… rejection transplantation biology:. kidney rejection:
TRANSCRIPT
… Rejection
Transplantation Biology:
Kidney rejection:
Allograft rejection: specificity and memmory.
Adoptive transfer of skin allograft rejection.
MHC-matching: microcytotoxicity assay
Microcytotoxicity test.
Mixed Lymphocyte Reaction.
Luminex Cross-matching Assay:Checks for the presence of pre-existing anti-HLA antibodies in recipient serum to assess the risk of hyperacute rejection.
Organ Rejection:
1. Hyperacute (immediate) : hoursPre-existing antibodies.
2. Acute: (weeks)Cell-mediated – MHC-mismatch.
3. Chronic (months, years)minor histocompatibility antigens.
Transplantation of blood: blood transfusion.
Hyperacute rejection of kidney graft.
Allo-antibodies and chronic rejection.
Black: Azathioprine + corticosteroids
Blue: Cyclosporin A + corticosteroids
Fraternal twins cattle
“Transfusion of a goat’s blood” (1892) Jules Andler (1865-1952).
