JK60/$'*(=F(-43(2+%.&0$8(+5(,.0;0$8(/+(:"'#/60$8(0,($+/(,08$050)#$/&*(4055'"'$/(0$(/6'(/<+(8"+%.,(-=-QO3(@(?NC(D(@(EFGQGHC(I#$$JK60/$'*(=3F(L$(:+/6(/6'(04'$/050'4(!2(-8"'*(+%/&0$'C($(@(O()'&&,(5"+9(>(#$09#&,3(#$4(.%/#/01'(!2(-:&#);C($(@(QG()'&&,(5"+9(O(#$09#&,3(8"+%.,C(9+,/()'&&,(,6+<(&0//&'()+%.&0$8(<0/6(:"'#/60$8F(

Nature Neuroscience: doi:10.1038/nn.3669

c

ba

Varia

nce

Varia

nce

*

Ranked odorsDuring

Ranked odorsOffset

Resp

onse

abo

ve b

asel

ine

(spi

kes/

s)

Resp

onse

abo

ve b

asel

ine

(spi

kes/

s)

0

5

10

15

20

25

30

35

Anesth Awake

Base

line

firin

g (s

pike

s/s) *

05

1015202530354045

0102030405060708090

50 100

Anesth AwakeDuring

Anesth AwakeOffset

*

-3

-2

-1

0

1

2

3

4

-3

-2

-1

0

1

2

3

4** *

!"##$%&%'()*+,-./"*%,01,!"#$%&'()*+,%$-+./*+0#%$**+102",34("**+*505"+*6$1+*505"7&"8"(&"(5+0#5'9'5:+#60()"*+1'56'(+'(&'9'&304+./*;+<(+0+*3=8$83405'$(+$,+#"44*+>(?@+#"44*+,%$-+@+0('-04*AB+%"#$%&'()*+1"%"+-0&"+,%$-+56"+*0-"+#"44+'(+=$56+56"+0102"+0(&+'*$,43%0("+0("*56"5'C"&+0('-04;+>0A+D8$(50("$3*+0#5'9'5:+*')(','#0(54:+'(#%"0*"&+'(+./*+0#%$**+56"+0("*56"5'C"&+>=40#2A+5$+0102"+>)%":A+5%0(*'5'$(+>E>FA+?+GFB+HI+?+J;JG@B+K0((7L6'5(":+EA;+K"0(+,'%'()+%05"+M+*;";-+>%"&+4'("+0(&+=40#2+4'("*+%"*8"#5'9"4:A+0%"+84$55"&;+N("*56"5'C"&+*505"+-"0(+M+*;&;+?+G;O@+M+J;PQR+-"0(+,'%'()+%05"+'(+56"+0102"+*505"+?+QS;JJ+M+T;GQ;+I0'%"&+&050+0%"+84$55"&+,$%+"0#6+#"44+1'56+56"+#$(("#5'()+4'("+4'(2'()+-"0(+,'%'()+%05"+,$%+0(+'(&'9'&304+#"44+'(+"0#6+*505";+>=A+!0(2"&+53('()+#3%9"*+&3%'()+G+*+$&$%+8%"*"(505'$(+0(&+Q+*+0,5"%+$&$%+$,,*"5+0%"+84$55"&+,$%+5%0(*'5'$(04+#"44*+'(+=$56+56"+0("*56"5'C"&+>=40#2+4'("A+0(&+0102"+>)%":+4'("A+*505";+H+&"($5"*+$&$%*+5605+"4'#'5"&+%"*8$(*"*+*')(','#0(54:+&',,"%"(5+,%$-+=0*"4'(";+>#A+U3('()+#3%9"+90%'0(#"+&3%'()+=$56+56"+G+*+$&$%+8%"*"(505'$(+0(&+Q+*+,$44$1'()+$&$%+$,,*"5+10*+)%"05"%+'(+56"+0102"+*505"+>&3%'()+-"0(+M+*;";-+?+QV;JT+M+@;TGR+0,5"%+?+G@;PT+M+QT;QSA+560(+'(+56"+0("*56"5'C"&+*505"+>&3%'()+?+Q;@T+M+J;FSR+0,5"%+?+S;FS+M+J;PFB+&3%'()+E>FA+?+GGB+HI+?+J;JTSR+0,5"%+E>FA+?+GFB+HI+?+J;JG@B+K0((7L6'5(":+EA;+<(&'9'&304+&050+8$'(5*+%"8%"*"(5+$("+#"44+0(&+-"0(+M+*;";-;+0%"+84$55"&+0*+6$%'C$(504+%"&+0(&+=40#2+4'("*+%"*8"#5'9"4:;+

