· web viewtable s1. top 5% of the genes of the tlr3 connectome

Table S1. Top 5% of the genes of the TLR3 connectome

Target gene Distance from TLR3 Rank P-value

(percentile) Median ratio Mean ratio Sphere Predicted route to TLR3Degrees of separation from TLR3

TLR3 0.000 0 0.000 0.000 0.000 0 TLR3 0

TRIF (TICAM1) 1.001 1 <0.001 0.059 0.050 0 TLR3[1.001]TRIF 1

MYD88 1.002 2 <0.001 0.059 0.050 0 TLR3[1.002]MYD88 1

IRAK2 1.023 3 <0.001 0.060 0.051 0 TLR3[1.023]IRAK2 1

UNC93B1 1.081 4 <0.001 0.064 0.054 0 TLR3[1.081]UNC93B1 1

HMGB1 1.128 5 <0.001 0.066 0.056 0 TLR3[1.128]HMGB1 1

TICAM2 1.134 6 <0.001 0.067 0.056 0 TLR3[1.134]TICAM2 1

LY86 1.187 7 0.001 0.070 0.059 0 TLR3[1.187]LY86 1

RNF216 1.363 8 0.001 0.080 0.068 0 TLR3[1.363]RNF216 1

SRC 1.405 9 0.001 0.083 0.070 0 TLR3[1.405]SRC 1

PIK3R1 1.615 10 0.001 0.095 0.080 0 TLR3[1.615]PIK3R1 1

IL1B 4.004 11 0.001 0.236 0.199 0 TLR3[1.002]MYD88[1.0]IL1B 2

IL1R1 4.004 12 0.001 0.236 0.199 0 TLR3[1.002]MYD88[1.0]IL1R1 2

IRAK1 4.004 13 0.001 0.236 0.199 1 TLR3[1.002]MYD88[1.0]IRAK1 2

IRAK4 4.004 14 0.001 0.236 0.199 1 TLR3[1.002]MYD88[1.0]IRAK4 2

IRF3 4.004 15 0.001 0.236 0.199 1 TLR3[1.001]TRIF[1.001]IRF3 2

IRF7 4.004 16 0.001 0.236 0.199 1 TLR3[1.002]MYD88[1.0]IRF7 2

TLR4 4.004 17 0.001 0.236 0.199 1 TLR3[1.002]MYD88[1.0]TLR4 2

IRAK3 4.006 18 0.001 0.236 0.199 1 TLR3[1.002]MYD88[1.001]IRAK3 2

FADD 4.008 19 0.002 0.236 0.199 1 TLR3[1.002]MYD88[1.002]FADD 2

TLR9 4.008 20 0.002 0.236 0.199 1 TLR3[1.002]MYD88[1.002]TLR9 2

IRF5 4.010 21 0.002 0.236 0.199 1 TLR3[1.002]MYD88[1.003]IRF5 2

TBK1 4.010 22 0.002 0.236 0.199 1 TLR3[1.001]TRIF[1.004]TBK1 2

TLR2 4.012 23 0.002 0.236 0.199 1 TLR3[1.002]MYD88[1.004]TLR2 2

TLR8 4.012 24 0.002 0.236 0.199 1 TLR3[1.002]MYD88[1.004]TLR8 2

CD14 4.016 25 0.002 0.236 0.199 1 TLR3[1.002]MYD88[1.006]CD14 2

TLR5 4.024 26 0.002 0.237 0.200 1 TLR3[1.002]MYD88[1.01]TLR5 2

TRAF6 4.028 27 0.002 0.237 0.200 1 TLR3[1.001]TRIF[1.013]TRAF6 2

LY96 4.042 28 0.002 0.238 0.201 1 TLR3[1.002]MYD88[1.019]LY96 2

RIPK3 4.052 29 0.002 0.238 0.201 1 TLR3[1.001]TRIF[1.025]RIPK3 2

TIRAP 4.060 30 0.002 0.239 0.202 1 TLR3[1.002]MYD88[1.028]TIRAP 2

IRF1 4.062 31 0.003 0.239 0.202 1 TLR3[1.002]MYD88[1.029]IRF1 2

RIP1 (RIPK1) 4.064 32 0.003 0.239 0.202 1 TLR3[1.001]TRIF[1.031]RIP1 2

AKT1 4.084 33 0.003 0.240 0.203 1 TLR3[1.002]MYD88[1.04]AKT1 2

STAP2 4.086 34 0.003 0.240 0.203 1 TLR3[1.002]MYD88[1.041]STAP2 2

RAC1 4.108 35 0.003 0.242 0.204 1 TLR3[1.002]MYD88[1.052]RAC1 2

TLR7 4.118 36 0.003 0.242 0.204 1 TLR3[1.002]MYD88[1.057]TLR7 2

TBP 4.282 37 0.003 0.252 0.213 1 TLR3[1.128]HMGB1[1.013]TBP 2

RAG1 4.294 38 0.003 0.253 0.213 1 TLR3[1.128]HMGB1[1.019]RAG1 2

NFKB1 4.302 39 0.003 0.253 0.214 1 TLR3[1.128]HMGB1[1.023]NFKB1 2

TNF 4.314 40 0.003 0.254 0.214 1 TLR3[1.128]HMGB1[1.029]TNF 2

PLAT 4.322 41 0.003 0.254 0.215 1 TLR3[1.128]HMGB1[1.033]PLAT 2

RAGE 4.350 42 0.003 0.256 0.216 1 TLR3[1.128]HMGB1[1.047]RAGE 2

RAG2 4.354 43 0.004 0.256 0.216 1 TLR3[1.128]HMGB1[1.049]RAG2 2

RB1 4.370 44 0.004 0.257 0.217 1 TLR3[1.134]TICAM2[1.051]RB1 2

CD180 4.374 45 0.004 0.257 0.217 1 TLR3[1.187]LY86[1.0]CD180 2

TP53 4.380 46 0.004 0.258 0.217 1 TLR3[1.134]TICAM2[1.056]TP53 2

TRAF1 4.396 47 0.004 0.259 0.218 1 TLR3[1.001]TRIF[1.197]TRAF1 2

BECN1 4.404 48 0.004 0.259 0.219 1 TLR3[1.128]HMGB1[1.074]BECN1 2

POU5F1 4.428 49 0.004 0.260 0.220 1 TLR3[1.128]HMGB1[1.086]POU5F1 2

PLG 4.432 50 0.004 0.261 0.220 1 TLR3[1.128]HMGB1[1.088]PLG 2

PELI1 4.522 51 0.004 0.266 0.225 1 TLR3[1.023]IRAK2[1.238]PELI1 2

SPI1 4.564 52 0.004 0.268 0.227 1 TLR3[1.128]HMGB1[1.154]SPI1 2

XPC 4.660 53 0.004 0.274 0.231 1 TLR3[1.128]HMGB1[1.202]XPC 2

SGCB 4.664 54 0.004 0.274 0.232 1 TLR3[1.128]HMGB1[1.204]SGCB 2

CDKN1B 4.696 55 0.005 0.276 0.233 1 TLR3[1.134]TICAM2[1.214]CDKN1B 2

HNRNPK 4.736 56 0.005 0.279 0.235 1 TLR3[1.128]HMGB1[1.24]HNRNPK 2

AR 4.750 57 0.005 0.279 0.236 1 TLR3[1.128]HMGB1[1.247]AR 2

SNCA 4.750 58 0.005 0.279 0.236 1 TLR3[1.128]HMGB1[1.247]SNCA 2

BCAR1 4.810 59 0.005 0.283 0.239 1 TLR3[1.405]SRC[1.0]BCAR1 2

CAV1 4.810 60 0.005 0.283 0.239 1 TLR3[1.405]SRC[1.0]CAV1 2

EGF 4.810 61 0.005 0.283 0.239 1 TLR3[1.405]SRC[1.0]EGF 2

EGFR 4.810 62 0.005 0.283 0.239 1 TLR3[1.405]SRC[1.0]EGFR 2

ESR1 4.810 63 0.005 0.283 0.239 1 TLR3[1.405]SRC[1.0]ESR1 2

GNB2L1 4.810 64 0.005 0.283 0.239 1 TLR3[1.405]SRC[1.0]GNB2L1 2

KHDRBS1 4.810 65 0.005 0.283 0.239 1 TLR3[1.405]SRC[1.0]KHDRBS1 2

LSM11 4.810 66 0.005 0.283 0.239 1 TLR3[1.002]MYD88[1.403]LSM11 2

PELP1 4.810 67 0.006 0.283 0.239 1 TLR3[1.405]SRC[1.0]PELP1 2

PTK2 4.810 68 0.006 0.283 0.239 1 TLR3[1.405]SRC[1.0]PTK2 2

PTPN1 4.810 69 0.006 0.283 0.239 1 TLR3[1.405]SRC[1.0]PTPN1 2

STAT3 4.810 70 0.006 0.283 0.239 1 TLR3[1.405]SRC[1.0]STAT3 2

CTNNB1 4.812 71 0.006 0.283 0.239 1 TLR3[1.405]SRC[1.001]CTNNB1 2

CTTN 4.812 72 0.006 0.283 0.239 1 TLR3[1.405]SRC[1.001]CTTN 2

GJA1 4.812 73 0.006 0.283 0.239 1 TLR3[1.405]SRC[1.001]GJA1 2

PTK2B 4.814 74 0.006 0.283 0.239 1 TLR3[1.405]SRC[1.002]PTK2B 2

GRIN2A 4.816 75 0.006 0.283 0.239 1 TLR3[1.405]SRC[1.003]GRIN2A 2

PTPRA 4.816 76 0.006 0.283 0.239 1 TLR3[1.405]SRC[1.003]PTPRA 2

BCR 4.818 77 0.006 0.283 0.239 1 TLR3[1.405]SRC[1.004]BCR 2

CTNND1 4.818 78 0.006 0.283 0.239 1 TLR3[1.405]SRC[1.004]CTNND1 2

