β-blockers and ocular hypertension

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clinical pharmacology \.. AND OCULAR HYPERTENSION ... Oral Doses of Atenolol Compared with Propranolol In 10 patients attending glaucoma clinics a single oral dose (5 Omg) of atenolol was significantly more effective than propranolol 40mg in reducing oCular tension. For both treatments a significant reduction in mean tensions occurred 2 hours after. administration and was maintained after 7 hOUTS. At all times the mean fall in ocular tension was greater with atenolol. There was no reduction in diastolic BP after either drug but falls in systolic pressure were observed at 2, 4, 5 and 6 hours afte; and 3 hours after atenolol. Pulse rate was reduced 2 hours after administration of both drugs. 'It will be interesting to observe the effect of atenolol rye drops when they become available . .. if the expected fall in pressure is confirmed, a drug suitablefor local administration may become available in clinical management of glaucoma. ' MacDonald. MJ. et aI.: British Journal of Ophthalmology 60: 789 (Nov 1976) ... Decrease .in Press.ure with Propranolol is Dose-Related In a single-blind trial, a dose.-dependent decreas.e of intraocular pressure was observed in 6 ocular hypertensive patients given oral propranolol ('Inderal') in doses of 20, .40 and 80mg 48 hours apart. The decrease in intraocular pressure was maximal at 3 hours after adqlinistration of propranolol at all dose levels and was still evident at 6 hours. The absolute reduction was greater in' the group with the highest initial intraocular pressure. There was a simultaneous decrease in pulse rate which was also dose-related and reached its maximum 2 hours after administration. A moderate decrease in systolic and diastolic BP was noted, but only attained statistical significance with one patient and d.id not appear to be dose-related: The virtual absence of a significant decrease in systemic blood pressure and lack of a dose-related effect suggests that the fall in blood pressure is not the primary cause of the reduced intraocular pressure. Wettrell. K. and Pandolfi. M.: British Journal of Ophthalmology 60: 680 (Oct 1976) INPHARMA 5th February, 1977 p13

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Page 1: β-BLOCKERS AND OCULAR HYPERTENSION

clinical pharmacology \..

~-BLOCKERS AND OCULAR HYPERTENSION

... Oral Doses of Atenolol Compared with Propranolol In 10 patients attending glaucoma clinics a single oral dose (5 Omg) of atenolol was significantly more effective than propranolol 40mg in reducing oCular tension. For both treatments a significant reduction in mean tensions occurred 2 hours after. administration and was maintained after 7 hOUTS. At all times the mean fall in ocular tension was greater with atenolol. There was no reduction in diastolic BP after either drug but falls in systolic pressure were observed at 2, 4, 5 and 6 hours afte; propr~olol and 3 hours after atenolol. Pulse rate was reduced 2 hours after administration of both drugs.

'It will be interesting to observe the effect of atenolol rye drops when they become available . .. if the expected fall in pressure is confirmed, a ~-blocking drug suitablefor local administration may become available in clinical management of glaucoma. '

MacDonald. MJ. et aI.: British Journal of Ophthalmology 60: 789 (Nov 1976)

... Decrease .in Press.ure with Propranolol is Dose-Related In a single-blind trial, a dose.-dependent decreas.e of intraocular pressure was observed in 6 ocular hypertensive patients given oral propranolol ('Inderal') in doses of 20, .40 and 80mg 48 hours apart. The decrease in intraocular pressure was maximal at 3 hours after adqlinistration of propranolol at all dose levels and was still evident at 6 hours. The absolute reduction was greater in' the group with the highest initial intraocular pressure. There was a simultaneous decrease in pulse rate which was also dose-related and reached its maximum 2 hours after administration. A moderate decrease in systolic and diastolic BP was noted, but only attained statistical significance with one patient and d.id not appear to be dose-related: The virtual absence of a significant decrease in systemic blood pressure and lack of a dose-related effect suggests that the fall in blood pressure is not the primary cause of the reduced intraocular pressure.

Wettrell. K. and Pandolfi. M.: British Journal of Ophthalmology 60: 680 (Oct 1976)

INPHARMA 5th February, 1977 p13