Nature Neuroscience: doi:10.1038/nn.3669

ba

2

3

4

5

Still Run

Brea

thin

g fre

quen

cy (H

z)

6*

Still Run0

2

4

6

8

10

Spik

es/s

0 10 20 300

10

20

30

Stillrate (spikes/s)

Run

rate

(spi

kes/

s)c

Mov

eBr

eath

Spik

e

n = 33

n = 16

!"##$%&%'()*+,-./"*%,0!"#$%&'()"*&"+,(%-$*&'"%&."/#"0*,*&'"1*-$"2$%&'()"*&"342454-*4&!"6%7"89%5:3("-,%2("40"/#"%2-*;*-<"6+4--457=",():*,%-*4&"65*..3(7="%&.",>&&*&'";(342*-<"6-4:7!"?>&&*&'"1%)"5(%)>,(."4&"%&"%9*%33<"

,4-%-*&'"@-<,404%5"+%33";*%"%",4-%,<"(&24.(,!""A42454-4,"%2-*;*-<"1%)".*;*.(."*&-4"B")"+*&)="%&.",>&&*&'"+*&)"1*-$"

?C@"D"B"6,(."3*&()E"@2%3("+%,"*)"F")"%&."G"25H)"04,"342454-*4&="F"5I"04,"+,(%-$*&'"%&."F!J"5I"04,"/#"):*K*&'!"

6+7"L,(%-$*&'"0,(M>(&2<"*&2,(%)()"1*-$",>&&*&'!"L,(%-$*&'".>,*&'"-$("(&-*,(",(24,.*&'")())*4&"1%)"+*&&(."*&-4"B")"

*&-(,;%3)="%&."%"5(%&",%-(".>,*&'":(,*4.)"40",()-"4,".>,*&'":(,*4.)"40",>&&*&'"1%)"2%32>3%-(.!"N4,"%33"%&*5%3)"6&"O"

FP"2(33)"0,45"Q"%&*5%3)7="+,(%-$*&'")*'&*0*2%&-3<"*&2,(%)(.".>,*&'",>&&*&'"6C(%&"+,(%-$*&'",%-("R")!(!5!",()-"O"

B!PS"R"T!TQE",>&&*&'"U!PQ"R"T!FPE"V6FJ7"O"FJW=""XY"O""T!TTTTBP="C%&&Z[$*-&(<"V7!"627"/#"%2-*;*-<"*)"3%,'(3<"

*&;%,*%&-"1*-$"%2-*;*-<!"C(%&"):*K(",%-("R")!(!5!"+(-1((&":(,*4.)"40",()-"6Q!FJ"R"F!GP"):*K()H)7"%&.":(,*4.)"40"

*&2,(%)(."342454-*4&"6Q!TQ"R"F!JT"):*K()H)7"1%)"&4-")*'&*0*2%&-3<".*00(,(&-"6V6UB7"O"FTWW=":"O"T!WF="C%&&Z

[$*-&(<"V="3(0-7!""Y34--*&'"*&.*;*.>%3".%-%":4*&-)"65*..3(="3(0-"$*)-4',%5="&"O"UU"2(33)"0,45"FS"%&*5%3)7"*&.*2%-()"

%")>+Z:4:>3%-*4&"40"2(33)"*)"54.>3%-(."1*-$"%2-*;*-<!"\4--(.",(."3*&(",>&,%-("O")-*33,%-(!"

-1 0 1024681012

(Runrate-stillrate)(Runrate+stillrate)

Cou

nt Still > Run >Run Still

Nature Neuroscience: doi:10.1038/nn.3669

1

18

Neu

ron

Awake

– – /2 0 /2Respiratory phase (rad)

– – /2 0 /2Respiratory phase (rad)

3

2

1

Cou

nt

b

c

0.2 0.4 0.6 0.8

12

8

4

Cou

nt

Norm

alizedcount

1

0

Awake (n=18)

a

Coupling strength (r)

Inhalation Exhalation

Supplementary Figure 6. Assessment of respiratory coupling when GC spiking is aligned to breathing onset. (a)

Histogram (bin size = 0.1) of respiratory coupling strength (r) for awake state GCs. As with alignment to peak inspira-

tion, GCs still show weak respiratory coupling. (b) Heatmap depicting baseline respiratory phase spike histograms for all

that cell. White dots denote the mean phase angle of firing for each cell. A representative breath trace is shown in black

-

ness (gray).