PIK3CA 4.818 79 0.007 0.283 0.239 1 TLR3[1.405]SRC[1.004]PIK3CA 2

PDGFRB 4.820 80 0.007 0.284 0.239 1 TLR3[1.405]SRC[1.005]PDGFRB 2

PTPN21 4.820 81 0.007 0.284 0.239 1 TLR3[1.405]SRC[1.005]PTPN21 2

PXN 4.820 82 0.007 0.284 0.239 1 TLR3[1.405]SRC[1.005]PXN 2

ABL1 4.822 83 0.007 0.284 0.239 1 TLR3[1.405]SRC[1.006]ABL1 2

CSK 4.822 84 0.007 0.284 0.239 1 TLR3[1.405]SRC[1.006]CSK 2

EPHB2 4.824 85 0.007 0.284 0.240 1 TLR3[1.405]SRC[1.007]EPHB2 2

GRB2 4.824 86 0.007 0.284 0.240 1 TLR3[1.405]SRC[1.007]GRB2 2

HRAS 4.824 87 0.007 0.284 0.240 1 TLR3[1.405]SRC[1.007]HRAS 2

STAT1 4.824 88 0.007 0.284 0.240 1 TLR3[1.405]SRC[1.007]STAT1 2

DOCK1 4.826 89 0.007 0.284 0.240 1 TLR3[1.405]SRC[1.008]DOCK1 2

LAT 4.828 90 0.007 0.284 0.240 1 TLR3[1.405]SRC[1.009]LAT 2

ITGB3 4.830 91 0.008 0.284 0.240 1 TLR3[1.405]SRC[1.01]ITGB3 2

MPZL1 4.830 92 0.008 0.284 0.240 1 TLR3[1.405]SRC[1.01]MPZL1 2

PLCG1 4.830 93 0.008 0.284 0.240 1 TLR3[1.405]SRC[1.01]PLCG1 2

PAK2 4.832 94 0.008 0.284 0.240 1 TLR3[1.405]SRC[1.011]PAK2 2

DNM1 4.834 95 0.008 0.284 0.240 1 TLR3[1.405]SRC[1.012]DNM1 2

PVRL1 4.834 96 0.008 0.284 0.240 1 TLR3[1.405]SRC[1.012]PVRL1 2

RASA1 4.834 97 0.008 0.284 0.240 1 TLR3[1.405]SRC[1.012]RASA1 2

GAB2 4.836 98 0.008 0.284 0.240 1 TLR3[1.405]SRC[1.013]GAB2 2

MET 4.836 99 0.008 0.284 0.240 1 TLR3[1.405]SRC[1.013]MET 2

PRKCD 4.836 100 0.008 0.284 0.240 1 TLR3[1.405]SRC[1.013]PRKCD 2

SOS1 4.836 101 0.008 0.284 0.240 1 TLR3[1.405]SRC[1.013]SOS1 2

AFAP1 4.838 102 0.008 0.285 0.240 1 TLR3[1.405]SRC[1.014]AFAP1 2

ARRB1 4.838 103 0.009 0.285 0.240 1 TLR3[1.405]SRC[1.014]ARRB1 2

ESR2 4.838 104 0.009 0.285 0.240 1 TLR3[1.405]SRC[1.014]ESR2 2

RAPGEF1 4.838 105 0.009 0.285 0.240 1 TLR3[1.405]SRC[1.014]RAPGEF1 2

CDH1 4.840 106 0.009 0.285 0.240 1 TLR3[1.405]SRC[1.015]CDH1 2

DNM2 4.840 107 0.009 0.285 0.240 1 TLR3[1.405]SRC[1.015]DNM2 2

TRIP6 4.844 108 0.009 0.285 0.241 1 TLR3[1.405]SRC[1.017]TRIP6 2

TRPV1 4.844 109 0.009 0.285 0.241 1 TLR3[1.405]SRC[1.017]TRPV1 2

ASAP1 4.848 110 0.009 0.285 0.241 1 TLR3[1.405]SRC[1.019]ASAP1 2

MLLT4 4.848 111 0.009 0.285 0.241 1 TLR3[1.405]SRC[1.019]MLLT4 2

CDCP1 4.850 112 0.009 0.285 0.241 1 TLR3[1.405]SRC[1.02]CDCP1 2

FYN 4.850 113 0.009 0.285 0.241 1 TLR3[1.405]SRC[1.02]FYN 2

HSP90AA1 4.850 114 0.009 0.285 0.241 1 TLR3[1.405]SRC[1.02]HSP90AA1 2

IRS1 4.850 115 0.010 0.285 0.241 1 TLR3[1.405]SRC[1.02]IRS1 2

CAV2 4.858 116 0.010 0.286 0.241 1 TLR3[1.405]SRC[1.024]CAV2 2

PRKCE 4.860 117 0.010 0.286 0.241 1 TLR3[1.405]SRC[1.025]PRKCE 2

PRKCZ 4.860 118 0.010 0.286 0.241 1 TLR3[1.405]SRC[1.025]PRKCZ 2

SHB 4.860 119 0.010 0.286 0.241 1 TLR3[1.405]SRC[1.025]SHB 2

PRKCA 4.862 120 0.010 0.286 0.241 1 TLR3[1.405]SRC[1.026]PRKCA 2

CRK 4.868 121 0.010 0.286 0.242 2 TLR3[1.405]SRC[1.029]CRK 2

RET 4.874 122 0.010 0.287 0.242 2 TLR3[1.405]SRC[1.032]RET 2

FCGR2A 4.878 123 0.010 0.287 0.242 2 TLR3[1.405]SRC[1.034]FCGR2A 2

MED28 4.880 124 0.010 0.287 0.242 2 TLR3[1.405]SRC[1.035]MED28 2

BMX 4.882 125 0.010 0.287 0.242 2 TLR3[1.405]SRC[1.036]BMX 2

GP6 4.884 126 0.010 0.287 0.242 2 TLR3[1.405]SRC[1.037]GP6 2

WAS 4.884 127 0.011 0.287 0.242 2 TLR3[1.405]SRC[1.037]WAS 2

CDH5 4.888 128 0.011 0.288 0.243 2 TLR3[1.405]SRC[1.039]CDH5 2

GAB1 4.888 129 0.011 0.288 0.243 2 TLR3[1.405]SRC[1.039]GAB1 2

SH3BP2 4.888 130 0.011 0.288 0.243 2 TLR3[1.405]SRC[1.039]SH3BP2 2

PIK3CB 4.890 131 0.011 0.288 0.243 2 TLR3[1.405]SRC[1.04]PIK3CB 2

TJP1 4.890 132 0.011 0.288 0.243 2 TLR3[1.405]SRC[1.04]TJP1 2

ACTN1 4.892 133 0.011 0.288 0.243 2 TLR3[1.405]SRC[1.041]ACTN1 2

S100B 4.892 134 0.011 0.288 0.243 2 TLR3[1.405]SRC[1.041]S100B 2

CD247 4.894 135 0.011 0.288 0.243 2 TLR3[1.405]SRC[1.042]CD247 2

LYN 4.894 136 0.011 0.288 0.243 2 TLR3[1.405]SRC[1.042]LYN 2

MUC1 4.898 137 0.011 0.288 0.243 2 TLR3[1.405]SRC[1.044]MUC1 2

NCOA6 4.898 138 0.011 0.288 0.243 2 TLR3[1.405]SRC[1.044]NCOA6 2

NPHS1 4.900 139 0.012 0.288 0.243 2 TLR3[1.405]SRC[1.045]NPHS1 2

EPHA4 4.902 140 0.012 0.288 0.243 2 TLR3[1.405]SRC[1.046]EPHA4 2

ITK 4.902 141 0.012 0.288 0.243 2 TLR3[1.405]SRC[1.046]ITK 2

ADAM12 4.904 142 0.012 0.288 0.243 2 TLR3[1.405]SRC[1.047]ADAM12 2

SIRPA 4.904 143 0.012 0.288 0.243 2 TLR3[1.405]SRC[1.047]SIRPA 2

CEACAM1 4.906 144 0.012 0.289 0.244 2 TLR3[1.405]SRC[1.048]CEACAM1 2

PDCD6IP 4.906 145 0.012 0.289 0.244 2 TLR3[1.405]SRC[1.048]PDCD6IP 2

CD48 4.908 146 0.012 0.289 0.244 2 TLR3[1.405]SRC[1.049]CD48 2

CD79B 4.908 147 0.012 0.289 0.244 2 TLR3[1.405]SRC[1.049]CD79B 2

EPHA3 4.908 148 0.012 0.289 0.244 2 TLR3[1.405]SRC[1.049]EPHA3 2

EPS8 4.908 149 0.012 0.289 0.244 2 TLR3[1.405]SRC[1.049]EPS8 2

SYP 4.908 150 0.012 0.289 0.244 2 TLR3[1.405]SRC[1.049]SYP 2

ADAM15 4.914 151 0.013 0.289 0.244 2 TLR3[1.405]SRC[1.052]ADAM15 2

CD47 4.914 152 0.013 0.289 0.244 2 TLR3[1.405]SRC[1.052]CD47 2

CYBB 4.916 153 0.013 0.289 0.244 2 TLR3[1.405]SRC[1.053]CYBB 2

DAB2 4.916 154 0.013 0.289 0.244 2 TLR3[1.405]SRC[1.053]DAB2 2

SYN1 4.916 155 0.013 0.289 0.244 2 TLR3[1.405]SRC[1.053]SYN1 2

PLD2 4.918 156 0.013 0.289 0.244 2 TLR3[1.405]SRC[1.054]PLD2 2

RRAS 4.918 157 0.013 0.289 0.244 2 TLR3[1.405]SRC[1.054]RRAS 2

PDK1 4.922 158 0.013 0.290 0.244 2 TLR3[1.405]SRC[1.056]PDK1 2

AKAP12 4.924 159 0.013 0.290 0.244 2 TLR3[1.405]SRC[1.057]AKAP12 2

ITGA4 4.924 160 0.013 0.290 0.244 2 TLR3[1.405]SRC[1.057]ITGA4 2

OCLN 4.924 161 0.013 0.290 0.244 2 TLR3[1.405]SRC[1.057]OCLN 2

CAV3 4.928 162 0.013 0.290 0.245 2 TLR3[1.405]SRC[1.059]CAV3 2

TNFSF11 4.936 163 0.014 0.290 0.245 2 TLR3[1.405]SRC[1.063]TNFSF11 2

ADRB2 4.938 164 0.014 0.290 0.245 2 TLR3[1.405]SRC[1.064]ADRB2 2

DGKA 4.942 165 0.014 0.291 0.245 2 TLR3[1.405]SRC[1.066]DGKA 2

GSN 4.942 166 0.014 0.291 0.245 2 TLR3[1.405]SRC[1.066]GSN 2

ITGB5 4.944 167 0.014 0.291 0.245 2 TLR3[1.405]SRC[1.067]ITGB5 2

SDCBP 4.944 168 0.014 0.291 0.245 2 TLR3[1.405]SRC[1.067]SDCBP 2

ITGA2 4.948 169 0.014 0.291 0.246 2 TLR3[1.405]SRC[1.069]ITGA2 2

NCAN 4.950 170 0.014 0.291 0.246 2 TLR3[1.128]HMGB1[1.347]NCAN 2

DNM3 4.956 171 0.014 0.292 0.246 2 TLR3[1.405]SRC[1.073]DNM3 2

SKAP1 4.960 172 0.014 0.292 0.246 2 TLR3[1.405]SRC[1.075]SKAP1 2

DOK1 4.968 173 0.014 0.292 0.247 2 TLR3[1.405]SRC[1.079]DOK1 2

ND2 4.970 174 0.014 0.292 0.247 2 TLR3[1.405]SRC[1.08]ND2 2

NEDD9 4.980 175 0.015 0.293 0.247 2 TLR3[1.405]SRC[1.085]NEDD9 2

MAP2 4.986 176 0.015 0.293 0.248 2 TLR3[1.405]SRC[1.088]MAP2 2

SRCIN1 4.986 177 0.015 0.293 0.248 2 TLR3[1.405]SRC[1.088]SRCIN1 2

EPHA2 4.990 178 0.015 0.294 0.248 2 TLR3[1.405]SRC[1.09]EPHA2 2

F2RL2 4.990 179 0.015 0.294 0.248 2 TLR3[1.405]SRC[1.09]F2RL2 2

NFATC1 4.996 180 0.015 0.294 0.248 2 TLR3[1.405]SRC[1.093]NFATC1 2

PIK3CD 4.996 181 0.015 0.294 0.248 2 TLR3[1.405]SRC[1.093]PIK3CD 2

DAG1 5.020 182 0.015 0.295 0.249 2 TLR3[1.405]SRC[1.105]DAG1 2

SP1 5.032 183 0.015 0.296 0.250 2 TLR3[1.405]SRC[1.111]SP1 2

PTPN23 5.050 184 0.015 0.297 0.251 2 TLR3[1.405]SRC[1.12]PTPN23 2

CDC37 5.052 185 0.015 0.297 0.251 2 TLR3[1.405]SRC[1.121]CDC37 2

LIME1 5.070 186 0.015 0.298 0.252 2 TLR3[1.405]SRC[1.13]LIME1 2

PDIA3 5.074 187 0.016 0.298 0.252 2 TLR3[1.405]SRC[1.132]PDIA3 2

RAF1 5.074 188 0.016 0.298 0.252 2 TLR3[1.405]SRC[1.132]RAF1 2

ITGB7 5.078 189 0.016 0.299 0.252 2 TLR3[1.405]SRC[1.134]ITGB7 2

MPP2 5.078 190 0.016 0.299 0.252 2 TLR3[1.405]SRC[1.134]MPP2 2

CORO7 5.086 191 0.016 0.299 0.253 2 TLR3[1.405]SRC[1.138]CORO7 2

CD2 5.094 192 0.016 0.300 0.253 2 TLR3[1.405]SRC[1.142]CD2 2

ITGB6 5.098 193 0.016 0.300 0.253 2 TLR3[1.405]SRC[1.144]ITGB6 2

ITGB8 5.098 194 0.016 0.300 0.253 2 TLR3[1.405]SRC[1.144]ITGB8 2

SHC2 5.098 195 0.016 0.300 0.253 2 TLR3[1.405]SRC[1.144]SHC2 2

BAI1 5.102 196 0.016 0.300 0.253 2 TLR3[1.405]SRC[1.146]BAI1 2

ARHGDIA 5.122 197 0.016 0.301 0.254 2 TLR3[1.405]SRC[1.156]ARHGDIA 2

SEMA6B 5.136 198 0.016 0.302 0.255 2 TLR3[1.405]SRC[1.163]SEMA6B 2

ERBB2 5.148 199 0.017 0.303 0.256 2 TLR3[1.405]SRC[1.169]ERBB2 2

ARHGAP1 5.150 200 0.017 0.303 0.256 2 TLR3[1.405]SRC[1.17]ARHGAP1 2

HOXD8 5.152 201 0.017 0.303 0.256 2 TLR3[1.128]HMGB1[1.448]HOXD8 2

GTF2A1 5.156 202 0.017 0.303 0.256 2 TLR3[1.128]HMGB1[1.45]GTF2A1 2

C1QBP 5.156 203 0.017 0.303 0.256 2 TLR3[1.405]SRC[1.173]C1QBP 2

CD44 5.166 204 0.017 0.304 0.256 2 TLR3[1.405]SRC[1.178]CD44 2

DVL2 5.166 205 0.017 0.304 0.256 2 TLR3[1.405]SRC[1.178]DVL2 2

MYCBPAP 5.166 206 0.017 0.304 0.256 2 TLR3[1.405]SRC[1.178]MYCBPAP 2

LAT2 5.174 207 0.017 0.304 0.257 2 TLR3[1.405]SRC[1.182]LAT2 2

VDR 5.174 208 0.017 0.304 0.257 2 TLR3[1.405]SRC[1.182]VDR 2

RELA 5.178 209 0.017 0.305 0.257 2 TLR3[1.128]HMGB1[1.461]RELA 2

RXRA 5.178 210 0.017 0.305 0.257 2 TLR3[1.405]SRC[1.184]RXRA 2

KIR2DL4 5.180 211 0.018 0.305 0.257 2 TLR3[1.405]SRC[1.185]KIR2DL4 2

HCN4 5.184 212 0.018 0.305 0.257 2 TLR3[1.405]SRC[1.187]HCN4 2

TNFRSF1A 5.184 213 0.018 0.305 0.257 2 TLR3[1.405]SRC[1.187]TNFRSF1A 2

PDGFRA 5.192 214 0.018 0.305 0.258 2 TLR3[1.405]SRC[1.191]PDGFRA 2

HTT 5.200 215 0.018 0.306 0.258 2 TLR3[1.405]SRC[1.195]HTT 2

MCAT 5.204 216 0.018 0.306 0.258 2 TLR3[1.405]SRC[1.197]MCAT 2

CD63 5.206 217 0.018 0.306 0.258 2 TLR3[1.405]SRC[1.198]CD63 2

NDUFB11 5.208 218 0.018 0.306 0.259 2 TLR3[1.405]SRC[1.199]NDUFB11 2

AMH 5.212 219 0.018 0.307 0.259 2 TLR3[1.405]SRC[1.201]AMH 2

CD79A 5.212 220 0.018 0.307 0.259 2 TLR3[1.405]SRC[1.201]CD79A 2

DSG2 5.212 221 0.018 0.307 0.259 2 TLR3[1.405]SRC[1.201]DSG2 2

RARA 5.214 222 0.018 0.307 0.259 2 TLR3[1.405]SRC[1.202]RARA 2

TLE1 5.222 223 0.019 0.307 0.259 2 TLR3[1.128]HMGB1[1.483]TLE1 2

FBLIM1 5.224 224 0.019 0.307 0.259 2 TLR3[1.405]SRC[1.207]FBLIM1 2

CBL 5.230 225 0.019 0.308 0.260 2 TLR3[1.615]PIK3R1[1.0]CBL 2

CD28 5.230 226 0.019 0.308 0.260 2 TLR3[1.615]PIK3R1[1.0]CD28 2

INSR 5.230 227 0.019 0.308 0.260 2 TLR3[1.615]PIK3R1[1.0]INSR 2

IRS2 5.230 228 0.019 0.308 0.260 2 TLR3[1.615]PIK3R1[1.0]IRS2 2

SHC1 5.230 229 0.019 0.308 0.260 2 TLR3[1.615]PIK3R1[1.0]SHC1 2

IGF1R 5.232 230 0.019 0.308 0.260 2 TLR3[1.615]PIK3R1[1.001]IGF1R 2

KIT 5.232 231 0.019 0.308 0.260 2 TLR3[1.615]PIK3R1[1.001]KIT 2

PIAS4 5.232 232 0.019 0.308 0.260 2 TLR3[1.001]TRIF[1.615]PIAS4 2

TNFAIP3 5.232 233 0.019 0.308 0.260 2 TLR3[1.001]TRIF[1.615]TNFAIP3 2

CDC42 5.234 234 0.019 0.308 0.260 2 TLR3[1.615]PIK3R1[1.002]CDC42 2

ARHGDIB 5.236 235 0.020 0.308 0.260 2 TLR3[1.405]SRC[1.213]ARHGDIB 2

ERBB3 5.238 236 0.020 0.308 0.260 2 TLR3[1.615]PIK3R1[1.004]ERBB3 2

LCK 5.240 237 0.020 0.308 0.260 2 TLR3[1.615]PIK3R1[1.005]LCK 2

PTPN6 5.240 238 0.020 0.308 0.260 2 TLR3[1.615]PIK3R1[1.005]PTPN6 2

COASY 5.242 239 0.020 0.308 0.260 2 TLR3[1.405]SRC[1.216]COASY 2