Nature Neuroscience: doi:10.1038/nn.3669

1

1

0.8

0.6

0.4

0.2

432Quartile

Cou

plin

g st

regt

h (r)

SlowerFasterRespiratory rate

1

1

0.8

0.6

0.4

0.2

432Quartile

Cou

plin

g st

regt

h (r)

LongShortInspiration dur

1

1

0.8

0.6

0.4

0.2

432Quartile

Cou

plin

g st

regt

h (r)

LongShortExpiration dur

1

1

0.8

0.6

0.4

0.2

432Quartile

Cou

plin

g st

regt

h (r)

LargeSmallInspiration amp

a

dc

b

!"##$%&%'()*+,-./"*%,01!"#$%!&'$(#!)*+&,-./!-.!$0$%#!12(!-(!.*3!$!4#(+,3!*5!6-55#4#.)#(!-.!74#$3'!&$4$8#3#4(!7#30##.!0$%#5+,.#((!$.6!$.#(3'#(-$9!:,,!74#$3'(!54*8!;<!)#,,(!4#)*46#6!-.!;=!$0$%#!$.-8$,(!0#4#!6->-6#6!-.3*!

?+$43-,#(!5*4!#$)'!)#,,!$))*46-./!3*!*.#!*5!5*+4!74#$3'!&$4$8#3#4(9!@#(&-4$3*4A!)*+&,-./!(34#./3'!5*4!(&-%#(!6-6!

.*3!(A(3#8$3-)$,,A!>$4A!0-3'!$.A!*5!3'#!74#$3'!&$4$8#3#4(!0#!8#$(+4#6B!!74#$3'-./!4$3#!C$DE!-.(&-4$3*4A!6+4$3-*.!

C7DE!#F&-4$3*4A!6+4$3-*.!C)DE!$.6!!-.(&-4$3*4A!$8&,-3+6#!C6D9!!2*8&$4-./!3'#!6-(34-7+3-*.!*5!)*+&,-./!(34#./3'!

$)4*((!?+$43-,#(!5*4!#$)'!&$4$8#3#4E!0#!($0!.*!(-/.-5-)$.3!6-55#4#.)#(!C.!G!;<!)#,,(H!I!G!J9KL!C$DE!I!G!J9MM!C7DE!I!G!J9KJ!C)DE!I!G!J9MM!C6DE!N4+(%$,O"$,,-(D9!

Nature Neuroscience: doi:10.1038/nn.3669

12

8

4

0.2 0.80.60.4 1.0

Cou

nt

Coupling strength (r)

n = 18

12

8

4

0.2 0.80.60.4 1.0

Cou

nt

Coupling strength (r)

n = 18

12

8

4

0.2 0.80.60.4 1.0

Cou

nt

Coupling strength (r)

n = 18

a

b

c

Baseline

All other sniffs

First sniff

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

Nature Neuroscience: doi:10.1038/nn.3669

baseline firing (spikes/s)

a

024681012

kx iso

b

5 10

5

0

10

coun

t

base

line

firin

g (s

pike

s/s)

–3–2–1

0123

ranked odors ranked odors

KX (n = 4)iso (n = 19)

during after

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

KX (n = 3)iso (n = 19)

Nature Neuroscience: doi:10.1038/nn.3669

Table  1.  List  of  Odorants    

 

*  Denotes  odors  used  in  formulation  of  tuning  curves  

 

Monomolecular  Odorants  

 

    Natural  Odorants  

acetophenone*   ethyl  benzoylacetate  

 

3-­methyl-­2-­buten-­1-­ol  

 

anise  oil  

4-­allyanisole  

 

ethyl  butyrate   octanal*  

 

cedarwood  

 

2-­butenol  

 

ethyl  propionate   1-­pentanol*   cinnamon  oil  

butyl  formate*  

 

eucalyptol  

 

pentylacetate  

 

cloves  

butyl  propionate*  

 

eugenol*  

 

2-­phenylethanol  

 

cumin  

butyraldehyde  

 

heptanal   propionicaldehyde  

 

nutmeg  

camphor   2-­heptanone  

 

propyl  acetate   peanut  butter  

cineole*  

 

4-­heptanone   pyrrolidine  

 

peppermint  

 

citral   hexanal   valeraldehyde  

 

vanilla  extract  

 

cyclohexylacetate*  

 

2-­hexanone   valeric  acid*  

 

 

decanolactone  

 

limonene*  

 

   

 

   

 

 

 

 

Supplementary  

Nature Neuroscience: doi:10.1038/nn.3669