VAV1 5.242 240 0.020 0.308 0.260 2 TLR3[1.615]PIK3R1[1.006]VAV1 2

UNC80 5.248 241 0.020 0.309 0.261 2 TLR3[1.405]SRC[1.219]UNC80 2

CD19 5.252 242 0.020 0.309 0.261 2 TLR3[1.615]PIK3R1[1.011]CD19 2

DDR2 5.252 243 0.020 0.309 0.261 2 TLR3[1.405]SRC[1.221]DDR2 2

TXN 5.262 244 0.020 0.310 0.261 2 TLR3[1.128]HMGB1[1.503]TXN 2

PRAM1 5.262 245 0.020 0.310 0.261 2 TLR3[1.405]SRC[1.226]PRAM1 2

PTH1R 5.262 246 0.020 0.310 0.261 2 TLR3[1.405]SRC[1.226]PTH1R 2

CBLB 5.266 247 0.021 0.310 0.261 2 TLR3[1.615]PIK3R1[1.018]CBLB 2


NFKBIA 5.268 249 0.021 0.310 0.262 2 TLR3[1.615]PIK3R1[1.019]NFKBIA 2

ARHGEF7 5.272 250 0.021 0.310 0.262 2 TLR3[1.615]PIK3R1[1.021]ARHGEF7 2

FGFR1 5.278 251 0.021 0.310 0.262 2 TLR3[1.615]PIK3R1[1.024]FGFR1 2

PPARD 5.280 252 0.021 0.311 0.262 2 TLR3[1.405]SRC[1.235]PPARD 2

PTPN11 5.282 253 0.021 0.311 0.262 2 TLR3[1.615]PIK3R1[1.026]PTPN11 2

JAK2 5.286 254 0.021 0.311 0.262 2 TLR3[1.615]PIK3R1[1.028]JAK2 2

NTRK1 5.286 255 0.021 0.311 0.262 2 TLR3[1.615]PIK3R1[1.028]NTRK1 2

PTPRZ1 5.298 256 0.021 0.312 0.263 2 TLR3[1.128]HMGB1[1.521]PTPRZ1 2

SCARB1 5.298 257 0.021 0.312 0.263 2 TLR3[1.405]SRC[1.244]SCARB1 2

SYK 5.300 258 0.021 0.312 0.263 2 TLR3[1.615]PIK3R1[1.035]SYK 2

FLT1 5.304 259 0.022 0.312 0.263 2 TLR3[1.615]PIK3R1[1.037]FLT1 2

PDLIM4 5.308 260 0.022 0.312 0.264 2 TLR3[1.405]SRC[1.249]PDLIM4 2

PRNP 5.308 261 0.022 0.312 0.264 2 TLR3[1.405]SRC[1.249]PRNP 2

TOP1 5.308 262 0.022 0.312 0.264 2 TLR3[1.405]SRC[1.249]TOP1 2

AGAP2 5.314 263 0.022 0.313 0.264 2 TLR3[1.615]PIK3R1[1.042]AGAP2 2

FES 5.314 264 0.022 0.313 0.264 2 TLR3[1.615]PIK3R1[1.042]FES 2

YWHAZ 5.314 265 0.022 0.313 0.264 2 TLR3[1.615]PIK3R1[1.042]YWHAZ 2

GNAQ 5.324 266 0.022 0.313 0.264 2 TLR3[1.615]PIK3R1[1.047]GNAQ 2

INPP5D 5.324 267 0.022 0.313 0.264 2 TLR3[1.615]PIK3R1[1.047]INPP5D 2

TEK 5.326 268 0.022 0.313 0.264 2 TLR3[1.615]PIK3R1[1.048]TEK 2

CTLA4 5.328 269 0.022 0.313 0.265 2 TLR3[1.615]PIK3R1[1.049]CTLA4 2

SDCBP2 5.330 270 0.022 0.314 0.265 2 TLR3[1.405]SRC[1.26]SDCBP2 2

SH3KBP1 5.338 271 0.023 0.314 0.265 2 TLR3[1.615]PIK3R1[1.054]SH3KBP1 2

SOS2 5.342 272 0.023 0.314 0.265 2 TLR3[1.615]PIK3R1[1.056]SOS2 2

PLCG2 5.346 273 0.023 0.314 0.265 2 TLR3[1.615]PIK3R1[1.058]PLCG2 2

RGS16 5.356 274 0.023 0.315 0.266 2 TLR3[1.405]SRC[1.273]RGS16 2

TRPC6 5.362 275 0.023 0.315 0.266 2 TLR3[1.405]SRC[1.276]TRPC6 2

XBP1 5.368 276 0.023 0.316 0.267 2 TLR3[1.615]PIK3R1[1.069]XBP1 2

FGFR2 5.374 277 0.023 0.316 0.267 2 TLR3[1.615]PIK3R1[1.072]FGFR2 2

FMN1 5.386 278 0.023 0.317 0.267 2 TLR3[1.405]SRC[1.288]FMN1 2

ACTB 5.388 279 0.023 0.317 0.268 2 TLR3[1.405]SRC[1.289]ACTB 2

LCP2 5.388 280 0.023 0.317 0.268 2 TLR3[1.405]SRC[1.289]LCP2 2

UBE2L3 5.388 281 0.023 0.317 0.268 2 TLR3[1.363]RNF216[1.331]UBE2L3 2

SYNJ2 5.390 282 0.023 0.317 0.268 2 TLR3[1.615]PIK3R1[1.08]SYNJ2 2

KLHL31 5.392 283 0.024 0.317 0.268 2 TLR3[1.405]SRC[1.291]KLHL31 2

ARRB2 5.408 284 0.024 0.318 0.269 2 TLR3[1.405]SRC[1.299]ARRB2 2

ADRBK1 5.412 285 0.024 0.318 0.269 2 TLR3[1.405]SRC[1.301]ADRBK1 2

INPPL1 5.416 286 0.024 0.319 0.269 2 TLR3[1.615]PIK3R1[1.093]INPPL1 2

SHANK3 5.418 287 0.024 0.319 0.269 2 TLR3[1.615]PIK3R1[1.094]SHANK3 2

ASAP2 5.422 288 0.024 0.319 0.269 2 TLR3[1.405]SRC[1.306]ASAP2 2

PEMT 5.422 289 0.024 0.319 0.269 2 TLR3[1.405]SRC[1.306]PEMT 2

CRKL 5.424 290 0.024 0.319 0.269 2 TLR3[1.615]PIK3R1[1.097]CRKL 2

MECP2 5.454 291 0.024 0.321 0.271 2 TLR3[1.128]HMGB1[1.599]MECP2 2

NKTR 5.468 292 0.024 0.322 0.271 2 TLR3[1.615]PIK3R1[1.119]NKTR 2

BLVRA 5.472 293 0.024 0.322 0.272 2 TLR3[1.615]PIK3R1[1.121]BLVRA 2

EPOR 5.472 294 0.024 0.322 0.272 2 TLR3[1.615]PIK3R1[1.121]EPOR 2

NR3C1 5.474 295 0.025 0.322 0.272 2 TLR3[1.128]HMGB1[1.609]NR3C1 2

SH3BP1 5.474 296 0.025 0.322 0.272 2 TLR3[1.405]SRC[1.332]SH3BP1 2

LTK 5.476 297 0.025 0.322 0.272 2 TLR3[1.615]PIK3R1[1.123]LTK 2

CDK1 5.486 298 0.025 0.323 0.272 2 TLR3[1.128]HMGB1[1.615]CDK1 2

TP63 5.486 299 0.025 0.323 0.272 2 TLR3[1.128]HMGB1[1.615]TP63 2

TP73 5.486 300 0.025 0.323 0.272 2 TLR3[1.134]TICAM2[1.609]TP73 2

TNIP3 5.490 301 0.025 0.323 0.273 2 TLR3[1.128]HMGB1[1.617]TNIP3 2

SRF 5.500 302 0.025 0.324 0.273 2 TLR3[1.405]SRC[1.345]SRF 2

CD3E 5.506 303 0.025 0.324 0.273 2 TLR3[1.615]PIK3R1[1.138]CD3E 2

CTC-298B17 5.514 304 0.025 0.324 0.274 2 TLR3[1.405]SRC[1.352] CTC-298B17 2

ACTA1 5.552 305 0.025 0.327 0.276 2 TLR3[1.405]SRC[1.371]ACTA1 2

ZFPM2 5.554 306 0.025 0.327 0.276 2 TLR3[1.615]PIK3R1[1.162]ZFPM2 2

EVL 5.556 307 0.026 0.327 0.276 2 TLR3[1.405]SRC[1.373]EVL 2

PGR 5.588 308 0.026 0.329 0.277 2 TLR3[1.128]HMGB1[1.666]PGR 2

ARAF 5.594 309 0.026 0.329 0.278 2 TLR3[1.615]PIK3R1[1.182]ARAF 2

CD7 5.594 310 0.026 0.329 0.278 2 TLR3[1.615]PIK3R1[1.182]CD7 2



TSN 5.612 313 0.026 0.330 0.279 2 TLR3[1.615]PIK3R1[1.191]TSN 2

EDNRA 5.624 314 0.026 0.331 0.279 2 TLR3[1.405]SRC[1.407]EDNRA 2

AES 5.626 315 0.026 0.331 0.279 2 TLR3[1.128]HMGB1[1.685]AES 2

GAB3 5.628 316 0.026 0.331 0.279 2 TLR3[1.405]SRC[1.409]GAB3 2

CSNK1A1 5.678 317 0.026 0.334 0.282 2 TLR3[1.128]HMGB1[1.711]CSNK1A1 2

FOXO1 5.678 318 0.026 0.334 0.282 2 TLR3[1.405]SRC[1.434]FOXO1 2

TLR10 5.678 319 0.027 0.334 0.282 2 TLR3[1.128]HMGB1[1.711]TLR10 2

SHANK2 5.702 320 0.027 0.335 0.283 2 TLR3[1.405]SRC[1.446]SHANK2 2

PDGFRL 5.714 321 0.027 0.336 0.284 2 TLR3[1.405]SRC[1.452]PDGFRL 2

ADRB3 5.732 322 0.027 0.337 0.285 2 TLR3[1.405]SRC[1.461]ADRB3 2

UBC 5.768 323 0.027 0.339 0.286 2 TLR3[1.128]HMGB1[1.756]UBC 2

AHR 5.776 324 0.027 0.340 0.287 2 TLR3[1.405]SRC[1.483]AHR 2

HDAC3 5.788 325 0.027 0.340 0.287 2 TLR3[1.405]SRC[1.489]HDAC3 2

GHR 5.802 326 0.027 0.341 0.288 2 TLR3[1.615]PIK3R1[1.286]GHR 2

RICS 5.834 327 0.027 0.343 0.290 2 TLR3[1.405]SRC[1.512]RICS 2

LNX1 5.838 328 0.027 0.343 0.290 2 TLR3[1.405]SRC[1.514]LNX1 2

ARHGAP17 5.856 329 0.027 0.344 0.291 2 TLR3[1.405]SRC[1.523]ARHGAP17 2

HOXB1 5.878 330 0.027 0.346 0.292 2 TLR3[1.128]HMGB1[1.811]HOXB1 2

HOXB3 5.878 331 0.028 0.346 0.292 2 TLR3[1.128]HMGB1[1.811]HOXB3 2

HOXC6 5.878 332 0.028 0.346 0.292 2 TLR3[1.128]HMGB1[1.811]HOXC6 2




PPP3R1 5.900 336 0.028 0.347 0.293 2 TLR3[1.002]MYD88[1.948]PPP3R1 2

ARNT 5.918 337 0.028 0.348 0.294 2 TLR3[1.405]SRC[1.554]ARNT 2

CSF1R 5.942 338 0.028 0.350 0.295 2 TLR3[1.405]SRC[1.566]CSF1R 2

NR1I2 5.942 339 0.028 0.350 0.295 2 TLR3[1.405]SRC[1.566]NR1I2 2

THRB 5.948 340 0.028 0.350 0.295 2 TLR3[1.405]SRC[1.569]THRB 2

TRAF3 5.958 341 0.028 0.350 0.296 2 TLR3[1.405]SRC[1.574]TRAF3 2

MYLK 5.968 342 0.028 0.351 0.296 2 TLR3[1.405]SRC[1.579]MYLK 2

CSF2RA 5.982 343 0.029 0.352 0.297 2 TLR3[1.615]PIK3R1[1.376]CSF2RA 2

SPOP 5.986 344 0.029 0.352 0.297 2 TLR3[1.002]MYD88[1.991]SPOP 2

TRPV4 6.024 345 0.029 0.354 0.299 2 TLR3[1.405]SRC[1.607]TRPV4 2

PPARA 6.040 346 0.029 0.355 0.300 2 TLR3[1.405]SRC[1.615]PPARA 2

TGM2 6.040 347 0.029 0.355 0.300 2 TLR3[1.405]SRC[1.615]TGM2 2

TYRO3 6.040 348 0.029 0.355 0.300 2 TLR3[1.405]SRC[1.615]TYRO3 2

BRCA1 6.044 349 0.029 0.356 0.300 2 TLR3[1.405]SRC[1.617]BRCA1 2

AXL 6.086 350 0.029 0.358 0.302 2 TLR3[1.405]SRC[1.638]AXL 2

HNF1A 6.102 351 0.029 0.359 0.303 2 TLR3[1.405]SRC[1.646]HNF1A 2

IL6ST 6.102 352 0.029 0.359 0.303 2 TLR3[1.615]PIK3R1[1.436]IL6ST 2

SMAD3 6.102 353 0.029 0.359 0.303 2 TLR3[1.405]SRC[1.646]SMAD3 2

61E3.4 6.142 354 0.029 0.361 0.305 2 TLR3[1.405]SRC[1.666]61E3.4 2

LOC100288704 6.142 355 0.030 0.361 0.305 2 TLR3[1.405]SRC[1.666]LOC100288704 2

PIK3C2A 6.142 356 0.030 0.361 0.305 2 TLR3[1.405]SRC[1.666]PIK3C2A 2

NEURL 6.164 357 0.030 0.363 0.306 2 TLR3[1.405]SRC[1.677]NEURL 2

DRD4 6.274 358 0.030 0.369 0.312 2 TLR3[1.405]SRC[1.732]DRD4 2

UBE2C 6.276 359 0.030 0.369 0.312 2 TLR3[1.363]RNF216[1.775]UBE2C 2

UBE2H 6.276 360 0.030 0.369 0.312 2 TLR3[1.363]RNF216[1.775]UBE2H 2

UBE2L6 6.276 361 0.030 0.369 0.312 2 TLR3[1.363]RNF216[1.775]UBE2L6 2

ARR3 6.330 362 0.030 0.372 0.314 2 TLR3[1.405]SRC[1.76]ARR3 2

TRIP4 6.336 363 0.030 0.373 0.315 2 TLR3[1.405]SRC[1.763]TRIP4 2

DUSP2 6.426 364 0.030 0.378 0.319 2 TLR3[1.002]MYD88[2.211]DUSP2 2

PPP3CA 6.426 365 0.030 0.378 0.319 2 TLR3[1.002]MYD88[2.211]PPP3CA 2

PPP3CB 6.426 366 0.030 0.378 0.319 2 TLR3[1.002]MYD88[2.211]PPP3CB 2

PPP3CC 6.426 367 0.031 0.378 0.319 2 TLR3[1.002]MYD88[2.211]PPP3CC 2

PPP3R2 6.426 368 0.031 0.378 0.319 2 TLR3[1.002]MYD88[2.211]PPP3R2 2

SPRR2A 6.432 369 0.031 0.378 0.319 2 TLR3[1.405]SRC[1.811]SPRR2A 2

PDE6G 6.458 370 0.031 0.380 0.321 2 TLR3[1.405]SRC[1.824]PDE6G 2

SMARCE1 6.458 371 0.031 0.380 0.321 2 TLR3[1.405]SRC[1.824]SMARCE1 2

SEPT2 6.460 372 0.031 0.380 0.321 2 TLR3[1.615]PIK3R1[1.615]SEPT2 2

HBA1 6.460 373 0.031 0.380 0.321 2 TLR3[1.615]PIK3R1[1.615]HBA1 2

CD5 6.460 374 0.031 0.380 0.321 2 TLR3[1.615]PIK3R1[1.615]CD5 2

CMIP 6.460 375 0.031 0.380 0.321 2 TLR3[1.615]PIK3R1[1.615]CMIP 2

IFNAR1 6.460 376 0.031 0.380 0.321 2 TLR3[1.615]PIK3R1[1.615]IFNAR1 2

RRAS2 6.460 377 0.031 0.380 0.321 2 TLR3[1.615]PIK3R1[1.615]RRAS2 2

SSTR2 6.460 378 0.031 0.380 0.321 2 TLR3[1.615]PIK3R1[1.615]SSTR2 2

TUBA1B 6.460 379 0.032 0.380 0.321 2 TLR3[1.615]PIK3R1[1.615]TUBA1B 2

WASF3 6.460 380 0.032 0.380 0.321 2 TLR3[1.615]PIK3R1[1.615]WASF3 2

MICAL1 6.492 381 0.032 0.382 0.322 2 TLR3[1.405]SRC[1.841]MICAL1 2

RPL10 6.526 382 0.032 0.384 0.324 2 TLR3[1.405]SRC[1.858]RPL10 2

SLC9A2 6.526 383 0.032 0.384 0.324 2 TLR3[1.405]SRC[1.858]SLC9A2 2

SOCS6 6.534 384 0.032 0.384 0.324 2 TLR3[1.615]PIK3R1[1.652]SOCS6 2

TKT 6.582 385 0.032 0.387 0.327 2 TLR3[1.405]SRC[1.886]TKT 2

PIK3C2B 6.652 386 0.032 0.391 0.330 2 TLR3[1.615]PIK3R1[1.711]PIK3C2B 2

TLN1 6.806 387 0.032 0.400 0.338 2 TLR3[1.615]PIK3R1[1.788]TLN1 2

ITGAE 6.848 388 0.032 0.403 0.340 2 TLR3[1.405]SRC[2.019]ITGAE 2

RIN3 7.128 389 0.032 0.419 0.354 2 TLR3[1.405]SRC[2.159]RIN3 2

ENKUR 7.220 390 0.032 0.425 0.358 2 TLR3[1.615]PIK3R1[1.995]ENKUR 2

ID4 7.364 391 0.033 0.433 0.366 2 TLR3[1.405]SRC[2.277]ID4 2

RTN4 7.396 392 0.033 0.435 0.367 2 TLR3[1.405]SRC[2.293]RTN4 2

DLGAP1 7.628 393 0.033 0.449 0.379 2 TLR3[1.405]SRC[2.409]DLGAP1 2

ITGAD 7.722 394 0.033 0.454 0.383 2 TLR3[1.405]SRC[2.456]ITGAD 2

DLGAP4 7.976 395 0.033 0.469 0.396 2 TLR3[1.405]SRC[2.583]DLGAP4 2

AAX38255.1 8.030 396 0.033 0.472 0.399 2 TLR3[1.405]SRC[2.61]AAX38255.1 2

CLLU1OS 8.030 397 0.033 0.472 0.399 2 TLR3[1.405]SRC[2.61]CLLU1OS 2

COQ2 8.030 398 0.033 0.472 0.399 2 TLR3[1.405]SRC[2.61]COQ2 2

FAM86C 8.030 399 0.033 0.472 0.399 2 TLR3[1.405]SRC[2.61]FAM86C 2

MRGPRX2 8.030 400 0.033 0.472 0.399 2 TLR3[1.405]SRC[2.61]MRGPRX2 2

RHBDF1 8.030 401 0.033 0.472 0.399 2 TLR3[1.405]SRC[2.61]RHBDF1 2

SLC25A36 8.030 402 0.033 0.472 0.399 2 TLR3[1.405]SRC[2.61]SLC25A36 2

ZNF23 8.030 403 0.034 0.472 0.399 2 TLR3[1.405]SRC[2.61]ZNF23 2

72818 8.086 404 0.034 0.476 0.401 2 TLR3[1.405]SRC[2.638]72818 2

ACTA2 8.086 405 0.034 0.476 0.401 2 TLR3[1.405]SRC[2.638]ACTA2 2

ACTBL2 8.086 406 0.034 0.476 0.401 2 TLR3[1.405]SRC[2.638]ACTBL2 2

ACTG2 8.086 407 0.034 0.476 0.401 2 TLR3[1.405]SRC[2.638]ACTG2 2

ACTL6A 8.086 408 0.034 0.476 0.401 2 TLR3[1.405]SRC[2.638]ACTL6A 2

ACTL6B 8.086 409 0.034 0.476 0.401 2 TLR3[1.405]SRC[2.638]ACTL6B 2

ACTL7A 8.086 410 0.034 0.476 0.401 2 TLR3[1.405]SRC[2.638]ACTL7A 2

ACTL7B 8.086 411 0.034 0.476 0.401 2 TLR3[1.405]SRC[2.638]ACTL7B 2

ACTR6 8.086 412 0.034 0.476 0.401 2 TLR3[1.405]SRC[2.638]ACTR6 2

ACTRT2 8.086 413 0.034 0.476 0.401 2 TLR3[1.405]SRC[2.638]ACTRT2 2

APOBEC3D 8.086 414 0.034 0.476 0.401 2 TLR3[1.405]SRC[2.638]APOBEC3D 2

ARPM1 8.086 415 0.035 0.476 0.401 2 TLR3[1.405]SRC[2.638]ARPM1 2

CD97 8.086 416 0.035 0.476 0.401 2 TLR3[1.405]SRC[2.638]CD97 2

FAM187B 8.086 417 0.035 0.476 0.401 2 TLR3[1.405]SRC[2.638]FAM187B 2

LOC653269 8.086 418 0.035 0.476 0.401 2 TLR3[1.405]SRC[2.638]LOC653269 2

LOC653781 8.086 419 0.035 0.476 0.401 2 TLR3[1.405]SRC[2.638]LOC653781 2

POTEE 8.086 420 0.035 0.476 0.401 2 TLR3[1.405]SRC[2.638]POTEE 2

POTEF 8.086 421 0.035 0.476 0.401 2 TLR3[1.405]SRC[2.638]POTEF 2

PPP1R9A 8.086 422 0.035 0.476 0.401 2 TLR3[1.405]SRC[2.638]PPP1R9A 2

TMSB10 8.086 423 0.035 0.476 0.401 2 TLR3[1.405]SRC[2.638]TMSB10 2

TMSB15A 8.086 424 0.035 0.476 0.401 2 TLR3[1.405]SRC[2.638]TMSB15A 2

TMSB4Y 8.086 425 0.035 0.476 0.401 2 TLR3[1.405]SRC[2.638]TMSB4Y 2

TMSL3 8.086 426 0.035 0.476 0.401 2 TLR3[1.405]SRC[2.638]TMSL3 2

HCN2 8.184 427 0.036 0.481 0.406 2 TLR3[1.405]SRC[2.687]HCN2 2

LCMT1 8.228 428 0.036 0.484 0.409 2 TLR3[1.405]SRC[2.709]LCMT1 2

PPP2R2B 8.228 429 0.036 0.484 0.409 2 TLR3[1.405]SRC[2.709]PPP2R2B 2

PPP2R2D 8.228 430 0.036 0.484 0.409 2 TLR3[1.405]SRC[2.709]PPP2R2D 2


PPP2R3C 8.228 432 0.036 0.484 0.409 2 TLR3[1.405]SRC[2.709]PPP2R3C 2


PPP2R5D 8.228 434 0.036 0.484 0.409 2 TLR3[1.405]SRC[2.709]PPP2R5D 2

PPP2R5E 8.228 435 0.036 0.484 0.409 2 TLR3[1.405]SRC[2.709]PPP2R5E 2

CAST 8.394 436 0.036 0.494 0.417 2 TLR3[1.405]SRC[2.792]CAST 2

ALS2CR12 8.942 437 0.036 0.526 0.444 2 TLR3[1.405]SRC[3.066]ALS2CR12 2

CELSR2 8.942 438 0.036 0.526 0.444 2 TLR3[1.405]SRC[3.066]CELSR2 2

ISG20L2 8.942 439 0.037 0.526 0.444 2 TLR3[1.405]SRC[3.066]ISG20L2 2

OGN 8.942 440 0.037 0.526 0.444 2 TLR3[1.405]SRC[3.066]OGN 2

PHACTR2 8.942 441 0.037 0.526 0.444 2 TLR3[1.405]SRC[3.066]PHACTR2 2

RALGAPB 8.942 442 0.037 0.526 0.444 2 TLR3[1.405]SRC[3.066]RALGAPB 2

TULP4 8.942 443 0.037 0.526 0.444 2 TLR3[1.405]SRC[3.066]TULP4 2

ZP2 8.942 444 0.037 0.526 0.444 2 TLR3[1.405]SRC[3.066]ZP2 2

CREBBP 9.006 445 0.037 0.530 0.447 2 TLR3[1.001]TRIF[1.001]IRF3[1.0]CREBBP 3

IKBKE 9.006 446 0.037 0.530 0.447 2 TLR3[1.001]TRIF[1.001]IRF3[1.0]IKBKE 3

IL18 9.006 447 0.037 0.530 0.447 2 TLR3[1.002]MYD88[1.0]IL1B[1.0]IL18 3

IL1R2 9.006 448 0.037 0.530 0.447 2 TLR3[1.002]MYD88[1.0]IL1B[1.0]IL1R2 3

IL1RN 9.006 449 0.037 0.530 0.447 2 TLR3[1.002]MYD88[1.0]IL1R1[1.0]IL1RN 3

IL1RAP 9.009 450 0.037 0.530 0.447 2 TLR3[1.002]MYD88[1.0]IL1B[1.001]IL1RAP 3

IL8 9.009 451 0.038 0.530 0.447 2 TLR3[1.002]MYD88[1.0]IL1B[1.001]IL8 3

IL1A 9.012 452 0.038 0.530 0.447 2 TLR3[1.002]MYD88[1.0]IRAK1[1.002]IL1A 3

TOLLIP 9.012 453 0.038 0.530 0.447 2 TLR3[1.002]MYD88[1.0]IRAK1[1.002]TOLLIP 3

CASP10 9.012 454 0.038 0.530 0.447 2 TLR3[1.002]MYD88[1.002]FADD[1.0]CASP10 3

CASP8 9.012 455 0.038 0.530 0.447 2 TLR3[1.002]MYD88[1.002]FADD[1.0]CASP8 3

CFLAR 9.012 456 0.038 0.530 0.447 2 TLR3[1.002]MYD88[1.002]FADD[1.0]CFLAR 3

FAS 9.012 457 0.038 0.530 0.447 2 TLR3[1.002]MYD88[1.002]FADD[1.0]FAS 3

FASLG 9.012 458 0.038 0.530 0.447 2 TLR3[1.002]MYD88[1.002]FADD[1.0]FASLG 3

TNFRSF10A 9.012 459 0.038 0.530 0.447 2 TLR3[1.002]MYD88[1.002]FADD[1.0]TNFRSF10A 3

TNFRSF10B 9.012 460 0.038 0.530 0.447 2 TLR3[1.002]MYD88[1.002]FADD[1.0]TNFRSF10B 3

TRADD 9.012 461 0.038 0.530 0.447 2 TLR3[1.002]MYD88[1.002]FADD[1.0]TRADD 3

TANK 9.015 462 0.038 0.530 0.448 2 TLR3[1.001]TRIF[1.001]IRF3[1.003]TANK 3

NEMO (IKBKG) 9.018 463 0.039 0.530 0.448 2 TLR3[1.002]MYD88[1.0]IRAK1[1.004]NEMO 3

MAP3K7IP2 9.018 464 0.039 0.530 0.448 2 TLR3[1.002]MYD88[1.0]IRAK1[1.004]MAP3K7IP2 3

AKAP2 9.020 465 0.039 0.531 0.448 2 TLR3[1.405]SRC[3.105]AKAP2 2

MKI67 9.020 466 0.039 0.531 0.448 2 TLR3[1.405]SRC[3.105]MKI67 2

BCL10 9.024 467 0.039 0.531 0.448 2 TLR3[1.002]MYD88[1.0]TLR4[1.006]BCL10 3

IFNB1 9.024 468 0.039 0.531 0.448 2 TLR3[1.001]TRIF[1.001]IRF3[1.006]IFNB1 3

LBP 9.024 469 0.039 0.531 0.448 2 TLR3[1.002]MYD88[1.006]CD14[1.0]LBP 3

TMEM173 9.024 470 0.039 0.531 0.448 2 TLR3[1.001]TRIF[1.004]TBK1[1.003]TMEM173 3

IFNA1 9.030 471 0.039 0.531 0.448 2 TLR3[1.002]MYD88[1.0]IRF7[1.008]IFNA1 3

IFNA2 9.030 472 0.039 0.531 0.448 2 TLR3[1.002]MYD88[1.0]IRF7[1.008]IFNA2 3

CCL5 9.033 473 0.039 0.531 0.448 2 TLR3[1.001]TRIF[1.001]IRF3[1.009]CCL5 3

IKBKB 9.039 474 0.039 0.532 0.449 2 TLR3[1.002]MYD88[1.0]IRAK1[1.011]IKBKB 3

CD40 9.042 475 0.040 0.532 0.449 2 TLR3[1.001]TRIF[1.013]TRAF6[1.0]CD40 3

IKBKA (CHUK) 9.042 476 0.040 0.532 0.449 2 TLR3[1.002]MYD88[1.0]IRAK1[1.012]IKBKA 3

MAP3K7 9.042 477 0.040 0.532 0.449 2 TLR3[1.001]TRIF[1.013]TRAF6[1.0]MAP3K7 3

MAP3K7IP1 9.042 478 0.040 0.532 0.449 2 TLR3[1.001]TRIF[1.013]TRAF6[1.0]MAP3K7IP1 3

TNFRSF11A 9.042 479 0.040 0.532 0.449 2 TLR3[1.001]TRIF[1.013]TRAF6[1.0]TNFRSF11A 3

UBE2N 9.042 480 0.040 0.532 0.449 2 TLR3[1.001]TRIF[1.013]TRAF6[1.0]UBE2N 3

DDX58 9.045 481 0.040 0.532 0.449 2 TLR3[1.001]TRIF[1.001]IRF3[1.013]DDX58 3


SQSTM1 9.048 483 0.040 0.532 0.449 2 TLR3[1.001]TRIF[1.013]TRAF6[1.002]SQSTM1 3

TBKBP1 (SINTBAD) 9.048 484 0.040 0.532 0.449 2 TLR3[1.001]TRIF[1.004]TBK1[1.011]TBKBP1 3

HSP90B1 9.051 485 0.040 0.532 0.449 2 TLR3[1.002]MYD88[1.0]TLR4[1.015]HSP90B1 3

MALT1 9.051 486 0.040 0.532 0.449 2 TLR3[1.001]TRIF[1.013]TRAF6[1.003]MALT1 3

MAP3K7IP3 9.054 487 0.041 0.533 0.450 2 TLR3[1.001]TRIF[1.013]TRAF6[1.004]MAP3K7IP3 3

TAX1BP1 9.054 488 0.041 0.533 0.450 2 TLR3[1.001]TRIF[1.013]TRAF6[1.004]TAX1BP1 3

IL33 9.057 489 0.041 0.533 0.450 2 TLR3[1.002]MYD88[1.0]IL1R1[1.017]IL33 3

IRAK1BP1 9.057 490 0.041 0.533 0.450 2 TLR3[1.002]MYD88[1.0]IRAK1[1.017]IRAK1BP1 3

NGFR 9.057 491 0.041 0.533 0.450 2 TLR3[1.001]TRIF[1.013]TRAF6[1.005]NGFR 3

CLEC7A 9.057 492 0.041 0.533 0.450 2 TLR3[1.002]MYD88[1.004]TLR2[1.013]CLEC7A 3

SPG7 9.063 493 0.041 0.533 0.450 2 TLR3[1.002]MYD88[1.004]TLR2[1.015]SPG7 3

CYLD 9.075 494 0.041 0.534 0.451 2 TLR3[1.001]TRIF[1.013]TRAF6[1.011]CYLD 3

MAVS 9.075 495 0.041 0.534 0.451 2 TLR3[1.001]TRIF[1.013]TRAF6[1.011]MAVS 3

IL1RL2 9.078 496 0.041 0.534 0.451 2 TLR3[1.002]MYD88[1.0]IL1B[1.024]IL1RL2 3

BTK 9.081 497 0.041 0.534 0.451 2 TLR3[1.002]MYD88[1.0]TLR4[1.025]BTK 3

RIPK2 9.081 498 0.041 0.534 0.451 2 TLR3[1.001]TRIF[1.013]TRAF6[1.013]RIPK2 3

TRAF2 9.084 499 0.042 0.534 0.451 2 TLR3[1.001]TRIF[1.004]TBK1[1.023]TRAF2 3

EDA2R 9.087 500 0.042 0.535 0.451 2 TLR3[1.001]TRIF[1.013]TRAF6[1.015]EDA2R 3

JUN 9.090 501 0.042 0.535 0.451 2 TLR3[1.001]TRIF[1.001]IRF3[1.028]JUN 3

ATF2 9.090 502 0.042 0.535 0.451 2 TLR3[1.001]TRIF[1.001]IRF3[1.028]ATF2 3

BIRC2 9.096 503 0.042 0.535 0.452 2 TLR3[1.001]TRIF[1.031]RIP1[1.0]BIRC2 3

SHROOM2 9.098 504 0.042 0.535 0.452 2 TLR3[1.405]SRC[3.144]SHROOM2 2

ECSIT 9.099 505 0.042 0.535 0.452 2 TLR3[1.001]TRIF[1.013]TRAF6[1.019]ECSIT 3

BID 9.099 506 0.042 0.535 0.452 2 TLR3[1.002]MYD88[1.002]FADD[1.029]BID 3

BIRC3 9.102 507 0.042 0.535 0.452 2 TLR3[1.001]TRIF[1.031]RIP1[1.002]BIRC3 3

TIFA 9.102 508 0.042 0.535 0.452 2 TLR3[1.001]TRIF[1.013]TRAF6[1.02]TIFA 3

CRADD 9.105 509 0.042 0.536 0.452 2 TLR3[1.001]TRIF[1.031]RIP1[1.003]CRADD 3

EP300 9.108 510 0.042 0.536 0.452 2 TLR3[1.002]MYD88[1.029]IRF1[1.005]EP300 3

TLR1 9.111 511 0.043 0.536 0.452 2 TLR3[1.002]MYD88[1.004]TLR2[1.031]TLR1 3

ZBP1 9.111 512 0.043 0.536 0.452 2 TLR3[1.001]TRIF[1.001]IRF3[1.035]ZBP1 3


STAT2 9.114 514 0.043 0.536 0.453 2 TLR3[1.002]MYD88[1.0]IRF7[1.036]STAT2 3

KRR1 9.117 515 0.043 0.536 0.453 2 TLR3[1.002]MYD88[1.002]FADD[1.035]KRR1 3

SIGIRR 9.117 516 0.043 0.536 0.453 2 TLR3[1.002]MYD88[1.0]IL1B[1.037]SIGIRR 3

TLR6 9.123 517 0.043 0.537 0.453 2 TLR3[1.002]MYD88[1.004]TLR2[1.035]TLR6 3

BAD 9.126 518 0.043 0.537 0.453 2 TLR3[1.002]MYD88[1.04]AKT1[1.0]BAD 3

FOXO3 9.126 519 0.043 0.537 0.453 2 TLR3[1.002]MYD88[1.04]AKT1[1.0]FOXO3 3

MDM2 9.126 520 0.043 0.537 0.453 2 TLR3[1.002]MYD88[1.04]AKT1[1.0]MDM2 3

MTOR 9.126 521 0.043 0.537 0.453 2 TLR3[1.002]MYD88[1.04]AKT1[1.0]MTOR 3

NOS3 9.126 522 0.043 0.537 0.453 2 TLR3[1.002]MYD88[1.04]AKT1[1.0]NOS3 3

TERT 9.126 523 0.044 0.537 0.453 2 TLR3[1.002]MYD88[1.04]AKT1[1.0]TERT 3

TSC1 9.126 524 0.044 0.537 0.453 2 TLR3[1.002]MYD88[1.04]AKT1[1.0]TSC1 3

TSC2 9.126 525 0.044 0.537 0.453 2 TLR3[1.002]MYD88[1.04]AKT1[1.0]TSC2 3

CREB1 9.129 526 0.044 0.537 0.453 2 TLR3[1.002]MYD88[1.04]AKT1[1.001]CREB1 3

EIF4EBP1 9.129 527 0.044 0.537 0.453 2 TLR3[1.002]MYD88[1.04]AKT1[1.001]EIF4EBP1 3

GRB10 9.129 528 0.044 0.537 0.453 2 TLR3[1.002]MYD88[1.04]AKT1[1.001]GRB10 3

ILK 9.129 529 0.044 0.537 0.453 2 TLR3[1.002]MYD88[1.04]AKT1[1.001]ILK 3

PHLPP1 9.129 530 0.044 0.537 0.453 2 TLR3[1.002]MYD88[1.04]AKT1[1.001]PHLPP1 3

RICTOR 9.129 531 0.044 0.537 0.453 2 TLR3[1.002]MYD88[1.04]AKT1[1.001]RICTOR 3

APPL1 9.132 532 0.044 0.537 0.453 2 TLR3[1.002]MYD88[1.04]AKT1[1.002]APPL1 3

GSK3B 9.132 533 0.044 0.537 0.453 2 TLR3[1.002]MYD88[1.04]AKT1[1.002]GSK3B 3

LOC119358 9.132 534 0.044 0.537 0.453 2 TLR3[1.002]MYD88[1.0]TLR4[1.042]LOC119358 3

NR4A1 9.132 535 0.045 0.537 0.453 2 TLR3[1.002]MYD88[1.04]AKT1[1.002]NR4A1 3

1445 9.132 536 0.045 0.537 0.453 2 TLR3[1.002]MYD88[1.006]CD14[1.036]1445 3

PSEN1 9.135 537 0.045 0.537 0.454 2 TLR3[1.001]TRIF[1.013]TRAF6[1.031]PSEN1 3

SLC2A4 9.135 538 0.045 0.537 0.454 2 TLR3[1.002]MYD88[1.04]AKT1[1.003]SLC2A4 3

TCL1A 9.135 539 0.045 0.537 0.454 2 TLR3[1.002]MYD88[1.04]AKT1[1.003]TCL1A 3

ACAP1 9.138 540 0.045 0.538 0.454 2 TLR3[1.405]SRC[3.164]ACAP1 2

LOC100287510 9.138 541 0.045 0.538 0.454 2 TLR3[1.002]MYD88[1.04]AKT1[1.004]LOC100287510 3

PEA15 9.141 542 0.045 0.538 0.454 2 TLR3[1.002]MYD88[1.002]FADD[1.043]PEA15 3

EZR 9.144 543 0.045 0.538 0.454 2 TLR3[1.002]MYD88[1.002]FADD[1.044]EZR 3

HSPA4 9.147 544 0.045 0.538 0.454 2 TLR3[1.002]MYD88[1.0]TLR4[1.047]HSPA4 3

PTK6 9.150 545 0.045 0.538 0.454 2 TLR3[1.002]MYD88[1.041]STAP2[1.007]PTK6 3

SH2D3A 9.150 546 0.045 0.538 0.454 2 TLR3[1.001]TRIF[1.001]IRF3[1.048]SH2D3A 3

THEM4 9.150 547 0.046 0.538 0.454 2 TLR3[1.002]MYD88[1.04]AKT1[1.008]THEM4 3

PDLIM7 9.153 548 0.046 0.538 0.454 2 TLR3[1.002]MYD88[1.0]IRF7[1.049]PDLIM7 3

LRDD 9.153 549 0.046 0.538 0.454 2 TLR3[1.001]TRIF[1.031]RIP1[1.019]LRDD 3

DEDD 9.156 550 0.046 0.539 0.455 2 TLR3[1.002]MYD88[1.002]FADD[1.048]DEDD 3

FSTL1 9.159 551 0.046 0.539 0.455 2 TLR3[1.002]MYD88[1.004]TLR2[1.047]FSTL1 3

OPTN 9.162 552 0.046 0.539 0.455 2 TLR3[1.001]TRIF[1.004]TBK1[1.049]OPTN 3

ARFIP2 9.162 553 0.046 0.539 0.455 2 TLR3[1.002]MYD88[1.052]RAC1[1.0]ARFIP2 3

ELMO1 9.162 554 0.046 0.539 0.455 2 TLR3[1.002]MYD88[1.052]RAC1[1.0]ELMO1 3

IQGAP1 9.162 555 0.046 0.539 0.455 2 TLR3[1.002]MYD88[1.052]RAC1[1.0]IQGAP1 3

NCF2 9.162 556 0.046 0.539 0.455 2 TLR3[1.002]MYD88[1.052]RAC1[1.0]NCF2 3

NCKAP1 9.162 557 0.046 0.539 0.455 2 TLR3[1.002]MYD88[1.052]RAC1[1.0]NCKAP1 3

PAK1 9.162 558 0.046 0.539 0.455 2 TLR3[1.002]MYD88[1.052]RAC1[1.0]PAK1 3

BAIAP2 9.165 559 0.047 0.539 0.455 2 TLR3[1.002]MYD88[1.052]RAC1[1.001]BAIAP2 3

KALRN 9.165 560 0.047 0.539 0.455 2 TLR3[1.002]MYD88[1.052]RAC1[1.001]KALRN 3

RAP1GDS1 9.165 561 0.047 0.539 0.455 2 TLR3[1.002]MYD88[1.052]RAC1[1.001]RAP1GDS1 3

TRIO 9.165 562 0.047 0.539 0.455 2 TLR3[1.002]MYD88[1.052]RAC1[1.001]TRIO 3

WASF2 9.165 563 0.047 0.539 0.455 2 TLR3[1.002]MYD88[1.052]RAC1[1.001]WASF2 3

FHOD1 9.168 564 0.047 0.539 0.455 2 TLR3[1.002]MYD88[1.052]RAC1[1.002]FHOD1 3

FOXA2 9.168 565 0.047 0.539 0.455 2 TLR3[1.002]MYD88[1.04]AKT1[1.014]FOXA2 3

MAP3K11 9.168 566 0.047 0.539 0.455 2 TLR3[1.002]MYD88[1.052]RAC1[1.002]MAP3K11 3

TIAM1 9.168 567 0.047 0.539 0.455 2 TLR3[1.002]MYD88[1.052]RAC1[1.002]TIAM1 3

S1PR1 9.171 568 0.047 0.539 0.455 2 TLR3[1.002]MYD88[1.04]AKT1[1.015]S1PR1 3

ARHGEF4 9.171 569 0.047 0.539 0.455 2 TLR3[1.002]MYD88[1.052]RAC1[1.003]ARHGEF4 3

PARD6A 9.171 570 0.047 0.539 0.455 2 TLR3[1.002]MYD88[1.052]RAC1[1.003]PARD6A 3

RACGAP1 9.171 571 0.048 0.539 0.455 2 TLR3[1.002]MYD88[1.052]RAC1[1.003]RACGAP1 3

WASF1 9.171 572 0.048 0.539 0.455 2 TLR3[1.002]MYD88[1.052]RAC1[1.003]WASF1 3

NRIP1 9.174 573 0.048 0.540 0.455 2 TLR3[1.002]MYD88[1.04]AKT1[1.016]NRIP1 3

RPS6KB1 9.174 574 0.048 0.540 0.455 2 TLR3[1.002]MYD88[1.04]AKT1[1.016]RPS6KB1 3


CYBA 9.177 576 0.048 0.540 0.456 2 TLR3[1.002]MYD88[1.052]RAC1[1.005]CYBA 3

GIT1 9.177 577 0.048 0.540 0.456 2 TLR3[1.002]MYD88[1.052]RAC1[1.005]GIT1 3

PLXNB1 9.177 578 0.048 0.540 0.456 2 TLR3[1.002]MYD88[1.052]RAC1[1.005]PLXNB1 3

NOX4 9.180 579 0.048 0.540 0.456 2 TLR3[1.002]MYD88[1.0]TLR4[1.058]NOX4 3

ARHGAP5 9.183 580 0.048 0.540 0.456 2 TLR3[1.002]MYD88[1.052]RAC1[1.007]ARHGAP5 3

HSPB1 9.183 581 0.048 0.540 0.456 2 TLR3[1.002]MYD88[1.04]AKT1[1.019]HSPB1 3

MTCP1 9.183 582 0.048 0.540 0.456 2 TLR3[1.002]MYD88[1.04]AKT1[1.019]MTCP1 3

NOXA1 9.183 583 0.049 0.540 0.456 2 TLR3[1.002]MYD88[1.052]RAC1[1.007]NOXA1 3

RYBP 9.183 584 0.049 0.540 0.456 2 TLR3[1.002]MYD88[1.002]FADD[1.057]RYBP 3

VAV3 9.183 585 0.049 0.540 0.456 2 TLR3[1.002]MYD88[1.052]RAC1[1.007]VAV3 3

DOCK2 9.186 586 0.049 0.540 0.456 2 TLR3[1.002]MYD88[1.052]RAC1[1.008]DOCK2 3

GEFT 9.189 587 0.049 0.541 0.456 2 TLR3[1.002]MYD88[1.052]RAC1[1.009]GEFT 3

MAPK8 9.189 588 0.049 0.541 0.456 2 TLR3[1.002]MYD88[1.002]FADD[1.059]MAPK8 3

NF2 9.189 589 0.049 0.541 0.456 2 TLR3[1.002]MYD88[1.04]AKT1[1.021]NF2 3

IQGAP2 9.192 590 0.049 0.541 0.456 2 TLR3[1.002]MYD88[1.052]RAC1[1.01]IQGAP2 3

NOX1 9.192 591 0.049 0.541 0.456 2 TLR3[1.002]MYD88[1.052]RAC1[1.01]NOX1 3

NGEF 9.195 592 0.049 0.541 0.457 2 TLR3[1.002]MYD88[1.052]RAC1[1.011]NGEF 3

MAPKAP1 9.198 593 0.049 0.541 0.457 2 TLR3[1.002]MYD88[1.04]AKT1[1.024]MAPKAP1 3

PAX7 9.198 594 0.049 0.541 0.457 2 TLR3[1.405]SRC[3.194]PAX7 2

RALBP1 9.198 595 0.050 0.541 0.457 2 TLR3[1.002]MYD88[1.052]RAC1[1.012]RALBP1 3

USP8 9.201 596 0.050 0.541 0.457 2 TLR3[1.002]MYD88[1.04]AKT1[1.025]USP8 3

STAT5A 9.201 597 0.050 0.541 0.457 2 TLR3[1.002]MYD88[1.041]STAP2[1.024]STAT5A 3


LOC440577 9.207 599 0.050 0.542 0.457 2 TLR3[1.002]MYD88[1.04]AKT1[1.027]LOC440577 3

NCF1 9.207 600 0.050 0.542 0.457 2 TLR3[1.002]MYD88[1.052]RAC1[1.015]NCF1 3

Each target gene is ranked according to its estimated biological distance from TLR3 among the 12,009 genes in the TLR3 connectome. The sphere of each human

gene surrounding TLR3 is determined as follows: 0 for genes in the top 0.1% in terms of their proximity to TLR3, 1 for the top 1%, 2 for the top 5%, 3 for the top

10%, 4 for the top 25%, 5 for the top 50%, 6 for the top 75% and 7 for the lowest 25%. The P-value specifying the significance of the proximity of a gene to

TLR3 was determined by calculating the probability of a random gene being closer to TLR3 in the connectome. The ratio of the distance between a given gene

and TLR3 to the mean and median values of all TLR3 connectome genes was calculated. The numbers in square brackets in the route description specify the

direct biological distance between the two genes (Eq. 1). The degree of separation from TLR3 is the number of connections on the route predicted between the

gene and TLR3, and the weighted distance was calculated by summing the direct biological distances and multiplying by the degrees of separation (Eq. 2).

· web viewtable s1. top 5% of the genes of the tlr3 connectome

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